Prkcz

Summary

Gene Symbol: Prkcz
Description: protein kinase C, zeta
Alias: AI098070, C80388, Pkcz, R74924, aPKCzeta, nPKC-zeta, zetaPKC, protein kinase C zeta type, atypical protein kinase C, protein kinase C zeta subspecies
Species: mouse

Top Publications

  1. ncbi Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway
    M Leitges
    Max Planck Institut fur Experimentelle Endokrinologie, Feodor Lynen Str 7, 30625 Hannover, Germany
    Mol Cell 8:771-80. 2001
  2. ncbi Regulation of cell survival by atypical protein kinase C isozymes
    Hans H Grunicke
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz pregel Str 3, A 6020, Innsbruck, Austria
    Adv Enzyme Regul 43:213-28. 2003
  3. ncbi Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina
    Chieko Koike
    Department of Developmental Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Neurosci 25:10290-8. 2005
  4. ncbi Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport
    Mini P Sajan
    James A Haley Veterans Medical Center and Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 281:17466-73. 2006
  5. ncbi Expression of the atypical protein kinase C (aPKC) isoforms iota/lambda and zeta during mouse embryogenesis
    Judit Kovac
    Max Planck Institute of Experimental Endocrinology, Feodor Lynen Strasse 7, 30625 Hannover, Germany
    Gene Expr Patterns 7:187-96. 2007
  6. pmc Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling
    Sihoon Lee
    Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 0920, USA
    Endocrinology 149:2451-8. 2008
  7. pmc Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells
    Katia Fecchi
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    FASEB J 20:705-7. 2006
  8. ncbi Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in a PKCzeta-dependent manner
    Jason W Triplett
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Science Building, Room 346, Indianapolis, IN 46202 5120, USA
    Mol Cell Biomech 4:13-25. 2007
  9. ncbi The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
    M T Diaz-Meco
    Centro de Biología Molecular Consejo Superior de Investigaciones Cientificas Universidad Autónoma de Madrid
    Cell 86:777-86. 1996
  10. ncbi The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    G Joberty
    Markey Center for Cell Signaling, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0577, USA
    Nat Cell Biol 2:531-9. 2000

Research Grants

  1. beta-Catenin/NF-kappaBeta and Colon Cancer
    Shahid Umar; Fiscal Year: 2004

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. ncbi Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway
    M Leitges
    Max Planck Institut fur Experimentelle Endokrinologie, Feodor Lynen Str 7, 30625 Hannover, Germany
    Mol Cell 8:771-80. 2001
    Here we have addressed the role that zetaPKC plays in NF-kappaB activation using mice in which this kinase was inactivated by homologous recombination...
  2. ncbi Regulation of cell survival by atypical protein kinase C isozymes
    Hans H Grunicke
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz pregel Str 3, A 6020, Innsbruck, Austria
    Adv Enzyme Regul 43:213-28. 2003
  3. ncbi Function of atypical protein kinase C lambda in differentiating photoreceptors is required for proper lamination of mouse retina
    Chieko Koike
    Department of Developmental Biology, Osaka Bioscience Institute, Osaka 565 0874, Japan
    J Neurosci 25:10290-8. 2005
    ..Our data suggest that properly polarized photoreceptors anchor progenitors at the apical edge of the neural retina, which may be essential for building correct laminar organization of the retina...
  4. ncbi Repletion of atypical protein kinase C following RNA interference-mediated depletion restores insulin-stimulated glucose transport
    Mini P Sajan
    James A Haley Veterans Medical Center and Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 281:17466-73. 2006
    The role of atypical protein kinase C (aPKC) in insulin-stimulated glucose transport in myocytes and adipocytes is controversial...
  5. ncbi Expression of the atypical protein kinase C (aPKC) isoforms iota/lambda and zeta during mouse embryogenesis
    Judit Kovac
    Max Planck Institute of Experimental Endocrinology, Feodor Lynen Strasse 7, 30625 Hannover, Germany
    Gene Expr Patterns 7:187-96. 2007
    ..Both, PKC iota/lambda and zeta show highly specific temporal and spatial patterns of expression which may help in distinguishing physiological functions of these isoforms...
  6. pmc Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling
    Sihoon Lee
    Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 0920, USA
    Endocrinology 149:2451-8. 2008
    ..The inability of PKC-zeta to phosphorylate IRS-2 may help determine specific functional roles for IRS-2...
  7. pmc Spatial and temporal regulation of GLUT4 translocation by flotillin-1 and caveolin-3 in skeletal muscle cells
    Katia Fecchi
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    FASEB J 20:705-7. 2006
    ..Taken together, these results indicate that flotillin-1 and caveolin-3 may regulate muscle energy metabolism through the spatial and temporal segregation of key components of the insulin signaling...
  8. ncbi Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in a PKCzeta-dependent manner
    Jason W Triplett
    Department of Cellular and Integrative Physiology, Indiana University School of Medicine, 635 Barnhill Drive, Medical Science Building, Room 346, Indianapolis, IN 46202 5120, USA
    Mol Cell Biomech 4:13-25. 2007
    ..Together, our results suggest that fluid shear stress may regulate IGF-I signaling in osteoblasts in a PKC-zeta-dependent manner...
  9. ncbi The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
    M T Diaz-Meco
    Centro de Biología Molecular Consejo Superior de Investigaciones Cientificas Universidad Autónoma de Madrid
    Cell 86:777-86. 1996
    ..These findings support a role for the atypical PKC subspecies in the control of cell growth and survival...
  10. ncbi The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    G Joberty
    Markey Center for Cell Signaling, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908 0577, USA
    Nat Cell Biol 2:531-9. 2000
    ..with Cdc42-GTP, with a human homologue of the multi-PDZ protein PAR-3 and with the regulatory domains of atypical protein kinase C (PKC) proteins...
  11. ncbi A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
    D Lin
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Nat Cell Biol 2:540-7. 2000
    ..mPAR-6 binds to Cdc42/Rac1 GTPases, and mPAR-3 and mPAR-6 bind independently to atypical protein kinase C (aPKC) isoforms. In vitro, mPAR-3 acts as a substrate and an inhibitor of aPKC...
  12. pmc Role of zeta PKC in B-cell signaling and function
    Pilar Martin
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, E 28049 Madrid, Spain
    EMBO J 21:4049-57. 2002
    The atypical protein kinase C isoform, zeta PKC, has been implicated in the control of extracellular signal-regulated kinase (ERK) and nuclear factor (NF)-kappa B pathways...
  13. pmc Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:3910-8. 2003
    ..In vitro assays showed that zetaPKC directly phosphorylates RelA...
  14. ncbi PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains
    Tomonori Hirose
    Department of Molecular Biology, Yokohama City University Graduate School of Medical Science, Yokohama 236 0004, Japan
    Development 133:1389-98. 2006
    ..These results also provide a clear example of the proper organization of epithelial tissues through the regulation of individual cell polarity...
  15. ncbi Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice
    Henrik Oster
    Laboratory for Signal Transduction, Max Planck Institute of Experimental Endocrinology and Department of Nephrology, Hannover Medical School, Hannover, Germany
    Cancer Res 66:6955-63. 2006
    ....
  16. ncbi Protein kinase C-zeta activation markedly enhances beta-cell proliferation: an essential role in growth factor mediated beta-cell mitogenesis
    Rupangi C Vasavada
    Department of Medicine, Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Diabetes 56:2732-43. 2007
    ....
  17. ncbi Cdc42 is crucial for the establishment of epithelial polarity during early mammalian development
    Xunwei Wu
    University of Copenhagen, Institute of Molecular Pathology, Copenhagen, Denmark
    Dev Dyn 236:2767-78. 2007
    ..Finally, aggregation experiments with endodermal cell lines suggested that Cdc42 might affect formation of adherens and tight junctions by PKCzeta-dependent regulation of the protein levels of p120 catenin and E-cadherin...
  18. pmc Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo
    Anita S Galvez
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Ave, Cincinnati, OH 45267, USA
    Mol Cell Biol 29:104-15. 2009
    ..The atypical protein kinase C (PKC) isoform, PKCzeta, has been shown to interact with the signaling adapter p62, which is important ..
  19. doi Pivotal Advance: PKCzeta is required for migration of macrophages
    Hua Guo
    Research Center of Basic Medical Sciences and Cancer Institute and Hospital, Tianjin, 300060, China
    J Leukoc Biol 85:911-8. 2009
    ..Our previous study reported that atypical protein kinase C zeta (PKCzeta) regulates epidermal growth factor-induced chemotaxis of human breast cancer cells...
  20. pmc The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis
    Laura L Yates
    Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 19:2251-67. 2010
    ....
  21. doi Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex
    Xiang yao Li
    Department of Physiology, Faculty of Medicine, Center for the Study of Pain, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Science 330:1400-4. 2010
    ..Microinjection of ZIP into the ACC blocked behavioral sensitization. These results suggest that PKMζ in the ACC acts to maintain neuropathic pain. PKMζ could thus be a new therapeutic target for treating chronic pain...
  22. pmc BDNF facilitates L-LTP maintenance in the absence of protein synthesis through PKMζ
    Fan Mei
    School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
    PLoS ONE 6:e21568. 2011
    ..These results suggest that BDNF sustains L-LTP through PKMζ in a protein synthesis-independent manner, revealing an unexpected link between BDNF and PKMζ...
  23. pmc Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis
    Hirotaka Tao
    Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology CDB, Chuo Ku, Kobe, Japan
    Dev Biol 364:138-48. 2012
    ..The cell polarity phenotype was efficiently rescued by nuclear but not cytoplasmic Pk2, demonstrating the nuclear localization of Pk2 is critical for its function...
  24. pmc Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung
    Laura L Yates
    Mammalian Genetics Unit, Medical Research Council, Harwell, UK
    Dev Biol 373:267-80. 2013
    ..Thus we reveal novel and important roles for Scrib in lung development operating via the PCP pathway, and in regulating junctional complexes and cell cohesion...
  25. pmc Prkcz null mice show normal learning and memory
    Anna M Lee
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, 5858 Horton Street, Suite 200, Emeryville, California 94608, USA
    Nature 493:416-9. 2013
    Protein kinase M-ζ (PKM-ζ) is a constitutively active form of atypical protein kinase C that is exclusively expressed in the brain and implicated in the maintenance of long-term memory...
  26. pmc PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory
    Lenora J Volk
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 493:420-3. 2013
    ..Notably, ZIP still reverses LTP in PKC-ζ/PKM-ζ knockout mice, indicating that the effects of ZIP are independent of PKM-ζ...
  27. ncbi Protein kinase Czeta is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells
    Roman Iakoubov
    Department of Physiology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Endocrinology 148:1089-98. 2007
    ..Because the atypical protein kinase C (PKC), PKCzeta, is involved in FA signaling in many cells, the role of PKCzeta in FA-induced GLP-1 ..
  28. ncbi Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells
    P Crespo
    Molecular Signaling Unit, National Institute of Dental Research, NIH, Bethesda, Maryland 20892, USA
    Biochem Biophys Res Commun 213:266-72. 1995
    ..Taken together, our findings demonstrate that mammalian PKC zeta does not directly participate in signaling pathways involved in oncogenic transformation...
  29. pmc Protein kinase C-theta is specifically localized on centrosomes and kinetochores in mitotic cells
    M Passalacqua
    Institute of Biological Chemistry, University of Genoa, Viale Benedetto XV, 1 16132 Genoa, Italy
    Biochem J 337:113-8. 1999
    ..We propose that, unlike other members of the PKC family, PKC-straight theta may play a role in cell proliferation...
  30. ncbi Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells
    Naoyuki Manabe
    Department of Molecular Biology, Yokohama City University School of Medicine, Kanazawa Ku, Yokohama, Japan
    Dev Dyn 225:61-9. 2002
    ....
  31. ncbi Differentiation of nonbeating embryonic stem cells into beating cardiomyocytes is dependent on downregulation of PKC beta and zeta in concert with upregulation of PKC epsilon
    Xuan Zhou
    Department of Cell Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Dev Biol 255:407-22. 2003
    ..e., ionic exchange glass beads) with recently developed methods for differentiating ES cells creates a possible novel technique for investigating differentiation of ES cells into cardiomyocytes as well as other cell types...
  32. ncbi EGF-stimulated signaling by means of PI3K, PLCgamma1, and PKC isozymes regulates branching morphogenesis of the fetal mouse submandibular gland
    Noriko Koyama
    Department of Cell Biology and Anatomical Sciences, The Sophie Davis School of Biomedical Education, The City University of New York Medical School, New York, New York 10031, USA
    Dev Dyn 227:216-26. 2003
    ..These findings indicate that signaling from the EGF receptor in the fetal mouse SMG varies with development and triggers stimulatory effects by means of ERK-1/2 and PI3K but inhibitory effects by means of PKC isozymes...
  33. ncbi Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
    Hong Rui Wang
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M56 1x5, Canada
    Science 302:1775-9. 2003
    ..b>Atypical protein kinase C zeta (PKCzeta), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruited Smurf1 to cellular ..
  34. pmc Atypical PKC-zeta regulates SDF-1-mediated migration and development of human CD34+ progenitor cells
    Isabelle Petit
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 115:168-76. 2005
    ..Our results demonstrate a central role for PKC-zeta in SDF-1-dependent regulation of hematopoietic stem and progenitor cell motility and development...
  35. ncbi Thyroid hormones increase inducible nitric oxide synthase gene expression downstream from PKC-zeta in murine tumor T lymphocytes
    Maria Laura Barreiro Arcos
    Laboratorio de Inmunofarmacologia, CEFYBO CONICET, Paraguay 2155 1121 Buenos Aires, Argentina
    Am J Physiol Cell Physiol 291:C327-36. 2006
    ..These results show, for the first time, that differential intracellular signals are involved in TH modulation of lymphocyte physiology and pathophysiology...
  36. ncbi Dual alterations in casein kinase I-epsilon and GSK-3beta modulate beta-catenin stability in hyperproliferating colonic epithelia
    Shahid Umar
    Div of Gastroenterology, Univ of Texas Medical Branch, Galveston, TX 77555 0632, USA
    Am J Physiol Gastrointest Liver Physiol 292:G599-607. 2007
    ....
  37. ncbi Effects of PKC zeta on early genome transcription activation in mouse 1-cell stage fertilized eggs
    Bing Zhi Yu
    Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, Liaoning Province, PR China
    Cell Biochem Funct 25:619-24. 2007
    ..PKC zeta specific inhibitor can also inhibit early transcription in 1-cell stage fertilized eggs (p < 0.05). The results suggest that PKC zeta participates in early transcription activation in mouse 1-cell stage fertilized eggs...
  38. pmc Wnt5a is essential for intestinal elongation in mice
    Sara Cervantes
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Dev Biol 326:285-94. 2009
    ..Thus, our study demonstrates that Wnt5a functions as a critical regulator of midgut formation and morphogenesis in mammals...
  39. pmc Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance
    M P Sajan
    Research Service, James A Haley Veterans Hospital, Tampa, FL 33612, USA
    Diabetologia 52:1197-207. 2009
    Previous findings in rodents used as a model of diabetes suggest that insulin activation of atypical protein kinase C (aPKC) is impaired in muscle, but, unexpectedly, conserved in liver, despite impaired hepatic protein kinase B (PKB/Akt)..
  40. pmc Protein kinase Czeta regulates Cdk5/p25 signaling during myogenesis
    Aurelie de Thonel
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, 20521 Turku, Finland
    Mol Biol Cell 21:1423-34. 2010
    ....
  41. doi PKCzeta regulates cell polarisation and proliferation restriction during mammary acinus formation
    Jacqueline Whyte
    UCD Conway Institute and School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland
    J Cell Sci 123:3316-28. 2010
    ..Paralleling these contributions, we found that low levels of PKCζ mRNA expression are associated with more 'poorly differentiated' tumours and a poor outcome in a cohort of 295 breast cancer patients...
  42. pmc Differential dephosphorylation of the protein kinase C-zeta (PKCζ) in an integrin αIIbβ3-dependent manner in platelets
    Azad Mayanglambam
    Department of Physiology, Temple University School of Medicine, 3420 N Broad Street Philadelphia, PA 19140, USA
    Biochem Pharmacol 82:505-13. 2011
    ..This differential dephosphorylation of PKCζ might be an important regulatory mechanism for platelet functional responses...
  43. doi Brd2 is required for cell cycle exit and neuronal differentiation through the E2F1 pathway in mouse neuroepithelial cells
    Mami Tsume
    Department of Molecular Embryology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka Prefectural Hospital Organization, Izumi, Osaka 594 1101, Japan
    Biochem Biophys Res Commun 425:762-8. 2012
    ..These findings suggest that Brd2 is required for cell cycle exit and neuronal differentiation of neuroepithelial cells through the E2F1 pathway during mouse CNS development...
  44. pmc Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling
    Sebastian Seidl
    Biotechnology Centre of Oslo, University of Oslo, NO 0349, Oslo, Norway
    Biol Open 1:436-45. 2012
    ..Taken together, we show for the first time, that the atypical isoforms aPKCι and ζ underly different mechanisms regarding their regulation of subcellular localization and translocation into the nucleus in MDCK cells...
  45. doi Atypical protein kinase C and Par3 are required for proteoglycan-induced axon growth inhibition
    Seong il Lee
    Department of Neurobiology and Behavior and Program in Neuroscience, Stony Brook University, Stony Brook, New York 11794, USA
    J Neurosci 33:2541-54. 2013
    ..Here we provide biochemical and functional evidence that atypical protein kinase C (PKCζ) and polarity (Par) complex proteins mediate axon growth inhibition...
  46. pmc Soluble CD40 ligand stimulates CD40-dependent activation of the β2 integrin Mac-1 and protein kinase C zeda (PKCζ) in neutrophils: implications for neutrophil-platelet interactions and neutrophil oxidative burst
    Rong Jin
    Vascular Biology and Stroke Research Laboratory, Department of Neurosurgery, Louisiana State University Health Science Center in Shreveport, Shreveport, Louisiana, United States of America
    PLoS ONE 8:e64631. 2013
    ..These findings may contribute to a better understanding of the underlying mechanisms by which sCD40L/CD40 pathway contributes to inflammation and vascular diseases...
  47. doi The Hippo pathway member Nf2 is required for inner cell mass specification
    Katie Cockburn
    Department of Molecular Genetics, University of Toronto, ON M5S 1A8, Canada
    Curr Biol 23:1195-201. 2013
    ..Together, these data establish a clear role for Nf2 upstream of Yap in the preimplantation embryo and demonstrate that Hippo signaling is essential to segregate the ICM from the TE. ..
  48. doi The tumor suppressor Lgl1 forms discrete complexes with NMII-A and Par6α-aPKCζ that are affected by Lgl1 phosphorylation
    Inbal Dahan
    Department of Biochemistry and Molecular Biology, The Institute of Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Cell Sci 127:295-304. 2014
    ..These results provide new insights into the mechanism regulating the interaction between Lgl1, NMII-A, Par6α and aPKCζ in polarized migrating cells. ..
  49. pmc Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition
    Jerome Gros
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 343:1253-6. 2014
    ..This work shows that limb buds initiate earlier than previously thought, as a result of localized EMT rather than differential proliferation rates. ..
  50. pmc Common and distinctive localization patterns of Crumbs polarity complex proteins in the mammalian eye
    Jin Young Kim
    Shriners Hospitals Pediatric Research Center and Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Gene Expr Patterns 17:31-7. 2015
    ..These findings suggest that core Crumbs polarity complex proteins exert common and independent functions depending on cellular context...
  51. pmc Hyperglycemia stimulates p62/PKCζ interaction, which mediates NF-κB activation, increased Nox4 expression, and inflammatory cytokine activation in vascular smooth muscle
    Gang Xi
    Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, North Carolina, USA and College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, China
    FASEB J 29:4772-82. 2015
    ....
  52. pmc Phosphorylation of GAP-43 (growth-associated protein of 43 kDa) by conventional, novel and atypical isotypes of the protein kinase C gene family: differences between oligopeptide and polypeptide phosphorylation
    S A Oehrlein
    Institute of Physiological Chemistry, Johannes Gutenberg University, Mainz, Germany
    Biochem J 317:219-24. 1996
    ..These results suggest that there are multiple sites of interaction between GAP-43 and PKC...
  53. pmc Hydrogen sulfide and L-cysteine increase phosphatidylinositol 3,4,5-trisphosphate (PIP3) and glucose utilization by inhibiting phosphatase and tensin homolog (PTEN) protein and activating phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (A
    Prasenjit Manna
    Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA
    J Biol Chem 286:39848-59. 2011
    ..This study provides evidence for a molecular mechanism by which H(2)S or LC can up-regulate the insulin-signaling pathways essential for maintenance of glucose metabolism...
  54. pmc Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts
    Carlota García-Hoz
    Departamento de Biologia Molecular and Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid CSIC UAM, 28049 Madrid, Universidad Autonoma de Madrid, Spain
    J Biol Chem 287:7792-802. 2012
    ..Taken together, our results show that PKCζ is essential for Gq-dependent ERK5 activation in cardiomyocytes and cardiac fibroblasts and indicate a key cardiac physiological role for the Gα(q)/PKCζ/ERK5 signaling axis...
  55. pmc Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin
    Maria F Chacon-Heszele
    Department of Cell Biology, Emory University, 615 Michael Street, Atlanta, Georgia 30322, USA
    Development 139:968-78. 2012
    ..Together, these results indicate that the vertebrate PCP pathway regulates CE and hair cell polarity independently and that a p120-catenin-dependent mechanism regulates CE of the cochlea...
  56. pmc Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retina
    Amel Kechad
    Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Neurosci 32:17197-210. 2012
    ....
  57. pmc Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis
    Li Ma
    Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 152:599-611. 2013
    ..Furthermore, PKCζ and caspase-3 activities are correlated with PHGDH levels in human intestinal tumors. Taken together, this demonstrates that PKCζ is a critical metabolic tumor suppressor in mouse and human cancer...
  58. pmc The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages
    Angel W Lee
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e25580. 2011
    ..Our results demonstrated that CSF-1 dependent Erk activation and proliferation are regulated differentially in progenitors and differentiated cells...
  59. ncbi Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a
    H Wada
    Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
    Biochem Biophys Res Commun 165:533-8. 1989
    ..In a mouse neuroblast cell line, Neuro 2a, down modulation of mRNAs for both PKC alpha and nPKC epsilon was observed in association with in vitro differentiation...
  60. ncbi Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells
    A Kieser
    Institut für Klinische Molekularbiologie und Tumorgenetik, Forschungszentrum für Umwelt and Gesundheit, Munchen, Germany
    Genes Dev 10:1455-66. 1996
    ..In summary, our data suggest that PKC-zeta counteracts v-raf transformation by modulating the expression of the transcription factors junB and egr-1...
  61. ncbi Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiency
    P J Blackshear
    Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
    Brain Res Dev Brain Res 96:62-75. 1996
    ....
  62. ncbi Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development
    G Balasubramanian
    Department of Veterinary Biomedical Sciences, University of Missouri Columbia, 65211, USA
    J Craniofac Genet Dev Biol 20:26-34. 2000
    ....
  63. ncbi The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development
    C M Pauken
    Molecular and Cellular Biology Program, Department of Biology, Arizona State University, Tempe, Arizona, 85287 1501, USA
    Dev Biol 223:411-21. 2000
    ..Two isotypes have a stage-dependent nuclear localization. In addition, within each blastomere PKC isotypes occupy different subcellular locations in a stage-dependent fashion...
  64. ncbi RhoA-dependent murine prostate cancer cell proliferation and apoptosis: role of protein kinase Czeta
    Paramita M Ghosh
    Department of Surgery, University of Texas Health Science Center, San Antonio, Texas, USA
    Cancer Res 62:2630-6. 2002
    ..The atypical protein kinase C (PKC) isoform PKCzeta, which is downstream of PI3K, was activated in cells expressing active RhoA...
  65. ncbi Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells
    Shangwu Chen
    Immunology Group, Institute of Cell and Molecular Sciences, St Barts and The Royal London School of Medicine, Queen Mary University of London, London EC1A 7BE, UK
    Int Immunol 15:403-9. 2003
    ..These results suggest that CIS regulates PKC activation, and that this may be important for the activation of both the AP-1 and NF-kappaB pathways in TCR signaling...
  66. ncbi Dose-dependent differential expression of protein kinase C isozymes in mouse lymphocytes after gamma irradiation in vivo and ex vivo
    Prajakta A Varadkar
    Radiation Biology Division, Bhabha Atomic Research Centre, Mumbai 4000 85, India
    Radiat Res 159:453-7. 2003
    ..The response of Prkcz was found to be similar to that of Prkcd...
  67. ncbi Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta
    Susanna Koponen
    Department of Neurobiology, A I Virtanen Institute for Molecular Sciences, University of Kuopio, Finland
    J Neurochem 86:442-50. 2003
    ..Altogether, the results indicate that PKCzeta activation is a downstream signal in NMDA-induced death of cortical neurons...
  68. ncbi PKC zeta II, a small molecule of protein kinase C zeta, specifically expressed in the mouse brain
    Takaaki Hirai
    Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, 113 8657 Tokyo, Japan
    Neurosci Lett 348:151-4. 2003
    ..An alternative promoter for PKCzetaII was localized in intron 4 of the PKCzeta gene. The specificity of PKCzetaII expression can be regulated at the transcription level in a cell-type-specific manner...
  69. ncbi Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol
    Patricia Cogram
    Neural Development Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Hum Mol Genet 13:7-14. 2004
    ..Hindgut cell proliferation was stimulated specifically by inositol, an effect that required activation of PKCbetaI. Our findings reveal an essential role of specific PKC isoforms in mediating the prevention of mouse NTDs by inositol...
  70. pmc Identification of PKCzetaII: an endogenous inhibitor of cell polarity
    Scott J Parkinson
    Protein Phosphorylation Laboratory, Cancer Research UK, London Research Institute, London, UK
    EMBO J 23:77-88. 2004
    A new member of the atypical protein kinase C (aPKC) family, designated PKCzetaII, is identified in this study. The gene contains no introns and is 98% homologous with the cDNA encoding PKCzeta...
  71. ncbi TRADD interacts with STAT1-alpha and influences interferon-gamma signaling
    Duane R Wesemann
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Nat Immunol 5:199-207. 2004
    ..These data indicate that TRADD may be involved in IFN-gamma signaling by forming a complex with STAT1-alpha within the nucleus and regulating IFN-gamma-mediated STAT1-alpha activation...
  72. pmc Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    EMBO J 23:4595-605. 2004
    ..In contrast, Par-4-/- mice have increased sensitivity to ConA-induced liver damage and IL-4 signaling. This unveils a novel and critical involvement of PKCzeta in the IL-4/Stat6 signaling pathway in vitro and in vivo...
  73. pmc E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    Judith A Tunggal
    Center for Molecular Medicine, University of Cologne CMMC, Cologne, Germany
    EMBO J 24:1146-56. 2005
    ..Surprisingly, our results indicate that E-cadherin is specifically required for tight junction, but not desmosome, formation and this appears to involve signalling rather than cell contact formation...
  74. ncbi Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells
    Guanghu Wang
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta 30912, USA
    J Biol Chem 280:26415-24. 2005
    We have reported that ceramide mediates binding of atypical protein kinase C (PKC) zeta to its inhibitor protein, PAR-4 (prostate apoptosis response-4), thereby inducing apoptosis in differentiating embryonic stem cells...
  75. ncbi Expression profile of protein kinase C isozymes in preimplantation mouse development
    Hesam Dehghani
    Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, N1G 2W1 Canada
    Reproduction 130:441-51. 2005
    ....
  76. pmc Regulation of caspase 9 through phosphorylation by protein kinase C zeta in response to hyperosmotic stress
    Suzanne C Brady
    Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
    Mol Cell Biol 25:10543-55. 2005
    ..and interactions with caspase 9 indicate that the predominant kinase that targets Ser144 is the atypical protein kinase C isoform zeta (PKCzeta)...
  77. ncbi Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells
    Randall S Frey
    Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 281:16128-38. 2006
    ..Thus, PI3Kgamma lies upstream of PKCzeta in the endothelium, and its activation is crucial in signaling NADPH oxidase-dependent oxidant production and subsequent NF-kappaB activation and ICAM-1 expression...
  78. ncbi ANG II-induced cell proliferation is dually mediated by c-Src/Yes/Fyn-regulated ERK1/2 activation in the cytoplasm and PKCzeta-controlled ERK1/2 activity within the nucleus
    Michael D Godeny
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Am J Physiol Cell Physiol 291:C1297-307. 2006
    ..In response to ANG II, the ability of ERK1/2 to remain within the cytoplasm or translocate into the nucleus is controlled by c-Src/Yes/Fyn or heterotrimeric G protein/PKCzeta signaling, respectively...
  79. ncbi Ceramide regulates atypical PKCzeta/lambda-mediated cell polarity in primitive ectoderm cells. A novel function of sphingolipids in morphogenesis
    Kannan Krishnamurthy
    Institute of Molecular Medicine and Genetics, School of Medicine, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Biol Chem 282:3379-90. 2007
    ..Our data suggest a novel mechanism by which a ceramide-induced, apicolateral polarity complex with PKCzeta/lambda regulates primitive ectoderm cell polarity and morphogenesis...
  80. pmc Leishmania donovani-induced ceramide as the key mediator of Akt dephosphorylation in murine macrophages: role of protein kinase Czeta and phosphatase
    Ranadhir Dey
    Dept of Microbiology, Bose Institute, P 1 12, CIT Scheme VII M, Kolkata, India
    Infect Immun 75:2136-42. 2007
    ....
  81. ncbi Microarray analysis and functional genomics identify novel components of melanopsin signaling
    Stuart N Peirson
    Circadian and Visual Neuroscience Group, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Curr Biol 17:1363-72. 2007
    ..Here, we use a microarray-based approach, which we term transcriptional recalibration, coupled with functional genomics to identify downstream targets of melanopsin signaling...
  82. ncbi The chemokine SDF1 controls multiple steps of myogenesis through atypical PKCzeta
    Veysel Odemis
    Institute of Anatomy, Medical Faculty, University of Leipzig, Liebigstr 13, 04103 Leipzig, Germany
    J Cell Sci 120:4050-9. 2007
    ..The potent inhibitory effects of SDF1 on myogenic differentiation point to a major function of CXCR4-PKCzeta signaling in the control of secondary muscle growth...
  83. ncbi Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos
    Noriyuki Nishioka
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe, Hyogo 650 0047, Japan
    Mech Dev 125:270-83. 2008
    ....
  84. doi GSK3 beta mediates acentromeric spindle stabilization by activated PKC zeta
    D Page Baluch
    Cell and Molecular Biosciences, School of Life Sciences, P O Box 874501, Arizona State University, Tempe, AZ 85287 4501, USA
    Dev Biol 317:46-58. 2008
    ....
  85. doi Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance
    Alex M Wolf
    Committee on Developmental Biology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 28:3456-67. 2008
    ..Here we show that atypical protein kinase C (aPKC), is required for Wnt-mediated attraction of commissural axons and proper anterior-posterior (A-P) ..
  86. pmc Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis
    Jayashree Joshi
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    EMBO J 27:2181-93. 2008
    ....
  87. doi VEGF secretion by macrophages is stimulated by lipid and protein components of OxLDL via PI3-kinase and PKCzeta activation and is independent of OxLDL uptake
    Maziar Riazy
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Atherosclerosis 204:47-54. 2009
    ..We conclude that VEGF upregulation is mediated through PI3K and PKCzeta, and does not involve the above three scavenger receptors or require uptake of oxidized LDL...
  88. ncbi KIBRA Co-localizes with protein kinase Mzeta (PKMzeta) in the mouse hippocampus
    Yohei Yoshihama
    Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo
    Biosci Biotechnol Biochem 73:147-51. 2009
    ..These results suggest that KIBRA functions in memory performance via interaction with PKMzeta...
  89. pmc Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma
    Pablo J Fernandez-Marcos
    Spanish National Cancer Research Center, 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain
    Proc Natl Acad Sci U S A 106:12962-7. 2009
    ..These results establish the cooperation between Par-4 and PTEN as relevant for the development of prostate cancer and implicate the NF-kappaB pathway as a critical event in prostate tumorigenesis...
  90. pmc Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones
    Anastasia Mashukova
    Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Cell Sci 122:2491-503. 2009
    ..We conclude that both filamentous keratins and Hsp70 are required for the rescue rephosphorylation of mature atypical PKC, regulating the subcellular distribution and steady-state levels of active PKC iota...
  91. pmc MARCKS modulates radial progenitor placement, proliferation and organization in the developing cerebral cortex
    Jill M Weimer
    UNC Neuroscience Center and the Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Development 136:2965-75. 2009
    ..restriction of key polarity complexes [CDC42, beta-catenin (CTNNB1), N-cadherin (CDH2), myosin IIB (MYOIIB), aPKCzeta, LGL, PAR3, pericentrin, PROM1] is lost...
  92. doi An essential role of the aPKC-Aurora A-NDEL1 pathway in neurite elongation by modulation of microtubule dynamics
    Daisuke Mori
    Department of Genetic Disease Research, Osaka City University, Japan
    Nat Cell Biol 11:1057-68. 2009
    ..Here we identify an atypical protein kinase C (aPKC)-Aurora A-NDEL1 pathway that is crucial for the regulation of microtubule organization during ..
  93. pmc A cell polarity protein aPKClambda is required for eye lens formation and growth
    Yuki Sugiyama
    School of Biological and Biomedical Sciences, University of Durham, Durham, UK
    Dev Biol 336:246-56. 2009
    ..These observations indicate that aPKClambda, a regulator of polarity and apical junctions, is required for development of a lens that is the correct size and shape...
  94. pmc Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications
    Hongwei Yao
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 285:5405-16. 2010
    b>Atypical protein kinase C (PKC) zeta is an important regulator of inflammation through activation of the nuclear factor-kappaB (NF-kappaB) pathway...
  95. doi CBP histone acetyltransferase activity regulates embryonic neural differentiation in the normal and Rubinstein-Taybi syndrome brain
    Jing Wang
    Developmental and Stem Cell Biology Program, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada
    Dev Cell 18:114-25. 2010
    ..Inhibition of histone deacetylation rescued these deficits. Moreover, CBP phosphorylation by atypical protein kinase C zeta was necessary for histone acetylation at neural gene promoters and appropriate differentiation...
  96. pmc The apical complex couples cell fate and cell survival to cerebral cortical development
    Seonhee Kim
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Division of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Neuron 66:69-84. 2010
    ..These data highlight unexpected roles of the apical complex protein Pals1 in cell survival through interactions with mTOR signaling...
  97. pmc PKMzeta inhibition reverses learning-induced increases in hippocampal synaptic strength and memory during trace eyeblink conditioning
    Noelia Madroñal
    Division de Neurociencias, Universidad Pablo de Olavide, Seville, Spain
    PLoS ONE 5:e10400. 2010
    ..induced by HFS and by experience the same? Protein kinase Mzeta (PKMzeta), an autonomously active atypical protein kinase C isoform, plays a key role in the maintenance of LTP induced by tetanic stimulation and the storage of ..
  98. pmc Differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking the G-protein Gα11
    Dieter Paul Hoyer
    Department of Internal Medicine III, University of Cologne, Kerpener Str, 62, 50937 Cologne, Germany
    Cardiovasc Diabetol 9:93. 2010
    ..The present study was therefore designed to determine the role of Gq-protein signalling via Gα11 in diabetes for the expression of PKC isozymes in the coronary vessels...
  99. pmc The glutamate agonist homocysteine sulfinic acid stimulates glucose uptake through the calcium-dependent AMPK-p38 MAPK-protein kinase C zeta pathway in skeletal muscle cells
    Ji Hae Kim
    Department of Anatomy, Korea University College of Medicine, Seoul 136 701, Korea
    J Biol Chem 286:7567-76. 2011
    ..Together, the above results suggest that HCSA may have a beneficial role in glucose metabolism in skeletal muscle cells via stimulation of AMPK...
  100. doi Pulmonary surfactant protein A enhances endolysosomal trafficking in alveolar macrophages through regulation of Rab7
    Vicky Sender
    Division of Cellular Pneumology, Department of Experimental Pneumology, Research Center Borstel, Leibniz Center for Medicine and Biosciences, 23845 Borstel, Germany
    J Immunol 186:2397-411. 2011
    ..The data demonstrate a novel role for SP-A in modulating endolysosomal trafficking via Rab7 in primary AM and define biochemical pathways involved...
  101. doi Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development
    Mathieu Gouzi
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Dev Dyn 240:589-604. 2011
    ..In the chick embryo, Ngn3 independently controls epithelium delamination and differentiation programs. Developmental Dynamics 240:589-604, 2011. © 2011 Wiley-Liss, Inc...

Research Grants1

  1. beta-Catenin/NF-kappaBeta and Colon Cancer
    Shahid Umar; Fiscal Year: 2004
    ..By studying a mechanistic basis of NF-kappaB and beta-catenin mediated increases in cell census, in the absence and presence of chronic inflammation, we may identify new treatment strategies for reducing cancer risk. ..