pygopus 2

Summary

Gene Symbol: pygopus 2
Description: pygopus 2
Alias: 1190004M21Rik, pygopus homolog 2
Species: mouse

Top Publications

  1. ncbi pygopus 2 has a crucial, Wnt pathway-independent function in lens induction
    Ni Song
    Divisions of Pediatric Ophthalmology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 134:1873-85. 2007
  2. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
  3. ncbi Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2
    Boan Li
    Department of Biological Chemistry, University of California, Irvine, California 92697 1700, USA
    Genesis 45:318-25. 2007
  4. pmc Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation
    Bingnan Gu
    Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA
    J Cell Biol 185:811-26. 2009
  5. pmc Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component
    Baoan Li
    Department of Biological Chemistry, Developmental Biology Center, University of California, Irvine, CA 92697, USA
    Genomics 84:398-405. 2004
  6. pmc Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation
    Mahalakshmi Nair
    Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
    Dev Biol 320:446-55. 2008
  7. pmc Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice
    K Watanabe
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA
    Oncogene 33:632-42. 2014
  8. pmc Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells
    Bingnan Gu
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Cell Stem Cell 13:48-61. 2013
  9. pmc Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development
    Alla Narytnyk
    Institute of Genetic Medicine, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Stem Cell Rev 10:60-8. 2014
  10. pmc Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia
    Peng Sun
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697 and
    Proc Natl Acad Sci U S A 111:10215-20. 2014

Scientific Experts

  • Kristopher R Schwab
  • Xing Dai
  • Peng Sun
  • Claudio Cantù
  • Boan Li
  • Bingnan Gu
  • Catherine Rhéaume
  • K Watanabe
  • Alla Narytnyk
  • Kazuhide Watanabe
  • Magid Fallahi
  • Michel Aguet
  • George Hausmann
  • Tomas Valenta
  • Konrad Basler
  • Nicolas Jonckheere
  • Mahalakshmi Nair
  • Andy Teng
  • Virginia Bilanchone
  • Ni Song
  • Baoan Li
  • Valerie Horsley
  • Andreas Moor
  • X Dai
  • Di Wu
  • M Fallahi
  • Oliver Clewes
  • Maya Sieber-Blum
  • Bernard Verdon
  • Dario Zimmerli
  • Megan E Afetian
  • Briana Lee
  • Kevin Gillinder
  • Nathalie Vilain
  • Michael T Lewis
  • Ricardo C Moraes
  • Ken Ichi Takemaru
  • Aihua Li
  • Sarah Millar
  • Jacqueline M Veltmaat
  • Yuanyang Yuan
  • Eva Y H P Lee
  • Anshu Agrawal
  • Erin Mayes
  • Durga Prasad Mishra
  • Maike Sander
  • Ippei Nagamori
  • Hung Ping Shih
  • Paolo Sassone-Corsi
  • Oleg Lioubinski
  • Terry Yamaguchi
  • Richard A Lang
  • Marian L Waterman
  • Larry T Patterson
  • Xinhua Lin
  • Stefano Piccolo
  • Jesus E Munguia
  • Ming Hu
  • Steven S Potter
  • Shannon Jessen
  • Douglas R Mackay
  • Ji Ma

Detail Information

Publications13

  1. ncbi pygopus 2 has a crucial, Wnt pathway-independent function in lens induction
    Ni Song
    Divisions of Pediatric Ophthalmology, Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 134:1873-85. 2007
    ..Here we have investigated the microophthalmia that arises in mice with a germline null mutation of pygopus 2. We show that this phenotype is a consequence of defective lens development at inductive stages...
  2. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  3. ncbi Developmental phenotypes and reduced Wnt signaling in mice deficient for pygopus 2
    Boan Li
    Department of Biological Chemistry, University of California, Irvine, California 92697 1700, USA
    Genesis 45:318-25. 2007
    ..Taken together, our studies show for the first time that mpygo2 deletion affects embryonic development of some but not all Wnt-requiring tissues...
  4. pmc Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation
    Bingnan Gu
    Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, USA
    J Cell Biol 185:811-26. 2009
    ....
  5. pmc Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component
    Baoan Li
    Department of Biological Chemistry, Developmental Biology Center, University of California, Irvine, CA 92697, USA
    Genomics 84:398-405. 2004
    ....
  6. pmc Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation
    Mahalakshmi Nair
    Department of Biological Chemistry, University of California, Irvine, CA 92697, USA
    Dev Biol 320:446-55. 2008
    ..b>Pygopus 2 (Pygo2) belongs to a family of evolutionarily conserved PHD finger proteins thought to act as co-activators of ..
  7. pmc Chromatin effector Pygo2 regulates mammary tumor initiation and heterogeneity in MMTV-Wnt1 mice
    K Watanabe
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA
    Oncogene 33:632-42. 2014
    ..We have previously shown that Pygopus 2 (Pygo2), a chromatin effector and context-dependent Wnt signaling coactivator, regulates mammary gland ..
  8. pmc Chromatin effector Pygo2 mediates Wnt-notch crosstalk to suppress luminal/alveolar potential of mammary stem and basal cells
    Bingnan Gu
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Cell Stem Cell 13:48-61. 2013
    Epigenetic mechanisms regulating lineage differentiation of mammary stem cells (MaSCs) remain poorly understood. Pygopus 2 (Pygo2) is a histone methylation reader and a context-dependent Wnt/β-catenin coactivator...
  9. pmc Neural crest stem cell-specific deletion of the Pygopus2 gene modulates hair follicle development
    Alla Narytnyk
    Institute of Genetic Medicine, Newcastle University, Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Stem Cell Rev 10:60-8. 2014
    ..in neural crest cells, we analyzed Wnt1-cre(+/-)::Pygo2(-/-) mice in which the β-catenin co-activator gene, Pygopus 2 (Pygo2), is deleted specifically in neural crest cells...
  10. pmc Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia
    Peng Sun
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697 and
    Proc Natl Acad Sci U S A 111:10215-20. 2014
    ..Here, we show that chromatin effector Pygopus homolog 2 (Pygo2) produced by the epithelial cells facilitates depilation-induced hair regeneration, as well as β-..
  11. pmc Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development
    Claudio Cantù
    Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland
    Genes Dev 28:1879-84. 2014
    ..Furthermore, we uncover a new regulatory circuit in which Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription. ..
  12. doi The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription
    Claudio Cantù
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Development 140:2377-86. 2013
    ....
  13. pmc Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation
    Nicolas Jonckheere
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 318:224-35. 2008
    ..Together, our data suggest a previously unappreciated role for mesenchymal Wnt signaling in regulating pancreatic organ growth and cell differentiation...