Ryr1

Summary

Gene Symbol: Ryr1
Description: ryanodine receptor 1, skeletal muscle
Alias: AI528790, RYR-1, Ryr, skrr, ryanodine receptor 1, calcium release channel, skeletal muscle calcium release channel, skeletal muscle ryanodine receptor, skeletal muscle-type ryanodine receptor, type 1 ryanodine receptor
Species: mouse

Top Publications

  1. ncbi The membrane skeleton of human erythrocytes and its implications for more complex cells
    V Bennett
    Annu Rev Biochem 54:273-304. 1985
  2. pmc Abnormal junctions between surface membrane and sarcoplasmic reticulum in skeletal muscle with a mutation targeted to the ryanodine receptor
    H Takekura
    Department of Physiology, National Institute of Fitness and Sports, Kagoshima, Japan
    Proc Natl Acad Sci U S A 92:3381-5. 1995
  3. pmc A transgenic myogenic cell line lacking ryanodine receptor protein for homologous expression studies: reconstitution of Ry1R protein and function
    R A Moore
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Cell Biol 140:843-51. 1998
  4. ncbi Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion
    James D Johnson
    Division of Metabolism, Department of Internal Medicine, Washington University School of Medicine, Box 8126, 8831 Wohl Clinic, 660 S Euclid, St Louis, MO 63110, USA
    FASEB J 18:878-80. 2004
  5. ncbi Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations
    Tianzhong Yang
    Department of Anesthesiology Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:37471-8. 2007
  6. ncbi A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation
    Cecilia Hidalgo
    Centro FONDAP de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Casilla 70005, Santiago 7, Chile
    J Biol Chem 281:26473-82. 2006
  7. ncbi Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1
    Takashi Kimura
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia
    Hum Mol Genet 14:2189-200. 2005
  8. ncbi Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors
    Zhiguang Yuchi
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada
    Channels (Austin) 5:120-3. 2011
  9. pmc Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells
    Xiao Qiang Li
    Center for Cardiovascular Sciences MC 8, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Pflugers Arch 457:771-83. 2009
  10. pmc Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors
    T Ikemoto
    Department of Pharmacology, Saitama Medical School, Japan
    J Physiol 501:305-12. 1997

Research Grants

Scientific Experts

Detail Information

Publications111 found, 100 shown here

  1. ncbi The membrane skeleton of human erythrocytes and its implications for more complex cells
    V Bennett
    Annu Rev Biochem 54:273-304. 1985
  2. pmc Abnormal junctions between surface membrane and sarcoplasmic reticulum in skeletal muscle with a mutation targeted to the ryanodine receptor
    H Takekura
    Department of Physiology, National Institute of Fitness and Sports, Kagoshima, Japan
    Proc Natl Acad Sci U S A 92:3381-5. 1995
    ..Since junctions form in the absence of feet and tetrads, coupling of SR to surface membrane and T tubules appears to be mediated by additional proteins, distinct from either RyRs or DHPRs...
  3. pmc A transgenic myogenic cell line lacking ryanodine receptor protein for homologous expression studies: reconstitution of Ry1R protein and function
    R A Moore
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Cell Biol 140:843-51. 1998
    CCS embryonic stem (ES) cells possessing two mutant alleles (ry1r-/ry1r-) for the skeletal muscle ryanodine receptor (RyR) have been produced and injected subcutaneously into severely compromised immunodeficient mice to produce ..
  4. ncbi Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion
    James D Johnson
    Division of Metabolism, Department of Internal Medicine, Washington University School of Medicine, Box 8126, 8831 Wohl Clinic, 660 S Euclid, St Louis, MO 63110, USA
    FASEB J 18:878-80. 2004
    ..In diabetes, the expression and function of ryanodine receptor (RyR) Ca2+ release channels are reduced...
  5. ncbi Enhanced excitation-coupled calcium entry in myotubes is associated with expression of RyR1 malignant hyperthermia mutations
    Tianzhong Yang
    Department of Anesthesiology Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 282:37471-8. 2007
    Myotubes expressing wild type RyR1 (WT) or RyR1 with one of three malignant hyperthermia mutations R615C, R2163C, and T4826I (MH) were exposed sequentially to 60 mm KCl in Ca(2+)-replete and Ca(2+)-free external buffers (Ca+ and Ca-, ..
  6. ncbi A transverse tubule NADPH oxidase activity stimulates calcium release from isolated triads via ryanodine receptor type 1 S -glutathionylation
    Cecilia Hidalgo
    Centro FONDAP de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Casilla 70005, Santiago 7, Chile
    J Biol Chem 281:26473-82. 2006
    ..NADPH enhanced the activity of ryanodine receptor type 1 (RyR1) in triads, measured through [3H]ryanodine binding and calcium release kinetics, and increased significantly RyR1 S-..
  7. ncbi Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1
    Takashi Kimura
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra ACT 2601, Australia
    Hum Mol Genet 14:2189-200. 2005
    ..we investigated the alternative splicing of mRNAs of two major proteins of the sarcoplasmic reticulum, the ryanodine receptor 1 (RyR1) and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) 1 or 2...
  8. ncbi Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors
    Zhiguang Yuchi
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada
    Channels (Austin) 5:120-3. 2011
    ..We recently described the crystal structure of the RyR1 N-terminal disease hot spot...
  9. pmc Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells
    Xiao Qiang Li
    Center for Cardiovascular Sciences MC 8, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    Pflugers Arch 457:771-83. 2009
    b>Ryanodine receptor 1 (RyR1) is well-known to be expressed in systemic and pulmonary vascular smooth muscle cells (SMCs); however, its functional roles remain largely unknown...
  10. pmc Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors
    T Ikemoto
    Department of Pharmacology, Saitama Medical School, Japan
    J Physiol 501:305-12. 1997
    1. We generated mice with targeted disruptions in the genes for both ryanodine receptor type 1 (RyR-1) and type 3 (RyR-3) to study the functional roles of RyR subtypes in skeletal muscle. 2...
  11. pmc Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers
    B E Flucher
    Department of Physiology, University of Innsbruck, A 6020 Innsbruck, Austria
    J Cell Biol 146:621-30. 1999
    The type 3 ryanodine receptor (RyR3) is a ubiquitous calcium release channel that has recently been found in mammalian skeletal muscles...
  12. ncbi The Ca2+ channel alpha2delta-1 subunit determines Ca2+ current kinetics in skeletal muscle but not targeting of alpha1S or excitation-contraction coupling
    Gerald J Obermair
    Department of Physiology and Medical Physics, Innsbruck Medical University, Austria
    J Biol Chem 280:2229-37. 2005
    ..However, this subunit is not essential for targeting of Ca(2+) channels or for their primary physiological role in activating skeletal muscle excitation-contraction coupling...
  13. ncbi Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling
    Gisela Beutner
    Department of Pharmacology and Physiology, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    Biochim Biophys Acta 1717:1-10. 2005
    ..Using subtype specific antibodies, we characterized the mRyR in the IMM from rat heart as RyR1. These results are substantiated by the absence of RyR protein in heart mitochondria from RyR1 knockout mice...
  14. ncbi Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol
    James D Fessenden
    Department of Anesthesia Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 281:21022-31. 2006
    The ryanodine receptor type 1 (RyR1) and type 2 (RyR2), but not type 3 (RyR3), are efficiently activated by 4-chloro-m-cresol (4-CmC)...
  15. ncbi Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene
    H Takeshima
    International Institute for Advanced Studies, Kyoto, Japan
    Nature 369:556-9. 1994
    ..We report here mice with a targeted mutation in the skeletal muscle ryanodine receptor gene...
  16. pmc The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues
    G Giannini
    European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 128:893-904. 1995
    ..In the testis, expression of RyR1 and RyR3 was detected in germ cells. RyR mRNAs were also detected in in vitro-cultured cell lines...
  17. ncbi Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor
    J Nakai
    Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan
    Nature 380:72-5. 1996
    ..The skeletal isoform of the ryanodine receptor (RyR-1) functions as the Ca2+-release channel and the dihydropyridine receptor (DHPR) functions as the voltage sensor ..
  18. ncbi Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells
    P Tarroni
    Dipartimento di Ricerca Biologica e Tecnologica DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    J Biol Chem 272:19808-13. 1997
    In vertebrate skeletal muscles, the type 1 isoform of ryanodine receptor (RyR1) is essential in triggering contraction by releasing Ca2+ from the sarcoplasmic reticulum in response to plasma membrane depolarisation...
  19. pmc Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles
    F Bertocchini
    DIBIT, San Raffaele Scientific Institute, Milano, Italy
    EMBO J 16:6956-63. 1997
    The skeletal isoform of Ca2+ release channel, RyR1, plays a central role in activation of skeletal muscle contraction...
  20. ncbi Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors
    V Barone
    DIBIT, San Raffaele Scientific Institute, Milan, Italy
    FEBS Lett 422:160-4. 1998
    ..muscle contraction is triggered by the release of Ca2+ from the sarcoplasmic reticulum through the type 1 ryanodine receptor (RyR1)...
  21. ncbi Correct targeting of dihydropyridine receptors and triadin in dyspedic mouse skeletal muscle in vivo
    H Takekura
    Department of Physiological Sciences, National Institute of Fitness and Sports, Kanoya, Kagoshima, Japan
    Dev Dyn 214:372-80. 1999
    ..the targeting of DHPRs and triadin to T-tubules and SR in skeletal muscles of dyspedic mouse embryos lacking RyR1. In normal differentiating muscle fibers DHPRs, triadin and RyRs are located in intensely immunolabeled foci that ..
  22. pmc Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca(2+) channel
    G Avila
    Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Gen Physiol 115:467-80. 2000
    ..muscle dihydropyridine receptor is markedly enhanced by the skeletal muscle isoform of the ryanodine receptor (RyR1) (Nakai, J., R.T. Dirksen, H. T. Nguyen, I.N. Pessah, K.G. Beam, and P.D. Allen. 1996. Nature. 380:72-75.)...
  23. ncbi Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle
    H Takekura
    Department of Physiological Sciences, National Institute of Fitness and Sports, Kanoya, Kagoshima, 891 2393, Japan
    Dev Biol 239:204-14. 2001
    ..They contain high concentrations of dihydropyridine receptors (DHPRs) in the T-tubules and of ryanodine receptors (RyR) in the SR and they are positioned at specific locations in the sarcomere...
  24. pmc The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation-contraction uncoupling in central core disease
    Guillermo Avila
    Department of Biochemistry, Cinvestav I P N, Zacatenco 07360, Mexico City, Mexico
    J Gen Physiol 121:277-86. 2003
    Human central core disease (CCD) is caused by mutations/deletions in the gene that encodes the skeletal muscle ryanodine receptor (RyR1)...
  25. ncbi Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling
    Tianzhong Yang
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 278:25722-30. 2003
    ..that segregates with >60 mutations within the MHS-1 locus on chromosome 19 coding for ryanodine receptor type 1 (RyR1)...
  26. ncbi The relative position of RyR feet and DHPR tetrads in skeletal muscle
    Cecilia Paolini
    University of Pennsylvania, Department of Cell and Developmental Biology, Philadelphia 19104 6058, USA
    J Mol Biol 342:145-53. 2004
    ..Four DHPRs linked to the four binding sites of the RyR1 cytoplasmic domain (or foot), define the corners of a square, constituting a tetrad...
  27. ncbi Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse
    Mihail G Chelu
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    FASEB J 20:329-30. 2006
    ..Mutation of tyrosine 522 of RyR1 (the predominant skeletal muscle calcium release channel) to serine has been associated with human malignant hyperthermia...
  28. ncbi Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse
    Tianzhong Yang
    Department of Anesthesia, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 105:1164-75. 2006
    ..In the majority of human cases and all cases in animals, malignant hyperthermia has been associated with missense mutations in the skeletal ryanodine receptor (RyR1).
  29. pmc An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line
    Elena Zvaritch
    Banting and Best Department of Medical Research, University of Toronto, Charles H Best Institute, 112 College Street, Toronto, ON, Canada
    Proc Natl Acad Sci U S A 104:18537-42. 2007
    A heterozygous Ile4898 to Thr (I4898T) mutation in the human type 1 ryanodine receptor/Ca(2+) release channel (RyR1) leads to a severe form of central core disease...
  30. pmc RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    William J Durham
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 133:53-65. 2008
    Mice with a malignant hyperthermia mutation (Y522S) in the ryanodine receptor (RyR1) display muscle contractures, rhabdomyolysis, and death in response to elevated environmental temperatures...
  31. pmc The alpha(1S) III-IV loop influences 1,4-dihydropyridine receptor gating but is not directly involved in excitation-contraction coupling interactions with the type 1 ryanodine receptor
    Roger A Bannister
    Department of Physiology and Biophysics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 283:23217-23. 2008
    In skeletal muscle, coupling between the 1,4-dihydropyridine receptor (DHPR) and the type 1 ryanodine receptor (RyR1) underlies excitation-contraction (EC) coupling...
  32. pmc Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1
    Alla D Lyfenko
    Department of Physiology and Pharmacology, University of Rochester, Rochester, NY 14642, USA
    J Physiol 586:4815-24. 2008
    ..These results are the first to demonstrate that SOCE in skeletal muscle requires both STIM1 and Orai1 and that SOCE and ECCE represent two distinct molecular entities...
  33. pmc Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling
    Takashi Kimura
    Hyogo College of Medicine, 1 1 Mukogawa cho Nishinomiya, Hyogo 663 8501, Japan
    Cell Calcium 45:264-74. 2009
    Alternative splicing of ASI residues (Ala(3481)-Gln(3485)) in the skeletal muscle ryanodine receptor (RyR1) is developmentally regulated: the residues are present in adult ASI(+)RyR1, but absent in the juvenile ASI(-)RyR1 which is over-..
  34. pmc A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice
    Zoita Andronache
    Institute of Applied Physiology, Ulm University, D 89069 Ulm, Germany
    Proc Natl Acad Sci U S A 106:4531-6. 2009
    ..muscle, which primarily originates from genetic alterations in the Ca(2+) release channel (ryanodine receptor, RyR1) of the sarcoplasmic reticulum (SR)...
  35. pmc Ca2+ dysregulation in Ryr1(I4895T/wt) mice causes congenital myopathy with progressive formation of minicores, cores, and nemaline rods
    Elena Zvaritch
    Banting and Best Department of Medical Research, Charles H Best Institute, University of Toronto, Toronto, Ontario, Canada M5G 1L6
    Proc Natl Acad Sci U S A 106:21813-8. 2009
    ..IT/+) mice express a knockin mutation corresponding to the human I4898T EC-uncoupling mutation in the type 1 ryanodine receptor/Ca(2+) release channel (RyR1), which causes a severe form of central core disease (CCD)...
  36. pmc Characterization and temporal development of cores in a mouse model of malignant hyperthermia
    Simona Boncompagni
    Centro Scienze dell Invecchiamento, Department of Basic and Applied Medical Sciences, Interuniversity Institute of Myology, Università Gabriele d Annunzio, I 66013 Chieti, Italy
    Proc Natl Acad Sci U S A 106:21996-2001. 2009
    ..MH) and central core disease are related skeletal muscle diseases often linked to mutations in the type 1 ryanodine receptor (RYR1) gene, encoding for the Ca(2+) release channel of the sarcoplasmic reticulum (SR)...
  37. pmc A malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels
    Roger A Bannister
    Department of Physiology and Biophysics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
    J Gen Physiol 135:629-40. 2010
    ..Bidirectional communication between the 1,4-dihydropyridine receptor (DHPR) in the plasma membrane and the type 1 ryanodine receptor (RYR1) in the sarcoplasmic reticulum (SR) is responsible for both skeletal-type excitation-contraction ..
  38. pmc A malignant hyperthermia-inducing mutation in RYR1 (R163C): alterations in Ca2+ entry, release, and retrograde signaling to the DHPR
    Eric Esteve
    Department of Anesthesiology Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Gen Physiol 135:619-28. 2010
    ..1,4-dihydropyridine receptor [DHPR]) and the sarcoplasmic reticulum (SR) Ca(2+) release channel (type 1 ryanodine receptor [RYR1]) of skeletal muscle is essential for excitation-contraction coupling (ECC) and is a well-..
  39. pmc The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging
    Simona Boncompagni
    IIM Interuniversitary Institute of Myology, DNI Department of Neuroscience and Imaging, Ce S I Centro Scienze dell Invecchiamento, University of Studi G d Annunzio, 66013 Chieti, Italy
    Aging Cell 9:958-70. 2010
    The I4898T (IT) mutation in type 1 ryanodine receptor (RyR1), the Ca(2+) release channel of the sarcoplasmic reticulum (SR) is linked to a form of central core disease (CCD) in humans and results in a nonleaky channel and excitation-..
  40. pmc Calcitonin gene-related peptide restores disrupted excitation-contraction coupling in myotubes expressing central core disease mutations in RyR1
    Ana Victoria Vega
    Department of Biochemistry, CINVESTAV IPN, Mexico City, DF, Mexico
    J Physiol 589:4649-69. 2011
    ..core disease (CCD) is a congenital human myopathy associated with mutations in the gene encoding the skeletal muscle ryanodine receptor (RyR1), resulting in skeletal muscle weakness and lower limb deformities...
  41. pmc Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres
    Romain Lefebvre
    CNRS UMR 5534, Universite Lyon 1, Centre de Génétique et de Physiologie Moléculaire et Cellulaire, Villeurbanne, France
    J Physiol 589:5361-82. 2011
    Mutations of the gene encoding the type 1 ryanodine receptor (RyR1) are associated with skeletal muscle disorders including malignant hyperthermia susceptibility (MHS) and central core disease (CCD)...
  42. pmc AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
    Johanna T Lanner
    Department of Molecular Physiology and Biophysics Baylor College of Medicine, Houston, Texas, USA
    Nat Med 18:244-51. 2012
    Mice with a knock-in mutation (Y524S) in the type I ryanodine receptor (Ryr1), a mutation analogous to the Y522S mutation that is associated with malignant hyperthermia in humans, die when exposed to short periods of temperature elevation ..
  43. pmc Temperature and RyR1 regulate the activation rate of store-operated Ca²+ entry current in myotubes
    Viktor Yarotskyy
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, USA
    Biophys J 103:202-11. 2012
    ..myotubes, as well as the regulation of its rate of activation by temperature and the type I ryanodine receptor (RyR1)...
  44. pmc Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor
    H Takeshima
    Department of Neurochemistry, Tokyo Institute of Psychiatry, Japan
    EMBO J 14:2999-3006. 1995
    While subtypes 1 and 2 of the ryanodine receptor (RyR) function as intracellular Ca2+ release channels, little is known about the function of the third subtype (RyR-3), first identified in brain...
  45. pmc Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling
    R G Gregg
    Waisman Center, University of Wisconsin, Madison 53705, USA
    Proc Natl Acad Sci U S A 93:13961-6. 1996
    ....
  46. ncbi Dyspedic mouse skeletal muscle expresses major elements of the triadic junction but lacks detectable ryanodine receptor protein and function
    E D Buck
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    J Biol Chem 272:7360-7. 1997
    ..Dyspedic mice and cells derived from them serve as excellent homologous expression systems in which to study how Ry1R structure relates to function...
  47. ncbi Molecular identification of the ryanodine receptor pore-forming segment
    M Zhao
    Cardiovascular Research Group, Department of Physiology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 274:25971-4. 1999
    ..These data suggest that this conserved region constitutes an essential part of the ryanodine binding site and the channel conduction pathway of the ryanodine receptor...
  48. pmc Ryanodine modification of RyR1 retrogradely affects L-type Ca(2+) channel gating in skeletal muscle
    R A Bannister
    Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, RC 1, North Tower, Aurora, CO 80045, USA
    J Muscle Res Cell Motil 30:217-23. 2009
    ..Ca(2+) channel (1,4-dihydropyridine receptor; DHPR) and the type 1 ryanodine-sensitive Ca(2+) release channel (RyR1) of the sarcoplasmic reticulum (SR). In the case of "orthograde signalling" (i.e...
  49. pmc Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor
    A Fleig
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    J Physiol 496:339-45. 1996
    ..skeletal myoballs cultured from wild-type and transgenic mice expressing a null mutation of the ryanodine receptor (RyR) type 1 (dyspedic myoballs). 2...
  50. ncbi Construction of a 1.2-Mb BAC/PAC contig of the porcine gene RYR1 region on SSC 6q1.2 and comparative analysis with HSA 19q13.13
    Flávia Martins-Wess
    Institute of Animal Breeding and Genetics, School of Veterinary Medicine Hannover, Bunteweg 17p, Hannover, Germany
    Genomics 80:416-22. 2002
    ..2-Mb BAC/PAC contig of the ryanodine receptor-1 gene (RYR1) region on porcine chromosome (SSC) 6q1.2...
  51. ncbi Intracellular calcium-release channels: regulators of cell life and death
    A R Marks
    Cardiovascular Institute, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Am J Physiol 272:H597-605. 1997
    ..Three forms of RyR have been identified: RyR1, expressed predominantly in skeletal muscle; RyR2, expressed predominantly in cardiac muscle; and RyR3, expressed ..
  52. ncbi SPRY domains in ryanodine receptors (Ca(2+)-release channels)
    C Ponting
    Fibrinolysis Research Unit, University of Oxford, UK
    Trends Biochem Sci 22:193-4. 1997
  53. ncbi Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain
    F Mori
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neurosci Lett 285:57-60. 2000
    ..Ca(2+)-induced Ca(2+) release channels located on the endoplasmic reticulum, and consist of three isoforms, termed RyR1-3. We examined their expression in developing mouse brains by in situ hybridization...
  54. ncbi Identification of functional type 1 ryanodine receptors in mouse dendritic cells
    Peta J O'Connell
    The John P Roberts Research Institute, London, Canada
    FEBS Lett 512:67-70. 2002
    ..Thus, the RyR1 channel may play an intrinsic role in Ca(2+) signaling in DC.
  55. ncbi Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency
    Wei Tang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 18:1597-9. 2004
    The immunophilin FKBP12 binds the skeletal muscle Ca2+ release channel or ryanodine receptor (RyR1), but the functional consequences of this interaction are not known...
  56. pmc Interaction between the dihydropyridine receptor Ca2+ channel beta-subunit and ryanodine receptor type 1 strengthens excitation-contraction coupling
    Weijun Cheng
    Department of Physiology, University of Wisconsin School of Medicine, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 102:19225-30. 2005
    ..1 (alpha1S) physically interacts with ryanodine receptor type 1 (RyR1), and a molecular signal is transmitted from alpha1S to RyR1 to trigger excitation-contraction (EC) coupling...
  57. pmc Epigenetic allele silencing unveils recessive RYR1 mutations in core myopathies
    Haiyan Zhou
    Dubowitz Neuromuscular Centre, Department of Paediatrics, Imperial College, Hammersmith Hospital London, United Kingdom
    Am J Hum Genet 79:859-68. 2006
    ..Mutations in the skeletal-muscle ryanodine-receptor gene (RYR1) are associated with malignant hyperthermia susceptibility and the congenital myopathies central core disease and ..
  58. pmc Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression
    Mirko Vukcevic
    Department of Anaesthesia, Basel University Hospital, 4031 Basel, Switzerland
    J Biol Chem 283:34913-22. 2008
    Dendritic cells express the skeletal muscle ryanodine receptor (RyR1), yet little is known concerning its physiological role and activation mechanism. Here we show that dendritic cells also express the Ca(v)1...
  59. pmc S100A1 and calmodulin regulation of ryanodine receptor in striated muscle
    Benjamin L Prosser
    Center for Biomedical Engineering and Technology BioMET, Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
    Cell Calcium 50:323-31. 2011
    ..We also discuss past, current and future work surrounding the regulation of ryanodine receptors by calmodulin and S100A1 in both cardiac and skeletal muscle, and the implications for excitation-contraction coupling...
  60. pmc Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy
    Mathieu Rederstorff
    Architecture et Reactivite de l ARN, Universite de Strasbourg, CNRS, IBMC, Strasbourg, France
    PLoS ONE 6:e23094. 2011
    ....
  61. pmc Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage
    Benjamin Yuen
    Department of Veterinary Molecular Biosciences, University of California, Davis, California, USA
    FASEB J 26:1311-22. 2012
    Mutation T4825I in the type 1 ryanodine receptor (RYR1(T4825I/+)) confers human malignant hyperthermia susceptibility (MHS). We report a knock-in mouse line that expresses the isogenetic mutation T4826I...
  62. pmc Fluorescence resonance energy transfer (FRET) indicates that association with the type I ryanodine receptor (RyR1) causes reorientation of multiple cytoplasmic domains of the dihydropyridine receptor (DHPR) α(1S) subunit
    Alexander Polster
    Department of Vegetative Physiology, University of Cologne, D 50931 Cologne, Germany
    J Biol Chem 287:41560-8. 2012
    ..channel and voltage sensor for excitation-contraction (EC) coupling, triggering Ca(2+) release via the type 1 ryanodine receptor (RyR1) in the sarcoplasmic reticulum (SR)...
  63. pmc Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia
    Jose M Eltit
    Department of Physiology and Biophysics, Virginia Commonwealth University, Richmond, Virginia, USA
    FASEB J 27:991-1000. 2013
    ..MH) susceptibility has been attributed to a leaky sarcoplasmic reticulum (SR) caused by missense mutations in RYR1 or CACNA1S, and the MH crisis has been attributed solely to massive self-sustaining release of Ca(2+) from SR ..
  64. pmc Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos
    M Gartz Hanson
    Department of Pediatrics University of Colorado School of Medicine and Children s Hospital Colorado, Aurora, CO 80045, United States Electronic address
    Dev Biol 404:76-87. 2015
    ..Through a forward genetic screen for muscle weakness, we recently reported an allele of ryanodine receptor type 1 (Ryr1(AG))...
  65. pmc FoxP1 orchestration of ASD-relevant signaling pathways in the striatum
    Daniel J Araujo
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 29:2081-96. 2015
    ..These data support an integral role for FoxP1 in regulating signaling pathways vulnerable in autism and the specific regulation of striatal pathways important for vocal communication. ..
  66. pmc Stac3 has a direct role in skeletal muscle-type excitation-contraction coupling that is disrupted by a myopathy-causing mutation
    Alexander Polster
    Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045
    Proc Natl Acad Sci U S A 113:10986-91. 2016
    In skeletal muscle, conformational coupling between CaV1.1 in the plasma membrane and type 1 ryanodine receptor (RyR1) in the sarcoplasmic reticulum (SR) is thought to underlie both excitation-contraction (EC) coupling Ca(2+) release ..
  67. pmc Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function
    Sho Kakizawa
    Department of Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    EMBO J 31:417-28. 2012
    ..Reversible S-nitrosylation of type 1 RyR (RyR1) triggers this Ca(2+) release...
  68. pmc Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation
    Malini Seth
    Department of Medicine, Duke University, Durham, North Carolina 27710, USA
    Dev Dyn 241:639-47. 2012
    ..These results suggest that SOCE regulates SR/ER specialization and that SLN and STIM1 act in opposing fashions to govern SOCE during myogenesis...
  69. ncbi Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12
    W Shou
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 391:489-92. 1998
    ..stoichiometrically with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor (RyR1)...
  70. ncbi Isolation of murine SPT5 homologue: completion of the isolation and characterization of human and murine homologues of yeast chromatin structural protein complex SPT4, SPT5, and SPT6
    P W Chiang
    Department of Pediatrics, University of Michigan Medical Center, Ann Arbor 48109, USA
    Genomics 47:426-8. 1998
  71. ncbi Intracellular calcium release channel expression during embryogenesis
    N Rosemblit
    Molecular Cardiology Program, Divisions of Circulatory Physiology and Cardiology, Department of Medicine, New York, New York, 10032, USA
    Dev Biol 206:163-77. 1999
    ..of intracellular calcium (Ca2+) via either inositol 1,4, 5-trisphosphate receptors (IP3R) or ryanodine receptors (RyR) activates a wide variety of signaling pathways in virtually every type of cell...
  72. ncbi Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis
    Bruce J Herron
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 30:185-9. 2002
    ..Using a hierarchical approach, it is possible to maximize the efficiency of this analysis so that it can be carried out easily with modest infrastructure and resources...
  73. ncbi Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex
    A V Faure
    Laboratoire Canaux Ioniques et Signalisation, INSERM E 9931, Departement de Biologie Moleculaire et Structurale, 17 rue des Martyrs, F 38054 Grenoble, France
    Eur J Neurosci 14:1613-22. 2001
    ..calcium release channels, namely the inositol trisphosphate receptors (IP3R) and the ryanodine receptors (RyR), were detected by their transcripts in the cerebral hemispheres, as early as stage E11...
  74. ncbi Long-term potentiation and long-term depression in hippocampal CA1 neurons of mice lacking the IP(3) type 1 receptor
    T Nagase
    Department of Physiology, Yamagata University School of Medicine, 990 9585, Yamagata, Japan
    Neuroscience 117:821-30. 2003
    ....
  75. ncbi Ca2+ influx through alpha1S DHPR may play a role in regulating Ca2+ release from RyR1 in skeletal muscle
    Alexander Shtifman
    Department of Anesthesia Research, Brigham and Women s Hospital, Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA
    Am J Physiol Cell Physiol 286:C73-8. 2004
    ..showed expression of both alpha1S dihydropyridine receptors (DHPRs) and ryanodine-sensitive Ca2+-release channel 1 (RyR1), the two key proteins in skeletal excitation-contraction (E-C) coupling...
  76. ncbi Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle
    Christopher W Ward
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 279:5781-7. 2004
    ..Recent work has demonstrated direct interaction of Homer proteins with type 1 and type 2 ryanodine receptor (RyR) isoforms...
  77. ncbi Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation
    Pieranna Chiarella
    Department of Histology and Medical Embryology and Centro di Eccellenza Biologia e Medicina Molecolare, University of Rome La Sapienza, Via A Scarpa 14, 00161 Roma, Italy
    J Cell Sci 117:4127-34. 2004
    ..b>RyR1 was expressed in spermatogonia, pachytene spermatocytes and round spermatids whereas RyR2 was found only in 5- to ..
  78. ncbi Fluorescence probe study of Ca2+-dependent interactions of calmodulin with calmodulin-binding peptides of the ryanodine receptor
    Jaya Pal Gangopadhyay
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    Biochem Biophys Res Commun 323:760-8. 2004
    ..Based on our results we propose that both the interaction interface and the global conformation of the CaM-CaMBP complex are altered by calcium...
  79. ncbi Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1
    James D Fessenden
    Department of Anesthesia Research, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Biol Chem 279:53028-35. 2004
    ..putative Ca(2+) binding motifs previously identified with Ca(2+) overlay binding analysis within the skeletal muscle ryanodine receptor isoform (RyR1) was examined using mutational analysis...
  80. ncbi Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction
    Wanglei Du
    Division of Pulmonary, Allergy and Critical Care Medicine, Duke University, Medical Center, Durham, North Carolina, 27710, USA
    J Biol Chem 280:26287-94. 2005
    ..Here we report that mouse ASMCs also express the skeletal muscle and brain isoforms of RyRs (RyR1 and RyR3, respectively)...
  81. ncbi Functional coupling between TRPC3 and RyR1 regulates the expressions of key triadic proteins
    Eun Hui Lee
    Laboratory of Calcium Communication, Department of Physiology, College of Medicine, The Catholic University of Korea, Seoul 137 701, Korea
    J Biol Chem 281:10042-8. 2006
    ..experiments, the gain of excitation-contraction coupling and the amplitude of the Ca(2+) release seen after direct RyR1 activation with caffeine was significantly reduced in TRPC3 KD...
  82. pmc Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy
    John D Lueck
    Department of Physiology and Pharmacology, University of Rochester, Rochester, NY 14642, USA
    J Gen Physiol 129:79-94. 2007
    ....
  83. ncbi Quantification of the effects of a ryanodine receptor channel mutation on interaction with a ryanoid
    Kishani M Ranatunga
    Cardiac Medicine, National Heart and Lung Institute, Imperial College London, London, UK
    Mol Membr Biol 24:185-93. 2007
    Understanding the nature of the interaction of the plant alkaloid ryanodine with its receptor channel (RyR) is important to aid interpretation of physiological studies and provide structure-function information about RyR...
  84. pmc S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling
    Benjamin L Prosser
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 283:5046-57. 2008
    ..This warrants further investigation into the use of S100A1 as a therapeutic target for the treatment of both cardiac and skeletal myopathies...
  85. pmc Calmodulin in adult mammalian skeletal muscle: localization and effect on sarcoplasmic reticulum Ca2+ release
    George G Rodney
    Department of Organizational Systems and Adult Health, University of Maryland School of Nursing, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 294:C1288-97. 2008
    ..Surprisingly, removal of endogenous calmodulin did not alter the time dependence of Ca2+ spark appearance. These results indicate that calmodulin may not be essential for RyR1-dependent Ca2+ release in adult mammalian skeletal muscle.
  86. doi Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study
    N Galeotti
    Department of Preclinical and Clinical Pharmacology, Viale G Pieraccini 6, I 50139 Florence, Italy
    Neuroscience 153:814-22. 2008
    ..A selective involvement of RyR1 and RyR3 in supraspinal muscarinic analgesia was demonstrated whereas RyR2 appears not to play an essential role in ..
  87. pmc Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death
    Dan S Luciani
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Comlumbia, Canada
    Diabetes 58:422-32. 2009
    ..Here, we examined the effects of stimulating or inhibiting the ER-resident inositol trisphosphate receptors (IP(3)Rs) and the ryanodine receptors (RyRs) on the induction of beta-cell ER stress and apoptosis...
  88. doi A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells
    Roberta Ribeiro Costa
    Department of Physiology, School of Medicine of Ribeirao Preto University of Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Am J Physiol Cell Physiol 299:C316-23. 2010
    ..These results not only broaden our understanding of the role played by calcium in Leydig cells but also show, for the first time, that RyRs have an important role in determining testosterone secretion by the testis...
  89. pmc Effects of conformational peptide probe DP4 on bidirectional signaling between DHPR and RyR1 calcium channels in voltage-clamped skeletal muscle fibers
    Rotimi O Olojo
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Biophys J 100:2367-77. 2011
    ..coupling involves the activation of dihydropyridine receptors (DHPR) and type-1 ryanodine receptors (RyR1) to produce depolarization-dependent sarcoplasmic reticulum Ca²⁺ release via orthograde signaling...
  90. pmc Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease
    Lan Wei
    University of Rochester Medical Center, Department of Pharmacology and Physiology, Rochester, NY 14642, USA
    FASEB J 25:3068-78. 2011
    ..9 ± 0.8 and 19.8 ± 2.6 flashes/1000 μm²·100 s at 23°C and 37°C) was observed in fibers from RYR1(Y522S/WT) mice, a mouse model of malignant hyperthermia and heat-induced hypermetabolism...
  91. ncbi Localization of the calcium release channel gene in cattle and horse by in situ hybridization: evidence of a conserved synteny with glucose phosphate isomerase
    B P Chowdhary
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala
    Anim Genet 23:43-50. 1992
    In situ hybridization techniques were used to localize regionally the calcium release channel (CRC) gene on cattle and horse chromosomes, using a porcine CRC cDNA probe...
  92. ncbi The halothane sensitivity locus and its linkage relationships
    A L Archibald
    Anim Blood Groups Biochem Genet 16:253-63. 1985
  93. pmc The organization of proteins in the human red blood cell membrane. A review
    T L Steck
    J Cell Biol 62:1-19. 1974
  94. ncbi Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs
    T Ayabe
    Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia 19104, USA
    Development 121:2233-44. 1995
    ..Results of these experiments suggest that although ryanodine receptors are present and functional, release of Ca2+ from this store is not essential for sperm-induced egg activation...
  95. ncbi Mapping the Hrc gene to proximal mouse chromosome 7: delineation of a conserved linkage group with human 19q
    S D Brown
    Department of Biochemistry and Molecular Genetics, St Mary s Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom
    Genomics 18:459-61. 1993
  96. ncbi Malignant hyperthermia: excitation-contraction coupling, Ca2+ release channel, and cell Ca2+ regulation defects
    J R Mickelson
    Department of Veterinary Pathobiology, University of Minnesota, St Paul, USA
    Physiol Rev 76:537-92. 1996
    ..In porcine MH, these studies identified the skeletal muscle sarcoplasmic reticulum Ca2+ release channel gene (RYR1) as the site of the defect...
  97. ncbi RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle
    D Yang
    Laboratory of Cardiovascular Science, Gerontology Research Center, NIA National Institutes of Health, Baltimore, MD 21224, USA
    J Biol Chem 276:40210-4. 2001
    The neonatal mammalian skeletal muscle contains both type 1 and type 3 ryanodine receptors (RyR1 and RyR3) located in the sarcoplasmic reticulum membrane...
  98. ncbi Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1
    Rao V L Papineni
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:49167-74. 2002
    Apocalmodulin and Ca(2+) calmodulin bind to overlapping sites on the ryanodine receptor skeletal form, RYR1, but have opposite functional effects on channel activity...
  99. ncbi FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells
    Yong Xiao Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    Am J Physiol Cell Physiol 286:C538-46. 2004
    ..6) associates with and regulates type 2 RyRs (RyR2) in tracheal smooth muscle. FKBP12.6 binds to RyR2 but not other RyR or inositol 1,4,5-trisphosphate receptors, and FKBP12, known to bind to and modulate skeletal RyRs, does not ..
  100. ncbi Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion
    Etsuko Yamamori
    Department of Medicine, Nagoya University Graduate School of Medicine and Hospital, Japan
    Endocrinology 145:36-8. 2004
    ..Expression of two ryanodine receptor subtypes (RyR1 and RyR3) was confirmed by RT-PCR...
  101. ncbi Dihydropyridine and ryanodine receptor binding after eccentric contractions in mouse skeletal muscle
    Christopher P Ingalls
    Muscle Biology Laboratory, Department of Kinesiology and Health, Georgia State University, Atlanta, GA 30303, USA
    J Appl Physiol (1985) 96:1619-25. 2004
    ..We also concluded that the loss in ryanodine receptors 3 days after injury is not the primary cause of excitation-contraction uncoupling at that time...

Research Grants9

  1. Antioxidants and oxidative damage in mitochondria
    Cecilia Giulivi; Fiscal Year: 2002
    ..The antioxidant effect of flavonoids, coumarins, and catechins will be studied in terms hydroxyl substitution, conjugation of rings, and o- methylation of hydroxyl groups to elucidate an association between structure and function. ..
  2. Regulation of Mitochondrial Nitric-oxide Synthase
    Cecilia Giulivi; Fiscal Year: 2003
    ..Studying the biochemistry of mtNOS will provide a better understanding of the role of nitric oxide in the cell-mitochondria interactions relevant to physiological situations. ..
  3. CHARACTERIZATION OF THE MURINE WAVED 3 MUTATION
    David Beier; Fiscal Year: 2004
    ..The combination of a positional cloning approach with a detailed characterization of the wa3 phenotype should provide insight into understanding genes that control normal skin development. ..
  4. Antioxidants and oxidative damage in mitochondria
    Cecilia Giulivi; Fiscal Year: 2004
    ..Structure-activity association of naturally occurring flavonoids in the abrogation of protein nitration, and 4. Bioavailability of flavonoids containing diets in nitrative stress. ..
  5. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2006
    ..Our preliminary studies, together with previous findings, suggest that specific RyR subtypes (RyR1, RyR2 and RyR3) are differentially expressed in the vasculature...
  6. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2007
    ..This novel signaling pathway, ADP-ribosyl cyclase-cADPR-FKBP12.6-RyR, may be hyper-functioned in asthma, contributing to the airway muscle Ca2+ and contractile hyperresponsiveness to ..
  7. Molecular mechanisms of RyR activation by 4-CmC
    JAMES FESSENDEN; Fiscal Year: 2007
    ..Research Plan: This proposal will examine a key modulator site on the skeletal muscle ryanodine receptor isoform (RyR1)...
  8. Analysis of Genetic Modifiers of PKD in the Mouse
    David Beier; Fiscal Year: 2008
    ..It is therefore an aim of this proposal to develop mutant mice that develop cysts as a consequence of loss of heterozygosity, using either a spontaneous or inducible system. ..
  9. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2010
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..