Retn

Summary

Gene Symbol: Retn
Description: resistin
Alias: ADSF, Fizz3, Rstn, Xcp4, resistin, adipose tissue-specific secretory factor, adipose-specific cysteine-rich secreted protein A12-alpha, cysteine-rich secreted protein FIZZ3, dominant inhibitory adipocyte-specific secretory factor, found in inflammatory zone 3
Species: mouse

Top Publications

  1. ncbi The potential role of resistin in atherogenesis
    Mary Susan Burnett
    Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, 108 Irving Street, N W, Room 217, Washington, DC 20010, USA
    Atherosclerosis 182:241-8. 2005
  2. ncbi Pref-1 and ADSF/resistin: two secreted factors inhibiting adipose tissue development
    J A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    Horm Metab Res 34:664-70. 2002
  3. ncbi Regulation of fasted blood glucose by resistin
    Ronadip R Banerjee
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Penn Diabetes Center, 611 CRB, 415 Curie Boulevard, Universityof Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 303:1195-8. 2004
  4. ncbi Disulfide-dependent multimeric assembly of resistin family hormones
    Saurabh D Patel
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Science 304:1154-8. 2004
  5. ncbi Abnormal glucose homeostasis due to chronic hyperresistinemia
    Shamina M Rangwala
    Department of Medicine, The Penn Diabetes Center, Philadelphia, Pennsylvania, USA
    Diabetes 53:1937-41. 2004
  6. ncbi Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting
    Michael W Rajala
    Department of Cell Biology and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 53:1671-9. 2004
  7. pmc Role of resistin in diet-induced hepatic insulin resistance
    Evan D Muse
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 114:232-9. 2004
  8. pmc Activation of SOCS-3 by resistin
    Claire M Steppan
    Pfizer Inc, PRGD, MS220 3145, Eastern Point Rd, Groton, CT 06340, USA
    Mol Cell Biol 25:1569-75. 2005
  9. ncbi Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action
    Christophe Graveleau
    Division of Endocrinology, Metabolism, and Diabetes, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:31679-85. 2005
  10. ncbi The hormone resistin links obesity to diabetes
    C M Steppan
    Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 409:307-12. 2001

Scientific Experts

Detail Information

Publications89

  1. ncbi The potential role of resistin in atherogenesis
    Mary Susan Burnett
    Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, 108 Irving Street, N W, Room 217, Washington, DC 20010, USA
    Atherosclerosis 182:241-8. 2005
    b>Resistin, an adipocyte-derived cytokine linked to insulin resistance and obesity, has recently been shown to activate endothelial cells (ECs)...
  2. ncbi Pref-1 and ADSF/resistin: two secreted factors inhibiting adipose tissue development
    J A Villena
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    Horm Metab Res 34:664-70. 2002
    ..ADSF/resistin is secreted by adipocytes and inhibits adipose cells differentiation in vitro...
  3. ncbi Regulation of fasted blood glucose by resistin
    Ronadip R Banerjee
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and The Penn Diabetes Center, 611 CRB, 415 Curie Boulevard, Universityof Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 303:1195-8. 2004
    ..Here we report that mice lacking the adipocyte hormone resistin exhibit low blood glucose levels after fasting, due to reduced hepatic glucose production...
  4. ncbi Disulfide-dependent multimeric assembly of resistin family hormones
    Saurabh D Patel
    Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Science 304:1154-8. 2004
    b>Resistin, founding member of the resistin-like molecule (RELM) hormone family, is secreted selectively from adipocytes and induces liver-specific antagonism of insulin action, thus providing a potential molecular link between obesity and ..
  5. ncbi Abnormal glucose homeostasis due to chronic hyperresistinemia
    Shamina M Rangwala
    Department of Medicine, The Penn Diabetes Center, Philadelphia, Pennsylvania, USA
    Diabetes 53:1937-41. 2004
    b>Resistin is an adipocyte-secreted protein that circulates at increased levels in obesity. Acute administration of resistin impairs glucose tolerance, but the effects of chronic hyperresistinemia have not been established...
  6. ncbi Regulation of resistin expression and circulating levels in obesity, diabetes, and fasting
    Michael W Rajala
    Department of Cell Biology and Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Diabetes 53:1671-9. 2004
    b>Resistin was originally reported as an adipose tissue-specific hormone that provided a link between obesity and diabetes. Resistin protein level was elevated in obese mice and decreased by insulin-sensitizing thiazolidinediones...
  7. pmc Role of resistin in diet-induced hepatic insulin resistance
    Evan D Muse
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 114:232-9. 2004
    b>Resistin is an adipose-derived hormone postulated to link adiposity to insulin resistance...
  8. pmc Activation of SOCS-3 by resistin
    Claire M Steppan
    Pfizer Inc, PRGD, MS220 3145, Eastern Point Rd, Groton, CT 06340, USA
    Mol Cell Biol 25:1569-75. 2005
    b>Resistin is an adipocyte hormone that modulates glucose homeostasis...
  9. ncbi Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological action
    Christophe Graveleau
    Division of Endocrinology, Metabolism, and Diabetes, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 280:31679-85. 2005
    The adipocytokine resistin impairs glucose tolerance and insulin sensitivity in rodents. Here, we examined the effect of resistin on glucose uptake in isolated adult mouse cardiomyocytes...
  10. ncbi The hormone resistin links obesity to diabetes
    C M Steppan
    Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 409:307-12. 2001
    ..Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin)...
  11. ncbi Loss of resistin improves glucose homeostasis in leptin deficiency
    Yong Qi
    University of Pennsylvania School of Medicine, Division of Endocrinology, DiabetesMetabolism, 764 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Diabetes 55:3083-90. 2006
    b>Resistin levels are increased in obesity, and hyperresistinemia impairs glucose homeostasis in rodents...
  12. ncbi Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3
    Russell Brown
    Department of Obstetrics, Faculty of Medicine, Dalhousie University, Halifax, N S, Canada
    Neuroendocrinology 85:232-41. 2007
    Adipokines such as leptin, resistin, and fasting-induced adipose factor (FIAF) are secreted by adipocytes, but their expression is also detectable in the brain and pituitary...
  13. ncbi Resistin is a key mediator of glucose-dependent insulinotropic polypeptide (GIP) stimulation of lipoprotein lipase (LPL) activity in adipocytes
    Su Jin Kim
    Department of Cellular and Physiological Sciences and the Diabetes Research Group, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada
    J Biol Chem 282:34139-47. 2007
    ..of an intermediary molecule, and the current studies focused on the possible contribution of the adipokine resistin. In differentiated 3T3-L1 adipocytes, GIP, in the presence of insulin, increased resistin secretion through a ..
  14. doi Homocysteine upregulates resistin production from adipocytes in vivo and in vitro
    Yin Li
    Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, China
    Diabetes 57:817-27. 2008
    ..b>Resistin acts as a critical mediator of insulin resistance associated with inflammatory conditions...
  15. pmc Adipocyte-specific expression of murine resistin is mediated by synergism between peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins
    Takuya Tomaru
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6149, USA
    J Biol Chem 284:6116-25. 2009
    b>Resistin antagonizes insulin action in mouse, making it a potential therapeutic target for treating metabolic diseases such as diabetes...
  16. pmc Endoplasmic reticulum stress regulates adipocyte resistin expression
    Martina I Lefterova
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
    Diabetes 58:1879-86. 2009
    b>Resistin is a secreted polypeptide that impairs glucose metabolism and, in rodents, is derived exclusively from adipocytes...
  17. pmc Human resistin: found in translation from mouse to man
    Daniel R Schwartz
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Endocrinol Metab 22:259-65. 2011
    The discovery of resistin 10 years ago as a fat cell-secreted factor that modulates insulin resistance suggested a link to the current obesity-associated epidemics of diabetes and cardiovascular disease, which are major human health ..
  18. ncbi Cell type-specific expression and coregulation of murine resistin and resistin-like molecule-alpha in adipose tissue
    Michael W Rajala
    Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Endocrinol 16:1920-30. 2002
    ..b>Resistin, a 10-kDa adipose tissue specific secretory protein, has recently been implicated in exerting a negative effect ..
  19. ncbi Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells
    Nobuhiro Shojima
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Diabetes 51:1737-44. 2002
    b>Resistin is a hormone secreted by adipocytes that acts on skeletal muscle myocytes, hepatocytes, and adipocytes themselves, reducing their sensitivity to insulin...
  20. ncbi Mechanisms regulating adipocyte expression of resistin
    Helen B Hartman
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and Genetics and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:19754-61. 2002
    Resistin, also known as Adipocyte Secreted Factor (ADSF) and Found in Inflammatory Zone 3 (FIZZ3), is a mouse protein with potential roles in insulin resistance and adipocyte differentiation...
  21. ncbi Increased expression of the adipokine genes resistin and fasting-induced adipose factor in hypoxic/ischaemic mouse brain
    Glen Wiesner
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroreport 17:1195-8. 2006
    Adipose tissue is the primary source of the adipokines resistin and fasting-induced adipose factor (FIAF). We reported that the brain is also a site of adipokine expression, although their function there is unknown...
  22. pmc Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice
    Mohammed Qatanani
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6149, USA
    J Clin Invest 119:531-9. 2009
    b>Resistin is an adipokine that contributes to insulin resistance in mice. In humans, however, studies investigating the link between resistin and metabolic disease are conflicting...
  23. pmc Resistin deficiency in mice has no effect on pulmonary responses induced by acute ozone exposure
    Shehla S Razvi
    Division of Critical Care Medicine, Department of Pediatrics, The University of Texas Medical School at Houston, Houston, Texas
    Am J Physiol Lung Cell Mol Physiol 309:L1174-85. 2015
    ..Human resistin, a pleiotropic hormone and cytokine, induces expression of IL-1α, IL-1β, IL-6, IL-8 (the human ortholog of ..
  24. pmc Lymphotoxin-β receptor signaling through NF-κB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells
    Cécile Bénézech
    School of Immunity and Infection, IBR MRC Centre for Immune Regulation, College of Medical and Dental Sciences, University of Birmingham, UK
    Immunity 37:721-34. 2012
    ..Thus, we propose that adipose tissues act as a source of lymphoid stroma for lymph nodes and other lymphoid structures associated with fat...
  25. doi Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes
    An Yu
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    Mol Cell Endocrinol 377:23-32. 2013
    b>Resistin is a cysteine-rich secreted protein which significantly inhibits phosphorylation of AMP-activated protein kinase in both human and mouse hepatocytes...
  26. doi Resistin affects lipid metabolism during adipocyte maturation of 3T3-L1 cells
    Yoshito Ikeda
    Department of Biophysical Chemistry, Kyoto Pharmaceutical University, Japan
    FEBS J 280:5884-95. 2013
    b>Resistin, an adipose-tissue-specific secretory factor, aggravates metabolic syndrome through impairment of glucose metabolism...
  27. pmc Adenylyl cyclase-associated protein 1 is a receptor for human resistin and mediates inflammatory actions of human monocytes
    Sahmin Lee
    Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak Ro, Jongno gu, Seoul 110 744, Korea Department of Molecular Medicine and Biopharmaceutical Science, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, 1 Gwanak ro, Gwanak Gu, Seoul 151 742, Korea
    Cell Metab 19:484-97. 2014
    Human resistin is a cytokine that induces low-grade inflammation by stimulating monocytes. Resistin-mediated chronic inflammation can lead to obesity, atherosclerosis, and other cardiometabolic diseases...
  28. doi Resistin regulates the expression of plasminogen activator inhibitor-1 in 3T3-L1 adipocytes
    Yoshito Ikeda
    Department of Biophysical Chemistry, Kyoto Pharmaceutical University, Kyoto 607 8414, Japan
    Biochem Biophys Res Commun 448:129-33. 2014
    b>Resistin and plasminogen activator inhibitor-1 (PAI-1) are adipokines, which are secreted from adipocytes...
  29. pmc Antiresistin RNA Oligonucleotide Ameliorates Diet-Induced Nonalcoholic Fatty Liver Disease in Mice through Attenuating Proinflammatory Cytokines
    Yi Tan
    School of Medical and Molecular Biosciences, University of Technology Sydney, Sydney, NSW 2007, Australia
    Biomed Res Int 2015:414860. 2015
    The aim of this study was to determine whether inhibition of resistin by a synthetic antiresistin RNA (oligonucleotide) oligo ameliorates metabolic and histological abnormalities in nonalcoholic fatty liver disease (NAFLD) induced by high-..
  30. doi Short-term Regulation of Resistin in vivo by Oral Lipid Ingestion and in vitro by Fatty Acid Stimulation
    A Schmid
    Department of Internal Medicine III, Giessen University Hospital, Germany
    Exp Clin Endocrinol Diabetes 123:553-60. 2015
    ..We investigated pro-inflammatory resistin and anti-inflammatory adiponectin regulation during oral lipid ingestion (OLI) in healthy adults...
  31. doi An isoform of decorin is a resistin receptor on the surface of adipose progenitor cells
    Alexes C Daquinag
    The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, The University of Texas Health Science Center at Houston, TX 77030, USA
    Cell Stem Cell 9:74-86. 2011
    ..In a screen for ΔDCN-binding proteins, we identified resistin, an adipokine for which the receptor has been unknown...
  32. doi Interaction between resistin and adiponectin in the proliferation of rat vascular smooth muscle cells
    Hiroyuki Hirai
    Department of Nephrology, Fukushima Medical University, 1 Hikarigaoka, Fukushima City, Fukushima 960 1295, Japan
    Mol Cell Endocrinol 366:108-16. 2013
    We investigated the effect between resistin and adiponectin on the proliferation of vascular smooth muscle cells (VSMCs)...
  33. pmc Alterations in mouse hypothalamic adipokine gene expression and leptin signaling following chronic spinal cord injury and with advanced age
    Gregory E Bigford
    The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 7:e41073. 2012
    ..We demonstrate significant changes in fasting-induced adipose factor (FIAF), resistin (Rstn), long-form leptin receptor (LepRb) and suppressor of cytokine-3 (SOCS3) gene expression following chronic ..
  34. doi Mouse resistin modulates adipogenesis and glucose uptake in 3T3-L1 preadipocytes through the ROR1 receptor
    Beatriz Sánchez-Solana
    Laboratory of Biochemistry and Molecular Biology, Department of Inorganic and Organic Chemistry and Biochemistry, Medical School Regional Center for Biomedical Research, University of Castilla La Mancha, 02006 Albacete, Spain
    Mol Endocrinol 26:110-27. 2012
    Mouse resistin, a cysteine-rich protein primarily secreted from mature adipocytes, is involved in insulin resistance and type 2 diabetes...
  35. pmc Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling
    Zhikui Wei
    Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 286:15652-65. 2011
    ..These results provide the first functional characterization of CTRP13 and establish its importance in glucose homeostasis...
  36. pmc Age-related autocrine diabetogenic effects of transgenic resistin in spontaneously hypertensive rats: gene expression profile analysis
    Michal Pravenec
    Institute of Physiology, Czech Academy of Sciences, 14220 Prague 4, Czech Republic
    Physiol Genomics 43:372-9. 2011
    Increased circulating levels of resistin have been proposed as a possible link between obesity and insulin resistance; however, many of the potential metabolic effects of resistin remain to be investigated, including systemic versus local ..
  37. pmc Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1)
    Kichoon Lee
    Department of Nutritional Sciences and Toxicology, and Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    J Clin Invest 111:453-61. 2003
    ..These findings demonstrate the inhibition of adipogenesis by Pref-1 in vivo and the resulting impairment of adipocyte function that leads to the development of metabolic abnormalities...
  38. ncbi Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules
    Haiyan Song
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113, Tokyo, Japan
    Biochem Biophys Res Commun 299:291-8. 2002
    Expression of the adipocyte-derived protein resistin, which is thought to play a key role in the development of insulin resistance in vivo, is regulated by a variety of hormones and mediators, including insulin and TNFalpha...
  39. pmc Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity
    Chloe C Feral
    Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Diabetes 57:1842-51. 2008
    ..Thus, we hypothesized that mice bearing an alpha4(Y991A) mutation, which blocks signaling, would be protected from development of high-fat diet-induced insulin resistance...
  40. doi Induction of angiogenesis by murine resistin: putative role of PI3-kinase and NO-dependent pathways
    Stephanie A Robertson
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, UK
    Regul Pept 152:41-7. 2009
    ..Obesity results in dysregulated adipokine secretion, contributing to pathophysiologies associated with this disorder, including insulin resistance and cardiovascular disease...
  41. ncbi A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation
    K H Kim
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Biol Chem 276:11252-6. 2001
    A 12.5-kDa cysteine-rich adipose tissue-specific secretory factor (ADSF/resistin) is a novel secreted protein rich in serine and cysteine residues with a unique cysteine repeat motif of CX(12)CX(8)CXCX(3)CX(10)CXCXCX(9)CC. A single 0...
  42. ncbi Effect of metformin on adipose tissue resistin expression in db/db mice
    Hiroki Fujita
    Department of Geriatric Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Biochem Biophys Res Commun 298:345-9. 2002
    b>Resistin, a novel adipose-derived protein, has been proposed to cause insulin-resistant states in obesity...
  43. doi Oligomeric resistin impairs insulin and AICAR-stimulated glucose uptake in mouse skeletal muscle by inhibiting GLUT4 translocation
    Sebastian Beck Jørgensen
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia
    Am J Physiol Endocrinol Metab 297:E57-66. 2009
    The hormone resistin is elevated in obesity and impairs glucose homeostasis. Here, we examined the effect of oligomerized human resistin on insulin signaling and glucose metabolism in skeletal muscle and myotubes...
  44. pmc A family of tissue-specific resistin-like molecules
    C M Steppan
    Division of Endocrinology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:502-6. 2001
    We have identified a family of resistin-like molecules (RELMs) in rodents and humans. Resistin is a hormone produced by fat cells...
  45. doi Resistin differentially modulates neuropeptide gene expression and AMP-activated protein kinase activity in N-1 hypothalamic neurons
    Russell E Brown
    Department of Obstetrics and Gynaecology, Dalhousie University, IWK Health Centre, 5850 5980 University Avenue, PO Box 9700, Halifax, Nova Scotia B3K 6R8, Canada
    Brain Res 1294:52-60. 2009
    Intraventricular resistin is known to reduce food intake, modify hypothalamic gene expression (e.g. NPY, POMC) and influence the activity of novel metabolic enzymes (e.g. 5'AMP-activated protein kinase; AMPK) in the rodent brain...
  46. doi Resistin up-regulates COX-2 expression via TAK1-IKK-NF-kappaB signaling pathway
    Jian Zhang
    Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    Inflammation 33:25-33. 2010
    The hormone resistin, which was originally shown to induce insulin resistance, has been implicated in the regulation of inflammatory processes, but the molecular mechanism underlying such regulation has not been clearly defined...
  47. doi Tissue-specific effects of valsartan on rstn and fiaf gene expression in the ob/ob mouse
    S A Imran
    Division of Endocrinology, Dalhousie University, 1278 Tower Road, Halifax, NS, Canada
    Diab Vasc Dis Res 7:231-8. 2010
    ..We studied the effect of valsartan on adipokine genes resistin (rstn) and fasting-induced adipose factor (fiaf) using obese and diabetic ob/ob mice...
  48. doi S-resistin inhibits adipocyte differentiation and increases TNFalpha expression and secretion in 3T3-L1 cells
    Carmen M Fernández
    Centro Regional de Investigaciones Biomédicas, Universidad de Castilla La Mancha, Toledo, Spain
    Biochim Biophys Acta 1803:1131-41. 2010
    S-resistin is a non-secretable resistin spliced variant described in white adipose tissue from Wistar rats...
  49. pmc Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice
    Hyeong Kyu Park
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine and Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 60:775-83. 2011
    Although adipocyte-derived murine resistin links insulin resistance to obesity, the role of human resistin, predominantly expressed in mononuclear cells and induced by inflammatory signals, remains unclear...
  50. ncbi Leptin treatment markedly increased plasma adiponectin but barely decreased plasma resistin of ob/ob mice
    Marie Laure Delporte
    Endocrinology et Metabolism Unit, Univeristy of Louvain, Faculty of Medicine, Brussels, Belgium
    Am J Physiol Endocrinol Metab 287:E446-53. 2004
    ..We also briefly tackled the influence of this treatment on resistin, another adipocytokine involved in obesity-related insulin resistance...
  51. pmc FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family
    I N Holcomb
    Department of Pathology, Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    EMBO J 19:4046-55. 2000
    ..In vivo, FIZZ1 may modulate the function of neurons innervating the bronchial tree, thereby altering the local tissue response to allergic pulmonary inflammation...
  52. ncbi Pituitary resistin gene expression: effects of age, gender and obesity
    Barbara A Morash
    Department of Obstetrics and Gynaecology, Division of Endocrinology and Metabolism, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroendocrinology 79:149-56. 2004
    b>Resistin is a new adipocytokine which is expressed in rat, mouse and possibly human adipose tissue. Its putative role as a mediator of insulin resistance is controversial...
  53. pmc Dominant inhibitory adipocyte-specific secretory factor (ADSF)/resistin enhances adipogenesis and improves insulin sensitivity
    Kee Hong Kim
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:6780-5. 2004
    Adipocyte-specific secretory factor (ADSF)/resistin is a small cysteine-rich protein secreted from adipose tissue that belongs to a gene family found in inflammatory zone (FIZZ) or found in resistin-like molecule (RELM)...
  54. ncbi Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin
    Say Viengchareun
    INSERM U478, Institut Fédératif de Recherche Claude Bernard, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75018, Paris, France
    FEBS Lett 532:345-50. 2002
    Adiponectin and resistin, two recently identified adipocyte-specific secretory factors, are able to modulate insulin actions in target tissues...
  55. ncbi Changes in glycemia by leptin administration or high- fat feeding in rodent models of obesity/type 2 diabetes suggest a link between resistin expression and control of glucose homeostasis
    Cedric Asensio
    Department of Cell Physiology and Metabolism, University Medical Center, University of Geneva, 1211 Geneva 4, Switzerland
    Endocrinology 145:2206-13. 2004
    b>Resistin is an adipose-derived hormone that has been proposed as a link among obesity, insulin resistance, and diabetes...
  56. ncbi Resistin: molecular history and prognosis
    Ronadip R Banerjee
    Division of Endocrinology, Diabetes, and Metabolism, Penn Diabetes Center, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104 6149, USA
    J Mol Med (Berl) 81:218-26. 2003
    ..Here we consider a novel secreted factor first identified as a TZD-suppressible gene in mouse adipocytes, called resistin, and discuss what is currently known about resistin regulation and function in mouse and human.
  57. ncbi Intracerebroventricular administration of NPY stimulates resistin gene expression in mice
    Hideki Yuzuriha
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    Int J Mol Med 11:675-6. 2003
    b>Resistin is thought to cause insulin resistance and link obesity to type 2 diabetes mellitus. However, little is known about the effects of neuropeptide Y (NPY) on resistin gene expression in white adipose tissue (WAT)...
  58. ncbi Weight loss in tumour-bearing mice is not associated with changes in resistin gene expression in white adipose tissue
    J Gomez-Ambrosi
    Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, UK
    Horm Metab Res 34:674-7. 2002
    b>Resistin, a product of white adipose tissue, is postulated to induce insulin resistance in obesity and regulate adipocyte differentiation...
  59. ncbi Resistin inhibits glucose uptake in L6 cells independently of changes in insulin signaling and GLUT4 translocation
    Byoung Moon
    Diabetes Research Laboratory, Winthrop University Hospital, Mineola, New York 11501, USA
    Am J Physiol Endocrinol Metab 285:E106-15. 2003
    Elevated levels of resistin have been proposed to cause insulin resistance and therefore may serve as a link between obesity and type 2 diabetes. However, its role in skeletal muscle metabolism is unknown...
  60. ncbi Resistin down-regulates insulin receptor expression, and modulates cell viability in rodent pancreatic beta-cells
    James E P Brown
    Diabetes and Metabolic Disorders Research Group, Research Institute in Healthcare Sciences, University of Wolverhampton, Wolverhampton, UK
    FEBS Lett 581:3273-6. 2007
    The adipokine resistin is known to induce insulin resistance in rodent tissues. Increases in adipose tissue mass are known to have a negative effect on pancreatic beta-cell function, although the mechanisms are poorly understood...
  61. ncbi Resistin/ADSF/FIZZ3 in obesity and diabetes
    Hei Sook Sul
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA
    Trends Endocrinol Metab 15:247-9. 2004
    The role of adipocyte-secreted resistin/adipocyte-specific secretory factor (ADSF)/FIZZ3 in obesity and diabetes has been controversial at best...
  62. ncbi Inhibitory effect of green tea (-)-epigallocatechin gallate on resistin gene expression in 3T3-L1 adipocytes depends on the ERK pathway
    Hang Seng Liu
    Department of General Medical Laboratory, Armed Forces Tao Yuan General Hospital, Chung Li City, Tao Yuan, Taiwan
    Am J Physiol Endocrinol Metab 290:E273-81. 2006
    b>Resistin (Rstn) is known as an adipocyte-specific secretory hormone that can cause insulin resistance and decrease adipocyte differentiation...
  63. ncbi Endothelin-1 inhibits resistin secretion in 3T3-L1 adipocytes
    Qiao Zhong
    Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, 219 Greene Hall, Auburn, AL 36849 5518, USA
    Biochem Biophys Res Commun 296:383-7. 2002
    b>Resistin is an adipocyte-derived hormone whose role in the development of insulin resistance is controversial...
  64. pmc Adenovirus-mediated chronic "hyper-resistinemia" leads to in vivo insulin resistance in normal rats
    Hiroaki Satoh
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla 92093 0673, USA
    J Clin Invest 114:224-31. 2004
    We investigated the chronic in vivo effect of resistin on insulin sensitivity and glucose metabolism by overexpressing resistin protein in male Wistar rats using intravenous administration of an adenovirus encoding mouse resistin...
  65. ncbi Sp1 mediates repression of the resistin gene by PPARgamma agonists in 3T3-L1 adipocytes
    S S Chung
    Genome Research Center for Diabetes and Endocrine Disease, Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
    Biochem Biophys Res Commun 348:253-8. 2006
    b>Resistin is an adipokine related to obesity and insulin resistance. Expression of the resistin gene is repressed by the treatment of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, thiazolidinediones (TZDs)...
  66. ncbi Resistin expression and regulation in mouse pituitary
    Barbara A Morash
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Dalhousie University, 5980 University Avenue, Halifax, NS, Canada B3J 3G9
    FEBS Lett 526:26-30. 2002
    b>Resistin, a new adipocytokine, is expressed in human, rat and mouse adipose tissue. Its putative role as a mediator of insulin resistance is controversial...
  67. pmc A novel role for Oct-2 in the lipopolysaccharide-mediated induction of resistin gene expression in RAW264.7 cells
    Shao Chun Lu
    Department of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
    Biochem J 402:387-95. 2007
    Although resistin was first suggested as a possible link between obesity and diabetes, we have demonstrated previously that expression of resistin is induced by LPS (lipopolysaccharide)...
  68. ncbi Resistin induces insulin resistance in pancreatic islets to impair glucose-induced insulin release
    Masanori Nakata
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Biochem Biophys Res Commun 353:1046-51. 2007
    An adipokine resistin, a small cysteine-rich protein, is one of the major risk factors of insulin resistance...
  69. ncbi A gene-driven approach to the identification of ENU mutants in the mouse
    Emma L Coghill
    MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell OX11 ORD, UK
    Nat Genet 30:255-6. 2002
    ..We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program...
  70. pmc Endocrine regulation of energy metabolism by the skeleton
    Na Kyung Lee
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Cell 130:456-69. 2007
    ..By revealing that the skeleton exerts an endocrine regulation of sugar homeostasis this study expands the biological importance of this organ and our understanding of energy metabolism...
  71. ncbi Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes
    M Fasshauer
    Department of Internal Medicine III, University of Leipzig, Leipzig, 04103, Germany
    Biochem Biophys Res Commun 288:1027-31. 2001
    b>Resistin has recently been implicated as an adipocytokine leading to insulin resistance and, therefore, potentially linking obesity and diabetes...
  72. pmc Resistin, an adipocytokine, offers protection against acute myocardial infarction
    Jinping Gao
    Cecile Cox Quillen Laboratory of Geriatrics, James H Quillen College of Medicine East Tennessee State University, and James H Quillen Veterans Affairs Medical Center, Johnson City, TN 37614, USA
    J Mol Cell Cardiol 43:601-9. 2007
    b>Resistin, an adipocyte-derived hormone, is thought to represent a link between obesity and insulin-resistant diabetes. The potential role of resistin as a cardioprotective agent has not been explored...
  73. pmc A paradox: insulin inhibits expression and secretion of resistin which induces insulin resistance
    Feng Liu
    Institute of Pediatrics of Nanjing Maternity and Child Health Hospital of the Nanjing Medical University, Nanjing 210004, Jiangsu Province, China
    World J Gastroenterol 14:95-100. 2008
    To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro.
  74. ncbi Dimerization of resistin and resistin-like molecules is determined by a single cysteine
    R R Banerjee
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 276:25970-3. 2001
    b>Resistin is a peptide hormone secreted by adipocytes. Cysteine residues comprise 11 of 94 (12%) amino acids in resistin...
  75. ncbi IGF-I downregulates resistin gene expression and protein secretion
    Yen Hang Chen
    Department of Life Science, College of Science, National Central University, Chung Li City, Taoyuan, Taiwan
    Am J Physiol Endocrinol Metab 288:E1019-27. 2005
    b>Resistin (Rstn) is known as an adipocyte-specific secretory factor that can cause insulin resistance and decrease adipocyte differentiation...
  76. ncbi Impaired glucose tolerance is accompanied by decreased insulin sensitivity in tissues of mice implanted with cells that overexpress resistin
    Y Kitagawa
    Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Diabetologia 47:1847-53. 2004
    b>Resistin, the expression of which is suppressed by thiazolidinedione treatment in adipocytes, is one of the key molecules for the tight link between adiposity and insulin resistance...
  77. ncbi The physiological role of resistin and its connection with metabolic diseases
    K Motojima
    Department of Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    J Endocrinol Invest 26:1171-3. 2003
  78. ncbi Sexual dimorphism and regulation of resistin, adiponectin, and leptin expression in the mouse
    Yaoting Gui
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    Obes Res 12:1481-91. 2004
    To examine gender differences and hormonal regulation of resistin, adiponectin, and leptin.
  79. doi Octylphenol stimulates resistin gene expression in 3T3-L1 adipocytes via the estrogen receptor and extracellular signal-regulated kinase pathways
    Meng Jung Lee
    Department of Life Science, National Central University, Chung Li City, Taoyuan, Taiwan
    Am J Physiol Cell Physiol 294:C1542-51. 2008
    b>Resistin is known as an adipocyte-specific secretory hormone that can cause insulin resistance and decrease adipocyte differentiation. It can be regulated by sexual hormones...
  80. ncbi Identification of murine and human XCP1 genes as C/EBP-epsilon-dependent members of FIZZ/Resistin gene family
    Alexey M Chumakov
    Cedars Sinai Medical Center, Burns and Allen Research Institute, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Oncogene 23:3414-25. 2004
    ..mXCP1 belongs to a family of XCP/FIZZ/Resistin genes, which includes four murine genes and two human genes, hXCP1 and hXCP2...
  81. ncbi Resistin and RELM-alpha gene expression in white adipose tissue of lactating mice
    Chen Bing
    Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Liverpool, UK
    Biochem Biophys Res Commun 296:458-62. 2002
    The adipose tissue-derived factor resistin has been suggested to induce insulin resistance in obesity and inhibit adipocyte differentiation...
  82. pmc Loss of resistin ameliorates hyperlipidemia and hepatic steatosis in leptin-deficient mice
    Neel S Singhal
    Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Physiol Endocrinol Metab 295:E331-8. 2008
    b>Resistin has been linked to components of the metabolic syndrome, including obesity, insulin resistance, and hyperlipidemia. We hypothesized that resistin deficiency would reverse hyperlipidemia in genetic obesity...
  83. doi Involvement of iNOS and NO in TNF-alpha-downregulated resistin gene expression in 3T3-L1 adipocytes
    Chi Chang Juan
    Department of Physiology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Obesity (Silver Spring) 16:1219-25. 2008
    In order to characterize the regulation of resistin gene expression, we explore the effect of tumornecrosis factor-alpha (TNF-alpha) on resistin mRNA expression and its underlying mechanism in 3T3-L1 adipocytes.
  84. ncbi Expression and regulation of resistin in osteoblasts and osteoclasts indicate a role in bone metabolism
    Liv Thommesen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    J Cell Biochem 99:824-34. 2006
    ..secretion of a range of biologically active proteins, called adipokines, for example, leptin, adiponectin, and resistin. Leptin has previously been shown to be expressed in osteoblasts and to promote bone mineralization, whereas ..
  85. ncbi Comparative studies of resistin expression and phylogenomics in human and mouse
    Rong Ze Yang
    Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Biochem Biophys Res Commun 310:927-35. 2003
    b>Resistin is a newly identified adipocytokine that has been proposed to be a link between obesity and type 2 diabetes based on animal studies...
  86. pmc Local regulation of fat metabolism in peripheral nerves
    Mark H G Verheijen
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Genes Dev 17:2450-64. 2003
    ....
  87. ncbi Adenovirus-mediated high expression of resistin causes dyslipidemia in mice
    Naoichi Sato
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Endocrinology 146:273-9. 2005
    The adipocyte-derived hormone resistin has been proposed as a possible link between obesity and insulin resistance in murine models...
  88. ncbi Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid
    Fred Haugen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Lipid Res 46:143-53. 2005
    The resistin gene is expressed in adipocytes and encodes a protein proposed to link obesity and type 2 diabetes. Increased plasma FFA is associated with insulin resistance...