Saa3

Summary

Gene Symbol: Saa3
Description: serum amyloid A 3
Alias: AV098916, Saa-3, l7R3, serum amyloid A-3 protein
Species: mouse

Top Publications

  1. ncbi Regulation of mouse serum amyloid A3 gene expression during acute phase reaction
    H Shimizu
    Department of Molecular Pathology, Kanazawa University, Japan
    Folia Histochem Cytobiol 30:141-2. 1992
  2. ncbi Structure of the murine serum amyloid A gene family. Gene conversion
    C A Lowell
    J Biol Chem 261:8442-52. 1986
  3. doi The adipokine SAA3 is induced by interleukin-1beta in mouse adipocytes
    Grit Sommer
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    J Cell Biochem 104:2241-7. 2008
  4. pmc Acute-phase serum amyloid A as a marker of insulin resistance in mice
    Ludger Scheja
    Department of Biochemistry and Molecular Biology II, University Medical Center, 20246 Hamburg, Germany
    Exp Diabetes Res 2008:230837. 2008
  5. ncbi Tumor necrosis factor-alpha induces serum amyloid A3 in mouse granulosa cells
    Deok Soo Son
    Center for Reproductive Sciences and Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Endocrinology 145:2245-52. 2004
  6. doi The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
    Sachie Hiratsuka
    Department of Pharmacology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Nat Cell Biol 10:1349-55. 2008
  7. ncbi NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines
    H Shimizu
    Department of Molecular Pathology, Kanazawa University, Ishikawa, Japan
    Gene 149:305-10. 1994
  8. pmc Serum amyloid A3 does not contribute to circulating SAA levels
    Tsuyoshi Chiba
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Lipid Res 50:1353-62. 2009
  9. pmc Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota
    Christopher S Reigstad
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 4:e5842. 2009
  10. pmc Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice
    Jennifer L Ather
    Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 187:64-73. 2011

Research Grants

Scientific Experts

  • Jin Liu
  • E M Rinchik
  • Cymbeline T Culiat
  • Deok Soo Son
  • Alan Chait
  • Tsuyoshi Chiba
  • Chang Yeop Han
  • Shilpa Choudhary
  • Roman Thaler
  • Laura J den Hartigh
  • Jung Mi Lee
  • MEHABAW G DEREBE
  • Hiroaki Shigemura
  • David I Kasahara
  • Atsuko Deguchi
  • Edson Mendes de Oliveira
  • Melina Villalba
  • Shari Wang
  • Kevin D O'Brien
  • Jennifer L Ather
  • Savitha Subramanian
  • Kensuke Miyake
  • Sachiko Akashi-Takamura
  • Yoshiro Maru
  • Christopher S Reigstad
  • Heon Park
  • Sachie Hiratsuka
  • Grit Sommer
  • Ludger Scheja
  • Paul F Terranova
  • Katherine F Roby
  • A Kurata
  • Joseph A Baur
  • JINING LU
  • Qing Zhang
  • Joseph Lorenzo
  • Christian E Jacome-Galarza
  • Carol Pilbeam
  • Thomas Estus
  • Hector L Aguila
  • Alexandra Goetjen
  • Klaus Klaushofer
  • Scott M Riester
  • Monika Rumpler
  • Silvia Spitzer
  • Jochen Zwerina
  • Franz Varga
  • Andre J Van Wijnen
  • Ines Sturmlechner
  • Yilei Ding
  • Michelle Averill
  • Yeon Jeong Kim
  • Shipra Vaishnava
  • Noelle S Williams
  • InSu Jeon
  • Hyun Jeong Ko
  • Boyeong Song
  • Leela Goodspeed
  • Chang Yuil Kang
  • Sureka Gattu
  • Hyungseok Seo
  • John B Macmillan
  • Naotaka Ishiguro
  • Lora V Hooper
  • Kelly A Ruhn
  • Yasuo Inoshima
  • Min Ji Chae
  • Clare M Zlatkov
  • Eun Kyung Kim
  • Tomasz Wietecha
  • Gretchen E Diehl
  • Young Jun Park
  • Yun Sun Kim
  • Caroline Garcia Iglesias Contesini
  • Franciele Hinterholz Knebel
  • Satoshi Takahashi
  • Leandro A Benedito
  • Akiko Komatsu
  • Stephanie A Shore
  • Ana Campa
  • Christopher Hug
  • Natsuko Tanimura
  • Alison S Williams
  • Umeharu Ohto
  • Lester Kobzik
  • Takeshi Tomita
  • Tsutomu Omori
  • Silvana Sandri
  • Fabíola Branco Filippin-Monteiro
  • Barbara Ranscht

Detail Information

Publications46

  1. ncbi Regulation of mouse serum amyloid A3 gene expression during acute phase reaction
    H Shimizu
    Department of Molecular Pathology, Kanazawa University, Japan
    Folia Histochem Cytobiol 30:141-2. 1992
  2. ncbi Structure of the murine serum amyloid A gene family. Gene conversion
    C A Lowell
    J Biol Chem 261:8442-52. 1986
    ..Comparison of the upstream regions of the SAA genes with those of the rat fibrinogen genes, whose expression is also induced by inflammation, reveals sequences common to all six genes which are very improbable on a random basis...
  3. doi The adipokine SAA3 is induced by interleukin-1beta in mouse adipocytes
    Grit Sommer
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    J Cell Biochem 104:2241-7. 2008
    ..In the current study, regulation of SAA3 by the proinflammatory and insulin resistance-inducing cytokine interleukin (IL)-1beta was determined in 3T3-L1 and ..
  4. pmc Acute-phase serum amyloid A as a marker of insulin resistance in mice
    Ludger Scheja
    Department of Biochemistry and Molecular Biology II, University Medical Center, 20246 Hamburg, Germany
    Exp Diabetes Res 2008:230837. 2008
    ..In adipose tissue Saa3 was the predominant isoform and the earliest inflammatory marker induced, suggesting it is important for initiation ..
  5. ncbi Tumor necrosis factor-alpha induces serum amyloid A3 in mouse granulosa cells
    Deok Soo Son
    Center for Reproductive Sciences and Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Endocrinology 145:2245-52. 2004
    ..Serum amyloid A3 (SAA3), a main acute-phase protein, was induced by TNF in granulosa cells...
  6. doi The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase
    Sachie Hiratsuka
    Department of Pharmacology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Nat Cell Biol 10:1349-55. 2008
    ..show that in lung endothelial cells and macrophages, Toll-like receptor (TLR) 4 acts as a functional receptor for SAA3 in the pre-metastatic phase...
  7. ncbi NF-kappa B and C/EBP transcription factor families synergistically function in mouse serum amyloid A gene expression induced by inflammatory cytokines
    H Shimizu
    Department of Molecular Pathology, Kanazawa University, Ishikawa, Japan
    Gene 149:305-10. 1994
    ..We demonstrate that the expression of one of SAA genes (SAA3) is induced by interleukin-1 (IL-1), and that other inflammatory cytokines such as IL-6 and leukemia inhibitory ..
  8. pmc Serum amyloid A3 does not contribute to circulating SAA levels
    Tsuyoshi Chiba
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Lipid Res 50:1353-62. 2009
    ..We took advantage of the difference in the inducible isoforms of SAA secreted by adipose tissue (SAA3) and liver (SAA1 and 2) of mice to evaluate whether adipose tissue contributes to the circulating pool of SAA in ..
  9. pmc Regulation of serum amyloid A3 (SAA3) in mouse colonic epithelium and adipose tissue by the intestinal microbiota
    Christopher S Reigstad
    Sahlgrenska Center for Cardiovascular and Metabolic Research Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden
    PLoS ONE 4:e5842. 2009
    ..Adipose tissue-derived SAA3 displays monocyte chemotactic activity and may play a role in metabolic inflammation associated with obesity and ..
  10. pmc Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice
    Jennifer L Ather
    Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 187:64-73. 2011
    ..In this study, we demonstrate that Saa3 is expressed in the lungs of mice exposed to several mixed Th2/Th17-polarizing allergic sensitization regimens...
  11. ncbi Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion
    Chang Yeop Han
    Department of Medicine, University of Washington, Seattle, Washington 98195 6426, USA
    Diabetes 56:2260-73. 2007
    ..receptor (PPAR)gamma was downregulated in hypertrophic 3T3-L1 cells, with increased expression of SAA3 and increased hyaluronan production. Rosiglitazone, a PPARgamma agonist, reversed these changes...
  12. doi Herpes simplex virus type 1 induces simultaneous activation of Toll-like receptors 2 and 4 and expression of the endogenous ligand serum amyloid A in astrocytes
    Melina Villalba
    Instituto de Microbiologia Clinica, Facultad de Medicina, Universidad Austral de Chile, P O Box 567, Valdivia, Chile
    Med Microbiol Immunol 201:371-9. 2012
    ..of interferon regulatory factors IRF3 and IRF7, interferon β (INFβ), interleukin 6 (IL6), and serum amyloid A (SAA3) transcripts, as well as phospho-IRF3 protein...
  13. pmc Resveratrol improves health and survival of mice on a high-calorie diet
    Joseph A Baur
    Department of Pathology, Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 444:337-42. 2006
    ..These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing...
  14. ncbi Blockade of Angiotensin II type-1 receptor reduces oxidative stress in adipose tissue and ameliorates adipocytokine dysregulation
    A Kurata
    Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan
    Kidney Int 70:1717-24. 2006
    ..Ang II signaling and subsequent oxidative stress in adipose tissue may be potential targets for the prevention of atherosclerotic cardiovascular disease in metabolic syndrome and also in metabolic syndrome-based CKD...
  15. pmc Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: a fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
    Eugene M Rinchik
    Life Sciences Division, Oak Ridge National Laboratory, P O Box 2009, Oak Ridge, TN 37831 8077, USA
    Proc Natl Acad Sci U S A 99:844-9. 2002
    ..Four complementation groups were defined by seven prenatally lethal mutations, including a group (l7R3) comprised of two alleles of obvious differing severity...
  16. pmc A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity
    Heon Park
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    J Exp Med 205:2899-913. 2008
    ....
  17. doi Hypoxia increases serum amyloid A3 (SAA3) in differentiated 3T3-L1 adipocytes
    Edson Mendes de Oliveira
    Department of Clinical and Toxicological Analysis, Faculty of Pharmaceutical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 580, Sao Paulo, CEP 05508 900, Brazil
    Inflammation 36:1107-10. 2013
    ..Hypoxia leads to a substantial increase in SAA3 mRNA and protein level, apparently in a time-dependent manner (threefold in 48 h), in fully differentiated 3T3-L1, ..
  18. pmc Role of the adiponectin binding protein, T-cadherin (cdh13), in pulmonary responses to subacute ozone
    David I Kasahara
    Department of Environmental Health, Harvard School of Public Health HSPH, Boston, Massachusetts, United States of America
    PLoS ONE 8:e65829. 2013
    ..Similar results were obtained for pulmonary mRNA expression of saa3, an acute phase protein capable of inducing IL-17A expression...
  19. doi Serum amyloid A3 binds MD-2 to activate p38 and NF-κB pathways in a MyD88-dependent manner
    Atsuko Deguchi
    Department of Pharmacology, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    J Immunol 191:1856-64. 2013
    Serum amyloid A (SAA) 3 is a major component of the acute phase of inflammation. We previously reported that SAA3 served as an endogenous peptide ligand for TLR4 to facilitate lung metastasis...
  20. doi Serum amyloid A3 exacerbates cancer by enhancing the suppressive capacity of myeloid-derived suppressor cells via TLR2-dependent STAT3 activation
    Jung Mi Lee
    Laboratory of Immunology, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Korea
    Eur J Immunol 44:1672-84. 2014
    ..In this study, we proposed a novel mechanism by which serum amyloid A3 (SAA3), a well-known inflammatory factor, connects MDSCs with cancer progression...
  21. pmc Up-regulation of MUC2 mucin expression by serum amyloid A3 protein in mouse colonic epithelial cells
    Hiroaki Shigemura
    Laboratory of Food and Environmental Hygiene, Cooperative Department of Veterinary Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    J Vet Med Sci 76:985-91. 2014
    ..In this study, to clarify the roles of SAA3 in the intestine, we characterized mRNA expression in mouse colonic epithelial CMT-93 cells treated with rotavirus, ..
  22. pmc Serum amyloid A is a retinol binding protein that transports retinol during bacterial infection
    MEHABAW G DEREBE
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, United States
    elife 3:e03206. 2014
    ..We determined the crystal structure of mouse SAA3 at a resolution of 2 Å, finding that it forms a tetramer with a hydrophobic binding pocket that can accommodate ..
  23. pmc Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice
    Laura J den Hartigh
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 9:e108564. 2014
    ..b>SAA3, an inducible form of SAA, is highly expressed in adipose tissue in obese mice where it promotes monocyte ..
  24. pmc Acute-phase protein serum amyloid A3 is a novel paracrine coupling factor that controls bone homeostasis
    Roman Thaler
    Ludwig Boltzmann Institute of Osteology, Wiener Gebietskrankenkasse and Allgemeine Unfallversicherungsanstalt, Trauma Center Meidling, 1st Medical Department, Hanusch Hospital, Vienna, Austria and Departments of Orthopedic Surgery and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA
    FASEB J 29:1344-59. 2015
    Serum amyloid A (A-SAA/Saa3) was shown before to affect osteoblastic metabolism...
  25. pmc Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts
    Shilpa Choudhary
    New England Musculoskeletal Institute, University of Connecticut Health, Farmington, Connecticut 06030 From the Departments of Medicine and
    J Biol Chem 291:3882-94. 2016
    ..Inhibition was reversed by pertussis toxin (PTX), which blocks Gαi/o activation. Saa3 was the most highly differentially expressed gene in a microarray comparison of RANKL-treated WT versus Cox2 KO ..
  26. pmc Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A
    Jin Liu
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China
    J Neuroinflammation 13:28. 2016
    ..Serum amyloid A (SAA), an acute-phase protein with cytokine-like property, has been implicated in amyloid deposition. It remains unclear whether SAA affects tau hyperphosphorylation...
  27. pmc Interaction of adenosine 3',5'-cyclic monophosphate and tumor necrosis factor-alpha on serum amyloid A3 expression in mouse granulosa cells: dependence on CCAAT-enhancing binding protein-beta isoform
    Deok Soo Son
    Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, TN 37208, USA
    Endocrinology 151:3407-19. 2010
    ..Because ovulation is an inflammatory reaction and TNF specifically induces serum amyloid A3 (SAA3) in mouse granulosa cells, the effect of cAMP on TNF-induced SAA3 promoter activity, mRNA and protein was ..
  28. ncbi Identification of mutations from phenotype-driven ENU mutagenesis in mouse chromosome 7
    Cymbeline T Culiat
    Life Sciences Division, Oak Ridge National Laboratory, Bethel Valley Road, P O Box 2008, Oak Ridge, Tennessee, 37831 6445, USA
    Mamm Genome 16:555-66. 2005
    ..Our data demonstrate that rapid mutation scanning with TGCE, followed by sequence verification only of detected positives, is an efficient approach to the identification of point mutations in the mouse genome...
  29. pmc Induction of the mouse serum amyloid A3 gene by cytokines requires both C/EBP family proteins and a novel constitutive nuclear factor
    J H Huang
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Mol Cell Biol 14:4475-84. 1994
    ..We have previously demonstrated that a 350-bp promoter fragment from the mouse SAA3 gene was necessary and sufficient to confer liver-specific and cytokine-induced expression...
  30. pmc Murine serum amyloid A3 is a high density apolipoprotein and is secreted by macrophages
    R L Meek
    Department of Pathology, University of Washington, Seattle 98195
    Proc Natl Acad Sci U S A 89:7949-52. 1992
    ..b>SAA3 is a unique member of the SAA multigene family in mice in that its mRNA is also expressed in extrahepatic tissues ..
  31. pmc The sequence and structure of a new serum amyloid A gene
    R S Stearman
    Nucleic Acids Res 14:797-809. 1986
    ..The sequence of the cDNA, the gene's exons and neighboring DNA are presented along with the mapping evidence supporting the gene structure...
  32. pmc Regulation of amyloid A gene expression in cultured cells
    H Y Rienhoff
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Mol Cell Biol 8:3710-6. 1988
    ..We report here the characterization of a cell line derived from mouse liver (BNL) in which the expression of SAA3 mRNA is regulated...
  33. ncbi Diverse gene expression for isotypes of murine serum amyloid A protein during acute phase reaction
    K Yamamoto
    Science 232:227-9. 1986
    ..Thus, the study emphasizes the importance of SAA gene structure in determining susceptibility to amyloidosis...
  34. ncbi Structural diversity of murine serum amyloid A genes. Evolutionary implications
    K Yamamoto
    J Immunol 139:1683-8. 1987
    ..comparison also shows that one (SAA4) of the other two genes is related to the SAA1/2 gene, whereas the other gene (SAA3) evolved independently. Based on these results and the SAA gene arrangement, we discussed mouse SAA gene evolution.
  35. ncbi Regulation of synthesis of amyloid A-related protein
    R S Stearman
    Ann N Y Acad Sci 389:106-15. 1982
    ..Little or no change is found after LPS administration. This suggests that other factors are responsible for the increase in SAAL mRNA in the acute phase response...
  36. ncbi The gene encoding the mouse serum amyloid A protein, apo-SAA5, maps to proximal chromosome 7
    A Butler
    Department of Genetics, Trinity College, University of Dublin, Ireland
    Immunogenetics 42:153-5. 1995
  37. ncbi Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1)
    H A Thompson
    Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 5224, USA
    Endocrinology 136:3037-45. 1995
    ..9 revealed it to encode a cDNA to serum amyloid A protein; consistent with this identification, expression of 6.9 mRNA was highly induced in both kidney and liver after treatment of mice with Escherichia coli lipopolysaccharide...
  38. ncbi Enhancement of murine serum amyloid A3 mRNA expression by glucocorticoids and its regulation by cytokines
    T Ishida
    Department of Pathology, Oita Medical University, Japan
    J Leukoc Biol 56:797-806. 1994
    ..We examined the effects of glucocorticoids (GC) on serum amyloid A (SAA) mRNA expression using an antisense SAA3 probe, and found that dexamethasone (DEX) and triamcinolone (TC) increased SAA3 mRNA expression by macrophage cell ..
  39. ncbi Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages
    L A Meheus
    Innogenetics N V, Industripark Zwijnaarde, Belgium
    J Immunol 151:1535-47. 1993
    ..Control experiments argue against the obvious explanation that the latter observation is caused solely by cellular leakage...
  40. ncbi The differential induction of alpha 1-acid glycoprotein and serum amyloid A genes by heavy metals
    M Yiangou
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77550
    Biochim Biophys Acta 1174:123-32. 1993
    ..CRP is another member of this family. Furthermore, our data suggest that the mechanism is not directly mediated by glucocorticoid or cytokine induction pathways...
  41. ncbi Structure of the mouse Saa4 gene and its linkage to the serum amyloid A gene family
    M C De Beer
    Department of Biochemistry, University of Kentucky Medical Center, Lexington, Kentucky, 40536, USA
    Genomics 34:139-42. 1996
    ..produced and can become the major apolipoprotein on HDL (SAA1, SAA2); (ii) a peripherally produced acute phase SAA3 that is only a minor HDL apolipoprotein; and (iii) a constitutive subfamily (SAA4) that is a minor normal HDL ..
  42. ncbi Mapping of the mouse serum amyloid A gene cluster by long-range polymerase chain reaction
    A Butler
    Department of Genetics and Biotechnology Institute, Trinity College, University of Dublin, Dublin 2, Ireland
    Immunogenetics 44:468-74. 1996
    ..complete map of the mouse Saa genes, defining a linkage group of 3'-Saa2-5'/5'-Saa1-3'/5'-Saa4-3'/5'-Saa5-3'/5'-+ ++Saa3-3', with a maximum size of 45 kilobases (kb)...
  43. pmc Serum amyloid A gene expression in rabbit, mink and mouse
    G Marhaug
    Department of Paediatrics, Washington University School of Medicine, St Louis, MO, USA
    Clin Exp Immunol 107:425-34. 1997
    ..In extrahepatic organs of the mink, no SAA mRNA was detectable in unstimulated animals, while the convoluted tubules of the kidney and uterine endometrium were strongly positive after systemic LPS injection...
  44. ncbi Functional analysis of a minimal mouse serum amyloid A3 promoter in transgenic mice
    H Wang
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Amyloid 8:250-6. 2001
    We report the generation of transgenic mice harboring the SAA3/LacZ transgene and analysis of its expression patterns in vivo following LPS-induced inflammation...
  45. ncbi Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6
    Qing Zhang
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 33:145-53. 2003
    ..Both genes are previously unknown and are found only in higher eukaryotes, and together represent a new class of genes that have evolved in higher organisms to govern the synthesis of highly specialized lysosome-related organelles...
  46. ncbi Identification of FGF10 targets in the embryonic lung epithelium during bud morphogenesis
    JINING LU
    Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 280:4834-41. 2005
    ..Our approach identifies Fgf10 targets that are common to multiple biological processes and provides insights into potential mechanisms by which Fgf signaling regulates epithelial cell behavior...

Research Grants1

  1. Mutagenesis of the Mammalian Imprinting Process(es)
    Eugene Rinchik; Fiscal Year: 2002
    ..abstract_text> ..