Ripk1

Summary

Gene Symbol: Ripk1
Description: receptor (TNFRSF)-interacting serine-threonine kinase 1
Alias: D330015H01Rik, RIP, Rinp, Rip1, receptor-interacting serine/threonine-protein kinase 1, RIP-1, cell death protein RIP, receptor-interacting protein 1, serine/threonine-protein kinase RIP
Species: mouse

Top Publications

  1. ncbi The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2
    Thomas H Lee
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 279:33185-91. 2004
  2. doi TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations
    Yechen Xiao
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Blood 118:6057-67. 2011
  3. pmc IAPs limit activation of RIP kinases by TNF receptor 1 during development
    Maryline Moulin
    La Trobe Institute for Molecular Science, La Trobe University, Victoria, Australia
    EMBO J 31:1679-91. 2012
  4. pmc NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells
    Yoshiaki Tamura
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Charlestown, MA 02129, USA
    FEBS Lett 585:3058-64. 2011
  5. pmc The dual functions of receptor interacting protein 1 in fas-induced hepatocyte death during sepsis
    Sam I McNeal
    Division of Surgical Research Department of Surgery, Rhode Island Hospital, Providence, Rhode Island, USA
    Shock 35:499-505. 2011
  6. pmc Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway
    Peter Broglie
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Biol Chem 285:2333-9. 2010
  7. pmc In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8
    Ian E Gentle
    Department of Biochemistry and La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia
    J Biol Chem 286:13282-91. 2011
  8. pmc Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
    Sean L Petersen
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cancer Cell 12:445-56. 2007
  9. ncbi IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
    Cell 131:682-93. 2007
  10. doi RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
    Duan Wu Zhang
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    Science 325:332-6. 2009

Research Grants

Scientific Experts

  • William J Kaiser
  • Igor E Brodsky
  • Edward Mocarski
  • R Chavez-Valdez
  • Yong Lin
  • M Melnick
  • K Hofmann
  • M A Kelliher
  • Aristides G Eliopoulos
  • Sabine Gröbner
  • Marie Anne O'Donnell
  • Francis Ka Ming Chan
  • John Silke
  • Peter J Gough
  • John Bertin
  • N Vanlangenakker
  • Noula Shembade
  • Zheng Gang Liu
  • Yves Dondelinger
  • Scott B Berger
  • Peter Vandenabeele
  • Thomas McQuade
  • Maryline Moulin
  • You Sun Kim
  • Jianke Zhang
  • David L Vaux
  • T Vanden Berghe
  • P Vandenabeele
  • Gang Min Hur
  • Rebecca Feltham
  • Mikyoung Chang
  • Jun Zhang
  • Nicole Cusson
  • Timothy J LaRocca
  • Yi Zhi Wang
  • Michael J Morgan
  • Seokwon Kang
  • Yanfang Xu
  • Hyun Kyoung Lee
  • Sue Kyung Kim
  • Douglas R Green
  • Andrew Oberst
  • Tohru Yonekawa
  • Maria Feoktistova
  • Nader Yatim
  • Chuan Jin Wu
  • Katherine A Fitzgerald
  • Siddharth Balachandran
  • Linda Roback
  • W D Cook
  • Chenyang Zhao
  • H W Zheng
  • Viera Kasparcova
  • Joshua Finger
  • Dan Weng
  • Pratyusha Mandal
  • Carla M Cuda
  • Mathieu J M Bertrand
  • Ken Blackwell
  • Ryodai Shindo
  • Timothy T Lu
  • Colleen R McNamara
  • Kota Sato
  • Yuan Chao Ye
  • Linde Duprez
  • Jiahuai Han
  • Seong Keun Kim
  • Wendy Wei Lynn Wong
  • Mina Kikuchi
  • Andreas Linkermann
  • D L Vaux
  • Nirmal Robinson
  • D E Christofferson
  • Jing Shao
  • Martinus I F J Oerlemans
  • Rune Busk Damgaard
  • Aleksandra Bankovacki
  • Wendy D Cook
  • Holly Anderton
  • Haibing Zhang
  • Yoshiaki Tamura
  • Parameswaran Ramakrishnan
  • Seda Çöl Arslan
  • Nele Festjens
  • P Bogaert
  • Sam I McNeal
  • Yibin Yang
  • Yechen Xiao
  • Roshan J Thapa
  • Ian E Gentle

Detail Information

Publications96

  1. ncbi The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2
    Thomas H Lee
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 279:33185-91. 2004
    The death domain kinase Rip1 is recruited to the tumor necrosis factor receptor type 1 and mediates the IkappaB kinase and p38 MAP kinase pathways...
  2. doi TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations
    Yechen Xiao
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Blood 118:6057-67. 2011
    ..This TNF-α/Fas-induced cell death is a type of receptor-interacting protein-1 (RIP-1)-dependent programmed necrosis called necroptosis, which can be prevented by necrostatin-1, a specific RIP-1 ..
  3. pmc IAPs limit activation of RIP kinases by TNF receptor 1 during development
    Maryline Moulin
    La Trobe Institute for Molecular Science, La Trobe University, Victoria, Australia
    EMBO J 31:1679-91. 2012
    ..Remarkably, hemizygosity for receptor-interacting protein kinase 1 (Ripk1) allowed Xiap(-/-)cIap1(-/-) double mutants to survive past birth, and prolonged cIap2(-/-)cIap1(-/-) embryonic ..
  4. pmc NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells
    Yoshiaki Tamura
    Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Shriners Hospitals for Children, Harvard Medical School, Charlestown, MA 02129, USA
    FEBS Lett 585:3058-64. 2011
    ..Recently, receptor-interacting protein-1 (RIP1)-dependent necrosis, which is inhibited by necrostatin-1, an inhibitor of RIP1, has emerged as a form of regulated ..
  5. pmc The dual functions of receptor interacting protein 1 in fas-induced hepatocyte death during sepsis
    Sam I McNeal
    Division of Surgical Research Department of Surgery, Rhode Island Hospital, Providence, Rhode Island, USA
    Shock 35:499-505. 2011
    ..Recently, an adaptor protein associated with the Fas/TNF death receptor pathway, receptor interacting protein 1 (RIP1), has been shown to be critical for determining whether a cell's death is apoptotic or necrotic...
  6. pmc Transforming growth factor beta-activated kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway
    Peter Broglie
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Biol Chem 285:2333-9. 2010
    ..Our results indicate that TAB2 not only activates TAK1 but also plays an essential role in the deactivation of TAK1 by recruiting PP6 through a polyubiquitin chain-dependent mechanism...
  7. pmc In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-kappaB and activation of caspase-8
    Ian E Gentle
    Department of Biochemistry and La Trobe Institute for Molecular Science, La Trobe University, Victoria 3086, Australia
    J Biol Chem 286:13282-91. 2011
    b>RIPK1 is involved in signaling from TNF and TLR family receptors. After receptor ligation, RIPK1 not only modulates activation of both canonical and NIK-dependent NF-κB, but also regulates caspase-8 activation and cell death...
  8. pmc Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
    Sean L Petersen
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cancer Cell 12:445-56. 2007
    ..In response to autocrine TNFalpha signaling, the Smac mimetic promotes formation of a RIPK1-dependent caspase-8-activating complex, leading to apoptosis.
  9. ncbi IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
    James E Vince
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia
    Cell 131:682-93. 2007
    ..Cells treated with an IAC, or those in which cIAP1 was deleted, became sensitive to apoptosis induced by exogenous TNFalpha, suggesting novel uses of these compounds in treating cancer...
  10. doi RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
    Duan Wu Zhang
    Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, China
    Science 325:332-6. 2009
    ..RIP3 did not affect RIP1-mediated apoptosis but was required for RIP1-mediated necrosis and the enhancement of necrosis by the caspase ..
  11. pmc Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    Young Sik Cho
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cell 137:1112-23. 2009
    ..The kinase RIP1 is crucial for programmed necrosis, but also mediates activation of the prosurvival transcription factor NF-kappaB...
  12. pmc Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1
    Gufeng Xu
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:969-78. 2010
    Ubiquitination and deubiquitination of receptor-interacting protein 1 (RIP1) play an important role in the positive and negative regulation of the tumor necrosis factor alpha (TNFalpha)-induced nuclear factor kappaB (NF-kappaB) activation...
  13. doi RIPK1 is not essential for TNFR1-induced activation of NF-kappaB
    W W L Wong
    Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, Victoria 3086, Australia
    Cell Death Differ 17:482-7. 2010
    On TNF binding, receptor-interacting protein kinase 1 (RIPK1) is recruited to the cytoplasmic domain of TNFR1, at which it becomes ubiquitylated and serves as a platform for recruitment and activation of NEMO/IKK1/IKK2 and TAK1/TAB2...
  14. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
    ..linkage types and that its recruitment to the TNF-RSC is impaired in TRADD-, TRAF2-, and cIAP1/2- but not in RIP1- or NEMO-deficient MEFs...
  15. pmc cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production
    N Vanlangenakker
    Department for Molecular Biomedical Research, VIB, Technologiepark 927, Zwijnaarde Ghent 9052, Belgium
    Cell Death Differ 18:656-65. 2011
    ..but block apoptosis by functioning as E3 ligases for effector caspases and receptor-interacting protein 1 (RIP1)...
  16. pmc Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis
    George Trichonas
    Retina Service, Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:21695-700. 2010
    ..RIP3 expression, a key activator of RIP1 kinase, increased more than 10-fold after retinal detachment...
  17. ncbi The death domain kinase RIP mediates the TNF-induced NF-kappaB signal
    M A Kelliher
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 8:297-303. 1998
    The death domain serine/threonine kinase RIP interacts with the death receptors Fas and tumor necrosis receptor 1 (TNFR1). In vitro, RIP stimulates apoptosis, SAPK/JNK, and NF-kappaB activation...
  18. pmc Functional complementation between FADD and RIP1 in embryos and lymphocytes
    Haibing Zhang
    Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nature 471:373-6. 2011
    ..FADD could directly bind to RIP1 (also known as RIPK1), a serine/threonine kinase that mediates both necrosis and NF-κB activation...
  19. pmc RIP3 mediates the embryonic lethality of caspase-8-deficient mice
    William J Kaiser
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 471:368-72. 2011
    ..Casp8 suppresses RIP3-RIP1 (also known as RIPK3-RIPK1) kinase complex-dependent necroptosis that follows death receptor activation as well as a RIP3-dependent, RIP1-..
  20. pmc Caspase 8 inhibits programmed necrosis by processing CYLD
    Marie Anne O'Donnell
    Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nat Cell Biol 13:1437-42. 2011
    ..of caspase 8 is to transmit a pro-survival signal that suppresses programmed necrosis (or necroptosis) mediated by RIPK1 and RIPK3 (refs 2-6) during embryogenesis and haematopoiesis(7-9)...
  21. pmc TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members
    N Vanlangenakker
    Department for Molecular Biomedical Research, VIB, Zwijnaarde Ghent, Belgium
    Cell Death Dis 2:e230. 2011
    ..We previously reported that cellular inhibitor of apoptosis protein-mediated receptor-interacting protein 1 (RIP1) ubiquitination acts as a cytoprotective mechanism, whereas knockdown of cylindromatosis, a RIP1-deubiquitinating ..
  22. doi Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury
    Andreas Linkermann
    Division of Nephrology and Hypertension, Christian Albrechts University, Kiel, Germany
    Kidney Int 81:751-61. 2012
    ..Necrostatin-1 may have therapeutic potential to prevent and treat renal ischemia/reperfusion injury...
  23. pmc A novel role for RIP1 kinase in mediating TNFα production
    D E Christofferson
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell Death Dis 3:e320. 2012
    Receptor-interacting protein 1 (RIP1) is a Ser/Thr kinase with both kinase-dependent and kinase-independent roles in death receptor signaling...
  24. pmc Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium
    Nirmal Robinson
    National Research Council of Canada Institute for Biological Sciences, Ottawa, Canada
    Nat Immunol 13:954-62. 2012
    ..Typhimurium-induced cell death. Specific inhibition of the kinase RIP1 or knockdown of the gene encoding the kinase RIP3 prevented the death of wild-type macrophages, which indicated ..
  25. ncbi The essential role of the death domain kinase receptor-interacting protein in insulin growth factor-I-induced c-Jun N-terminal kinase activation
    Yong Lin
    Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    J Biol Chem 281:23525-32. 2006
    ..Here, we show that the receptor-interacting protein (RIP), a key mediator of tumor necrosis factor-induced NF-kappaB and JNK activation, plays a key role in IGF-I receptor ..
  26. pmc The role of the death-domain kinase RIP in tumour-necrosis-factor-induced activation of mitogen-activated protein kinases
    Anne Devin
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    EMBO Rep 4:623-7. 2003
    The death-domain kinase RIP (receptor-interacting protein) is an important effector of tumour necrosis factor (TNF) signalling and is essential for TNF-induced nuclear factor-kappaB activation...
  27. pmc The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death
    Nicole Cusson
    Department of Molecular Genetics and Microbiology, Program in Immunology Virology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Exp Med 196:15-26. 2002
    ..The death domain kinase, receptor interacting protein (rip), is recruited to the TNFR1 upon receptor activation...
  28. ncbi RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
    B Z Stanger
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 81:513-23. 1995
    ..products that associate with the intracellular domain of Fas: Fas itself, and a novel 74 kDa protein we have named RIP, for receptor interacting protein...
  29. pmc Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death
    Han Ming Shen
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 24:5914-22. 2004
    ..Data from this study suggest that receptor-interacting protein (RIP) and tumor necrosis factor receptor (TNFR)-associated factor 2 (TRAF2), two key effector molecules of TNF signaling,..
  30. pmc RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation
    Marina S Vivarelli
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 200:399-404. 2004
    Receptor-interacting protein (RIP) has been reported to associate with tumor necrosis-associated factor (TRAF)2 and TRAF6...
  31. ncbi Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]
    Chuan Jin Wu
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Cell Biol 8:398-406. 2006
    ..attachment of Lys 63-linked polyubiquitin chains to signalling intermediates such as receptor-interacting protein (RIP)...
  32. ncbi RIP1, a kinase on the crossroads of a cell's decision to live or die
    N Festjens
    Molecular Signalling and Cell Death Unit, Department for Molecular Biomedical Research, VIB and Ghent University, Ghent, Belgium
    Cell Death Differ 14:400-10. 2007
    ..b>RIP1 is a crucial adaptor kinase on the crossroad of these stress-induced signalling pathways and a cell's decision to ..
  33. pmc Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling
    Marie Anne O'Donnell
    Immunobiology Center, Mount Sinai School of Medicine, Box 1630, One Gustave L Levy Place, New York, NY 10029, USA
    Curr Biol 17:418-24. 2007
    ..We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, ..
  34. ncbi Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD
    Ato Wright
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Dev Cell 13:705-16. 2007
    ..We further show that CYLD negatively regulates a ubiquitin-dependent NF-kappaB activator, RIP1. CYLD binds to RIP1 and inhibits its ubiquitination and signaling function...
  35. pmc Caspase-8 acts as a molecular rheostat to limit RIPK1- and MyD88-mediated dendritic cell activation
    Carla M Cuda
    Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611
    J Immunol 192:5548-60. 2014
    ..Uncontrolled TLR activation in a RIPK1-dependent manner is responsible for the enhanced functionality of caspase-8-deficient DCs, because deletion of the ..
  36. pmc Hyperglycemic Conditions Prime Cells for RIP1-dependent Necroptosis
    Timothy J LaRocca
    From the Department of Basic and Social Sciences, Albany College of Pharmacy and Health Sciences, Albany, New York 12208
    J Biol Chem 291:13753-61. 2016
    Necroptosis is a RIP1-dependent programmed cell death (PCD) pathway that is distinct from apoptosis...
  37. pmc Intermediate domain of receptor-interacting protein kinase 1 (RIPK1) determines switch between necroptosis and RIPK1 kinase-dependent apoptosis
    Linde Duprez
    Department for Molecular Biomedical Research VIB, Ghent University, Technologiepark 927, Gent Zwijnaarde 9052, Belgium
    J Biol Chem 287:14863-72. 2012
    Receptor-interacting protein kinase 1 (RIPK1) is an important component of the tumor necrosis factor receptor 1 (TNFR1) signaling pathway...
  38. pmc Tissue acidosis induces neuronal necroptosis via ASIC1a channel independent of its ionic conduction
    Yi Zhi Wang
    Discipline of Neuroscience, Department of Anatomy, Histology and Embryology, Collaborative Innovation Center for Brain Science, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    elife 4:. 2015
    ..We identified serine/threonine kinase receptor interaction protein 1 (RIP1) as a critical component of this form of neuronal necroptosis...
  39. pmc Two coordinated mechanisms underlie tumor necrosis factor alpha-induced immediate and delayed IκB kinase activation
    Ken Blackwell
    Department of Pathology, Carver College of Medicine, USA
    Mol Cell Biol 33:1901-15. 2013
    ..necrosis factor alpha (TNF-α)-induced NF-κB activation has been believed to depend on TRAF2- and cIAP1-mediated RIP1 ubiquitination...
  40. pmc Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis
    Thomas McQuade
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, U S A
    Biochem J 456:409-15. 2013
    ..of two serine/threonine kinases, RIP1 (receptor-interacting serine/threonine protein kinase 1; also known as RIPK1) and RIP3...
  41. pmc Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein
    Kota Sato
    Department of Ophthalmology and Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, Electron Microscope Laboratory, Tulane University, New Orleans, Louisiana 70118, Department of Ophthalmology, Georgia Health Sciences University, Augusta, Georgia 30912, and Jules Stein Eye Institute, The University of California, Los Angeles School of Medicine, Los Angeles, California 90095
    J Neurosci 33:17458-68. 2013
    ..We found that receptor interacting protein 1 and 3 (RIP1 and RIP3) kinases, the intracellular key mediators of TNF-induced cellular necrosis, were ..
  42. pmc RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells
    Nader Yatim
    Laboratory of Dendritic Cell Biology, Department of Immunology, Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France Institut National de la Santé et de la Recherche Médicale, U818, 25 rue du Docteur Roux, 75015 Paris, France Frontières du Vivant Doctoral School, École Doctorale 474, Universite Paris Diderot Paris 7, Sorbonne Paris Cité, 8 10 Rue Charles V, 75004 Paris, France
    Science 350:328-34. 2015
    ..Instead, robust cross-priming required receptor-interacting protein kinase-1 (RIPK1) signaling and nuclear factor κB (NF-κB)-induced transcription within dying cells...
  43. doi NF-κB-Independent Role of IKKα/IKKβ in Preventing RIPK1 Kinase-Dependent Apoptotic and Necroptotic Cell Death during TNF Signaling
    Yves Dondelinger
    Inflammation Research Center, VIB, Technologiepark 927, Zwijnaarde Ghent 9052, Belgium Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, Zwijnaarde Ghent 9052, Belgium
    Mol Cell 60:63-76. 2015
    TNF is a master pro-inflammatory cytokine. Activation of TNFR1 by TNF can result in both RIPK1-independent apoptosis and RIPK1 kinase-dependent apoptosis or necroptosis...
  44. pmc Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
    Dan Weng
    Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine
    Proc Natl Acad Sci U S A 111:7391-6. 2014
    ..Interestingly, macrophages lacking either RIP1, or caspase-8 and RIP3, also had reduced infection-induced production of IL-1β, IL-18, TNF, and IL-6; impaired ..
  45. pmc Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3
    Seokwon Kang
    Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Nat Commun 6:7515. 2015
    ..that TLR3 binding to dsRNA promotes post-translational inflammasome activation through intermediate and late TRIF/RIPK1/FADD-dependent pathways...
  46. pmc Cutting Edge: RIP1 kinase activity is dispensable for normal development but is a key regulator of inflammation in SHARPIN-deficient mice
    Scott B Berger
    Pattern Recognition Receptor Discovery Performance Unit, Immuno inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19422
    J Immunol 192:5476-80. 2014
    RIP1 (RIPK1) kinase is a key regulator of TNF-induced NF-κB activation, apoptosis, and necroptosis through its kinase and scaffolding activities...
  47. pmc Receptor-interacting protein kinases modulate noise-induced sensory hair cell death
    H W Zheng
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Cell Death Dis 5:e1262. 2014
    ..b>RIP1 and RIP3 protein levels increased and caspase-8 was activated...
  48. pmc Apcdd1 stimulates oligodendrocyte differentiation after white matter injury
    Hyun Kyoung Lee
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas
    Glia 63:1840-9. 2015
    ....
  49. pmc RIPK1- and RIPK3-induced cell death mode is determined by target availability
    W D Cook
    La Trobe Institute for Molecular Science, La Trobe University, Kingsbury Drive, Bundoora, Victoria 3086, Australia
    Cell Death Differ 21:1600-12. 2014
    Both receptor-interacting protein kinase 1 (RIPK1) and RIPK3 can signal cell death following death receptor ligation...
  50. ncbi Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP
    Guozhi Zhu
    Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Curr Biol 17:1438-43. 2007
    ..K)63-linked but not K48-linked polyubiquitin (polyUb) chains, and the ability of NEMO to bind to K63-linked polyUb RIP (receptor-interacting protein) is necessary for efficient tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB ..
  51. pmc Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1
    Chenyang Zhao
    Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195
    J Immunol 193:879-88. 2014
    ....
  52. doi Programmed necrosis and necroptosis signalling
    Maria Feoktistova
    Section of Molecular Dermatology, Department of Dermatology, Venereology and Allergology, Medical Faculty Mannheim, University Heidelberg, Germany
    FEBS J 282:19-31. 2015
    ..The central roles of receptor-interacting serine/threonine protein kinase1 (RIPK1), RIPK3, and mixed-lineage kinase domain-like protein, and the molecular signalling platforms in which these ..
  53. pmc RIP3 induces apoptosis independent of pronecrotic kinase activity
    Pratyusha Mandal
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 56:481-95. 2014
    ..These compounds interact with RIP3 to activate caspase 8 (Casp8) via RHIM-driven recruitment of RIP1 (RIPK1) to assemble a Casp8-FADD-cFLIP complex completely independent of pronecrotic kinase activities and MLKL...
  54. doi Upregulated RIP3 Expression Potentiates MLKL Phosphorylation-Mediated Programmed Necrosis in Toxic Epidermal Necrolysis
    Sue Kyung Kim
    Department of Dermatology, Ajou University School of Medicine, Suwon, Korea
    J Invest Dermatol 135:2021-30. 2015
    ..Results from this study suggest that the high expression of RIP3 in keratinocytes from TEN patients potentiates MLKL phosphorylation/activation and necrotic cell death. Thus, RIP3 represents a potential target for treatment of TEN. ..
  55. pmc A Role for Tubular Necroptosis in Cisplatin-Induced AKI
    Yanfang Xu
    Department of Nephrology, First Affiliated Hospital, Fujian Medical University, Fuzhou, China State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China Department of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Chinese PLA General Hospital, Beijing, China
    J Am Soc Nephrol 26:2647-58. 2015
    ..We found that inhibition of any of the core components of the necroptotic pathway-receptor-interacting protein 1 (RIP1), RIP3, or mixed lineage kinase domain-like protein (MLKL)-by gene knockout or a chemical inhibitor diminished ..
  56. pmc RIP1 negatively regulates basal autophagic flux through TFEB to control sensitivity to apoptosis
    Tohru Yonekawa
    Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA
    EMBO Rep 16:700-8. 2015
    In a synthetic lethality/viability screen, we identified the serine-threonine kinase RIP1 (RIPK1) as a gene whose knockdown is highly selected against during growth in normal media, in which autophagy is not critical, but selected for in ..
  57. pmc Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide
    Hong Bing Yu
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    J Biol Chem 284:36007-11. 2009
    ..demonstrated that IDR-1 enhanced the tumor necrosis factor alpha-induced p62 receptor-interacting protein 1 (RIP1) complex formation but did not affect tumor necrosis factor alpha-induced p62-protein kinase zeta complex formation...
  58. doi The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal
    Lieselotte Vande Walle
    VIB, Department for Molecular Biomedical Research, B 9052 Zwijnaarde, Belgium
    Cell Res 20:421-33. 2010
    ..Accordingly, recombinant HtrA2/Omi efficiently cleaved mouse RIP1 in vitro, generating fragments matching those observed in IL-3-deprived Ba/F3 cells...
  59. pmc Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme
    Timothy T Lu
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0451, USA
    Immunity 38:896-905. 2013
    ..A20's C103 deubiquitinating motif restricted both K48- and K63-linked ubiquitination of receptor interacting protein 1 (RIP1). A20's ZF4 was required for recruiting A20 to ubiquitinated RIP1...
  60. pmc Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis
    Colleen R McNamara
    Graduate Program in Biochemistry, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachussets, United States of America
    PLoS ONE 8:e56576. 2013
    ..we investigated the signaling mechanisms controlled by the necroptosis mediator receptor interacting protein-1 (RIP1) kinase...
  61. doi Palmitate induces RIP1-dependent necrosis in RAW 264.7 cells
    Seong Keun Kim
    Institute of Hansen s Disease, South Korea
    Atherosclerosis 225:315-21. 2012
    ..The possible involvement of RIP1 in palmitate-induced macrophage death and its underlying molecular mechanism was investigated in this study.
  62. pmc The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida, USA
    Nat Immunol 12:834-43. 2011
    ..IKKα therefore serves a key role in the negative feedback of NF-κB canonical signaling by orchestrating assembly of the A20 ubiquitin-editing complex to limit inflammatory gene activation...
  63. pmc Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation
    Hidekatsu Iha
    Laboratory of Molecular Microbiology, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    EMBO J 27:629-41. 2008
    ..TAX1BP1-/- cells are more highly activated for NF-kappaB than control cells when stimulated with TNF-alpha or IL-1beta. Mechanistically, TAX1BP1 acts in NF-kappaB signalling as an essential adaptor between A20 and its targets...
  64. doi TNFα induced noncanonical NF-κB activation is attenuated by RIP1 through stabilization of TRAF2
    Joo Young Kim
    Institute for Medical Sciences, Ajou University School of Medicine, Suwon, 443 749, Korea
    J Cell Sci 124:647-56. 2011
    ..Although a crucial role of RIP1 in the TNFα-induced canonical NF-κB pathway has been well established, its involvement in noncanonical activation ..
  65. doi Critical contribution of oxidative stress to TNFα-induced necroptosis downstream of RIPK1 activation
    Ryodai Shindo
    Department of Immunology, Biomedical Research Center, Juntendo University Graduate School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 436:212-6. 2013
    ..b>RIPK1 is activated through oligomerization of upstream adaptor molecules such as Fas-associated protein with death ..
  66. pmc Protease activity of procaspase-8 is essential for cell survival by inhibiting both apoptotic and nonapoptotic cell death dependent on receptor-interacting protein kinase 1 (RIP1) and RIP3
    Mina Kikuchi
    Laboratory of Molecular and Cellular Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 287:41165-73. 2012
    ..Further analysis indicated that RIP1 and RIP3 regulate this multiple cell death, because the cell death as well as ROS production was completely ..
  67. doi RIP1-mediated mitochondrial dysfunction and ROS production contributed to tumor necrosis factor alpha-induced L929 cell necroptosis and autophagy
    Yuan Chao Ye
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China
    Int Immunopharmacol 14:674-82. 2012
    ..Notably, the RIP1 (serine-threonine kinase receptor-interacting protein 1, a main adaptor protein of necroptosis) specific inhibitor ..
  68. pmc The prevalence of TNFα-induced necrosis over apoptosis is determined by TAK1-RIP1 interplay
    Seda Çöl Arslan
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 6:e26069. 2011
    ..Here, we show that in cells lacking TGFβ-activated Kinase-1 (TAK1) expression, catalytically active Receptor Interacting Protein 1 (RIP1)-dependent programmed necrosis overrides apoptotic processes following Tumor Necrosis Factor-α (..
  69. pmc Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia
    R Chavez-Valdez
    Department of Pediatrics, Division of Neonatology, Johns Hopkins Medical Institutions, Johns Hopkins Hospital, 600 N Wolfe Street, CMSC 6 104, Baltimore, MD 21287, USA
    Neuroscience 219:192-203. 2012
    Receptor interacting protein (RIP)-1 kinase activity mediates a novel pathway that signals for regulated necrosis, a form of cell death prominent in traumatic and ischemic brain injury...
  70. doi Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo
    Martinus I F J Oerlemans
    Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Basic Res Cardiol 107:270. 2012
    ..Necrostatin-1 (Nec-1), a small molecule capable of inhibiting a key regulator of programmed necrosis (RIP1), was shown to prevent necrotic cell death in experimental models including cardiac ischemia...
  71. doi The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity
    Rune Busk Damgaard
    Department of Disease Biology, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, 2200 Copenhagen, Denmark
    Mol Cell 46:746-58. 2012
    ..We conclude that XIAP and LUBAC constitute essential ubiquitin ligases in NOD2-mediated inflammatory signaling and propose that deregulation of NOD2 signaling contributes to XLP-2 pathogenesis...
  72. pmc Sam68 is required for both NF-κB activation and apoptosis signaling by the TNF receptor
    Parameswaran Ramakrishnan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Mol Cell 43:167-79. 2011
    ..We found that Sam68 is recruited to the TNF receptor, and its deficiency dramatically reduces RIP recruitment and ubiquitylation...
  73. pmc Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
    Edward S Mocarski
    Department of Microbiology and Immunology, Emory Vaccine Center, 1462 Clifton Rd NE, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Rev Immunol 12:79-88. 2011
    ..and the necrotic cell death pathway that is dependent on receptor-interacting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3)...
  74. pmc The death domain-containing kinase RIP1 regulates p27(Kip1) levels through the PI3K-Akt-forkhead pathway
    Seongmi Park
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8813, USA
    EMBO Rep 9:766-73. 2008
    ..Here, we show that the receptor-interacting protein 1 (RIP1)-an essential mediator of inflammation-induced nuclear factor-kappaB (NF-kappaB) activation-regulates p27(Kip1) ..
  75. pmc Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice
    Jun Zhang
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:3042-9. 2006
    ..These results suggest that CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo...
  76. pmc Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production
    Mikyoung Chang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 10:1089-95. 2009
    ..Notably, Peli1 bound to and ubiquitinated RIP1, a signaling molecule that mediates IKK activation induced by the TLR3 and TLR4 adaptor TRIF...
  77. pmc DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
    Manuele Rebsamen
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    EMBO Rep 10:916-22. 2009
    ..show that these domains relay DAI-induced NF-kappaB signals through the recruitment of the RHIM-containing kinases RIP1 and RIP3. We show that knockdown of not only RIP1, but also RIP3 affects DAI-induced NF-kappaB activation...
  78. pmc c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation
    Eugene Varfolomeev
    Department of Protein Engineering, Genentech, Inc, South San Francisco, California 94080, USA
    J Biol Chem 283:24295-9. 2008
    ..of c-IAP1 or cells where the c-IAP proteins were eliminated using IAP antagonists, we show that TNFalpha-induced RIP1 ubiquitination is abrogated in the absence of c-IAPs...
  79. ncbi The tyrosine kinase Syk regulates TPL2 activation signals
    Aristides G Eliopoulos
    Laboratory of Molecular and Cellular Biology, Division of Basic Sciences, the University of Crete Medical School, Heraklion 71003, Crete, Greece
    J Biol Chem 281:1371-80. 2006
    ..stimulates the JNK, ERK, and p38 mitogen-activated protein kinases and the NF-kappaB pathway by recruiting RIP1 and TRAF2 to the TNF receptor 1...
  80. pmc Cytomegalovirus M45 cell death suppression requires receptor-interacting protein (RIP) homotypic interaction motif (RHIM)-dependent interaction with RIP1
    Jason W Upton
    Department of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:16966-70. 2008
    ..Cell death suppression by M45 requires RIP homotypic interaction motif-dependent interaction with RIP1. This interaction also underlies the cell tropism role of M45 in preventing premature death of endothelial cells ..
  81. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
    ..however, little is known about the mechanisms of A20-mediated inactivation of signaling intermediates such as RIP1. Here we demonstrate that the regulatory molecule TAX1BP1 recruited the E3 ligase Itch to A20 via two 'PPXY' motifs...
  82. ncbi Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation
    Yong Lin
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:10822-8. 2004
    ..cells and found that tumor necrosis factor receptor (TNFR) I mediates TNF-induced necrotic cell death, and that RIP, FADD, and TRAF2 are critical components of the signaling cascade of this TNF-induced necrotic cell death...
  83. ncbi Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells
    Sabine Gröbner
    Institute of Medical Microbiology and Hygiene, University of Tubingen, Elfriede Aulhorn Str, 6, 72076, Tuebingen, Germany
    Apoptosis 12:1813-25. 2007
    ..We found that both cleaved caspase-8 and receptor interacting protein 1 (RIP1) were associated with the Fas-associated death domain (FADD) indicating the formation of an ..
  84. ncbi RIP1 links inflammatory and growth factor signaling pathways by regulating expression of the EGFR
    D B Ramnarain
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8813, USA
    Cell Death Differ 15:344-53. 2008
    ..In this study, we show that the receptor-interacting protein (RIP1), a critical mediator of inflammation and stress-induced NF-kappaB activation, regulates the expression of the ..
  85. ncbi The death domain kinase RIP has an important role in DNA damage-induced, p53-independent cell death
    Gang Min Hur
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:25011-7. 2006
    ..Here we report that the death domain kinase, RIP (receptor-interacting protein), is important for DNA damage-induced, p53-independent cell death...
  86. pmc Receptor-interacting protein shuttles between cell death and survival signaling pathways
    Pachiyappan Kamarajan
    Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    Mol Biol Cell 21:481-8. 2010
    ..matrix contacts-activates a CD95/Fas-mediated signaling pathway regulated by receptor-interacting protein (RIP), a kinase that shuttles between CD95/Fas-mediated cell death and integrin/focal adhesion kinase (FAK)-mediated ..
  87. pmc The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation
    Gang Min Hur
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    Genes Dev 17:873-82. 2003
    ..Here we report that the receptor interacting protein, RIP, is the IKK upstream component, essential for the activation of NF-kappaB by DNA damage...
  88. ncbi A FADD-dependent innate immune mechanism in mammalian cells
    Siddharth Balachandran
    Department of Microbiology and Immunology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Nature 432:401-5. 2004
    ..largely independent of Toll-like receptor 3 and the dsRNA-dependent kinase PKR, but seems to require receptor interacting protein 1 as well as Tank-binding kinase 1-mediated activation of the transcription factor IRF-3...
  89. ncbi TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis
    Liang Guo Xu
    Integrated Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Biol Chem 279:17278-82. 2004
    ..Our studies identified a novel TRAF family member that is involved in MEKK3 signaling and apoptosis...
  90. doi Annexin-1 interacts with NEMO and RIP1 to constitutively activate IKK complex and NF-κB: implication in breast cancer metastasis
    P Bist
    Department of Physiology and NUS Immunology Program, Inflammation and Cancer Lab, National University of Singapore
    Oncogene 30:3174-85. 2011
    ..Importantly, silencing of ANXA1 prevents the interaction of NEMO and RIP1, which indicates that ANXA1 is required for the recruitment of RIP1 to the IKK complex, which may be important for ..
  91. ncbi Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway
    M Melnick
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California 90089 0641, USA
    Anat Rec 262:318-30. 2001
    ..The results of these experiments indicate that the TNF/TNF-R1 signal transduction pathway plays an important role in balancing cell proliferation and apoptosis during SMG duct and presumptive acini formation...
  92. doi RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein
    Akhil Rajput
    Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Immunity 34:340-51. 2011
    ..transcription factor IRF3 by the ribonucleic acid sensor RIG-I was restricted by caspase-8-mediated cleavage of the RIP1 protein, which resulted in conversion of RIP1 from a signaling enhancer to a signaling inhibitor...
  93. pmc A cytosolic ATM/NEMO/RIP1 complex recruits TAK1 to mediate the NF-kappaB and p38 mitogen-activated protein kinase (MAPK)/MAPK-activated protein 2 responses to DNA damage
    Yibin Yang
    Departments of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 31:2774-86. 2011
    ..b>RIP1 has been implicated in this response and found to be modified in cells with damaged DNA; however, the nature of the ..
  94. pmc NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis
    Roshan J Thapa
    Immune Cell Development and Host Defense Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Mol Cell Biol 31:2934-46. 2011
    ..Here, we show that IFN-γ induces RIP1 kinase-dependent necroptosis in mammalian cells deficient in NF-κB signaling...
  95. ncbi The modular nature of apoptotic signaling proteins
    K Hofmann
    MEMOREC Stoffel GmbH, Koln, Germany
    Cell Mol Life Sci 55:1113-28. 1999
    ....
  96. ncbi Comparison of human chromosome 6p25 with mouse chromosome 13 reveals a greatly expanded ov-serpin gene repertoire in the mouse
    Dion Kaiserman
    Department of Biochemistry and Molecular Biology, Monash University, 3800, Australia
    Genomics 79:349-62. 2002
    ..Compared with human, this larger mouse serpin repertoire probably reflects the need to regulate a larger proteinase repertoire arising from differing evolutionary pressures on the reproductive and immune systems...

Research Grants1

  1. Nutrient Flavonoids and Lung Cancer Prevention
    Yong Lin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..