Pten

Summary

Gene Symbol: Pten
Description: phosphatase and tensin homolog
Alias: 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, MMAC1, PTENbeta, TEP1, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, mitochondrial PTENalpha, mutated in multiple advanced cancers 1
Species: mouse

Top Publications

  1. pmc Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    Zhenbang Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 436:725-30. 2005
  2. ncbi Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    P A Steck
    Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 15:356-62. 1997
  3. ncbi Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    Omer H Yilmaz
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 441:475-82. 2006
  4. ncbi Pten is essential for embryonic development and tumour suppression
    A Di Cristofano
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, NY 10021, USA
    Nat Genet 19:348-55. 1998
  5. pmc mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
    David A Guertin
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cancer Cell 15:148-59. 2009
  6. pmc Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
    K Podsypanina
    Departments of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P and S 14 453, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 96:1563-8. 1999
  7. ncbi High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
    A Suzuki
    Amgen Institute Ontario Cancer Institute Department of Medical Biophysics and Immunology University of Toronto Toronto, Ontario, Canada M5G 2C1
    Curr Biol 8:1169-78. 1998
  8. ncbi T cell-specific loss of Pten leads to defects in central and peripheral tolerance
    A Suzuki
    Department of Molecular and Cellular Biology, Osaka University, 565 0871, Osaka, Japan
    Immunity 14:523-34. 2001
  9. pmc The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice
    Mei Ling Chen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 20:1569-74. 2006
  10. pmc An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
    K Podsypanina
    Institute of Cancer Genetics, Department of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, Russ Berrie Pavilion, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:10320-5. 2001

Research Grants

  1. Role of Integrins in Pulmonary Fibrosis
    Eric White; Fiscal Year: 2006
  2. Androgen Receptor in Prostate Cancer and Bone
    Chawnshang Chang; Fiscal Year: 2005
  3. Bone matrix proteins in prostate cancer progression
    Pradip Roy Burman; Fiscal Year: 2010
  4. Androgen Receptor in B Cell Development and Functions
    Chawnshang Chang; Fiscal Year: 2010
  5. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
  6. Suppression of Androgen Receptor by PTEN
    Chawnshang Chang; Fiscal Year: 2006
  7. Single and Double Knockout of TR2 and TR4 Receptors
    Chawnshang Chang; Fiscal Year: 2006
  8. AR-ASSOCIATED PROTEINS IN PROSTATE CARCINOGENESIS
    Chawnshang Chang; Fiscal Year: 2001
  9. Induction of AR Transactivation by DHT and E2
    Chawnshang Chang; Fiscal Year: 2004
  10. TR4 ORPHAN RECEPTOR IN TESTIS
    Chawnshang Chang; Fiscal Year: 2004

Detail Information

Publications197 found, 100 shown here

  1. pmc Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    Zhenbang Chen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 436:725-30. 2005
    ..The PTEN and p53 tumour suppressors are among the most commonly inactivated or mutated genes in human cancer including ..
  2. ncbi Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    P A Steck
    Department of Neuro Oncology, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 15:356-62. 1997
    ..We have identified a gene, designated MMAC1, that spans these deletions and encodes a widely expressed 5.5-kb mRNA...
  3. ncbi Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    Omer H Yilmaz
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 441:475-82. 2006
    ..Here we address this issue by conditionally deleting the Pten tumour suppressor gene in adult haematopoietic cells...
  4. ncbi Pten is essential for embryonic development and tumour suppression
    A Di Cristofano
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, NY 10021, USA
    Nat Genet 19:348-55. 1998
    The PTEN gene encodes a dual-specificity phosphatase mutated in a variety of human cancers...
  5. pmc mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
    David A Guertin
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cancer Cell 15:148-59. 2009
    ..Here, we show that transformed human prostate epithelial cells lacking PTEN require mTORC2 to form tumors when injected into nude mice...
  6. pmc Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
    K Podsypanina
    Departments of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 630 W 168th Street, P and S 14 453, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 96:1563-8. 1999
    Pten/Mmac1+/- heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus...
  7. ncbi High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
    A Suzuki
    Amgen Institute Ontario Cancer Institute Department of Medical Biophysics and Immunology University of Toronto Toronto, Ontario, Canada M5G 2C1
    Curr Biol 8:1169-78. 1998
    Germ-line and sporadic mutations in the tumor suppressor gene PTEN (also known as MMAC or TEP1), which encodes a dual-specificity phosphatase, cause a variety of cancers such as Cowden disease, glioblastoma, endometrial carcinoma and ..
  8. ncbi T cell-specific loss of Pten leads to defects in central and peripheral tolerance
    A Suzuki
    Department of Molecular and Cellular Biology, Osaka University, 565 0871, Osaka, Japan
    Immunity 14:523-34. 2001
    b>PTEN, a tumor suppressor gene, is essential for embryogenesis. We used the Cre-loxP system to generate a T cell-specific deletion of the Pten gene (Pten(flox/-) mice). All Pten(flox/-) mice develop CD4+ T cell lymphomas by 17 weeks...
  9. pmc The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice
    Mei Ling Chen
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    Genes Dev 20:1569-74. 2006
    The tumor suppressor PTEN is frequently inactivated in human cancers. A major downstream effector of PTEN is Akt, which is hyperactivated via PTEN inactivation...
  10. pmc An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
    K Podsypanina
    Institute of Cancer Genetics, Department of Pathology and Medicine, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, Russ Berrie Pavilion, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 98:10320-5. 2001
    b>PTEN phosphatase acts as a tumor suppressor by negatively regulating the phosphoinositide 3-kinase (PI3K) signaling pathway. It is unclear which downstream components of this pathway are necessary for oncogenic transformation...
  11. pmc Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
    Changchun Xiao
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 9:405-14. 2008
    ..The miR-17-92 miRNA suppressed expression of the tumor suppressor PTEN and the proapoptotic protein Bim...
  12. pmc Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model
    David J Mulholland
    Departments of Molecular and Medical Pharmacology, University of California at Los Angeles, Los Angeles, California 90095 1735, USA
    Cancer Res 69:8555-62. 2009
    We have shown previously that Pten deletion leads to the expansion of subset of prostate cancer cells positive for CK5 and p63...
  13. pmc p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation
    Hongwu Zheng
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 455:1129-33. 2008
    ..The primary GBM subtype presents acutely as a high-grade disease that typically harbours mutations in EGFR, PTEN and INK4A/ARF (also known as CDKN2A), and the secondary GBM subtype evolves from the slow progression of a low-..
  14. pmc Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]
    Bangyan Stiles
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:2082-7. 2004
    ..Here, we investigated the function of phosphatase and tension homologue deleted on chromosome 10 (PTEN), a negative regulator of the phosphatidylinositol 3-kinase/AKT pathway, by targeted deletion of Pten in murine ..
  15. pmc PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
    H Sun
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 96:6199-204. 1999
    To investigate the molecular basis of PTEN-mediated tumor suppression, we introduced a null mutation into the mouse Pten gene by homologous recombination in embryonic stem (ES) cells...
  16. ncbi PTENless means more
    Bangyan Stiles
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, CHS23 234, Los Angeles, CA 90095, USA
    Dev Biol 273:175-84. 2004
    ..b>PTEN, a tumor suppressor that antagonizes the PI3 kinase pathway, is the newest one on the list...
  17. pmc Inactivation of p53 and Pten promotes invasive bladder cancer
    Anna M Puzio-Kuter
    Department of Urology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genes Dev 23:675-80. 2009
    ..We show that combined deletion of p53 and Pten in bladder epithelium leads to invasive cancer in a novel mouse model...
  18. ncbi High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice
    V Stambolic
    Amgen Research Institute and Ontario Cancer Institute, Toronto, Canada
    Cancer Res 60:3605-11. 2000
    b>PTEN is one of the most commonly mutated tumor suppressor genes in human cancer...
  19. ncbi PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum
    Silvia Marino
    Institute of Pathology, University Hospital, 8091 Zurich, Switzerland
    Development 129:3513-22. 2002
    b>PTEN is a tumour suppressor gene involved in cell cycle control, apoptosis and mediation of adhesion and migration signalling. Germline mutations of PTEN in humans are associated with familial tumour syndromes, among them Cowden disease...
  20. ncbi Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    S A Backman
    Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada
    Nat Genet 29:396-403. 2001
    Initially identified in high-grade gliomas, mutations in the PTEN tumor-suppressor are also found in many sporadic cancers and a few related autosomal dominant hamartoma syndromes...
  21. pmc Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    Yasuo Horie
    Department of Gastroenterology, Akita University School of Medicine, Akita, Japan
    J Clin Invest 113:1774-83. 2004
    b>PTEN is a tumor suppressor gene mutated in many human cancers, and its expression is reduced or absent in almost half of hepatoma patients...
  22. pmc Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
    Kevin Kyungsuk Park
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 322:963-6. 2008
    ..Deletion of PTEN (phosphatase and tensin homolog), a negative regulator of the mammalian target of rapamycin (mTOR) pathway, in ..
  23. pmc Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium
    Sanaz Memarzadeh
    Department of Obstetrics and Gynecology, The David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:17298-303. 2010
    ..In the majority of these tumors, PTEN expression is lost in the epithelium but maintained in tumor stroma...
  24. pmc Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes
    Takiko Daikoku
    Division of Reproductive Sciences, The Perinatal Institute, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Gynecol Oncol 122:424-9. 2011
    ..Our objective was to determine whether deletion of Pten specifically in the uterine stroma and myometrium induces cancer or manifests different phenotypes.
  25. pmc Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype
    Liang Lei
    Department of Pathology and Cell Biology, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e20041. 2011
    ..In addition, it is unclear how different genetic alterations interact with cells of origin in determining tumor heterogeneity. This issue cannot be addressed by studying end-stage human tumors...
  26. pmc Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
    B Kwabi-Addo
    Department of Pathology and Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:11563-8. 2001
    The PTEN gene encodes a lipid phosphatase that negatively regulates the phosphatidylinositol 3-kinase pathway and is inactivated in a wide variety of malignant neoplasms. High rates of loss of heterozygosity are observed at the 10q23...
  27. pmc Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis
    Minjung J Kim
    Center for Advanced Biotechnology and Medicine and Department of Neuroscience, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 99:2884-9. 2002
    ..Loss of function of Nkx3.1 in mice cooperates with loss of function of the Pten tumor suppressor gene in cancer progression...
  28. ncbi Genetic interactions between Pten and p53 in radiation-induced lymphoma development
    Jian Hua Mao
    Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, CA 94143, USA
    Oncogene 22:8379-85. 2003
    ..3 Mb interval that contained the Pten tumor suppressor gene...
  29. doi Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination
    Laurent Cotter
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule ETH Zurich, CH 8093 Zurich, Switzerland
    Science 328:1415-8. 2010
    ..Here, we show that, in Schwann cells, mammalian disks large homolog 1 (Dlg1) interacts with PTEN (phosphatase and tensin homolog deleted on chromosome 10) to inhibit axonal stimulation of myelination...
  30. pmc Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice
    Xiaohe Liu
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 120:2497-507. 2010
    Mutations in the tumor-suppressor gene phosphatase and tensin homolog deleted on chromosome 10 (Pten) are associated with multiple cancers in humans, including T cell malignancies...
  31. pmc Recruited cells can become transformed and overtake PDGF-induced murine gliomas in vivo during tumor progression
    Elena I Fomchenko
    Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 6:e20605. 2011
    ..Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. Yet, gliomas are cellularly heterogeneous; they recruit and trap normal cells during infiltration.
  32. pmc β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation
    I Ahmad
    The Beatson Institute for Cancer Research, Glasgow, Scotland, UK
    Oncogene 30:178-89. 2011
    ..These lesions were characterized by a marked increase of the phosphatase and tensin homologue (PTEN) tumour suppressor protein...
  33. pmc Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain
    Lionel M L Chow
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Cell 19:305-16. 2011
    Mutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of human glioblastomas...
  34. ncbi Impaired Fas response and autoimmunity in Pten+/- mice
    A Di Cristofano
    Department of Human Genetics Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Science 285:2122-5. 1999
    Inactivating mutations in the PTEN tumor suppressor gene, encoding a phosphatase, occur in three related human autosomal dominant disorders characterized by tumor susceptibility...
  35. ncbi Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice
    Jose R Bayascas
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Curr Biol 15:1839-46. 2005
    ..The importance of this pathway in tumorigenesis has been highlighted by the finding that PTEN, the lipid phosphatase that breaks down PtdIns(3,4,5)P(3) to PtdIns(4,5)P(2), is frequently mutated in human cancer...
  36. ncbi Essential role for nuclear PTEN in maintaining chromosomal integrity
    Wen Hong Shen
    Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cell 128:157-70. 2007
    A broad spectrum of mutations in PTEN, encoding a lipid phosphatase that inactivates the P13-K/AKT pathway, is found associated with primary tumors...
  37. pmc Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities
    M M Fraser
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Neuroscience 151:476-88. 2008
    ..The tumor-suppressor phosphatase with tensin homology (PTEN) is the central negative regulator of the PI3K pathway...
  38. doi Portrait of PTEN: messages from mutant mice
    Akira Suzuki
    Division of Embryonic and Genetic Engineering, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 99:209-13. 2008
    b>PTEN is a tumor suppressor gene mutated in many human sporadic cancers and in hereditary cancer syndromes such as Cowden disease...
  39. pmc Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
    Wei Guo
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nature 453:529-33. 2008
    ..Here we show that Pten deletion in mouse haematopoietic stem cells leads to a myeloproliferative disorder, followed by acute T-..
  40. pmc PTEN dosage is essential for neurofibroma development and malignant transformation
    Caroline Gregorian
    Department of Molecular and Medical Pharmacology, Institute for Molecular Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 106:19479-84. 2009
    ..In a series of genetically engineered murine models, we perturbed RAS/RAF/MAPK or/and PTEN/PI3K/AKT pathway, individually or simultaneously, via conditional activation of K-ras oncogene or deletion of Nf1 ..
  41. ncbi Somatic induction of Pten loss in a preclinical astrocytoma model reveals major roles in disease progression and avenues for target discovery and validation
    Andrew Xiao
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cancer Res 65:5172-80. 2005
    High-grade astrocytomas are invariably deadly and minimally responsive to therapy. Pten is frequently mutated in aggressive astrocytoma but not in low-grade astrocytoma. However, the Pten astrocytoma suppression mechanisms are unknown...
  42. pmc PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry
    Matthias Groszer
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:111-6. 2006
    ..Our previous study suggests that the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) tumor suppressor gene, one of the most frequently mutated genes in glioblastomas, restricts neural stem/progenitor ..
  43. pmc Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
    Stephanie A Backman
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute and University Health Network, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Proc Natl Acad Sci U S A 101:1725-30. 2004
    b>PTEN is a tumor suppressor gene mutated in various advanced human neoplasias, including glioblastomas and prostate, breast, endometrial, and kidney cancers...
  44. ncbi Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN
    Min Zhao
    School of Medical Sciences and Department of Ophthalmology, University of Aberdeen, Aberdeen AB25 2ZD, UK
    Nature 442:457-60. 2006
    ..Deletion of the tumour suppressor phosphatase and tensin homolog (PTEN) enhances signalling and electrotactic responses...
  45. pmc Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
    Brett S Carver
    Cancer Biology and Genetics Program, Sloan Kettering Institute, New York, New York, USA
    Nat Genet 41:619-24. 2009
    ..specimens containing the TMPRSS2-ERG rearrangement are significantly enriched for loss of the tumor suppressor PTEN. In concordance with these findings, transgenic overexpression of ERG in mouse prostate tissue promotes marked ..
  46. pmc A luminal epithelial stem cell that is a cell of origin for prostate cancer
    Xi Wang
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 461:495-500. 2009
    ..Furthermore, targeted deletion of the Pten tumour suppressor gene in CARNs results in rapid carcinoma formation after androgen-mediated regeneration...
  47. pmc Pten in stromal fibroblasts suppresses mammary epithelial tumours
    ANTHONY J TRIMBOLI
    Department of Molecular Genetics, College of Biological Sciences, The Ohio State University, Columbus, Ohio 43210, USA
    Nature 461:1084-91. 2009
    ..Here we show that the genetic inactivation of Pten in stromal fibroblasts of mouse mammary glands accelerated the initiation, progression and malignant transformation ..
  48. ncbi Insulin-like growth factor-II regulates PTEN expression in the mammary gland
    Roger A Moorehead
    Ontario Cancer Institute University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    J Biol Chem 278:50422-7. 2003
    The tumor suppressor PTEN is altered in many cancers, including breast cancer, but only a handful of factors are known to control its expression...
  49. doi Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Pathol 217:597-604. 2009
    ..Here we describe adrenal tumours generated in a Pten conditional knock-out (KO) mouse model...
  50. pmc Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells
    Michael Monet
    Department of Pharmacology, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 287:17672-81. 2012
    ..In this study we showed phosphoinositide 3-kinase and its antagonistic phosphatase, PTEN, are involved in the activation of TRPC6...
  51. pmc PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors
    Vincent W Keng
    Masonic Cancer Center, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 72:3405-13. 2012
    ..However, the phosphatase and tensin homolog (Pten) and neurofibromatosis 1 (Nf1) genes recently were found to be comutated in high-grade peripheral nerve sheath ..
  52. ncbi Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo
    Melissa M Fraser
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 64:7773-9. 2004
    Somatic mutations of PTEN are found in many types of cancers including glioblastoma, the most malignant astrocytic tumor. PTEN mutation occurs in 25 to 40% of glioblastomas but is rarely observed in low-grade glial neoplasms...
  53. pmc Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
    Leona Plum
    Department of Mouse Genetics and Metabolism, Institute for Genetics, University of Cologne and Center of Molecular Medicine Cologne CMMC, Cologne, Germany
    J Clin Invest 116:1886-901. 2006
    ..signals in hypothalamic proopiomelanocortin (POMC) neurons by inactivating the gene for the PIP3 phosphatase Pten specifically in this cell type...
  54. pmc Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis
    Alexandre Boyer
    Centre de Recherche en Reproduction Animale, Universite de Montreal, St Hyacinthe, Quebec J2S7C6, Canada
    Carcinogenesis 30:869-78. 2009
    ..if concomitant dysregulation of the WNT/CTNNB1 and PI3K/AKT pathways could synergize to cause testicular cancer, Pten(tm1Hwu/tm1Hwu);Ctnnb1(tm1Mmt/+);Amhr2(tm3(cre)Bhr/+) mice that express a dominant, stable CTNNB1 mutant and lack ..
  55. pmc A limited role for PI(3,4,5)P3 regulation in controlling skeletal muscle mass in response to resistance exercise
    D Lee Hamilton
    Division of Molecular Physiology, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 5:e11624. 2010
    ....
  56. pmc Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism
    Xinyu Wu
    Department of Urology, New York University School of Medicine, 423 East 23rd Street, New York, NY 10010, USA
    Dev Biol 356:337-49. 2011
    ..We found that gain of Notch function resulted in inhibition of the tumor suppressor PTEN, and increase in cell proliferation and progenitor cells in the basal epithelium and smooth muscle compartments...
  57. ncbi Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression
    Yvonne Lindsay
    Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 119:5160-8. 2006
    ..A similar distribution of PtdIns(3,4,5)P3 was observed in U87MG cells, which lack the PtdIns(3,4,5)P3 phosphatase, PTEN. Re-expression of PTEN into U87MG cells ablated plasma membrane PtdIns(3,4,5)P3, but not the nuclear pool of this ..
  58. pmc Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
    Shidong Jia
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 454:776-9. 2008
    ..Most strikingly, in an animal model of prostate tumour formation induced by Pten loss, ablation of p110beta (also known as Pik3cb), but not that of p110alpha (also known as Pik3ca), impeded ..
  59. pmc eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
    Luc Furic
    Goodman Cancer Centre and Department of Biochemistry, Cancer Pavilion, McGill University, Montreal, QC, Canada H3A 1A3
    Proc Natl Acad Sci U S A 107:14134-9. 2010
    ..Our findings establish eIF4E phosphorylation as a critical event in tumorigenesis. These findings raise the possibility that chemical compounds that prevent the phosphorylation of eIF4E could act as anticancer drugs...
  60. ncbi T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus
    T J Hagenbeek
    Department of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Leukemia 22:608-19. 2008
    Phosphatase and tensin homolog deleted on chromosome 10 (Pten) is a tumor suppressor protein whose loss of lipid phosphatase activity is associated with lymphomagenesis...
  61. doi Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
    Xu Huang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 412:211-21. 2008
    ..the importance of the LKB1-AMPK pathway in regulating tumorigenesis in mice resulting from deficiency of the PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour suppressor, which drives cell growth through ..
  62. ncbi Correlation between synaptogenesis and the PTEN phosphatase expression in dendrites during postnatal brain development
    Claudia Perandones
    Fundacion Instituto Leloir, IIBBA CONICET, IIB FCEN UBA, Avenue Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Brain Res Mol Brain Res 128:8-19. 2004
    The PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor gene codifies a lipid inositol 3'-phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase (PIP3-kinase)--..
  63. pmc Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells
    Heng Yu Fan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 69:6463-72. 2009
    ..Conversely, levels of PTEN and phosphorylated p38 mitogen-activated protein kinase (MAPK) increased markedly in the mutant granulosa cells...
  64. pmc The critical role of AKT2 in hepatic steatosis induced by PTEN loss
    Lina He
    Department of Molecular Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA
    Am J Pathol 176:2302-8. 2010
    ..Deletion of the phosphatase Pten (phosphatase and tensin homologue deleted on chromosome 10) reduces PIP3 levels and leads to fatty liver ..
  65. doi Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma
    Cassandra R Diegel
    Laboratory of Cell Signaling and Carcinogenesis, Van Andel Research Institute, Grand Rapids, Michigan 49504, USA
    Cancer Res 70:9143-52. 2010
    ..a mouse model in which both pathways are constitutively activated by the conditional inactivation of the Apc and Pten tumor suppressor genes. Loss of either Apc or Pten alone did not cause tumor development...
  66. pmc Ubiquitination regulates PTEN nuclear import and tumor suppression
    Lloyd C Trotman
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell 128:141-56. 2007
    The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden syndrome...
  67. pmc Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
    Shigehisa Yanagi
    Department of Molecular Biology, Akita University School of Medicine, Akita, Japan
    J Clin Invest 117:2929-40. 2007
    b>PTEN is a tumor suppressor gene mutated in many human cancers...
  68. doi Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
    Victoria Marsh
    Cardiff School of Biosciences, Cardiff University, UK
    Nat Genet 40:1436-44. 2008
    b>PTEN acts as a tumor suppressor in a range of tissue types and has been implicated in the regulation of intestinal stem cells...
  69. ncbi PTEN: a tumour suppressor that functions as a phospholipid phosphatase
    T Maehama
    Dept of Biological Chemistry, University of Michigan, USA
    Trends Cell Biol 9:125-8. 1999
    The tumour suppressor PTEN has been implicated in a large number of human tumours and is conserved from humans to worms...
  70. ncbi Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation
    Akira Suzuki
    Department of Biochemistry, Akita University School of Medicine, Akita 010 8543, Japan
    Cancer Res 63:674-81. 2003
    b>PTEN is a tumor suppressor gene mutated in many human cancers. We used the Cre-loxP system to generate a keratinocyte-specific null mutation of Pten in mice (k5Pten(flox/flox) mice)...
  71. pmc Pten dose dictates cancer progression in the prostate
    Lloyd C Trotman
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
    PLoS Biol 1:E59. 2003
    Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs at presentation...
  72. pmc The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling
    Thijs J Hagenbeek
    Department of Immunology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Exp Med 200:883-94. 2004
    The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) negatively regulates cell survival and proliferation mediated by phosphoinositol 3 kinases...
  73. pmc Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue
    Christine Kurlawalla-Martinez
    Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Mol Cell Biol 25:2498-510. 2005
    ..Phosphatase and a tensin homolog deleted from chromosome 10 (PTEN), a negative regulator of the phosphatidylinositol 3-kinase/AKT pathway, is hypothesized to inhibit the metabolic ..
  74. ncbi Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis
    Xiaoqian Ma
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, Netherlands
    Cancer Res 65:5730-9. 2005
    The PTEN tumor suppressor gene is frequently inactivated in human tumors, including prostate cancer. Based on the Cre/loxP system, we generated a novel mouse prostate cancer model by targeted inactivation of the Pten gene...
  75. pmc The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
    Koichi Hamada
    Department of Molecular Biology, Department of Microbiology, Department of Gastroenterology, Akita University School of Medicine, Akita 010 8543, Japan
    Genes Dev 19:2054-65. 2005
    b>PTEN is an important tumor suppressor gene. Hereditary mutation of PTEN causes tumor-susceptibility diseases such as Cowden disease...
  76. pmc Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
    Shunyou Wang
    Departments of Molecular and Medical Pharmacology and Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine, University of California Los Angeles, 650 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:1480-5. 2006
    b>PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a potent tumor suppressor gene frequently mutated in human prostate cancers...
  77. pmc Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes
    Bangyan L Stiles
    Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA
    Mol Cell Biol 26:2772-81. 2006
    Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a lipid phosphatase...
  78. pmc Pten regulates neuronal arborization and social interaction in mice
    Chang Hyuk Kwon
    Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 50:377-88. 2006
    CNS deletion of Pten in the mouse has revealed its roles in controlling cell size and number, thus providing compelling etiology for macrocephaly and Lhermitte-Duclos disease...
  79. pmc A novel leptin signalling pathway via PTEN inhibition in hypothalamic cell lines and pancreatic beta-cells
    Ke Ning
    Neurosciences Institute, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    EMBO J 25:2377-87. 2006
    ..of both hormones require intracellular signalling via the PI3-kinase pathway, which is inhibited by the phosphatase PTEN. We show that leptin-stimulated F-actin depolymerization in mouse hypothalamic cells is inhibited by PTEN, a ..
  80. pmc Lifelong accumulation of bone in mice lacking Pten in osteoblasts
    Ximeng Liu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 104:2259-64. 2007
    ..This process is negatively regulated by the Pten phosphatase, which inhibits the activity of PI3K...
  81. doi Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool
    Pradeep Reddy
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Science 319:611-3. 2008
    ..We provide genetic evidence that in mice lacking PTEN (phosphatase and tensin homolog deleted on chromosome 10) in oocytes, a major negative regulator of ..
  82. pmc Txnip balances metabolic and growth signaling via PTEN disulfide reduction
    Simon T Y Hui
    Department of Biology, The Molecular Biology and Heart Institutes, The BioSciences Center, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA
    Proc Natl Acad Sci U S A 105:3921-6. 2008
    ..and hearts was associated with impaired mitochondrial fuel oxidation and the accumulation of oxidized (inactive) PTEN, whose activity depends on reduction of two critical cysteine residues...
  83. pmc Pten haploinsufficiency accelerates formation of high-grade astrocytomas
    Chang Hyuk Kwon
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Cancer Res 68:3286-94. 2008
    ..achieve high grade, they are frequently accompanied by Akt activation, reminiscent of the frequent association of PTEN mutations in human high-grade glioma...
  84. doi PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells
    Anna Radziszewska
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    J Biol Chem 284:2917-22. 2009
    Phosphatase and tensin homologue (PTEN) deleted on chromosome 10 is a dual-specific phosphatase and a potent antagonist of the phosphoinositide 3-kinase signaling pathway...
  85. pmc Interactions between cells with distinct mutations in c-MYC and Pten in prostate cancer
    Jongchan Kim
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA
    PLoS Genet 5:e1000542. 2009
    ..Focal c-MYC expression resulted in mild pathology, but prostate-specific deletion of a single allele of the Pten tumor suppressor gene cooperated with c-MYC to induce high grade prostatic intraepithelial neoplasia (HGPIN)/cancer ..
  86. ncbi Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    V Stambolic
    Amgen Institute, and Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Cell 95:29-39. 1998
    b>PTEN is a tumor suppressor with sequence homology to protein tyrosine phosphatases and the cytoskeletal protein tensin. mPTEN-mutant mouse embryos display regions of increased proliferation...
  87. ncbi Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse
    A Di Cristofano
    Department of Human Genetics, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
    Nat Genet 27:222-4. 2001
    The genetic bases underlying prostate tumorigenesis are poorly understood. Inactivation of the tumor-suppressor gene PTEN and lack of p27(KIP1) expression have been detected in most advanced prostate cancers...
  88. ncbi Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease
    C H Kwon
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, Tennessee 38105, USA
    Nat Genet 29:404-11. 2001
    Somatic inactivation of PTEN occurs in different human tumors including glioblastoma, endometrial carcinoma and prostate carcinoma...
  89. ncbi Cre/loxP-mediated inactivation of the murine Pten tumor suppressor gene
    Ralf Lesche
    Howard Hughes Medical Institute and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Genesis 32:148-9. 2002
  90. pmc Protean PTEN: form and function
    Kristin A Waite
    Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, 420 West 12th Avenue, Columbus, OH 43210, USA
    Am J Hum Genet 70:829-44. 2002
    Germline mutations distributed across the PTEN tumor-suppressor gene have been found to result in a wide spectrum of phenotypic features...
  91. pmc DNA mismatch repair deficiency accelerates endometrial tumorigenesis in Pten heterozygous mice
    Hong Wang
    Department of Pathology, Weill Medical Collegeof Cornell University, New York
    Am J Pathol 160:1481-6. 2002
    b>PTEN mutation and microsatellite instability are two of the most common genetic alterations in uterine endometrioid carcinoma...
  92. ncbi Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
    Michael A Crackower
    IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, c o Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Cell 110:737-49. 2002
    The PTEN/PI3K signaling pathway regulates a vast array of fundamental cellular responses...
  93. ncbi PTEN regulation of neural development and CNS stem cells
    Li Li
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biochem 88:24-8. 2003
    ..Such a phosphatase, phosphatase and tensin homologue deleted on chromosome 10 (PTEN), was cloned as a tumor suppressor for gliomas...
  94. pmc Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination
    Akira Suzuki
    Department of Molecular Cell Biology, Research Institute for Microbial Disease, Osaka University, Osaka 565 0871, Japan
    J Exp Med 197:657-67. 2003
    b>Pten is a tumor suppressor gene mutated in human cancers. We used the Cre-loxP system to generate a B cell-specific mutation of Pten in mice (bPten(flox/flox)mice)...
  95. ncbi Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
    Tohru Kimura
    Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Development 130:1691-700. 2003
    The tumor suppressor gene PTEN, which is frequently mutated in human cancers, encodes a lipid phosphatase for phosphatidylinositol 3,4,5-triphosphate [PtdIns(3,4,5)P3] and antagonizes phosphatidylinositol 3 kinase...
  96. ncbi Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastases
    Cory Abate-Shen
    Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry, New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Cancer Res 63:3886-90. 2003
    ..Here, we have investigated the malignant potential of the high-grade PIN lesions that form in Nkx3.1(+/-); Pten(+/-) compound mutant mice and demonstrate their neoplastic progression in a serial transplantation/tissue ..
  97. ncbi Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    Shunyou Wang
    Howard Hughes Medical Institute, University of California Los Angeles School of Medicine, 90095, Los Angeles, CA, USA
    Cancer Cell 4:209-21. 2003
    The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive ..
  98. pmc grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice
    Megan Cully
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Princess Margaret Hospital, 610 University Avenue, Room 7 411, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 101:15358-63. 2004
    b>PTEN is a tumor suppressor gene implicated in both sporadic cancers and inherited tumor-prone syndromes. Here we show that pten+/- mice display a partially penetrant embryonic lethality...
  99. ncbi PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization
    Qing Yue
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA
    Development 132:3281-91. 2005
    ..We provide evidence that loss of PTEN in Bergmann glia leads to premature differentiation of this crucial cell population and subsequently to extensive ..
  100. ncbi Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner
    Lina I Yoo
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 66:1929-39. 2006
    b>PTEN deficiency predisposes to a subset of human cancers, but the mechanism that underlies such selectivity is unknown. We have generated a mouse line that conditionally deletes Pten in urogenital epithelium...
  101. ncbi Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis
    Chen Zhong
    Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Cancer Res 66:2188-94. 2006
    ..overexpression of a mitogenic polypeptide (fibroblast growth factor 8, isoform b or FGF8b) and loss of function of PTEN tumor suppressor] were recapitulated into a new combinatorial mouse model...

Research Grants21

  1. Role of Integrins in Pulmonary Fibrosis
    Eric White; Fiscal Year: 2006
    ..basement membrane invasive activity of fibrotic-lung fibroblasts results from a deficiency in intracellular PTEN activity...
  2. Androgen Receptor in Prostate Cancer and Bone
    Chawnshang Chang; Fiscal Year: 2005
    ..The success of this proposal will allow a better understanding of the role of androgen in the metastatic spread of prostate cancer to bone and the molecular mechanism of bone remodeling by prostate cancer cells. ..
  3. Bone matrix proteins in prostate cancer progression
    Pradip Roy Burman; Fiscal Year: 2010
    ..abstract_text> ..
  4. Androgen Receptor in B Cell Development and Functions
    Chawnshang Chang; Fiscal Year: 2010
    ..abstract_text> ..
  5. Role of Acetaldehyde in Alcoholic Cardiomyopathy
    Jun Ren; Fiscal Year: 2008
    ..Our long-term goal is to establish the toxic mechanism of acetaldehyde in the development of alcoholic cardiomyopathy so that prevention and treatment can be optimized [unreadable] [unreadable]..
  6. Suppression of Androgen Receptor by PTEN
    Chawnshang Chang; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): PTEN and AR are highly involved in the prostate cancer progression. The linkage between these two antagonistic factors remains unclear...
  7. Single and Double Knockout of TR2 and TR4 Receptors
    Chawnshang Chang; Fiscal Year: 2006
    ..In summary, this proposal provides us the first opportunity to study the potential in vivo physiological roles of the TR2 and TR4 orphan nuclear receptors. ..
  8. AR-ASSOCIATED PROTEINS IN PROSTATE CARCINOGENESIS
    Chawnshang Chang; Fiscal Year: 2001
    ..As a result, ultimately, we might find a potential protocol to manage the progression of CaP in the clinic. ..
  9. Induction of AR Transactivation by DHT and E2
    Chawnshang Chang; Fiscal Year: 2004
    ....
  10. TR4 ORPHAN RECEPTOR IN TESTIS
    Chawnshang Chang; Fiscal Year: 2004
    ..Aim 5) Study cross talk between p53 and TR4 in testes. The successful completion of this proposal may help us to better understand the molecular mechanism of the TR4 and its potential biochemical functions. ..
  11. IGF-1, Oxidative Stress and Cardiovascular Aging
    Jun Ren; Fiscal Year: 2002
    ..Our long-term goal is to establish the causal link among IGF-1 deficiency, enhanced oxidative damage and ventricular dysfunction in the progression of cardiovascular aging so that hormonal or antioxidant therapy can be optimized...
  12. TR2 AND TR3 ORPHAN RECEPTORS IN PROSTATE CANCER
    Chawnshang Chang; Fiscal Year: 2002
    ..abstract_text> ..
  13. Validation of potential early diagnostic and prognostic markers for pancreatic ca
    Paul Chiao; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  14. Mechanisms of Tumorigenesis in Pancreatic Epithelial Cells
    Paul Chiao; Fiscal Year: 2009
    ..abstract_text> ..
  15. THE ROLE OF RE1A IN HUMAN ADENOCARCINOMA OF PANCREAS
    Paul Chiao; Fiscal Year: 2002
    ..The studies may lead to the development of specific inhibitors of Rel/NFkB for use in novel therapies for pancreatic cancers. ..
  16. Fatty Acid Effects on COX-2 Dependent Prostate Cancer
    Russell Klein; Fiscal Year: 2005
    ..abstract_text> ..
  17. PGE2 Regulation of Epithelial/Fibroblast Interactions
    Bethany Moore; Fiscal Year: 2006
    ..abstract_text> ..
  18. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  19. CXC CHEMOKINE REGULATION OF PROSTATE CANCER ANGIOGENESIS
    Bethany Moore; Fiscal Year: 2002
    ..These studies should lead to new insights into the biology of prostate cancer growth and metastasis, and pave the way to adapt adjuvant therapies for the treatment of this widespread disease. ..