Pvrl1

Summary

Gene Symbol: Pvrl1
Description: poliovirus receptor-related 1
Alias: AI835281, AW549174, Cd111, HIgR, HveC, PRR, PRR1, nectin-1, herpes virus entry mediator C, herpesvirus entry mediator C, nectin-1, nectin-1 alpha, nectin-1 delta, poliovirus receptor-related protein 1
Species: mouse

Top Publications

  1. doi Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons
    Seung T Lim
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Comp Neurol 507:1228-44. 2008
  2. doi Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density
    Seung T Lim
    Neuroscience Department, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    J Neurochem 120:741-51. 2012
  3. pmc Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC
    Sarah M Richart
    Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
    J Virol 77:3307-11. 2003
  4. pmc Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery
    Hideru Togashi
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 174:141-51. 2006
  5. pmc Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1
    Sarah J Kopp
    Department of Microbiology Immunology, Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:17916-20. 2009
  6. pmc Herpesvirus entry mediator and nectin-1 mediate herpes simplex virus 1 infection of the murine cornea
    Andrew H Karaba
    The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Virol 85:10041-7. 2011
  7. pmc Alternative entry receptors for herpes simplex virus and their roles in disease
    Joann M Taylor
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cell Host Microbe 2:19-28. 2007
  8. ncbi Spatiotemporal changes of the herpes simplex virus entry receptor nectin-1 in murine brain during postnatal development
    Szatmar Horvath
    Department of Psychiatry, Faculty of Medicine, University of Szeged, Szeged, Hungary
    J Neurovirol 12:161-70. 2006
  9. ncbi Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development
    Maiko Inagaki
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Development 132:1525-37. 2005
  10. pmc In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa
    Melissa M Linehan
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 78:2530-6. 2004

Scientific Experts

  • Mikio Furuse
  • Emese Prandovszky
  • Toshiyuki Yoshida
  • PAUL R BRAKEMAN
  • Yoshimi Takai
  • Sarah J Kopp
  • Jun Miyoshi
  • Andrew H Karaba
  • Seung T Lim
  • Tomoyuki Honda
  • Hideru Togashi
  • Noriko Okabe
  • Kazuya Shimizu
  • Howard J Federoff
  • Koji Morimoto
  • Maiko Inagaki
  • Hisakazu Ogita
  • Miki Tanaka-Okamoto
  • Zhufeng Yang
  • Tomomi Kawakatsu
  • Conor W Sipe
  • Fumie Kureha
  • Kenji Irie
  • Salil A Lachke
  • Jocelyn M Mora
  • Navika D Shukla
  • Allison Chang
  • Michael L Robinson
  • Claude Krummenacher
  • Richard Longnecker
  • Gary H Cohen
  • Roselyn J Eisenberg
  • L Menotti
  • Ghazal Banisadr
  • Richard J Miller
  • Jinsook Kim
  • Rupalatha Maddala
  • Kumi Ozaki-Kuroda
  • Akira Mizoguchi
  • Masakazu Takeuchi
  • Hiroyuki Nakanishi
  • Rita E Giuliano
  • Kyoji Takekuni
  • Makoto Adachi
  • Masatoshi Takeichi
  • Martin J Barron
  • Kazuhiko Yoshida
  • Patricia G Spear
  • Elena Martínez-Sanz
  • Joann M Taylor
  • S Seth
  • Kotaro Wakamatsu
  • Toshiaki Sakisaka
  • Yasuhisa Sakamoto
  • Deborah L Even
  • Szatmar Horvath
  • Taihei Fukuyama
  • Hiroyoshi Ishizaki
  • Clara Martinez-Rico
  • Hao Ding
  • Melissa M Linehan
  • Morito Monden
  • Sarah M Richart
  • Wataru Ikeda
  • Tatsushi Shingai
  • Doo Yeon Kim
  • Lixia Liu
  • DENISE K MARCIANO
  • Cynthia Grimsley-Myers
  • Mitsuo Kinugasa
  • William J Muller
  • Tatsuro Ishida
  • Gerard M Beaudoin
  • Jianyi Lee
  • Louis F Reichardt
  • Yoshiki Kubo
  • Seimi Satomi-Kobayashi
  • Xiaowei Lu
  • Susan Zimmerman
  • Laura K Cohen
  • Ken ichi Hirata
  • Yoshiyuki Rikitake
  • Qiongchao Xi
  • Marianne Baithun
  • Cynthia C Morton
  • Tibor Valyi-Nagy
  • James F Gusella
  • Michael E Talkowski
  • Mark A Fenwick
  • Quynh T Duong

Detail Information

Publications47

  1. doi Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons
    Seung T Lim
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Comp Neurol 507:1228-44. 2008
    ..These data indicate that the synaptic localization of nectin-1 and l-afadin are F-actin-dependent and that the shedding of nectin-1 is a mechanism contributing to synaptic plasticity...
  2. doi Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density
    Seung T Lim
    Neuroscience Department, Georgetown University Medical Center, Washington, District of Columbia 20057, USA
    J Neurochem 120:741-51. 2012
    ..Expression of these mutants significantly alters the density of dendritic spines. These findings suggest that ectodomain shedding of nectin-1 regulates dendritic spine density and related synaptic functions...
  3. pmc Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC
    Sarah M Richart
    Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
    J Virol 77:3307-11. 2003
    ..Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons...
  4. pmc Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery
    Hideru Togashi
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 174:141-51. 2006
    ..These results suggest that the axon-biased localization of N1 and its trans-interaction with N3 in cooperation with the cadherin machinery is critical for the ordered association of axons and dendrites...
  5. pmc Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1
    Sarah J Kopp
    Department of Microbiology Immunology, Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:17916-20. 2009
    ....
  6. pmc Herpesvirus entry mediator and nectin-1 mediate herpes simplex virus 1 infection of the murine cornea
    Andrew H Karaba
    The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Virol 85:10041-7. 2011
    ..This is in contrast to what was reported for studies of HSV-2 in vagina and brain and suggests that receptor requirements for HSV vary depending on the route of inoculation and/or serotype...
  7. pmc Alternative entry receptors for herpes simplex virus and their roles in disease
    Joann M Taylor
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Cell Host Microbe 2:19-28. 2007
    Either herpesvirus entry mediator (HVEM, TNFRSF14) or nectin-1 (PVRL1) is sufficient for herpes simplex virus (HSV) infection of cultured cells. The contribution of individual receptors to infection in vivo and to disease is less clear...
  8. ncbi Spatiotemporal changes of the herpes simplex virus entry receptor nectin-1 in murine brain during postnatal development
    Szatmar Horvath
    Department of Psychiatry, Faculty of Medicine, University of Szeged, Szeged, Hungary
    J Neurovirol 12:161-70. 2006
    ..The authors also describe nectin-1-related pathways controlling neuronal cell migration/brain morphogenesis, the disruption of which might lead to the emergence of mental disorders with a rapid cognitive decline...
  9. ncbi Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development
    Maiko Inagaki
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Development 132:1525-37. 2005
    ..To further explore the function of nectins, we generated nectin 1-/- and nectin 3-/-)mice...
  10. pmc In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa
    Melissa M Linehan
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 78:2530-6. 2004
    ..Together, these results suggest the importance of nectin-1 in mediating viral entry for both HSV-1 and HSV-2 in the genital mucosa in female hosts...
  11. ncbi Separation force measurements reveal different types of modulation of E-cadherin-based adhesion by nectin-1 and -3
    Clara Martinez-Rico
    UMR 144 CNRS Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    J Biol Chem 280:4753-60. 2005
    ....
  12. pmc Striking similarity of murine nectin-1alpha to human nectin-1alpha (HveC) in sequence and activity as a glycoprotein D receptor for alphaherpesvirus entry
    D Shukla
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Virol 74:11773-81. 2000
    A cDNA encoding the murine homolog of human nectin-1alpha (also known as poliovirus receptor-related protein 1 [Prr1] and herpesvirus entry protein C [HveC]) was isolated...
  13. ncbi Involvement of nectins in the formation of puncta adherentia junctions and the mossy fiber trajectory in the mouse hippocampus
    Tomoyuki Honda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    Mol Cell Neurosci 31:315-25. 2006
    ..In addition, the abnormal mossy fiber trajectory was observed. These results indicate that nectins are involved in the formation of PAJs, which maintain the proper mossy fiber trajectory...
  14. ncbi The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1
    S Seth
    Institute of Immunology, Hannover Medical School, Carl Neuberg Str 1, 30625 Hannover, Germany
    Biochem Biophys Res Commun 364:959-65. 2007
    ..Moreover, T cell adhesion to insect cells expressing mCD155 is blocked by these antibodies depending on the T cell subtype. These results suggest a function of the CD96/CD155-adhesion system in T cell biology...
  15. pmc The cell adhesion molecule nectin-1 is critical for normal enamel formation in mice
    Martin J Barron
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Hum Mol Genet 17:3509-20. 2008
    ..Importantly, our results show that integrity of the SI-ameloblast interface is essential for normal enamel mineralization...
  16. ncbi The requirements for herpes simplex virus type 1 cell-cell spread via nectin-1 parallel those for virus entry
    Deborah L Even
    Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, 800 Rose St, UKMC MS415, Lexington, KY 40536 0298, USA
    Virus Res 119:195-207. 2006
    ..Taken together, our results indicate that nectin-1-dependent events occurring at the plasma membrane during cell-cell spread were equivalent to those for virus entry...
  17. ncbi Vav2 as a Rac-GDP/GTP exchange factor responsible for the nectin-induced, c-Src- and Cdc42-mediated activation of Rac
    Tomomi Kawakatsu
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Osaka 565 0871, Japan
    J Biol Chem 280:4940-7. 2005
    ..Cdc42 activated through c-Src then enhanced the GEF activity of tyrosine-phosphorylated Vav2 on Rac1. These results indicate that Vav2 is a GEF responsible for the nectin-induced, c-Src-, and Cdc42-mediated activation of Rac...
  18. ncbi Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities
    K Satoh-Horikawa
    Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, c o JCR Pharmaceuticals Co, Ltd, 2 2 10 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Biol Chem 275:10291-9. 2000
    ..These results indicate that the nectin family consists of at least three members, nectin-1, -2, and -3, all of which show homophilic and heterophilic cell-cell adhesion activities and are localized at cadherin-based AJs...
  19. ncbi Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo
    Noriko Okabe
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka, Japan
    Dev Dyn 230:174-86. 2004
    ..These results suggest that nectins and afadin are involved in dynamic epithelial remodeling during mouse development...
  20. ncbi Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia
    K Suzuki
    Human Medical Genetics Program, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Nat Genet 25:427-30. 2000
    ..2), which we identify as PVRL1, encoding nectin-1, an immunoglobulin (Ig)-related transmembrane cell-cell adhesion molecule that is part of the ..
  21. ncbi Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes
    Kotaro Wakamatsu
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 282:18173-81. 2007
    ..These results indicate that nectin-1 plays a key role in the expression of loricrin in the epidermis...
  22. pmc Lis1 mediates planar polarity of auditory hair cells through regulation of microtubule organization
    Conor W Sipe
    Department of Cell Biology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Development 140:1785-95. 2013
    ..Together, our results demonstrate that Lis1 mediates the planar polarity of hair cells through regulation of microtubule organization downstream of the tissue polarity pathway...
  23. pmc The cell adhesion gene PVRL3 is associated with congenital ocular defects
    Salil A Lachke
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Genet 131:235-50. 2012
    ..Collectively, these data identify PVRL3 as a critical gene involved in a Nectin-mediated cell-cell adhesion mechanism in human ocular development...
  24. pmc De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity
    Zhufeng Yang
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 140:1774-84. 2013
    ....
  25. doi Nectin-like molecule-5 regulates intimal thickening after carotid artery ligation in mice
    Fumie Kureha
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 33:1206-11. 2013
    ..It is unknown whether nectin-like molecule (Necl)-5, which is overexpressed in cancer cells, is involved in intimal thickening...
  26. pmc Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia
    Navika D Shukla
    Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Mol Vis 18:2711-6. 2012
    ..This study was undertaken to uncover the relative significance of nectin-1 as an entry receptor in corneal infection and HSV-1 spread to the trigeminal ganglia (TG), a site important for HSV-1 latency and recurrent corneal infection...
  27. pmc Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes
    Andrew H Karaba
    Department of Microbiology Immunology, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 109:20649-54. 2012
    ..Thus, the dependence on HVEM is a dividing point between HSV-1 and HSV-2 that evolved to infect areas innervated by different sensory ganglia...
  28. pmc Pathogenesis of neonatal herpes simplex 2 disease in a mouse model is dependent on entry receptor expression and route of inoculation
    Sarah J Kopp
    Department of Microbiology Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Virol 87:474-81. 2013
    ..Our results suggest that differences in receptor expression between adults and newborns may partially explain differences in susceptibility to HSV-2...
  29. pmc Characterization of nectin processing mediated by presenilin-dependent γ-secretase
    Jinsook Kim
    Department of Neuroscience, Georgetown University Medical Center, NW, Washington, District of Columbia, USA
    J Neurochem 119:945-56. 2011
    ..Nectin-3, which forms hetero-trans-dimers with nectin-1, also undergoes intramembrane cleavage mediated by PS1/γ-secretase, suggesting that PS1/γ-secreatse activity regulates synapse formation and remodeling by nectin processing...
  30. doi Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles
    Jocelyn M Mora
    Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom
    Biol Reprod 86:153, 1-14. 2012
    ..Lack of classic markers suggests that GCs are not epithelial. Identification of AJs during GC cuboidalization highlights the importance of AJs in regulating initiation of follicle growth...
  31. pmc Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival
    Rupalatha Maddala
    Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA
    Dev Biol 360:30-43. 2011
    ....
  32. pmc Nectin: an adhesion molecule involved in formation of synapses
    Akira Mizoguchi
    Department of Anatomy and Neurobiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 156:555-65. 2002
    ..These results indicate an important role of the nectin-afadin system in the formation of synapses...
  33. pmc Similar and distinct properties of MUPP1 and Patj, two homologous PDZ domain-containing tight-junction proteins
    Makoto Adachi
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo ku, Kyoto, Japan
    Mol Cell Biol 29:2372-89. 2009
    ....
  34. pmc The murine homolog of human Nectin1delta serves as a species nonspecific mediator for entry of human and animal alpha herpesviruses in a pathway independent of a detectable binding to gD
    L Menotti
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Via San Giacomo, 12, 40126 Bologna, Italy
    Proc Natl Acad Sci U S A 97:4867-72. 2000
    ..of human nectin1delta (mNectin1delta), also known as human poliovirus receptor related 1 (PRR1) or herpesvirus entry mediator C, was cloned and showed a >90% identity with its human counterpart...
  35. ncbi Comparison of murine and human nectin1 binding to herpes simplex virus glycoprotein D (gD) reveals a weak interaction of murine nectin1 to gD and a gD-dependent pathway of entry
    L Menotti
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Via San Giacomo, 12, Bologna, 40126, Italy
    Virology 282:256-66. 2001
    The murine nectin1alpha (mNectin1alpha), a homolog of human nectin1alpha (hNectin1alpha, or PRR1, HveC), mediates the entry of herpes simplex virus (HSV) into cells...
  36. ncbi Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage
    Doo Yeon Kim
    Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, Center for Aging, Genetics and Neurodegeneration, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Biol Chem 277:49976-81. 2002
    ..Similar to nectin-1, other members of the immunoglobulin superfamily involved in synapse formation may also serve as substrates for PS/gamma-secretase-like intramembrane proteolytic activity...
  37. ncbi Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse
    Kyoji Takekuni
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Japan
    J Biol Chem 278:5497-500. 2003
    ..These results indicate that nectin-1 and -3 are involved in the localization of PAR-3 at AJs in the neuroepithelial cells of the embryonic telencephalon...
  38. ncbi Regulation by nectin of the velocity of the formation of adherens junctions and tight junctions
    Tomoyuki Honda
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Osaka University, 565 0871, Suita, Japan
    Biochem Biophys Res Commun 306:104-9. 2003
    ..These results indicate that nectins regulate the velocity of the formation of the E-cadherin-based AJs and the subsequent formation of the claudin-based TJs...
  39. ncbi Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells
    Tatsushi Shingai
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita 565 0871, Osaka, Japan
    J Biol Chem 278:35421-7. 2003
    ..These results indicate the unique localization of Necl-2 and its possible involvement in localization of a transmembrane protein(s) through Pals2...
  40. ncbi Contacts between the commissural axons and the floor plate cells are mediated by nectins
    Noriko Okabe
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    Dev Biol 273:244-56. 2004
    ..These results indicate that the contacts between the commissural axons and the floor plate cells are mediated by the hetero-trans-interaction between nectin-1 and -3 and involved in regulation of the trajectory of the commissural axons...
  41. ncbi A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling
    Hao Ding
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nat Genet 36:1111-6. 2004
    ..Our results also show that PDGF-C signaling is a new pathway in palatogenesis, different from, and independent of, those previously implicated...
  42. ncbi Interaction of integrin alpha(v)beta3 with nectin. Implication in cross-talk between cell-matrix and cell-cell junctions
    Yasuhisa Sakamoto
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka 565 0871, Japan
    J Biol Chem 281:19631-44. 2006
    ..Thus, integrin alpha(v)beta3 and nectin play pivotal roles in the cross-talk between cell-matrix and cell-cell junctions and the formation of cadherin-based AJs...
  43. doi Microphthalmia and lack of vitreous body in transgenic mice expressing the first immunoglobulin-like domain of nectin-1
    Kazuhiko Yoshida
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Graefes Arch Clin Exp Ophthalmol 246:543-9. 2008
    ..The purpose of this study is to examine functions of the extracellular domains of nectin-1 in eye development using transgenic technology...
  44. pmc Alteration of medial-edge epithelium cell adhesion in two Tgf-beta3 null mouse strains
    Elena Martínez-Sanz
    Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain
    Differentiation 76:417-30. 2008
    ..We thus provide insight into the molecular bases of this important process and the cleft palate presented by Tgf-beta3 null mutant mice...
  45. doi Cooperation of nectin-1 and nectin-3 is required for normal ameloblast function and crown shape development in mouse teeth
    Toshiyuki Yoshida
    Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 239:2558-69. 2010
    ..These results suggest that heterophilic interaction between nectin-1 and nectin-3 recruits desmosomal junctions, and that these are required for proper enamel formation...
  46. pmc Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis
    PAUL R BRAKEMAN
    Division of Pediatric Nephrology, Department of Pediatrics, University of California, Box 0748, San Francisco, California 94143 0748, USA
    Am J Physiol Renal Physiol 296:F564-74. 2009
    ....
  47. doi Nectins establish a checkerboard-like cellular pattern in the auditory epithelium
    Hideru Togashi
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Science 333:1144-7. 2011
    ..When cells expressing either nectin-1 or -3 were cocultured, they arranged themselves into a mosaic pattern. Thus, nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia...