- Rap2B promotes proliferation, migration, and invasion of human breast cancer through calcium-related ERK1/2 signaling pathwayJiehui Di
1 Cancer Institute, Xuzhou Medical College, Xuzhou 221002, Jiangsu, P R China 2 Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC 27514, USA
Sci Rep 5:12363. 2015b>Rap2B, a member of GTP-binding proteins, is widely upregulated in many types of tumors and promotes migration and invasion of human suprarenal epithelioma. However, the function of Rap2B in breast cancer is unknown...
- Crystal structure of the RUN domain of the RAP2-interacting protein xMutsuko Kukimoto-Niino
RIKEN Genomic Sciences Center, Yokohama 230 0045, Japan
J Biol Chem 281:31843-53. 2006..This fragment, the RPIPx RUN domain, interacted specifically with Rap2B in vitro in a nucleotide-dependent manner. The crystal structure of the RPIPx RUN domain was determined at 2...
- Rap2 function requires palmitoylation and recycling endosome localizationYukiko Uechi
Division of Cell Biology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
Biochem Biophys Res Commun 378:732-7. 2009Rap2A, Rap2B, and Rap2C are Ras-like small G proteins. The role of their post-translational processing has not been investigated due to the lack of information on their downstream signaling...