Rela

Summary

Gene Symbol: Rela
Description: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Alias: p65, avian reticuloendotheliosis viral (v-rel) oncogene homolog A, nuclear factor NF-kappa-B p65 subunit, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 NF kappaB, p65 NF-kappa B, p65 NFkB, transcription factor p65
Species: mouse

Top Publications

  1. ncbi Members of the NF-kappaB family expressed in zones of active neurogenesis in the postnatal and adult mouse brain
    Suzanne Denis-Donini
    Department of Biology, Section of Zoology and Cytology, University of Milan, Milan, Italy
    Brain Res Dev Brain Res 154:81-9. 2005
  2. ncbi Heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor
    Sachiye Inouye
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Japan
    J Biol Chem 282:33210-7. 2007
  3. pmc Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB
    Xiao Dong Yang
    Department of Biochemistry, College of Medicine, MC 714, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Mol Cell Biol 30:2170-80. 2010
  4. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
  5. pmc Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination
    Hui Geng
    Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus Liebig University, D 35392 Giessen, Germany
    EMBO Rep 10:381-6. 2009
  6. pmc Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:3910-8. 2003
  7. pmc Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65
    Christine Buerki
    Institute of Veterinary Biochemistry and Molecular Biology, 8057 Zurich, Switzerland
    Nucleic Acids Res 36:1665-80. 2008
  8. ncbi An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 274:782-4. 1996
  9. pmc The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50
    Christine S Cheng
    Signaling Systems Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Sci Signal 4:ra11. 2011
  10. doi Coactivator function of RIP140 for NFkappaB/RelA-dependent cytokine gene expression
    Inka Zschiedrich
    Emmy Noether and Marie Curie Research Group Molecular Metabolic Control, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Blood 112:264-76. 2008

Detail Information

Publications139 found, 100 shown here

  1. ncbi Members of the NF-kappaB family expressed in zones of active neurogenesis in the postnatal and adult mouse brain
    Suzanne Denis-Donini
    Department of Biology, Section of Zoology and Cytology, University of Milan, Milan, Italy
    Brain Res Dev Brain Res 154:81-9. 2005
    ..Their presence in actively proliferating progenitor cells, detected by BrdU staining, further suggests that NF-kappaB may be part of a signaling pathway that is important for neurogenesis...
  2. ncbi Heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor
    Sachiye Inouye
    Department of Biochemistry and Molecular Biology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube, Japan
    J Biol Chem 282:33210-7. 2007
    ..These results indicate that HSF1 partially opens the chromatin structure of the IL-6 promoter for an activator or a repressor to bind to it, and provides a novel mechanism of gene regulation by HSF1...
  3. pmc Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB
    Xiao Dong Yang
    Department of Biochemistry, College of Medicine, MC 714, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Mol Cell Biol 30:2170-80. 2010
    Posttranslational modifications of the RelA subunit of NF-kappaB, including acetylation and methylation, play a key role in controlling the strength and duration of its nuclear activity...
  4. pmc NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
    Florian R Greten
    Second Department of Medicine, Klinikum rechts der Isar, Technical University Munich, 81675 Germany
    Cell 130:918-31. 2007
    ..These results unravel an unanticipated role for IKKbeta-dependent NF-kappaB signaling in the negative control of IL-1beta production and highlight potential complications of long-term IKKbeta inhibition...
  5. pmc Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination
    Hui Geng
    Institute of Biochemistry, Medical Faculty, Friedrichstrasse 24, Justus Liebig University, D 35392 Giessen, Germany
    EMBO Rep 10:381-6. 2009
    ..phosphorylation/ubiquitination switch in the NF-kappaB network that controls the stability of the transactivating p65 subunit...
  6. pmc Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:3910-8. 2003
    ..zeta protein kinase C (PKC)-deficient cells, NF-kappaB is transcriptionally inactive and the phosphorylation of the RelA subunit in response to tumor necrosis factor (TNF-alpha) is severely impaired...
  7. pmc Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65
    Christine Buerki
    Institute of Veterinary Biochemistry and Molecular Biology, 8057 Zurich, Switzerland
    Nucleic Acids Res 36:1665-80. 2008
    ..We show here in vitro and in vivo acetylation of RelA/p65 by p300 on lysine 314 and 315, two novel acetylation sites...
  8. ncbi An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 274:782-4. 1996
    ..In particular, the RelA (p65) subunit is required for induction of tumor necrosis factor-alpha (TNF-alpha)-dependent genes...
  9. pmc The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50
    Christine S Cheng
    Signaling Systems Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Sci Signal 4:ra11. 2011
    ....
  10. doi Coactivator function of RIP140 for NFkappaB/RelA-dependent cytokine gene expression
    Inka Zschiedrich
    Emmy Noether and Marie Curie Research Group Molecular Metabolic Control, German Cancer Research Center Heidelberg, Heidelberg, Germany
    Blood 112:264-76. 2008
    ..for cytokine gene promoter activity relies on direct protein-protein interactions with the NFkappaB subunit RelA and histone acetylase cAMP-responsive element binding protein (CREB)-binding protein (CBP)...
  11. ncbi The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1
    Haihong Zhong
    Immunobiology Section and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Mol Cell 9:625-36. 2002
    ..now demonstrate that transcriptionally inactive nuclear NF-kappaB in resting cells consists of homodimers of either p65 or p50 complexed with the histone deacetylase HDAC-1...
  12. pmc Two modes of transcriptional activation at native promoters by NF-kappaB p65
    Dominic van Essen
    Max Planck Institute for Immunobiology, Freiburg, Germany
    PLoS Biol 7:e73. 2009
    ..To dissect NF-kappaB-driven transcription at native promoters, we disrupted the interaction between NF-kappaB p65 and the Mediator complex...
  13. ncbi Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding
    Geoffrey Gloire
    GIGA Research, Virology Immunology, and Medical Chemistry Units, University of Liege, B 4000 Liege, Belgium
    J Biol Chem 282:21308-18. 2007
    ..and reexpressing IKKalpha after retroviral transduction, we demonstrate that IKKalpha contributes to NF-kappaB/p65 DNA binding activity on an exogenous kappaB element and on some, but not all, endogenous NF-kappaB-target promoters...
  14. pmc Pancreas-specific RelA/p65 truncation increases susceptibility of acini to inflammation-associated cell death following cerulein pancreatitis
    Hana Algül
    Second Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    J Clin Invest 117:1490-501. 2007
    ..Here we studied the role of RelA/p65, the main transactivating subunit, during acute pancreatitis using a Cre-loxP strategy...
  15. pmc Tumor necrosis factor-alpha induces RelA degradation via ubiquitination at lysine 195 to prevent excessive nuclear factor-kappaB activation
    Yihui Fan
    Department of Pediatrics, Texas Children s Cancer Center, Houston, TX 77030, USA
    J Biol Chem 284:29290-7. 2009
    Ubiquitination-mediated degradation of the RelA subunit of nuclear factor-kappaB (NF-kappaB) is critical for the termination of NF-kappaB activation...
  16. ncbi IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation
    Toby Lawrence
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, California 92093, USA
    Nature 434:1138-43. 2005
    ..contributes to suppression of NF-kappaB activity by accelerating both the turnover of the NF-kappaB subunits RelA and c-Rel, and their removal from pro-inflammatory gene promoters...
  17. ncbi NF-kappa B: ten years after
    P A Baeuerle
    Tularik Inc, South San Francisco, California 94080, USA
    Cell 87:13-20. 1996
  18. pmc Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation
    John M O'Shea
    Department of Cellular and Molecular Medicine, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Biochem J 426:345-54. 2010
    Phosphorylation of the RelA (p65) NF-kappaB (nuclear factor kappaB) subunit has been previously shown to modulate its ability to induce or repress transcription...
  19. ncbi IKKbeta phosphorylates p65 at S468 in transactivaton domain 2
    Robert F Schwabe
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York, USA
    FASEB J 19:1758-60. 2005
    The transcription factor nuclear factor-kappa B (NF-kappaB) subunit p65 is phosphorylated by IkappaB kinase (IKK) at S536 in transactivation domain (TAD) 1. In this study, we investigate the presence of IKK sites in TAD2 of p65...
  20. ncbi Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B
    Kirsteen J Campbell
    School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Cell 13:853-65. 2004
    ..Surprisingly, these effects are mediated by the RelA(p65) NF-kappa B subunit...
  21. ncbi cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B
    Josef Anrather
    Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 280:244-52. 2005
    ..b>RelA(-/-) mouse embryonic fibroblasts reconstituted with wild-type p65 or p65 phosphorylation-deficient mutants showed a ..
  22. pmc IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis
    Nadine Bakkar
    Human Cancer Genetics Program, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA
    J Cell Biol 180:787-802. 2008
    ..We find that myogenesis is enhanced in MyoD-expressing fibroblasts deficient in classical pathway components RelA/p65, inhibitor of kappaB kinase beta (IKKbeta), or IKKgamma...
  23. pmc Nucling mediates apoptosis by inhibiting expression of galectin-3 through interference with nuclear factor kappaB signalling
    Li Liu
    The Institute for Enzyme Research, The University of Tokushima, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Biochem J 380:31-41. 2004
    ..Nucling was shown to interfere with NF-kappaB activation via the nuclear translocation process of NF-kappaB/p65, thus inhibiting the expression of galectin-3...
  24. ncbi Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 376:167-70. 1995
    NF-kappa B, which consists of two polypeptides, p50 (M(r) 50K) and p65/RelA (M(r) 65K), is thought to be a key regulator of genes involved in responses to infection, inflammation and stress...
  25. ncbi Nuclear factor kappaB nuclear translocation as a crucial marker of brain response to interleukin-1. A study in rat and interleukin-1 type I deficient mouse
    Agnes Nadjar
    INRA INSERM U 394, Institut F Magendie, Bordeaux, France
    J Neurochem 87:1024-36. 2003
    ..that IL-1RI expressed in blood brain barrier (BBB) cells and in circumventricular organs (CVOs) is crucial for p65-NFkappaB translocation induced by peripheral injection of IL-1beta...
  26. ncbi p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1
    Jan Bohuslav
    Gladstone Institute of Virology and Immunology and the Department of Medicine, University of California, San Francisco, California 94143 1234, USA
    J Biol Chem 279:26115-25. 2004
    ..expression stimulates the serine/threonine kinase ribosomal S6 kinase 1 (RSK1), which in turn phosphorylates the p65 subunit of NF-kappaB...
  27. ncbi An atypical NF-kappa B-regulated pathway mediates phorbol ester-dependent heme oxygenase-1 gene activation in monocytes
    Srivatsava Naidu
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Immunol 181:4113-23. 2008
    ..This HO-kappaB element was a nuclear target for the NF-kappaB subunit p65/RelA as determined by nuclear binding assays and transfection experiments with luciferase reporter gene constructs in ..
  28. ncbi A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice
    Bruce J Herron
    Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 14:667-77. 2005
    ..A C-terminal fragment of this protein was previously identified as the RelA associated inhibitor (RAI)...
  29. pmc Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation
    Vanesa Esteban
    Cellular Biology in Renal Diseases Laboratory, Fundacion Jimenez Diaz, Universidad Autonoma Madrid, Madrid, Spain
    PLoS ONE 4:e5406. 2009
    ..Therefore, the blockade of the NF-kappaB-activating properties of the receptor Mas could be a new strategy in the therapy of failing kidney...
  30. pmc Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction
    Mourad Zerfaoui
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Cell Signal 20:186-94. 2008
    ..Here we show that while p65 NF-kappaB nuclear translocation in TNF-treated smooth muscle cells (SMCs) was sufficient for the expression of VCAM-..
  31. ncbi Distinct roles of different NF-kappa B subunits in regulating inflammatory and T cell stimulatory gene expression in dendritic cells
    Junmei Wang
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Immunol 178:6777-88. 2007
    ..g., TNF-alpha, IL-1alpha, and IL-6). In striking contrast, the RelA subunit was crucial for expression of inflammatory cytokine genes but not T cell stimulatory genes...
  32. pmc Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease
    Jie Dong
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Genes Dev 24:1709-17. 2010
    ..of NF-kappaB in inflammation, we created a knock-in mouse that expresses a constitutively active form of NF-kappaB p65 dimers...
  33. ncbi Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
    Y Hu
    Department of Pharmacology, Cancer Center, University of California San Diego, La Jolla, CA 92093 0636, USA
    Science 284:316-20. 1999
    ..Instead, loss of IKKalpha interfered with multiple morphogenetic events, including limb and skeletal patterning and proliferation and differentiation of epidermal keratinocytes...
  34. pmc The combined absence of the transcription factors Rel and RelA leads to multiple hemopoietic cell defects
    M Grossmann
    The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 96:11848-53. 1999
    ..Redundancy among these proteins prompted us to examine the role of Rel and RelA in hemopoiesis by using mice that lack both subunits. Because of the death of double-mutant fetuses at day 13...
  35. ncbi Limb and skin abnormalities in mice lacking IKKalpha
    K Takeda
    Department of Biochemistry and Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Department of Pathology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Science 284:313-6. 1999
    ....
  36. ncbi Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65
    ALISON M O'MAHONY
    Gladstone Institute for Virology and Immunology, Department of Medicine, University of California, San Francisco, California 94141, USA
    J Biol Chem 279:18137-45. 2004
    ..the defect in NF-kappaB action in IKK1(-/-) cells correlated with a failure of Tax to induce phosphorylation of the RelA/p65 subunit of NF-kappaB at Ser(529) and Ser(536)...
  37. pmc RelA/p65 regulation of IkappaBbeta
    Erin Hertlein
    Human Cancer Genetics Program, The Ohio State University, Columbus, OH, USA
    Mol Cell Biol 25:4956-68. 2005
    ..Here, we describe in detail the regulation of IkappaBbeta by RelA/p65...
  38. ncbi Bim and Noxa are candidates to mediate the deleterious effect of the NF-kappa B subunit RelA in cerebral ischemia
    Ioana Inta
    Department of Neurology, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 26:12896-903. 2006
    ..focal cerebral ischemia in mice with a germline deletion of the p52 or c-Rel gene or with a conditional deletion of RelA in the brain. Only RelA deficiency reduced infarct size...
  39. pmc The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury
    A Lanzillotta
    Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, Istituto Nazionale di Neuroscienze Brescia, Italy
    Cell Death Dis 1:e96. 2010
    The activation of nuclear factor kappa B (NF-κB) p50/RelA is a key event in ischemic neuronal injury, as well as in brain ischemic tolerance...
  40. ncbi Constitutive and inducible Rel/NF-kappa B activities in mouse thymus and spleen
    F Weih
    Department of Molecular Biology, Bristol Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543 4000
    Oncogene 9:3289-97. 1994
    ..Although RelB protein is present at significantly lower levels in thymus and spleen extracts when compared to RelA, in both tissues the predominant kappa B-binding activity consists of p50/RelB and p52/RelB heterodimers and only ..
  41. ncbi Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro
    Fabian Geisler
    Second Department of Internal Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich
    Gastroenterology 132:2489-503. 2007
    ..response to tumor necrosis factor (TNF)-alpha during development because mice deficient for the NF-kappaB subunit RelA/p65 die in utero because of TNF-induced liver apoptosis...
  42. pmc c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells
    Iwao Isomura
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 206:3001-14. 2009
    ..Collectively, our results indicate that c-Rel is important for both the thymic development and peripheral homeostatic proliferation of T reg cells...
  43. doi GFP-p65 knock-in mice as a tool to study NF-kappaB dynamics in vivo
    Rossana De Lorenzi
    Institute for Genetics, Centre for Molecular Medicine, and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Germany
    Genesis 47:323-9. 2009
    ..we generated knock-in mice expressing a fusion protein between the green fluorescent protein (GFP) and the p65/RelA NF-kappaB subunit (GFP-p65) from the endogenous p65 genomic locus...
  44. pmc Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications
    Hongwei Yao
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:5405-16. 2010
    ..The mechanism underlying these findings is associated with decreased RelA/p65 phosphorylation (Ser(311)) and translocation of the RelA/p65 subunit of NF-kappaB into the nucleus...
  45. doi p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
    Keiko Kawauchi
    Department of Molecular Oncology, Institute of Gerontology, Nippon Medical School, Kosugi cho 1 396, Nakahara ku, Kawasaki shi, Kanagawa 211 8533, Japan
    Nat Cell Biol 10:611-8. 2008
    ..cell transformation and acceleration of aerobic glycolysis in p53-deficient cells were suppressed in the absence of p65/NF-kappaB expression, and were restored by GLUT3 expression...
  46. ncbi Dendritic cell development and survival require distinct NF-kappaB subunits
    Fateh Ouaaz
    Columbia University, Department of Biological Sciences, 1110 Fairchild Center, 1212 Amsterdam Avenue, New York, NY 10027, USA
    Immunity 16:257-70. 2002
    ..Here, we have studied DCs from mice deficient in the p50, RelA, and cRel subunits of the immunomodulatory NF-kappaB transcription factor...
  47. pmc Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor
    Carl Y Sasaki
    Laboratory of Immunology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 286:1093-102. 2011
    ..The LTβ priming process was not due to an increase in TNF-mediated nuclear translocation of p65, p65 DNA binding, or NF-κB transactivational activity...
  48. ncbi Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts
    S Gerondakis
    The Walter and Eliza Hall Institute of Medical Research, Post Office, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Oncogene 18:6888-95. 1999
    ..One exception is rela, which is essential for embryonic liver development...
  49. ncbi Induction of activator protein-1 and nuclear factor-kappaB as a prerequisite for disease development in susceptible SJL/J mice after theiler murine encephalomyelitis
    Ingo Gerhauser
    Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany
    J Neuropathol Exp Neurol 66:809-18. 2007
    ..The expression of activator protein-1 (c-fos and c-jun) and nuclear factor-kappaB (p50 and p65) genes, TME virus, tumor necrosis factor-alpha, and interferon-gamma was investigated in the spinal cord of TME ..
  50. pmc Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway
    D Gregory
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599 7290, USA
    J Virol 78:13582-90. 2004
    ..Infected MEFs were assayed for virus yield, loss of IkappaBalpha, nuclear translocation of p65, and NFkappaB DNA-binding activity...
  51. ncbi Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1
    Ryan M O'Connell
    Department of Microbiology, Immunology and Molecular Genetics, University of California, CA 90095, USA
    J Immunol 174:1602-7. 2005
    ..Additionally, we provide evidence that both the LM- and TLR-dependent pathways converge at TBK1 to activate type I IFNs, highlighting the central role of this molecule in modulating type I IFNs in host defense and disease...
  52. pmc Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA
    Bo Huang
    Department of Biochemistry, College of Medicine, MC 714, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Mol Cell Biol 29:1375-87. 2009
    Acetylation of the RelA subunit of NF-kappaB, especially at lysine-310, is critical for the transcriptional activation of NF-kappaB and the expression of inflammatory genes...
  53. ncbi NF-kappaB activation in premalignant mouse tal-1/scl thymocytes and tumors
    Jennifer O'Neil
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, USA
    Blood 102:2593-6. 2003
    ..Moreover, nuclear p65/p50 heterodimers are detected in premalignant tal-1/scl and mut tal-1/scl thymocytes, suggesting that E2A depletion ..
  54. doi Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice
    Eriko Aoki
    Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan
    Exp Mol Pathol 86:57-64. 2009
    ..In this study, we investigated the time course changes of NF-kappaB (Nuclear factor kappa B) p65 protein and apoptosis in the substantia nigra after MPTP treatment in mice...
  55. doi Gamma-linolenic acid inhibits inflammatory responses by regulating NF-kappaB and AP-1 activation in lipopolysaccharide-induced RAW 264.7 macrophages
    Cheng Sue Chang
    Department of Neurology, Changhua Christian Hospital, Changhua City, Changhua County, Taiwan
    Inflammation 33:46-57. 2010
    ..treatments dramatically inhibited LPS-induced IkappaB-alpha degradation, IkappaB-alpha phosphorylation, and nuclear p65 protein expression...
  56. pmc Repression of gene expression by unphosphorylated NF-kappaB p65 through epigenetic mechanisms
    Jie Dong
    Department of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genes Dev 22:1159-73. 2008
    Cells from a "knock-in" mouse expressing a NF-kappaB p65 mutant bearing an alanine instead of serine at position 276 (S276A) display a significant reduction of NF-kappaB-dependent transcription, even though the mutant p65 forms ..
  57. ncbi Lack of essential role of NF-kappa B p50, RelA, and cRel subunits in virus-induced type 1 IFN expression
    Xingyu Wang
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Immunol 178:6770-6. 2007
    ..expression was strongly induced following virus infection of mouse embryonic fibroblasts (MEFs) from p50(-/-), RelA/p65(-/-), cRel(-/-), p50(-/-)cRel(-/-), and p50(-/-)RelA(-/-) mice...
  58. ncbi Polyinosinic acid induces TNF and NO production as well as NF-kappaB and AP-1 transcriptional activation in the monocytemacrophage cell line RAW 264.7
    V M Campa
    Instituto Universitario de Oncología del Principado de Asturias and Departamento de Bioquímica y Biología Molecular, Universidad de Oviedo, 33071 Oviedo, Spain
    Inflamm Res 54:328-37. 2005
    ..This study evaluates the poly inosinic acid (poly I)-induced activation in the murine monocytemacrophage cell line RAW 264.7, which led to an inflammatory phenotype...
  59. ncbi The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages
    Daniela De Stefano
    Dipartimento di Farmacologia Sperimentale, via D Montesano 49, University of Naples Federico II, 80131 Naples, Italy
    J Mol Med (Berl) 84:65-74. 2006
    ..7 cells can be ascribed to all three transcription factors, may contribute to lead to new insights into the molecular mechanisms governing the inflammatory process in celiac disease...
  60. ncbi IRF-1 and NF-kappaB p50/cRel bind to distinct regions of the proximal murine IL-12 p35 promoter during costimulation with IFN-gamma and LPS
    Jutta I Kollet
    Department of Oral Biology and the Nebraska Center for Virology, University of Nebraska Medical Center, Lincoln, NE 68583 0740, USA
    Mol Immunol 43:623-33. 2006
    ..Thus, cRel with IRF-1 induce p35 expression through a small region of the p35 exon 2 promoter during IFN-gamma and LPS costimulation of macrophages...
  61. pmc NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
    T S Doi
    Laboratory of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Exp Med 185:953-61. 1997
    To investigate the function of NF-kappa B RelA (p65), we generated mice deficient in this NF-kappa B family member by homologous recombination. Mice lacking RelA showed liver degeneration and died around embryonic day 14.5...
  62. ncbi Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment
    E Alcamo
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 167:1592-600. 2001
    ..b>RelA-deficient mice die on embryonic day 15 from TNF-alpha-induced liver degeneration...
  63. ncbi Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:7370-7. 2004
    ..Interactions of HMGB1 with TLR 2 and TLR 4 may provide an explanation for the ability of HMGB1 to generate inflammatory responses that are similar to those initiated by LPS...
  64. pmc Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1
    Jianguo Liu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Exp Med 198:1265-76. 2003
    ..Thus, IRF-1 acts as a critical component of IFN-gamma signaling in the selective activation of IL-12 p35 transcription in synergy with LPS-mediated events...
  65. pmc NF-kappaB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
    Raquel Sitcheran
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Genes Dev 17:2368-73. 2003
    ..Thus, in response to cytokine signaling, NF-kappaB modulates the differentiation of mesenchymal-derived cell lineages via RNA sequence-dependent, posttranscriptional down-regulation of key developmental regulators...
  66. ncbi NF-kappa B functions in synaptic signaling and behavior
    Mollie K Meffert
    Division of Biology, MC204 31 California Institute of Technology, Pasadena, California 91125, USA
    Nat Neurosci 6:1072-8. 2003
    ..The p65:p50 NF-kappa B form is selectively localized at synapses; p65-deficient mice have no detectable synaptic NF-kappa B...
  67. ncbi Communication between NF-kappa B and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene
    Gunther H Boekhoudt
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 170:4139-47. 2003
    ..assays identified changes in response to TNF at both the proximal and distal regions that were dependent on the p65 subunit of NF-kappaB and Sp1...
  68. ncbi c-Rel is required for chromatin remodeling across the IL-2 gene promoter
    Sudha Rao
    Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Immunol 170:3724-31. 2003
    ..that IL-2 gene transcription in CD4(+) primary T cells is dependent on the NF-kappaB family member, c-Rel, but not RelA. We found that c-Rel is essential for global changes in chromatin structure across the 300-bp IL-2 promoter in ..
  69. pmc c-Rel regulates interleukin 12 p70 expression in CD8(+) dendritic cells by specifically inducing p35 gene transcription
    R Grumont
    The Walter and Eliza Hall Institute of Medical Research, The Royal Melbourne Hospital, Victoria 3050, Australia
    J Exp Med 194:1021-32. 2001
    ....
  70. ncbi Notch-1 regulates NF-kappaB activity in hemopoietic progenitor cells
    P Cheng
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    J Immunol 167:4458-67. 2001
    ..HPC from Notch-AS-Tg mice have decreased levels of several members of the NF-kappaB family, p65, p50, RelB, and c-Rel and this is due to down-regulation of the gene expression...
  71. ncbi Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation
    I M Verma
    Laboratory of Genetics, Salk Institute, San Diego, California 92186 5800, USA
    Genes Dev 9:2723-35. 1995
  72. ncbi Nuclear translocation of nuclear factor kappa B in early 1-cell mouse embryos
    A Nishikimi
    Laboratory of Reproductive Physiology, Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Biol Reprod 60:1536-41. 1999
    ..In this study, we show that RelA, one of the subunits of NF-kappaB, is expressed in mouse eggs and embryos from the metaphase II (MII) oocyte to the ..
  73. pmc Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
    T S Doi
    Laboratory of Immunology, Aichi Cancer Center Research Institute, Nagoya 464, Japan
    Proc Natl Acad Sci U S A 96:2994-9. 1999
    Mice lacking the RelA (p65) subunit of NF-kappaB die between days 14 and 15 of embryogenesis because of massive liver destruction...
  74. pmc An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis
    T Hettmann
    Departments of Medicine and Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Exp Med 189:145-58. 1999
    ..In addition, NF-kappaB is required for the alpha-CD3-mediated apoptosis of DP thymocytes through a pathway that involves the regulation of the antiapoptotic gene, bcl-xL...
  75. ncbi The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation
    T Huxford
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093 0359, USA
    Cell 95:759-70. 1998
    ..The 2.3 A crystal structure of IkappaBalpha in complex with the NF-kappaB p50/p65 heterodimer reveals mechanisms of these inhibitory activities...
  76. ncbi Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA
    F E Chen
    Department of Biology, University of California, San Diego, La Jolla 92093 0359, USA
    Nature 391:410-3. 1998
    The NF-kappaB p50/p65 heterodimer is the classical member of the Rel family of transcription factors which regulate diverse cellular functions such as immune response, cell growth, and development...
  77. pmc NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK
    Jennifer Y Zhang
    VA Palo Alto Healthcare System, Palo Alto, California 94305, USA
    Genes Dev 18:17-22. 2004
    ..Embryonic lethality of mice lacking NF-kappaB RelA has hindered efforts to address this. We therefore generated developmentally mature RelA(-/-) skin...
  78. pmc Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways
    Brian Zarnegar
    Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8108-13. 2004
    ..Interestingly, significant CD40-induced B cell survival is still observed even in p50(-/-)c-Rel(-/-)p65(-/+) B cells, which is correlated with the ability of CD40L to up-regulate Bcl-x(L) expression in these cells...
  79. ncbi Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita Osaka, Japan
    Nature 430:218-22. 2004
    ....
  80. ncbi The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3
    B H Horwitz
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Immunol 162:1941-6. 1999
    ..We generated small resting B cells lacking p65 or p50 alone, or lacking both p50 and p65, then evaluated the ability of these cells to proliferate, secrete Ig, ..
  81. ncbi NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    Tomohiro Watanabe
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Room 11N238, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Immunol 5:800-8. 2004
    ..Thus, CARD15 mutations may lead to disease by causing excessive T(H)1 responses...
  82. pmc The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms
    Raffi Gugasyan
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Mol Cell Biol 24:5733-45. 2004
    ..has been limited by redundancy among these proteins and by embryonic lethality associated with the absence of RelA. Using mice lacking RelA and c-rel, which survive throughout embryogenesis on a tumor necrosis factor alpha (TNF-..
  83. pmc A fourth IkappaB protein within the NF-kappaB signaling module
    Soumen Basak
    Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 128:369-81. 2007
    Inflammatory NF-kappaB/RelA activation is mediated by the three canonical inhibitors, IkappaBalpha, -beta, and -epsilon...
  84. pmc Nuclear factor kappa B is required for the development of marginal zone B lymphocytes
    A Cariappa
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02129, USA
    J Exp Med 192:1175-82. 2000
    ..Reconstitution of B cells in Rag-2(-/-) mice with a mixture of p50(-/-)/p65(-/-) fetal liver cells and Rag-2(-/-) bone marrow cells revealed that the generation of marginal zone B cells ..
  85. ncbi DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide
    G P Nolan
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142
    Cell 64:961-9. 1991
    The sequence and biochemical properties of the product of the cloned cDNA for the p65 subunit of nuclear factor kappa B (NF-kappa B) have been determined...
  86. ncbi The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-kappaB-dependent c-myc expression
    Raelene Grumont
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Immunity 21:19-30. 2004
    ..Here, we show that c-myc-dependent growth during T cell activation requires c-Rel and RelA and that blocking this growth by inhibiting protein kinase C theta (PKCtheta) coincides with a failure to ..
  87. pmc Expression of MIS in the testis is downregulated by tumor necrosis factor alpha through the negative regulation of SF-1 transactivation by NF-kappa B
    Cheol Yi Hong
    Hormone Research Center, Chonnam National University, Gwangju 500 757, Republic of Korea
    Mol Cell Biol 23:6000-12. 2003
    ..These results may identify, for the first time, the responsible substance and its action mechanism underlying the repression of MIS expression by meiotic germ cells in the testis...
  88. doi Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development
    Taku Saito
    Sensory and Motor System Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Nat Med 16:678-86. 2010
    ..The EPAS1 promoter assay identified RELA, a nuclear factor-kappaB (NF-kappaB) family member, as a potent inducer of HIF-2alpha expression...
  89. pmc Ca2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta
    Angela M Bair
    Department of Pharmacology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 284:563-74. 2009
    ..We observed that thrombin-induced p65/RelA, AMPK, and PKCdelta activation were markedly reduced by knockdown of the TRPC isoform TRPC1 expressed in human ..
  90. doi Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells
    Sivakumar Vallabhapurapu
    Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany
    Eur J Immunol 38:3508-19. 2008
    ..Here, we show that the Rel/NF-kappaB family member RelA regulates the NK1.1(-) to NK1.1(+) transition during NKT-cell development...
  91. ncbi Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes
    Axel Thiefes
    Institute of Pharmacology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Biol Chem 280:27728-41. 2005
    ..was also suppressed in cells that expressed TAK1 antisense RNA or that were genetically deficient in JNK1/2 or p65 NFkappaB...
  92. doi 1,5-Anhydro-D-fructose attenuates lipopolysaccharide-induced cytokine release via suppression of NF-kappaB p65 phosphorylation
    Xiaojie Meng
    Department of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Science, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Biochem Biophys Res Commun 380:343-8. 2009
    ..attenuated cytokine release, and 1,5-AF directly inhibited the nuclear translocalization of the NF-kappaB p65 subunit in LPS-stimulated murine macrophage-like RAW264.7 cells...
  93. ncbi The NF-kappaB/Rel family of transcription factors in oncogenic transformation and apoptosis
    R de Martin
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Vienna International Research Cooperation Center VIRCC, Brunnerstr 59, A 1235, Vienna, Austria
    Mutat Res 437:231-43. 1999
    ..Thus, NF-kappaB has emerged also as an attractive target for therapeutic interference in a variety of pathological situations, including chronic inflammatory and autoimmune diseases, HIV infection and cancer...
  94. pmc Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice
    Hong Min Ni
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 284:4373-82. 2009
    ..However, JNK, but not Bid, was able to contribute to the TNFalpha-induced liver apoptosis in RelA-deficient embryos...
  95. ncbi p75-mediated NF-kappaB activation enhances the survival response of developing sensory neurons to nerve growth factor
    M Hamanoue
    School of Biomedical Sciences, University of St Andrews, Biomedical Science Building, St Andrews, KY16 9AJ, Scotland
    Mol Cell Neurosci 14:28-40. 1999
    ..Overexpression of either the p65 or the p50 NF-kappaB subunits resulted in NF-kappaB activation and promoted in vitro survival as effectively as NGF...
  96. doi Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction
    Konrad A Bode
    Department of Medical Microbiology and Hygiene, University of Heidelberg, Heidelberg, Germany
    J Immunol 182:2176-84. 2009
    ..LPS induced a rapid but short-lived activation of RelA, whereas CpG-DNA stimulation resulted in prolonged RelA activity at the IL-12p40 promoter...
  97. pmc NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition
    M Hinz
    Molekulare Zellbiologie, Humboldt Universitat zu Berlin, Max Delbrück Haus, 13122 Berlin, Germany
    Mol Cell Biol 19:2690-8. 1999
    ..Thus, NF-kappaB contributes to cell cycle progression, and one of its targets might be cyclin D1...
  98. ncbi Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing
    P Deloukas
    Biotechnology Section, F Hoffmann La Roche Ltd, Basel, Switzerland
    Hum Mol Genet 2:1895-900. 1993
    ..The most abundant form of NF-kappa B is the p50/p65 heterodimer...
  99. pmc Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis
    Daniela S Bassères
    Lineberger Comprehensive Cancer Center and Department of Biology, University of North Carolina, Chapel Hill, North Carolina, USA
    Cancer Res 70:3537-46. 2010
    ..where activation of oncogenic K-Ras in lung cells was coupled with inactivation of the NF-kappaB subunit p65/RelA. In this model, deletion of p65/RelA reduces the number of K-Ras-induced lung tumors both in the presence and in ..
  100. ncbi A high-resolution genetic map of mouse chromosome 19 encompassing the muscle-deficient osteochondrodystrophy (mdf-ocd) region
    C Poirier
    Unite de Genetique des Mammiferes, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mamm Genome 9:390-1. 1998
  101. pmc Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression
    Marcela Covic
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Zurich, Switzerland
    EMBO J 24:85-96. 2005
    ..CARM1 forms a complex with p300 and NF-kappaB in vivo and interacts directly with the NF-kappaB subunit p65 in vitro. CARM1 seems to act in a gene-specific manner mainly by enhancing NF-kappaB recruitment to cognate sites...

Research Grants11

  1. CD80 binding peptides as therapeutic agents in arthritis
    Mythily Srinivasan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  2. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  3. HUS Pathogenesis & clinical Outcome in an in vivo model
    James Fox; Fiscal Year: 2008
    ..We will use this model to study the pathogenesis of HUS and importantly to develop therapeutic regimens to prevent and treat EHEC disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  4. Complement Activation and Renal Ischemia/Reperfusion Injury
    JOSHUA THURMAN; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  5. Mechanisms for Hormone-Dependent NF-kB Activation
    Allan Brasier; Fiscal Year: 2007
    ..These studies will identify new therapeutic targets that can disrupt the vicious cycle of inflammation and atherosclerosis. ..
  6. REGULATION OF CYTOKINE GENES IN MUCOSAL VIRAL INFECTION
    Allan Brasier; Fiscal Year: 2006
    ..Expression of dominant-negative NF-KB and CBP/p300 coactivators will be used to determine their effect on coactivator recruitment. These studies will identify signaling mechanisms and protein interactions in viral-induced inflammation. ..
  7. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  8. Microecology-murine gut-initiation & progression of IBD
    James Fox; Fiscal Year: 2005
    ..prior and subsequent to oral vaccination with Helicobacter spp. antigens and mucosal adjuvants, elucidate how these vaccine strategies influence microflora dynamics and impact gut cytokine responses. ..
  9. Helicobacter induced hepatitis and tumorigenesis
    James Fox; Fiscal Year: 2009
    ..A more complete understanding of the etiopathogenesis of hepatobiliary disease and hepatocellular carcinoma is likely to result in new strategies for treatment and prevention of these important human diseases. ..
  10. Complement and Ischemic Acute Renal Failure
    JOSHUA THURMAN; Fiscal Year: 2007
    ..The purpose of these studies is to ameliorate ischemic ARF by blocking these pathogenic events, and to develop strategies for decreasing the morbidity and mortality associated with ischemic ARF in humans. ..