Prkdc

Summary

Gene Symbol: Prkdc
Description: protein kinase, DNA activated, catalytic polypeptide
Alias: AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip, DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, doxorubicin nephropathy, severe combined immunodeficiency
Species: mouse

Top Publications

  1. ncbi Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
    W Schuler
    Cell 46:963-72. 1986
  2. ncbi Lymphocytes mediate TNF-alpha-induced endothelial cell adhesion molecule expression: studies on SCID and RAG-1 mutant mice
    Y Horie
    Department of Molecular and Cellular Physiology, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    J Immunol 159:5053-62. 1997
  3. ncbi Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice
    S Babu
    Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA
    J Immunol 161:1428-32. 1998
  4. ncbi Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
    G E Taccioli
    Department of Microbiology, Boston University School of Medicine, Massachusetts 02118, USA
    Immunity 9:355-66. 1998
  5. pmc The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
    F A Goytisolo
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Madrid E 28049, Spain
    Mol Cell Biol 21:3642-51. 2001
  6. pmc Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    Nathalia Holt
    Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Nat Biotechnol 28:839-47. 2010
  7. pmc Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9
    Yuhui Wang
    Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell Metab 9:287-302. 2009
  8. pmc Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation
    Rita U Lukacs
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 90095, USA
    Cell Stem Cell 7:682-93. 2010
  9. pmc PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
    Taku Okazaki
    Division of Immune Regulation, Institute for Genome Research, University of Tokushima, Kuramoto, Tokushima, Japan
    J Exp Med 208:395-407. 2011
  10. pmc Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice
    Prabal Banerjee
    Department Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY, USA
    Blood 115:2640-8. 2010

Research Grants

  1. DNA REPAIR/V(D)J RECOMBINATION--FUNCTIONAL STUDY
    Guillermo Taccioli; Fiscal Year: 2001
  2. EXPERIMENTAL DIABETIC AUTONOMIC NEUROPATHY
    ROBERT EDWARD SCHMIDT; Fiscal Year: 2010
  3. Regulation of Recall Responses During Ehrlichiosis
    Gary M Winslow; Fiscal Year: 2010
  4. Hypocretin Neurons
    Anthony N van den Pol; Fiscal Year: 2010
  5. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2009
  6. 5th Comparative Medicine Resource Center Director Mtg.
    Stephen Barthold; Fiscal Year: 2008
  7. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2008
  8. KILLER CELLS AND ALCOHOL
    ZUHAIR BALLAS; Fiscal Year: 2008
  9. Immunodeficiency and Neuronal Function
    JOHN PETITTO; Fiscal Year: 2008
  10. Control of Dendritic Cell Generation and Function by Tumor
    Michael Shurin; Fiscal Year: 2008

Detail Information

Publications185 found, 100 shown here

  1. ncbi Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
    W Schuler
    Cell 46:963-72. 1986
    ..No such abnormal rearrangements were detected in transformed tissues from control mice. The scid mutation may adversely affect the recombinase system catalyzing the assembly of antigen receptor genes in ..
  2. ncbi Lymphocytes mediate TNF-alpha-induced endothelial cell adhesion molecule expression: studies on SCID and RAG-1 mutant mice
    Y Horie
    Department of Molecular and Cellular Physiology, Louisiana State University Medical Center, Shreveport 71130 3932, USA
    J Immunol 159:5053-62. 1997
    ..vascular beds (lung, heart, stomach, mesentery, small intestine, large intestine, and muscle) in wild-type and SCID mice...
  3. ncbi Host NK cells are required for the growth of the human filarial parasite Brugia malayi in mice
    S Babu
    Department of Pathology, University of Connecticut Health Center, Farmington 06030, USA
    J Immunol 161:1428-32. 1998
    ..survival and development in different strains of mice with varying levels of NK cell activity reveal that NOD/LtSz-scid/scid and NOD/LtSz-scid/scid B2m(null) mice (with diminished to absent NK cell activity respectively), are ..
  4. ncbi Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity
    G E Taccioli
    Department of Microbiology, Boston University School of Medicine, Massachusetts 02118, USA
    Immunity 9:355-66. 1998
    ..Although our DNA-PKcs defective mice closely resemble Scid mice, they differ by having elevated numbers of CD4+CD8+ thymocytes...
  5. pmc The absence of the dna-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang
    F A Goytisolo
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Madrid E 28049, Spain
    Mol Cell Biol 21:3642-51. 2001
    ..Here we show that, besides DNA repair, a role for DNA-PKcs is to protect telomeres, which in turn are essential for chromosomal stability...
  6. pmc Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
    Nathalia Holt
    Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Nat Biotechnol 28:839-47. 2010
    ..ZFN-treated HSPCs retained the ability to engraft NOD/SCID/IL2rgamma(null) mice and gave rise to polyclonal multi-lineage progeny in which CCR5 was permanently disrupted...
  7. pmc Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9
    Yuhui Wang
    Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell Metab 9:287-302. 2009
    ..Thus, Sox9 is a Pref-1 target, and Pref-1 directs multipotent mesenchymal cells to the chondrogenic lineage but inhibits differentiation into adipocytes as well as osteoblasts and chondrocytes...
  8. pmc Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation
    Rita U Lukacs
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 90095, USA
    Cell Stem Cell 7:682-93. 2010
    ..We conclude that Bmi-1 is a crucial regulator of self-renewal in adult prostate cells and plays important roles in prostate cancer initiation and progression...
  9. pmc PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
    Taku Okazaki
    Division of Immune Regulation, Institute for Genome Research, University of Tokushima, Kuramoto, Tokushima, Japan
    J Exp Med 208:395-407. 2011
    ..In addition, LAG-3 deficiency alone accelerated type 1 diabetes mellitus in nonobese diabetic mice. These results demonstrate that LAG-3 acts synergistically with PD-1 and/or other immunoregulatory genes to prevent autoimmunity in mice...
  10. pmc Adult T-cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice
    Prabal Banerjee
    Department Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY, USA
    Blood 115:2640-8. 2010
    ..HTLV-1-infected humanized nonobese diabetic severe combined immunodeficiency (HU-NOD/SCID) mice were generated by inoculation of NOD/SCID mice with CD34(+) hematopoietic ..
  11. doi IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction
    Clara Westwell-Roper
    Department of Pathology and Laboratory Medicine, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4
    J Immunol 187:2755-65. 2011
    ..islet dysfunction, islets from wild-type or hIAPP-expressing transgenic mice were transplanted into diabetic NOD/SCID recipients implanted with mini-osmotic pumps containing IL-1Ra (50 mg/kg/d) or saline...
  12. ncbi The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis
    Takashi Kagari
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    J Immunol 169:1459-66. 2002
    ..Because arthritis was also developed in SCID mice, the development of arthritis in the Ab-induced mice model is due to a mechanism that does not involve T or B ..
  13. pmc CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 184:7082-91. 2010
    Stable engraftment of human lymphoid tissue in NOD/scid-IL-2Rgammacnull mice after CD34+ hematopoietic stem cell reconstitution permits the evaluation of ongoing HIV-1 infection for weeks to months...
  14. pmc Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia
    Joanna Pancewicz
    Department of Pathology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Proc Natl Acad Sci U S A 107:16619-24. 2010
    ..These data suggest that activated Notch may be important to ATL pathogenesis and reveal Notch1 as a target for therapeutic intervention in ATL patients...
  15. ncbi High levels of human peripheral blood mononuclear cell engraftment and enhanced susceptibility to human immunodeficiency virus type 1 infection in NOD/LtSz-scid/scid mice
    R M Hesselton
    Department of Pediatrics, University of Massachusetts Medical School, Worcester, USA
    J Infect Dis 172:974-82. 1995
    Inbred C.B-17-scid/scid mice accept human peripheral blood mononuclear cell (PBMC) xenografts and are susceptible to human immunodeficiency virus type 1 (HIV-1) infection, but low levels of PBMC engraftment impede use of this system in ..
  16. pmc T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice
    Priti Kumar
    Immune Disease Institute and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Cell 134:577-86. 2008
    ..Moreover, scFvCD7-9R could deliver antiviral siRNAs to naive T cells in Hu-HSC mice and effectively suppress viremia in infected mice. Thus, siRNA therapy for HIV infection appears to be feasible in a preclinical animal model...
  17. pmc DNA-PKcs is critical for telomere capping
    D Gilley
    Department of Cellular and Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 98:15084-8. 2001
    ..it was reported that bone marrow cells and spontaneously transformed fibroblasts from SCID (severe combined immunodeficiency) mice have defects in telomere maintenance...
  18. ncbi Identification of a B-1 B cell-specified progenitor
    Encarnacion Montecino-Rodriguez
    Department of Pathology and Laboratory Medicine and the Hematopoietic Malignancies Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Nat Immunol 7:293-301. 2006
    ..These data indicate that the CD45R(lo-neg)CD19(+) population includes B-1 B cell-specified progenitors and support models proposing distinct developmental pathways for B-1 B cells...
  19. pmc Phosphorylation of p50 NF-kappaB at a single serine residue by DNA-dependent protein kinase is critical for VCAM-1 expression upon TNF treatment
    Jihang Ju
    Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 285:41152-60. 2010
    ..Together, these results elucidate a novel mechanism for the involvement of DNA-PK in the positive regulation of p50 NF-κB to drive VCAM-1 expression...
  20. pmc Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes
    Terri C Thayer
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Diabetes 60:2144-51. 2011
    ..We previously linked decreased monocyte ROS with diabetes resistance in the alloxan-resistant mouse, and NOD-Ncf1(m1J) mice with a genetic ablation of NOX activity had reduced and delayed type 1 diabetes compared with NOD mice...
  21. pmc Intestinal CX3C chemokine receptor 1(high) (CX3CR1(high)) myeloid cells prevent T-cell-dependent colitis
    Hisako Kayama
    Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, 565 0871, Japan
    Proc Natl Acad Sci U S A 109:5010-5. 2012
    ..Thus, these cells are regulatory myeloid cells that are responsible for maintaining intestinal homeostasis...
  22. pmc scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair
    K A Biedermann
    Department of Radiation Oncology, Stanford University Medical Center, CA 94305
    Proc Natl Acad Sci U S A 88:1394-7. 1991
    C.B-17 severe combined immunodeficient (scid) mice carry the scid mutation and are severely deficient in both T cell- and B cell-mediated immunity, apparently as a result of defective V(D)J joining of the immunoglobulin and T-cell ..
  23. ncbi DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect
    C U Kirchgessner
    Department of Radiation Oncology, Stanford University School of Medicine, CA 94305
    Science 267:1178-83. 1995
    Severe combined immunodeficient (SCID) mice are deficient in a recombination process utilized in both DNA double-strand break repair and in V(D)J recombination...
  24. ncbi Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice
    L D Shultz
    Jackson Laboratory, Bar Harbor, ME 04609
    J Immunol 154:180-91. 1995
    The scid mutation was backcrossed ten generations onto the NOD/Lt strain background, resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive as well as nonadaptive immunologic function...
  25. pmc TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice
    Reiko Horai
    Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Clin Invest 114:1603-11. 2004
    ..These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40...
  26. ncbi IFN beta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice
    Aurora Alba
    Laboratory of Immunobiology for Research and Diagnostic Applications, Transfusion Center and Tissue Bank, Germans Trias i Pujol University Hospital, Barcelona, Spain
    J Immunol 173:6667-75. 2004
    ..These results indicate that the antiviral cytokine IFNbeta breaks peripheral tolerance to beta cells, influences the insulitis progression and contributes to autoimmunity in diabetes and nondiabetes- prone mice...
  27. pmc Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation
    Mohammad B Hossain
    Department of Biochemistry and Molecular Biology, Genes and Development Program of the Graduate School of Biomedical Sciences, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 284:8621-32. 2009
    ..Transient transfection and chromatin immunoprecipitation experiments suggest that PARP-1 plays a role during transcriptional activation by NRF-1. Our finding identifies a new aspect of transcriptional regulation used by NRF-1...
  28. doi Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells
    Jun Kunisawa
    Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Blood 111:4646-52. 2008
    ..These findings suggest that NIK in stromal cells has a specific role in the regulation of S1P-mediated trafficking of peritoneal B cells...
  29. pmc Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes
    S M Lee
    Department of Pathology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60612, USA
    Diabetologia 54:1136-46. 2011
    ..Here we sought to determine the therapeutic potential of the sirtuin 1 activator resveratrol in the treatment of diabetes in the NOD mouse model of type 1 diabetes and the mechanisms underlying such potential...
  30. pmc Effects of high-fat diets rich in either omega-3 or omega-6 fatty acids on UVB-induced skin carcinogenesis in SKH-1 mice
    You Rong Lou
    Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 32:1078-84. 2011
    ..Our results indicate that omega-3 fatty acids in HFFO diet have beneficial effects against UVB-induced skin carcinogenesis, and these effects may be associated with an inhibition on UVB-induced inflammatory response...
  31. pmc Attenuated nephritis in inducible nitric oxide synthase knockout C57BL/6 mice and pulmonary hemorrhage in CB17 SCID and recombination activating gene 1 knockout C57BL/6 mice infected with Leptospira interrogans
    Mauricio Bandeira
    Federal University of Bahia, Salvador, Bahia, Brazil
    Infect Immun 79:2936-40. 2011
    ..The animals used were Inos KO mice, recombination activating gene 1 (Rag1) KO mice, CB17 severe combined immunodeficiency (SCID) mice, and the respective wild-type (WT) C57BL/6 and BALB/c controls...
  32. pmc Type 1 interferons suppress accelerated osteoclastogenesis and prevent loss of bone mass during systemic inflammatory responses to Pneumocystis lung infection
    Michelle Wilkison
    Department of Immunology and Infectious Diseases, Montana State University, Bozeman, MT, USA
    Am J Pathol 181:151-62. 2012
    ....
  33. ncbi Critical role of leukocyte function-associated antigen-1 in liver accumulation of CD4+NKT cells
    M Emoto
    Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
    J Immunol 162:5094-8. 1999
    ..These results demonstrate a crucial role for LFA-1 in the accumulation of CD4+NKT cells in the liver...
  34. doi Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model
    Yong Zhao
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochem Biophys Res Commun 399:629-36. 2010
    ..We develop this model in NOD-scid IL2rgamma(null) mice...
  35. ncbi Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice
    Sandra J Engle
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0524, USA
    Cancer Res 62:6362-6. 2002
    ..This animal model should provide insight into the protective role of TGF-beta1 in early stages of ulcerative colitis-associated human colon cancer...
  36. pmc Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes
    Elsa Callen
    Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Mol Cell 34:285-97. 2009
    ..Our experiments reveal a DNA-PKcs-dependent pathway that regulates DNA repair and activation of p53 in the absence of ATM...
  37. pmc Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells
    Alison Y Swaims
    Child Health Institute of New Jersey, University of Medicine and Dentistry of New Jersey UMDNJ, Robert Wood Johnson Medical School RWJMS, New Brunswick, NJ 08901, USA
    Blood 116:2994-3003. 2010
    ..Engraftment of activated LTR-Tax CD4(+) T cells into NOD/Shi-scid/IL-2Rγ null mice resulted in a leukemia-like phenotype with expansion and tissue infiltration of Tax(+), CD4(+) ..
  38. ncbi Delayed wound healing in immunodeficient TGF-beta 1 knockout mice
    M J Crowe
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Invest Dermatol 115:3-11. 2000
    ..disease is eliminated in transforming growth factor-beta1-deficient mice lacking T and B cells (Tgfb1-/- Scid-/- mice), we hypothesized that wound repair in the latter would proceed normally, even at later stages of healing...
  39. pmc Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells
    Xunrong Luo
    Division of Nephrology, Department of Medicine, and the Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 104:2821-6. 2007
    ..When cotransferred with diabetogenic cells into NOD scid recipients, T regs induced with DCs and TGF-beta1 prevent the development of diabetes...
  40. pmc Non-obese diabetic-recombination activating gene-1 (NOD-Rag1 null) interleukin (IL)-2 receptor common gamma chain (IL2r gamma null) null mice: a radioresistant model for human lymphohaematopoietic engraftment
    T Pearson
    Diabetes Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Clin Exp Immunol 154:270-84. 2008
    ..CB17-Prkdc(scid) (NOD-Prkdc(scid)) IL2rgamma(null) mice...
  41. doi PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome
    Yunru Li
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    J Pathol 224:90-100. 2011
    ..These findings could potentially lead to the discovery of novel therapeutic modalities for advanced PCA...
  42. ncbi Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice
    J Neyts
    Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium
    J Med Virol 41:242-6. 1993
    Severe combined immune deficient (SCID) mice inoculated intravenously with vaccinia virus (VV) became sick within 6-8 days and died 10-12 days after infection. Tail lesions developed and the number depended on the virus inoculum...
  43. ncbi p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes
    M A Bogue
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 10:553-65. 1996
    The murine scid mutation affects both V(D)J recombination and DNA repair...
  44. pmc Transfer of type II collagen-induced arthritis from DBA/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1
    P C Taylor
    Kennedy Institute of Rheumatology, London, UK
    Immunology 88:315-21. 1996
    ..01, chi 2). In the DBA/1 to severe combined immunodeficiency (SCID) transfer model of arthritis, the incidence of clinical arthritis was significantly reduced in ..
  45. pmc Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes
    J S Danska
    Division of Surgical Research, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    Mol Cell Biol 16:5507-17. 1996
    The scid gene product has been identified as the 460-kDa catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs p460), a member of the phosphatidylinositol 3-kinase family...
  46. ncbi IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells
    John P Manis
    Howard Hughes Medical Institute and Children s Hospital, Center for Blood Research and Department of Genetics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Immunity 16:607-17. 2002
    ..We conclude that DNA-PKcs is required for CSR to most C(H) genes but that CSR to gamma1 occurs via a DNA-PKcs-independent mechanism...
  47. pmc Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice
    Michele P Marron
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Proc Natl Acad Sci U S A 99:13753-8. 2002
    ..These findings provide the first functional evidence that certain human MHC class I molecules can contribute to the development of T1D...
  48. ncbi The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice
    Rebecca A Gladdy
    Program in Developmental Biology, The Hospital for Sick Children and Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Cancer Cell 3:37-50. 2003
    ..We show that RAG-1/2-induced DSB cause IgH/c-Myc translocations in leukemic pro-B cells from p53/Prkdc-deficient mice. Strikingly, these translocations were complex, clonally heterogeneous and amplified...
  49. ncbi Dysfunctional mammalian telomeres join with DNA double-strand breaks
    Susan M Bailey
    Department of Radiological Health Services, Colorado State University, Fort Collins, CO 80523 1618, USA
    DNA Repair (Amst) 3:349-57. 2004
    ..b>Severe combined immunodeficiency (scid) is caused by a mutation in the catalytic subunit of DNA-dependent protein kinase (DNA-PK), an ..
  50. ncbi Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice
    Scott J Banuelos
    Department of Surgery, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Clin Immunol 112:273-83. 2004
    ..Model one: human PBMCs were engrafted into chemically diabetic NOD-scid mice bearing established subrenal human islet allografts...
  51. pmc Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses
    Roland Grenningloh
    Department of Medicine, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Exp Med 201:615-26. 2005
    ..In addition, Ets-1-deficient Th1 cells also produce a very high level of interleukin 10. Thus, Ets-1 plays a crucial and unique role in the reciprocal regulation of inflammatory and antiinflammatory Th responses...
  52. ncbi Regulation of the pancreatic duodenal homeobox-1 protein by DNA-dependent protein kinase
    Patricia Lebrun
    INSERM U145, Faculty of Medicine, IFR50 Nice, France
    J Biol Chem 280:38203-10. 2005
    ..e. glut2 and glucokinase. Our study demonstrates that radiation, through the activation of DNA-PK, may regulate PDX-1 protein expression...
  53. pmc Role of genomic instability and p53 in AID-induced c-myc-Igh translocations
    Almudena R Ramiro
    Laboratory of Molecular Immunology, The Rockefeller University, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Nature 440:105-9. 2006
    ..Our findings reveal a pathway for surveillance and protection against AID-dependent DNA damage, leading to chromosomal translocations...
  54. ncbi The autoimmune diabetes locus Idd9 regulates development of type 1 diabetes by affecting the homing of islet-specific T cells
    Hanspeter Waldner
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 65 Lansdowne Street, Boston, MA 02115, USA
    J Immunol 176:5455-62. 2006
    ..Upon transfer, BDC T cells rapidly induced severe insulitis and diabetes in NOD.scid mice, whereas those from BDC-Idd9 mice mediated a milder insulitis and induced diabetes with a significantly ..
  55. ncbi Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice
    Marcelo J Perone
    Thomas E Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    J Immunol 177:5278-89. 2006
    ....
  56. pmc The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination
    Kerstin Kiefer
    Institute for Cancer Research, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Proc Natl Acad Sci U S A 104:2843-8. 2007
    ..However, we reported earlier that CSR can readily occur in Ig transgenic SCID mice lacking DNA-dependent protein kinase (DNA-PK) activity, a critical enzymatic activity for V(D)J recombination...
  57. pmc Analysis of the defect in DNA end joining in the murine scid mutation
    J Harrington
    Department of Pathology, Stanford University School of Medicine, California 94305 5324
    Mol Cell Biol 12:4758-68. 1992
    Murine severe combined immune deficiency (scid) is marked by a 5,000-fold reduction in coding joint formation in V(D)J recombination of antigen receptors...
  58. pmc Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice
    H W Rogers
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Proc Natl Acad Sci U S A 89:1011-5. 1992
    Using T- and B-cell deficient C.B-17 mice with the scid mutation, we have previously documented the existence of a T-cell-independent but interferon gamma-dependent pathway of macrophage activation that confers upon the host partial ..
  59. ncbi A severe combined immunodeficiency mutation in the mouse
    G C Bosma
    Nature 301:527-30. 1983
    The most debilitating human lymphoid deficiency disease, known as severe combined immunodeficiency (SCID), impairs the differentiation of both T and B lymphocytes...
  60. ncbi Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    F Powrie
    DNAX Research Institute of Molecular and Cellular Biology Incorporated, Palo Alto, California 94040, USA
    Immunity 1:553-62. 1994
    We have described a murine model of IBD that was induced in C.B-17 scid mice by transfer of the CD45RBhi subpopulation of CD4+ T cells from normal BALB/c mice and could be prevented by cotransfer of the CD45RBlo CD4+ T cell subset...
  61. pmc Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8
    J D Sipley
    Biology Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Proc Natl Acad Sci U S A 92:7515-9. 1995
    ..This location is coincident with that of XRCC7, the gene that complements the DNA double-strand break repair and V(D)J recombination defects (where V is variable,..
  62. ncbi Development of B cells in scid mice with immunoglobulin transgenes: implications for the control of V(D)J recombination
    Y Chang
    Fox Chase Cancer Center, Institute for Cancer Research, Philadelphia, Pennsylvania 19111, USA
    Immunity 2:607-16. 1995
    The inability of scid pro-B cells to progress to the pre-B and B cell stages is believed to be caused by a defective recombinase activity that fails to resolve chromosomal breaks resulting from attempted V(D)J recombination...
  63. pmc Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse
    A G Murray
    Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 91:9146-50. 1994
    ..This small animal model may permit evaluation of potential therapeutic reagents that inhibit human T-cell-mediated injury...
  64. ncbi Bcl-2 expression promotes B- but not T-lymphoid development in scid mice
    A Strasser
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Nature 368:457-60. 1994
    Expression of antigen receptors is vital for the development of B and T lymphocytes. In mice with the scid mutation, which are unable to make productive rearrangements of their immunoglobulin and T-cell receptor (TCR) genes, lymphopoiesis ..
  65. pmc Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice
    E Szomolanyi-Tsuda
    Department of Pathology, University of Massachusetts Medical Center, Worcester 01655
    Am J Pathol 144:359-71. 1994
    ..Analysis of the spleen leukocyte population indicated that the cells expressed high levels of class I major histocompatibility complex antigens and were resistant to lysis by activated natural killer cells...
  66. pmc High frequency of normal DJH joints in B cell progenitors in severe combined immunodeficiency mice
    J L Pennycook
    Department of Immunology, University of Toronto, Ontario, Canada
    J Exp Med 178:1007-16. 1993
    The severe combined immunodeficiency (scid) mouse has a defective V(D)J recombinase activity that results in arrested lymphoid development at the pro-B cell stage in the B lineage...
  67. pmc Homozygous scid/scid;beige/beige mice have low levels of spontaneous or neonatal T cell-induced B cell generation
    D E Mosier
    Division of Immunology, Medical Biology Institute, La Jolla, California 92137
    J Exp Med 177:191-4. 1993
    The autosomal recessive scid mutation results in defective immunoglobulin and T cell receptor gene rearrangement. The scid mutation occurred in the allotype congenic C.B-17 line, and up to 25% of C...
  68. ncbi Normal D-JH rearranged products of the IgH gene in SCID mouse bone marrow
    R Araki
    Cell Biology Laboratory, Department of Radiobiology, Radiation Effects Research Foundation, 8 6 Nakagawa 1 chome, Nagasaki 850, Japan
    Int Immunol 8:1045-53. 1996
    b>SCID mice are profoundly immunodeficient, resulting from an inability to carry out the V(D)J recombination reaction during both B cell and T cell development...
  69. ncbi Mutations in the p53 and SCID genes cooperate in tumorigenesis
    M Nacht
    Howard Hughes Medical Institute, Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 10:2055-66. 1996
    ..The severe combined immune deficiency (scid) focus encodes the catalytic subunit of DNA protein kinase (DNA-PKcs), a protein complex that has a role in the ..
  70. pmc Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse
    T Blunt
    Medical Research Council Cell Mutation Unit, University of Sussex, Brighton, United Kingdom
    Proc Natl Acad Sci U S A 93:10285-90. 1996
    ..functions in DNA double-strand break repair and V(D)J recombination, and recent evidence has shown that mouse scid cells are defective in DNA-PKcs...
  71. ncbi The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching
    A Rolink
    Basel Institute for Immunology, Switzerland
    Immunity 5:319-30. 1996
    ..the capacity of precursor B cells from normal (BDF1) and V(D)J recombinase-deficient (RAG-27) or defective (SCID) mice to be induced by a CD40-specific monoclonal antibody and IL-4 to epsilon H chain gene transcription and to S ..
  72. ncbi Effect of different Ig transgenes on B cell differentiation in scid mice
    Y Chang
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int Immunol 9:373-80. 1997
    ..study we show that the ability of bone marrow pre-B cells to differentiate into B cells in H/L chain transgenic scid mice correlates with the ability of the transgenes to inhibit initiation of endogenous kappa gene rearrangement...
  73. ncbi Growth retardation and leaky SCID phenotype of Ku70-deficient mice
    Y Gu
    The Howard Hughes Medical Institute, Children s Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 7:653-65. 1997
    ..These unanticipated features of the Ku70-deficient phenotype with respect to lymphocyte development and V(D)J recombination may reflect differential functions of the three DNA-PK components...
  74. ncbi Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
    C Morrison
    Research Institute of Molecular Pathology, Vienna, Austria
    Nat Genet 17:479-82. 1997
    ..Mutation of the gene for DNA-PK catalytic subunit (Prkdc) cases defective antigen receptor V(D)J recombination and arrests B- and T-lymphocyte development in severe ..
  75. ncbi A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
    Y Gao
    Howard Hughes Medical Institute, The Children s Hospital, The Center for Blood Research and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 9:367-76. 1998
    ..Finally, while DNA-PK-null fibroblasts exhibited increased IR sensitivity, DNA-PKcs-deficient ES cells did not. We conclude that Ku70 and Ku80 may have functions in V(D)J recombination and DNA repair that are independent of DNA-PKcs...
  76. pmc Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation
    M A Bogue
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 95:15559-64. 1998
    ..It is noteworthy, however, that severe combined immunodeficient (SCID) mice, which bear a nonnull mutation in DNA-PKcs, are substantially less impaired in forming signal joints than ..
  77. pmc Catalytic subunit of DNA-dependent protein kinase: impact on lymphocyte development and tumorigenesis
    A Kurimasa
    Life Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Proc Natl Acad Sci U S A 96:1403-8. 1999
    ..Furthermore, inactivation of DNA-PKcs leads to hyperplasia and dysplasia of the intestinal mucosa and production of aberrant crypt foci, suggesting a novel role of DNA-PKcs in tumor suppression...
  78. pmc Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice
    Y Gu
    Howard Hughes Medical Institute, The Children s Hospital, and Center for Blood Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:2668-73. 2000
    ..We conclude that normal development of the nervous system depends on the four evolutionarily conserved nonhomologous DNA end joining factors...
  79. ncbi Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis
    K E Gurley
    Fred Hutchinson Cancer Research Center C1 015, 1100 Fairview Ave N, Seattle, WA 90109 1024, USA
    Curr Biol 11:191-4. 2001
    ..b>Prkdc(scid/scid) mice have a homozygous mutation in the gene encoding DNA-PK(cs) and, like Atm(-/-) mice, are viable and ..
  80. pmc Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development
    J Sekiguchi
    The Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:3243-8. 2001
    ..Finally, in dramatic contrast to effects on Lig4 deficiency, ATM deficiency causes early embryonic lethality in Ku- or DNA-PKcs-deficient mice, providing evidence for an NHEJ-independent role for the DNA-PK holoenzyme...
  81. ncbi Elevated breast cancer risk in irradiated BALB/c mice associates with unique functional polymorphism of the Prkdc (DNA-dependent protein kinase catalytic subunit) gene
    Y Yu
    Department of Radiation Oncology, The University of Texas Medical Branch, Galveston 77555, USA
    Cancer Res 61:1820-4. 2001
    ..In this study, we report the identification of two BALB/c strain-specific polymorphisms in the coding region of Prkdc, the gene encoding the DNA-dependent protein kinase catalytic subunit, which is known to be involved in DNA double-..
  82. ncbi NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells
    Mamoru Ito
    Central Institute for Experimental Animals, Department of Pediatrics, Graduate School of Medicine, Kyoto University, 1430 Nogawa, Miyamae, Kawasaki, Kanagawa 216 0001, Japan
    Blood 100:3175-82. 2002
    ..animal recipient for xenotransplantation, NOD/SCID/gamma(c)(null) mice double homozygous for the severe combined immunodeficiency (SCID) mutation and interleukin-2Rgamma (IL-2Rgamma) allelic mutation (gamma(c)(null)) were generated ..
  83. pmc Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
    Silvia Espejel
    Department of Immunology and Oncology, National Centre of Biotechnology, E 28049 Madrid, Spain
    EMBO J 21:6275-87. 2002
    ..These results suggest a critical role of DNA-PKcs in both cancer and aging...
  84. pmc DNA-dependent protein kinase activity is not required for immunoglobulin class switching
    Gayle C Bosma
    Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    J Exp Med 196:1483-95. 2002
    ..To test whether DNA-PKcs activity is essential for CSR, we examined whether IgM(+) B cells from scid mice with site-directed H and L chain transgenes were able to undergo CSR...
  85. ncbi During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities
    Teresa P DiLorenzo
    Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    Clin Immunol 105:332-41. 2002
    ..NIT-1 cells represent an unlimited peptide source that will allow for the future isolation and sequencing of the novel multiple epitopes targeted early in the autoimmune response by pathogenic CD8(+) T cells...
  86. ncbi Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model
    Hidefumi Hiramatsu
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawaharacho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Blood 102:873-80. 2003
    ..We report ontogenic, functional, and histologic examination results of reconstituted human lymphocytes in NOD/SCID/ gammacnull mice after the transplantation of human cord blood (CB) CD34+ cells...
  87. ncbi Adenoma multiplicity in irradiated Apc(Min) mice is modified by chromosome 16 segments from BALB/c
    Natalie L Degg
    Radiation Effects Department, National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 0RQ, United Kingdom
    Cancer Res 63:2361-3. 2003
    ..This has been confirmed by finding BALB/c-specific functional polymorphism in Prkdc, a gene on mouse chromosome 16 that encodes the catalytic subunit of DNA-dependent protein kinase...
  88. ncbi Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions
    Adam J L Cook
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, NSW, Australia
    J Immunol 171:6556-64. 2003
    ..In SCID mice, V(D)J recombination is blocked because the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) protein ..
  89. pmc Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice
    Silvia Espejel
    Molecular Oncology Program, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, E 28029, Madrid, Spain
    EMBO Rep 5:503-9. 2004
    ..In conclusion, these data link the dual role of DNA-PKcs in DNA repair and telomere length maintenance to organismal ageing and cancer...
  90. ncbi The kinase activity of DNA-PK is required to protect mammalian telomeres
    Susan M Bailey
    Department of Environmental and Radiological Health Sciences, Colorado State Univeristy, Fort Collins 80523, USA
    DNA Repair (Amst) 3:225-33. 2004
    ..These results indicate that the kinase activity of DNA-PK is crucial to reestablishing a protective terminal structure, specifically on telomeres replicated by leading-strand DNA synthesis...
  91. pmc Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs
    Silvia Espejel
    Molecular Oncology Program, Spanish National Cancer Center CNIO, E 28029 Madrid, Spain
    J Cell Biol 167:627-38. 2004
    ..These results support the notion that absence of telomerase and short telomeres in combination with DNA repair deficiencies accelerate the aging process without impacting on tumorigenesis...
  92. ncbi The life and death of DNA-PK
    Spencer J Collis
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21231, USA
    Oncogene 24:949-61. 2005
    ..This review promotes the inhibition of DNA-PK as a valid approach to enhance the tumor-cell-killing effects of treatments such as IR...
  93. pmc DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA
    Ana Maria Dragoi
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    EMBO J 24:779-89. 2005
    ..Thus, our findings establish a novel role for DNA-PKcs in CpG-DNA signaling and define a CpG-DNA/DNA-PKcs/Akt pathway...
  94. pmc Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development
    Sean Rooney
    Howard Hughes Medical Institute, Children s Hospital, CBR Institute for Biomedical Research, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:2471-5. 2005
    ..We found that ATM/Artemis double-deficient mice were viable and born in normal Mendelian numbers. Therefore, we conclude that DNA-PKcs has Artemis-independent functions in CSR and normal development...
  95. ncbi Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells
    Leonard D Shultz
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Immunol 174:6477-89. 2005
    ..report the development and characterization of a new genetic stock of IL-2R common gamma-chain deficient NOD/LtSz-scid (NOD-scid IL2Rgamma(null)) mice and document their ability to support human mobilized blood HSC engraftment and ..
  96. pmc Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice
    Fumihiko Ishikawa
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, 44 Binney St, no 770, Boston, MA 02115, USA
    Blood 106:1565-73. 2005
    Here we report that a new nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse line harboring a complete null mutation of the common cytokine receptor gamma chain (NOD/SCID/interleukin 2 receptor [IL2r] gamma(null)) ..
  97. ncbi Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:93-103. 2006
    ..These findings define an innate immune response to DNA linked to type I interferon production...
  98. ncbi Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells
    Manuela Battaglia
    San Raffaele Scientific Institute, Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Diabetes 55:1571-80. 2006
    ..Rapamycin plus IL-10 treatment, promoting distinct subsets of Tr cells, may constitute a novel and potent tolerance-inducing protocol for immune-mediated diseases...
  99. ncbi Cytotoxic T-cells from T-cell receptor transgenic NOD8.3 mice destroy beta-cells via the perforin and Fas pathways
    Nadine L Dudek
    St Vincent s Institute, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia
    Diabetes 55:2412-8. 2006
    ..Therefore, NOD8.3 T-cells use both perforin and Fas pathways to kill beta-cells and the surprising blockade of NOD8.3 T-cell-mediated beta-cell death by SOCS-1 overexpression may be due in part to reduced target cell recognition...
  100. pmc DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse
    Richard S Maser
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell Biol 27:2253-65. 2007
    ....
  101. pmc In CD4+ T-cell-induced diabetes, macrophages are the final effector cells that mediate islet beta-cell killing: studies from an acute model
    Boris Calderon
    Washington University School of Medicine, Department of Pathology and Immunology, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Pathol 169:2137-47. 2006
    ..5 T-cell clone was established. Transfer of activated BDC T cells into NOD.scid mice resulted in diabetes within a week, characterized by strong inflammatory reaction...

Research Grants30

  1. DNA REPAIR/V(D)J RECOMBINATION--FUNCTIONAL STUDY
    Guillermo Taccioli; Fiscal Year: 2001
    ..the use of other existing DNA repair cell mutants as well as fibroblasts from severe combined immune deficient (SCID) patients...
  2. EXPERIMENTAL DIABETIC AUTONOMIC NEUROPATHY
    ROBERT EDWARD SCHMIDT; Fiscal Year: 2010
    ..Thus, we are poised to understand the pathogenesis and develop novel therapies for diabetic autonomic neuropathy. ..
  3. Regulation of Recall Responses During Ehrlichiosis
    Gary M Winslow; Fiscal Year: 2010
    ..By defining optimal CD4 T cell immune correlates, and the role of memory CD8 T cells during recall responses, the proposed studies will contribute to the development of therapies and vaccines for ehrlichioses and related infections. ..
  4. Hypocretin Neurons
    Anthony N van den Pol; Fiscal Year: 2010
    ..Understanding the role of the endogenous opioid in hypocretin cells should also facilitate the understanding and treatment of narcolepsy. ..
  5. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2009
    ..e. SCID and AGR129 mice)...
  6. 5th Comparative Medicine Resource Center Director Mtg.
    Stephen Barthold; Fiscal Year: 2008
    ....
  7. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2008
    ..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  8. KILLER CELLS AND ALCOHOL
    ZUHAIR BALLAS; Fiscal Year: 2008
    ..Preliminary data prompted the hypothesis that ETOH blunts the enhanced NK activity induced by CpG ODN [unreadable] [unreadable]..
  9. Immunodeficiency and Neuronal Function
    JOHN PETITTO; Fiscal Year: 2008
    ....
  10. Control of Dendritic Cell Generation and Function by Tumor
    Michael Shurin; Fiscal Year: 2008
    ..Additionally, understanding the mechanisms responsible for DC dysfunction in cancer will serve as a basis for developing novel therapeutic approaches for patients with cancer. ..
  11. CD8 T Cell Reactivity to IGRP as an Autoimmunity Marker in Type 1 Diabetes
    Teresa Dilorenzo; Fiscal Year: 2007
    ..Tests may also be developed to monitor destructive T cell activity in patients undergoing treatment, so that doctors will be able to know if the treatments are working. [unreadable] [unreadable] [unreadable]..
  12. Mouse Models of Tumor Progression and Therapy Response
    CHRISTOPHER KEMP; Fiscal Year: 2007
    ..These experiments will reveal the molecular and cellular basis for the poor clinical outcome associated with p27 deficient tumors. This knowledge can then be applied to improve treatment design and regimen in the clinical setting. ..
  13. Cell Death in Normal and Diseased Human Epidermis
    Brian Nickoloff; Fiscal Year: 2006
    ..abstract_text> ..
  14. NEUROPATHOLOGY OF THE AGING SYMPATHETIC NERVOUS SYSTEM
    Robert Schmidt; Fiscal Year: 2006
    ..The results of these experiments should provide insight not only into autonomic dysfunction, but into a variety of pathologic processes in which NAD is a prominent component. ..
  15. The Role of Double Strand Breaks in Carcinogenesis
    CHRISTOPHER KEMP; Fiscal Year: 2006
    ..p53 response pathway in genetic mutants of putative upstream regulators of p53, notably the P13K family members DNAPK and Atm...
  16. Antibody mediated intracellular bacterial elimination
    Gary Winslow; Fiscal Year: 2006
    ..These studies have also revealed that significant immunity could be achieved in susceptible immunocompromised SCID mice after passive transfer of antibodies...
  17. Prevention of Diabetes with Lipid Immunomodulators
    Teresa Dilorenzo; Fiscal Year: 2005
    ....
  18. PHENOTYPE AND FUNCTION OF SENESCENT KERATINOCYTES
    Brian Nickoloff; Fiscal Year: 2005
    ....
  19. Recombinant murine IL-10 produced in situ by H. pylori
    KATHRYN EATON; Fiscal Year: 2005
    ..pylori, but will also establish a model in which the roles of other cytokines and mediators can be determined, and host and bacterial interactions can be directly evaluated in vivo. ..
  20. HELICOBACTER DIAGNOSTIC ASSAYS FOR LABORATORY MICE
    Stephen Barthold; Fiscal Year: 2004
    ..abstract_text> ..
  21. Neuroimmunology of IL-15
    JOHN PETITTO; Fiscal Year: 2004
    ..abstract_text> ..
  22. CD40-CD154 Interactions in Cryptosporidial Immunity
    ESTHER PONNURAJ; Fiscal Year: 2004
    ..The results will be important for immunodeficient humans chronically infected with the parasite. ..
  23. 3RD ANNUAL MUTANT MOUSE REGIONAL RESOURCE CENTER MEETING
    Stephen Barthold; Fiscal Year: 2003
    ....
  24. FLOW CYTOMETRY INSTRUMENT
    ZUHAIR BALLAS; Fiscal Year: 2001
    ..abstract_text> ..
  25. Development of Cellular Assays of Dengue Virus Infection
    Priscilla Yang; Fiscal Year: 2008
    ..These inhibitors can be used to study how dengue virus interacts with its host, and they may also be useful in developing therapies for the treatment of dengue virus infections. [unreadable] [unreadable] [unreadable]..
  26. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2002
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  27. IL-2 GENE DELETION: NEURODEVELOPMENT AND BEHAVIOR
    JOHN PETITTO; Fiscal Year: 2002
    ..We believe that the proposed research is timely and will lay an essential foundation on which to build in future studies. ..
  28. TUMOR ASSOCIATED DENDRITIC CELLS
    Michael Shurin; Fiscal Year: 2002
    ....
  29. Host and Bacterial Factors in Disease due to H. pylori
    Kathryn A Eaton; Fiscal Year: 2010
    ..This will allow us to hire additional staff to ensure rapid completion of the remaining experiments. With these changes we fully expect to complete these experiments in 2 years. ..
  30. Cytomegalovirus in the Brain
    Anthony N van den Pol; Fiscal Year: 2010
    ..address the hypothesis that the olfactory system is a weak link in the brain's protection against virus in SCID mice...