PTG

Summary

Gene Symbol: PTG
Description: protein phosphatase 1, regulatory (inhibitor) subunit 3C
Alias: PTG, Ppp1r5, protein phosphatase 1 regulatory subunit 3C, PP1 subunit R5, ppp1r3c, protein phosphatase 1 binding protein PTG, protein phosphatase 1 regulatory subunit 5, protein phosphatase 1, regulatory (inhibitor) subunit 5, protein targeting to glicogen, protein targeting to glycogen
Species: mouse

Top Publications

  1. ncbi PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism
    J A Printen
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Science 275:1475-8. 1997
  2. pmc PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
    Sean M Crosson
    Department of Medicine, Life Sciences Institute, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0650, USA
    J Clin Invest 111:1423-32. 2003
  3. pmc Central role for protein targeting to glycogen in the maintenance of cellular glycogen stores in 3T3-L1 adipocytes
    Cynthia C Greenberg
    Department of Medicine, University of Chicago, MC1027, 5841 S Maryland Ave, Chicago, IL 60637 1470, USA
    Mol Cell Biol 26:334-42. 2006
  4. ncbi Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
    David Vilchez
    Institute for Research in Biomedicine and University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Nat Neurosci 10:1407-13. 2007
  5. pmc Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis
    Xiaolin Luo
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 60:1435-45. 2011
  6. doi PTG protein depletion rescues malin-deficient Lafora disease in mouse
    Julie Turnbull
    Program in Genetics and Genome Biology, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 75:442-6. 2014
  7. pmc Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity
    Binbin Lu
    Life Sciences Institute, University of Michigan, Ann Arbor, MI
    Diabetes 63:2935-48. 2014
  8. pmc Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen
    R M O'Doherty
    Gifford Laboratories for Diabetes Research, Marjorie Touchstone Diabetes Center, Department of Biochemistry, Dallas, Texas, USA
    J Clin Invest 105:479-88. 2000
  9. ncbi Protein targeting to glycogen overexpression results in the specific enhancement of glycogen storage in 3T3-L1 adipocytes
    Cynthia C Greenberg
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:30835-42. 2003
  10. ncbi Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells
    Alan Cheng
    Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, 48109, USA
    Endocrinology 147:3606-12. 2006

Detail Information

Publications12

  1. ncbi PTG, a protein phosphatase 1-binding protein with a role in glycogen metabolism
    J A Printen
    Department of Physiology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Science 275:1475-8. 1997
    ..A PP1C-targeting protein expressed in 3T3-L1 adipocytes (called PTG, for protein targeting to glycogen) was cloned and characterized. PTG was expressed predominantly in insulin-sensitive tissues...
  2. pmc PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance
    Sean M Crosson
    Department of Medicine, Life Sciences Institute, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0650, USA
    J Clin Invest 111:1423-32. 2003
    b>Protein targeting to glycogen (PTG) is a scaffolding protein that targets protein phosphatase 1alpha (PP1alpha) to glycogen, and links it to enzymes involved in glycogen synthesis and degradation...
  3. pmc Central role for protein targeting to glycogen in the maintenance of cellular glycogen stores in 3T3-L1 adipocytes
    Cynthia C Greenberg
    Department of Medicine, University of Chicago, MC1027, 5841 S Maryland Ave, Chicago, IL 60637 1470, USA
    Mol Cell Biol 26:334-42. 2006
    Overexpression of the protein phosphatase 1 (PP1) subunit protein targeting to glycogen (PTG) markedly enhances cellular glycogen levels...
  4. ncbi Mechanism suppressing glycogen synthesis in neurons and its demise in progressive myoclonus epilepsy
    David Vilchez
    Institute for Research in Biomedicine and University of Barcelona, Barcelona Science Park, Josep Samitier 1 5, E 08028 Barcelona, Spain
    Nat Neurosci 10:1407-13. 2007
    ..The laforin-malin complex caused proteasome-dependent degradation both of the adaptor protein targeting to glycogen, PTG, which brings protein phosphatase 1 to MGS for activation, and of MGS itself...
  5. pmc Fasting-induced protein phosphatase 1 regulatory subunit contributes to postprandial blood glucose homeostasis via regulation of hepatic glycogenesis
    Xiaolin Luo
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China
    Diabetes 60:1435-45. 2011
    ..This study determines the molecular mechanism underlying the coupling of hepatic glycogenesis with the fasting-feeding cycle...
  6. doi PTG protein depletion rescues malin-deficient Lafora disease in mouse
    Julie Turnbull
    Program in Genetics and Genome Biology, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 75:442-6. 2014
    ..We show that reducing glycogen production in malin-deficient mice by genetically removing PTG, a glycogen synthesis activator protein, nearly completely eliminates Lafora bodies and rescues the ..
  7. pmc Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity
    Binbin Lu
    Life Sciences Institute, University of Michigan, Ann Arbor, MI
    Diabetes 63:2935-48. 2014
    ..a high-fat diet (HFD) increases hepatic glycogen due to increased expression of the glycogenic scaffolding protein PTG/R5...
  8. pmc Activation of direct and indirect pathways of glycogen synthesis by hepatic overexpression of protein targeting to glycogen
    R M O'Doherty
    Gifford Laboratories for Diabetes Research, Marjorie Touchstone Diabetes Center, Department of Biochemistry, Dallas, Texas, USA
    J Clin Invest 105:479-88. 2000
    Glycogen-targeting subunits of protein phosphatase-1, such as protein targeting to glycogen (PTG), direct the phosphatase to the glycogen particle, where it stimulates glycogenesis...
  9. ncbi Protein targeting to glycogen overexpression results in the specific enhancement of glycogen storage in 3T3-L1 adipocytes
    Cynthia C Greenberg
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 278:30835-42. 2003
    Protein phosphatase-1 (PP1) plays an important role in the regulation of glycogen synthesis by insulin. Protein targeting to glycogen (PTG) enhances glycogen accumulation by increasing PP1 activity against glycogen-metabolizing enzymes...
  10. ncbi Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells
    Alan Cheng
    Department of Internal Medicine, Life Sciences Institute, University of Michigan, Ann Arbor, 48109, USA
    Endocrinology 147:3606-12. 2006
    The scaffolding protein, protein targeting to glycogen (PTG), orchestrates the signaling of several metabolic enzymes involved in glycogen synthesis. However, little is known concerning the regulation of PTG itself...
  11. doi Hepatic glycogen synthesis in the absence of glucokinase: the case of embryonic liver
    Daniel Cifuentes
    Institute for Research in Biomedicine, Universitat de Barcelona, Barcelona, Catalonia 08028, Spain
    J Biol Chem 283:5642-9. 2008
    ..be triggered through elevated expression of HKI or either of the protein phosphatase 1 regulatory subunits, namely PTG or G L...
  12. pmc PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease
    Julie Turnbull
    Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada
    PLoS Genet 7:e1002037. 2011
    ..Here we remove PTG, one of the proteins that target PP1 to glycogen, from mice with Lafora disease...