Rps6

Summary

Gene Symbol: Rps6
Description: ribosomal protein S6
Alias: S6R, 40S ribosomal protein S6, phosphoprotein NP33
Species: mouse

Top Publications

  1. pmc Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock
    Ruifeng Cao
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Mol Cell Neurosci 38:312-24. 2008
  2. pmc Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo
    Piraye Yurttas
    Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Development 135:2627-36. 2008
  3. pmc Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
    M Cecilia Ljungberg
    The Cain Foundation Laboratories, Texas Children s Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Dis Model Mech 2:389-98. 2009
  4. doi Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain
    Grigorios N Paliouras
    Department of Pathology and Cell Biology, Groupe de recherche sur le système nerveux central and Center of Excellence in Neuroscience of the Université de Montréal, Universite de Montreal, Montreal, Quebec, Canada, H3T 1J4
    J Neurosci 32:15012-26. 2012
  5. pmc Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
    Igor Ruvinsky
    Department of Biochemistry, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Genes Dev 19:2199-211. 2005
  6. doi CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex
    Javier Díaz-Alonso
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Instituto Universitario de Investigaciones Neuroquímicas IUIN, Department of Biochemistry and Molecular Biology I, Complutense University, Madrid 28040, Spain
    Cereb Cortex 25:2395-408. 2015
  7. pmc MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation
    Yingdee Unhavaithaya
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 284:6507-19. 2009
  8. doi Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
    C Chauvin
    1 INSERM, U845, Paris, France 2 Université Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, UMRS 845, Paris, France
    Oncogene 33:474-83. 2014
  9. pmc Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells
    Chohreh Partovian
    Angiogenesis Research Center, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Mol Cell 32:140-9. 2008
  10. pmc mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
    Won Jun Oh
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    EMBO J 29:3939-51. 2010

Research Grants

Scientific Experts

  • Adam L Hartman
  • S R Kimball
  • Z Tuhácková
  • S Welle
  • Oded Meyuhas
  • Jianquan Chen
  • Kelly A McGowan
  • Martina Barkic
  • Igor Ruvinsky
  • Markus A Ruegg
  • Linda Panic
  • Seonhee Kim
  • Michael J Gambello
  • Yuval Dor
  • Miri Stolovich-Rain
  • Iwan Jones
  • Mei Yang
  • Uk Yeol Moon
  • Gaspare La Rocca
  • Chunmei Wang
  • Javier Díaz-Alonso
  • Timothy D Calamaras
  • Sinisa Volarevic
  • Minhan Ka
  • Hao Hu
  • Fanxin Long
  • Aiping Ma
  • Vicki Plaks
  • C Chauvin
  • Edward Kim
  • Toshiyuki Yano
  • Deirdre A Nelson
  • Margit Rosner
  • Tobias Goller
  • Abed Khalaileh
  • Dimitri Cloëtta
  • Seo Hee Cho
  • Siobán B Keel
  • Zai Chang
  • Grigorios N Paliouras
  • F William Buaas
  • Sangyeul Han
  • Michael N Hall
  • Avital Swisa
  • James McKenna
  • O Meyuhas
  • Philippe A Hasgall
  • Avigail Dreazen
  • Susanna M I Goorden
  • Charbel Darido
  • M Rosner
  • Qiuting Feng
  • Pier Paolo Pandolfi
  • Andrew C Hsieh
  • Kathryn E Marshall
  • V Hudon
  • Won Jun Oh
  • Christopher Y Park
  • Gregory S Barsh
  • Yingdee Unhavaithaya
  • Zvi Granot
  • Yukiko Hasumi
  • Ilona Patursky-Polischuk
  • M Cecilia Ljungberg
  • Joby J Westmoreland
  • Judith Kasir
  • Robert J Salmond
  • Stefano Fumagalli
  • Kristen Pollizzi
  • Ruifeng Cao
  • Chohreh Partovian
  • Y J Jeon
  • Piraye Yurttas
  • Kevin Kyungsuk Park
  • Sanda Tamarut
  • Kristina Grabusic
  • Omar Hernandez
  • David J Kwiatkowski
  • Balazs Hegedus
  • Yusong Gong
  • Bangyan L Stiles
  • Miljana Uzelac
  • Sanda Sulic
  • Sohail F Tavazoie
  • O Jameel Shah
  • Martina Niksic
  • Christina S Leslie
  • Yasuo Ido
  • Eric G Moss
  • Yan Liu

Detail Information

Publications75

  1. pmc Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock
    Ruifeng Cao
    Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA
    Mol Cell Neurosci 38:312-24. 2008
    ..Together these data identify a light-responsive mTOR cascade in the SCN, and thus, raise the possibility that inducible translation contributes to the clock entrainment process...
  2. pmc Role for PADI6 and the cytoplasmic lattices in ribosomal storage in oocytes and translational control in the early mouse embryo
    Piraye Yurttas
    Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Development 135:2627-36. 2008
    ..These results suggest that, in mammals, ribosomal components are stored in the oocyte CPLs and are required for protein translation during early development...
  3. pmc Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia
    M Cecilia Ljungberg
    The Cain Foundation Laboratories, Texas Children s Hospital, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Dis Model Mech 2:389-98. 2009
    ..These findings support the possibility that this drug may be developed as a novel antiepileptic treatment for patients with cortical dysplasia and similar disorders...
  4. doi Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain
    Grigorios N Paliouras
    Department of Pathology and Cell Biology, Groupe de recherche sur le système nerveux central and Center of Excellence in Neuroscience of the Université de Montréal, Universite de Montreal, Montreal, Quebec, Canada, H3T 1J4
    J Neurosci 32:15012-26. 2012
    ..These findings establish fundamental links between mTOR signaling, proliferation, and aging-associated quiescence in the adult forebrain NSC niche...
  5. pmc Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
    Igor Ruvinsky
    Department of Biochemistry, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Genes Dev 19:2199-211. 2005
    ..To directly address this issue, we have established viable and fertile knock-in mice, whose rpS6 contains alanine substitutions at all five phosphorylatable serine residues (rpS6(P-/-))...
  6. doi CB1 Cannabinoid Receptor-Dependent Activation of mTORC1/Pax6 Signaling Drives Tbr2 Expression and Basal Progenitor Expansion in the Developing Mouse Cortex
    Javier Díaz-Alonso
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Instituto Universitario de Investigaciones Neuroquímicas IUIN, Department of Biochemistry and Molecular Biology I, Complutense University, Madrid 28040, Spain
    Cereb Cortex 25:2395-408. 2015
    ....
  7. pmc MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation
    Yingdee Unhavaithaya
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 284:6507-19. 2009
    ..These observations indicate that MILI may positively regulate translation and that such regulation is required for germ line stem cell self-renewal...
  8. doi Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
    C Chauvin
    1 INSERM, U845, Paris, France 2 Université Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, UMRS 845, Paris, France
    Oncogene 33:474-83. 2014
    ..S6Ks phosphorylate ribosomal protein S6 (rpS6) and additional proteins involved in the translational machinery, although the functional roles of these ..
  9. pmc Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cells
    Chohreh Partovian
    Angiogenesis Research Center, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Mol Cell 32:140-9. 2008
    ..Thus, S4-dependent targeting of PKCalpha to the plasma membrane is required for recruitment of mTORC2 components to the rafts and Akt activation...
  10. pmc mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
    Won Jun Oh
    Department of Physiology and Biophysics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    EMBO J 29:3939-51. 2010
    ..Thus, mTORC2 can function cotranslationally by phosphorylating residues in nascent chains that are critical to attain proper conformation. Our findings reveal that mTOR links protein production with quality control...
  11. pmc Quantitative single cell analysis of cell population dynamics during submandibular salivary gland development and differentiation
    Deirdre A Nelson
    Department of Biological Sciences, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA
    Biol Open 2:439-47. 2013
    ..The data suggest that there are temporally and spatially discreet progenitor populations that contribute to salivary gland development and homeostasis. ..
  12. doi Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality
    Aiping Ma
    Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China
    Hum Mol Genet 23:693-705. 2014
    ..We postulated that disruption of normal angiogenic pathways through hyperactive mTOR signaling maybe the mechanism that lead to deranged vascular pathogenesis in the tuberous sclerosis complex. ..
  13. pmc WNT7B promotes bone formation in part through mTORC1
    Jianquan Chen
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 10:e1004145. 2014
    ..Genetic disruption of mTORC1 signaling by deleting Raptor in the osteoblast lineage alleviated the WNT7B-induced high-bone-mass phenotype. Thus, WNT7B promotes bone formation in part through mTORC1 activation. ..
  14. pmc Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling
    Toshiyuki Yano
    From the Department of Pathology T Y, C S and Division of Cardiology, Department of Medicine M F, Johns Hopkins University, Baltimore, MD Proteomics Core A A and Systems Biology Center E M, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD and Departments of Cardiovascular, Renal, and Metabolic Medicine T Y, A K, T M and Pharmacology A K, Sapporo Medical University, Sapporo, Japan
    Circ Res 114:1268-80. 2014
    ..There is tight coupling between Akt activation and suppression of cell death. Full Akt activation requires mammalian target of rapamycin complex 2 (mTORC2), but the regulation of mTORC2 is unclear...
  15. doi Blastocyst implantation failure relates to impaired translational machinery gene expression
    Vicki Plaks
    Departments of Biological RegulationPhysics of Complex SystemsThe Weizmann Institute of Science, Rehovot 76100, IsraelInstitute of AnatomyUniversity Hospital Duisburg Essen, Essen, GermanyThe Sheba Cancer Research CenterSheba Medical Center, Tel Hashomer, Israel
    Reproduction 148:87-98. 2014
    ..This information could be implicated to diagnosis and treatment of infertility, particularly to IVF. ..
  16. pmc 4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice
    Chunmei Wang
    Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA
    Hepatology 61:200-13. 2015
    ..mTORC1 functions by regulating p70S6K/ribosomal protein S6 (RPS6) and eukaryotic translation initiation factor 4E-binding protein 1/ eukaryotic translation initiation factor 4E (..
  17. pmc A novel mouse model of tuberous sclerosis complex (TSC): eye-specific Tsc1-ablation disrupts visual-pathway development
    Iwan Jones
    Umeå Center for Molecular Medicine UCMM, Umea University, Umea 901 87, Sweden
    Dis Model Mech 8:1517-29. 2015
    ....
  18. pmc Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex
    Uk Yeol Moon
    Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Cell Rep 12:965-78. 2015
    ..Thus, disrupted Reelin-Dab1 signaling is critically involved in the neuronal migration defects of TSC. ..
  19. pmc Lin28 promotes the proliferative capacity of neural progenitor cells in brain development
    Mei Yang
    Department of Genetics, Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA
    Development 142:1616-27. 2015
    ..Thus, Lin28a and Lin28b have overlapping functions in temporally regulating NPC proliferation during early brain development. ..
  20. pmc The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling
    Timothy D Calamaras
    Myocardial Biology Unit, Cardiovascular Medicine, and Diabetes and Metabolism Research Unit, Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Free Radic Biol Med 82:137-46. 2015
    ..HNE inhibited the downstream kinase AMPK, increased hypertrophic mTOR-p70S6K-RPS6 signaling, and stimulated protein synthesis by 27.1 ± 3.5%...
  21. pmc Mutations in PTRH2 cause novel infantile-onset multisystem disease with intellectual disability, microcephaly, progressive ataxia, and muscle weakness
    Hao Hu
    Max Planck Institute for Molecular Genetics Berlin, Germany
    Ann Clin Transl Neurol 1:1024-35. 2014
    ..To identify the cause of a so-far unreported phenotype of infantile-onset multisystem neurologic, endocrine, and pancreatic disease (IMNEPD)...
  22. pmc In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA
    Gaspare La Rocca
    Cancer Biology and Genetics Program
    Proc Natl Acad Sci U S A 112:767-72. 2015
    ..Overall, data presented here demonstrate that microRNA-mediated target repression in nontransformed cells depends not only on abundance of specific microRNAs, but also on regulation of RISC assembly by intracellular signaling. ..
  23. pmc Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1
    Edward Kim
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, United States
    elife 3:. 2014
    ....
  24. pmc mTOR regulates brain morphogenesis by mediating GSK3 signaling
    Minhan Ka
    Developmental Neuroscience, Munroe Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Development 141:4076-86. 2014
    ..Our findings reveal that the interaction between mTOR and GSK3 signaling plays an essential role in dynamic homeostasis of neural progenitors during brain development...
  25. pmc mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis
    Jianquan Chen
    Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 141:2848-54. 2014
    ..Metabolic labeling reveals a notable deficit in the rate of protein synthesis in Raptor-deficient chondrocytes. Thus, mTORC1 signaling controls limb skeletal growth through stimulation of protein synthesis in chondrocytes. ..
  26. doi MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells
    Robert J Salmond
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 183:7388-97. 2009
    Ribosomal protein S6 (rpS6) is a key component of the translational machinery in eukaryotic cells and is essential for ribosome biogenesis...
  27. doi Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis
    Charbel Darido
    Department of Medicine, Monash University Central Clinical School, Prahran, Victoria 3181, Australia
    Cancer Cell 20:635-48. 2011
    ..Our data define the GRHL3-PTEN axis as a critical tumor suppressor pathway in SCC...
  28. pmc Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis
    Siobán B Keel
    Department of Medicine, University of Washington, Seattle, WA 98195 7710, USA
    Exp Hematol 40:290-4. 2012
    ..The mice have an erythroid phenotype similar to both Diamond-Blackfan anemia and the 5q- syndrome and lenalidomide therapy improves their anemia...
  29. pmc The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains
    Sangyeul Han
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    J Biol Chem 287:30063-72. 2012
    ..The ubiquitin ligase complex containing Pam-Fbxo45 likely targets additional synaptic and axonal proteins, which may explain the overlapping neurodevelopmental defects observed in Phr1 and Fbxo45 deficiency...
  30. doi Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis
    Dimitri Cloëtta
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Neurosci 33:7799-810. 2013
    ..Together, our results show that postnatal survival, overall brain growth, and specific aspects of brain development critically depend on mTORC1 function...
  31. pmc The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice
    Adam L Hartman
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e45156. 2012
    ..To gain insights into how rapamycin suppresses seizures, we investigated the anticonvulsant activity of rapamycin using acute seizure tests in mice...
  32. pmc In vivo evidence for the crucial role of SF1 in steroid-producing cells of the testis, ovary and adrenal gland
    F William Buaas
    Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Development 139:4561-70. 2012
    ..This study is the first to show the in vivo requirements of SF1 in steroidogenesis and provides novel data on the cellular consequences of the loss of this protein specifically within steroid-producing cells...
  33. doi Phosphorylation of nuclear and cytoplasmic pools of ribosomal protein S6 during cell cycle progression
    Margit Rosner
    Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090, Vienna, Austria
    Amino Acids 44:1233-40. 2013
    Of all known ribosomal proteins, the 40S ribosomal protein S6 is by far the most extensively studied. Still, little is known about some basic aspects of S6 regulation including its cell cycle-related expression and localization...
  34. doi Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer
    Abed Khalaileh
    Department of Biochemistry and Molecular Biology, The Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Cancer Res 73:1811-20. 2013
    ..Here, we focus on ribosomal protein S6 (rpS6), an mTOR effector not implicated previously in cancer...
  35. pmc Atad3 function is essential for early post-implantation development in the mouse
    Tobias Goller
    LIMES Institute, Program Unit Molecular Cell and Immune Biology, University of Bonn, Bonn, Germany
    PLoS ONE 8:e54799. 2013
    ..At the biochemical level, we report here that ATAD3 is present in five native mitochondrial protein complexes of different sizes, indicating complex roles of the protein in mitochondrial architecture and function...
  36. pmc Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome
    Kelly A McGowan
    Departments of Genetics, Stanford University, Stanford, CA, USA
    Blood 118:3622-33. 2011
    ....
  37. pmc The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation
    Philippe A Hasgall
    Institute of Physiology and Zurich Center for Integrative Human Physiology ZIHP, University of Zurich UZH, Zurich, Switzerland
    PLoS ONE 6:e22107. 2011
    ..Importantly, downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6...
  38. pmc Rheb is essential for murine development
    Susanna M I Goorden
    Department of Neuroscience, Erasmus MC University Medical Center, P O Box 2040, 3000 CA Rotterdam, Netherlands
    Mol Cell Biol 31:1672-8. 2011
    ..Rheb heterozygosity extended the life span of tuberous sclerosis complex 1-deficient (Tsc1(-/-)) embryos, indicating that there is a genetic interaction between the Tsc1 and Rheb genes in mouse...
  39. pmc Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
    Andrew C Hsieh
    School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA
    Cancer Cell 17:249-61. 2010
    ..While phosphorylation of rpS6 is dispensable for cancer formation, 4EBP-eIF4E exerts significant control over cap-dependent translation, cell ..
  40. pmc Dynamic Lkb1-TORC1 signaling as a possible mechanism for regulating the endoderm-intestine transition
    Kathryn E Marshall
    Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Dev Dyn 239:3000-12. 2010
    ..These data suggest that programmed localization of Lkb1 could represent a novel mechanism for regulating the EIT during intestinal development in vertebrates...
  41. ncbi IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells
    Zdena Tuhácková
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 166 37 Prague 6, Czech Republic
    Int J Mol Med 13:601-5. 2004
    ..Here we demonstrate that the phosphorylation of 40S ribosomal protein S6, a physiological substrate p70 S6 kinase, was highly increased by growth-stimulation of the cytolytic T ..
  42. doi Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms
    Balazs Hegedus
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Stem Cell 1:443-57. 2007
    ..Together, these findings demonstrate that neurofibromin is required for normal glial and neuronal development involving separable Ras-dependent and cAMP-dependent mechanisms...
  43. doi Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling
    Y J Jeon
    School of Biological Science Bio Max Institute, Seoul National University, Seoul, Korea
    Oncogene 27:4344-52. 2008
    ..performed a functional genetic screening and rescued TRAIL-resistant Jurkat clones harboring ribosomal protein S6 (rpS6) cDNA in anti-sense frame...
  44. ncbi The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms
    Yusong Gong
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:31019-27. 2007
    ..Dissecting the contributions of these individual pathways to leptin action will be important for our ultimate understanding of the processes that regulate energy balance in vivo...
  45. ncbi Generation of a conditional disruption of the Tsc2 gene
    Omar Hernandez
    Department of Pediatrics, Division of Medical Genetics, University of Texas Health Science Center, Houston 77030, USA
    Genesis 45:101-6. 2007
    ..Using this Tsc2(flox) allele we have generated a null allele using Cre recombination. This allele will be useful in investigating TSC pathology with appropriate cell and organ specific Cre-transgenic mice...
  46. pmc Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation
    Linda Panic
    Department of Molecular Medicine and Biotechnology, School of Medicine, University of Rijeka, Brace Branchetta 20, 51000, Rijeka, Croatia
    Mol Cell Biol 26:8880-91. 2006
    ..Thus, a p53-dependent checkpoint is activated during gastrulation in response to ribosome insufficiency to prevent improper execution of the developmental program...
  47. pmc Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes
    Bangyan L Stiles
    Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA
    Mol Cell Biol 26:2772-81. 2006
    ..Our data demonstrate that PTEN loss in beta cells is not tumorigenic but beneficial. This suggests that modulating the PTEN-controlled signaling pathway is a potential approach for beta-cell protection and regeneration therapies...
  48. pmc Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response
    Sanda Sulic
    Department of Molecular Medicine and Biotechnology, School of Medicine, University of Rijeka, Croatia
    Genes Dev 19:3070-82. 2005
    ..the effect of impaired ribosome functions in vivo, we conditionally deleted one or two alleles of the 40S ribosomal protein S6 gene in T cells in the mouse...
  49. ncbi Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
    Sohail F Tavazoie
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 8:1727-34. 2005
    ..Thus, the TSC pathway regulates growth and synapse function in neurons, and perturbations of neuronal structure and function are likely to contribute to the pathogenesis of the neurological symptoms of TSC...
  50. ncbi Critical role of T-loop and H-motif phosphorylation in the regulation of S6 kinase 1 by the tuberous sclerosis complex
    O Jameel Shah
    Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 279:20816-23. 2004
    ..These results also highlight the importance of dual control of T-loop and H-motif phosphorylation of S6K1 by the Tsc1-Tsc2 complex...
  51. ncbi The Wilms' tumour protein (WT1) shuttles between nucleus and cytoplasm and is present in functional polysomes
    Martina Niksic
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Hum Mol Genet 13:463-71. 2004
    ..Interestingly, despite the functional differences between two of the WT1 isoforms (+/-KTS) within the nucleus, both isoforms share the shuttling property and are found in translating polysomes...
  52. ncbi Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes
    Scot R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Cell Physiol 284:C273-84. 2003
    ..Finally, we also show that stress granules contain many, if not all, of the components of the 48S preinitiation complex, but not 60S ribosomal subunits, suggesting that they represent stalled translation initiation complexes...
  53. ncbi Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6
    S Volarevic
    Friedrich Miescher Institute, Maulbeerstrasse 66, CH 4058, Basel, Switzerland
    Science 288:2045-7. 2000
    ..To test this possibility, we conditionally deleted the gene encoding 40S ribosomal protein S6 in the liver of adult mice...
  54. ncbi Structural characterization of the mouse ribosomal protein S6-encoding gene
    I Pata
    Institute of Molecular and Cell Biology, Tartu University, Estonian Biocentre, Estonia
    Gene 175:241-5. 1996
    ..7 kb in length, and is composed of five exons. The intron positions of the mouse S6 (Rps6) coincide exactly to those of the homologous human S6 (RPS6), but the last intron present in the human is absent in ..
  55. ncbi The mammalian RPS6 gene, homolog of the Drosophila air8 tumor suppressor gene: is it an oncosuppressor gene?
    F Lecomte
    Universite Libre de Bruxelles, Departement de Biologie Moleculaire, Rhode Saint Genese, Belgium
    Somat Cell Mol Genet 21:443-50. 1995
    ..We assigned the rat Rps6 gene to chromosome 5q22-33...
  56. ncbi Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum
    H R Bandi
    Friedrich Miescher Institute, Basel, Switzerland
    J Biol Chem 268:4530-3. 1993
    ..The results show that the phosphorylated peptide extends from Arg231 to Lys249 and that the sites of phosphorylation in vivo are Ser235, Ser240, Ser244, and Ser247...
  57. pmc Complete sequence of mouse S6 ribosomal protein
    J L Lalanne
    Nucleic Acids Res 15:4990. 1987
  58. pmc A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles
    Kristen Pollizzi
    Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 18:2378-87. 2009
    ..Tsc2-del3 mice also serve as a model for hypomorphic TSC2 missense mutations reported in TSC patients...
  59. pmc PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development
    Qiuting Feng
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Mol Cell Biol 30:3711-21. 2010
    ..Taken together, these results have revealed an essential role of PDK1 in cardiovascular development through activation of Akt and Snail...
  60. pmc The apical complex couples cell fate and cell survival to cerebral cortical development
    Seonhee Kim
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Division of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Neuron 66:69-84. 2010
    ..These data highlight unexpected roles of the apical complex protein Pals1 in cell survival through interactions with mTOR signaling...
  61. ncbi Mitogen-activated 70K S6 kinase. Identification of in vitro 40 S ribosomal S6 phosphorylation sites
    S Ferrari
    Friedrich Miescher Institute, Basel, Switzerland
    J Biol Chem 266:22770-5. 1991
    ..The low level of phosphorylation of the fifth site in vitro is discussed with regard to known results and to a potential three-dimensional model for the carboxyl terminus of S6...
  62. pmc Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2
    Yukiko Hasumi
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:18722-7. 2009
    ....
  63. doi Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin
    V Hudon
    Goodman Cancer Centre, McGill University, Room 707A, McIntyre Building, 3655 Sir William Osler Promenade, Montreal, Quebec, Canada H3G1Y6
    J Med Genet 47:182-9. 2010
    ..The molecular function of FLCN is still largely unknown; opposite and conflicting evidence of the role of FLCN in mammalian target of rapamycin signalling/phosphorylated ribosomal protein S6 (p-S6) activation had recently been reported...
  64. pmc LKB1 regulates pancreatic beta cell size, polarity, and function
    Zvi Granot
    Department of Developmental Biology and Cancer Research and Molecular Biology, The Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cell Metab 10:296-308. 2009
    ..Insulin secretion and content are restricted by LKB1, at least in part, via AMPK. These results expose a molecular mechanism, orchestrated by LKB1, for the coordinated maintenance of beta cell size, form, and function...
  65. pmc Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells
    Joby J Westmoreland
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 334:285-98. 2009
    ....
  66. pmc Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit
    Igor Ruvinsky
    Department of Biochemistry and Molecular Biology, IMRIC, Hebrew University Hadassah Medical School, Jerusalem, Israel
    PLoS ONE 4:e5618. 2009
    ..protein S6 cannot be phosphorylated due to replacement of all five phosphorylatable serine residues by alanines (rpS6(P-/-)), are viable and fertile...
  67. doi Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236
    M Rosner
    Institute of Medical Genetics, Medical University of Vienna, Währinger Strasse 10, 1090, Vienna, Austria
    Amino Acids 40:595-600. 2011
    ..Our findings provide new insights into the regulation of S6 phosphorylation and S6 protein localization in mammalian cells...
  68. pmc Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction
    Stefano Fumagalli
    Department of Cancer and Cell Biology, Genome Research Institute, University of Cincinnati, 2180 East Galbraith Road, Cincinnati, Ohio 45237, USA
    Nat Cell Biol 11:501-8. 2009
    ..Previously, we demonstrated that deletion of the 40S rpS6 gene in mouse liver prevents hepatocytes from re-entering the cell cycle after partial hepatectomy...
  69. pmc The p53 tumor suppressor causes congenital malformations in Rpl24-deficient mice and promotes their survival
    Martina Barkic
    Department of Molecular Medicine and Biotechnology, School of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia
    Mol Cell Biol 29:2489-504. 2009
    ..Our results imply that activation of a p53-dependent checkpoint mechanism in response to various ribosomal protein deficiencies might also play a role in the pathogenesis of congenital malformations in humans...
  70. pmc Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice
    Stephen Welle
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Physiol Endocrinol Metab 296:E567-72. 2009
    ..JA16 increased phosphorylation of p70 S6 kinase (S6K) and ribosomal protein S6 (rpS6) 1.9-fold (P < 0.05)...
  71. pmc The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner
    Ilona Patursky-Polischuk
    Department of Biochemistry, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Mol Cell Biol 29:640-9. 2009
    ..This conclusion is further supported by the observation that raptor knockout renders the translation of TOP mRNAs rapamycin hypersensitive...
  72. pmc Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
    Kevin Kyungsuk Park
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 322:963-6. 2008
    ..Thus, our results suggest the manipulation of intrinsic growth control pathways as a therapeutic approach to promote axon regeneration after CNS injury...
  73. pmc Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects
    Kelly A McGowan
    Department of Genetics, Division of Radiation and CancerBiology, Stanford University, Stanford, California 94305, USA
    Nat Genet 40:963-70. 2008
    ....

Research Grants3

  1. CHANGES IN GENE EXPRESSION IN SENESCENT MUSCLE
    Stephen Welle; Fiscal Year: 2003
    ..abstract_text> ..
  2. Muscle protein synthesis and gene expression in myostatin-deficient mice
    Stephen L Welle; Fiscal Year: 2010
    ..Knowledge of the physiological and molecular effects of reducing myostatin activity in mature muscle will reveal potential benefits and limitations of anti-myostatin therapy. ..
  3. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    Scot R Kimball; Fiscal Year: 2010
    ....