Genomes and Genes
Gene Symbol: Ptprd
Description: protein tyrosine phosphatase, receptor type, D
Alias: 1110002J03Rik, 3000002J10Rik, B230219D21Rik, R-PTP-delta, receptor-type tyrosine-protein phosphatase delta
- Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanomaDavid A Solomon
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Washington, District of Columbia 20057, USA
Cancer Res 68:10300-6. 2008..screen for copy number changes in glioblastoma multiforme (GBM), we detected a high frequency of deletions of the PTPRD gene, which encodes a receptor protein tyrosine phosphatase at chromosome 9p23-24.1...
- Impaired learning with enhanced hippocampal long-term potentiation in PTPdelta-deficient miceN Uetani
Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
EMBO J 19:2775-85. 2000..To our knowledge, this is the first report of a specific PTP involved in the regulation of synaptic plasticity or in the processes regulating learning and memory...
- RPTP delta and the novel protein tyrosine phosphatase RPTP psi are expressed in restricted regions of the developing central nervous systemL Sommer
Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena 91125, USA
Dev Dyn 208:48-61. 1997..5, the reciprocal expression patterns of RPTP delta and RPTP psi are consistent with a sequential function, RPTP psi exerting its activity in undifferentiated progenitor cells and RPTP delta functioning during neuronal differentiation...
- MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineageK Mizuno
Tokyo Metropolitan Institute for Neuroscience, Japan
Mol Cell Biol 13:5513-23. 1993..Finally, the MPTP delta locus was tightly linked to the brown (b) locus on mouse chromosome 4...
- Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalonDerek Spieler
Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
Genome Res 24:592-603. 2014..Thus, in vivo and in vitro analysis of a common SNP with small effect size showed allele-dependent function in the prospective basal ganglia representing the first neurodevelopmental region implicated in RLS. ..
- Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesisBerenice Ortiz
Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065 Human Oncology and Pathogenesis Program
Proc Natl Acad Sci U S A 111:8149-54. 2014b>PTPRD, which encodes the protein tyrosine phosphatase receptor-δ, is one of the most frequently inactivated genes across human cancers, including glioblastoma multiforme (GBM)...
- Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesisBerenice Ortiz
Gerstner Sloan Kettering Graduate School, Memorial Sloan Kettering Cancer Center, New York, NY, USA Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Oncotarget 5:6976-82. 2014b>PTPRD encodes the protein tyrosine phosphatase receptor type D and is frequently inactivated across many human cancers. Despite its frequent inactivation, it is unknown whether loss of PTPRD promotes tumorigenesis in vivo...
- Chondroitin Sulfate Proteoglycans Negatively Modulate Spinal Cord Neural Precursor Cells by Signaling Through LAR and RPTPσ and Modulation of the Rho/ROCK PathwayScott M Dyck
Department of Physiology and Pathophysiology, Regenerative Medicine Program, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Stem Cells 33:2550-63. 2015..Our work provide novel evidence uncovering how upregulation of CSPGs challenges the response of NPCs in their post-SCI niche and identifies new therapeutic targets for enhancing NPC-based therapies for SCI repair...
- Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelinationQ Zhu
Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40292, USA
Neuroscience 308:106-14. 2015..In the present study, our results revealed that protein tyrosine phosphatase, receptor type D (PTPRD) was initially expressed in mature neurons in embryonic CNS, and later in oligodendroglial cells at postnatal ..
- Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous systemMaria Shishikura
Department of Molecular Pharmacology and Neurobiology, Graduate School of Medicine, Yokohama City University, Yokohama, Kanagawa 236 0004, Japan Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
Brain Res 1642:244-54. 2016..Golgi-impregnation confirmed the poor dendritic growth of homozygous mitral cells. These results suggest that PTPδ may localize in axons as well as in dendrites to regulate their elaboration in the central nervous system. ..
- Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion moleculeTomoyuki Yoshida
Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Neurosci 32:2588-600. 2012..Thus, IL-1RAcP represents an interesting molecular link between immune systems and synapse formation in the brain...
- IL-1 receptor accessory protein-like 1 associated with mental retardation and autism mediates synapse formation by trans-synaptic interaction with protein tyrosine phosphatase δTomoyuki Yoshida
Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
J Neurosci 31:13485-99. 2011..Our findings raise an intriguing possibility that the impairment of synapse formation may underlie certain forms of MR and autism as a common pathogenic pathway shared by these mental disorders...
- Mammalian motoneuron axon targeting requires receptor protein tyrosine phosphatases sigma and deltaNoriko Uetani
McGill Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
J Neurosci 26:5872-80. 2006....
- Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome"Robert Karisch
Department of Medical Biophysics, University of Toronto, Toronto M5G 2M9, ON, Canada
Cell 146:826-40. 2011....
- Differential gene expression in migrating cortical interneurons during mouse forebrain developmentClare Faux
Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
J Comp Neurol 518:1232-48. 2010..These data therefore provide a framework for future studies aimed at elucidating the complexities of interneuron migration and, in turn, may reveal important genes that are related to the development of specific neurological disorders...
- Protein tyrosine phosphatases expression during development of mouse superior colliculusJacqueline Reinhard
Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology, Ruhr University Bochum, Universitaetsstr 150, 44780, Bochum, Germany
Exp Brain Res 199:279-97. 2009....
- Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatasesNoriko Uetani
Goodman Cancer Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada
J Clin Invest 119:924-35. 2009..Together, these results suggest that ureter positioning is controlled by the opposing actions of Ret and LAR family phosphatases regulating apoptosis-mediated tissue morphogenesis...
- Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mappingHeena V Lad
Social, Genetic and Developmental Psychiatry Centre PO82, Institute of Psychiatry, King s College London, London, SE5 8AF, United Kingdom
Mamm Genome 18:482-91. 2007..A second trial of the test has greater duration of immobility and a completely different genetic profile. Frequency of mobility is also an independent phenotype, with a distal chromosome 1 locus...
- Differences in nuclear signaling by leukemia inhibitory factor and interferon-gamma: the role of STAT proteins in regulating vasoactive intestinal peptide gene expressionA J Symes
Department of Neurology, Massachusetts General Hospital, Boston 02114, USA
J Neurochem 65:1926-33. 1995..These findings show that regions within the CyRE distinct from the STAT site are important to the LIF-dependent regulation of VIP gene expression and enable the CyRE to respond in a cell-specific and cytokine-specific manner...
- Role of the different isoforms of cyclooxygenase and nitric oxide synthase during gastric ulcer healing in cyclooxygenase-1 and -2 knockout miceAdrian Schmassmann
Department of Clinical Research, University of Berne, Switzerland
Am J Physiol Gastrointest Liver Physiol 290:G747-56. 2006..As counterregulatory mechanisms, mRNA of COX and NOS isoforms were increased during healing in COX-impaired mice...
- Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4Rosa Gonzalez-Quevedo
Program in Epithelial Biology, School of Medicine, Stanford University, Stanford, CA 94305, USA
J Cell Biol 168:453-63. 2005..MIM-dependent cytoskeletal changes can be inhibited using a soluble RPTPdelta-D2 domain. Our data suggest that the hedgehog-responsive gene MIM cooperates with RPTP to induce cytoskeletal changes...
- Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate geneChristoph Fehr
Portland Alcohol Research Center and Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97201, USA
J Neurosci 22:3730-8. 2002..These analyses, and evidence using interval-specific congenic lines, show that alcohol withdrawal severity is genetically correlated with MPDZ status, indicating that MPDZ variants may influence alcohol withdrawal liability...
- Defects in thalamocortical axon pathfinding correlate with altered cell domains in Mash-1-deficient miceR Tuttle
Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
Development 126:1903-16. 1999..In addition, these findings support the hypothesis that ventral telencephalic neurons and their axons guide TCAs through ventral thalamus and into ventral telencephalon...
- Developmental expression of the cell adhesion molecule-like protein tyrosine phosphatases LAR, RPTPdelta and RPTPsigma in the mouseR Q Schaapveld
Department of Cell Biology and Histology, Institute of Cellular Signalling, University of Nijmegen, Adelbertusplein 1, 6525 EK, Nijmegen, The Netherlands
Mech Dev 77:59-62. 1998..RPTP sigma is found in (neuro)ectodermal, neural crest-derived systems and in mesoderm-derived tissues. The expression pattern of RPTP sigma largely parallels that of RPTP sigma, in concordance with their proposed evolutionary history..
- The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigmaM J Wallace
Division of Respiratory Research, The Hospital for Sick Children, Toronto, Ontario, Canada
Mol Cell Biol 18:2608-16. 1998....
- Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrowK Huang
Laboratory of Mammalian Genes and Development, NICHD, NIH, Bethesda, Maryland 20892, USA
Oncogene 13:1567-73. 1996..The high level expression of PTP-K1 mRNA in bone marrow suggests that PTP-K1 may be involved in signal transduction in growth and differentiation of hematopoietic cells...
- Identification of protein tyrosine phosphatases expressed in murine male germ cellsY Kaneko
Department of Clinical Molecular Biology, Kyoto University Faculty of Medicine, Japan
Biochem Biophys Res Commun 197:625-31. 1993....
- Developmental regulation of gene expression for the MPTP delta isoforms in the central nervous system and the immune systemK Mizuno
Tokyo Metropolitan Institute for Neuroscience, Japan
FEBS Lett 355:223-8. 1994..An in situ hybridization study showed that MPTP delta mRNA is diffusely expressed throughout the spleen, but its expression in the thymus is restricted to the medullary region...
- A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brainW Hendriks
Department of Cell Biology and Histology, University of Nijmegen, The Netherlands
Biochem J 305:499-504. 1995..This suggests a role for PTP-SL in cell-cell signalling processes in the brain...
- mRNA expression of two transmembrane protein tyrosine phosphatases is modulated by growth factors and growth arrest in 3T3 fibroblastsJ W Celler
Max Planck Society, Faculty of Medicine, Friedrich Schiller University, Jena, Germany
Biochem Biophys Res Commun 209:614-21. 1995..In cells whose growth was arrested by contact inhibition at high cell density or by serum starvation at low cell density mRPTP-sigma mRNA level increased. The possible implications of these mRNA expression patterns are discussed...