Ren2

Summary

Gene Symbol: Ren2
Description: renin 2 tandem duplication of Ren1
Alias: Ren, Ren-2, Ren-B, Rn-2, Rnr, renin-2, angiotensinogenase, submandibular gland renin
Species: mouse

Top Publications

  1. ncbi Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats
    Kenneth D Mitchell
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    J Renin Angiotensin Aldosterone Syst 7:74-86. 2006
  2. ncbi Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1
    S M Vidal
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 14:32-7. 1992
  3. ncbi Vascular effects of COX inhibition and AT1 receptor blockade in transgenic rats harboring mouse renin-2 gene
    Z J Cheng
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Physiol Pharmacol 53:597-613. 2002
  4. ncbi Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1
    W S Moseley
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 5:899-905. 1989
  5. pmc Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling
    Eugene E Lin
    Departments of Biology, University of Virginia, Charlottesville, Virginia and Department of Pediatrics, University of Virginia, Charlottesville, Virginia
    Am J Physiol Regul Integr Comp Physiol 309:R576-84. 2015
  6. pmc Ren-1 and Ren-2 loci are expressed in mouse kidney
    L J Field
    Proc Natl Acad Sci U S A 82:6196-200. 1985
  7. pmc Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats
    Katsunori Isa
    Hypertension and Vascular Research Center, Wake Forest University Health Science, Winston Salem, North Carolina 27157 1032, USA
    Am J Physiol Regul Integr Comp Physiol 297:R111-5. 2009
  8. ncbi Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats
    Z Vanourková
    Department of Experimental Hypertension, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 59:339-45. 2010
  9. ncbi Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse
    J M Szymura
    Biochem Genet 20:1211-9. 1982
  10. ncbi Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
    P Lindahl
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 125:3313-22. 1998

Research Grants

  1. RENIN CELL FATE IN THE KIDNEY VASCULATURE
    Roberto Gomez; Fiscal Year: 2005
  2. Web-Based System for Research Protocol Submission
    Roberto Gomez; Fiscal Year: 2003
  3. STRUCTURAL AND FUNCTIONAL DEVELOPMENT OF THE KIDNEY
    Roberto Gomez; Fiscal Year: 2006

Scientific Experts

  • Michaela Erbanova
  • Taiji Matsusaka
  • M G Sharp
  • Kathryn J Wiggins
  • K D Mitchell
  • Jennifer L Wilkinson-Berka
  • Kristopher R Schwab
  • ROBERTO ARIEL GOMEZ
  • Jorg Peters
  • Andrea Hartner
  • E M Perera
  • Vincent G Demarco
  • Mark C Chappell
  • Carlos M Ferrario
  • Nancy T Pirro
  • L Cervenka
  • Alexandra Sporkova
  • Z Vanourková
  • Ludek Cervenka
  • Herbert J Kramer
  • Jewell A Jessup
  • Patricia E Gallagher
  • Katharina Machura
  • Leanne Groban
  • Karl D Pendergrass
  • Eugene E Lin
  • Michael Bader
  • Libor Kopkan
  • Bruce D Hammock
  • John D Imig
  • Z Husková
  • Zuzana Husková
  • H J Kramer
  • Maria A Garcia-Espinosa
  • Hao Wang
  • Söhnke Hinrichs
  • Björn Neubauer
  • Sarah H Lindsey
  • Zuzana Honetschlägerová
  • Taro Kitazawa
  • Debra I Diz
  • Charlotte Wagner
  • Jonathan A Cohen
  • Adam Whaley-Connell
  • Jason D Fowler
  • Xiaojun Liu
  • Katsunori Isa
  • K Bridget Brosnihan
  • James R Sowers
  • Brian M Westwood
  • Alberto J Schuhmacher
  • A Sauter
  • Yongzhong Wei
  • Liliya M Yamaleyeva
  • Detlev Ganten
  • Eri Nishihara
  • E S Pentz
  • Julie L Lavoie
  • Ivana Vaneckova
  • Ellen S Pentz
  • S Jíchová
  • V Hampl
  • Maria Luisa S Sequeira-Lopez
  • J Sadowski
  • J Herget
  • J Bibova
  • Janusz Sadowski
  • Akira Nishiyama
  • Sárka Jíchová
  • Elzbieta Kompanowska-Jezierska
  • Ovidiu Baltatu
  • Z J Cheng
  • Sung H Hwang
  • Marina S Lin
  • F Sugiyama
  • M L Sequeira Lopez
  • Hossam A Shaltout
  • Clarissa Chagas
  • Takahiro Sato
  • Sibylle Wenzel
  • Yasunobu Uchijima
  • Koichi Nishiyama
  • Christoph Arens
  • Evren Caglayan
  • Klaus Dieter Schluter
  • Yukiko Kurihara
  • Stephan Rosenkranz
  • Yuichiro Arima
  • Zdenka Vanourková
  • Rolf Schreckenberg

Detail Information

Publications85

  1. ncbi Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats
    Kenneth D Mitchell
    Department of Physiology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    J Renin Angiotensin Aldosterone Syst 7:74-86. 2006
    Transgenic rats with inducible angiotensin II (Ang II)-dependent hypertension (strain name: TGR[Cyp1a1-Ren2]) were generated by inserting the mouse Ren2 renin gene, fused to the cytochrome P450 1a1 (Cyp1a1) promoter, into the genome of ..
  2. ncbi Identification and mapping of six microdissected genomic DNA probes to the proximal region of mouse chromosome 1
    S M Vidal
    Department of Biochemistry, McGill University, Montreal, Canada
    Genomics 14:32-7. 1992
    ..These novel polymorphic probes should prove useful for linkage and physical mapping of this chromosomal region...
  3. ncbi Vascular effects of COX inhibition and AT1 receptor blockade in transgenic rats harboring mouse renin-2 gene
    Z J Cheng
    Institute of Biomedicine, Pharmacology, University of Helsinki, Finland
    J Physiol Pharmacol 53:597-613. 2002
    ..The present study also demonstrated that COX does not play a central role in the pathogenesis of Ang II-induced endothelial dysfunction in mREN2 rats...
  4. ncbi Definition of mouse chromosome 1 and 3 gene linkage groups that are conserved on human chromosome 1: evidence that a conserved linkage group spans the centromere of human chromosome 1
    W S Moseley
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 5:899-905. 1989
    ..These studies provide a model for examination of specific evolutionary events...
  5. pmc Aldo-keto reductase 1b7, a novel marker for renin cells, is regulated by cyclic AMP signaling
    Eugene E Lin
    Departments of Biology, University of Virginia, Charlottesville, Virginia and Department of Pediatrics, University of Virginia, Charlottesville, Virginia
    Am J Physiol Regul Integr Comp Physiol 309:R576-84. 2015
    ..In summary, AKR1B7 is expressed within the renin cell throughout development and perturbations to homeostasis, and AKR1B7 is regulated by cAMP levels within the renin cell. ..
  6. pmc Ren-1 and Ren-2 loci are expressed in mouse kidney
    L J Field
    Proc Natl Acad Sci U S A 82:6196-200. 1985
    ..absence or presence of a duplicated copy of the renin structural gene; one-gene strains carry a single renin gene (Ren-1), whereas two-gene strains carry two renin genes (Ren-1 and Ren-2)...
  7. pmc Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats
    Katsunori Isa
    Hypertension and Vascular Research Center, Wake Forest University Health Science, Winston Salem, North Carolina 27157 1032, USA
    Am J Physiol Regul Integr Comp Physiol 297:R111-5. 2009
    ..The antihypertensive effects produced by endogenous neutralization of brain ANG-(1-12) suggest that ANG-(1-12) is functionally active in brain pathways regulating blood pressure...
  8. ncbi Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats
    Z Vanourková
    Department of Experimental Hypertension, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 59:339-45. 2010
    ..3-month-old male Ren-2 transgenic rats (TGR) were treated either with losartan (5 mg kg(-1) day(-1)) or aliskiren (10 mg kg(-1) day(-1)) ..
  9. ncbi Upg-2: a urinary pepsinogen variant located on chromosome 1 of the mouse
    J M Szymura
    Biochem Genet 20:1211-9. 1982
    ..Typing of recombinant inbred strains suggests that the location of the Upg-2 locus is on chromosome 1, in the vicinity of loci coding for other peptidases, namely, Pep-2 and Rnr, and of the Acf-1 locus.
  10. ncbi Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
    P Lindahl
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 125:3313-22. 1998
    ....
  11. ncbi A glutaminase (gis) gene maps to mouse chromosome 1, rat chromosome 9, and human chromosome 2
    B Mock
    Laboratory of Genetics, NCI, Bethesda, Maryland 20892
    Genomics 5:291-7. 1989
    ..Two of these restriction fragments cosegregated and mapped to human chromosome 2 in a region that is syntenic with mouse chromosome 1 and rat chromosome 9...
  12. pmc In vivo expression of angiotensin-(1-7) lowers blood pressure and improves baroreflex function in transgenic (mRen2)27 rats
    Maria A Garcia-Espinosa
    Radiation Oncology Department Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    J Cardiovasc Pharmacol 60:150-7. 2012
    ....
  13. ncbi Combined suppression of the intrarenal and circulating vasoconstrictor renin-ACE-ANG II axis and augmentation of the vasodilator ACE2-ANG 1-7-Mas axis attenuates the systemic hypertension in Ren-2 transgenic rats exposed to chronic hypoxia
    L Cervenka
    Department of Pathophysiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 64:11-24. 2015
    The aim of the present study was to test the hypothesis that chronic hypoxia would aggravate hypertension in Ren-2 transgenic rats (TGR), a well-defined monogenetic model of hypertension with increased activity of endogenous renin-..
  14. pmc Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: studies in Cyp1a1-Ren-2 transgenic rats
    Alexandra Sporkova
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Clin Exp Pharmacol Physiol 41:1003-13. 2014
    ..administration of indole-3-carbinol (I3C), a natural xenobiotic that activates the mouse renin gene in Cyp1a1-Ren-2 transgenic rats. BP was monitored by radiotelemetry...
  15. pmc Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodelling in oophorectomized mRen2.Lewis rats
    Hao Wang
    Department of Anesthesiology, Wake Forest School of Medicine, Winston Salem, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Cardiovasc Res 94:96-104. 2012
    ..Lewis rat, a model emulating the cardiac phenotype of the post-menopausal woman...
  16. ncbi Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system
    L Mazzolai
    Division of Hypertension and Vascular Medicine, University of Lausanne Medical School, Switzerland
    Hypertension 31:1324-30. 1998
    ..These mice develop myocardial hypertrophy without signs of fibrosis independently from the presence of hypertension, demonstrating that local Ang II production is important in mediating the hypertrophic response in vivo...
  17. ncbi Targeted inactivation of the Ren-2 gene in mice
    M G Sharp
    BBSRC Centre for Genome Research, Edinburgh UK University, UK
    Hypertension 28:1126-31. 1996
    ..Wild mouse strains and some inbred laboratory strains have a duplicated renin gene (Ren-2), the physiological significance of which is unclear...
  18. ncbi Dual renin gene targeting by Cre-mediated interchromosomal recombination
    T Matsusaka
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Genomics 64:127-31. 2000
    ..Our study began with the establishment of two lines of mice carrying different mutations in either Ren1 or Ren2. These two genes, both encoding renin, span over 40 kb in tandem on chromosome 1...
  19. ncbi Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d
    E S Pentz
    Department of Pediatrics, University of Virginia, Charlottesville, Virginia 22908, USA
    Physiol Genomics 6:45-55. 2001
    To distinguish the contributions of Ren1(d) and Ren2 to kidney development and blood pressure homeostasis, we placed green fluorescent protein (GFP) under control of the Ren1(d) renin locus by homologous recombination in mice...
  20. ncbi Embryonic origin and lineage of juxtaglomerular cells
    M L Sequeira Lopez
    Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Am J Physiol Renal Physiol 281:F345-56. 2001
    ..We propose that renin cells are less differentiated than (and have the capability to give rise to) smooth muscle cells of the renal arterioles...
  21. ncbi Roles of nitric oxide and oxidative stress in the regulation of blood pressure and renal function in prehypertensive Ren-2 transgenic rats
    Ivana Vaneckova
    Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Kidney Blood Press Res 28:117-26. 2005
    ..O2-) in the regulation of blood pressure (BP) and renal function during the developmental phase of hypertension in Ren-2 transgenic rats (TGR)...
  22. ncbi Evidence supporting a functional role for intracellular renin in the brain
    Julie L Lavoie
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA
    Hypertension 47:461-6. 2006
    ..These data support the concept of an intracellular form of renin in the brain, which may provoke functional changes in fluid homeostasis and BP regulation...
  23. pmc Genetic control of renin activity in the submaxillary gland of the mouse
    C M Wilson
    Proc Natl Acad Sci U S A 74:1185-9. 1977
    ..Studies with the various hybrids indicate that the difference in renin activity between the two strains is apparently due to a single regulatory gene...
  24. ncbi Ovariectomy is protective against renal injury in the high-salt-fed older mRen2. Lewis rat
    Liliya M Yamaleyeva
    Hypertension and Vascular Research Center, Wake Forest University Health Sciences, Winston Salem, NC 27157 1095, USA
    Am J Physiol Heart Circ Physiol 293:H2064-71. 2007
    ..05, n = 6]. We conclude that ovariectomy in the older female mRen2. Lewis rat conveys protection against salt-dependent increase in renal injury...
  25. ncbi Quantitative trait loci associated with blood pressure of metabolic syndrome in the progeny of NZO/HILtJxC3H/HeJ intercrosses
    Eri Nishihara
    Laboratory Animal Resource Center, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, 305 8575, Japan
    Mamm Genome 18:573-83. 2007
    ..These results enhance our understanding of complicated genetic factors of hypertension in metabolic diseases...
  26. ncbi Development of renin expression in the mouse kidney
    A Sauter
    Institut für Physiologie der Universität Regensburg, D 93040 Regensburg, Germany
    Kidney Int 73:43-51. 2008
    ..At all stages of kidney development, renin expression among comparable vessel segments was heterogeneous. Renin expression remained stable after it reached the terminal parts of afferent arterioles...
  27. doi Oxidative stress contributes to pulmonary hypertension in the transgenic (mRen2)27 rat
    Vincent G Demarco
    Department of Child Health, University of Missouri School of Medicine, Columbia, Missouri 65210, USA
    Am J Physiol Heart Circ Physiol 294:H2659-68. 2008
    The transgenic (mRen2)27 (Ren2) rat overexpresses mouse renin in extrarenal tissues, causing increased local synthesis of ANG II, oxidative stress, and hypertension...
  28. pmc A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
    Alberto J Schuhmacher
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Clin Invest 118:2169-79. 2008
    ..In addition, it partially alleviated the observed cardiomyopathies. These mice should help in elucidating the etiology of CS symptoms, identifying additional defects, and evaluating potential therapeutic strategies...
  29. pmc Angiotensin II-induced non-alcoholic fatty liver disease is mediated by oxidative stress in transgenic TG(mRen2)27(Ren2) rats
    Yongzhong Wei
    Department of Internal Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA
    J Hepatol 49:417-28. 2008
    ..The renin-angiotensin system (RAS) plays a vital role in blood pressure regulation and appears to promote hepatic fibrogenesis. We hypothesized that increased RAS activity causes NAFLD due to increased hepatic oxidative stress...
  30. doi Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats
    Kathryn J Wiggins
    Department of Medicine, The University of Melbourne, St Vincent s Hospital, Melbourne, Victoria, Australia
    Nephrology (Carlton) 13:721-9. 2008
    ..In this study the localization of cellular hypoxia in an experimental model of diabetic nephropathy was assessed, and the effect of the angiotensin-converting enzyme inhibitor perindopril on hypoxia evaluated...
  31. pmc CBP and p300 are essential for renin cell identity and morphological integrity of the kidney
    R Ariel Gomez
    Dept of Pediatrics, Univ of Virginia School of Medicine, 409 Lane Rd, MR4 2001, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 296:H1255-62. 2009
    ..Results show that the histone acetyltransferases CBP and p300 are necessary for maintenance of renin cell identity and structural integrity of the kidney...
  32. pmc Regulated renin release from 3T3-L1 adipocytes
    Jason D Fowler
    Department of Integrative Biology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Am J Physiol Endocrinol Metab 296:E1383-91. 2009
    ..In conclusion, the expression and secretion of renin are regulated under a complex series of hormonal and metabolic determinants in mature 3T3-L1 adipocytes...
  33. pmc Dual ACE-inhibition and AT1 receptor antagonism improves ventricular lusitropy without affecting cardiac fibrosis in the congenic mRen2.Lewis rat
    Jewell A Jessup
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Ther Adv Cardiovasc Dis 3:245-57. 2009
    ....
  34. doi Developmental renin expression in mice with a defective renin-angiotensin system
    Katharina Machura
    Institute of Physiology, University of Regensburg, Regensburg, Germany
    Am J Physiol Renal Physiol 297:F1371-80. 2009
    ....
  35. pmc Lack of cardiac fibrosis in a new model of high prorenin hyperaldosteronism
    Jorg Peters
    Institute of Physiology, Univ of Greifswald, Greifswalder Str 11c, D 17495 Karlsburg, Germany
    Am J Physiol Heart Circ Physiol 297:H1845-52. 2009
    ..In I3C-treated cyp1a1 ren-2 transgenic rats, plasma prorenin concentrations were >100-fold elevated (> or = 7.1 + or - 2.6 microg ANG I...
  36. pmc Comparative effect of direct renin inhibition and AT1R blockade on glomerular filtration barrier injury in the transgenic Ren2 rat
    Adam Whaley-Connell
    Department of Internal Medicine, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
    Am J Physiol Renal Physiol 298:F655-61. 2010
    ..an ARB on renal oxidative stress and associated glomerular structural and functional changes in the transgenic Ren2 rat, which manifests hypertension, albuminuria, and increased tissue RAS activity...
  37. pmc Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain
    Jonathan A Cohen
    Hypertension and Vascular Research Center, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1095, USA
    Am J Physiol Renal Physiol 299:F35-42. 2010
    ..We conclude that the increase in uAGT with estrogen depletion or HS likely may be a biomarker for glomerular damage reflecting filtration of the circulating protein in the mRen2...
  38. doi Controlling cardiomyocyte length: the role of renin and PPAR-{gamma}
    Söhnke Hinrichs
    Physiologisches Institut, Justus Liebig Universitat Giessen, Aulweg 149, 35392 Gießen, Germany
    Cardiovasc Res 89:344-52. 2011
    ..Renin and peroxisome proliferator-activated receptor (PPAR-γ) interact directly with cardiomyocytes and influence protein synthesis. We investigated their effects and interaction on the size of cardiomyocytes...
  39. pmc Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren-2 transgenic rats with inducible hypertension
    Zuzana Honetschlägerová
    Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    J Physiol 589:207-19. 2011
    ..and on renal function in transgenic rats with inducible expression of the mouse renin gene (strain name Cyp1a1-Ren-2). Hypertension was induced in these rats by indole-3-carbinol (I3C; 0.3% in the diet) for 12 days...
  40. doi Renin expression in large renal vessels during fetal development depends on functional beta1/beta2-adrenergic receptors
    Björn Neubauer
    Physiologisches Institut, Universitat Regensburg, D 93040 Regensburg, Germany
    Am J Physiol Renal Physiol 301:F71-7. 2011
    ..Furthermore, β-adrenergic receptor input is critical for the expression of renin in large renal vessels during early fetal development...
  41. doi Identification and developmental analysis of endothelin receptor type-A expressing cells in the mouse kidney
    Taro Kitazawa
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Japan
    Gene Expr Patterns 11:371-7. 2011
    ..Ednra-lacZ/EGFP knock-in mice may serve as a useful tool in studies on renal function and pathophysiology of various renal diseases...
  42. ncbi A mouse homeo box-containing gene maps near a developmental mutation
    R E Hill
    Cytogenet Cell Genet 44:171-4. 1987
    ..This gene maps to mouse chromosome 1 near or at the dominant hemimelia locus which is a known mouse developmental mutation...
  43. pmc The mouse Rn locus: S allele of the renin regulator gene results from a single structural gene duplication
    J J Panthier
    EMBO J 1:1417-21. 1982
    ..We have also identified renin genes in mice belonging to different biochemical groups: Mus spretus has one renin gene while M. vrania and M. musculus brevirostris have two renin genes...
  44. pmc Renin angiotensin system in development of mice and men
    A Fogo
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    Am J Pathol 149:1797-801. 1996
  45. pmc Molecular cloning of a mouse submaxillary gland renin cDNA fragment
    F Rougeon
    Proc Natl Acad Sci U S A 78:6367-71. 1981
    ..In vitro translation of mRNAs and RNA blotting experiments have shown that renin mRNA sequences are accumulated in the submaxillary gland of males of AKR and Swiss strains but not in the gland of male BALB/c...
  46. pmc A retroviral provirus closely associated with the Ren-2 gene of DBA/2 mice
    D W Burt
    Nucleic Acids Res 12:8579-93. 1984
    We have determined the entire nucleotide sequence of an intra-cisternal A particle (IAP) genome, associated with the Ren-2 gene of DBA/2 mice. This genome (MIARN) displays features common to other IAP retroviral-like genomes...
  47. pmc Mouse kidney and submaxillary gland renin genes differ in their 5' putative regulatory sequences
    J J Panthier
    Proc Natl Acad Sci U S A 81:5489-93. 1984
    ..The Ren1 and Ren2 genes, encoding the kidney and submaxillary renins, respectively, span about 9.5 kilobases each...
  48. ncbi A molecular genetic approach to gld "autoimmune" disease
    M F Seldin
    Curr Top Microbiol Immunol 137:227-32. 1988
  49. ncbi Establishment of a molecular genetic map of distal mouse chromosome 1: further definition of a conserved linkage group syntenic with human chromosome 1q
    M F Seldin
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 2:48-56. 1988
    ..seven probes on Southern hybridization combined with data from previous studies suggest the gene order Cfh, Pep-3/Ren-1,2, Ly-5, Lamb-2, At-3, Apoa-2/Ly-17,Spna-1...
  50. ncbi Receptors for Fc epsilon and Fc gamma are linked on mouse chromosome 1
    K Huppi
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    J Immunol 141:2807-10. 1988
    ..This finding raises the possibility that a family of Fc receptors could be found in a region that is known to contain immunologically important markers of lymphocyte surface Ag and autoimmune defects...
  51. pmc Genetic analysis of autoimmune gld mice. I. Identification of a restriction fragment length polymorphism closely linked to the gld mutation within a conserved linkage group
    M F Seldin
    Cellular Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892
    J Exp Med 167:688-93. 1988
    ..The gene order was: (centromere) C4bp, Ren-1,2, Ly-5, [At-3/gld], Apoa-2/Ly-17, Spna-1 (telomere)...
  52. ncbi Complete amino acid sequence and maturation of the mouse submaxillary gland renin precursor
    J J Panthier
    Nature 298:90-2. 1982
  53. pmc Close physical linkage of the murine Ren-1 and Ren-2 loci
    K J Abel
    Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, Buffalo, NY 14263
    Nucleic Acids Res 16:2111-26. 1988
    In addition to the Ren-1 gene common to all mice, some inbred strains carry a second copy of the renin structural gene, Ren-2. These two loci are tightly linked genetically on mouse chromosome one...
  54. ncbi Molecular analysis of the murine C4b-binding protein gene. Chromosome assignment and partial gene organization
    S R Barnum
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California 92037
    Biochemistry 28:8312-7. 1989
    ..These sequences may play a role in 3' cleavage of the precursor RNA prior to polyadenylation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  55. ncbi Mapping of the two mouse engrailed-like genes: close linkage of En-1 to dominant hemimelia (Dh) on chromosome 1 and of En-2 to hemimelic extra-toes (Hx) on chromosome 5
    G R Martin
    Department of Anatomy, University of California, San Francisco 94143 0452
    Genomics 6:302-8. 1990
    ..Instead, we suggest that En-1-Dh and En-2-Hx represent paralogous linkage groups that evolved following duplication of a common ancestral chromosome segment...
  56. pmc Expression of murine renin genes in subcutaneous connective tissue
    C D Sigmund
    Department of Molecular, Roswell Park Cancer Institute, Buffalo, NY 14263
    Proc Natl Acad Sci U S A 87:7993-7. 1990
    ..blot analysis of tumor RNA indicated that most of the tumors expressed both T antigen and the endogenous renin gene Ren-1c...
  57. ncbi Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2q
    E Schurr
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Genomics 8:477-86. 1990
    ..The loci investigated were NEB/Neb, ELN/Eln, COL3A1/Col3a1, CRYG/Len-2, FN1/Fn-1, VIL/Vil, and COL6A3/Col6a3. Ren-1,2 and Acrg were included as two proximal mouse chromosome 1 anchor loci...
  58. ncbi Chromosomal location of murine and human IL-1 receptor genes
    N G Copeland
    Mammalian Genetics Laboratory, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21701
    Genomics 9:44-50. 1991
    ..The murine Il-1r1 gene has thus been separated from the IL-1 genes, which lie on murine chromosome 2...
  59. ncbi Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes
    J M Kim
    Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304
    J Immunol 148:3618-23. 1992
    ..The mIL-10 gene was mapped to mouse chromosome 1 and the human IL-10 gene was also mapped to human chromosome 1...
  60. pmc Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse
    C M Wilson
    Proc Natl Acad Sci U S A 75:5623-6. 1978
    ..Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a ..
  61. pmc Kidney and submaxillary gland renins are encoded by two non-allelic genes in Swiss mice
    J J Panthier
    EMBO J 2:675-8. 1983
    ..Comparison of these sequences with the sequence of Swiss mouse SMG renin mRNA we have previously reported, demonstrates that Swiss mice express the two non-allelic genes, Rn1 and Rn2...
  62. ncbi Genetic and endocrine control of renin activity in the submaxillary gland of the mouse
    C M Wilson
    Biochem Genet 19:509-23. 1981
    ....
  63. ncbi Genetic regulation of thermostability of mouse submaxillary gland renin
    C M Wilson
    J Biol Chem 257:217-23. 1982
    ..Basal and induced renin levels are regulated by Rnr, a gene located on Chromosome 1...
  64. ncbi Expression of the mouse ren-2 gene in the small intestine is regulated by food intake
    Y Zhao
    German Institute for High Blood Pressure Research, University of Heidelberg
    Pflugers Arch 424:199-202. 1993
    ..We demonstrate the presence of ren-2 transcripts in the small intestine of DBA/2 mice...
  65. pmc Amino acid sequence of mouse submaxillary gland renin
    K S Misono
    Proc Natl Acad Sci U S A 79:4858-62. 1982
    ..Residues identical in renin and pepsin are distributed throughout the length of the molecules, suggesting a similarity in their overall structures...
  66. ncbi A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland
    N Piccini
    Cell 30:205-13. 1982
    The renin regulatory locus (Rnr) is a genetic element governing mouse submaxillary gland (SMG) renin levels...
  67. ncbi Characterization of a region-specific library of microclones in the vicinity of the Bcg and splotch loci on mouse chromosome 1
    D J Epstein
    Department of Biology, McGill University, Montreal, Quebec
    Genomics 19:163-6. 1994
    ..mapping of 27 microclones from this library, we divided a 56-cM segment of chromosome 1 between the Col3a1 and Ren 1,2 genes into eight intervals defined by anchor loci...
  68. pmc Expression of tissue-specific Ren-1 and Ren-2 genes of mice: comparative analysis of 5'-proximal flanking regions
    L J Field
    Mol Cell Biol 4:2321-31. 1984
    All inbred strains of mice carry the Ren-1 structural gene, which encodes the renin-1 isozyme, the classical renin activity found in kidneys...
  69. pmc Evolution and variation of renin genes in mice
    D P Dickinson
    Genetics 108:651-67. 1984
    Inbred strains of mice carry Ren-1, a gene encoding the thermostable Renin-1 isozyme. Ren-1 is expressed at relatively low levels in mouse submandibular gland and kidney...
  70. pmc Molecular cloning of two distinct renin genes from the DBA/2 mouse
    J J Mullins
    EMBO J 1:1461-6. 1982
    ..Restriction maps of the regions containing the two renin genes are presented, together with nucleotide sequence data locating a complete exon coding for amino acids 268-315 of mouse SMG renin...
  71. ncbi Tissue and gene specificity of mouse renin expression
    L J Field
    Hypertension 6:597-603. 1984
    The Ren-1 locus of mice encodes the protease renin, which with converting enzyme processes angiotensinogen to the potent vasopressor angiotensin II...
  72. pmc Angiotensin-converting enzyme is a modifier of hypertensive end organ damage
    Xiaojun Liu
    Molecular Physiology Laboratory, Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    J Biol Chem 284:15564-72. 2009
    ....
  73. ncbi Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive rats
    Andrea Hartner
    University Hospital for Children and Adolescents, University of Erlangen Nuremberg, Erlangen, Germany
    Nephrol Dial Transplant 21:1778-85. 2006
    b>Ren-2 transgenic hypertensive rats develop malignant hypertensive nephrosclerosis despite low to normal plasma angiotensin II and suppressed renal renin...
  74. ncbi Valsartan but not atenolol improves vascular pathology in diabetic Ren-2 rat retina
    Jennifer Louise Wilkinson-Berka
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Am J Hypertens 20:423-30. 2007
    To determine whether angiotensin type 1 receptor blockade (AT1-RB) or antihypertensive therapy per se, attenuates acellular capillaries and proliferating endothelial cells in the retina of diabetic Ren-2 rats.
  75. ncbi X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins
    V Dhanaraj
    Department of Crystallography, Birkbeck College, London, UK
    Nature 357:466-72. 1992
    ....
  76. pmc Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats
    Karl D Pendergrass
    Hypertension and Vascular Disease Ctr, Wake Forest Univ Health Sciences, Winston Salem, NC 27157 1095, USA
    Am J Physiol Heart Circ Physiol 295:H10-20. 2008
    ..The enhanced activity of the RAAS in male congenics may contribute to the higher pressure and tissue injury evident in the strain...
  77. ncbi The nucleotide sequence of a mouse renin-encoding gene, Ren-1d, and its upstream region
    D W Burt
    Department of Biochemistry, University of Leicester, U K
    Gene 84:91-104. 1989
    The renin-encoding genes have been cloned from high (Ren-1d, Ren-2d)- and low (Ren-1c)-renin-producing strains of mice (DBA/2J and C57BL/10). Each of the genes is approx. 9.6 kb in length and consists of nine exons and eight introns...
  78. ncbi Concordance of murine quantitative trait loci for salt-induced hypertension with rat and human loci
    F Sugiyama
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 71:70-7. 2001
    ....
  79. ncbi Tescalcin, a novel gene encoding a putative EF-hand Ca(2+)-binding protein, Col9a3, and renin are expressed in the mouse testis during the early stages of gonadal differentiation
    E M Perera
    Division of Pediatric Endocrinology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33136, USA
    Endocrinology 142:455-63. 2001
    ..5 dpc. RENIN: mRNA was localized in cells of the interstitium and cells at the border between the gonad and mesonephros. Expression of RENIN: in the ovary was not detected using standard conditions...
  80. ncbi Renal function in hypertensive rats transgenic for mouse renin gene
    J E Springate
    Department of Pediatrics, State University of New York at Buffalo School of Medicine and Biomedical Sciences
    Am J Physiol 266:F731-7. 1994
    The recent development of a transgenic rat strain carrying the mouse ren-2 renin gene [TGR(mRen2)27] has provided a new model of hypertension characterized by suppressed plasma renin levels and marked hyperproreninemia...
  81. ncbi Mapping the gene for LTW-4, a 26,000 molecular weight major protein of mouse liver and kidney
    R W Elliott
    Mol Gen Genet 180:17-22. 1980
    ..The gene order is Dip-1 Rnr - (Sas-1, ald) - Ltw-4 - Mls. The map distance between (Dip-1, Rnr) and Ltw-4 is estimated to be 12.2 +/- 4...
  82. ncbi Abolition of hypertension-induced end-organ damage by androgen receptor blockade in transgenic rats harboring the mouse ren-2 gene
    Ovidiu Baltatu
    Max Delbrück Center for Molecular Medicine MDC, Berlin Buch, Germany
    J Am Soc Nephrol 13:2681-7. 2002
    ..androgen receptors in the development of hypertension and end-organ damage in transgenic rats harboring the mouse Ren-2 renin gene [TGR(mREN2)27] was studied...
  83. ncbi Mapping of the bcl-2 oncogene on mouse chromosome 1
    B A Mock
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    Cytogenet Cell Genet 47:11-5. 1988
    ..The co-segregation of bcl-2 alleles with allelic forms of two other chromosome 1 loci, Ren-1,2 and Spna-1, in a set of back-cross progeny, positions bcl-2 7.8 cM centromeric from Ren-1,2.
  84. ncbi Linkage of genes for laminin B1 and B2 subunits on chromosome 1 in mouse
    R W Elliott
    In Vitro Cell Dev Biol 21:477-84. 1985
    ..4 +/- 3.2 cM distal to the Pep-3 locus. There is no evidence in the mouse for pseudogenes for these proteins...
  85. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...

Research Grants3

  1. RENIN CELL FATE IN THE KIDNEY VASCULATURE
    Roberto Gomez; Fiscal Year: 2005
    ..Finally, some strains of mice have more than one renin gene: Ren 1 and Ren 2. The role of each of these genes in lineage determination and morphogenesis is unknown...
  2. Web-Based System for Research Protocol Submission
    Roberto Gomez; Fiscal Year: 2003
    ..We will try to reach small institutions by annoucements and demonstrations at local, regional and national meetings of the Society for Research Administration, International. ..
  3. STRUCTURAL AND FUNCTIONAL DEVELOPMENT OF THE KIDNEY
    Roberto Gomez; Fiscal Year: 2006
    ..It is anticipated that the Center of Excellence will build on the achievements of the past five years and will lead to improved management of infants and children with renal and urological diseases...