Raet1c

Summary

Gene Symbol: Raet1c
Description: retinoic acid early transcript gamma
Alias: RAE-1gamma, retinoic acid early-inducible protein 1-gamma, RAE-1-gamma
Species: mouse

Top Publications

  1. ncbi Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: a novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules
    Z Zou
    Department of Medical Genetics, Osaka University
    J Biochem 119:319-28. 1996
  2. ncbi Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain
    M Nomura
    Department of Medical Genetics, Osaka University
    J Biochem 120:987-95. 1996
  3. ncbi Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco 94143, USA
    Immunity 12:721-7. 2000
  4. ncbi Regulation of cutaneous malignancy by gammadelta T cells
    M Girardi
    Department of Dermatology and Yale Skin Diseases Research Core Center, King s College, London SE1 9RT, UK
    Science 294:605-9. 2001
  5. pmc NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules
    Melissa Lodoen
    Department of Microbiology and Immunology, Box 0414, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 197:1245-53. 2003
  6. ncbi Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor
    Jessica A Hamerman
    Department of Microbiology and Immunology, and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 172:2001-5. 2004
  7. pmc Murine NKG2D ligands: "double, double toil and trouble"
    Asanga Samarakoon
    Laboratory of Molecular Immunology, Blood Research Institute, Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Mol Immunol 46:1011-9. 2009
  8. pmc Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus
    Jurica Arapovic
    Department of Histology and Embryology, University of Rijeka, Croatia
    J Virol 83:8198-207. 2009
  9. pmc Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms
    Li Zhi
    Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Biochemistry 49:2443-53. 2010
  10. pmc The NKG2D ligands RAE-1δ and RAE-1ε differ with respect to their receptor affinity, expression profiles and transcriptional regulation
    Oriane Cedile
    CRN2M, CNRS UMR 6231, Universite de la Mediterranee, Universite Paul Cezanne, Faculte de Medecine, Marseille, France
    PLoS ONE 5:e13466. 2010

Detail Information

Publications11

  1. ncbi Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: a novel cDNA family encodes cell surface proteins sharing partial homology with MHC class I molecules
    Z Zou
    Department of Medical Genetics, Osaka University
    J Biochem 119:319-28. 1996
    ..As the overall nucleotide sequence homology among these three cDNAs was about 98%, they constitute a novel gene family which is likely to be involved in early mammalian embryogenesis...
  2. ncbi Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain
    M Nomura
    Department of Medical Genetics, Osaka University
    J Biochem 120:987-95. 1996
    ....
  3. ncbi Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice
    A Cerwenka
    Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco 94143, USA
    Immunity 12:721-7. 2000
    ..These studies identify a family of ligands for the activating NKG2D receptor on NK and T cells, which may play an important role in innate and adaptive immunity...
  4. ncbi Regulation of cutaneous malignancy by gammadelta T cells
    M Girardi
    Department of Dermatology and Yale Skin Diseases Research Core Center, King s College, London SE1 9RT, UK
    Science 294:605-9. 2001
    ..Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy...
  5. pmc NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules
    Melissa Lodoen
    Department of Microbiology and Immunology, Box 0414, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 197:1245-53. 2003
    ..These experiments demonstrate that gp40 impairs NK cell recognition of virus-infected cells through disrupting the RAE-1-NKG2D interaction...
  6. ncbi Cutting edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor
    Jessica A Hamerman
    Department of Microbiology and Immunology, and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 172:2001-5. 2004
    ..RAE-1-NKG2D interactions provide a mechanism by which NK cells and infected macrophages communicate directly during an innate immune response to infection...
  7. pmc Murine NKG2D ligands: "double, double toil and trouble"
    Asanga Samarakoon
    Laboratory of Molecular Immunology, Blood Research Institute, Division of Neoplastic Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, United States
    Mol Immunol 46:1011-9. 2009
    ..communication between NKG2D receptor and its ligands travel through a two way road? If so, what do the 'target' cells get in turn, only death? How efficient are these ligands as molecular targets for NK cell-mediated tumor immunotherapy?..
  8. pmc Differential susceptibility of RAE-1 isoforms to mouse cytomegalovirus
    Jurica Arapovic
    Department of Histology and Embryology, University of Rijeka, Croatia
    J Virol 83:8198-207. 2009
    ..This difference can be attributed to the absence of a PLWY motif from RAE-1delta. Altogether, these findings provide evidence for a novel mechanism of host escape from viral immunoevasion of NKG2D-dependent control...
  9. pmc Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms
    Li Zhi
    Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 1892, USA
    Biochemistry 49:2443-53. 2010
    ..Molecular modeling of the different RAE-1 isoforms suggests a potential site for the m152 interaction...
  10. pmc The NKG2D ligands RAE-1δ and RAE-1ε differ with respect to their receptor affinity, expression profiles and transcriptional regulation
    Oriane Cedile
    CRN2M, CNRS UMR 6231, Universite de la Mediterranee, Universite Paul Cezanne, Faculte de Medecine, Marseille, France
    PLoS ONE 5:e13466. 2010
    ..The goals of this study are first to characterize the in vivo and in vitro expression of each gene and secondly to elucidate the mechanisms underlying their respective expression, which are far from known...
  11. pmc Superior induction and maintenance of protective CD8 T cells in mice infected with mouse cytomegalovirus vector expressing RAE-1γ
    Tihana Trsan
    Department of Histology and Embryology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia
    Proc Natl Acad Sci U S A 110:16550-5. 2013
    ..Thus, vectors expressing RAE-1γ represent a promising approach in the development of CD8 T-cell-based vaccines. ..