Rala

Summary

Gene Symbol: Rala
Description: v-ral simian leukemia viral oncogene A (ras related)
Alias: 3010001O15Rik, AW322615, Ral, Rasl1, ras-related protein Ral-A, RAS-like, family 1, ral-A protein, v-ral simian leukemia viral oncogene homolog A (ras related)
Species: mouse

Top Publications

  1. doi The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells
    Jamie A Lopez
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Biol Chem 283:17939-45. 2008
  2. ncbi Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c
    Xiao Wei Chen
    Department of Molecular and Integrative Physiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Dev Cell 13:391-404. 2007
  3. pmc Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases
    Leanna R Gentry
    From the Departments of Pharmacology and
    J Biol Chem 290:22851-61. 2015
  4. doi Role for RalA downstream of Rac1 in skeletal muscle insulin signalling
    Nobuyuki Takenaka
    Laboratory of Cell Biology, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, 1 1 Gakuen cho, Naka ku, Sakai 599 8531, Japan
    Biochem J 469:445-54. 2015
  5. pmc RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development
    Amlan Das
    University of Pennsylvania Department of Biology, Philadelphia, PA 19104, USA
    J Cell Sci 127:686-99. 2014
  6. pmc A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
    Xiao Wei Chen
    Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Mol Biol Cell 22:141-52. 2011
  7. pmc Elevated RalA activity in the hippocampus of PI3Kγ knock-out mice lacking NMDAR-dependent long-term depression
    Su Eon Sim
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    BMB Rep 46:103-6. 2013
  8. doi Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis
    Pascal Peschard
    Oncogene Team, Division of Cancer Biology, Institute of Cancer Research, London SW3 6JB, UK
    Curr Biol 22:2063-8. 2012
  9. pmc Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation
    Yasuhito Shirai
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Mol Biol Cell 22:1340-52. 2011
  10. doi M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex
    Koji Hase
    Laboratory for Epithelial Immunobiology, Kanagawa 230 0045, Japan
    Nat Cell Biol 11:1427-32. 2009

Scientific Experts

  • Yasuhito Shirai
  • Zhiyong Zhao
  • Nagaraj Balasubramanian
  • Xiao Wei Chen
  • Pascal Peschard
  • Nobuyuki Takenaka
  • Leanna R Gentry
  • Amlan Das
  • Christopher J Marshall
  • Su Eon Sim
  • Matthias Corrotte
  • Christina D Nichols
  • Nicolas Vitale
  • Dara Leto
  • Koji Hase
  • Alan R Saltiel
  • Vidya Bodempudi
  • Sanda Ljubicic
  • Jamie A Lopez
  • Akiyuki Takaya
  • Jacques T Weissman
  • Jing Zhang
  • Lizhong Xu
  • Tetsuya Hosooka
  • Adrienne D Cox
  • Akiyuki Nishimura
  • Timothy C Elston
  • Tetsuya Noguchi
  • Channing J Der
  • Timothy D Martin
  • Junko Fujita
  • Atsu Aiba
  • Motohiro Nishida
  • Denis Tsygankov
  • Yukio Sumi
  • Keiko Matsuda
  • Takaya Satoh
  • Wei Guo
  • Madeleine J Oudin
  • Katarzyna Falenta
  • Giovanna Lalli
  • Bin Wu
  • Shanshan Feng
  • Patrick Doherty
  • Sangeetha Gajendra
  • Eunjoon Kim
  • Hye ryeon Lee
  • Kyungmin Lee
  • Joseph Bakes
  • Sun Lim Choi
  • Bong Kiun Kaang
  • Kihoon Han
  • Jae Ick Kim
  • Deok Jin Jang
  • Valérie Leblanc-Dominguez
  • Sabrina Guichard
  • Afshan McCarthy
  • Gordon Stamp
  • Maggie Yeo
  • STUART DECKER
  • Genggeng Yu
  • Alan Cheng
  • Tingting Xiong
  • Marie Line Harlay
  • J W Hudson
  • Nancy J Grant
  • Marie France Bader
  • An Phu Tran Nyguyen
  • James E Casanova
  • Tuba Esfandyari
  • George H De Vries
  • Stacey L Thomas
  • Mark Piedra
  • Charles Yeaman
  • Dusica Babovick-Vuksanovic
  • D Wade Clapp
  • Hiroshi Kitamura
  • Hiroshi Ohno
  • Richard A Woo
  • C Clayton Hazelett
  • Masumi Ohmae
  • Masatoshi Ito
  • Victor F Mautner
  • Luis F Parada
  • Farnaz Yamoutpoor
  • Lan Kluwe
  • Romano Regazzi
  • Arkadiusz Z Dudek
  • Hiroshi Watarai
  • Shunsuke Kimura

Detail Information

Publications28

  1. doi The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells
    Jamie A Lopez
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, NSW, Australia
    J Biol Chem 283:17939-45. 2008
    b>RalA is a small GTPase that is thought to facilitate exocytosis through its direct interaction with the mammalian exocyst complex...
  2. ncbi Activation of RalA is required for insulin-stimulated Glut4 trafficking to the plasma membrane via the exocyst and the motor protein Myo1c
    Xiao Wei Chen
    Department of Molecular and Integrative Physiology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Dev Cell 13:391-404. 2007
    ..Here we report that insulin regulates this process via the G protein RalA, which is present in Glut4 vesicles and interacts with the exocyst in adipocytes...
  3. pmc Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases
    Leanna R Gentry
    From the Departments of Pharmacology and
    J Biol Chem 290:22851-61. 2015
    The Ras-like small GTPases RalA and RalB are well validated effectors of RAS oncogene-driven human cancer growth, and pharmacologic inhibitors of Ral function may provide an effective anti-Ras therapeutic strategy...
  4. doi Role for RalA downstream of Rac1 in skeletal muscle insulin signalling
    Nobuyuki Takenaka
    Laboratory of Cell Biology, Department of Biological Science, Graduate School of Science, Osaka Prefecture University, 1 1 Gakuen cho, Naka ku, Sakai 599 8531, Japan
    Biochem J 469:445-54. 2015
    ..In the present study, we examined the role of the small GTPase RalA downstream of Rac1 in skeletal muscle fibres isolated from genetically modified mice...
  5. pmc RalA promotes a direct exocyst-Par6 interaction to regulate polarity in neuronal development
    Amlan Das
    University of Pennsylvania Department of Biology, Philadelphia, PA 19104, USA
    J Cell Sci 127:686-99. 2014
    ..in vivo postnatal electroporation and conditional genetic ablation, we show that the Ras-like small GTPase RalA and its effector, the exocyst, regulate the morphology and polarized migration of neural progenitors derived from ..
  6. pmc A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action
    Xiao Wei Chen
    Life Sciences Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Mol Biol Cell 22:141-52. 2011
    ..We previously reported that activation of the small GTPase RalA downstream of PI 3-kinase plays a critical role in this process by mobilizing the exocyst complex for GLUT4 vesicle ..
  7. pmc Elevated RalA activity in the hippocampus of PI3Kγ knock-out mice lacking NMDAR-dependent long-term depression
    Su Eon Sim
    Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    BMB Rep 46:103-6. 2013
    ..The activity of RalA, a small GTP-binding protein, increases following NMDAR-LTD inducing stimuli, and this increase in RalA activity is ..
  8. doi Genetic deletion of RALA and RALB small GTPases reveals redundant functions in development and tumorigenesis
    Pascal Peschard
    Oncogene Team, Division of Cancer Biology, Institute of Cancer Research, London SW3 6JB, UK
    Curr Biol 22:2063-8. 2012
    RAL small GTPases, encoded by the Rala and Ralb genes, are members of the RAS superfamily of small GTPases and can act as downstream effectors of RAS [1]...
  9. pmc Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation
    Yasuhito Shirai
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Mol Biol Cell 22:1340-52. 2011
    ..In addition, we identify the small G protein RalA as a binding partner of PKCη, which binds to the C1 domain, an indispensable region for the morphological change...
  10. doi M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex
    Koji Hase
    Laboratory for Epithelial Immunobiology, Kanagawa 230 0045, Japan
    Nat Cell Biol 11:1427-32. 2009
    ..Furthermore, blockage of the interaction of M-Sec with Ral and the exocyst complex, which serves as a downstream effector of Ral, attenuated the formation of membrane ..
  11. ncbi Nidogen/entactin (Nid) maps to the proximal end of mouse chromosome 13 linked to beige (bg) and identifies a new region of homology between mouse and human chromosomes
    N A Jenkins
    ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702
    Genomics 9:401-3. 1991
  12. ncbi A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci
    M J Justice
    Mammalian Genetics Laboratory, BRI Basic Research Program, NCI Frederick Cancer Research Facility, Maryland 21701
    Genomics 6:341-51. 1990
    ..The map locations of Ctla-3, Dhfr, Fim-1, 4/12, Hexb, Hilda, Inhba, Lamb-1.13, Ral, Rrm2-ps3, and Tcrg were determined with respect to the beige (bg) and satin (sa) loci...
  13. ncbi A putative effector of Ral has homology to Rho/Rac GTPase activating proteins
    S H Park
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA
    Oncogene 11:2349-55. 1995
    We report here the cloning of a gene encoding a novel Ral interacting protein (RIP1) from a cDNA expression library using radiolabeled Ral as probe. RIP1 binds to Ral in a GTP-dependent manner. The 4...
  14. doi Ral isoforms are implicated in Fc gamma R-mediated phagocytosis: activation of phospholipase D by RalA
    Matthias Corrotte
    Département Neurotransmission et Sécrétion Neuroendocrine, Institut des Neurosciences Cellulaires et Integratives, Centre National de la Recherche Scientifique, Unité Propre de Recherche 3212, Strasbourg, France
    J Immunol 185:2942-50. 2010
    ..In this study, we investigated the role of a potential PLD regulator, the Ral GTPases RalA and RalB, in murine RAW 264.7 macrophages...
  15. pmc Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex
    Christina D Nichols
    Department of Microbiology, University of Virginia Health System, Charlottesville, VA 22908 0732, USA
    Curr Biol 20:1316-20. 2010
    ..Exocyst assembly requires activation of the small GTPase RalA, which we show is triggered during Salmonella infection by the translocated effector, SopE...
  16. pmc RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling
    Nagaraj Balasubramanian
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Curr Biol 20:75-9. 2010
    ..The small GTPase RalA is activated in metastatic cancers through multiple mechanisms and specifically induces anchorage independence...
  17. ncbi A new role of ran GTPase
    T Nishimoto
    Graduate School of Medical Science, Kyushu University, Fukuoka, 812 8582, Japan
    Biochem Biophys Res Commun 262:571-4. 1999
    ..In both microtubule assembly and nucleocytoplasmic transport, chromosomal localization of RCC1 is important to carry out the functions of RanGTPase. In this regard, a future intriguing question is how RCC1 interacts with chromatin DNA...
  18. pmc The GTPase RalA regulates different steps of the secretory process in pancreatic beta-cells
    Sanda Ljubicic
    Department of Cell Biology and Morphology, University of Lausanne, Lausanne, Switzerland
    PLoS ONE 4:e7770. 2009
    b>RalA and RalB are multifuntional GTPases involved in a variety of cellular processes including proliferation, oncogenic transformation and membrane trafficking...
  19. pmc Ral overactivation in malignant peripheral nerve sheath tumors
    Vidya Bodempudi
    Department of Medicine, KUMC Molecular Medicine Laboratory, University of Kansas School of Medicine, 1000 Hixon, Mail Stop 4037, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Mol Cell Biol 29:3964-74. 2009
    ..b>RalA, however, was overactivated in all MPNST cells and tumor samples compared to nontransformed Schwann cells...
  20. ncbi The physical and genetic map surrounding the Lyst gene on mouse chromosome 13
    D J Misumi
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Genomics 40:147-50. 1997
    ..These data are consistent with LYST being the gene for the human Chediak-Higashi Syndrome and strengthen the synteny relationship between MMU13 and human 1q43...
  21. pmc R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes
    Akiyuki Takaya
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Osaka 565 0871, Japan
    Mol Biol Cell 18:1850-60. 2007
    ..correlated with the accumulation of an R-Ras effector, the Rgl2/Rlf guanine nucleotide exchange factor for RalA, and also with high RalA activity...
  22. ncbi Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors
    Jing Zhang
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Blood 104:1679-87. 2004
    ..H-ras: Raf/ERK (extracellular signal-regulated kinase), phosphatidyl inositol 3 (PI3)-kinase/Akt, and RalGEF/RalA. However, only constitutive activation of the MEK (MAPK [mitogen-activated protein kinase]/ERK kinase)/ERK pathway ..
  23. ncbi G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway
    Jacques T Weissman
    ACADIA Pharmaceuticals Inc, 3911 Sorrento Valley Blvd, San Diego, CA 92121, USA
    Oncogene 23:241-9. 2004
    ..A constitutively active mutant of Galphai2 also mediated Ras/rap-dependent responses. These data indicate that GPCRs coupled to pertussis-toxin-sensitive G-proteins activate Rap through a Galpha subunit, C3G, and Src-dependent pathway...
  24. pmc Elevated phospholipase D activity in H-Ras- but not K-Ras-transformed cells by the synergistic action of RalA and ARF6
    Lizhong Xu
    Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
    Mol Cell Biol 23:645-54. 2003
    ..PLD activity in H-Ras-transformed cells is dependent upon RalA, and consistent with a lack of elevated PLD activity in K-Ras-transformed cells, RalA was not activated in K-Ras-..
  25. ncbi Tissue-specific expression of GTPas RalA and RalB during embryogenesis and regulation by epithelial-mesenchymal interaction
    Z Zhao
    Yale Child Health Research Center, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Mech Dev 97:201-4. 2000
    b>RalA and RalB are members of the Ras-like GTP-binding protein family. To investigate if Ral GTPases play a role in development, temporal and spatial patterns of RalA and RalB gene expression were examined during embryogenesis...
  26. ncbi Sak kinase gene structure and transcriptional regulation
    J W Hudson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Canada
    Gene 241:65-73. 2000
    ..Using various Sak promoter/luciferase constructs, the core promoter region required for expression was located within 400bp of the message Cap site, and sequence further 5' strongly suppressed transcription...
  27. ncbi Comparative mapping in the beige-satin region of mouse chromosome 13
    C M Perou
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, 84132, USA
    Genomics 39:136-46. 1997
    ..The results show that the bg region of mouse Chr 13 is highly conserved on human Chr 1q42-q44 and provide a starting point for a complete functional analysis of the entire bg-sa interval...
  28. ncbi Ras-like genes and gene families in the mouse
    G Drivas
    Department of Biochemistry, New York University Medical Center, New York 10016
    Mamm Genome 1:112-7. 1991
    ..Two possible clusters of Ras-like and/or G protein genes were identified, on Chrs 9 and 17...