Runx2

Summary

Gene Symbol: Runx2
Description: runt related transcription factor 2
Alias: AML3, Cbf, Cbfa-1, Cbfa1, LS3, Osf2, PEBP2aA, Pebp2a1, Pebpa2a, runt-related transcription factor 2, AKV core binding factor, CBF-alpha-1, PEA2-alpha A, PEBP2 alpha A, SL3-3 enhancer factor 1 alpha A subunit, acute myeloid leukemia 3 protein, core binding factor alpha 1, osteoblast-specific transcription factor 2, polyomavirus enhancer-binding protein 2 alpha A subunit, runt domain, alpha subunit 1
Species: mouse

Top Publications

  1. ncbi Maturational disturbance of chondrocytes in Cbfa1-deficient mice
    M Inada
    Department of Medicine III, Osaka University Medical School, Japan
    Dev Dyn 214:279-90. 1999
  2. ncbi MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1
    G Xiao
    Department of Periodontics, Prevention, and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Biol Chem 275:4453-9. 2000
  3. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
  4. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
  5. ncbi The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002
  6. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
  7. ncbi Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues
    M Sato
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Oncogene 17:1517-25. 1998
  8. ncbi Regulation of chondrocyte differentiation by Cbfa1
    I S Kim
    Universitäts Kinderklinik Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany
    Mech Dev 80:159-70. 1999
  9. ncbi Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
    Guozhi Xiao
    Department of Periodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Biol Chem 277:36181-7. 2002
  10. ncbi Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005

Detail Information

Publications181 found, 100 shown here

  1. ncbi Maturational disturbance of chondrocytes in Cbfa1-deficient mice
    M Inada
    Department of Medicine III, Osaka University Medical School, Japan
    Dev Dyn 214:279-90. 1999
    b>Cbfa1, a transcription factor that belongs to the runt-domain gene family, plays an essential role in osteogenesis...
  2. ncbi MAPK pathways activate and phosphorylate the osteoblast-specific transcription factor, Cbfa1
    G Xiao
    Department of Periodontics, Prevention, and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Biol Chem 275:4453-9. 2000
    The bone-specific transcription factor, Cbfa1, regulates expression of the osteocalcin (OCN) gene and is essential for bone formation. However, little is known about the mechanisms regulating Cbfa1 activity...
  3. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
    A transcription factor, Cbfa1, which belongs to the runt-domain gene family, is expressed restrictively in fetal development. To elucidate the function of Cbfa1, we generated mice with a mutated Cbfa1 locus...
  4. ncbi Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation
    P Ducy
    Department of Molecular Genetics, M D Anderson Cancer Center, University of Texas, Houston 77030, USA
    Cell 89:747-54. 1997
    ..We have now cloned the cDNA encoding Osf2/Cbfa1, the protein that binds to OSE2...
  5. ncbi The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002
    ..These cells do, however, express Runx2/Cbfa1, another transcription factor required for bone formation...
  6. ncbi MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    Michael A Arnold
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 12:377-89. 2007
    ..These findings reveal unexpected commonalities in the mechanisms governing muscle, cardiovascular, and bone development with respect to their regulation by MEF2 and class II HDACs...
  7. ncbi Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues
    M Sato
    Department of Pathology, Osaka University Medical School, Suita, Japan
    Oncogene 17:1517-25. 1998
    ..The overlapping localization of opn and PEBP2alphaA/CBFA1 mRNA, and the marked decrease of opn mRNA expression in PEBP2alphaA knockout mice, indicated that the ..
  8. ncbi Regulation of chondrocyte differentiation by Cbfa1
    I S Kim
    Universitäts Kinderklinik Mainz, Langenbeckstrasse 1, 55101, Mainz, Germany
    Mech Dev 80:159-70. 1999
    b>Cbfa1, a developmentally expressed transcription factor of the runt family, was recently shown to be essential for osteoblast differentiation...
  9. ncbi Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2
    Guozhi Xiao
    Department of Periodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Biol Chem 277:36181-7. 2002
    ..We showed recently that this pathway is important for activation and phosphorylation of Cbfa1/Runx2, an osteoblast-related transcription factor (Xiao, G., Jiang, D., Thomas, P., Benson, M. D., Guan, K...
  10. ncbi Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation
    Donald A Glass
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
    Dev Cell 8:751-64. 2005
    ....
  11. ncbi Transcriptional mechanisms in osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Trends Genet 19:458-66. 2003
    ..b>Runx2 and Osx, a newly identified zinc-finger-containing protein, are transcription factors that are expressed ..
  12. pmc Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
    W Liu
    Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Cell Biol 155:157-66. 2001
    Targeted disruption of core binding factor alpha1 (Cbfa1) showed that Cbfa1 is an essential transcription factor in osteoblast differentiation and bone formation...
  13. ncbi Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault
    Mamoru Ishii
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9176, USA
    Development 130:6131-42. 2003
    ..Molecular epistasis analysis suggests that Msx2 and Twist do not act in tandem to control osteoblast differentiation, but function at the same epistatic level...
  14. ncbi A twist code determines the onset of osteoblast differentiation
    Peter Bialek
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 6:423-35. 2004
    b>Runx2 is necessary and sufficient for osteoblast differentiation, yet its expression precedes the appearance of osteoblasts by 4 days. Here we show that Twist proteins transiently inhibit Runx2 function during skeletogenesis...
  15. ncbi Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression
    Tripti Gaur
    Department of Cell Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655 0106, USA
    J Biol Chem 280:33132-40. 2005
    ..Here, we address the hypothesis that canonical WNT signaling and the bone-related transcription factor RUNX2/CBFA1/AML3 are functionally linked components of a pathway required for the onset of osteoblast differentiation...
  16. ncbi TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
    Jeong Ho Hong
    Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18 580, Cambridge, MA 02139, USA
    Science 309:1074-8. 2005
    ..Two key transcription factors, Runx2 and peroxisome proliferator-activated receptor gamma (PPARgamma), drive MSCs to differentiate into either ..
  17. pmc Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes
    C Ueta
    Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Cell Biol 153:87-100. 2001
    ..However, the mechanism by which cartilage phenotype is specified remains unclarified. Core binding factor alpha1 (Cbfa1) is an essential transcription factor for osteoblast differentiation and bone formation and has the ability to ..
  18. ncbi The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen
    C Tribioli
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Development 126:5699-711. 1999
    ..of several molecular markers required for normal chondroblast differentiation (&agr; 1(II) collagen, Fgfr3, Osf2, Indian hedgehog, Sox9), as well as a chondrocyte-specific alpha1 (II) collagen-lacZ transgene...
  19. pmc Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation
    Anne L Jacob
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 296:315-28. 2006
    ..These data demonstrate that signaling through FGFR1 in osteoblasts is necessary to maintain the balance between bone formation and remodeling through a direct effect on osteoblast maturation...
  20. pmc Cilia-like structures and polycystin-1 in osteoblasts/osteocytes and associated abnormalities in skeletogenesis and Runx2 expression
    Zhousheng Xiao
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 281:30884-95. 2006
    ..Heterozygous and homozygous Pkd1m1Bei mutant mice displayed a gene dose-dependent decrease in the expression of Runx2 and osteoblast-related genes...
  21. ncbi Runx2 determines bone maturity and turnover rate in postnatal bone development and is involved in bone loss in estrogen deficiency
    Zenjiro Maruyama
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Dev Dyn 236:1876-90. 2007
    b>Runx2 is an essential transcription factor for osteoblast differentiation. However, the functions of Runx2 in postnatal bone development remain to be clarified...
  22. pmc Expression of Runx2 transcription factor in non-skeletal tissues, sperm and brain
    Jae Hwan Jeong
    Department of Biochemistry and Cell Biology, School of Medicine, Cell and Matrix Research Institute, Skeletal Diseases Genome Research Center, Kyungpook National University, Daegu, Republic of Korea
    J Cell Physiol 217:511-7. 2008
    b>Runx2 is a master transcription factor for chondrocyte and osteoblast differentiation and bone formation. However expression of Runx2 (by RT-PCR), has been reported in non-skeletal tissues such as breast, T cells and testis...
  23. doi Transactivation by Runt related factor-2 of matrix metalloproteinase-13 in astrocytes
    Takeshi Takarada
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    Neurosci Lett 451:99-104. 2009
    ..expression was invariably seen for the master regulator of osteoblastic differentiation Runt related factor-2 (Runx2), in addition to the partner protein core binding factor-beta and their targets such as osteopontin (OPN) and ..
  24. ncbi Cell growth regulatory role of Runx2 during proliferative expansion of preosteoblasts
    Jitesh Pratap
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Cancer Res 63:5357-62. 2003
    The Runx2 (CBFA1/AML3/PEBP2alphaA) transcription factor promotes lineage commitment and differentiation by activating bone phenotypic genes in postproliferative osteoblasts...
  25. ncbi Cbf beta regulates Runx2 function isoform-dependently in postnatal bone development
    Naoko Kanatani
    Department of Developmental and Reconstructive Medicine, Division of Cell Biology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8588, Japan
    Dev Biol 296:48-61. 2006
    b>Runx2 and Cbfbeta are essential for skeletal development during the embryonic stage. Runx2 has two isoforms with different N-termini. We examined the functions of the Runx2 isoforms and Cbfbeta in postnatal bone development...
  26. pmc Sclerostin is a direct target of osteoblast-specific transcription factor osterix
    Fan Yang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Biochem Biophys Res Commun 400:684-8. 2010
    ..Taken together, these findings support our hypothesis that Sost is a direct target of Osx. This provides a new additional mechanism through which Osx inhibits Wnt signaling during bone formation...
  27. ncbi Cbfa1 is a positive regulatory factor in chondrocyte maturation
    H Enomoto
    Department of Molecular Medicine, Osaka University Medical School, 2 2 Yamada Oka Suita, Osaka 565 0871, Japan
    J Biol Chem 275:8695-702. 2000
    b>Cbfa1 is a transcription factor that belongs to the runt domain gene family...
  28. ncbi Cbfa1: a molecular switch in osteoblast biology
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Dyn 219:461-71. 2000
    ..of osteoblast biology has made rapid progress due to the characterization of the function of one molecule, Cbfa1. This member of the runt/Cbfa family of transcription factors was first identified as the nuclear protein binding ..
  29. ncbi The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1
    Ryuji Ikeda
    Division of Genetic Diagnosis, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 280:8523-30. 2005
    ..of osteoblast-specific genes such as the alkaline phosphatase, collagen 1A1 (Col1a1), Runx2/core-binding factor 1 (Cbfa1), and osteocalcin genes, even in the presence of OS in hMSCs...
  30. pmc Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes
    Satoshi Yamashita
    Department of Systems Biomedicine, National Research Institute of Child Health and Development, Tokyo 157 8535, Japan
    Exp Cell Res 315:2231-40. 2009
    ..by Sox9 on late-stage chondrogenesis partially results from the inhibition of Runt-related transcription factor 2 (Runx2), the main activator of hypertrophic chondrocyte differentiation...
  31. ncbi Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
    I Satokata
    Genetics Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Nat Genet 24:391-5. 2000
    ..Our results provide a developmental basis for PFM and demonstrate that Msx2 is essential at multiple sites during organogenesis...
  32. pmc Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells
    Toru Tanaka
    Department of Medicine and Biological Science, Gunma University Graduate School of Medicine, 3 39 15, Showa machi, Maebashi, Gunma 371 8511, Japan
    Mol Cell Biol 28:1147-60. 2008
    ..Although Runx2, a key osteogenic transcription factor, is expressed in atherosclerotic plaques, the molecular mechanisms by which ..
  33. ncbi Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice
    WenFang Wang
    Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02215, USA
    Dev Biol 270:364-81. 2004
    Runx2-Cbfa1, a Runt transcription factor, plays important roles during skeletal development. It is required for differentiation and function of osteoblasts...
  34. pmc Polycystin-1 regulates skeletogenesis through stimulation of the osteoblast-specific transcription factor RUNX2-II
    Zhousheng Xiao
    Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 283:12624-34. 2008
    ..PC1) may play an important role in skeletogenesis through regulation of the bone-specific transcription factor Runx2-II...
  35. pmc Role of Indian hedgehog signaling in palatal osteogenesis
    Benjamin Levi
    Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, Calif, USA
    Plast Reconstr Surg 127:1182-90. 2011
    ..The authors hypothesize that Indian hedgehog activity plays a role in osteogenesis within the secondary palate and that defects in this pathway may inhibit osteogenesis of the secondary palate...
  36. ncbi Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 111:621-33. 2002
    ..Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes...
  37. ncbi Runx2-mediated regulation of the zinc finger Osterix/Sp7 gene
    Yasuhiko Nishio
    Center for Musculoskeletal Research, Department of Orthopaedics, Box 665, University of Rochester Medical Center, Rochester, NY 14642, USA
    Gene 372:62-70. 2006
    ..8 and 2 kb. Over-expression experiments indicate that Runx2 significantly transactivates the Osx promoter by at least 2 fold indicating that Osx is downstream of Runx2 in ..
  38. ncbi Identification of USF2 as a key regulator of Runx2 expression in mouse pluripotent mesenchymal D1 cells
    Chihuei Wang
    Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan
    Mol Cell Biochem 292:79-88. 2006
    b>Runx2 is one of the most important transcription factors directing the osteogenesis of mesenchymal stem cells and osteoblastic functions...
  39. doi The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease
    Shingo Sato
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 58:2764-75. 2008
    b>Runx2 is a transcription factor that regulates chondrocyte differentiation...
  40. pmc Runx1 and Runx2 cooperate during sternal morphogenesis
    Ayako Kimura
    Department of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Development 137:1159-67. 2010
    Chondrocyte differentiation is strictly regulated by various transcription factors, including Runx2 and Runx3; however, the physiological role of Runx1 in chondrocyte differentiation remains unknown...
  41. pmc Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1): evidence for a new myc collaborating oncogene
    M Stewart
    Molecular Oncology Laboratory, Department of Veterinary Pathology, University of Glasgow, Bearsden, Glasgow G61 1QH, United Kingdom
    Proc Natl Acad Sci U S A 94:8646-51. 1997
    ..We now show that viral insertions at til-1 lead to transcriptional activation of PEBP2alphaA (CBFA1), a transcription factor related to the Drosophila segmentation gene product, Runt...
  42. ncbi Enhanced expression of Runx2/PEBP2alphaA/CBFA1/AML3 during fracture healing
    Hirohisa Kawahata
    Department of Pathology, Osaka University Medical School, Osaka, Japan
    J Orthop Sci 8:102-8. 2003
    ..change in the expression pattern of collagenous and noncollagenous bone matrix proteins in addition to Ets-1 and Runx2, major transcription factors of osteopontin, were examined and compared to that of osteopontin...
  43. ncbi Induction of osteoclast differentiation by Runx2 through receptor activator of nuclear factor-kappa B ligand (RANKL) and osteoprotegerin regulation and partial rescue of osteoclastogenesis in Runx2-/- mice by RANKL transgene
    Hirayuki Enomoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 278:23971-7. 2003
    ..b>Runx2-deficient (Runx2-/-) mice showed a complete lack of bone formation because of maturational arrest of osteoblasts ..
  44. pmc Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation
    David G Monroe
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    BMC Musculoskelet Disord 11:104. 2010
    ..transcription factors are involved in the establishment and maintenance of the osteoblastic phenotype, such as Runx2, osterix and Dlx5...
  45. ncbi AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization
    D Levanon
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Genomics 23:425-32. 1994
    cDNAs corresponding to three human runt domain containing genes, AML1, AML2, and AML3, were isolated and characterized...
  46. ncbi Runx2, a multifunctional transcription factor in skeletal development
    Toshihisa Komori
    Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Cell Biochem 87:1-8. 2002
    The identification of Runx2 (runt-related protein 2) function has greatly advanced the understanding of skeletal development over the last 5 years...
  47. pmc Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function
    Atsuko Shimoyama
    The Department of Molecular and Cellular Biochemistry, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Biol Cell 18:2411-8. 2007
    ..Ihh treatment or Gli2 overexpression also up-regulated the expression of Runx2, an essential transcription factor for osteoblastogenesis, and enhanced the transcriptional activity and ..
  48. pmc Co-stimulation of the bone-related Runx2 P1 promoter in mesenchymal cells by SP1 and ETS transcription factors at polymorphic purine-rich DNA sequences (Y-repeats)
    Ying Zhang
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Biol Chem 284:3125-35. 2009
    Transcriptional control of Runx2 gene expression through two alternative promoters (P1 and P2) is critical for the execution of its function as an osteogenic cell fate determining factor...
  49. pmc PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
    E Ogawa
    Department of Viral Oncology, Kyoto University, Japan
    Proc Natl Acad Sci U S A 90:6859-63. 1993
    ..The major species of PEBP2 alpha mRNA was expressed in T-cell lines but not in B-cell lines tested. Evidence indicated that PEBP2 functions as a transcriptional activator and is involved in regulation of T-cell-specific gene expression...
  50. ncbi Role of Runx genes in chondrocyte differentiation
    Sigmar Stricker
    Max Planck Institut fur Molekulare Genetik, Charite, Berlin, Germany
    Dev Biol 245:95-108. 2002
    Runx2/Cbfa1 plays a central role in skeletal development as demonstrated by the absence of osteoblasts/bone in mice with inactivated Runx2/Cbfa1 alleles...
  51. ncbi Core-binding factor beta interacts with Runx2 and is required for skeletal development
    Carolina A Yoshida
    Department of Molecular Medicine, Osaka University Medical School, 2 2 Yamada Oka Suita, Osaka 565 0871, Japan
    Nat Genet 32:633-8. 2002
    ..Both RUNX1 and CBFbeta are essential for hematopoiesis. Haploinsufficiency of another runt-related protein, RUNX2 (also called CBFA1), causes cleidocranial dysplasia in humans and is essential in skeletal development by ..
  52. ncbi Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2
    Daniel W Young
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Nature 445:442-6. 2007
    ..Runt-related transcription factors Runx1, Runx2 and Runx3 establish and maintain cell identity, and convey phenotypic information through successive cell ..
  53. ncbi Role of Msx2 as a promoting factor for Runx2 at the periodontal tension sides elicited by mechanical stress
    T Watanabe
    Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri, Japan
    Eur J Med Res 13:425-31. 2008
    Early changes of Runx2 and Msx2 expressions were examined by immunohistochemistry in mouse periodontal ligament exposed to mechanical stress. 8-week-old ddY mouse was used as experimental animal...
  54. ncbi The IIIc alternative of Fgfr2 is a positive regulator of bone formation
    Vereragavan P Eswarakumar
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot Israel
    Development 129:3783-93. 2002
    ..with decrease in the localized transcription of the osteoblast markers secreted phosphoprotein 1 (Spp1) and Runx2/Cbfa1. A decrease in the domain of transcription of the chondrocyte markers Ihh and PTHrP (Pthlh) corresponded with a ..
  55. pmc Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
    Carolina A Yoshida
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Genes Dev 18:952-63. 2004
    ..b>Runx2 is essential for osteoblast differentiation and is involved in chondrocyte maturation...
  56. ncbi Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification
    Lydia Koziel
    Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Dev Cell 6:801-13. 2004
    ..Finally, we propose that the development of exostoses in the human Hereditary Multiple Exostoses syndrome can be attributed to activation of Ihh signaling...
  57. pmc The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts
    Mario Galindo
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Biol Chem 280:20274-85. 2005
    The Runx2 (CBFA1/AML3/PEBP2alphaA) transcription factor promotes skeletal cell differentiation, but it also has a novel cell growth regulatory activity in osteoblasts...
  58. pmc Dominance of SOX9 function over RUNX2 during skeletogenesis
    Guang Zhou
    Howard Hughes Medical Institute and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:19004-9. 2006
    Mesenchymal stem cell-derived osteochondroprogenitors express two master transcription factors, SOX9 and RUNX2, during condensation of the skeletal anlagen...
  59. pmc Runx2 deficiency and defective subnuclear targeting bypass senescence to promote immortalization and tumorigenic potential
    Sayyed K Zaidi
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School and Cancer Center, 55 Lake Avenue North, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 104:19861-6. 2007
    The osteogenic Runt-related (Runx2) transcription factor negatively regulates proliferation and ribosomal gene expression in normal diploid osteoblasts, but is up-regulated in metastatic breast and prostate cancer cells...
  60. ncbi Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2
    E Zelzer
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mech Dev 106:97-106. 2001
    ..provide the first example of tissue specific loss of VEGF expression as a result of targeting a single gene, Cbfa1/Runx2. During endochondral bone formation, invasion of blood vessels into cartilage is associated with upregulation of ..
  61. ncbi Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts
    Min Jae Jeon
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul 110 744, Korea
    J Biol Chem 278:23270-7. 2003
    ..with the PPARgamma activator 15-deoxy-Delta12,14-prostaglandin J2 inhibited the mRNA expression of osteocalcin and Runx2, the latter of which is a key transcription factor in osteoblast differentiation...
  62. ncbi Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4
    Ritva Rice
    Developmental Biology Programme, Institute of Biotechnology, P O Box 56, 00014 University of Helsinki, Finland
    Dev Biol 262:75-87. 2003
    ..We therefore suggest that Foxc1 regulates BMP-mediated osteoprogenitor proliferation and that this regulation is required for the progression of osteogenesis beyond the initial condensations in calvarial bone development...
  63. pmc Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    Christa Maes
    Laboratory of Experimental Medicine and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium
    J Clin Invest 113:188-99. 2004
    ..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
  64. ncbi Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis
    Thomas Aberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 270:76-93. 2004
    b>Runx2 (Cbfa1) is a runt domain transcription factor that is essential for bone development and tooth morphogenesis...
  65. pmc A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis
    Veraragavan P Eswarakumar
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 101:12555-60. 2004
    ..They show enhanced Cbfa1/Runx2 expression without significant change in chondrocyte-specific Ihh, PTHrP, Sox9, Col2a, or Col10a gene ..
  66. pmc Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation
    Xizhi Guo
    Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA
    Genes Dev 18:2404-17. 2004
    ..Wnt4, Wnt14, and Wnt16 may play redundant roles in synovial joint induction by signaling through the beta-catenin-mediated canonical Wnt pathway...
  67. pmc Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene
    Mohammad Q Hassan
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655 0106, USA
    Mol Cell Biol 24:9248-61. 2004
    ..The transcriptionally repressed OC gene was occupied by Msx2 in proliferating osteoblasts, while Dlx3, Dlx5, and Runx2 were recruited postproliferatively to initiate transcription...
  68. pmc Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3
    Jong Seok Kang
    Department of Cell and Tissue Biology, Department of Anatomy, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0512, USA
    EMBO J 24:2543-55. 2005
    ..growth factor-beta (TGF-beta) inhibits osteoblast differentiation through inhibition of the function of Runx2 (Cbfa1) by Smad3. The mechanism through which TGF-beta/Smad3 inhibits Runx2 function has not been characterized...
  69. pmc Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts
    Hiroyuki Kaneki
    Department of Pathology and Laboratory Medicine, University of Rochester, School of Medicine and Dentistry, NY 14642, USA
    J Biol Chem 281:4326-33. 2006
    ..b>Runx2 is an osteoblast-specific transcription factor whose steady-state protein levels are regulated by proteasomal ..
  70. ncbi Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation
    Eiichi Hinoi
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    J Biol Chem 281:18015-24. 2006
    ..Stable overexpression of nrf2 significantly impaired Runx2 (runt-related transcription factor 2)-dependent stimulation of osteocalcin promoter activity and recruitment of ..
  71. ncbi SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
    Gergana Dobreva
    Max Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, 79108 Freiburg, Germany
    Cell 125:971-86. 2006
    ..Molecular analysis revealed that SATB2 directly interacts with and enhances the activity of both Runx2 and ATF4, transcription factors that regulate osteoblast differentiation...
  72. ncbi BMP-2 promotes differentiation of osteoblasts and chondroblasts in Runx2-deficient cell lines
    Tingjiao Liu
    Section of Oral Pathology, Department of Oral Restitution, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    J Cell Physiol 211:728-35. 2007
    ..underlying the differentiation of osteoblasts and chondroblasts, we established a clonal cell lines, RD-C6, from Runx2-deficient mouse embryos...
  73. ncbi Regulation of bone development and maintenance by Runx2
    Toshihisa Komori
    Department of Cell Biology, Unit of Basic Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8588, Japan
    Front Biosci 13:898-903. 2008
    b>Runx2 and Sp7/Osterix determine the osteoblast lineage from mesenchymal stem cells with canonical Wnt signaling...
  74. pmc Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation
    M J Jimenez
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Oviedo, 33006 Oviedo, Spain
    Mol Cell Biol 19:4431-42. 1999
    ..In this work, we have evaluated the possibility that Cbfa1 (core binding factor 1), a transcription factor playing a major role in the expression of osteoblastic specific ..
  75. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
    ..Together, the results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes...
  76. ncbi Multilineage differentiation of Cbfa1-deficient calvarial cells in vitro
    H Kobayashi
    Department of Molecular Medicine, Osaka University Medical School, 2 2 Yamada Oka Suita, Osaka, 565 0871, Japan
    Biochem Biophys Res Commun 273:630-6. 2000
    We characterized calvaria-derived cells of Cbfa1-deficient mice to determine their stages of differentiation...
  77. pmc Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    S Takeda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 15:467-81. 2001
    Chondrocyte hypertrophy is a mandatory step during endochondral ossification. Cbfa1-deficient mice lack hypertrophic chondrocytes in some skeletal elements, indicating that Cbfa1 may control hypertrophic chondrocyte differentiation...
  78. ncbi Analysis of type-I and type-II RUNX2 protein expression in osteoblasts
    S Sudhakar
    Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, University of Texas Health Science Center at San Antonio, San Antonio, TX 78284, USA
    Biochem Biophys Res Commun 286:74-9. 2001
    Runt-related transcription factor-2 (RUNX2) is expressed as two isoforms (type-I and type-II) differing only in their amino terminal sequences. The amino terminus of type-I contains MRIPV instead of MASNSLFSAVTPCQQSFFW in type-II...
  79. ncbi E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    Ming Zhao
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:27939-44. 2003
    ..signaling molecules Smad1 and -5 and the osteoblast-specific transcription factor core-binding factor alpha1 (Cbfa1)...
  80. ncbi Selective deficiency of the "bone-related" Runx2-II unexpectedly preserves osteoblast-mediated skeletogenesis
    Zhou Sheng Xiao
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Biol Chem 279:20307-13. 2004
    b>Runx2 (runt-related transcription factor 2) is a master regulator of skeletogenesis...
  81. pmc Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling
    Takashi Fujita
    Department of Pharmacology, Setsunan University, Hirakata, Japan
    J Cell Biol 166:85-95. 2004
    b>Runx2 and phosphatidylinositol 3-kinase (PI3K)-Akt signaling play important roles in osteoblast and chondrocyte differentiation. We investigated the relationship between Runx2 and PI3K-Akt signaling...
  82. ncbi Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development
    Nathan Smith
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Cell Physiol 203:133-43. 2005
    ..Initial studies have shown that both Runx1 and Runx2 are expressed in pre-chondrogenic mesenchyme of the developing embryo at E12.5...
  83. ncbi Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    Rick B Vega
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 119:555-66. 2004
    ..chondrocyte hypertrophy and endochondral bone formation by interacting with and inhibiting the activity of Runx2, a transcription factor necessary for chondrocyte hypertrophy...
  84. ncbi Runx2 regulates FGF2-induced Bmp2 expression during cranial bone development
    Kang Young Choi
    Department of Biochemistry, School of Dentistry and Skeletal Diseases Genome Research Center, Kyungpook National University, 101 Dong In dong, Jung Gu, Daegu, 700 422, Korea
    Dev Dyn 233:115-21. 2005
    ..Moreover, the disruption of the Runx2 gene completely eliminated the expression of Bmp2 and its downstream genes Dlx5 and Msx2 in the developing ..
  85. pmc Selective Runx2-II deficiency leads to low-turnover osteopenia in adult mice
    Zhousheng Xiao
    Internal Medicine The Kidney Institute, University of Kansas Medical Center, 6018 Wahl Hall East, Kansas City, 66160, USA
    Dev Biol 283:345-56. 2005
    b>Runx2 transcribes Runx2-II and Runx2-I isoforms with distinct N-termini...
  86. ncbi Cooperative interactions between activating transcription factor 4 and Runx2/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression
    Guozhi Xiao
    Department of Periodontics, Prevention, and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Biol Chem 280:30689-96. 2005
    ..ATF4 increased the levels of Ocn mRNA and mOG2 promoter activity in Runx2-containing osteoblasts but not in non-osteoblastic cells that lack detectable Runx2 protein...
  87. pmc Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation
    Hiroaki Kimura
    Department of Orthopaedics, Kyoto University, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 356:935-41. 2007
    ..Furthermore, TN-W was detectable in perichondrium/periosteum of Runx2-null and Osterix-null embryos, indicating that TN-W is expressed in preosteoblasts...
  88. ncbi The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the Cbfa1 transcription factor thereby increasing its activity
    Yi Luan
    Department of Orthopedic Surgery, New York University Medical Center, New York, New York 10003, USA
    J Biol Chem 282:16860-70. 2007
    ..the coordinated activity of numerous proteins including the transcription factor core-binding factor alpha1 (Cbfa1). Deregulation of Cbfa1 results in metabolic bone diseases including osteoporosis and osteopetrosis...
  89. pmc Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal
    Amjad Javed
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Biol Chem 283:8412-22. 2008
    ..pathways, bone morphogenetic protein (BMP)/transforming growth factor-beta (TGFbeta) and the transcription factor RUNX2, are required for bone formation in vivo...
  90. pmc Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo
    Meilin Wu
    Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Bone 44:528-36. 2009
    ..Zfp521 binds Runx2 and represses its transcriptional activity, and Runx2 dose-dependently rescues Zfp521's inhibition of osteoblast ..
  91. pmc T-box 3 negatively regulates osteoblast differentiation by inhibiting expression of osterix and runx2
    K E Govoni
    Musculoskeletal Disease Center, Jerry L Pettis VA Medical Center, Loma Linda, CA 92357, USA
    J Cell Biochem 106:482-90. 2009
    ..In addition, Tbx3 overexpression abolished increased osterix and runx2 expression observed during normal osteoblast differentiation, but the change in Msx1 and Msx2 expression over time ..
  92. pmc EphA4 as an effector of Twist1 in the guidance of osteogenic precursor cells during calvarial bone growth and in craniosynostosis
    Man Chun Ting
    Department of Biochemistry and Molecular Biology, Norris Cancer Hospital, University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9176, USA
    Development 136:855-64. 2009
    ..We suggest that the failure of this process in Twist1 and EphA4 mutants is the cause of craniosynostosis...
  93. pmc The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts
    Nadiya M Teplyuk
    Department of Cell Biology, Worcester, Massachusetts 01655 0106, USA
    Mol Endocrinol 23:849-61. 2009
    ..We show here that the osteogenic transcription factor Runx2 controls genes involved in sterol/steroid metabolism, including Cyp11a1, Cyp39a1, Cyp51, Lss, and Dhcr7 in murine ..
  94. pmc Early onset of craniosynostosis in an Apert mouse model reveals critical features of this pathology
    Greg Holmes
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 328:273-84. 2009
    ....
  95. pmc The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization
    Kyu Sang Joeng
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 136:4177-85. 2009
    ..These results therefore provide direct genetic evidence that Gli2 and Gli3 collectively mediate all major aspects of Ihh function during endochondral skeletal development...
  96. doi SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
    Development 137:901-11. 2010
    ..These findings imply that downregulation of Sox9 in the hypertrophic zone of the normal growth plate is essential for allowing vascular invasion, bone marrow formation and endochondral ossification...
  97. pmc Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression
    Tae Geon Kwon
    Department of Periodontics and Oral Medicine and Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    J Cell Biochem 112:3582-93. 2011
    ..On the other hand, deficiency of Runx2, a key osteogenic transcription factor, prevents vascular invasion of bone and VEGF expression...
  98. ncbi Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
    F Otto
    Imperial Cancer Research Fund, Lincoln s Inn Fields, London, United Kingdom
    Cell 89:765-71. 1997
    We have generated Cbfa1-deficient mice. Homozygous mutants die of respiratory failure shortly after birth. Analysis of their skeletons revealed an absence of osteoblasts and bone...
  99. pmc A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 13:1025-36. 1999
    ..b>Cbfa1, a transcriptional activator of osteoblast differentiation during embryonic development, is also expressed in ..
  100. pmc Subnuclear targeting of Runx/Cbfa/AML factors is essential for tissue-specific differentiation during embryonic development
    J Y Choi
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue, North Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 98:8650-5. 2001
    ..A unique targeting signal in the C terminus directs Runx factors to discrete foci within the nucleus. Using Runx2/CBFA1/AML3 and its essential role in osteogenesis as a model, we investigated the fundamental importance of fidelity of ..
  101. ncbi The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
    ..L-Sox5 and Sox6 are thus redundant, potent enhancers of chondroblast functions, thereby essential for endochondral skeleton formation...

Research Grants14

  1. Regulation of DMP1 Gene Expression in Bone and Tooth
    Shuo Chen; Fiscal Year: 2004
    ..These studies will therefore make an important contribution toward an overall understanding of the molecular basis of bone/tooth specific gene expression. ..
  2. Role of Cbfa1 Phosphorylation in Bone Metabolism
    Guozhi Xiao; Fiscal Year: 2003
    ..These studies will provide useful fundamental new knowledge regarding the molecular mechanism of bone formation and regeneration by bone growth factors and cytokines as well as by mechanical loading. ..
  3. THE ROLE OF UFD1 AND CDC45 IN NEURAL CREST DEVELOPMENT
    Vidu Garg; Fiscal Year: 2004
    ..The function of Cdc45 will be examined in vivo in chick embryos by retrovirally mediated alteration of gene expression. A yeast two hybrid assay will be utilized to determine if Ufdl, Cdc45, and Hira interact with one another. ..
  4. Osteoblastogenesis in Aortic Valve Calcification
    Nalini Rajamannan; Fiscal Year: 2006
    ..If hypercholesterolemia stimulates the development of calcification in the aortic valve then the use of medical therapy such as HMG CoA reductase medications may have a role in the medical therapy of calcific aortic stenosis. ..
  5. Identification of Histone Gene Regulatory Sequences
    Gary Stein; Fiscal Year: 2006
    ..These studies will elucidate parameters of growth control that mediate competency for proliferation and cell cycle progression. [unreadable] [unreadable]..
  6. THE PHYSIOLOGY OF IGFBP DEGRADING PROTEINASES IN BONE
    John Fowlkes; Fiscal Year: 2009
    ..abstract_text> ..
  7. Runx2 Controlled Adipocytic Differentiation in Aging Musculoskeleton
    Amjad Javed; Fiscal Year: 2009
    ..Null mutation of these factors results in lethality and loss of adipogenesis. Similarly, Runx2/Cbfa1 is an obligatory factor for osteoblast differentiation and bone formation during embryonic development...
  8. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010
    ..In addition, the proposed studies will, in the long-term, allow the development of novel therapeutic approaches for treatment of patients with dry eye syndromes. ..
  9. INTRANUCLEAR TRAFFICKING OF BONE TRANSCRIPTION FACTORS
    Gary Stein; Fiscal Year: 2001
    ....
  10. Role of sex steroids in female TIEG-null mouse bone loss
    John Hawse; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  11. Regulation of parietal bone differentiation
    Venkatesh Govindarajan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. THE ROLE OF p204 IN OSTEOGENESIS
    Chuanju Liu; Fiscal Year: 2007
    ..BMP-2-induced osteoblastic differentiation; and (3) p204 physically associates with core binding factor-alpha 1 (Cbfa1) and augments Cbfa1-dependent reporter gene activity...
  13. Physiological Role of ADAMTS-7B in Arthritis
    Chuanju Liu; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  14. RUNX2 AND PPAR-GAMMA IN CHONDROCYTE FUNCTION
    Masahiro Iwamoto; Fiscal Year: 2009
    ..b>Runx2 and PPARgamma are two transcription factors that have received a great deal of attention recently...