Rest

Summary

Gene Symbol: Rest
Description: RE1-silencing transcription factor
Alias: 2610008J04Rik, AA407358, NRSF, REST4, RE1-silencing transcription factor, neural-restrictive silencer factor
Species: mouse

Top Publications

  1. pmc REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells
    Helle F Jørgensen
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK
    Development 136:715-21. 2009
  2. pmc Reciprocal actions of REST and a microRNA promote neuronal identity
    Cecilia Conaco
    Department of Neurobiology and Behavior, Howard Hughes Medical Institute, State University of New York, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 103:2422-7. 2006
  3. ncbi Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Centre for Stem Cell Research, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    J Neurosci 27:6972-83. 2007
  4. doi REST is a key regulator in brain-specific homeobox gene expression during neuronal differentiation
    So Yun Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Korea
    J Neurochem 103:2565-74. 2007
  5. doi REST and its downstream molecule Mek5 regulate survival of primordial germ cells
    Daiji Okamura
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Dev Biol 372:190-202. 2012
  6. pmc SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation
    Thomas F Westbrook
    Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 452:370-4. 2008
  7. pmc REST maintains self-renewal and pluripotency of embryonic stem cells
    Sanjay K Singh
    Department of Cancer Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 453:223-7. 2008
  8. pmc DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome
    Claudia Canzonetta
    Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, UK
    Am J Hum Genet 83:388-400. 2008
  9. pmc REST regulates distinct transcriptional networks in embryonic and neural stem cells
    Rory Johnson
    Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore
    PLoS Biol 6:e256. 2008
  10. pmc A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome
    Alexander G Bassuk
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 83:572-81. 2008

Research Grants

Scientific Experts

  • Gail Mandel
  • Chun Sung Kim
  • David C Bersten
  • Masahito Shimojo
  • Thorsten R Doeppner
  • Sanjay K Singh
  • Noel J Buckley
  • Chai An Mao
  • Yuh Man Sun
  • Mei Qiang
  • Petra Lynen Jansen
  • T Edlund
  • Amanda G Fisher
  • Makoto Takano
  • Nurit Ballas
  • F S Jones
  • Chiara Soldati
  • Helle F Jørgensen
  • Joseph J Abrajano
  • Hitomi Aoki
  • Akira Hara
  • Angela Bithell
  • Yasuhiro Yamada
  • Lawrence W Stanton
  • Kee Yew Wong
  • Chiara Zuccato
  • Irfan A Qureshi
  • Aviv Bergman
  • Solen Gokhan
  • Mark F Mehler
  • Deyou Zheng
  • Shiran Naftelberg
  • Jing jing Liu
  • Elena Cattaneo
  • Zhilian Jia
  • Masahide Seki
  • Sebastian A Giusti
  • Francesca Cargnin
  • E Orta-Salazar
  • Takahiro Kunisada
  • Mei Yu
  • Francesco Paonessa
  • Caroline Johnston
  • Daiji Okamura
  • Andre J Faure
  • Nikolaj Dietrich
  • Matthew V Covey
  • Karen M J Van Loo
  • L Cai
  • Wei Wang
  • Zhengliang Gao
  • Yuichiro Hatano
  • Xiaojun Ren
  • Bushra Raj
  • Moumita Datta
  • Yan Zhang
  • Mei Lu
  • Jian Fei
  • Myriam Ravache
  • H Uchida
  • Ali C Ravanpay
  • Jun Kohyama
  • Xuhui Liu
  • Claudine L Bitel
  • Paola Conforti
  • Shailesh Kumar Gupta
  • Patrick A Schweizer
  • Matthias Merkenschlager
  • Aude Marie Lepagnol-Bestel
  • Gee Y Ching
  • Zhou Feng Chen
  • Thomas F Westbrook
  • Lichun Jiang
  • Rory Johnson
  • Claudia Canzonetta
  • Alexander G Bassuk
  • So Yun Park
  • Jaya Visvanathan
  • Deborah J Greenway
  • Shigeki Iwase
  • Cecilia Conaco
  • Marzia Tartari
  • Valérie Plaisance
  • Alexander W Bruce
  • Amar Abderrahmani
  • Nakatani Toshiyuki
  • Jacques Antoine Haefliger
  • Xiaohua Su
  • Gerard Waeber
  • Li Li

Detail Information

Publications90

  1. pmc REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells
    Helle F Jørgensen
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, London, UK
    Development 136:715-21. 2009
    b>REST is a transcriptional repressor that targets a group of neuronal genes in non-neuronal cells...
  2. pmc Reciprocal actions of REST and a microRNA promote neuronal identity
    Cecilia Conaco
    Department of Neurobiology and Behavior, Howard Hughes Medical Institute, State University of New York, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 103:2422-7. 2006
    ..The transcriptional repressor, RE1 silencing transcription factor (REST), has a reciprocal activity, inhibiting the expression of neuronal genes in nonneuronal cells...
  3. ncbi Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Centre for Stem Cell Research, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    J Neurosci 27:6972-83. 2007
    ..We now show that increased binding of the RE1 silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) repressor occurs at multiple genomic RE1/NRSE loci in ..
  4. doi REST is a key regulator in brain-specific homeobox gene expression during neuronal differentiation
    So Yun Park
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology KAIST, Daejeon, Korea
    J Neurochem 103:2565-74. 2007
    ..In this study, we show that binding of repressor element silencing transcription factor (REST) to the neuron restrictive silencer element (NRSE) represses Bsx transcription in non-neuronal P19 cells...
  5. doi REST and its downstream molecule Mek5 regulate survival of primordial germ cells
    Daiji Okamura
    Cell Resource Center for Biomedical Research, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Dev Biol 372:190-202. 2012
    ..Here, we found that REST (repressor element 1-silencing transcription factor), a transcription factor that binds a conserved regulatory ..
  6. pmc SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation
    Thomas F Westbrook
    Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 452:370-4. 2008
    The RE1-silencing transcription factor (REST, also known as NRSF) is a master repressor of neuronal gene expression and neuronal programmes in non-neuronal lineages...
  7. pmc REST maintains self-renewal and pluripotency of embryonic stem cells
    Sanjay K Singh
    Department of Cancer Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 453:223-7. 2008
    The neuronal repressor REST (RE1-silencing transcription factor; also called NRSF) is expressed at high levels in mouse embryonic stem (ES) cells, but its role in these cells is unclear...
  8. pmc DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome
    Claudia Canzonetta
    Institute of Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, University of London, 4 Newark Street, London E1 2AT, UK
    Am J Hum Genet 83:388-400. 2008
    ..Using a transchromosomic model of DS, we show that a 30%-60% reduced expression of Nrsf/Rest (a key regulator of pluripotency and neuronal differentiation) is an alteration that persists in trisomy 21 ..
  9. pmc REST regulates distinct transcriptional networks in embryonic and neural stem cells
    Rory Johnson
    Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore
    PLoS Biol 6:e256. 2008
    ..The transcriptional repressor RE1-silencing transcription factor (REST) plays important but distinct regulatory roles in embryonic (ESC) and neural (NSC) stem cells...
  10. pmc A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome
    Alexander G Bassuk
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 83:572-81. 2008
    ..This report identifies a mutation in PRICKLE1 (also known as RILP for REST/NRSF interacting LIM domain protein) in all three of these pedigrees...
  11. pmc Rest-mediated regulation of extracellular matrix is crucial for neural development
    Yuh Man Sun
    Centre for the Cellular Basis of Behaviour, The James Black Centre, Institute of Psychiatry, King s College London, London, UK
    PLoS ONE 3:e3656. 2008
    ..Here, we demonstrate that the expression pattern of the transcription factor Rest mirrors those of pluripotent genes during neural development from embryonic stem (ES) cells and an early abrogation ..
  12. ncbi RE1 Silencing transcription factor maintains a repressive chromatin environment in embryonic hippocampal neural stem cells
    Deborah J Greenway
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, United Kingdom
    Stem Cells 25:354-63. 2007
    ..Recent evidence has implicated the RE1 silencing transcription factor (REST) in neuronal differentiation...
  13. doi DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome
    Aude Marie Lepagnol-Bestel
    INSERM U675, IFR02, Faculte de Medecine Xavier Bichat, Universite Paris Diderot Paris 7, Paris, France
    Hum Mol Genet 18:1405-14. 2009
    ..dosage imbalance deregulates chromosomal clusters of genes located near neuron-restrictive silencer factor (REST/NRSF) binding sites. We found that Dyrk1a binds the SWI/SNF complex known to interact with REST/NRSF...
  14. doi Is REST required for ESC pluripotency?
    Helle F Jørgensen
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK
    Nature 457:E4-5; discussion E7. 2009
    The DNA-binding protein REST (also called NRSF) is a transcriptional repressor that targets many neuronal genes and is abundant in human and mouse pluripotent embryonic stem cells (ESCs). In a recent Letter to Nature, Singh et al...
  15. doi Is REST a regulator of pluripotency?
    Noel J Buckley
    King s College London, Institute of Psychiatry, Centre for the Cellular Basis of Behaviour, James Black Centre, 125 Coldharbour Lane, London SE5 9NU, UK
    Nature 457:E5-6; discussion E7. 2009
    ..Singh et al. claim that the transcriptional repressor REST is such a regulator and that a 50% reduction of REST in ESCs leads to activation of a specific microRNA, miR-21, ..
  16. pmc Dynamic status of REST in the mouse ESC pluripotency network
    Sanjay K Singh
    Department of Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas, United States of America
    PLoS ONE 7:e43659. 2012
    b>REST is abundantly expressed in mouse embryonic stem cells (ESCs). Many genome-wide analyses have found REST to be an integral part of the ESC pluripotency network...
  17. pmc REST regulates the pool size of the different neural lineages by restricting the generation of neurons and oligodendrocytes from neural stem/progenitor cells
    Matthew V Covey
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York, NY 11794, USA
    Development 139:2878-90. 2012
    b>REST is a master repressor of neuronal genes; however, whether it has any role during nervous system development remains largely unknown...
  18. doi NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP
    Mei Yu
    State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China
    Neurobiol Aging 34:916-27. 2013
    ..Abnormal gene expression plays a critical role in its pathogenesis. Neuron-restrictive silencer factor (NRSF)/neuronal repressor element-1 silencing transcription factor (REST), a member of the zinc finger transcription ..
  19. pmc REST-mediated recruitment of polycomb repressor complexes in mammalian cells
    Nikolaj Dietrich
    Biotech Research and Innovation Centre BRIC and Centre for Epigenetics, University of Copenhagen, Copenhagen, Denmark
    PLoS Genet 8:e1002494. 2012
    ..Here we present evidence for an interaction between the transcription factor REST, PRC1, and PRC2 and show that RNF2 and REST co-regulate a number of neuronal genes in human teratocarcinoma cells (..
  20. pmc REST and CoREST modulate neuronal subtype specification, maturation and maintenance
    Joseph J Abrajano
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 4:e7936. 2009
    The repressor element-1 silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a master regulator of neuronal gene expression...
  21. pmc Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development
    Chai An Mao
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
    Dev Biol 349:90-9. 2011
    ..The transcriptional repressor REST prevents progenitors from undergoing differentiation...
  22. doi Can controversies be put to REST?
    Helle F Jørgensen
    Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nature 467:E3-4; discussion E5. 2010
    The contribution of REST to embryonic stem (ES) cell pluripotency has been uncertain. Two years ago, Singh et al...
  23. pmc NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function
    Koichiro Kuwahara
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan
    EMBO J 22:6310-21. 2003
    ..Here we show that neuron-restrictive silencer factor (NRSF), a transcriptional repressor, selectively regulates expression of multiple fetal cardiac genes, including those ..
  24. ncbi The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes
    C J Schoenherr
    Division of Biology 216 76, California Institute of Technology, Pasadena 91125
    Science 267:1360-3. 1995
    The neuron-restrictive silencer factor (NRSF) binds a DNA sequence element, called the neuron-restrictive silencer element (NRSE), that represses neuronal gene transcription in nonneuronal cells...
  25. ncbi NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis
    Z F Chen
    Howard Hughes Medical Institute, California Institute of Technology, Pasadena 91125, USA
    Nat Genet 20:136-42. 1998
    The neuron-restrictive silencer factor NRSF (also known as REST and XBR) can silence transcription from neuronal promoters in non-neuronal cell lines, but its function during normal development is unknown...
  26. ncbi REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons
    J A Chong
    Department of Neurobiology and Behavior, State University of New York at Stony Brook 11794 5230
    Cell 80:949-57. 1995
    ..We have cloned cDNA coding for a transcription factor (REST) that binds to this silencer element...
  27. ncbi Knockout of REST/NRSF shows that the protein is a potent repressor of neuronally expressed genes in non-neural tissues
    F S Jones
    Department of Neurobiology, Scripps Research Institute, La Jolla, California 92037, USA
    Bioessays 21:372-6. 1999
    The protein repressor element 1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF) is a negative regulator of neuronal genes that contain a particular DNA sequence, the neuron restrictive silencer element (NRSE)...
  28. pmc Differential regulation by multiple promoters of the gene encoding the neuron-restrictive silencer factor
    C Koenigsberger
    Department of Neurobiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 97:2291-6. 2000
    NRSF/REST is a protein that silences transcription of a number of genes that contain a DNA element called the neuron-restrictive silencer element (NRSE)...
  29. ncbi The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex
    J A Grimes
    Howard Hughes Medical Institute and Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York, 11794 5230, USA
    J Biol Chem 275:9461-7. 2000
    The repressor REST/NRSF restricts expression of a large set of genes to neurons by suppressing their expression in non-neural tissues. We find that REST repression involves two distinct repressor proteins...
  30. ncbi Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription
    K A Seth
    Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:13917-23. 2001
    ..repression by the repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) in many neuron-specific genes...
  31. ncbi Cell-type non-selective transcription of mouse and human genes encoding neural-restrictive silencer factor
    T Kojima
    Department of Molecular Genetics, National Institute for Longevity Sciences, Gengo 36 3, Morioka, Oobu, 474 8522, Aichi, Japan
    Brain Res Mol Brain Res 90:174-86. 2001
    ..silencer (NRS) has been identified in at least twenty neuron-specific genes, and its nuclear DNA-binding factor, NRSF (also known as RE1-silencing transcription factor (REST)), has been cloned from human and rat, and was shown to ..
  32. ncbi Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
    Chiara Zuccato
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Nat Genet 35:76-83. 2003
    ..cytoplasmic sequestering of repressor element-1 transcription factor/neuron restrictive silencer factor (REST/NRSF), the transcription factor that binds to NRSE...
  33. pmc Distinct profiles of REST interactions with its target genes at different stages of neuronal development
    Yuh Man Sun
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Mol Biol Cell 16:5630-8. 2005
    ..is present at all three stages and a key to neuronal differentiation is the RE1-silencing transcription factor (REST/NRSF)...
  34. ncbi REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis
    Nurit Ballas
    Howard Hughes Medical Institute, Dept of Neurology and Behavior, The State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Cell 121:645-57. 2005
    Regulation of neuronal gene expression is critical to central nervous system development. Here, we show that REST regulates the transitions from pluripotent to neural stem/progenitor cell and from progenitor to mature neuron...
  35. pmc Activation of REST/NRSF target genes in neural stem cells is sufficient to cause neuronal differentiation
    Xiaohua Su
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Mol Cell Biol 24:8018-25. 2004
    REST/NRSF is a transcriptional repressor that acts at the terminal stage of the neuronal differentiation pathway and blocks the transcription of several differentiation genes...
  36. ncbi The repressor element silencing transcription factor (REST)-mediated transcriptional repression requires the inhibition of Sp1
    Valérie Plaisance
    Department of Internal Medicine, University of Lausanne, 1005 Lausanne, Switzerland
    J Biol Chem 280:401-7. 2005
    ..of genes that are targets of an important transcriptional repressor named RE-1 silencing transcription factor (REST)...
  37. pmc Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes
    Alexander W Bruce
    Schools of Biochemistry and Microbiology and Biomedical Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    Proc Natl Acad Sci U S A 101:10458-63. 2004
    ..repressor element 1/neuron-restrictive silencer element (RE1/NRSE)] and potential target genes of RE1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) within the human, mouse, and Fugu rubripes genomes...
  38. ncbi Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Biol Chem 279:46464-73. 2004
    ..One of the neuronal-specific transcription regulators, neuron-restrictive silencer factor (NRSF), has been shown to repress the expression of neuron-specific genes in non-neuronal cells...
  39. ncbi Critical role of the transcriptional repressor neuron-restrictive silencer factor in the specific control of connexin36 in insulin-producing cell lines
    David Martin
    Department of Internal Medicine, University Hospital, CHUV 1011 Lausanne, Switzerland
    J Biol Chem 278:53082-9. 2003
    ..conserved between rodent and human species was recognized and binds the neuron-restrictive silencing factor (NRSF/REST)...
  40. ncbi Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat
    K Palm
    Department of Neuroscience, Developmental Neuroscience, Biomedical Center, Uppsala University, Box 587, S 751 23, Uppsala, Sweden
    Brain Res Mol Brain Res 72:30-9. 1999
    Neuron-restrictive silencer factor (NRSF), also known as repressor element RE1 binding transcription factor (REST) or repressor binding to the X2 box (XBR) (REST/NRSF/XBR), is a zinc finger transcription factor that during early ..
  41. doi Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs
    David C Bersten
    School of Molecular and Biomedical Science Biochemistry and Australian Research, Council Special Research Centre for the Molecular Genetics of Development, The University of Adelaide, Adelaide, South Australia, Australia Electronic address
    Biochim Biophys Acta 1839:13-24. 2014
    ..of NPAS4 mRNA is actively repressed by RE-1 silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) in embryonic stem cells and non-neuronal cells by binding multiple sites within the promoter and Intron I of NPAS4...
  42. pmc Corepressor for element-1-silencing transcription factor preferentially mediates gene networks underlying neural stem cell fate decisions
    Joseph J Abrajano
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:16685-90. 2010
    The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) silences neuronal genes in neural stem cells (NSCs) and nonneuronal cells through its role as a dynamic modular platform for ..
  43. doi REST/NRSF-induced changes of ChAT protein expression in the neocortex and hippocampus of the 3xTg-AD mouse model for Alzheimer's disease
    E Orta-Salazar
    Centro Universitario de Ciencias Biologicas y Agropecuarias, Universidad de Guadalajara, Zapopan, Jal CP 45110, México University of CA, Irvine Campus, USA
    Life Sci 116:83-9. 2014
    ..The objective of this work was to determine the REST/NRSF involvement in altered ChAT expression in the neocortex and hippocampus of an AD transgenic mouse (homozygous ..
  44. doi Cysteine 397 plays important roles in the folding of the neuron-restricted silencer factor/RE1-silencing transcription factor
    Yan Zhang
    State Key Laboratory of Bio organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
    Biochem Biophys Res Commun 414:309-14. 2011
    The neuron-restrictive silencer factor/RE1-silencing transcription factor (NRSF/REST) is regarded as not only a key transcriptional repressor but also an activator in neuron gene expression by specifically interacting with neuron-..
  45. pmc Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia
    Shiran Naftelberg
    Department of Human Molecular Genetics and Biochemestry Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    PLoS Genet 12:e1006486. 2016
    ..Thus, we have identified the molecular pathway that leads to neurodegeneration in FD and have demonstrated that phosphatidylserine treatment has the potential to slow progression of neurodegeneration...
  46. pmc Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity
    Zhilian Jia
    Key Laboratory of Systems Biomedicine Ministry of Education, Center for Comparative Biomedicine, Institute of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio X Center, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China
    Mol Cell Biol 34:3895-910. 2014
    ..the insulator CCCTC-binding factor (CTCF) and the repressor neuron-restrictive silencer factor (NRSF, also known as REST) and is required for the development and connectivity of GP...
  47. pmc A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells
    Masahide Seki
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan
    PLoS ONE 9:e95374. 2014
    We detected and characterized the binding sites of the representative Rest complex components Rest, Sin3A, and Lsd1. We compared their binding patterns in mouse embryonic stem (ES) cells and epiblast stem (EpiS) cells...
  48. pmc MicroRNA-9 controls dendritic development by targeting REST
    Sebastian A Giusti
    Department of Molecular Neurobiology, Max Planck Institute of Psychiatry, Munich, Germany
    elife 3:. 2014
    ..Furthermore, we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth.
  49. pmc miR-218 Involvement in Cardiomyocyte Hypertrophy Is Likely through Targeting REST
    Jing jing Liu
    Key Laboratory of Arrhythmias, Ministry of Education, Tongji University School of Medicine, Shanghai 200092, China
    Int J Mol Sci 17:. 2016
    ..In addition, we identified RE1-silencing transcription factor (REST) as a novel target of miR-218; it negatively regulated the expression of REST in hypertrophic cardiomyocytes and ..
  50. doi White spotting phenotype induced by targeted REST disruption during neural crest specification to a melanocyte cell lineage
    Hitomi Aoki
    Department of Tissue and Organ Development, Regeneration, and Advanced Medical Science, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    Genes Cells 20:439-49. 2015
    ..b>Rest, also known as NRSF (neuro-restrictive silencer factor), is a regulator of neuronal development and function and ..
  51. pmc An RNA binding protein promotes axonal integrity in peripheral neurons by destabilizing REST
    Francesca Cargnin
    Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239
    J Neurosci 34:16650-61. 2014
    The RE1 Silencing Transcription Factor (REST) acts as a governor of the mature neuronal phenotype by repressing a large consortium of neuronal genes in non-neuronal cells...
  52. pmc Specificity protein 1 (Sp1)-dependent activation of the synapsin I gene (SYN1) is modulated by RE1-silencing transcription factor (REST) and 5'-cytosine-phosphoguanine (CpG) methylation
    Francesco Paonessa
    Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
    J Biol Chem 288:3227-39. 2013
    ..SYN1 gene transcription is suppressed in non-neural tissues by the RE1-silencing transcription factor (REST); however, the molecular mechanisms that allow the constitutive expression of this genetic region in neurons have ..
  53. doi Repressor element 1 silencing transcription factor couples loss of pluripotency with neural induction and neural differentiation
    Chiara Soldati
    Centre for the Cellular Basis of Behaviour, Department of Neuroscience, The James Black Centre, King s College London, Institute of Psychiatry, London, UK
    Stem Cells 30:425-34. 2012
    ..One transcription factor, REST (repressor element 1 silencing transcription factor), has been linked with terminal differentiation of neural ..
  54. doi Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis
    Hitomi Aoki
    Department of Tissue and Organ Development, Gifu University Graduate School of Medicine, Gifu, Japan
    Development 139:667-77. 2012
    Rest (RE1-silencing transcription factor, also called Nrsf) is involved in the maintenance of the undifferentiated state of neuronal stem/progenitor cells in vitro by preventing precocious expression of neuronal genes...
  55. pmc Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST)
    Karen M J Van Loo
    Department of Neuropathology, University of Bonn Medical Center, D 53105 Bonn, Germany
    J Biol Chem 287:15489-501. 2012
    ..2 promoter was effectively counteracted by the repressor element 1-silencing transcription factor (REST). Thus, Egr1 and REST can bi-directionally regulate Ca(V)3...
  56. pmc Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    Andre J Faure
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2163-75. 2012
    ..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels...
  57. doi Dysregulation of REST-regulated coding and non-coding RNAs in a cellular model of Huntington's disease
    Chiara Soldati
    Department of Neuroscience, Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King s College London, London, UK
    J Neurochem 124:418-30. 2013
    ..Repressor Element-1 Silencing Transcription Factor (REST) is a repressor whose association with Htt in the cytoplasm is disrupted in HD, leading to increased nuclear REST ..
  58. ncbi A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice
    Shigeki Iwase
    Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba Science City, Ibaraki 305 8572, Japan
    FEBS Lett 580:3129-35. 2006
    ..Although Bhc80-deficient mice showed no developmental defect in the neuronal and non-neuronal tissues, Bhc80 is indispensable for the survival of neonatal pups...
  59. pmc Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene
    Chun Sung Kim
    Department of Pharmacology, University of Minnesota Medical School, 6 120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Nucleic Acids Res 34:6392-403. 2006
    ..to repress the MOR transcription in specific neuronal cells, depending on neuron-restriction silence factor (NRSF) expression levels [C.S.Kim, C.K.Hwang, H.S.Choi, K.Y.Song, P.Y.Law, L.N. Wei and H.H.Loh (2004) J. Biol. Chem...
  60. pmc The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development
    Jaya Visvanathan
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 21:744-9. 2007
    ..Our results suggest that, during CNS development, timely down-regulation of SCP1 is critical for inducing neurogenesis, and miR-124 contributes to this process at least in part by down-regulating SCP1 expression...
  61. ncbi Progression from extrinsic to intrinsic signaling in cell fate specification: a view from the nervous system
    T Edlund
    Department of Microbiology, University of Umea, Sweden
    Cell 96:211-24. 1999
  62. ncbi Neuron-restrictive silencer factor regulates the N-methyl-D-aspartate receptor 2B subunit gene in basal and ethanol-induced gene expression in fetal cortical neurons
    Mei Qiang
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Mol Pharmacol 67:2115-25. 2005
    Neuron-restrictive silencer factor (NRSF) is a transcriptional repressor of multiple neuronal genes...
  63. ncbi Yin yang 1 directly regulates the transcription of RE-1 silencing transcription factor
    Lichun Jiang
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    J Neurosci Res 86:1209-16. 2008
    The RE-1 silencing transcription factor (REST) is a master transcription factor that plays a critical role in embryo development, especially during the process of neurogenesis and neural plasticity...
  64. pmc Transcription profiling of HCN-channel isotypes throughout mouse cardiac development
    Patrick A Schweizer
    Universitatsklinikum Heidelberg, Innere Medizin III, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
    Basic Res Cardiol 104:621-9. 2009
    ..Here, we describe the transcription profiles of the four HCN genes, the NRSF, KCNE2 and Kir2.1 genes from embryonic stage E9.5 dpc to postnatal day 120 in the mouse...
  65. ncbi Molecular mechanisms regulating cell type specific expression of BMP/RA Inducible Neural-specific Protein-1 that suppresses cell cycle progression: roles of NRSF/REST and DNA methylation
    Nakatani Toshiyuki
    Division of Innovative Research, Creative Research Initiative Sousei, Hokkaido University Sapporo 001 0020, Japan
    Brain Res Mol Brain Res 125:47-59. 2004
    ..These results strongly suggest that BRINP1-NRSE determines neural-specific expression of BRINP1, while hypermethylation of the BRINP1-CpG island suppresses BRINP1 expression in NIH 3T3 cells...
  66. pmc RE1 silencing transcription factor is involved in regulating neuron-specific expression of alpha-internexin and neurofilament genes
    Gee Y Ching
    Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurochem 109:1610-23. 2009
    ..We have found that the RE1 silencing transcription factor (REST) plays a contributory role in the neuron-specific expression of the alpha-internexin, NF-H and ..
  67. pmc REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Chandler Medical Center, 800 Rose Street, Lexington, KY 40536 0298, USA
    Mol Cell Biol 23:9025-31. 2003
    ..RE-1 silencing transcription factor/neuron-restrictive silencer factor) and the transcriptional regulator REST4 share an N-terminal zinc finger domain structure involved in nuclear targeting...
  68. pmc Differential deployment of REST and CoREST promotes glial subtype specification and oligodendrocyte lineage maturation
    Joseph J Abrajano
    Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 4:e7665. 2009
    The repressor element-1 (RE1) silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a master transcriptional regulator that binds to numerous genomic RE1 sites where it acts as a molecular scaffold for dynamic ..
  69. ncbi Verification and initial annotation of the NIA mouse 15K cDNA clone set
    G J Kargul
    Nat Genet 28:17-8. 2001
  70. doi Role of AP-1 and RE-1 binding sites in matrix metalloproteinase-2 transcriptional regulation in skeletal muscle atrophy
    Xuhui Liu
    Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Biochem Biophys Res Commun 396:219-23. 2010
    ..Novel information gained from this study has improved our understanding of in vivo transcriptional regulation of MMP-2 in skeletal muscle atrophy...
  71. pmc REST regulates DYRK1A transcription in a negative feedback loop
    Mei Lu
    Otolaryngology Lab, Qilu Hospital of Shandong University, Jinan 250012, China
    J Biol Chem 286:10755-63. 2011
    ..REST (RE1 silencing transcription factor) plays vital roles in neuronal differentiation...
  72. pmc BMP-induced REST regulates the establishment and maintenance of astrocytic identity
    Jun Kohyama
    Laboratory of Molecular Neuroscience, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara 630 0101, Japan
    J Cell Biol 189:159-70. 2010
    ..We show here that the expression of a transcriptional repressor, RE1 silencer of transcription (REST)/neuron-restrictive silencer factor (NRSF), is up-regulated and sustained by BMP signal activation in the course of ..
  73. pmc Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation
    Ali C Ravanpay
    Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell Neurosci 44:178-89. 2010
    ..It is known that NeuroD2 and related bHLH transcription factors induce neuronal differentiation, REST represses neuronal differentiation, and Zfhx1a prevents myogenic gene expression...
  74. ncbi Pathophysiological remodeling of mouse cardiac myocytes expressing dominant negative mutant of neuron restrictive silencing factor
    Makoto Takano
    Department of Physiology, Jichi Medical University, Tochigi, Japan
    Circ J 74:2712-9. 2010
    ....
  75. doi Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease
    Chiara Soldati
    Department of Neuroscience and Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King s College London, The James Black Centre, London, UK
    J Neurochem 116:415-25. 2011
    ..of HD progression and one of the most prominent is repressor element 1 (RE1) silencing transcription factor (REST)...
  76. pmc HuB/C/D, nPTB, REST4, and miR-124 regulators of neuronal cell identity are also utilized in the lens
    Claudine L Bitel
    Department of Pharmacology and Physiology and Rutgers UMDNJ Integrative Neurosciences Program, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Mol Vis 16:2301-16. 2010
    ..factors are replaced by what has been considered neuron-specific HuB/C/D, nPTB, and alternatively spliced REST (REST4), which work with miR-124 to activate this battery of genes, comprehensively reprogram neuronal alternative ..
  77. pmc Transcriptional activation of REST by Sp1 in Huntington's disease models
    Myriam Ravache
    Institute of Genetics and Molecular and Cellular Biology IGBMC, U964 Centre National de Recherche Scientifique CNRS UMR 1704 Université de Strasbourg, Illkirch, France
    PLoS ONE 5:e14311. 2010
    ..b>REST (Repressor Element-1 Silencing Transcription Factor), a key regulator of neuronal differentiation, is also ..
  78. doi RE1-silencing transcription factor (REST) and REST-interacting LIM domain protein (RILP) affect P19CL6 differentiation
    Masahito Shimojo
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, 741 South Limestone St, BBSRB, Lexington, KY 40536 0509, USA
    Genes Cells 16:90-100. 2011
    ..REST/NRSF-interacting LIM domain protein (RILP) is required for the nuclear targeting and function of REST...
  79. pmc Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy
    Wei Wang
    Department of Microbiology and Physiological Systems and Program in Neuroscience, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Biol Cell 22:868-79. 2011
    ..The trans-repressor RE1 silencing transcription factor (REST) occupied the Gabra6 proximal promoter in CGN progenitors and early postmitotic CGNs, and its ..
  80. doi Ethanol-induced neurodegeneration in NRSF/REST neuronal conditional knockout mice
    L Cai
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Neuroscience 181:196-205. 2011
    ..At postnatal day 6, ethanol significantly increased the expression of REST4, a neuron-specific truncated form of NRSF, in the brains of wild type mice, and this effect was diminished in nrsf ..
  81. pmc REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements
    Xiaojun Ren
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109 0650, USA
    Mol Cell Biol 31:2100-10. 2011
    ..We found that REST and nine REST-associated proteins copurified with Cbx family PcG proteins from mouse embryonic stem (ES) cells...
  82. doi Genetic ablation of a candidate tumor suppressor gene, Rest, does not promote mouse colon carcinogenesis
    Yuichiro Hatano
    Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu, Japan
    Cancer Sci 102:1659-64. 2011
    ..Repressor element 1 silencing factor (REST ), which was originally discovered as a transcriptional repressor of neuronal genes, plays an important role in ..
  83. pmc The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells
    Zhengliang Gao
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 31:9772-86. 2011
    ..in vertebrate development is repressor element 1-silencing transcription/neuron-restrictive silencer factor (REST/NRSF)--thought to regulate hundreds of neuron-specific genes--yet its function in the adult brain remains elusive...
  84. pmc Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI)
    Moumita Datta
    Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, 1 AF Bidhan Nagar, Kolkata 700 064, India
    J Biol Chem 286:33759-69. 2011
    ..Here we report that RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a new transcriptional target of HIPPI...
  85. doi Cross-regulation between an alternative splicing activator and a transcription repressor controls neurogenesis
    Bushra Raj
    Banting and Best Department of Medical Research, Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Mol Cell 43:843-50. 2011
    ..nSR100 directly promotes alternative splicing of REST transcripts to produce a REST isoform (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells...
  86. pmc Repressor element 1 silencing transcription factor (REST) controls radial migration and temporal neuronal specification during neocortical development
    Gail Mandel
    Department of Neurobiology and Behavior, and Howard Hughes Medical Institute, State University of New York, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 108:16789-94. 2011
    ..Here, we show that the transcriptional repressor, repressor element 1 silencing transcription factor (REST), regulates radial migration and the timing of neural progenitor differentiation during neocortical development, ..
  87. doi Neuron-restrictive silencer factor causes epigenetic silencing of Kv4.3 gene after peripheral nerve injury
    H Uchida
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Neuroscience 166:1-4. 2010
    ..a conserved neuron-restrictive silencer element (NRSE), a binding site for neuron-restrictive silencer factor (NRSF). Moreover, we found that injury causes an increase in direct NRSF binding to K(v)4...
  88. ncbi Regulation of MMP-2 gene transcription in dermal wounds
    Petra Lynen Jansen
    Interdisciplinary Centre for Clinical Research BIOMAT, University Hospital, RWTH Aachen, Aachen, Germany
    J Invest Dermatol 127:1762-7. 2007
    ..The findings define a crucial role for the enhancer element RE-1 in injury-induced MMP-2 transcription of the skin...
  89. doi NRSF downregulation induces neuronal differentiation in mouse embryonic stem cells
    Shailesh Kumar Gupta
    National Brain Research Centre, Manesar, Gurgaon, Haryana 122050, India
    Differentiation 77:19-28. 2009
    ..in neuronal differentiation is neuron restrictive silencing factor/RE1-silencing transcription factor (NRSF/REST)...

Research Grants1

  1. Study of novel REST/NRSF-Interacting LIM domain Protein
    Masahito Shimojo; Fiscal Year: 2005
    ..the zinc finger transcription factor REST/NRSF, and de-repression by a neuron specific isoform of REST/NRSF called REST4. REST4 is formed through alternative splicing of the REST/NRSF gene in a process regulated by protein kinase All...