Reln

Summary

Gene Symbol: Reln
Description: reelin
Alias: reeler, reelin, extracellular matrix serine protease
Species: mouse

Top Publications

  1. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
  2. pmc Interaction of reelin with amyloid precursor protein promotes neurite outgrowth
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057 1464, USA
    J Neurosci 29:7459-73. 2009
  3. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
  4. ncbi Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    T Hiesberger
    Department of Molecular Genetics, UT Southwestern Dallas, Texas 75235, USA
    Neuron 24:481-9. 1999
  5. doi Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration
    Aycan Sentürk
    Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max von Laue Str 9, D 60438, Frankfurt am Main, Germany
    Nature 472:356-60. 2011
  6. ncbi Reelin is a ligand for lipoprotein receptors
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Neuron 24:471-9. 1999
  7. ncbi Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice
    M Sheldon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 389:730-3. 1997
  8. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
  9. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
  10. ncbi Reelin is a detachment signal in tangential chain-migration during postnatal neurogenesis
    Iris Hack
    NMDA IBDM, CNRS INSERM Université Méditerranée, Campus de Luminy, 13288 Marseille Cedex 9, France
    Nat Neurosci 5:939-45. 2002

Detail Information

Publications182 found, 100 shown here

  1. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
    The autosomal recessive mouse mutation reeler leads to impaired motor coordination, tremors and ataxia...
  2. pmc Interaction of reelin with amyloid precursor protein promotes neurite outgrowth
    HYANG SOOK HOE
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057 1464, USA
    J Neurosci 29:7459-73. 2009
    ..previous work has shown that APP processing and Abeta production are regulated by the extracellular matrix protein Reelin. In the present study, we examined whether Reelin interacts with APP, and the functional consequences of that ..
  3. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
    ..The mdab1 mutant phenotype is very similar to that of the reeler mouse. The product of the reeler gene, Reelin, is a secreted protein that has been proposed to act as an extracellular signpost for migrating neurons...
  4. ncbi Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation
    T Hiesberger
    Department of Molecular Genetics, UT Southwestern Dallas, Texas 75235, USA
    Neuron 24:481-9. 1999
    The large extracellular matrix protein Reelin is produced by Cajal-Retzius neurons in specific regions of the developing brain, where it controls neuronal migration and positioning...
  5. doi Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration
    Aycan Sentürk
    Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max von Laue Str 9, D 60438, Frankfurt am Main, Germany
    Nature 472:356-60. 2011
    ..The secreted glycoprotein Reelin (also known as RELN) guides migration of neurons by binding to two lipoprotein receptors, the very-low-density ..
  6. ncbi Reelin is a ligand for lipoprotein receptors
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Neuron 24:471-9. 1999
    A signaling pathway involving the extracellular protein Reelin and the intracellular adaptor protein Disabled-1 (Dab1) controls cell positioning during mammalian brain development...
  7. ncbi Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice
    M Sheldon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 389:730-3. 1997
    ..These processes are severely disrupted by mutations in reelin which cause widespread misplacement of neurons and associated ataxia in reeler mice...
  8. ncbi Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex
    Chris Englund
    Department of Pathology, University of Washington, Seattle, Washington 98195 7470, USA
    J Neurosci 25:247-51. 2005
    ....
  9. pmc SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice
    Xiaochang Zhang
    Institute of Developmental Biology and Molecular Medicine, School of Life Science, Fudan University, Shanghai, China
    Neuron 64:173-87. 2009
    ..Syne-2 mutants also display severe defects in learning and memory. These results fill an important gap in our understanding of the mechanism of nuclear movement during brain development...
  10. ncbi Reelin is a detachment signal in tangential chain-migration during postnatal neurogenesis
    Iris Hack
    NMDA IBDM, CNRS INSERM Université Méditerranée, Campus de Luminy, 13288 Marseille Cedex 9, France
    Nat Neurosci 5:939-45. 2002
    During development, Reelin acts on migrating neuronal precursors and controls correct cell positioning in the cortex and other brain structures by a hitherto unidentified mechanism...
  11. ncbi Patterning of the dorsal telencephalon and cerebral cortex by a roof plate-Lhx2 pathway
    E S Monuki
    Division of Neurogenetics, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    Neuron 32:591-604. 2001
    ..These findings provide evidence for the roof plate as an organizing center of the developing cortex and for a roof plate-Lhx2 pathway in cortical patterning...
  12. ncbi The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development
    Yves Jossin
    Developmental Genetics Unit, University of Louvain Medical School, B1200 Brussels, Belgium
    J Neurosci 24:514-21. 2004
    ..receptor (CNR1) as reported previously; (3) Reelin and its central fragment are equally able to rescue the reeler phenotype in a slice culture assay; and (4) anti-receptor antibodies can induce Dab1 phosphorylation but do not ..
  13. ncbi Age-related accumulation of Reelin in amyloid-like deposits
    Irene Knuesel
    Institute of Pharmacology and Toxicology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Neurobiol Aging 30:697-716. 2009
    Accumulating evidence suggest that alterations in Reelin-mediated signaling may contribute to neuronal dysfunction associated with Alzheimer's disease (AD), the most common form of senile dementia...
  14. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008
    ..In Sall1-mutant animals, these patterns of neurogenesis were disrupted. These findings suggest a role for Sall1 in regulating neuronal differentiation and maturation in developing neural structures...
  15. pmc Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation
    Jost Leemhuis
    Center for Neuroscience, Albert Ludwigs University, 79104 Freiburg, Germany
    J Neurosci 30:14759-72. 2010
    ..Depending on the contextual situation, the lipoprotein receptor ligand Reelin can have opposing effects on cortical neurons...
  16. ncbi Reelin regulates neuronal progenitor migration in intact and epileptic hippocampus
    Chao Gong
    Department of Neurology and Program for Neuroscience, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:1803-11. 2007
    ..b>Reelin is a secreted migration guidance cue that persists in the adult rodent and human hippocampus...
  17. ncbi Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons
    Iris Hack
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    Development 134:3883-91. 2007
    ..b>Reeler mice lacking the reelin protein show altered radial neuronal migration resulting in an inversion of cortical ..
  18. pmc DeltaNp73 regulates neuronal survival in vivo
    Fadel Tissir
    Universite Catholique de Louvain, Institute of Neuroscience, Developmental Neurobiology Unit, Brussels, Belgium
    Proc Natl Acad Sci U S A 106:16871-6. 2009
    ..However, ablation of cells that express DeltaNp73 and Wnt3a did neither remove all CRc, nor did they abolish Reelin secretion or generate a reeler-like cortical phenotype...
  19. pmc Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment
    Tohru Matsuki
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Cell 143:826-36. 2010
    The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain lamination and normal dendritogenesis, but the specific mechanisms underlying these actions remain unclear...
  20. ncbi Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip
    Andrew J Fink
    Department of Pathology Neuropathology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:3066-76. 2006
    ..A subset of rhombic lip-derived cells also express reelin, a key regulator of Purkinje cell migrations...
  21. ncbi The reeler mouse as a model of brain development
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur Medical School, Belgium
    Adv Anat Embryol Cell Biol 150:1-106. 1998
  22. ncbi Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Biol 14:606-10. 2004
    ..These migrations are coordinated to ensure normal development. The secreted protein Reelin controls the locations of many types of neurons, and its absence causes the classic "Reeler" phenotype...
  23. ncbi The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells
    Qin Shen
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York 12208, USA
    Nat Neurosci 9:743-51. 2006
    ..Our data demonstrate that neural stem cells change neuropotency during development and have a window of plasticity when restrictions can be reversed...
  24. pmc Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum
    Takaki Miyata
    Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan
    Neural Dev 5:23. 2010
    ..5 (E14.5) in mice. Although the dependence of PP formation on the secreted protein Reelin is well known and a prevailing model suggests that Purkinje cells migrate along the 'radial glial' fibers ..
  25. doi Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala
    Maureen P Boyle
    Allen Institute for Brain Science, Seattle, Washington 98103, USA
    J Comp Neurol 519:2061-89. 2011
    The disrupted cortical lamination phenotype in reeler mice and subsequent identification of the Reelin signaling pathway have strongly informed models of cortical development...
  26. pmc Functional importance of covalent homodimer of reelin protein linked via its central region
    Norihisa Yasui
    Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University, 3 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 286:35247-56. 2011
    b>Reelin is a 3461-residue secreted glycoprotein that plays a critical role in brain development through its action on target neurons...
  27. pmc Dab1 (Disable homolog-1) reelin adaptor protein is overexpressed in the olfactory bulb at early postnatal stages
    Eduardo Martín-López
    Department of Molecular, Cellular, and Developmental Neurobiology, Instituto Cajal CSIC, Madrid, Spain
    PLoS ONE 6:e26673. 2011
    ..bulb undergoes a prominent layering reorganization, but shows not apparent differences between wild type and reeler in the layer organization...
  28. ncbi Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1
    Hans H Bock
    Department of Medicine II, Albert Ludwigs Universitat, Albertstrasse 23, 79104 Freiburg, Germany
    J Biol Chem 279:33471-9. 2004
    ..Dab1) is necessary for the regulation of neuronal positioning in the developing brain by the secreted molecule Reelin. Binding of Reelin to the neuronal apolipoprotein E receptors apoER2 and very low density lipoprotein receptor ..
  29. ncbi Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons
    Mireille Rossel
    EPHE Quantitative Cell Biology, INSERM EMI 343, IFR 122, University Montpellier 2, 34090 Montpellier, France
    Development 132:1175-85. 2005
    ..We identified two cell populations not previously known to be affected in reeler mutants that show a common migratory defect: the olivocochlear efferent neurons and the facial visceral motor ..
  30. ncbi Absence of Fyn and Src causes a reeler-like phenotype
    Gloria Kuo
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 25:8578-86. 2005
    ..Biochemical and in vitro experiments implicate Src and Fyn in the Reelin-dependent tyrosine phosphorylation of Dab1, which controls the positioning of radially migrating neurons in many ..
  31. pmc Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasis
    Cecilia Gonzalez Campo
    INSERM U862, Neurocentre Magendie, Pathophysiology of Synaptic Plasticity, Bordeaux, France
    PLoS ONE 4:e5505. 2009
    b>Reelin is a large secreted protein of the extracellular matrix that has been proposed to participate to the etiology of schizophrenia...
  32. pmc ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin
    Nuno Andrade
    Max F Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, A 1030 Vienna, Austria
    Proc Natl Acad Sci U S A 104:8508-13. 2007
    ..b>Reelin is suggested to induce detachment of neuroblasts from the chains when they arrive at the olfactory bulb...
  33. ncbi Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex
    Marta Nieto
    Department of Neurology, Harvard Medical School and Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 479:168-80. 2004
    ..The patterns of expression of Cux genes suggest potential roles as determinants of the neuronal fate of the upper cortical layer neurons...
  34. ncbi Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss...
  35. ncbi Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration
    Naoya Yamashita
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 26:13357-62. 2006
    ..Here, we show evidence that CRMP1 is involved in Reelin (Reln) signaling to regulate neuronal migration in the cerebral cortex...
  36. pmc Reelin promotes neuronal orientation and dendritogenesis during preplate splitting
    Anna J Nichols
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Cereb Cortex 20:2213-23. 2010
    ..The absence of detectable L6 ectopia in "reeler" cortices at this developmental time point indicates that Reelin-signaling might not regulate L6 neuron migration ..
  37. pmc Cullin 5 regulates cortical layering by modulating the speed and duration of Dab1-dependent neuronal migration
    Sergi Simo
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Neurosci 30:5668-76. 2010
    ..Correct layering requires an extracellular protein, Reelin (Reln), an intracellular signaling molecule, Disabled-1 (Dab1), and an E3 ubiquitin ligase, Cullin-5 (Cul5)...
  38. pmc Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo
    Shenghui He
    Howard Hughes Medical Institute, Department of Internal Medicine, Center for Stem Cell Biology, University of Michigan, 5435 Life Sciences Institute, 210 Washtenaw Ave, Ann Arbor, MI 48109 2216, USA
    Dev Biol 328:257-72. 2009
    ..Bmi-1 over-expression therefore has more pronounced effects in culture and does not appear to be sufficient to induce tumorigenesis in vivo...
  39. pmc Nova2 regulates neuronal migration through an RNA switch in disabled-1 signaling
    Masato Yano
    Laboratory of Molecular Neuro Oncology and Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuron 66:848-58. 2010
    ..b>Reelin signaling, which is mediated in part by a key adaptor, disabled-1 (Dab1), plays a critical but incompletely ..
  40. ncbi Cell migration from the ganglionic eminences is required for the development of hippocampal GABAergic interneurons
    S J Pleasure
    Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143, USA
    Neuron 28:727-40. 2000
    ..Loss of hippocampal interneurons does not appear to have major effects on the early development of hippocampal projection neurons nor on the pathfinding of afferrent tracts...
  41. ncbi Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development
    Lionel Arnaud
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
    Curr Biol 13:9-17. 2003
    ..Dab1 function depends on its tyrosine phosphorylation, which is stimulated by Reelin, an extracellular signaling molecule...
  42. pmc Reconstitution of the Reelin signaling pathway in fibroblasts demonstrates that Dab1 phosphorylation is independent of receptor localization in lipid rafts
    Harald Mayer
    Max F Perutz Laboratories, Department of Medical Biochemistry, University Department at the Vienna Biocenter, Medical University of Vienna, Vienna, Austria
    Mol Cell Biol 26:19-27. 2006
    The Reelin signaling pathway operates in migrating neurons and is indispensable for their correct positioning during embryonic brain development...
  43. pmc Identification of a transient subpial neurogenic zone in the developing dentate gyrus and its regulation by Cxcl12 and reelin signaling
    Guangnan Li
    Department of Neurology, UCSF School of Medicine, San Francisco, CA 94158, USA
    Development 136:327-35. 2009
    ..Timely clearance of neural precursors from their transient location depends on reelin, whereas initial formation of this transient stem cell niche requires Cxcl12-Cxcr4 signaling...
  44. pmc The role of Robo3 in the development of cortical interneurons
    Melissa Barber
    Department of Cell and Developmental Biology, University College London, London, UK
    Cereb Cortex 19:i22-31. 2009
    ..These observations and the results of other recent studies suggest a complex interplay between the 3 Robo receptors in regulating the number, migration and morphological differentiation of cortical interneurons...
  45. pmc Role of Fgf8 signalling in the specification of rostral Cajal-Retzius cells
    Celine Zimmer
    National Institute for Medical Research NIMR, Medical Research Council MRC, Department of Molecular Neurobiology, London NW7 1AA, UK
    Development 137:293-302. 2010
    ..Together, our results shed light on the mechanisms specifying rostral CR cells and further emphasise the crucial role of telencephalic signalling centres in the generation of distinct CR cell populations...
  46. pmc Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons
    Alessandro Sessa
    Division of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy
    Genes Dev 24:1816-26. 2010
    ..We thus propose that INPs are able to control simultaneously the increase of glutamatergic and GABAergic neuronal pools, thereby creating a simple way to intrinsically balance their relative accumulation...
  47. doi Ectopic Reelin induces neuronal aggregation with a normal birthdate-dependent "inside-out" alignment in the developing neocortex
    Ken ichiro Kubo
    Department of Anatomy, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Neurosci 30:10953-66. 2010
    ..b>Reelin, a glycoprotein secreted by Cajal-Retzius neurons in the marginal zone (MZ), is crucial for this "inside-out" ..
  48. doi Go or stop? Divergent roles of Reelin in radial neuronal migration
    Shanting Zhao
    Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, Germany
    Neuroscientist 16:421-34. 2010
    ..b>Reelin, an extracellular matrix protein, is required for neuronal migration...
  49. doi Reelin sets the pace of neocortical neurogenesis
    Jarmila Lakomá
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, Campus de San Juan s n, E 03550 San Juan de Alicante, Spain
    Development 138:5223-34. 2011
    Migration of neurons during cortical development is often assumed to rely on purely post-proliferative reelin signaling...
  50. ncbi Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly
    D Hartmann
    Anatomisches Institut der CAU Kiel, Otto Hahn Platz 8, D 24 118, Kiel, Germany
    Curr Biol 9:719-27. 1999
    ..Physiologically, the presenilins are involved in the Notch and Wnt-beta-catenin signaling pathways...
  51. ncbi Reelin binds alpha3beta1 integrin and inhibits neuronal migration
    L Dulabon
    Department of Biology and Neuroscience, Pennsylvania State University, University Park 16802, USA
    Neuron 27:33-44. 2000
    Mice that are mutant for Reelin or Dab1, or doubly mutant for the VLDL receptor (VLDLR) and ApoE receptor 2 (ApoER2), show disorders of cerebral cortical lamination...
  52. ncbi Reelin in plaques of beta-amyloid precursor protein and presenilin-1 double-transgenic mice
    O Wirths
    Department of Psychiatry, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Neurosci Lett 316:145-8. 2001
    There is circumstantial evidence that the reelin signaling pathway may contribute to neurodegeneration in the adult brain and could be linked to Alzheimer's disease (AD)...
  53. ncbi The role of the first postmitotic cortical cells in the development of thalamocortical innervation in the reeler mouse
    Z Molnar
    University Laboratory of Physiology, Oxford OX1 3PT, United Kingdom
    J Neurosci 18:5746-65. 1998
    In the mutant mouse reeler, the tangential distribution of thalamocortical fibers is essentially normal, even though neurons of the cortical plate accumulate below the entire early-born preplate population (Caviness et al., 1998)...
  54. ncbi Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta
    Uwe Beffert
    Department of Molecular Genetics, Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Biol Chem 277:49958-64. 2002
    b>Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2, thereby inducing tyrosine phosphorylation of the adaptor protein Disabled-1 ..
  55. ncbi Multiple dose-dependent effects of Lis1 on cerebral cortical development
    Michael J Gambello
    Department of Pediatrics and Medicine, University of California, San Diego, La Jolla, California 92093 0627, USA
    J Neurosci 23:1719-29. 2003
    ..These studies reveal the importance of LIS1 levels in orderly cerebral cortical morphogenesis and suggest new insights into the pathogenesis of type I lissencephaly...
  56. ncbi Detection of the reelin breakpoint in reeler mice
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38103, USA
    Brain Res Mol Brain Res 39:234-6. 1996
    Disruption of the reelin gene by partial deletion causes the neurological phenotype known as reeler. Here we report the cloning and sequencing of the reelin breakpoint region from the Jackson reeler strain (rl)...
  57. ncbi Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice
    T Miyata
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    J Comp Neurol 372:215-28. 1996
    We have immunohistochemically investigated the expression of a reeler gene-related antigen in the mouse cerebellum by using a monoclonal antibody, CR-50...
  58. ncbi Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse
    S Alcantara
    Department of Animal and Plant Cell Biology, Faculty of Biology, University of Barcelona, Barcelona 08028, Spain
    J Neurosci 18:7779-99. 1998
    The reelin gene encodes an extracellular protein that is crucial for neuronal migration in laminated brain regions...
  59. ncbi Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice
    Susan Magdaleno
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Neuron 33:573-86. 2002
    The gene mutated in reeler (reelin) encodes a protein secreted by neurons in the developing brain that controls laminar positioning of migrating cells in the CNS by an unknown mechanism...
  60. ncbi Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade
    Nobutaka Ohkubo
    Department of Physiology, School of Medicine, Ehime University, Onsen gun, Ehime 791 0295, Japan
    FASEB J 17:295-7. 2003
    ..Mice lacking Reelin (Reln), double-knockouts lacking the VLDL receptor (VLDLR) and ApoE receptor2 (ApoER2), and mice lacking disabled-..
  61. ncbi Emx1 and Emx2 cooperate to regulate cortical size, lamination, neuronal differentiation, development of cortical efferents, and thalamocortical pathfinding
    Kathie M Bishop
    Molecular Neurobiology Lab, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 457:345-60. 2003
    ..than normal, consistent with deficient cytoarchitecture, probably due in part to reduced numbers of preplate and Reelin-positive Cajal-Retzius neurons. Subplate neurons also exhibit abnormal differentiation in double mutants...
  62. ncbi Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice
    Karl Heinz Weiss
    Anatomisches Institut, Universitat Freiburg, D 79104 Freiburg, Germany
    J Comp Neurol 460:56-65. 2003
    ..of the radial glial scaffold in the dentate gyrus of reeler mice, lacking the extracellular matrix protein Reelin, in scrambler mice, deficient in the intracellular adaptor protein disabled1 (Dab1), which is required for the ..
  63. ncbi Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    In Kyung Park
    Division of Hematology Oncology, Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 423:302-5. 2003
    ..Expression of p16Ink4a and p19Arf in normal HSCs resulted in proliferative arrest and p53-dependent cell death, respectively. Our results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs...
  64. ncbi Dlx2 progenitor migration in wild type and Nkx2.1 mutant telencephalon
    Susana Nery
    Developmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Cereb Cortex 13:895-903. 2003
    ..This recovery may be, at least in part, a result of the late migration of Dlx2 progenitors from the caudal ganglionic eminences (CGE), which, based on our previous work, does not appear to require Nkx2.1 gene function...
  65. ncbi Interaction of reelin signaling and Lis1 in brain development
    Amir H Assadi
    Cain Foundation Laboratories and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 35:270-6. 2003
    ..In the mouse, homozygous mutations in Reln result in the reeler phenotype, characterized by ataxia and disrupted cortical layers...
  66. ncbi Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis
    Petur H Petersen
    Department of Molecular, Cellular and Developmental Biology, Yale University, P O Box 208103, New Haven, Connecticut 06520, USA
    Nat Neurosci 7:803-11. 2004
    ....
  67. ncbi Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction
    Peggy C Stolt
    Department of Pathology, Harvard Medical School, Brigham and Womens Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 280:9671-7. 2005
    Disabled-1 (Dab1) is an essential adaptor protein that functions in the Reelin signaling pathway and is required for the regulation of neuronal migration during embryonic development...
  68. ncbi Expression of coiled-coil protein 1, a novel gene downstream of FGF2, in the developing brain
    Francesca Pellicano
    Beatson Laboratories for Cancer Research, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Gene Expr Patterns 6:285-93. 2006
    ..In situ hybridizations revealed that ccp1 was expressed in the cortical plate between Reelin and Tbr1-positive layers in the dorsal cortex at E15.5. Furthermore, the expression pattern of ccp1 at E13.5-E14...
  69. ncbi Expression of Cux-1 and Cux-2 in the developing somatosensory cortex of normal and barrel-defective mice
    Arnaud Ferrere
    INSERM U616, Hopital de la Pitie Salpetriere, Paris, France
    Anat Rec A Discov Mol Cell Evol Biol 288:158-65. 2006
    ..Conversely, in Reeler mice, Cux-1 and Cux-2 had a distinct laminar distribution: the Cux-1-positive neurons had an inverted deep ..
  70. ncbi Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord
    S A Villeda
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1606, USA
    Neuroscience 139:1385-96. 2006
    Mutations in reeler, the gene coding for the Reelin protein, result in pronounced motor deficits associated with positioning errors (i.e. ectopic locations) in the cerebral and cerebellar cortices...
  71. ncbi Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex
    Toshio Ohshima
    Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Development 134:2273-82. 2007
    ..In addition, proper radial neuronal migration generates an inside-out pattern of cerebral cortex formation and normal axonal trajectories of cortical pyramidal neurons...
  72. pmc Hippocampal dendritic arbor growth in vitro: regulation by Reelin-Disabled-1 signaling
    Sarah A MacLaurin
    Novartis Institutes for BioMedical Research, Inc Cambridge, MA 02139, USA
    Brain Res 1172:1-9. 2007
    The cytoplasmic adaptor protein Disabled-1 (Dab1), which is a key component of the Reelin-signaling pathway, has been suggested to be required for neuronal dendritic development...
  73. pmc Generation of Cajal-Retzius neurons in mouse forebrain is regulated by transforming growth factor beta-Fox signaling pathways
    Julie A Siegenthaler
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Dev Biol 313:35-46. 2008
    ..Specifically, Foxo3a was nuclear in p21+/reelin+ cells in sites of CR neuronal generation, however, nuclear Foxo3a immunoreactivity was absent in p21-/reelin+ ..
  74. pmc Patterns of neurogenesis and amplitude of Reelin expression are essential for making a mammalian-type cortex
    Tadashi Nomura
    Division of Developmental Neuroscience, Center for Translational and Advanced Animal Research CTTAR, Tohoku University School of Medicine, Sendai, Japan
    PLoS ONE 3:e1454. 2008
    ..Furthermore, expression of Reelin gene is hardly detected in the developing avian pallium, and an experimental increase in Reelin-positive cells in ..
  75. doi Chemokine signaling controls intracortical migration and final distribution of GABAergic interneurons
    Guillermina López-Bendito
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 28:1613-24. 2008
    ....
  76. pmc Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling
    Rita De Gasperi
    Research and Development James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Dev Dyn 237:2405-14. 2008
    ..Prior studies have commented on similarities between Psen1-/- and reeler mice. Reelin induces phosphorylation of Dab1 and activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway...
  77. pmc Expression of Disabled 1 suppresses astroglial differentiation in neural stem cells
    Il Sun Kwon
    Department of Anatomy, School of Medicine, Ajou University, Suwon, 443 749, South Korea
    Mol Cell Neurosci 40:50-61. 2009
    Disabled 1 (Dab1), a cytoplasmic adaptor protein expressed predominantly in the CNS, transduces a Reelin-initiated signaling that controls neuronal migration and positioning during brain development...
  78. doi Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3
    Xuejun Chai
    Institut fur Anatomie und Zellbiologie, Albert Ludwigs Universitat Freiburg, D 79104 Freiburg, Germany
    J Neurosci 29:288-99. 2009
    The extracellular matrix protein Reelin, secreted by Cajal-Retzius cells in the marginal zone of the cortex, controls the radial migration of cortical neurons...
  79. doi Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages
    Takayuki Uchida
    Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho ku, Nagoya, Aichi 467 8603, Japan
    J Neurosci 29:10653-62. 2009
    b>Reelin signaling is essential for correct development of the mammalian brain. Reelin binds to apolipoprotein E receptor 2 and very low-density lipoprotein receptor and induces phosphorylation of Dab1...
  80. ncbi Events governing organization of postmigratory neurons: studies on brain development in normal and reeler mice
    A M Goffinet
    Brain Res 319:261-96. 1984
    ..cortex, the cerebellum, the inferior olivary complex and the facial nerve nucleus has been studied in normal and reeler mutant mice, using morphological methods...
  81. ncbi Obstructed migration of Purkinje cells in the developing cerebellum of the reeler mutant mouse
    S Yuasa
    Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
    Anat Embryol (Berl) 188:317-29. 1993
    It has been considered that cortical malformation in the brain of the reeler mutant mouse is due to a defect in the process of neuroblast migration during development...
  82. ncbi The reeler gene encodes a protein with an EGF-like motif expressed by pioneer neurons
    S Hirotsune
    Genome Science Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Nat Genet 10:77-83. 1995
    We have identified a strong candidate cDNA for the mouse reeler gene. This 5 kb transcript encodes a 99.4 kD protein consisting of 881 amino acids and possessing two EGF-like motifs...
  83. ncbi The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons
    M Ogawa
    Department of Physiology, Kochi Medical School, Japan
    Neuron 14:899-912. 1995
    In the neurological mutant mouse reeler, the histological organization of the neocortex develops abnormally and essentially results in an inversion of the relative positions of the cortical layers...
  84. ncbi Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody
    G D'ARCANGELO
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Neurosci 17:23-31. 1997
    The neurological mouse mutant strain reeler displays abnormal laminar organization of several brain structures as a consequence of a defect in cell migration during neurodevelopment...
  85. ncbi Radial glial cell development and transformation are disturbed in reeler forebrain
    K E Hunter-Schaedle
    Laboratory of Developmental Neurobiology, Rockefeller University, New York, New York 10021, USA
    J Neurobiol 33:459-72. 1997
    ..In addition, the neurologic mutant mouse reeler provides a genetic model for analysis of RF60 function...
  86. ncbi Birthdate and cell marker analysis of scrambler: a novel mutation affecting cortical development with a reeler-like phenotype
    J L Gonzalez
    Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 17:9204-11. 1997
    The reeler mutation in mice produces an especially well characterized disorder, with systematically abnormal migration of cerebral cortical neurons...
  87. ncbi A truncated Reelin protein is produced but not secreted in the 'Orleans' reeler mutation (Reln[rl-Orl])
    V de Bergeyck
    Department of Physiology, FUNDP Medical School, Namur, Belgium
    Brain Res Mol Brain Res 50:85-90. 1997
    b>Reelin is the protein defective in reeler mutant mice [I. Bar, C. Lambert de Rouvroit, I. Royaux, D.B. Krizman, C. Dernoncourt, D. Ruelle, M.C. Beckers, A.M...
  88. ncbi Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain
    D S Rice
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Development 125:3719-29. 1998
    Mutation of either reelin (Reln) or disabled-1 (Dab1) results in widespread abnormalities in laminar structures throughout the brain and ataxia in reeler and scrambler mice...
  89. pmc Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 USA
    Genes Dev 13:643-8. 1999
    The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein...
  90. ncbi Reelin, the extracellular matrix protein deficient in reeler mutant mice, is processed by a metalloproteinase
    C Lambert de Rouvroit
    Neurobiology Unit, University of Namur Medical School, 61 rue de Bruxelles, B 5000 Namur, Belgium
    Exp Neurol 156:214-7. 1999
    b>Reelin is the extracellular protein defective in reeler mice. It is believed that reelin acts via the extracellular matrix to influence the development of nearby neurons, but the mechanism remains thus far unknown...
  91. ncbi The phenotypic characteristics of heterozygous reeler mouse
    P Tueting
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, 60612, USA
    Neuroreport 10:1329-34. 1999
    Histological and behavioral traits are associated with reelin (Reln) haplo-insufficiency in heterozygous reeler mouse (rl+/-)...
  92. ncbi Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2
    M Trommsdorff
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235 9046, USA
    Cell 97:689-701. 1999
    Layering of neurons in the cerebral cortex and cerebellum requires Reelin, an extracellular matrix protein, and mammalian Disabled (mDab1), a cytosolic protein that activates tyrosine kinases...
  93. pmc Reelin controls position of autonomic neurons in the spinal cord
    J W Yip
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 97:8612-6. 2000
    ..Thus, the Reln product, reelin, is thought to control cell-cell interactions critical for cell positioning in the brain...
  94. pmc Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse
    W S Liu
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 98:3477-82. 2001
    Heterozygous reeler mice (HRM) haploinsufficient for reelin express approximately 50% of the brain reelin content of wild-type mice, but are phenotypically different from both wild-type mice and homozygous reeler mice...
  95. ncbi The reelin pathway modulates the structure and function of retinal synaptic circuitry
    D S Rice
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Neuron 31:929-41. 2001
    ..Here, we demonstrate that two essential genes in the Reelin signaling pathway function during the patterning of synaptic connectivity in the retina...
  96. pmc Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons
    Yoshinobu Sugitani
    Department of Cell Biology, JFCR Cancer Institute, Tokyo 170 8455, Japan
    Genes Dev 16:1760-5. 2002
    ..These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development...
  97. pmc Reelin, Disabled 1, and beta 1 integrins are required for the formation of the radial glial scaffold in the hippocampus
    Eckart Forster
    Anatomisches Institut, Universitat Freiburg, P O Box 111, D 79001 Freiburg, Germany
    Proc Natl Acad Sci U S A 99:13178-83. 2002
    The extracellular matrix molecule Reelin is required for the correct positioning of neurons during the development of the forebrain. However, the mechanism of Reelin action on neuronal migration is poorly understood...
  98. ncbi Reelin activates SRC family tyrosine kinases in neurons
    Hans H Bock
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 75390, Dallas, TX, USA
    Curr Biol 13:18-26. 2003
    b>Reelin is a large signaling molecule that regulates the positioning of neurons in the mammalian brain...
  99. pmc A reelin-integrin receptor interaction regulates Arc mRNA translation in synaptoneurosomes
    Erbo Dong
    Psychiatric Institute, Department of Psychiatry, University of Illinois, College of Medicine, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 100:5479-84. 2003
    ..In heterozygous reeler mice, reelin bound to DSPSD, and the expression of Arc (activity-regulated cytoskeletal protein) is lower than in ..
  100. ncbi Ectopic corticospinal tract and corticothalamic tract neurons in the cerebral cortex of yotari and reeler mice
    Tatsuro Yamamoto
    Division of Anatomy and Developmental Neurobiology, Department of Neuroscience, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    J Comp Neurol 461:61-75. 2003
    Reeler and yotari mice, which are mutant for Reelin or Dab1, respectively, show disorders of cerebral cortical lamination...
  101. ncbi CXCR4 regulates interneuron migration in the developing neocortex
    Ralf K Stumm
    Department of Pharmacology and Toxicology, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:5123-30. 2003
    ..Thus, our findings suggest that SDF-1, which is highly expressed in the embryonic leptomeninx, selectively regulates migration and layer-specific integration of CXCR4-expressing interneurons during neocortical development...

Research Grants13

  1. EPILEPTOGENESIS IN THE AGED CNS
    Peter Patrylo; Fiscal Year: 2002
    ..Thus, by examining synaptic reorganization within the aged CNS they may also provide insight into the basic mechanisms of epilepsy and learning and memory within the overall population. ..
  2. Synapase Modification /Memory Retention /Life Span Model
    Peter Patrylo; Fiscal Year: 2002
    ..abstract_text> ..
  3. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..cortex of control (same age) embryos, heterochronic (different age) embryos, or Rein mutant embryos, which lack Reelin and have a disorganized cortex...
  4. APO E Receptors and Modulation of Fast Axonal Transport
    Joachim Herz; Fiscal Year: 2006
    ..b>Reelin, a large secreted protein that bears no resemblance to lipoproteins and is not involved in lipid transport, binds ..
  5. STRUCTURAL AND FUNCTIONAL ANALYSES OF NEURONAL PTPS
    Paul Lombroso; Fiscal Year: 2008
    ..STEP knock-out mice will also be characterized. The proposed investigations will be done in the supportive environment of the Child Study Center with its commitment to cliniclaly informed basic science research. ..
  6. METABOLISM OF THE VLDL RECEPTOR AND APOE RECEPTOR 2
    Joachim Herz; Fiscal Year: 2009
    ..This may provide novel targets for rational drug design and treatment of atherosclerosis as well as of AD, both disorders of increasing medical and socio-economic importance. ..
  7. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2001
    ..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
  8. MOLECULAR CONTROL OF CELL MIGRATION IN THE SPINAL CORD
    JOSEPH YIP; Fiscal Year: 2004
    ..A gene that has been found to influence neuronal migration in the brain of the mouse is the reeler gene (reln)...
  9. Role of the JIP-1-p190RhoGEF Complex In Neuron Function
    WILLIAM ARTHUR; Fiscal Year: 2004
    ..Of these receptors, ApoER2 performs a crucial role in brain development as a receptor for Reelin, a protein that is secreted in specific regions of the brain and guides neuronal migrations...
  10. Investigating the nature of prestin-associated proteins
    Jing Zheng; Fiscal Year: 2007
    ..This knowledge may make it possible to manipulate OHC function for therapeutic purposes. ..
  11. Molecular Mechanisms of Thalamocortical Development
    NOELLE DWYER; Fiscal Year: 2008
    ..Combining the expertise in mouse genetics with the previous training in mouse neuroanatomy and nematode genetics will significantly add to the Candidate's potential to make a strong impact on the field. ..
  12. The PTP, STEP, Regulates Amphetamine Actions
    Paul Lombroso; Fiscal Year: 2008
    ..We show preliminary feasibility data on this approach. A complementary set of experiments will study the STEP knock-out mouse that we predict is hypersensitive to stimulant treatment. ..
  13. Biological Role of the FE65 Protein/APP Interactions
    Suzanne Guenette; Fiscal Year: 2009
    ..In addition, we will gain insight into the role of the FE65 proteins in cellular signaling events that are critical for brain function. ..