Rbck1

Summary

Gene Symbol: Rbck1
Description: RanBP-type and C3HC4-type zinc finger containing 1
Alias: AL033326, HOIL-1, HOIL-1L, UIP28, Ubce7ip3, ranBP-type and C3HC4-type zinc finger-containing protein 1, RING-type E3 ubiquitin transferase HOIL-1, heme-oxidized IRP2 ubiquitin ligase 1 homolog, novel zinc finger, C3HC4 type (RING finger) protein, ubcM4-interacting protein 28, ubiquitin-conjugating enzyme 7-interacting protein 3
Species: mouse

Top Publications

  1. ncbi Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex
    Munehiro Nakamura
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 351:340-7. 2006
  2. doi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
  3. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
  4. pmc Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction
    Kyung Soo Inn
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell 41:354-65. 2011
  5. doi SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nature 471:633-6. 2011
  6. pmc SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
    Fumiyo Ikeda
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor Stern Kai 7, D 60590 Frankfurt, Main, Germany
    Nature 471:637-41. 2011
  7. pmc Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex
    Yusuke Sato
    Structural Biology Laboratory, Life Science Division, Synchrotron Radiation Research Organization and Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 108:20520-5. 2011
  8. pmc Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection
    Satoshi Shimizu
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
    Mol Cell Biol 36:1569-83. 2016
  9. pmc The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling
    Theo Klein
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Nat Commun 6:8777. 2015
  10. pmc Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection
    Donna A MacDuff
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, United States
    elife 4:. 2015

Research Grants

Scientific Experts

  • Bruce S Hostager
  • Charles R Farber
  • Kazuhiro Iwai
  • Fuminori Tokunaga
  • Hiroaki Fujita
  • Tomoko Nakagawa
  • Yasushi Saeki
  • Shin ichi Sakata
  • Satoshi Shimizu
  • Theo Klein
  • Donna A MacDuff
  • Yoshiteru Sasaki
  • Markus A Queisser
  • Mary A Rodgers
  • Tsuyoshi Takiuchi
  • Nieves Peltzer
  • Mude Shi
  • Jae U Jung
  • Eva Rieser
  • Henning Walczak
  • John Silke
  • Kyung Soo Inn
  • Yusuke Sato
  • Fumiyo Ikeda
  • N Vanlangenakker
  • G Martinez-Noel
  • Keiji Tanaka
  • Kathrin Landgraf
  • Tobias L Haas
  • Yukari Zenke-Kawasaki
  • Munehiro Nakamura
  • Kazuhiko Fukuda
  • Tatsuaki Tsuruyama
  • Stuart E Turvey
  • Emmanuel Laplantine
  • Tiffany A Reese
  • Sohyeong Kang
  • Brian T Edelson
  • Michael R Gold
  • Christina Song
  • Antoine Dufour
  • Madison Bolger-Munro
  • John J Priatel
  • Alain Israel
  • Leslie A Weiss
  • Xin Zhang
  • Michael A Blank
  • Javier A Carrero
  • Marco Colonna
  • L David Sibley
  • Samu Melkko
  • Rosa I Viner
  • Shan Yu Fung
  • Jean Laurent Casanova
  • Jacqueline M Kimmey
  • Christina L Stallings
  • Joshua M Scurll
  • Patrick Schweigler
  • Herbert W Virgin
  • Florian Renner
  • Capucine Picard
  • Bertrand Boisson
  • Christopher M Overall
  • Catherine H Regnier
  • Amal Kambal
  • Erning Duan
  • Guofei Zhou
  • Rina Amatya
  • Alexander H Stegh
  • Yutaka Shimizu
  • Aaron Ciechanover
  • Juan Pedro Martinez-Barbera
  • Lucia Taraborrelli
  • Navdeep S Chandel
  • James W Bowman
  • Hiroyuki Takeda
  • Malcolm M Decamp
  • Antonella Montinaro
  • Barbara Pernaute
  • Peter Dráber
  • Fotini M Kouri
  • Thomas J Kelly
  • Qiming Liang
  • Hironari Tamiya
  • Tristan A Rodriguez
  • Alexander Buchberger
  • Jing Liu
  • Tatsuya Sawasaki
  • Lawrence M Knab
  • Nicole Orazio

Detail Information

Publications21

  1. ncbi Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex
    Munehiro Nakamura
    Department of Molecular Cell Biology, Graduate School of Medicine, Osaka City University, Osaka 545 8585, Japan
    Biochem Biophys Res Commun 351:340-7. 2006
    ..These results indicate that LUBAC is an E3 for activated conventional PKC, and that PKC and LUBAC regulate each other for proper PKC signaling...
  2. doi Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine and Cell Biology and Metabolism Group, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Cell Biol 11:123-32. 2009
    ..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO...
  3. doi Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction
    Tobias L Haas
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Mol Cell 36:831-44. 2009
    ..Finally, we demonstrate that sustained stability of the TNF-RSC requires LUBAC's enzymatic activity, thereby adding a third form of ubiquitin linkage to the triggering of TNF signaling by the TNF-RSC...
  4. pmc Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction
    Kyung Soo Inn
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell 41:354-65. 2011
    ....
  5. doi SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
    Fuminori Tokunaga
    Department of Biophysics and Biochemistry, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    Nature 471:633-6. 2011
    ..SHARPIN shows significant similarity to HOIL-1L (also known as RBCK1), a component of linear ubiquitin chain assembly complex (LUBAC), which induces NF-κB activation through ..
  6. pmc SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
    Fumiyo Ikeda
    Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University School of Medicine, Theodor Stern Kai 7, D 60590 Frankfurt, Main, Germany
    Nature 471:637-41. 2011
    ..This effect is further enhanced upon concurrent downregulation of HOIL-1L (also known as RBCK1), another HOIP-binding component of LUBAC...
  7. pmc Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex
    Yusuke Sato
    Structural Biology Laboratory, Life Science Division, Synchrotron Radiation Research Organization and Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 108:20520-5. 2011
    ..The NZF tail binds the proximal ubiquitin to enhance the binding affinity. These recognition mechanisms were supported by the accompanying in vitro and in vivo structure-based mutagenesis experiments...
  8. pmc Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection
    Satoshi Shimizu
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
    Mol Cell Biol 36:1569-83. 2016
    ..Thus, selective recognition of ubiquitin chains by NZFs in LUBAC underlies the regulation of LUBAC function. ..
  9. pmc The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling
    Theo Klein
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Nat Commun 6:8777. 2015
    ....
  10. pmc Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection
    Donna A MacDuff
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, United States
    elife 4:. 2015
    ..Patients with mutations in HOIL1 (RBCK1) present with amylopectinosis-associated myopathy with or without hyper-inflammation and immunodeficiency...
  11. doi HOIP deficiency causes embryonic lethality by aberrant TNFR1-mediated endothelial cell death
    Nieves Peltzer
    Centre for Cell Death, Cancer, and Inflammation CCCI, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK
    Cell Rep 9:153-65. 2014
    ..Hence, LUBAC and its linear-ubiquitin-forming activity are required for maintaining vascular integrity during embryogenesis by preventing TNFR1-mediated endothelial cell death. ..
  12. pmc HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth
    Markus A Queisser
    1 Division of Pulmonary and Critical Care Medicine
    Am J Respir Crit Care Med 190:688-98. 2014
    ..Deletion of PKCζ in experimental cancer models has been shown to increase tumor growth. However, the mechanisms of PKCζ down-regulation in cancerous cells have not been previously described...
  13. pmc The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation
    Mary A Rodgers
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
    J Exp Med 211:1333-47. 2014
    ....
  14. doi Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN
    Tsuyoshi Takiuchi
    Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8501, Japan Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565 0871, Japan
    Genes Cells 19:254-72. 2014
    ..Our observations provide molecular insights into the roles of ligase-deubiquitinase interactions in regulating molecular events resulting from linear ubiquitin conjugation. ..
  15. pmc TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members
    N Vanlangenakker
    Department for Molecular Biomedical Research, VIB, Zwijnaarde Ghent, Belgium
    Cell Death Dis 2:e230. 2011
    ..Finally, we also report RIP1-independent but RIP3-mediated necroptosis in the context of TNF signaling in particular conditions...
  16. ncbi Identification of molecular determinants required for interaction of ubiquitin-conjugating enzymes and RING finger proteins
    G Martinez-Noel
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Hamburg, Germany
    Eur J Biochem 268:5912-9. 2001
    ..The result that single amino-acid changes can regulate binding of E2 enzymes to different RING finger proteins suggests a novel approach to experimentally manipulate proteolytic pathways mediated by RING finger proteins...
  17. pmc Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development
    Kathrin Landgraf
    Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    Mol Cell Biol 30:5764-75. 2010
    ..Here we report the identification of the related proteins Sipl1 (Shank-interacting protein-like 1) and Rbck1 (RBCC protein interacting with PKC1) as novel interaction partners of Eya1...
  18. pmc HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex
    Bruce S Hostager
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 5:e11380. 2010
    ....
  19. pmc Heme induces ubiquitination and degradation of the transcription factor Bach1
    Yukari Zenke-Kawasaki
    Department of Biochemistry, Tohoku University School of Medicine, Seiryo machi 2 1, Sendai, Japan
    Mol Cell Biol 27:6962-71. 2007
    ..These results suggest that heme within a cell regulates the polyubiquitination and degradation of Bach1...
  20. ncbi A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4
    G Martinez-Noel
    Heinrich Pette Institut fur experimentelle Virologie und Immunologie an der Universitat Hamburg, Germany
    FEBS Lett 454:257-61. 1999
    ....
  21. pmc Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains
    Charles R Farber
    Department of Animal Science, University of California Davis, One Shields Ave, Davis, CA 95016 8521, USA
    BMC Genomics 7:102. 2006
    ..To confirm and further characterize each QTL, two panels of speed congenic strains were developed by introgressing CAST/EiJ (CAST) QTL alleles onto either mutant C57Bl/6J-hg/hg (HG) or wild type C57Bl/6J (B6) genetic backgrounds...

Research Grants2

  1. Using gene targeting to address the role of LRRK2 in Parkinson's disease
    Bruce Hostager; Fiscal Year: 2007
    ..This knowledge will aid in the identification of the environmental triggers and additional genetic factors that participate in the development of Parkinson's disease. ..
  2. CHARACTERIZATION OF A MAJOR OBESITY LOCUS
    Charles Farber; Fiscal Year: 2008
    ..Lastly, aim 3 uses a genetical genomics approach to map eQTL for genes within the congenic interval. Data from these aims will enhance our understanding of the genetics and physiology of obesity. ..