Ptafr

Summary

Gene Symbol: Ptafr
Description: platelet-activating factor receptor
Alias: PAFR, platelet-activating factor receptor, PAF receptor
Species: mouse

Top Publications

  1. ncbi Ontogeny of expression of a receptor for platelet-activating factor in mouse preimplantation embryos and the effects of fertilization and culture in vitro on its expression
    T Stojanov
    Human Reproduction Unit, Department of Physiology, University of Sydney, Royal North Shore Hospital of Sydney, St Leonards, New South Wales 2065, Australia
    Biol Reprod 60:674-82. 1999
  2. ncbi Efficient chromosomal mapping of a methylcholanthrene-induced tumor antigen by CTL immunoselection
    S Akilesh
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 167:5143-9. 2001
  3. pmc Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression
    Jeffrey P Walterscheid
    Department of Immunology, The University of Texas, M D Anderson Cancer Center, and The Graduate School of Biomedical Sciences, Houston, Texas 77030 4009, USA
    J Exp Med 195:171-9. 2002
  4. ncbi Platelet-activating factor receptor-deficient mice show an unaltered clearance of nontypeable Haemophilus influenzae from their respiratory tract
    Judith Branger
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Shock 22:543-7. 2004
  5. pmc Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor
    Yasuyuki Kihara
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    J Exp Med 202:853-63. 2005
  6. ncbi Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology
    Sophie Fillon
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 177:6182-91. 2006
  7. ncbi Improved host defense against pneumococcal pneumonia in platelet-activating factor receptor-deficient mice
    Anita W Rijneveld
    Laboratory of Experimental Internal Medicine and Department of Internal Medicine, Academic Medical Center, University of Amsterdam, F4 105, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 189:711-6. 2004
  8. pmc Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy
    Hisako Hikiji
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo, Japan
    J Clin Invest 114:85-93. 2004
  9. ncbi Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 290:L194-9. 2006
  10. ncbi Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage
    Gopal K Marathe
    Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City 84112 5330, USA
    J Biol Chem 280:35448-57. 2005

Research Grants

  1. Keratinocyte-derived immuno-suppressive cytokines
    Stephen Ullrich; Fiscal Year: 2005
  2. Do NKT cells mediate UV induced Immune Suppression?
    Stephen Ullrich; Fiscal Year: 2005
  3. Inflammatory mediators and UV-induced carcinogenesis
    Stephen Ullrich; Fiscal Year: 2009
  4. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
  5. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
  6. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
  7. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
  8. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications83

  1. ncbi Ontogeny of expression of a receptor for platelet-activating factor in mouse preimplantation embryos and the effects of fertilization and culture in vitro on its expression
    T Stojanov
    Human Reproduction Unit, Department of Physiology, University of Sydney, Royal North Shore Hospital of Sydney, St Leonards, New South Wales 2065, Australia
    Biol Reprod 60:674-82. 1999
    ..Transcripts for the G protein-linked PAF receptor were detected in the late 2-cell-stage embryo and in all stages from the 4-cell stage to blastocysts...
  2. ncbi Efficient chromosomal mapping of a methylcholanthrene-induced tumor antigen by CTL immunoselection
    S Akilesh
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 167:5143-9. 2001
    ..1 cM interval on chromosome 4. This region of the mouse genome is rich in tumor-modifier genes and this positioning of Ram1 may thus provide insight into the genetic basis of 3-methycholanthrene-induced tumor Ags...
  3. pmc Platelet-activating factor, a molecular sensor for cellular damage, activates systemic immune suppression
    Jeffrey P Walterscheid
    Department of Immunology, The University of Texas, M D Anderson Cancer Center, and The Graduate School of Biomedical Sciences, Houston, Texas 77030 4009, USA
    J Exp Med 195:171-9. 2002
    ..Furthermore, immune suppression was blocked when UV-irradiated mice were injected with PAF receptor antagonists...
  4. ncbi Platelet-activating factor receptor-deficient mice show an unaltered clearance of nontypeable Haemophilus influenzae from their respiratory tract
    Judith Branger
    Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands
    Shock 22:543-7. 2004
    ..a glycerophospholipid with proinflammatory properties, exerts its biological effects by interacting with the PAF receptor (PAFR) expressed on many different cell types...
  5. pmc Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor
    Yasuyuki Kihara
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    J Exp Med 202:853-63. 2005
    ..To investigate the role of platelet-activating factor (PAF) in this disease, PAF receptor (PAFR) KO (PAFR-KO) and wild-type (WT) mice, on a C57BL/6 genetic background, were immunized with myelin ..
  6. ncbi Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology
    Sophie Fillon
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    J Immunol 177:6182-91. 2006
    ..We describe an additional recognition system mediated by the platelet-activating factor receptor (PAFr) and directed to the pathogen-associated molecular pattern phosphorylcholine that results in the uptake of ..
  7. ncbi Improved host defense against pneumococcal pneumonia in platelet-activating factor receptor-deficient mice
    Anita W Rijneveld
    Laboratory of Experimental Internal Medicine and Department of Internal Medicine, Academic Medical Center, University of Amsterdam, F4 105, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Infect Dis 189:711-6. 2004
    ..factor (PAF) is a phospholipid with proinflammatory properties that binds to a specific receptor (PAF receptor [PAFR]) that is expressed on many different cell types...
  8. pmc Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy
    Hisako Hikiji
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo, Japan
    J Clin Invest 114:85-93. 2004
    ..Using PAF receptor-deficient mice, we evaluated the role of PAF in the development of bone resorption following ovariectomy, a ..
  9. ncbi Involvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumonia
    Koenraad F Van Der Sluijs
    Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 290:L194-9. 2006
    ..Considering that S. pneumoniae utilizes the platelet-activating factor receptor (PAFR) to invade the respiratory epithelium and that the PAFR is upregulated during viral infection, we here used PAFR ..
  10. ncbi Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage
    Gopal K Marathe
    Human Molecular Biology and Genetics Program, University of Utah, Salt Lake City 84112 5330, USA
    J Biol Chem 280:35448-57. 2005
    ..Expression of the PAF receptor in the PAF receptor-negative epidermoid cell line KB augmented apoptosis in response to UVB irradiation...
  11. pmc Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor
    Qiwei Zhang
    Department of Dermatology, H B Wells Center for Pedoatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Clin Invest 115:2855-61. 2005
    ..These findings show a novel mechanism by which staphylococcal infections can inhibit Th1 reactions and thus worsen Th2 skin diseases, such as atopic dermatitis...
  12. pmc beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae
    Jana N Radin
    Department of Infectious Diseases, St Jude Children s Research Hospital, Mailstop 320 IRC 8057, 332 N Lauderdale Rd, Memphis, TN 38105, USA
    Infect Immun 73:7827-35. 2005
    ..The platelet-activating factor receptor (PAFr) has been suggested as a portal of entry...
  13. pmc Lipoteichoic acid-induced nitric oxide production depends on the activation of platelet-activating factor receptor and Jak2
    Seung Hyun Han
    Department of Pathology, University of Alabama at Birmingham, AL 35294, USA
    J Immunol 176:573-9. 2006
    ..Inhibitors of platelet-activating factor receptor (PAFR) blocked LTA- or Pam3CSK4-induced production of NO but not TNF-alpha...
  14. pmc Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium
    Peter Tyrer
    School of Health Sciences, University of Canberra, Canberra, ACT 2601, Australia
    Infect Immun 74:625-31. 2006
    ..Taken together, the data suggest that pathogen-associated molecular pattern interactions with pattern recognition receptors are key factors in M-cell recognition of intestinal antigens for mucosal immune priming...
  15. pmc Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice
    Kent Doi
    Department of Nephrology and Endocrinology, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
    Am J Pathol 168:1413-24. 2006
    ..In this study we used platelet-activating factor receptor (PAFR)-deficient mice to elucidate the role of PAF in inflammatory renal injury induced by folic acid administration...
  16. pmc Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor
    S Ishii
    Department of Biochemistry, Faculty of Medicine, The University of Tokyo, Japan
    EMBO J 16:133-42. 1997
    ..To answer this question, we established transgenic mice over-expressing a guinea-pig PAF receptor (PAFR)...
  17. pmc The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza
    Jonathan A McCullers
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105 2794, USA
    Scand J Infect Dis 40:11-7. 2008
    ..advanced the hypothesis that interactions of pneumococcus with the receptor for platelet activating factor (PAFR) in the lung were facilitated by antecedent influenza virus infection and play a major role in the pathogenesis of ..
  18. pmc UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system
    Qiwei Zhang
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Invest Dermatol 128:1780-7. 2008
    ..These studies suggest that UVB irradiation results in epidermal production of PAF agonists, which then act on PAF-R-positive bone marrow-derived cells to upregulate IL-10 through COX-2-generated prostaglandins...
  19. pmc Inhibition of photocarcinogenesis by platelet-activating factor or serotonin receptor antagonists
    Coimbatore S Sreevidya
    Department of Immunology and the Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Cancer Res 68:3978-84. 2008
    ....
  20. pmc Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species
    Yongxue Yao
    Department of Dermatology, and the Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 182:2842-8. 2009
    ..These studies suggest that UVB-induced systemic immunosuppression is due to epidermal growth factor receptor-mediated ROS which results in PAF-R agonist formation...
  21. pmc Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection
    Danielle G Souza
    Immunopharmacology, Departmento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG 31270 901, Brazil
    Proc Natl Acad Sci U S A 106:14138-43. 2009
    ..Treatment is supportive. Activation of platelet-activating factor (PAF) receptor (PAFR) on endothelial cells and leukocytes induces increase in vascular permeability, hypotension, and production of ..
  22. pmc Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor
    Kimberly D Dyer
    Section of Eosinophil Biology, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1883, USA
    J Immunol 184:6327-34. 2010
    ..promote degranulation (release of eosinophil peroxidase) via a mechanism that is independent of the characterized PAFR. Specifically, we demonstrate that receptor antagonists CV-3988 and WEB-2086 and pertussis toxin have no impact on ..
  23. pmc Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis
    Ravi P Sahu
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Carcinogenesis 33:694-701. 2012
    ..This suggests that the platelet activating factor receptor (PAFR) acts to suppress chronic inflammation in response to other stimuli, such as barrier ..
  24. pmc The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists
    Ravi P Sahu
    Department of Dermatology, Indiana University School of Medicine, 1044 Walnut St Rm 202, Indianapolis, IN 46202, USA
    Carcinogenesis 33:1360-7. 2012
    ..in wild-type (WT) mice, independent of whether B16F10 cells express PAF-Rs, but do not augment tumor growth in Pafr -/- mice...
  25. pmc Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists
    Ravi P Sahu
    Department of Dermatology, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 190:2447-54. 2013
    ..These studies provide the first evidence, to our knowledge, that the pro-oxidative stressor CS can modulate cutaneous immunity via the generation of PAF-R agonists produced through lipid oxidation...
  26. pmc Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor
    S Ishii
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo 113, Japan
    J Exp Med 187:1779-88. 1998
    ..Here we show that disruption of the PAF receptor gene in mice caused a marked reduction in systemic anaphylactic symptoms...
  27. ncbi Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice
    S Ishii
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Prog Lipid Res 39:41-82. 2000
    ..PAF acts by binding to a unique G-protein-coupled seven transmembrane receptor. PAF receptor is linked to intracellular signal transduction pathways, including turnover of phosphatidylinositol, elevation ..
  28. ncbi Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor
    Makoto Tsuda
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    J Neurochem 102:1658-68. 2007
    ..the role of platelet-activating factor (PAF), a phospholipid mediator, in pain signaling using mice lacking PAF receptor (pafr-/- mice)...
  29. pmc Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment
    Danielle G Souza
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    Br J Pharmacol 139:733-40. 2003
    ..The present study aimed to confirm a role for platelet-activating factor receptor(s) (PAFR) during ischemia and reperfusion injury by using genetically modified mice deficient in the PAFR (PAFR(-/-) mice) ..
  30. ncbi Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model
    Satoshi Ishii
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 172:7095-102. 2004
    ..We show in this study that mice deficient in PAF receptor exhibited significantly reduced airway hyperresponsiveness to muscarinic cholinergic stimulation in an asthma ..
  31. pmc A murine platelet-activating factor receptor gene: cloning, chromosomal localization and up-regulation of expression by lipopolysaccharide in peritoneal resident macrophages
    S Ishii
    Department of Biochemistry, Faculty of Medicine, The University of Tokyo, Japan
    Biochem J 314:671-8. 1996
    A murine gene encoding a platelet-activating factor receptor (PAFR) was cloned. The gene was mapped to a region of the D2.2 band of chromosome 4 both by fluorescence in situ hybridization and by molecular linkage analysis...
  32. doi Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet
    Marina Chaves de Oliveira
    Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    J Nutr Biochem 26:978-85. 2015
    ..Wild-type (WT) and PAF receptor-deficient (PAFR(-/-)) mice were fed the same diets for 8 weeks...
  33. pmc Expression of PAFR as part of a prosurvival response to chemotherapy: a novel target for combination therapy in melanoma
    Ana Claudia Onuchic
    Departamento de Radiologia e Oncologia, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de Sao Paulo, 01246 903 Sao Paulo, SP, Brazil
    Mediators Inflamm 2012:175408. 2012
    Melanoma cells express the platelet-activating factor receptor (PAFR) and, thus, respond to PAF, a bioactive lipid produced by both tumour cells and those in the tumour microenvironment such as macrophages...
  34. doi Platelet-activating factor receptor knockout mice are protected from MPTP-induced dopaminergic degeneration
    Beom Keun Kim
    Department of Pharmacology, College of Medicine, Chung Ang University, Seoul 156 756, Republic of Korea
    Neurochem Int 63:121-32. 2013
    ..We propose for the first time that PAF/PAF-R can mediate dopaminergic degeneration via an NF-κB-dependent signaling process. ..
  35. pmc Platelet-activating factor receptor blockade ameliorates Aggregatibacter actinomycetemcomitans-induced periodontal disease in mice
    Mila Fernandes Moreira Madeira
    Department of Microbiology, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Infect Immun 81:4244-51. 2013
    ..actinomycetemcomitans in wild-type (WT) and PAF receptor knockout (Pafr(-/-)) mice. In vitro experiments using A...
  36. doi Activation of PAF-receptor induces regulatory dendritic cells through PGE2 and IL-10
    Marianna M Koga
    Departamento de Imunologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo 05508 900, SP, Brazil
    Prostaglandins Leukot Essent Fatty Acids 89:319-26. 2013
    Activation of the platelet-activating factor receptor (PAFR) in macrophages is associated with suppressor phenotype. Here, we investigated the PAFR in murine dendritic cells (DC)...
  37. doi Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis
    Matheus Corrêa-Costa
    Department of Immunology, Institute of Biomedical Sciences IV, University of Sao Paulo, Sao Paulo, Brazil
    Lab Invest 94:455-66. 2014
    ..In the present study, we investigated the role of PAF receptor (PAFR) in an experimental model of chronic renal disease...
  38. doi Central role of PAFR signalling in ExoU-induced NF-κB activation
    Carolina Diettrich Mallet de Lima
    Departamento de Microbiologia, Imunologia e Parasitologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Cell Microbiol 16:1244-54. 2014
    ..aeruginosa strains. Several approaches showed that PAFR was crucially implicated in the activation of the canonical NF-κB pathway...
  39. pmc Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor
    Ravi P Sahu
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana
    Cancer Res 74:7069-78. 2014
    ..Furthermore, they offer new insights into how to improve the efficacy of chemotherapy by blocking its heretofore unknown impact on PAF-R activation...
  40. pmc Topical application of a platelet activating factor receptor agonist suppresses phorbol ester-induced acute and chronic inflammation and has cancer chemopreventive activity in mouse skin
    Ravi P Sahu
    Departments of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, United States of America
    PLoS ONE 9:e111608. 2014
    ..PAF acts by binding to a specific G-protein coupled receptor (PAF-R, Ptafr). However, the role of chronic PAF-R activation on sustained inflammatory responses has been largely ignored...
  41. doi A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation
    Masahiko Yamaguchi
    Department of Pharmaco Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka City, Shizuoka 422 8526, Japan
    Biochem Pharmacol 93:482-95. 2015
    ..In the present study, we investigated whether PAF/PAF receptor signaling contributed to chronic inflammation in the white adipose tissue (WAT) of PAF receptor-knockout (PAFR-..
  42. pmc Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase
    Jinbo Liu
    Department of Cell Biology, NE10, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH 44195, USA
    Circ Res 108:469-77. 2011
    ....
  43. doi The role of platelet-activating factor receptor (PAFR) in lung pathology during experimental malaria
    Norinne Lacerda-Queiroz
    Laboratório de Imunofarmacologia Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, Minas Gerais, Brazil
    Int J Parasitol 43:11-5. 2013
    ..Using mice lacking the PAF receptor (PAFR(-/-)) we investigated the relevance of signaling through the PAFR for the lung inflammatory process ..
  44. doi Stimulation of Ly-6G on neutrophils in LPS-primed mice induces platelet-activating factor (PAF)-mediated anaphylaxis-like shock
    Yukinori Tanaka
    Department of Oral Biology, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai, Japan
    J Leukoc Biol 91:485-94. 2012
    ..These findings may be related to adult respiratory distress syndrome, although the natural ligand for Ly-6G remains to be identified...
  45. doi Platelet-activating factor receptor plays a role in the pathogenesis of graft-versus-host disease by regulating leukocyte recruitment, tissue injury, and lethality
    Marina G M Castor
    Laboratorio de Imunofarmacologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
    J Leukoc Biol 91:629-39. 2012
    ..The present study evaluated the relevance of PAFR for the pathogenesis of acute GVHD using a model of adoptive transfer of splenocytes from WT or PAFR(-/-) C57BL/6J ..
  46. pmc Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor
    André Luis Lacerda Bachi
    Microbiology, Immunology, and Parasitology Department, Federal University of Sao Paulo, 04023 900 São Paulo, SP, Brazil
    Mediators Inflamm 2012:610371. 2012
    There is evidence that the platelet-activating factor receptor (PAFR) is involved in the clearance of apoptotic cells by macrophages, and that this is associated with anti-inflammatory phenotype...
  47. doi Platelet-activating factor receptor is essential for the development of experimental cerebral malaria
    Norinne Lacerda-Queiroz
    Department of Cell Biology, Institute of Biological Sciences, Faculty of Medicine, Federal University of Minas Gerais, Minas Gerais, Brazil
    Am J Pathol 180:246-55. 2012
    ..Using mice lacking the PAF receptor (PAFR(-/-)), we investigated the relevance of this molecule for the outcome and the neuroinflammatory process ..
  48. pmc Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia
    Simon Keely
    Mucosal Inflammation Program, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Mol Biol Cell 21:538-46. 2010
    ..A screen of relevant pathway inhibitors identified a prominent role for the platelet-activating factor receptor (PAFr) in hypoxia-associated bacterial translocation, wherein pharmacologic antagonists of PAFr blocked bacterial ..
  49. doi Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons
    Scott D Ryan
    Neural Regeneration Laboratory and Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Canada
    J Lipid Res 49:2250-8. 2008
    ..We find that both C16-PAF and C18-PAF cause PAF receptor-independent death but signal through different pathways...
  50. pmc Role of PAF receptor in proinflammatory cytokine expression in the dorsal root ganglion and tactile allodynia in a rodent model of neuropathic pain
    Shigeo Hasegawa
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 5:e10467. 2010
    ..However, lipid mediators downstream of cPLA(2) activation to produce tactile allodynia remain to be determined...
  51. pmc Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy
    Soraya I de Oliveira
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    BMC Cancer 10:200. 2010
    ..These studies were performed in murine tumours: Ehrlich Ascitis Tumour (EAT) and B16F10 melanoma...
  52. pmc Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice
    Cristiana C Garcia
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    PLoS Pathog 6:e1001171. 2010
    ..Platelet activating factor (PAF) receptor (PAFR) deficient mice were used to evaluate the role of the gene in a model of experimental infection with Influenza A/..
  53. pmc Dendritic cells produce inflammatory cytokines in response to bacterial products from Staphylococcus aureus-infected atopic dermatitis lesions
    Timothy Voorhees
    Department of Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor, MI 48109, United States
    Cell Immunol 267:17-22. 2011
    ..Thus, our results support a role for DC in the worsening of AD inflammation due to secondary bacteria infections...
  54. doi Regulation of the expression of proto-oncogenes by autocrine embryotropins in the early mouse embryo
    Xing Liang Jin
    Centre for Developmental and Regenerative Medicine, Kolling Institute for Medical Research, Sydney Medical School, University of Sydney, New South Wales, Australia
    Biol Reprod 84:1216-24. 2011
    ..The results show that Paf induces periodic transient transcriptions of key proto-oncogenes that result in the persistent presence of the resulting proteins in the preimplantation phase of development...
  55. doi Absence of PAF receptor alters cellular infiltrate but not rolling and adhesion of leukocytes in experimental autoimmune encephalomyelitis
    David Henrique Rodrigues
    Laboratory of Immunopharmacology, Federal University of Minas Gerais, Belo Horizonte, Brazil
    Brain Res 1385:298-306. 2011
    ..Thus, in this study, we aimed to evaluate the role of PAF receptor in the pathogenesis of EAE. EAE was induced using an emulsion containing MOG(35-55)...
  56. ncbi Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo
    W E Roudebush
    Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston 29425, USA
    Biol Reprod 57:575-9. 1997
    ..PAF's signal transduction mechanism in other cell types is receptor mediated. However, embryonic mRNA for the PAF receptor has not been detected...
  57. ncbi Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages
    H Shinji
    Department of Microbiology II, The Jikei University School of Medicine, Tokyo, Japan
    J Immunol 158:1370-6. 1997
    ..The results also suggest that the later IP3 change is considered to be mediated through a gamma2 type of phosphatidylinositol-specific PLC...
  58. ncbi Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development
    D P Lu
    Human Reproduction Unit, Department of Physiology, University of Sydney, Royal North Shore Hospital, St Leonards, NSW 2065, Australia
    J Cell Sci 117:1567-76. 2004
    ..Ca(2+)](i) transient in two-cell embryos that did not occur in platelet-activating factor-receptor null (Pafr-/-) genotype embryos...
  59. ncbi Platelet-activating factor receptor-deficient mice are protected from experimental sleep apnea-induced learning deficits
    Barry W Row
    Kosair Children s Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, Kentucky 40202, USA
    J Neurochem 89:189-96. 2004
    ..We report that mice deficient in the cell surface receptor for PAF (PAFR-/-), a bioactive mediator of oxidative stress and inflammation, are protected from the spatial reference learning ..
  60. ncbi Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice
    Stephen R Reeves
    Department of Pediatrics, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Physiol Regul Integr Comp Physiol 287:R369-74. 2004
    During hypoxia, release of platelet-activating factor (PAF) and activation of its cognate receptor (PAFR) regulate neural transmission and are required for full expression of peak hypoxic ventilatory response (pHVR) but not hypercapnic ..
  61. ncbi Involvement of platelet-activating factor and LIS1 in neuronal migration
    Suzumi M Tokuoka
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, CREST of JST, Tokyo 113 0033, Japan
    Eur J Neurosci 18:563-70. 2003
    ..We have previously shown the expression of PAF receptor in neurons and microglia...
  62. ncbi Platelet-activating factor receptor and respiratory and metabolic responses to hypoxia and hypercapnia
    Stephen R Reeves
    Departments of Pediatrics and Pharmacology and Toxicology, Kosair Children s Hospital Research Institute, University of Louisville School of Medicine, Suite 204, 570 South Preston St, Louisville, KY 40202, USA
    Respir Physiol Neurobiol 141:13-20. 2004
    Activation of the platelet-activating factor receptor (PAFR) regulates neural transmission. A PAFR blocker reduced the peak hypoxic (pHVR) but not hypercapnic ventilatory (HCVR) responses in rats [Am. J. Physiol. 275 (1998) R604]...
  63. ncbi Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization
    Veronique Angeli
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Immunity 21:561-74. 2004
    ..In this context, HDL and PAFAH maintain a normally functional DC compartment...
  64. pmc Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase
    Hélène Hudry-Clergeon
    INSERM EMI 02 19, Laboratoire de Développement et Vieillissement de l Endothélium, Département Réponse Dynamique Cellulaire, Commissariat a l Energie Atomique, Grenoble Cedex 9, France
    FASEB J 19:512-20. 2005
    ..This study was designed to characterize PAF receptor (PAF-R) expression and its specific contribution to the modifications of adherens junctions in mouse ..
  65. ncbi Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice
    Andre Talvani
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, 6627 Pampulha, 31270 901 Belo Horizonte, Minas Gerais, Brazil
    Microbes Infect 5:789-96. 2003
    ..cruzi infection by using mice that were genetically deficient in the PAF receptor. We observed that infected hearts of PAFR(-/-) mice had an increased number of parasite nests, associated with ..
  66. ncbi Characterisation of the mouse diabetes susceptibilty locus Nidd/SJL: islet cell destruction, interaction with the obesity QTL Nob1, and effect of dietary fat
    L Plum
    Institute of Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, Aachen, Germany
    Diabetologia 45:823-30. 2002
    ..Here we characterise its effects in a NZO x F1(SJLxNZO) backcross population raised on high-fat or standard diet, and describe its interaction with the obesity quantitative trait locus (QTL) Nob1...
  67. ncbi A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis
    Takahide Nagase
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 8:480-4. 2002
    ..The inhibition of cPLA(2)-initiated pathways might provide a novel therapeutic approach to pulmonary fibrosis, for which no pharmaceutical agents are currently available...
  68. pmc Embryonic platelet-activating factor: temporal expression of the ligand and receptor
    William E Roudebush
    Reproductive Biology Associates, Atlanta, Georgia 30342, USA
    J Assist Reprod Genet 19:72-8. 2002
    ..The study objective was to determine the relationship between PAF production and PAF-receptor mRNA expression levels in mouse preimplantation embryos...
  69. ncbi Receptor-dependent metabolism of platelet-activating factor in murine macrophages
    Noriyasu Ohshima
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 0033 Japan
    J Biol Chem 277:9722-7. 2002
    Degradation of platelet-activating factor (PAF) was examined by incubating PAF with macrophages from PAF receptor-deficient mice. The degradation rate was halved as compared with wild-type mice...
  70. ncbi Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis
    Susana E Moreno
    Departamento de Farmacologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Sao Paulo, Brazil
    J Immunol 177:1264-71. 2006
    ..Using a PAFR antagonist, PCA-4248, and PAFR-deficient mice, we investigated whether signaling via PAFR was relevant for the ..
  71. pmc A role for inflammatory mediators in the induction of immunoregulatory B cells
    Yumi Matsumura
    Department of Immunology and Center for Cancer Immunology Research, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Immunol 177:4810-7. 2006
    ..When UV-irradiated mice were injected with PCA 4248, a selective PAF receptor (PAFR) antagonist, transfer of tolerance was suppressed...
  72. ncbi Evidence for the autocrine induction of capacitation of mammalian spermatozoa
    C Wu
    Human Reproduction Unit, Department of Physiology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    J Biol Chem 276:26962-8. 2001
    ..These actions were inhibited by a PAF receptor antagonist (UR-12519) and by extracellular recombinant PAF:acetylhydrolase (an enzyme that degrades PAF to a ..
  73. ncbi Hypersusceptibility to invasive pneumococcal infection in experimental sickle cell disease involves platelet-activating factor receptor
    Martha L Miller
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Infect Dis 195:581-4. 2007
    ..Platelet-activating factor receptor (PAFr) mediates pneumococcal invasion, and up-regulation of PAFr on chronically activated endothelia could contribute to ..
  74. ncbi Attenuated LTP in hippocampal dentate gyrus neurons of mice deficient in the PAF receptor
    C Chen
    Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurophysiol 85:384-90. 2001
    ..Long-term potentiation (LTP) can be induced by the application of PAF and blocked by a PAF receptor (PAF-R) inhibitor in the hippocampal CA1 and dentate gyrus...
  75. ncbi Augmentation of UVB radiation-mediated early gene expression by the epidermal platelet-activating factor receptor
    Jeffrey B Travers
    Department of Dermatology, H B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Invest Dermatol 128:455-60. 2008
    ..To gain a better insight into the role of the epidermal PAF receptor (PAF-R) in UVB-mediated gene expression, Affymetrix oligonucleotide microarrays were used to compare mRNA ..
  76. pmc Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response
    Atsushi Fukunaga
    Department of Immunology and Center for Cancer Immunology Research, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    J Immunol 180:3057-64. 2008
    ..In contrast, applying DNFB to PAF receptor-deficient mice or mice injected with PAF receptor antagonists failed to induce LC migration...
  77. ncbi Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response
    Marieke A D van Zoelen
    Center for Infection and Immunity Amsterdam, Department for Pathology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:3357-65. 2008
    ..Platelet-activating factor receptor (PAFR) is involved in phagocytosis of several pathogens. To determine the role of PAFR in the innate immune response to P...
  78. ncbi Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor
    Sylvia Knapp
    Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 180:3478-84. 2008
    ..In vitro data indicate roles for TLR2, platelet-activating factor receptor (PAFR), CD14, and LPS-binding protein (LBP) in cellular responsiveness to LTA, whereas the mechanisms contributing to LTA ..
  79. pmc A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation
    Peter J Leary
    Division of Critical Care Medicine, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA
    Am J Physiol Heart Circ Physiol 294:H2775-84. 2008
    ..To determine whether endogenous activation of the PAF receptor is cardioprotective, we examined postischemic functional recovery in isolated hearts from wild-type and PAF ..
  80. pmc Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice
    T Nagase
    Department of Geriatric Medicine, and Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo 113, Japan
    J Clin Invest 104:1071-6. 1999
    ..Here, we investigated the role of platelet-activating factor (PAF) and the PAF receptor (PAFR) gene in a murine model of acid aspiration-induced lung injury...
  81. pmc Platelet-activating factor receptor deficiency delays elimination of adult worms but reduces fecundity in Strongyloides venezuelensis-infected mice
    Deborah Negrao-Correa
    Departamento de Parasitologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Infect Immun 72:1135-42. 2004
    ..kinetics and histopathological and immunological alterations in platelet-activating factor receptor-deficient (PAFR(-/-)) and wild-type mice after a single Strongyloides venezuelensis infection (subcutaneous inoculation of 500 L3 ..
  82. pmc Involvement of platelet-activating factor in ultraviolet B-induced hyperalgesia
    Qiwei Zhang
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Invest Dermatol 129:167-74. 2009
    ..These substances exert effects through the PAF receptor (PAF-R). This study was designed to assess whether PAF-R is involved in UVB-induced hyperalgesia...
  83. ncbi Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region
    K Kobayashi
    Department of Neurophysiology, Faculty of Medicine, University of Tokyo, Japan
    Eur J Neurosci 11:1313-6. 1999
    ..We re-examined a possible contribution of PAF to LTP with a more specific approach using mice deficient in the PAF receptor. The PAF receptor-deficient mice exhibited normal LTP and showed no obvious abnormality in excitatory synaptic ..

Research Grants8

  1. Keratinocyte-derived immuno-suppressive cytokines
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved may help with the design of rational approaches to block the induction of immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  2. Do NKT cells mediate UV induced Immune Suppression?
    Stephen Ullrich; Fiscal Year: 2005
    ..A better understanding of the mechanisms involved in UV-induced immune suppression may help with the design of rational approaches to block immune suppression, thereby reducing one of the major risk factors for skin cancer induction. ..
  3. Inflammatory mediators and UV-induced carcinogenesis
    Stephen Ullrich; Fiscal Year: 2009
    ..close link between UV-induced carcinogenesis and UV-induced immune suppression, we propose that serotonin and PAF receptor antagonists would serve as ideal agents to block sunlight-induced skin cancer formation...
  4. Lethal synergism between influenza and pneumococcus
    Jonathan McCullers; Fiscal Year: 2003
    ....
  5. 2nd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2003
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  6. Influenza-pneumococcal synergism: role of neuraminidase
    Jonathan McCullers; Fiscal Year: 2004
    ....
  7. 3rd Orthomyxoviruses Research Conference
    Jonathan McCullers; Fiscal Year: 2005
    ..The purpose of this proposal is to provide funds that will allow promising young investigators to interact with their peers and develop a commitment to this area of research. ..
  8. Synergism Between Influenza Virus and Pneumococcus
    Jonathan McCullers; Fiscal Year: 2009
    ....