Rorc

Summary

Gene Symbol: Rorc
Description: RAR-related orphan receptor gamma
Alias: Nr1f3, RORgamma, TOR, Thor, nuclear receptor ROR-gamma, RAR-related orphan receptor C, nuclear receptor RZR-gamma, nuclear receptor subfamily 1 group F member 3, retinoid-related orphan receptor-gamma, thymus orphan receptor
Species: mouse

Top Publications

  1. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
  2. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
  3. doi Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
    Kenji Ichiyama
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 283:17003-8. 2008
  4. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
  5. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
  6. pmc Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
    Michael H Shaw
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 209:251-8. 2012
  7. doi Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression
    Fanny Chalmin
    INSERM, U866, 21000 Dijon, France
    Immunity 36:362-73. 2012
  8. doi Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    Carmelo Luci
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, 13288 Marseille, France
    Nat Immunol 10:75-82. 2009
  9. pmc Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands
    Yongjun Wang
    Scripps Research Institute, Jupiter, Florida 33458, USA
    J Biol Chem 285:5013-25. 2010
  10. pmc Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis
    Martin Angers
    Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem J 416:347-55. 2008

Research Grants

Scientific Experts

  • Elke Eggenhofer
  • ROZA INSAFETDINOVNA NURIEVA
  • Xiaohuan Guo
  • Ahmed Nadeem
  • Kensuke Shibata
  • Ferry Cornelissen
  • Yuanzheng Yang
  • Magdalena Huber
  • STEPHEN LLOYD TILLEY
  • Z Tuhácková
  • You Wen He
  • Gerard Eberl
  • Cedric Vonarbourg
  • Mark H Kaplan
  • Stephane Chappaz
  • Anton M Jetten
  • Hong Soon Kang
  • Dan R Littman
  • Yukimasa Takeda
  • Ivaylo I Ivanov
  • Chen Dong
  • Yeonseok Chung
  • Xuexian O Yang
  • Liang Zhou
  • Andreas Diefenbach
  • Shinichiro Sawa
  • Matthias Lochner
  • Stephanie L Sanos
  • Gustavo J Martinez
  • Daniela Finke
  • Martin Angers
  • Masayuki Tsuji
  • Stephanie S Watowich
  • Christoph S N Klose
  • Thomas Hoyler
  • Jacob S Lee
  • Elina A Kiss
  • Abbas Hawwari
  • Arthur Mortha
  • Sidonia Fagarasan
  • Burkhard Becher
  • Shinya Tanaka
  • Naoko Satoh-Takayama
  • Sandrine Schmutz
  • Li Ma
  • Qiang Tian
  • Huimin Xie
  • Bruno Silva-Santos
  • Michael S Krangel
  • Giuliana Magri
  • Takeshi Egawa
  • P You
  • Anja Fuchs
  • Sarah Nuñez
  • André Gladiator
  • Satoshi Ano
  • Laura M Degraff
  • Maho Suzukawa
  • Marie Cherrier
  • Fanny Chalmin
  • A Medvedev
  • Lequn Li
  • Ju Qiu
  • Marina Cella
  • Michael H Shaw
  • Rodney D Newberry
  • Marco Colonna
  • Maria Ciofani
  • Timotheus Y F Halim
  • Yohei Kawai
  • Laura Codarri
  • Iwona Powolny-Budnicka
  • Ruiqing Wang
  • Bettina Meissburger
  • Guoliang Cui
  • Tao Xu
  • Tomomi Yamashita
  • Eric V Dang
  • Masashi Tachibana
  • Yang Xin Fu
  • Susumu Nakae
  • Takayuki Yoshimoto
  • Kazuyo Moro
  • Parinaz Aliahmad
  • Tetsuji Naka
  • Maya Eisenring
  • Daniel Cua
  • Yugang Wang
  • Sofia Buonocore
  • Jacqueline D Shields

Detail Information

Publications112 found, 100 shown here

  1. pmc T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 28:29-39. 2008
    ..Therefore, Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma...
  2. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..transforming growth factor-beta (TGF-beta), but depends on distinct transcription factors: RORgammat (encoded by Rorc(gammat)) for T(H)17 cells and Foxp3 for T(reg) cells...
  3. doi Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
    Kenji Ichiyama
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 283:17003-8. 2008
    ..We propose that induction of Foxp3 is the mechanism for the suppression of Th17 and polarization into inducible Treg...
  4. pmc Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    Xuexian O Yang
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 29:44-56. 2008
    ..STAT3 regulated Foxp3 downregulation, whereas STAT3, RORgamma, and ROR* were required for IL-17 expression in Treg cells...
  5. pmc Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..did not require transforming growth factor beta (TGF-beta) or Th17-specific orphan nuclear receptors RORalpha and RORgamma in vivo...
  6. pmc Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
    Michael H Shaw
    Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 209:251-8. 2012
    ..Thus, commensal-induced IL-1β production is a critical step for sT(H)17 differentiation in the intestine, which may have therapeutic implications for T(H)17-mediated pathologies...
  7. doi Stat3 and Gfi-1 transcription factors control Th17 cell immunosuppressive activity via the regulation of ectonucleotidase expression
    Fanny Chalmin
    INSERM, U866, 21000 Dijon, France
    Immunity 36:362-73. 2012
    ..Finally, adoptive transfer of Th17 cells induced by TGF-β and IL-6 promoted tumor growth in a CD39-dependent manner. Thus, ectonucleotidase expression supports the immunosuppressive fate of Th17 cells in cancer...
  8. doi Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    Carmelo Luci
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Institut National de la Sante et de la Recherche Medicale, U631, 13288 Marseille, France
    Nat Immunol 10:75-82. 2009
    ..Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair...
  9. pmc Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands
    Yongjun Wang
    Scripps Research Institute, Jupiter, Florida 33458, USA
    J Biol Chem 285:5013-25. 2010
    The retinoic acid receptor-related orphan receptors alpha and gamma (RORalpha (NR1F1) and RORgamma (NR1F3)) are orphan nuclear receptors and perform critical roles in regulation of development, metabolism, and immune function...
  10. pmc Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis
    Martin Angers
    Cell Biology Section, LRB, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem J 416:347-55. 2008
    ..The observed induction of Mfsd2a expression in cultured BAT cells by dibutyryl-cAMP is in agreement with this conclusion. The present study suggests that Mfsd2a plays a role in adaptive thermogenesis...
  11. ncbi Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element
    A Medvedev
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Gene 181:199-206. 1996
    ..ROR alpha 1 and ROR gamma inhibit the transactivation induced by GAL4(DBD)-ROR gamma in fibroblast D1 cells suggesting that these receptors compete for binding to the same coactivators...
  12. ncbi Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 22:705-16. 2005
    ..Our results indicate that even though CD1d binding DP thymocytes have yet to be observed, Valpha14-Jalpha18 rearrangement in these cells is required for development of iNKT cells...
  13. ncbi Induction of the nuclear orphan receptor RORgamma during adipocyte differentiation of D1 and 3T3-L1 cells
    S Austin
    Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Cell Growth Differ 9:267-76. 1998
    ..RORalpha and RORgamma mRNA were upregulated during adipocyte differentiation in preadipocyte D1 and 3T3-L1 cells, whereas RORbeta mRNA ..
  14. pmc RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells
    Y W He
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle 98195, USA
    Immunity 9:797-806. 1998
    We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes...
  15. ncbi RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORgamma / TOR, is up-regulated by signaling through the pre-T cell receptor and binds to the TEA promoter
    I Villey
    Développement Normal et Pathologique du Système Immunitaire INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Eur J Immunol 29:4072-80. 1999
    ..RORgammaT cDNA clone was isolated from a thymus library using a probe corresponding to the DNA-binding domain of RORgamma / TOR...
  16. ncbi Requirement for RORgamma in thymocyte survival and lymphoid organ development
    Z Sun
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA
    Science 288:2369-73. 2000
    ..Here, we show that mice lacking the orphan nuclear hormone receptor RORgamma lose thymic expression of the anti-apoptotic factor Bcl-xL...
  17. pmc Retinoid-related orphan receptor gamma (RORgamma) is essential for lymphoid organogenesis and controls apoptosis during thymopoiesis
    S Kurebayashi
    Cell Biology Section, Laboratory of Pulmonary Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 97:10132-7. 2000
    To identify the physiological functions of the retinoid-related orphan receptor gamma (RORgamma), a member of the nuclear receptor superfamily, mice deficient in RORgamma function were generated by targeted disruption...
  18. ncbi Cutting edge: organogenesis of nasal-associated lymphoid tissue (NALT) occurs independently of lymphotoxin-alpha (LT alpha) and retinoic acid receptor-related orphan receptor-gamma, but the organization of NALT is LT alpha dependent
    Allen Harmsen
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    J Immunol 168:986-90. 2002
    ..These results demonstrate that the organogenesis of NALT occurs through unique mechanisms...
  19. ncbi An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 5:64-73. 2004
    ..We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells...
  20. ncbi Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells
    Gerard Eberl
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Science 305:248-51. 2004
    ..Our results suggest that intestinal RORgammat+ cells are local organizers of mucosal lymphoid tissue...
  21. pmc Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny
    Jelena S Bezbradica
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:5114-9. 2005
    ..Mixed radiation bone marrow chimeras revealed that RORgamma functions in an iNKT cell lineage-specific manner...
  22. ncbi RORgammat recruits steroid receptor coactivators to ensure thymocyte survival
    Huimin Xie
    Department of Microbiology and Immunology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    J Immunol 175:3800-9. 2005
    ..we show that recruitment of SRCs is required for thymic-specific retinoic acid-related orphan receptor gamma (RORgamma)t-regulated thymocyte survival in vivo...
  23. ncbi The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    Ivaylo I Ivanov
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 126:1121-33. 2006
    ..Together, these studies suggest that RORgammat is a key regulator of immune homeostasis and highlight its potential as a therapeutic target in inflammatory diseases...
  24. ncbi Retinoid-related orphan receptor gamma controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen
    Stephen L Tilley
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Immunol 178:3208-18. 2007
    ..b>RORgamma, the most recently identified member of the ROR family, has been shown to be important for the development of ..
  25. ncbi Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism
    Chang Liu
    Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Nature 447:477-81. 2007
    ..We have thus identified PGC-1alpha as a key component of the circadian oscillator that integrates the mammalian clock and energy metabolism...
  26. ncbi Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells
    Dominik Meier
    Division of Developmental Immunology, Center for Biomedicine, Department of Clinical and Biological Sciences DKBW, University of Basel, CH 4058 Basel, Switzerland
    Immunity 26:643-54. 2007
    ..Mice overexpressing IL-7 but lacking either RORgamma, a factor required for LTi cell generation, or lymphotoxin alpha1beta2 had neither Peyer's patches nor ectopic ..
  27. ncbi IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nat Immunol 8:967-74. 2007
    ..IL-6 therefore orchestrates a series of 'downstream' cytokine-dependent signaling pathways that, in concert with TGF-beta, amplify RORgammat-dependent differentiation of T(H)-17 cells...
  28. ncbi Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007
    ..T(H)17 differentiation and suppresses Foxp3 expression, which requires STAT3 and ROR-gamma, which is encoded by Rorc. IL-21 deficiency impairs the generation of T(H)17 cells and results in protection against experimental autoimmune ..
  29. ncbi Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism
    Hong Soon Kang
    Cell Biology Section, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Physiol Genomics 31:281-94. 2007
    ....
  30. doi Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input
    Andrea J White
    MRC Centre for Immune Regulation, Institute for Biomedical Research, University of Birmingham Medical School, Birmingham, UK
    Eur J Immunol 38:942-7. 2008
    ....
  31. pmc Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion
    Aleksandra V Rachitskaya
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 180:5167-71. 2008
    ..These data suggest an important biological role for innate IL-17 production by NKT cells that is rapid and precedes the adaptive IL-17 response...
  32. doi Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Immunity 29:261-71. 2008
    ..formation of ILFs was regulated by interactions between lymphoid tissue-inducer cells expressing the nuclear receptor ROR gamma t (ROR gamma t(+)LTi cells) and stromal cells (SCs)...
  33. doi RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
    Moritz Leppkes
    Institute of Molecular Medicine, University of Mainz, Mainz, Germany
    Gastroenterology 136:257-67. 2009
    ..We analyzed the roles of Th17 cells and the transcription factor retinoic acid receptor-related organ receptor (ROR)gamma, which regulates Th17 differentiation, in chronic intestinal inflammation...
  34. pmc RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    Stephanie L Sanos
    Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Nat Immunol 10:83-91. 2009
    ..IL-22 released by these cells promoted the production of antimicrobial molecules important in the maintenance of mucosal homeostasis...
  35. pmc Critical role of ROR-γt in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation
    Marie Laure Michel
    Faculte de Medecine, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Hopital Necker, Universite Paris Descartes, 161 rue de Sevres, 75743, Paris, Cedex 15, France
    Proc Natl Acad Sci U S A 105:19845-50. 2008
    ..In conclusion, our findings demonstrate an alternative thymic pathway leading to the development of iNKT17 cells that requires ROR-gammat expression...
  36. doi Clock-dependent and independent transcriptional control of the two isoforms from the mouse Rorgamma gene
    Valérie Mongrain
    Laboratory of Molecular Chronobiology, Douglas Mental Health University Institute, Montreal, QC, Canada
    Genes Cells 13:1197-210. 2008
    ..This study aims to investigate the expression of Rorgammaisoforms (Rorgamma and Rorgammat) and characterize the molecular mechanisms underlying their tissue-specific expression...
  37. doi ROR gamma t is dispensable for the development of intestinal mucosal T cells
    T Naito
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Mucosal Immunol 1:198-207. 2008
    ..These results clearly reassert the intraintestinal differentiation of the body's largest peripheral T cell subpopulation...
  38. doi Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    Naoko Satoh-Takayama
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris F 75724, France
    Immunity 29:958-70. 2008
    ..RORgammat-driven diversification of intestinal NKp46+ cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces...
  39. pmc CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets
    Julie C Ribot
    Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Portugal
    Nat Immunol 10:427-36. 2009
    ..Thus, the cytokine profiles of peripheral gammadelta T cells are predetermined mainly by a mechanism involving CD27...
  40. doi Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, RIKEN, Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Science 323:1488-92. 2009
    ..Thus, environmental cues present in gut Peyer's patches promote the selective differentiation of distinct helper T cell subsets, such as TFH cells...
  41. pmc The lymphotoxin LTalpha(1)beta(2) controls postnatal and adult spleen marginal sinus vascular structure and function
    Carlene L Zindl
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 30:408-20. 2009
    ....
  42. pmc Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    Yeonseok Chung
    Department of Immunology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 30:576-87. 2009
    ..Our data thus indicate a critical role of IL-1 in Th17 cell differentiation and this pathway may serve as a unique target for Th17 cell-mediated immunopathology...
  43. pmc Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens
    Javier Rangel-Moreno
    Division of Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY 14642, USA
    Immunity 30:731-43. 2009
    ..These results indicate that the milky spots of the omentum function as unique secondary lymphoid organs that promote immunity to peritoneal antigens...
  44. doi Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    Kazuyo Moro
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 463:540-4. 2010
    ..Thus, FALC Lin(-)c-Kit(+)Sca-1(+) cells are T(H)2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'...
  45. doi The IL-7 signaling pathway regulates lymph node development independent of peripheral lymphocytes
    Stephane Chappaz
    Department of Biomedicine, University of Basel, Basel, Switzerland
    J Immunol 184:3562-9. 2010
    ....
  46. pmc Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    Sofia Buonocore
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Nature 464:1371-5. 2010
    ..The transcription factor ROR-gammat, which controls IL-23R expression, has a functional role, because Rag-/-Rorc-/- mice failed to develop innate colitis...
  47. pmc Shared dependence on the DNA-binding factor TOX for the development of lymphoid tissue-inducer cell and NK cell lineages
    Parinaz Aliahmad
    Department of Biomedical Sciences, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Immunol 11:945-52. 2010
    ..Thus, many cell lineages of the immune system share a TOX-dependent step for development...
  48. doi IL-12 initiates tumor rejection via lymphoid tissue-inducer cells bearing the natural cytotoxicity receptor NKp46
    Maya Eisenring
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Nat Immunol 11:1030-8. 2010
    ..Thus, this innate cell type is responsive to IL-12 and is a powerful mediator of tumor suppression...
  49. pmc Regulated expression of nuclear receptor RORγt confers distinct functional fates to NK cell receptor-expressing RORγt(+) innate lymphocytes
    Cedric Vonarbourg
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, 79104 Freiburg, Germany
    Immunity 33:736-51. 2010
    ..Our data also define a previously unappreciated role of RORγt⁻ NKR-LTi cells for the onset or maintenance of inflammatory bowel diseases...
  50. pmc Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells
    Matthias Lochner
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 208:125-34. 2011
    ..However, this comes at a high cost for the host and can lead to a deregulated B cell response and aggravated inflammatory pathology...
  51. doi Runx1/Cbfβ2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages
    Masashi Tachibana
    Laboratory for Transcriptional Regulation, Research Center for Allergy and Immunology, RIKEN, Yokohama 230 0045, Japan
    J Immunol 186:1450-7. 2011
    ....
  52. pmc Retinoic acid-related orphan receptor γ directly regulates neuronal PAS domain protein 2 transcription in vivo
    Yukimasa Takeda
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 39:4769-82. 2011
    ..Our results indicate that RORγ and Rev-Erbα are part of a feed-back loop that regulates the circadian expression of Npas2 suggesting a regulatory role for these receptors in Npas2-dependent physiological processes...
  53. doi RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    Laura Codarri
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Nat Immunol 12:560-7. 2011
    ..Thus, in contrast to all other known helper T cell-derived cytokines, GM-CSF serves a nonredundant function in the initiation of autoimmune inflammation regardless of helper T cell polarization...
  54. pmc Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis
    Hong Soon Kang
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Physiol Genomics 43:818-28. 2011
    ..Our study indicates that RORα plays a critical role in the regulation of several aspects of metabolic syndrome. Therefore, RORα may provide a novel therapeutic target in the management of obesity and associated metabolic diseases...
  55. pmc Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein
    Tao Xu
    Gladstone Institute of Cardiovascular Disease, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94158, USA
    J Biol Chem 286:22707-10. 2011
    ..The results thus suggest UA as a valuable drug candidate or leading compound for developing treatments of Th17-mediated inflammatory diseases and cancer...
  56. pmc Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma
    Bettina Meissburger
    ETH Zurich, Institute of Food Nutrition and Health, Schwerzenbach, Switzerland
    EMBO Mol Med 3:637-51. 2011
    ..RORγ might therefore serve as a novel pharmaceutical target to treat obesity-associated insulin resistance...
  57. pmc Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    Eric V Dang
    Immunology and Hematopoiesis Division, Department of Oncology and Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Maryland 21231, USA
    Cell 146:772-84. 2011
    ..These findings highlight the importance of metabolic cues in T cell fate determination and suggest that metabolic modulation could ameliorate certain T cell-based immune pathologies...
  58. doi Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles
    Elina A Kiss
    Institute of Medical Microbiology and Hygiene, University of Freiburg Medical Center, Freiburg, Germany
    Science 334:1561-5. 2011
    ..Our results establish a molecular link between nutrients and the formation of immune system components required to maintain intestinal homeostasis and resistance to infections...
  59. pmc AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
    Jacob S Lee
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 13:144-51. 2011
    ..Thus, AHR was essential for ILC22 cells and postnatal intestinal lymphoid tissues. Moreover, ILC22 subsets were heterogeneous in their requirement for Notch and their effect on the generation of intestinal lymphoid tissues...
  60. pmc Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells
    Marie Cherrier
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    J Exp Med 209:729-40. 2012
    ..Notch is therefore a necessary switch to engage the LTi developmental pathway, but needs to be turned off later to avoid diversion to the T cell fate...
  61. doi Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation
    Timotheus Y F Halim
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC V5Z 1L3, Canada
    Immunity 37:463-74. 2012
    ..We have also identified RORα-dependent NH cell progenitors in the bone marrow. Thus, all NH cells belong to a unique RORα-dependent cell lineage separate from other lymphoid cell lineages...
  62. pmc A validated regulatory network for Th17 cell specification
    Maria Ciofani
    Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
    Cell 151:289-303. 2012
    ..This interconnected network can be used to investigate new therapeutic approaches to manipulate Th17 functions in the setting of inflammatory disease...
  63. pmc The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells
    Thomas Hoyler
    IMMH, Institute of Medical Microbiology and Hygiene, University of Freiburg, Germany
    Immunity 37:634-48. 2012
    ..Thus, our data demonstrate that GATA-3 is essential for ILC2 fate decisions and reveal similarities between the transcriptional programs controlling ILC and T helper cell fates...
  64. doi A T-bet gradient controls the fate and function of CCR6-RORγt+ innate lymphoid cells
    Christoph S N Klose
    Institute of Medical Microbiology and Hygiene, University of Freiburg, Hermann Herder Strasse 11, D 79104 Freiburg, Germany
    Nature 494:261-5. 2013
    ....
  65. pmc Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation
    Yukimasa Takeda
    Division of Intramural Research, Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 41:6992-7008. 2013
    ..Our data suggest that Prox1 is part of a feedback loop that negatively regulates the transcriptional control of clock and metabolic networks by RORs. ..
  66. pmc Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells
    Giuliana Magri
    1 Institut Hospital del Mar d Investigacions Mèdiques, Barcelona, Spain 2
    Nat Immunol 15:354-64. 2014
    ..Thus, ILCs integrate stromal and myeloid signals to orchestrate innate-like antibody production at the interface between the immune system and circulatory system. ..
  67. pmc Retinoic acid-related orphan receptor γ (RORγ): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity
    Yukimasa Takeda
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America
    PLoS Genet 10:e1004331. 2014
    ..The inhibition of the activation of several metabolic gene promoters by an RORγ antagonist suggests that antagonists may provide a novel strategy in the management of metabolic diseases, including type 2 diabetes...
  68. ncbi Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene
    A Medvedev
    Cell Biology Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genomics 46:93-102. 1997
    ..mouse ROR gamma and the chromosomal localization of both mouse ROR gamma and human ROR gamma (HGMW-approved symbol RORC)...
  69. ncbi Retinoid-related orphan receptor gamma regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production
    Suryaprakash Raichur
    Institute for Molecular Bioscience, University of Queensland St Lucia, 4072, Queensland, Australia
    J Mol Endocrinol 39:29-44. 2007
    Retinoid-related orphan receptor gamma (RORgamma) is an orphan nuclear hormone receptor (NR) that is preferentially expressed in skeletal muscle and several other tissues, including pancreas, thymus, prostate, liver and testis...
  70. doi Cutting edge: IL-7 regulates the peripheral pool of adult ROR gamma+ lymphoid tissue inducer cells
    Sandrine Schmutz
    Division of Developmental Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland
    J Immunol 183:2217-21. 2009
    ..Our observations demonstrate that adult CD4(+)lineage(-) cells are LTi cells and that the availability of IL-7 determines the size of the adult LTi cell pool...
  71. pmc T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway
    Ruiqing Wang
    Division of Immunology, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA
    J Immunol 187:5964-73. 2011
    ..Therefore, our data demonstrated that TCF-1 enhances DP thymocyte survival through transcriptional upregulation of RORγt, which we previously showed is an essential prosurvival molecule for DP thymocytes...
  72. pmc The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
    Ju Qiu
    Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Immunity 36:92-104. 2012
    ..Our data uncover a previously unrecognized physiological role for Ahr in promoting innate gut immunity by regulating RORγt(+) ILCs...
  73. pmc Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma
    Maho Suzukawa
    Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173 8605, Japan
    J Immunol 189:3641-52. 2012
    ..It is not required for Ag-specific Th2 cell differentiation in the sensitization phase...
  74. pmc Runx1 and Runx3 are involved in the generation and function of highly suppressive IL-17-producing T regulatory cells
    Lequn Li
    Department of Medicine, Division of Hematology Oncology and Cancer Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e45115. 2012
    ..Our studies indicate that Tr17 cells concomitantly express Foxp3, RORγt, Runx1 and Runx3 and are capable of producing IL-17 while mediating potent suppressive and cytotoxic function...
  75. doi Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection
    André Gladiator
    Institute of Microbiology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    J Immunol 190:521-5. 2013
    ..Taken together, our data uncover the cellular basis for the IL-23/IL-17 axis, which acts right at the onset of infection when it is most needed for fungal control and host protection...
  76. pmc T helper type 17 cells contribute to anti-tumour immunity and promote the recruitment of T helper type 1 cells to the tumour
    Sarah Nuñez
    Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
    Immunology 139:61-71. 2013
    ..Our results suggest that Th17 cells do not affect the recruitment of immunosuppressive populations but favour the recruitment of effector Th1 cells to the tumour, thereby promoting anti-tumour responses...
  77. doi Transcription factors GATA-3 and RORγt are important for determining the phenotype of allergic airway inflammation in a murine model of asthma
    Satoshi Ano
    Division of Clinical Medicine, Department of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    J Immunol 190:1056-65. 2013
    ..Furthermore, blockade of the Th17-signaling pathway may be a treatment option for steroid-insensitive asthma...
  78. pmc Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 38:769-81. 2013
    ..Thus, intraepithelial ILC1 may initiate IFN-γ responses against pathogens but contribute to pathology when dysregulated...
  79. ncbi Jagged-1-HES-1 signaling inhibits the differentiation of TH17 cells via ROR gammat
    P You
    Department of Immunobiology, Jinan University, Guangzhou, China
    J Biol Regul Homeost Agents 27:79-93. 2013
    ..The results indicate that Jagged-1-Hes-1 signaling can suppress the skewing of CD4+ T cells toward Th17 cells via RORgammat, for which Hes-1 may be crucial...
  80. ncbi ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle
    T Hirose
    Cell Biology Section, Laboratory of Pulmonary Pathobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709
    Biochem Biophys Res Commun 205:1976-83. 1994
    ..ROR gamma was localized on human chromosome 1. Northern blot analysis using RNA from multiple tissues indicated that ROR gamma is expressed in several tissues but is most highly expressed in skeletal muscle...
  81. ncbi Orphan nuclear receptors in T lymphocyte development
    You Wen He
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Leukoc Biol 72:440-6. 2002
    ..The orphan nuclear receptor RORgamma has been shown to promote thymocyte survival by activating the expression of antiapoptotic protein Bcl-x(L)...
  82. ncbi Lymphocyte accumulation in the spleen of retinoic acid receptor-related orphan receptor gamma-deficient mice
    Nu Zhang
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 171:1667-75. 2003
    The hormone nuclear receptor retinoic acid receptor-related orphan receptor gamma (RORgamma) plays important roles in thymocyte development and lymphoid organogenesis...
  83. ncbi IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells
    Zdena Tuhácková
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 166 37 Prague 6, Czech Republic
    Int J Mol Med 13:601-5. 2004
    ..The data support the hypothesis that Akt may act downstream to PI-3K and upstream to mTOR in an IL2-mediated signal transduction pathway that controls phosphorylation of the regulatory protein S6 in CTLL2 cells...
  84. pmc Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination
    Iratxe Abarrategui
    Department of Immunology, Duke University Medical Center, Durham, NC, USA
    EMBO J 26:4380-90. 2007
    ..The ability of TEA transcription to coordinate the activity of multiple downstream promoters maximizes the biological potential of the Jalpha array and diversifies the Tcra repertoire...
  85. pmc Lymph sacs are not required for the initiation of lymph node formation
    Mark F Vondenhoff
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Development 136:29-34. 2009
    ..5 Prox1 conditional mutant embryos, which have defective lymph sacs. However, subsequent clustering of hematopoietic cells within these developing lymph nodes is less efficient...
  86. pmc IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype
    Magdalena Huber
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Marburg, 35043 Marburg, Germany
    Proc Natl Acad Sci U S A 105:20846-51. 2008
    ..These data highlight IRF4 as a decisive factor during the IL-21-mediated steps of Th17 development by influencing the balance of Foxp3, RORalpha, and RORgammat...
  87. pmc Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activation
    Sumanta Mukherjee
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 182:7381-8. 2009
    ..These studies further demonstrate that Dll4 up-regulates Rorc expression in T cells and that both Rorc and Il17 gene promoters are direct transcriptional notch targets that ..
  88. pmc Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity
    Takahiro Nagatake
    Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 206:2351-64. 2009
    ..Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity...
  89. doi Natural occurring IL-17 producing T cells regulate the initial phase of neutrophil mediated airway responses
    Shinya Tanaka
    Laboratory for Signal Network, Research Center for Allergy and Immunology, RIKEN Yokohama Institute, Tsurumi, Yokohama, Kanagawa, Japan
    J Immunol 183:7523-30. 2009
    ..10 Rag(-/-) mice. These results demonstrate that a novel T cell subset, nTh17, facilitates the early phase of Ag-induced airway responses and host defenses against pathogen invasion before the establishment of acquired immunity...
  90. doi Induction of lymphoidlike stroma and immune escape by tumors that express the chemokine CCL21
    Jacqueline D Shields
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Science 328:749-52. 2010
    ..We suggest that by altering the tumor microenvironment, CCL21-secreting tumors shift the host immune response from immunogenic to tolerogenic, which facilitates tumor progression...
  91. pmc Smad2 positively regulates the generation of Th17 cells
    Gustavo J Martinez
    Department of Immunology and Center for Inflammation and Cancer, MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:29039-43. 2010
    ..These results demonstrate that Smad2 positively regulates the generation of inflammatory Th17 cells...
  92. pmc Cutting edge: The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORγt
    Lori Lebson
    Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 185:7161-4. 2010
    ....
  93. pmc Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation
    Guoliang Cui
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Graduate School of CAS, Chinese Academy of Sciences, Shanghai, China
    J Clin Invest 121:658-70. 2011
    ..This study reports what we believe to be a novel signaling pathway underlying LXR-mediated regulation of Th17 cell differentiation and autoimmunity...
  94. pmc Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency
    Yohei Kawai
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 108:4075-80. 2011
    ..These results suggest that Cld4 is induced by E-protein activity in the later stages of DP cells to increase the efficiency of positive selection, uncovering a hitherto unrecognized function of a Cld family protein...
  95. doi RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
    Shinichiro Sawa
    Institut Pasteur, Lymphoid Tissue Development Unit, Paris, France
    Nat Immunol 12:320-6. 2011
    ..Our data identify a finely tuned equilibrium among intestinal symbionts, adaptive immunity and RORγt+ ILCs...
  96. pmc Control of epithelial cell function by interleukin-22-producing RORγt+ innate lymphoid cells
    Stephanie L Sanos
    IMMH, University of Freiburg, Freiburg, Germany
    Immunology 132:453-65. 2011
    ..This review will highlight recent progress in understanding development and function of innate IL-22-producing lymphocyte subsets...
  97. doi RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells
    Iwona Powolny-Budnicka
    Immunology Group, Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
    Immunity 34:364-74. 2011
    ..Thus, RelA and RelB within different thymocyte subpopulations cooperate in the regulation of IL-17 production by γδ T cells and contribute to the host's ability to fight bacterial infections...
  98. doi Notch-Hes1 pathway is required for the development of IL-17-producing γδ T cells
    Kensuke Shibata
    Division of Host Defense, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    Blood 118:586-93. 2011
    ..In addition, conditional Hes1 ablation in peripheral γδ T cells decreases their IL-17 production but not their IFN-γ production. These results reveal a unique differentiation pathway of IL-17-producing γδ T cells...
  99. doi IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis
    Tomomi Yamashita
    Department of Clinical Pharmacology and Pharmacogenomics, Graduate School of Pharmaceutical Science, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Cardiovasc Res 91:640-8. 2011
    ..IL-6 gene ablation confers the resistance to experimental autoimmune myocarditis (EAM). In this study, we have addressed the pathological roles of IL-6 in the regulation of Th17 cells in EAM...
  100. ncbi TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals
    M A Ortiz
    La Jolla Cancer Research Foundation, California 92037, USA
    Mol Endocrinol 9:1679-91. 1995
    ..This new receptor, TOR (thymus orphan receptor), is most closely related in both its DNA-binding domain and ligand-binding domain, 90% and 53%, ..
  101. pmc Rorgamma (Rorc) is a common integration site in type B leukemogenic virus-induced T-cell lymphomas
    Dana R Broussard
    Section of Microbiology and Molecular Genetics and Institute of Cellular and Molecular Biology, Austin, Texas 78712, USA
    J Virol 78:4943-6. 2004
    The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Rorgamma locus as an integration site in 19% of TBLV-induced tumors...

Research Grants5

  1. ADENOSINE RECEPTORS IN ALLERGIC INFLAMMATION
    Stephen Tilley; Fiscal Year: 2004
    ..abstract_text> ..
  2. Role of propionibacteria in sarcoidosis
    Stephen Tilley; Fiscal Year: 2005
    ..Future directions will include a placebo-controlled trial of tetracyclines for sarcoidosis if Propionibacteria are identified. ..
  3. ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATION
    You Wen He; Fiscal Year: 2006
    ..In addition, results from this application will also provide insights for the role of ROR-gamma-t in tumorigenesis. ..
  4. Extracellular Matrix Protein in Innate Immunity
    You Wen He; Fiscal Year: 2007
    ..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
  5. Pattern Recognition Molecule Mindin As Adjuvant
    You Wen He; Fiscal Year: 2007
    ..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..