Genomes and Genes
Gene Symbol: PTG
Description: protein phosphatase 1, regulatory (inhibitor) subunit 3C
Alias: PTG, Ppp1r5, protein phosphatase 1 regulatory subunit 3C, PP1 subunit R5, ppp1r3c, protein phosphatase 1 binding protein PTG, protein phosphatase 1 regulatory subunit 5, protein phosphatase 1, regulatory (inhibitor) subunit 5, protein targeting to glicogen, protein targeting to glycogen
- PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolismJ A Printen
Department of Physiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Science 275:1475-8. 1997..A PP1C-targeting protein expressed in 3T3-L1 adipocytes (called PTG, for protein targeting to glycogen) was cloned and characterized. PTG was expressed predominantly in insulin-sensitive tissues...
- PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistanceSean M Crosson
Department of Medicine, Life Sciences Institute, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0650, USA
J Clin Invest 111:1423-32. 2003b>Protein targeting to glycogen (PTG) is a scaffolding protein that targets protein phosphatase 1alpha (PP1alpha) to glycogen, and links it to enzymes involved in glycogen synthesis and degradation...
- Central role for protein targeting to glycogen in the maintenance of cellular glycogen stores in 3T3-L1 adipocytesCynthia C Greenberg
Department of Medicine, University of Chicago, MC1027, 5841 S Maryland Ave, Chicago, IL 60637 1470, USA
Mol Cell Biol 26:334-42. 2006Overexpression of the protein phosphatase 1 (PP1) subunit protein targeting to glycogen (PTG) markedly enhances cellular glycogen levels...
- Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsyDavid Vilchez
Institute for Research in Biomedicine and University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, E 08028 Barcelona, Spain
Nat Neurosci 10:1407-13. 2007..The laforin-malin complex caused proteasome-dependent degradation both of the adaptor protein targeting to glycogen, PTG, which brings protein phosphatase 1 to MGS for activation, and of MGS itself...
- Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesisXiaolin Luo
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
Diabetes 60:1435-45. 2011..This study determines the molecular mechanism underlying the coupling of hepatic glycogenesis with the fasting-feeding cycle...
- PTG protein depletion rescues malin-deficient Lafora disease in mouseJulie Turnbull
Program in Genetics and Genome Biology, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 75:442-6. 2014..We show that reducing glycogen production in malin-deficient mice by genetically removing PTG, a glycogen synthesis activator protein, nearly completely eliminates Lafora bodies and rescues the ..
- Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesityBinbin Lu
Life Sciences Institute, University of Michigan, Ann Arbor, MI
Diabetes 63:2935-48. 2014..a high-fat diet (HFD) increases hepatic glycogen due to increased expression of the glycogenic scaffolding protein PTG/R5...
- Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogenR M O'Doherty
Gifford Laboratories for Diabetes Research, Marjorie Touchstone Diabetes Center, Department of Biochemistry, Dallas, Texas, USA
J Clin Invest 105:479-88. 2000Glycogen-targeting subunits of protein phosphatase-1, such as protein targeting to glycogen (PTG), direct the phosphatase to the glycogen particle, where it stimulates glycogenesis...
- Protein targeting to glycogen overexpression results in the specific enhancement of glycogen storage in 3T3-L1 adipocytesCynthia C Greenberg
Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
J Biol Chem 278:30835-42. 2003Protein phosphatase-1 (PP1) plays an important role in the regulation of glycogen synthesis by insulin. Protein targeting to glycogen (PTG) enhances glycogen accumulation by increasing PP1 activity against glycogen-metabolizing enzymes...
- Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cellsAlan Cheng
Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, 48109, USA
Endocrinology 147:3606-12. 2006The scaffolding protein, protein targeting to glycogen (PTG), orchestrates the signaling of several metabolic enzymes involved in glycogen synthesis. However, little is known concerning the regulation of PTG itself...
- Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liverDaniel Cifuentes
Institute for Research in Biomedicine, Universitat de Barcelona, Barcelona, Catalonia 08028, Spain
J Biol Chem 283:5642-9. 2008..be triggered through elevated expression of HKI or either of the protein phosphatase 1 regulatory subunits, namely PTG or G L...
- PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora diseaseJulie Turnbull
Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
PLoS Genet 7:e1002037. 2011..Here we remove PTG, one of the proteins that target PP1 to glycogen, from mice with Lafora disease...