Genomes and Genes
Gene Symbol: Ptpn6
Description: protein tyrosine phosphatase, non-receptor type 6
Alias: 70Z-SHP, Hcph, PTPTY-42, Ptp1C, SH-PTP1, SHP-1, hcp, tyrosine-protein phosphatase non-receptor type 6, SH2 phosphatase 1, hematopoietic cell protein-tyrosine phosphatase, motheaten, protein-tyrosine phosphatase 1C
Publications122 found, 100 shown here
- Restricted CDR3 length of the heavy chain is characteristic of six randomly isolated disease-associated VH J558+ IgM autoantibodies in lupus prone motheaten miceV Lipsanen
Department of Pathobiology, University of Guelph, Ontario, Canada
Int Immunol 9:655-64. 1997..autoantibodies (AAb), we compared the genetic and structural characteristics of IgM AAb from autoimmune prone motheaten (mev) mice with natural autoantibodies (NAAb) from normal background C57/BL6 strain...
- The major SHP-1-binding, tyrosine-phosphorylated protein in macrophages is a member of the KIR/LIR family and an SHP-1 substrateK L Berg
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
Oncogene 17:2535-41. 1998..a substrate of SHP-1 in vitro and is hyperphosphorylated on tyrosine in SHP-1 deficient macrophages from viable-motheaten mice...
- Absence of CD5 dramatically reduces progression of pulmonary inflammatory lesions in SHP-1 protein-tyrosine phosphatase-deficient 'viable motheaten' miceMelissa J Joliat
The Jackson Laboratory, Bar Harbor, ME 04609, USA
J Autoimmun 18:105-17. 2002Mice homozygous for the viable motheaten (Hcph(me-v)) mutation are deficient in SHP-1 protein-tyrosine phosphatase, resulting in severe systemic autoimmunity and immune dysfunction...
- SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RACAnita M Kant
Herman B Wells Center for Pediatrics Research, Indiana University School of Medicine, Indianapolis 46202, USA
Blood 100:1852-9. 2002....
- Lipopolysaccharide-induced osteoclastogenesis in Src homology 2-domain phosphatase-1-deficient viable motheaten miceShin ichi Hayashi
Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, 86 Nishi Machi, Yonago, Tottori 683 8503, Japan
Endocrinology 145:2721-9. 2004..mature osteoclasts were generated from protein tyrosine phosphatase Src homology 2-domain phosphatase-1-defective Hcph(me-v)/Hcph(me-v) (me(v)/me(v)) bone marrow cells in the presence of M-CSF and LPS without addition of RANKL in ..
- Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13T L Yi
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
Mol Cell Biol 12:836-46. 1992..Importantly, the human gene maps to chromosome 12 region p12-p13. This region is associated with rearrangements in approximately 10% of cases of acute lymphocytic leukemia in children...
- Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6M A Ansari-Lari
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
Genome Res 8:29-40. 1998....
- Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesisZhiyuan Zhang
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
J Immunol 171:3620-6. 2003..Therefore, SHP-1 plays a role in signals downstream of RANKL by recruitment to the complex containing TRAF6 and these observations may help to understand the mechanism of osteoporosis in Me(v)/Me(v) mice...
- Identification of leishmania fructose-1,6-bisphosphate aldolase as a novel activator of host macrophage Src homology 2 domain containing protein tyrosine phosphatase SHP-1Devki Nandan
Department of Medicine, Division of Infectious Diseases, 2733 Heather Street, Heather Pavilion East, Room 452 D, Vancouver, BC, Canada V5Z 3J5
Biochem Biophys Res Commun 364:601-7. 2007..Collectively, these data show that leishmania aldolase is a novel SHP-1 binding and activating protein that contributes to macrophage dysfunction...
- IL-6 production is positively regulated by two distinct Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1)-dependent CCAAT/enhancer-binding protein β and NF-κB pathways and an SHP-1-independent NF-κB pathway in lipopolysaccharide-stimulated bDorothy Rego
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario KIH 8M5, Canada
J Immunol 186:5443-56. 2011..macrophages (BMDMs) from normal and Src homology domain 2-containing tyrosine phosphatase-1 (SHP-1)-deficient Motheaten (me/me) mice revealed a dramatic suppression of IL-6 transcript and protein in me/me BMDMs after LPS stimulation...
- Motheaten, an immunodeficient mutant of the mouse. II. Depressed immune competence and elevated serum immunoglobulinsL D Shultz
J Immunol 116:936-43. 1976Mice homozygous for the recessive mutation motheaten (me) are deficient in capacity for immune response but show an elevated level of serum immunoglobulins...
- Pulmonary pathology of the motheaten mouseJ M Ward
Vet Pathol 15:170-8. 1978Mice, homozygous for the motheaten gene, developed an unusual pneumonia that was the cause of natural death of mice by 7 weeks of age...
- Motheaten, an immunodeficient mutant of the mouse. I. Genetics and pathologyM C Green
J Hered 66:250-8. 1975A new recessive mutation, motheaten (me), is on chromosome 6, 21.9 +/- 4.3 recombination units distal to white (Miwh)...
- Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequencesR J Matthews
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110
Mol Cell Biol 12:2396-405. 1992..These two additional members of the PTPase family accentuate the variety of PTPase structures and indicate the potential diversity of function for intracellular tyrosine phosphatases...
- The interaction of the xid and me genesC L Scribner
J Immunol 138:3611-7. 1987The murine "motheaten" (me) mutation has been bred onto the NFS background and combined with the X-linked immunodeficiency (xid) mutation to investigate the effect of the xid-induced B cell maturational block on the widespread ..
- "Viable motheaten," a new allele at the motheaten locus. I. PathologyL D Shultz
Am J Pathol 116:179-92. 1984A new spontaneous autosomal recessive mutation has recently occurred at the motheaten (me) locus on Chromosome 6 in strain C57BL/6J mice...
- Mutations in mice that influence natural killer (NK) cell activityE A Clark
Immunogenetics 12:601-13. 1981..loci that reduce NK-cell activity in the homozygous state were identified, including beige (bg), hairless (hr), motheaten (me), obese (ob), steel (Sl) and, to lesser extent, dominant spotting (W)...
- Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas-mediated apoptosisX Su
Department of Medicine, University of Alabama at Birmingham, USA
Immunity 2:353-62. 1995..The time course and level of dephosphorylation were correlated with increased hematopoietic cell protein tyrosine phosphatase (HCP) activity, but not with the activity of two other tyrosine phosphatases...
- Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selectionJ G Cyster
Department of Microbiology and Immunology, Beckman Center, Stanford University School of Medicine, California 94305, USA
Immunity 2:13-24. 1995b>Motheaten viable (mev) mice are deficient in the cytosolic protein tyrosine phosphatase, PTP1C, and exhibit severe B cell immunodeficiency and autoantibody production...
- Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten miceM Kozlowski
Department of Medicine, University of Toronto, Ontario, Canada
J Exp Med 178:2157-63. 1993..containing a COOH-terminal catalytic and two NH2-terminal Src homology 2 (SH2) domains, have been identified in motheaten (me) and viable motheaten (mev) mice and are associated with severe hemopoietic dysregulation...
- Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) geneL D Shultz
Jackson Laboratory, Bar Harbor, Maine 04609
Cell 73:1445-54. 1993Mice homozygous for the recessive allelic mutation motheaten (me) or viable motheaten (mev) on chromosome 6 develop severe defects in hematopoiesis...
- Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase geneH W Tsui
Toronto Hospital, Ontario, Canada
Nat Genet 4:124-9. 1993Mice with the recessive motheaten (me) or the allelic viable motheaten (mev) mutations express a severe autoimmune and immunodeficiency syndrome...
- Signalling by the W/Kit receptor tyrosine kinase is negatively regulated in vivo by the protein tyrosine phosphatase Shp1R F Paulson
Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Nat Genet 13:309-15. 1996..murine Dominant white spotting (W) locus and the Shp1 protein tyrosine phosphatase, the product of the murine motheaten (me) gene...
- Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1H Jiao
Department of Cancer Biology, The Cleveland Clinic Foundation Research Institute, Ohio 44195, USA
Mol Cell Biol 16:6985-92. 1996..as shown by its constitutive association with the Tyk2 kinase and the hyperphosphorylation of Jak kinases in the motheaten cells that lack functional SHP-1...
- Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphataseM C Nakamura
Department of Medicine, University of California, San Francisco 94143, USA
J Exp Med 185:673-84. 1997..tyrosine phosphatase SHP-1, and that Ly-49A function is impaired in NK cells from SHP-1 mutant viable motheaten mice and from SHP-1-deficient motheaten mice...
- Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiencyL D Shultz
Jackson Laboratory, Bar Harbor, ME 04609, USA
Trends Biotechnol 15:302-7. 1997..Mutations at the 'motheaten' locus result in severe immunological dysfunction due to disruption of the structural gene encoding Src-homology ..
- Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selectionR J Cornall
Howard Hughes Medical Institute and Department of Microbiology and Immunology, Stanford University, Palo Alto, California 94305, USA
Immunity 8:497-508. 1998..The biochemical basis of this complex trait involves a pathway requiring Lyn to phosphorylate CD22 and recruit SHP-1 to the CD22/BCR complex...
- Functional consequences of the SHP-1 defect in motheaten viable mice: role of NF-kappa BA R Khaled
Department of Molecular Genetics and Microbiology, University of Florida, Gainesville 32610, USA
Cell Immunol 185:49-58. 1998..of the src-homology domain-1 protein (SHP-1) defect, we examined cytokine production and NF-kappa B activity in motheaten viable (Mev) mice...
- High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophagesA Veillette
McGill Cancer Centre, McGill University, Montreal, Quebec, Canada H3G 1Y6
J Biol Chem 273:22719-28. 1998..Taken together, these findings indicate that SHPS-1 is likely to play a significant role in macrophages, at least partially as a consequence of its capacity to recruit SHP-1...
- The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophagesT I Roach
Department of Pathology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63130, USA
Curr Biol 8:1035-8. 1998..The viable motheaten (Hcphme-v) mutant mice (mev) suffer from progressive inflammation due to a deficiency of SHP-1 enzyme activity [..
- The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cellsM Huber
McGill Cancer Centre, Medicine, and Oncology, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 274:335-44. 1999..Together, these results indicate that both SHP-1 and SHP-2 interact with the Bgp1 cytoplasmic domain via ITIM-like sequences. Furthermore, they reveal that the C-terminal amino acids of Bgp1 are critical for these interactions...
- Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49BL L Wang
Howard Hughes Medical Institute, Rheumatology Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 162:1318-23. 1999..Thus, gp49B signaling involves SHP-1, and this association is dependent on tyrosine phosphorylation of the gp49B ITIMs, and an intact SHP-1 carboxyl SH2 domain...
- TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1K G Johnson
Department of Medicine, University of Wales College of Medicine, Cardiff, United Kingdom
J Immunol 162:3802-13. 1999An examination of thymocytes and peripheral T cells from SHP-1-deficient motheaten mice possessing a transgenic MHC class I-restricted TCR has implicated SHP-1 in regulating TCR signaling thresholds at three checkpoints in T cell ..
- Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selectionJ Zhang
Department of Immunology, University of Toronto, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
J Immunol 163:3012-21. 1999..analysis of T cell development in H-Y TCR transgenic mice rendered SHP-1 deficient by introduction of the viable motheaten mutation or a dominant negative SHP-1-encoding transgene...
- The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholdsJ D Carter
Department of Microbiology, University of Virginia, HSC, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
Int Immunol 11:1999-2014. 1999..10 TCR transgene onto the motheaten background, which lacks SHP-1 expression...
- Impaired natural killing of MHC class I-deficient targets by NK cells expressing a catalytically inactive form of SHP-1B Lowin-Kropf
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
J Immunol 165:1314-21. 2000..A similar NK cell phenotype is observed in viable motheaten (mev) mice, which show reduced SHP-1 activity due to a mutation in the Shp-1 gene...
- Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten miceJ Kruger
Division of Respirology, The Toronto General Hospital Research Institute of the University Health Network, Toronto, Ontario, Canada
J Immunol 165:5847-59. 2000..however, implied by the overexpansion and inappropriate activation of granulocyte populations in SHP-1-deficient motheaten (me/me) and motheaten viable (me(v)/me(v)) mice...
- A novel role for protein tyrosine phosphatase shp1 in controlling glial activation in the normal and injured nervous systemA Horvat
Department of Neuromorphology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
J Neurosci 21:865-74. 2001..These results emphasize that SHP1 as a part of different signaling pathways plays an important role in the global regulation of astrocytic and microglial activation in the normal and injured CNS...
- CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1K L Otipoby
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
J Biol Chem 276:44315-22. 2001..We propose that the cytoplasmic tail of CD22 contains two domains that regulate signal transduction pathways initiated by the BCR and B cell fate...
- Lack of the protein tyrosine phosphatase SHP-1 results in decreased numbers of glia within the motheaten (me/me) mouse brainC A Wishcamper
Department of Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USA
J Comp Neurol 441:118-33. 2001Mice that are homozygous for the autosomal recessive motheaten allele (me/me) lack the protein tyrosine phosphatase SHP-1...
- src homology 2 domain-containing tyrosine phosphatase SHP-1 controls the development of allergic airway inflammationTohru Kamata
Department of Molecular Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan
J Clin Invest 111:109-19. 2003..and in the development of Th2-dependent allergic airway inflammation by using a natural SHP-1 mutant, the motheaten mouse...
- Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP-1-deficient micePaul T Massa
Department of Neurology, Neuroscience Program, SUNY Upstate Medical University, Syracuse, New York 13066, USA
J Neurosci Res 77:15-25. 2004..express the protein tyrosine phosphatase SHP-1 and that myelin formation was decreased in SHP-1-deficient motheaten mice compared to that in normal littermates...
- Abnormal Th1 cell differentiation and IFN-gamma production in T lymphocytes from motheaten viable mice mutant for Src homology 2 domain-containing protein tyrosine phosphatase-1Wen Mei Yu
Department of Hematopoiesis, Jerome H Holland Laboratory for the Biomedical Sciences, American Red Cross, Rockville, MD 20855, USA
J Immunol 174:1013-9. 2005..Compared with the wild-type control, anti-CD3-activated mouse T lymphocytes carrying the motheaten viable mutation in the SHP-1 gene produced a significantly increased amount of IFN-gamma in the presence of IL-..
- TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1Il Kyoo Park
Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
J Immunol 175:5666-74. 2005..Together, these data show that TGF-beta1 suppresses IFN-gamma signaling and transcriptional responses in CD4+ T cells through the PTP Shp-1...
- Lipopolysaccharide-activated SHP-1-deficient motheaten microglia release increased nitric oxide, TNF-alpha, and IL-1betaJie Zhao
Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy and Allied Health Sciences, University of Montana, Missoula, MT 59812, USA
Glia 53:304-12. 2006..abnormal microglial activation accompanied by increased neuronal loss within the auditory brainstem occurs in motheaten (me/me) mice deficient in the protein tyrosine phosphatase SHP-1...
- Motheaten (me/me) mice deficient in SHP-1 are less susceptible to focal cerebral ischemiaCeline A Beamer
Center for Environmental Health Sciences, School of Pharmacy and Allied Health Sciences, University of Montana, Missoula 59812 1552, USA
J Neurosci Res 83:1220-30. 2006....
- The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasisMarie Julie Dubois
Department of Anatomy Physiology and Lipid Research Unit, Laval University Hospital Research Center, 2705 Laurier Boulevard, Quebec, Quebec G1V 4G2, Canada
Nat Med 12:549-56. 2006..Here we show that Ptpn6(me-v/me-v) (also known as viable motheaten) mice bearing a functionally deficient SHP-1 protein are markedly glucose tolerant and insulin sensitive as ..
- B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunityLily I Pao
Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
Immunity 27:35-48. 2007Spontaneous loss-of-function mutations in the protein-tyrosine phosphatase Shp1 cause the motheaten phenotype, characterized by widespread inflammation and autoimmunity...
- Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammationYou Sook Cho
Division of Allergy and Clinical Immunology, Johns Hopkins Asthma Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Respir Cell Mol Biol 39:412-9. 2008..the effect of oxidative stress on the development of allergic airway inflammation in heterozygous viable motheaten (mev/+) mice deficient of SHP-1. Wild-type (WT) and mev/+ mice were compared in this study...
- Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial triggerBen A Croker
Department of Genetics, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:15028-33. 2008..hypomorphic allele of Ptpn6, which encodes the tyrosine phosphatase SHP1, mutated in mice with the classical motheaten alleles me and me-v. Inflammation and autoimmunity caused by SHP1 deficiency are thus conditional...
- A critical role of SHP-1 in regulation of type 2 inflammation in the lungSun Young Oh
Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Respir Cell Mol Biol 40:568-74. 2009..we sought to define the function of SHP-1 in the lung by characterizing the pulmonary inflammation of viable motheaten (mev) mice, and to investigate the molecular mechanisms involved...
- Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5Wenbin Xiao
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Cancer Cell 16:161-71. 2009..The same mechanism for malignant transformation seems to be operative in other human lymphoid and myeloid malignancies. Thus, PLC-beta3 is likely a tumor suppressor...
- Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activityAlexander Nyström
Department of Pathology, Anatomy, and Cell Biology, and Cancer Cell Biology and Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
Blood 114:4897-906. 2009..Our results show that SHP-1 is an essential mediator of endorepellin activity and discover a novel functional interaction between the integrin alpha2 subunit and SHP-1...
- Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-SrcMario M Müller
Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden
J Cell Biol 187:569-81. 2009..These data suggest that transmembrane signaling by CEACAM1 operates by alteration of the monomer/dimer equilibrium, which leads to changes in the SHP-2/c-Src-binding ratio...
- SHP-1 deficient mast cells are hyperresponsive to stimulation and critical in initiating allergic inflammation in the lungLi Zhang
Division of Allergy and Clinical Immunology, The Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA
J Immunol 184:1180-90. 2010..survival, and functional responses to stimulation using bone marrow-derived mast cells from viable motheaten (mev) mice...
- The tyrosine phosphatase, SHP-1, is involved in bronchial mucin production during oxidative stressMin Kyoung Jang
Asan Institute for Life Science, Seoul, Republic of Korea
Biochem Biophys Res Commun 393:137-43. 2010..Notably, mucin production was enhanced in the airway epithelia of mev/+ mice exposed to oxidative stress. Our results clearly indicate that SHP-1 plays an important role in airway mucin production through regulating oxidative stress...
- SHP-1 in T cells limits the production of CD8 effector cells without impacting the formation of long-lived central memory cellsCarla C Fowler
Department of Immunology, School of Medicine, University of Washington, Seattle, WA 98195 6425, USA
J Immunol 185:3256-67. 2010..Analysis of CD8 T cells from motheaten mice, which are globally deficient in SHP-1, proved problematic due to cell-extrinsic effects of SHP-1 ..
- Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like diseaseWenbin Xiao
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Blood 116:6003-13. 2010..Therefore, we identify a novel Lyn/PLC-β3-mediated regulatory mechanism of SHP-1 and Stat5 activities...
- Prep1 controls insulin glucoregulatory function in liver by transcriptional targeting of SHP1 tyrosine phosphataseFrancesco Oriente
Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Universita degli Studi di Napoli Federico II, Naples, Italy
Diabetes 60:138-47. 2011..We investigated the function of the Prep1 gene in insulin-dependent glucose homeostasis in liver...
- Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptorHao Pan
City of Hope Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope, 1450 E Duarte Road, Duarte, CA 91010, USA
Immunity 33:620-31. 2010..Thus, CEACAM1 acted as a coinhibitory receptor for G-CSFR regulating granulopoiesis and host innate immune response to bacterial infections...
- Spontaneous insertion of a b2 element in the ptpn6 gene drives a systemic autoinflammatory disease in mice resembling neutrophilic dermatosis in humansAndrew B Nesterovitch
Department of Dermatology, Rush University Medical Center, Chicago, Illinois, USA
Am J Pathol 178:1701-14. 2011..onset was delayed, and the clinical phenotype was milder than the phenotypes of other Ptpn6-mutants described in motheaten (me, mev) mice; we designated this new genotype as Ptpn6(meB2/meB2) and the phenotype as meB2...
- Phospholipase C-β3 regulates FcɛRI-mediated mast cell activation by recruiting the protein phosphatase SHP-1Wenbin Xiao
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
Immunity 34:893-904. 2011..Thus, we have defined a PLC-β3- and SHP-1-mediated signaling pathway for FcɛRI-mediated cytokine production...
- Spontaneous eosinophilic nasal inflammation in a genetically-mutant mouse: comparative study with an allergic inflammation modelSeok Hyun Cho
Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 7:e35114. 2012..These mice lack the enzyme SHP-1 that down-regulates the IL-4Rα/stat6 signaling pathway. We compared nasal inflammation and inflammatory mediators in SHP-1 deficient mice (mev) and an ovalbumin-induced nasal allergy model...
- Dendritic cell-specific ablation of the protein tyrosine phosphatase Shp1 promotes Th1 cell differentiation and induces autoimmunityTetsuya Kaneko
Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma 371 8512, Japan
J Immunol 188:5397-407. 2012..Moreover, aged mutant mice developed glomerulonephritis and interstitial pneumonitis together with increased serum concentrations of autoantibodies. Shp1 is thus a key regulator of DC functions that protects against autoimmunity...
- B cell receptor signal transduction in the GC is short-circuited by high phosphatase activityAshraf M Khalil
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Science 336:1178-81. 2012..Furthermore, SHP-1 was required for GC maintenance. Intriguingly, GC B cells in the cell-cycle G(2) period regained responsiveness to BCR stimulation. These data have implications for how higher-affinity B cells are selected in the GC...
- Abrogation of SRC homology region 2 domain-containing phosphatase 1 in tumor-specific T cells improves efficacy of adoptive immunotherapy by enhancing the effector function and accumulation of short-lived effector T cells in vivoIngunn M Stromnes
Department of Immunology, University of Washington, Seattle, WA 98195, USA
J Immunol 189:1812-25. 2012..These studies suggest that abrogating SHP-1 in effector T cells may improve the efficacy of tumor elimination by T cell therapy without affecting the ability of the effector cells to persist and provide a long-term response...
- Distinct roles for neutrophils and dendritic cells in inflammation and autoimmunity in motheaten miceClare L Abram
Department of Laboratory Medicine and the Program in Immunology, University of California, San Francisco 94143, USA
Immunity 38:489-501. 2013The motheaten mouse has long served as a paradigm for complex autoimmune and inflammatory disease. Null mutations in Ptpn6, which encodes the nonreceptor protein-tyrosine phosphatase Shp1, cause the motheaten phenotype...
- Shp1 regulates T cell homeostasis by limiting IL-4 signalsDylan J Johnson
Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Center, University Health Network, Toronto, ON M5G 2C1, Canada
J Exp Med 210:1419-31. 2013..Mutations in Ptpn6, which encodes Shp1, result in widespread inflammation and premature death, known as the motheaten (me) phenotype...
- Phenotypic and functional effects of the motheaten gene on murine B and T lymphocytesW F Davidson
J Immunol 122:884-91. 1979..It remains to be determined what the basic deficiency in me/me mice is and whether it affects primarily B cells or all lymphoid cells...
- Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1U Lorenz
Molecular Medicine Unit, Beth Israel Hospital, Boston, Massachusetts, USA
J Exp Med 184:1111-26. 1996..between the RTK c-Kit, encoded at the W locus, and the SH2-containing non-transmembrane PTP SHP1, encoded at the motheaten (me) locus (1)...
- Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone densityS Umeda
Jackson Laboratory, Bar Harbor, Maine Kumamoto University of Medicine, Kumamoto, Japan
Am J Pathol 155:223-33. 1999Mice homozygous for the motheaten (Hcphme) or viable motheaten (Hcphme-v) mutations are deficient in functional SHP-1 protein-tyrosine phosphatase and show severe defects in hematopoiesis...
- Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cellsKazuyasu Chihara
Division of Microbiology, Department of Pathological Sciences, University of Fukui, Japan
Genes Cells 16:1133-45. 2011..These findings suggest that 3BP2 directly interacts with Tyr(564) -phosphorylated form of SHP-1 and positively regulates the function of SHP-1 in FcεRI-mediated signaling in mast cells...
- IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responsesMeryem Aloulou
INSERM U699, Paris, France
Blood 119:3084-96. 2012..These data support a new mechanism of action for IVIg and demonstrate the therapeutic potential of FcγRIIIA targeting in inflammation...
- Intravenous immunoglobulins modulate neutrophil activation and vascular injury through FcγRIII and SHP-1Jung Eun Jang
Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
Circ Res 110:1057-66. 2012..Intravenous immunoglobulin (IVIG) has been shown to have a beneficial effect in systemic inflammatory disorders; however, the mechanisms underlying IVIG's inhibitory effect on neutrophil recruitment and activation are not understood...
- Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathyAkira Mima
Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA
FASEB J 26:2963-74. 2012..Hyperglycemia and diabetes can cause glomerular podocyte apoptosis and endothelial dysfunction partly due to increased PKCδ/p38 MAPK activation and the expression of SHP-1 to cause VEGF resistance, independent of NF-κB activation...
- Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6T Yi
Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
Genomics 14:793-5. 1992Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells...
- Effect of genetically determined immunodeficiency on epidermal dendritic cell populations in C57BL/6J miceE Sprecher
Department of Molecular Virology, Faculty of Medicine, Hebrew University, Jerusalem, Israel
Arch Dermatol Res 282:188-93. 1990..were determined using indirect immunofluorescence microscopy of epidermal whole mounts taken from viable motheaten (mev), nude (nu), and rhino (rhhr) mice...
- Hematologic abnormalities of the immunodeficient mouse mutant, viable motheaten (mev)G Van Zant
Department of Cell Biology and Anatomy, Texas Tech University Health Sciences Center, Lubbock 79430
Exp Hematol 17:81-7. 1989We have studied the hematopoietic system of the immunodeficient mouse mutant, viable motheaten (mev/mev). These mice usually die by 9 weeks of age from severe pneumonitis...
- The viable motheaten (mev) mouse--a new model for arthritisJ Kovarik
Immunology Department, Sandoz Pharma Ltd, Basel, Switzerland
J Autoimmun 7:575-88. 1994..These results indicate the particular sensitivity of this model for efficacy of potentially new therapeutic but non-cytostatic compounds for clinical use...
- Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defectX Su
Department of Medicine, The University of Alabama at Birmingham, AL 35294, USA
J Immunol 156:4198-208. 1996..on the T cell phenotype and apoptosis function in hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice...
- Macrophages from motheaten and viable motheaten mutant mice show increased proliferative responses to GM-CSF: detection of potential HCP substrates in GM-CSF signal transductionH Jiao
Department of Cancer Biology, Cleveland Clinic Research Institute, OH 44195, USA
Exp Hematol 25:592-600. 1997..cell phosphatase (HCP) underlies severe hematopoietic and immunologic abnormalities in mice homozygous for the motheaten and viable motheaten mutations...
- Abnormal development and differentiation of macrophages and dendritic cells in viable motheaten mutant mice deficient in haematopoietic cell phosphataseK Nakayama
Second Department of Pathology, Kumamoto University School of Medicine, Japan
Int J Exp Pathol 78:245-57. 1997In mice homozygous for the 'viable motheaten' (mev) mutation, numbers of macrophage progenitor cells, particularly monocytes, were markedly increased in the bone marrow and spleen...
- SHP-1 phosphatase C-terminus interacts with novel substrates p32/p30 during erythropoietin and interleukin-3 mitogenic responsesW Yang
Department of Cancer Biology, The Lerner Research Institute of The Cleveland Clinic Foundation, Cleveland, OH, USA
Blood 91:3746-55. 1998..as demonstrated by the heightened growth responses to hematopoietic growth factors in hematopoietic cells of motheaten mice, which lack functional SHP-1 expression due to mutations in the SHP-1 gene...
- Genetic analysis of B cell antigen receptor signalingT Kurosaki
Department of Molecular Genetics, Kansai Medical University, Moriguchi, Japan
Annu Rev Immunol 17:555-92. 1999....
- Abnormal chemokine-induced responses of immature and mature hematopoietic cells from motheaten mice implicate the protein tyrosine phosphatase SHP-1 in chemokine responsesC H Kim
Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
J Exp Med 190:681-90. 1999..activities induced by chemokines, we examined the role of SHP-1 in functions of chemokines using viable motheaten (me(v)/me(v)) mice that were deficient in SHP-1...
- The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant miceK Aoki
Department of Orthopaedics, and Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA
Bone 25:261-7. 1999..mutations of the Src homology 2 (SH2) domain-containing tyrosine phosphatase 1 (SHP-1) in mice give rise to the motheaten (me) phenotype...
- SHP-1 variant proteins are absent in motheaten mice despite presence of splice variant transcripts with open reading framesA Martin
Department of Immunology, University of Toronto, Ontario, Canada
Mol Immunol 36:1029-41. 1999b>Motheaten mice have a mutation that causes abnormal splicing of the SHP-1 gene producing transcripts that are out of frame. Thus, motheaten mice cannot produce normal SHP-1 protein...
- Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signallingNicholas R D Paling
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
Biochem J 368:885-94. 2002..These results demonstrate that SHP-1 acts to negatively regulate IL-3-driven survival and proliferation, potentially via regulation of tyrosine phosphorylation of Aic2A and STAT5...
- Decreased expression of Src homology 2 domain-containing protein tyrosine phosphatase 1 reduces T cell activation threshold but not the severity of experimental autoimmune myasthenia gravisCaishu Deng
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
J Neuroimmunol 138:76-82. 2003....
- CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formationDong Hui Chung
Veterans Administration Medical Center and University of California, San Francisco, CA 94121, USA
J Immunol 171:6541-8. 2003..Thus, we define a new family of myeloid receptors, and demonstrate that the first member of this family, CLM-1, is an inhibitory receptor, able to block osteoclastogenesis...
- Dynamic changes in the expression of protein tyrosine phosphatases during preimplantation mouse development: semi-quantification by real-time PCRKentaro T Hara
Graduate School of Frontier Sciences, University of Tokyo, Shinryoiki Seimei Building 302, Kashiwa, Chiba 277 8562, Japan
J Reprod Dev 49:323-8. 2003..This suggests that PTPs are involved in the regulation of growth and differentiation during preimplantation development...
- Cochlear ablation in mice lacking SHP-1 results in an extended period of cell death of anteroventral cochlear nucleus neuronsJie Zhao
Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy and Allied Health Sciences, University of Montana, Missoula, 59812, USA
Hear Res 189:63-75. 2004..These results indicate that activated microglia may participate in determining whether neurons in AVCN live or die following deafferentation...
- Visualization of SHP-1-target interactionChristoph Biskup
Institute of Physiology II, Medical Faculty, Friedrich Schiller University, Drackendorfer Str 1, 07747 Jena, Germany
J Cell Sci 117:5165-78. 2004....
- Deficiency of SHP-1 protein-tyrosine phosphatase in "viable motheaten" mice results in retinal degenerationBonnie L Lyons
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Invest Ophthalmol Vis Sci 47:1201-9. 2006Viable motheaten mutant mice (abbreviated allele symbol me(v)) are deficient in Src-homology 2-domain phosphatase (SHP)-1, a critical negative regulator of signal transduction in hematopoietic cells...
- Loss of Src homology region 2 domain-containing protein tyrosine phosphatase-1 increases CD8+ T cell-APC conjugate formation and is associated with enhanced in vivo CTL functionJean G Sathish
Section of Infection and Immunity, Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff, United Kingdom
J Immunol 178:330-7. 2007..Specifically, T cells from the SHP-1-deficient mouse, motheaten, exhibit a hyperproliferative phenotype when activated by cognate peptide-pulsed APCs...
- Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cellsMélanie Simoneau
Département d Anatomie et Biologie Cellulaire, Faculte de Medecine et des Sciences de la Sante, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
J Biol Chem 283:25544-56. 2008..In conclusion, our results indicate that Cdk2-associated complexes, by targeting SHP-1 for proteolysis, counteract the ability of SHP-1 to block cell cycle progression of IECs...
- Positive and negative regulation of high affinity IgE receptor signaling by Src homology region 2 domain-containing phosphatase 1Kazuko Nakata
Department of Immunology and Signal Transduction, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Science, Fuchu, Tokyo, Japan
J Immunol 181:5414-24. 2008..how SHP-1 regulates mast cell signaling, we established bone marrow-derived mast cells from SHP-1-deficient motheaten and wild-type mice and analyzed downstream signals induced by cross-linking of high affinity IgE receptor, Fc ..
- The Src family kinase, Lyn, suppresses osteoclastogenesis in vitro and in vivoHyun Ju Kim
Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 106:2325-30. 2009..The most pragmatic aspect of our findings is that successful therapeutic inhibition of c-Src, in the context of the osteoclast, will require its stringent targeting...
- Protein tyrosine phosphatases expression during development of mouse superior colliculusJacqueline Reinhard
Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology, Ruhr University Bochum, Universitaetsstr 150, 44780, Bochum, Germany
Exp Brain Res 199:279-97. 2009..Subsequently, the expression patterns of 11 PTPs (TC-PTP, PTP1C, PTP1D, PTP-MEG2, PTP-PEST, RPTPJ, RPTPε, RPTPRR, RPTPσ, RPTPκ and RPTPγ) were further analyzed in detail in ..
- Hippocampal SH2-containing protein-tyrosine phosphatases are involved in extinction of contextual fearTomoko Isosaka
Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Neuroreport 21:554-8. 2010..These findings suggest that SHP1/2 activity in the hippocampus is involved in the control of contextual fear extinction...
- The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cellsTessy Iype
Beirne B Carter Center for Immunology Research, Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA
J Immunol 185:6115-27. 2010..Collectively, our data reveal SHP-1 as a critical modifier of Treg function and a potential therapeutic target for augmenting Treg-mediated suppression in certain disease states...
- Genes that Mediate Tolerance to the Placental AllograftBruce Beutler; Fiscal Year: 2006..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
- A Critical Role for SHP-1 in Retinal DegenerationBonnie Lyons; Fiscal Year: 2006..The viable motheaten mutation results in severe SHP- 1 deficiency and provides a critical tool for elucidating the mechanism of ..
- Forward Genetic Analysis of the Innate Immune Contribution to MCMV ResistanceBruce Beutler; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Mutagenic analysis of LPS responsesBruce Beutler; Fiscal Year: 2006..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
- TLR4 as an LPS sendor and susceptibility locusBruce Beutler; Fiscal Year: 2007..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
- REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNSPAUL MASSA; Fiscal Year: 2007..We believe that information gained under these specific aims will elucidate mechanisms whereby SHP-1 controls virus infections in oligodendrocytes and perhaps other cells of the CNS. ..
- Deficiency of SHP-1 expression and function in multiple sclerosisPaul T Massa; Fiscal Year: 2010..abstract_text> ..