Genomes and Genes
Gene Symbol: Prkca
Description: protein kinase C, alpha
Alias: AI875142, Pkca, protein kinase C alpha type, PKC-A, PKC-alpha, protein kinase c-alpha
Publications144 found, 100 shown here
- Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylationN Muge Kuyumcu-Martinez
Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
Mol Cell 28:68-78. 2007..These results indicate that inappropriate activation of the PKC pathway contributes to the pathogenic effects of a noncoding RNA...
- Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cellsJae Sung Kim
Department of Life Sciences, Research Center for Biomolecular Nanotechnology, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
J Biol Chem 282:29359-67. 2007..Thus, our results collectively suggest that chondrocyte-specific Cytl1 regulates chondrogenesis as a novel autocrine factor, but not hypertrophic maturation of chondrocytes during cartilage development...
- Protein kinase C(alpha) is required for vanilloid receptor 1 activation. Evidence for multiple signaling pathwaysZoltan Olah
Neuronal Gene Expression Unit, Pain and Neurosensory Mechanisms Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 277:35752-9. 2002..These studies suggest that PKC(alpha) in sensory neurons may elicit or enhance pain during inflammation or ischemia...
- Investigation of the marine compound spongistatin 1 links the inhibition of PKCalpha translocation to nonmitotic effects of tubulin antagonism in angiogenesisAndrea S Rothmeier
Department of Pharmacy, Center for Drug Research, University of Munich, Munich, Germany
FASEB J 23:1127-37. 2009..In addition, the data from the kinase array suggest that different tubulin antagonists might have individual intracellular actions...
- Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epitheliumFang Hao
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
J Biol Chem 286:18104-17. 2011....
- Mechanisms for vascular cell adhesion molecule-1 activation of ERK1/2 during leukocyte transendothelial migrationHiam Abdala-Valencia
Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
PLoS ONE 6:e26706. 2011....
- P/Q-type and T-type calcium channels, but not type 3 transient receptor potential cation channels, are involved in inhibition of dendritic growth after chronic metabotropic glutamate receptor type 1 and protein kinase C activation in cerebellar Purkinje cOlivia S Gugger
Department of Biomedicine Basel, Anatomical Institute, University of Basel, Pestalozzistr 20, CH 4056 Basel, Switzerland
Eur J Neurosci 35:20-33. 2012....
- The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of AktAnnabel Rose
Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
J Biol Chem 279:52500-16. 2004..Our results demonstrate for the first time that several interactions take place between IGF-1 and LHRH receptors in gonadotrope cells...
- Sigma-1 receptor-induced increase in murine spinal NR1 phosphorylation is mediated by the PKCalpha and epsilon, but not the PKCzeta, isoformsDae Hyun Roh
Biotherapy Human Resources Center, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea
Neurosci Lett 477:95-9. 2010..Conversely, the sigma-1 receptor activation of the PKCzeta isoform appears to be involved in a pain signaling pathway that is independent of spinal pNR1 modulation...
- Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteinsS E Rutberg
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892, USA
Oncogene 13:167-76. 1996..These findings suggest distinct functions for different AP-1 proteins in the regulation of events related to keratinocyte maturation...
- The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesisF Zappelli
Institute of Histology and General Embryology, University of Rome La Sapienza, Italy
Dev Biol 180:156-64. 1996..response to transforming growth factor beta, since overexpression of protein kinase C theta, but not of protein kinase C alpha or zeta, in embryonic myoblasts makes these cells sensitive to transforming growth factor beta...
- The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation developmentC M Pauken
Molecular and Cellular Biology Program, Department of Biology, Arizona State University, Tempe, Arizona, 85287 1501, USA
Dev Biol 223:411-21. 2000..Two isotypes have a stage-dependent nuclear localization. In addition, within each blastomere PKC isotypes occupy different subcellular locations in a stage-dependent fashion...
- Requirement for math5 in the development of retinal ganglion cellsS W Wang
Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Genes Dev 15:24-9. 2001..These results imply that math5 is a proneural gene essential for RGC differentiation and that math5 acts upstream to activate brn-3b-dependent differentiation processes in RGCs...
- Math5 is required for retinal ganglion cell and optic nerve formationN L Brown
Departments of Internal Medicine and Human Genetics, University of Michigan, Ann Arbor, MI 48109 0650, USA
Development 128:2497-508. 2001..A small number of nascent RGCs are detected during embryogenesis, but these fail to develop further, suggesting that committed RGCs may also require Math5 function...
- Knockout of PKC alpha enhances insulin signaling through PI3KMichael Leitges
Max Planck Institute for Experimental Endocrinology, 30625 Hannover, Germany
Mol Endocrinol 16:847-58. 2002..muscles and adipocytes of mice in which the ubiquitous conventional diacylglycerol-sensitive PKC isoform, PKC alpha, was knocked out by homologous recombination...
- BETA2/NeuroD1 null mice: a new model for transcription factor-dependent photoreceptor degenerationMark E Pennesi
Department of Ophthalmology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 23:453-61. 2003..Loss of BETA2/NeuroD1 results in an age-related degeneration of both rods and cones...
- PKC-alpha regulates cardiac contractility and propensity toward heart failureJulian C Braz
Department of Pediatrics, University of Cincinnati, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
Nat Med 10:248-54. 2004..Hearts of Prkca-deficient mice are hypercontractile, whereas those of transgenic mice overexpressing Prkca are hypocontractile...
- Evidence for a role of protein kinase C-alpha in urine concentrationLijun Yao
Institute of Pharmacology and Toxicology, University of Tubingen, 72074 Tuebingen, Germany
Am J Physiol Renal Physiol 287:F299-304. 2004..Considering that PKC-beta I and -beta II are coexpressed with PKC-alpha in mouse medullary collecting duct, the present results indicate that conventional PKC isoenzymes cannot fully compensate for each other...
- Diminished loss of proteoglycans and lack of albuminuria in protein kinase C-alpha-deficient diabetic miceJan Menne
Phenos, Hannover, Germany
Diabetes 53:2101-9. 2004..Therefore, PKC-alpha is a possible therapeutic target for the prevention of diabetic albuminuria...
- Foxn4 controls the genesis of amacrine and horizontal cells by retinal progenitorsShengguo Li
Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854 USA
Neuron 43:795-807. 2004..Our data suggest a model in which Foxn4 cooperates with other key retinogenic factors to mediate the multipotent differentiation of retinal progenitors...
- Defective IgG2a/2b class switching in PKC alpha-/- miceChrista Pfeifhofer
Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University, Schoepfstrasse 41, A 6020 Innsbruck, Austria
J Immunol 176:6004-11. 2006..Our genetic data, thus, define PKCalpha as the physiological and nonredundant PKC isotype in signaling pathways that are necessary for T cell-dependent IFN-gamma production and IgG2a/2b Ab responses...
- Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ miceHenrik Oster
Laboratory for Signal Transduction, Max Planck Institute of Experimental Endocrinology and Department of Nephrology, Hannover Medical School, Hannover, Germany
Cancer Res 66:6955-63. 2006....
- Nephrin loss in experimental diabetic nephropathy is prevented by deletion of protein kinase C alpha signaling in-vivoJ Menne
Phenos GmbH, Hannover, Germany
Kidney Int 70:1456-62. 2006..We have recently shown that protein kinase C alpha (PKCalpha)-deficient mice are protected against the development of albuminuria under diabetic conditions...
- Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retinaLiang Feng
Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
Development 133:4815-25. 2006..Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes...
- Identification and characterization of microRNAs expressed in the mouse eyeMarianthi Karali
Telethon Institute for Genetics and Medicine, Naples, Italy
Invest Ophthalmol Vis Sci 48:509-15. 2007..This study was conducted to gain understanding of their eye-related function in mammals, by looking for miRNAs significantly expressed in the mouse eye by means of high-resolution expression analysis...
- Functional PKC in vivo analysis using deficient mouse modelsM Leitges
The Biotechnology Centre of Oslo, University of Oslo, P O Box 1125, Blindern, N 0317, Oslo, Norway
Biochem Soc Trans 35:1018-20. 2007..Exemplary of this approach, recent data generated with PKCalpha-deficient APC(Min) (adenomatous polyposis coli) mice identify PKCalpha in this system acting as a tumour suppressor instead of being a promoter as suggested from PMA data...
- Lim1 is essential for the correct laminar positioning of retinal horizontal cellsRoss A Poche
Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
J Neurosci 27:14099-107. 2007..This study is the first to describe a cell type-specific genetic program that is essential for targeting a discrete retinal neuron population to the proper lamina...
- Syndecan-4 regulates subcellular localization of mTOR Complex2 and Akt activation in a PKCalpha-dependent manner in endothelial cellsChohreh Partovian
Angiogenesis Research Center, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Mol Cell 32:140-9. 2008..Thus, S4-dependent targeting of PKCalpha to the plasma membrane is required for recruitment of mTORC2 components to the rafts and Akt activation...
- PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivoThomas Gruber
Department for Medical Genetics, Molecular and Clinical Pharmacology, Medical University Innsbruck, Austria
Mol Immunol 46:2071-9. 2009The physiological roles of PKC alpha and PKC theta were defined in T cell immune functions downstream of the antigen receptor...
- PKC-alpha modulates TGF-beta signaling and impairs podocyte survivalIrini Tossidou
Department of Medicine, Hannover Medical School, Germany
Cell Physiol Biochem 24:627-34. 2009..In this manuscript we analyzed the role of PKC-alpha (PKCalpha) on TGF-beta1 induced apoptosis in podocytes...
- Podocytic PKC-alpha is regulated in murine and human diabetes and mediates nephrin endocytosisIrini Tossidou
Division of Nephrology, Department of Medicine, Hannover Medical School, Hannover, Germany
PLoS ONE 5:e10185. 2010..Nephrin, is the major component of the glomerular slit diaphragm and loss of nephrin has been well described in rodent models of experimental diabetes as well as in human diabetic nephropathy...
- Erk1/2-dependent phosphorylation of PKCalpha at threonine 638 in hippocampal 5-HT(1A) receptor-mediated signalingPriya Ranjan Debata
Department of Chemistry and the CSI IBR Center for Developmental Neuroscience, The College of Staten Island CUNY, Staten Island, NY 10314, USA
Biochem Biophys Res Commun 397:401-6. 2010..1A receptor (5-HT(1A)-R) causes activation of extracellular signal-regulated protein kinase (Erk) and protein kinase C alpha (PKCalpha) in both hippocampal HN2-5 cells and cultured hippocampal slices from postnatal day-15 (P15) ..
- PKCα suppresses osteoblastic differentiationAkio Nakura
Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Bone 48:476-84. 2011..These results imply that PKCα may have a pivotal role in cell signaling that modulates the differentiation and proliferation of osteoblasts...
- Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse plateletsMatthew T Harper
School of Physiology and Pharmacology, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, United Kingdom
Cell Calcium 48:333-40. 2010..These treatments had no further effect in PKCα(-/-) platelets. These data suggest that PKCα enhances the extent of SOCE in mouse platelets by regulating Ca(2+) entry through the Na(+)/Ca(2+) exchanger...
- Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of HeldDiasynou Fioravante
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
Neuron 70:1005-19. 2011..These experiments establish that PKCα and PKCβ are crucial for PTP and suggest that long-lasting presynaptic calcium increases produced by tetanic stimulation may activate these isoforms to produce PTP...
- Adaptive regulation maintains posttetanic potentiation at cerebellar granule cell synapses in the absence of calcium-dependent PKCDiasynou Fioravante
Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 32:13004-9. 2012..These results suggest that a feedback mechanism allows granule cells to maintain the normal properties of short-term synaptic plasticity even when the mechanism that mediates PTP in wild-type mice is eliminated...
- Role of protein kinase C-α in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ductsYanhua Wang
Emory Univ School of Medicine, Renal Division, Atlanta, GA 30322, USA
Am J Physiol Renal Physiol 304:F233-8. 2013..We conclude that PKCα mediates hypertonicity-stimulated urea transport but is not necessary for vasopressin stimulation of urea permeability in mouse IMCDs...
- Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in plateletsSamantha F Moore
School of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
J Biol Chem 288:3918-28. 2013..Together, these results demonstrate that PKCα and Akt modulate platelet function by phosphorylating and inhibiting GSK3α/β, thereby relieving the negative effect of GSK3α/β on thrombin-mediated platelet activation...
- Munc18-1 is a dynamically regulated PKC target during short-term enhancement of transmitter releaseOzgür Genç
Laboratory of Synaptic Mechanisms, Brain Mind Institute, School of Life Science, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
elife 3:e01715. 2014..Thus, a dynamic PKC phosphorylation/de-phosphorylation cycle of Munc18-1 drives short-term enhancement of transmitter release during PTP. DOI: http://dx.doi.org/10.7554/eLife.01715.001. ..
- Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retinaXiuqian Mu
Department of Biochemistry and Molecular Biology and Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Curr Biol 15:525-30. 2005..Intrinsic rather than extrinsic factors are likely to play the critical roles in determining retinal cell fate...
- Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retinaYasser Elshatory
Center for Aging and Developmental Biology, University of Rochester, Rochester, NY 14642, USA
J Comp Neurol 503:182-97. 2007..Taken together, Isl1 is expressed during the maturation of and is later maintained in retinal ganglion cells and subtypes of amacrine and bipolar cells where it may function in the maintenance of these cells into adulthood...
- PKCalpha regulates platelet granule secretion and thrombus formation in miceOlga Konopatskaya
Department of Physiology and Pharmacology, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
J Clin Invest 119:399-407. 2009..Thrombus formation in vivo was attenuated in Prkca-/- mice, and PKCalpha was required for thrombus formation in vitro, although this PKC isoform did not regulate ..
- Linkage analysis demonstrates that the Timp-2 locus is on mouse chromosome 11W G Stetler-Stevenson
Tumor Invasion and Metastasis Section, National Cancer Institute, Bethesda, Maryland 20892
Genomics 14:828-9. 1992
- Molecular cloning of mouse protein kinase C (PKC) cDNA from Swiss 3T3 fibroblastsS Rose-John
Department of Biochemistry, German Cancer Research Center, Heidelberg
Gene 74:465-71. 1988..The expression of PKC mRNA in fibroblasts is very low and it is not influenced by treatment with the tumor promoter 12-O-tetradecanoyl-13-phorbol-acetate...
- Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brainK Morishige
Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905
FEBS Lett 336:375-80. 1993..These results provide the first demonstration of the cloning and distribution of an inward rectifier potassium channel from the nervous system...
- Genetic mapping of the gene encoding cytochrome b561 to mouse chromosome 11C A Kozak
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Mamm Genome 6:559. 1995
- Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted proteinZ Jiang
Department of Medicine, University of California, Los Angeles 90024, USA
Genomics 50:199-205. 1998..Although the function of macrosialin is unknown, it might play a role in lipoprotein regulation given its binding of oxidized LDL in vitro and its colocalization to a region on chromosome 11 involved in the control of HDL levels...
- Genomic organization and chromosomal localization of the mouse protein kinase C alpha geneTakeshi Hara
Department of Animal Resource Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Gene 291:11-6. 2002..Of the isoforms, PKC alpha is distributed ubiquitously in almost all tissues and involved in various signal transductions...
- Differential expression of protein kinase C alpha and delta in testes of mouse at various stages of developmentChen Feng
Department of Biochemistry, China Medical University, Shenyang, Liaoning Province, PRC
Cell Biochem Funct 23:415-20. 2005..The results suggest that each isoenzyme may have different functional roles in processing and modulating physiological cellular responses of spermatogenesis...
- Modulation of mitochondrial metabolic function by phorbol 12-myristate 13-acetate through increased mitochondrial translocation of protein kinase Calpha in C2C12 myocytesYing Wang
Laboratories of Biochemistry, Department of Animal Biology and the Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Biochem Pharmacol 72:881-92. 2006..All of these changes could be retarded by treatment with PKC inhibitors. These results show a direct role for PMA-mediated PKCalpha translocation to mitochondria in inducing mitochondrial toxicity...
- Oxygen deprivation triggers upregulation of early growth response-1 by the receptor for advanced glycation end productsJong Sun Chang
Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY 10032, USA
Circ Res 102:905-13. 2008..These findings identify RAGE as a master regulator of tissue stress elicited by hypoxia and highlight this receptor as a central therapeutic target to suppress the tissue injury-provoking effects of oxygen deprivation...
- Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2Xiuqian Mu
Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center and Graduate Training Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA
Proc Natl Acad Sci U S A 105:6942-7. 2008..They also reveal that identical RGC expression patterns are achieved by different combinations of divergent inputs from upstream transcription factors...
- Intrathecal administration of sigma-1 receptor agonists facilitates nociception: involvement of a protein kinase C-dependent pathwayDae Hyun Roh
Department of Veterinary Physiology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, South Korea
J Neurosci Res 86:3644-54. 2008..Collectively, these findings demonstrate that calcium-dependent second messenger cascades including PKC are involved in the facilitation of nociception associated with spinal sigma-1 receptor activation...
- Modulation of Ca(2+) release through ryanodine receptors in vascular smooth muscle by protein kinase CalphaHongli Peng
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
Pflugers Arch 460:791-802. 2010..In conclusion, our studies suggest that PKC activation can inhibit the gating activity of RyRs in the SR of ASMCs, and this regulation is most likely mediated by the Ca(2+)-dependent PKCalpha isoform...
- Epicardial spindle orientation controls cell entry into the myocardiumMingfu Wu
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Dev Cell 19:114-25. 2010..Taken together, these data suggest that directed mitotic spindle orientation contributes to epicardial EMT and implicate a junctional complex of beta-catenin and Numb in the regulation of spindle orientation...
- Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophagesHongtao Guo
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 285:37787-96. 2010..We conclude that OPN and PDLIM2 are important regulators of STAT1-mediated inflammatory responses...
- Protein kinase Cα activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscleMartin Thomassen
Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
Am J Physiol Regul Integr Comp Physiol 301:R1808-14. 2011..In conclusion, exercise induces FXYD1 phosphorylation at multiple sites in human skeletal muscle. In mouse muscles, contraction-induced changes in FXYD1 ser68 phosphorylation are fiber-type specific and dependent on PKCα activity...
- Direct evidence that PKCα positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesivenessHelen A Thomason
Faculty of Life Sciences, University of Manchester, UK
J Pathol 227:346-56. 2012..These results throw new mechanistic light on the earliest stages of wound re-epithelialization and suggest activation of PKCα as a new therapeutic strategy for non-healing wounds...
- Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampusA Mogha
Doctoral Program in Biology, City University of New York, NY, USA
Transl Psychiatry 2:e66. 2012..The elucidated signaling cascade explains how 5-HT(1A)-R regulates hippocampal sculpting and function, which may determine the affective phenotype of an adult...
- The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in miceGiselle F Passos
Department of Pharmacology, Universidade Federal de Santa Catarina, 88040 900 Florianopolis, Santa Catarina, Brazil
Eur J Pharmacol 698:413-20. 2013..Our data indicate that topical application of euphol markedly inhibits the inflammatory response induced by TPA. Thus, euphol represents a promising agent for the management of skin diseases with an inflammatory component...
- De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarityZhufeng Yang
Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Development 140:1774-84. 2013....
- Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiationChanchao Lorthongpanich
Mammalian Development Laboratory, Institute of Medical Biology, Singapore
Genes Dev 27:1441-6. 2013..We therefore conclude that precisely timed YAP localization in early morulae is essential to prevent trophectoderm marker expression in, and lineage specification of, the ICM. ..
- Onecut1 is essential for horizontal cell genesis and retinal integrityFuguo Wu
Department of Ophthalmology Ross Eye Institute and Developmental Genomics Group, New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York 14203, USA
J Neurosci 33:13053-65, 13065a. 2013..In sum, these results demonstrate that Oc1 is a critical determinant of HC fate, and reveal that HCs are essential for photoreceptor viability, retinal integrity, and normal visual function. ..
- ENaC activity and expression is decreased in the lungs of protein kinase C-α knockout miceAmity F Eaton
Department of Physiology and the Center for Cell and Molecular Signaling, Emory University School of Medicine, Atlanta, Georgia
Am J Physiol Lung Cell Mol Physiol 307:L374-85. 2014..These results explain the decrease in ENaC activity in PKC-α knockout lung. ..
- Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytesRinako Nakagawa
Institute of Cancer Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow The Babraham Institute, Cambridge
Haematologica 100:499-510. 2015..We previously established that stable expression of kinase dead protein kinase C alpha in hematopoietic progenitor cells resulted in the development of a chronic lymphocytic leukemia-like ..
- Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase Cα in CardiomyocytesYogananda S Markandeya
From the Cellular and Molecular Arrhythmia Research Program, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53706
J Biol Chem 290:22085-100. 2015..In conclusion, we show that stable Cav-3 expression is essential for protecting the signaling mechanisms in pharmacologically and pressure overload-induced cardiac hypertrophy. ..
- PKC-α-dependent augmentation of cAMP and CREB phosphorylation mediates the angiotensin II stimulation of renin in the collecting ductAlexis A Gonzalez
Instituto de Quimica, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana and
Am J Physiol Renal Physiol 309:F880-8. 2015..This study defines the intracellular signaling pathway involved in the ANG II-mediated stimulation of renin in the CD. This is a novel mechanism responsible for the regulation of local renin-angiotensin system in the distal nephron...
- The expression and function of netrin-4 in murine ocular tissuesYong N Li
Graduate Program in Molecular Cellular and Developmental Biology, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, MA 02111, USA
Exp Eye Res 96:24-35. 2012..Ntn4-/- mice may serve as a good model in which to study the role of netrins in vivo of the pathobiologic vascular remodeling in the retina and cornea...
- Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting ductJanet D Klein
Emory University School of Medicine, Department of Medicine, Renal Division, 1639 Pierce Dr, Atlanta, GA 30322, USA
Am J Physiol Renal Physiol 302:F1098-103. 2012..Hypertonicity significantly increased UT-A1 phosphorylation in wild-type mice but not in PKC-α knockout mice. We conclude that PKC-α mediates the hypertonicity-stimulated increase in UT-A1 phosphorylation in the IMCD...
- PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrityEmily Vandenbroucke St Amant
Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois College of Medicine, 835 S Wolcott Ave, M C 86, Chicago, IL 60612, USA
Circ Res 111:739-49. 2012..p120 dissociation from VE-cadherin results in loss of VE-cadherin homotypic interaction and AJ disassembly; however, the signaling mechanisms regulating p120 dissociation from VE-cadherin are not understood...
- Reactive cysteine in the structural Zn(2+) site of the C1B domain from PKCαMikaela D Stewart
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 2128, United States
Biochemistry 51:7263-77. 2012..Our data suggest that Cys151 serves as an entry point for the reactive oxygen species that activate PKCα in a process involving Zn(2+) release...
- Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retinaAmel Kechad
Cellular Neurobiology Research Unit, Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
J Neurosci 32:17197-210. 2012....
- Low molecular weight fibroblast growth factor-2 signals via protein kinase C and myofibrillar proteins to protect against postischemic cardiac dysfunctionJanet R Manning
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Am J Physiol Heart Circ Physiol 304:H1382-96. 2013....
- A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and humanA M Buchberg
Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
Genetics 122:153-61. 1989..analysis were determined (Erbb, Rel, 11-3, Csfgm, Trp53-1, Evi-2, Erba, Erbb-2, Csfg, Myhs, Cola-1, Myla, Hox-2 and Pkca)...
- Cell type-specific expression of the genes for the protein kinase C family: down regulation of mRNAs for PKC alpha and nPKC epsilon upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2aH Wada
Department of Molecular Biology, Tokyo Metropolitan Institute of Medical Science, Japan
Biochem Biophys Res Commun 165:533-8. 1989..Human lymphoid cell lines express large amounts of PKC beta mRNAs in addition to PKC alpha. Further, nPKC epsilon mRNA is expressed in some of these cell lines...
- Sequence and localization of a novel FK506-binding protein to mouse chromosome 11S L Simek
Biological Carcinogenesis and Development Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland
Genomics 18:407-9. 1993..We have localized the FKBPRP gene to mouse Chromosome 11, and crosses of different murine strains provided the gene order centromere--FKBPRP-Int-4-Pkca-Es-3.
- Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alphaA A Dlugosz
Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, Maryland 20892
Cancer Res 54:6413-20. 1994....
- Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data baseS Tugendreich
Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205
Proc Natl Acad Sci U S A 90:10031-5. 1993..cerevisiae CDC27 has been identified and mapped to human chromosome 17 and mouse chromosome 11 between the Pkca and Erbb-2 genes...
- Mouse galactokinase: isolation, characterization, and location on chromosome 11Y Ai
Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia 19104, USA
Genome Res 5:53-9. 1995..The availability of the mouse gene provides an opportunity to make a knockout model for galactokinase deficiency...
- Developmental expression of MARCKS and protein kinase C in mice in relation to the exencephaly resulting from MARCKS deficiencyP J Blackshear
Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA
Brain Res Dev Brain Res 96:62-75. 1996..5-9.5. MARCKS and PKC alpha were expressed at the plasma membrane of the neuroepithelial cells comprising the future neural tube, as well as ..
- Gene structure and chromosomal localization of the mouse NMDA receptor channel subunitsM Nagasawa
Department of Neuropharmacology, Niigata University, Japan
Brain Res Mol Brain Res 36:1-11. 1996..Each of these genes mapped to a single chromosome location. The mapping results assigned the five loci to five different mouse autosomes, indicating that they have become well dispersed among mouse chromosomes...
- Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21I Bergstein
Strang Cornell Cancer Research Laboratory, Cornell University Medical College, New York, New York 10021, USA
Genomics 46:450-8. 1997..We show that human WNT14 maps to chromosome 1 and that WNT15 maps distal to BRCA1 on chromosome 17q21, where it lies within 125 kb of another WNT family member, WNT3...
- Cloning and characterization of the murine PKC alpha promoter: identification of a retinoic acid response elementD S Desai
Department of Molecular Biology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, Yokohama, 236, Japan
Biochem Biophys Res Commun 263:28-34. 1999..We have previously demonstrated that levels of PKC alpha mRNA, protein, and enzyme activity in B16 melanoma cells can be modulated by retinoic acid...
- Overexpression of protein kinase C-alpha in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-alpha expression but not tumor promotionH Q Wang
Molecular and Cellular Toxicology, Department of Toxicology, North Carolina State University, Raleigh, NC 27695 7633, USA
J Cell Sci 112:3497-506. 1999....
- Quantitative trait locus mapping of genes regulating pulmonary PKC activity and PKC-alpha contentL D Dwyer-Nield
Department of Pharmaceutical Sciences and University of Colorado Cancer Center, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Am J Physiol Lung Cell Mol Physiol 279:L326-32. 2000..4). The chromosome 11 QTL responsible for low PKC-alpha content falls within QTLs for susceptibilities to lung tumorigenesis and ozone-induced toxicity...
- Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factorYuji Saito
Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 277:23216-22. 2002..Because PDGF-mediated ERK activation is enhanced in Chinese hamster ovary cells that overexpress Gab1, Gab1 serves as an important link between PKC and ERK activation by PDGFbeta receptors in VSMC...
- Inhibition of glycogen synthesis by fatty acid in C(2)C(12) muscle cells is independent of PKC-alpha, -epsilon, and -thetaR Cazzolli
Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
Am J Physiol Endocrinol Metab 282:E1204-13. 2002..We conclude that neither mitochondrial lipid metabolism nor activation of PKC-alpha, -epsilon, or -theta plays a role in the direct inhibition of glycogen synthesis by unsaturated fatty acids...
- PICK1, an anchoring protein that specifically targets protein kinase Calpha to mitochondria selectively upon serum stimulation in NIH 3T3 cellsWei Li Wang
Department of Biochemistry, National Yang Ming University, Taipei, 112, Taiwan
J Biol Chem 278:37705-12. 2003..These findings indicate a previously unidentified role for PICK1 in anchoring PKCalpha to mitochondria in a ligand-specific manner...
- Protein kinase C activity regulates the onset of anaphase I in mouse oocytesMaria M Viveiros
Center for Animal Transgenesis and Germ Cell Research, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA
Biol Reprod 71:1525-32. 2004..Similarly, failure to regulate PKC activity at the preovulatory stage likely promotes arrest at MI...
- Depolarization of skeletal muscle cells induces phosphorylation of cAMP response element binding protein via calcium and protein kinase CalphaCesar Cardenas
Centro de Estudios Moleculares de la Célula, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago 7, Chile
J Biol Chem 279:39122-31. 2004..These results strongly implicate nuclear PKCalpha translocation in CREB phosphorylation induced by skeletal muscle membrane depolarization...
- The transcription factor Bhlhb4 is required for rod bipolar cell maturationDebra E Bramblett
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Neuron 43:779-93. 2004..Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation...
- Activation-induced depletion of protein kinase C alpha provokes desensitization of monocytes/macrophages in sepsisAndreas von Knethen
Department of Cell Biology, University Kaiserslautern, Kaiserslautern, Germany
J Immunol 174:4960-5. 2005..Inhibition of the oxidative burst and depletion of protein kinase C alpha (PKC alpha) were correlated in septic patients...
- Effect of p75NTR on the regulation of naturally occurring cell death and retinal ganglion cell number in the mouse eyeChikako Harada
Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
Dev Biol 290:57-65. 2006..These results suggest the different mechanism of RGC number control between mouse and chick retina...
- Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathwaysGuiming Li
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
Cell Immunol 238:10-8. 2005..Since MAPK modules differentially regulate mast cell functions, including degranulation and cytokine production, it is suggested that specific functions could be targeted by inhibiting specific PKC isoforms...
- Protein kinase Calpha can undergo membrane localization via an alternative phosphatidylinositol 4,5-bisphosphate-dependent pathwayHyowon Son
Department of Life Sciences, Division of Molecular Life Sciences and Center for Cell Signaling Research, Ewha Womans University, Daehyun dong, Seodaemoon Gu, Seoul, Republic of Korea
Arch Biochem Biophys 454:1-6. 2006..Finally, we found that PIP2 is involved in syndecan-4-mediated membrane localization of PKCalpha. Taken together, these data suggest that PIP2 might contribute to directly regulating the membrane localization of PKCalpha...
- Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinityJohn A Corbin
Molecular Biophysics Program, and Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309 0215, USA
Biochemistry 46:4322-36. 2007....
- Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failureMichael Hambleton
Division of Molecular Cardiovascular Biology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Am J Physiol Heart Circ Physiol 293:H3768-71. 2007Mice null for the gene encoding protein kinase Calpha (Prkca), or mice treated with pharmacologic inhibitors of the PKCalpha/beta/gamma isoforms, show an augmentation in cardiac contractility that appears to be cardioprotective...
- Role of protein kinase C in selective inhibition of mouse retinal neurites during contacts with chondroitin sulfatesJoyce Shi Ying Lam
Department of Anatomy, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
Neurosci Lett 434:150-4. 2008....
- Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signallingTsuneo Ikenoue
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA
EMBO J 27:1919-31. 2008..Our study demonstrates that mTORC2 is involved in post-translational processing of PKC by facilitating TM and HM phosphorylation and reveals a novel function of mTORC2 in cellular regulation...
- The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKCL Ren
Tumor and Metastasis Biology Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
Oncogene 28:792-802. 2009..These data are the first to suggest a dynamic regulation of ezrin phosphorylation during metastasis and to connect the PKC family members with this regulation...
- [Effect of phenethyl isothiocyanate on expression of genes during differentiation process of mouse embryonic stem cells in vitro]Zhou Yu
Institute of Nutrition and Food Safety, China CDC, Beijing
Wei Sheng Yan Jiu 37:693-6. 2008To study the effect of phenethyl isothiocyanate on the expression of protein kinase C alpha and the developmental genes (pax-6 and netrin-1) during differentiation process of mouse embryonic stem cells into neuron-like cells in vitro.
- REGULATION OF SODIUM TRANSPORT IN TIGHT EPITHELIADouglas Eaton; Fiscal Year: 2001..questions will be answered is there any difference in the action of insulin and IGF-1 on A6 cells? Which Na channel subunits are tyrosine phosphorylated by IGF-1? Are there effects of tyrosine kinases in the absence of insulin or IGF-1? ..
- INTERACTION OF CFTR AND EPITHELIAL NA CHANNELSDouglas Eaton; Fiscal Year: 2003..These studies will provide new information about mechanisms of coordinate regulation of epithelial Na and C1 transport. ..
- FUNCTION AND MODULATION OF METABOTROPIC GLU RECEPTOR 5ROBERT GEREAU; Fiscal Year: 2003..These studies will help identify the specific functions and mechanism of modulation of mGlu5 in hippocampus. ..
- Center for Development of Biological Nanosensors (RMI)Douglas Eaton; Fiscal Year: 2004..This knowledge may lead to better understanding and new strategies for treatment of disorders specifically related to cell communication crocesses like diabetes, cystic fibrosis in the lung, and polycystic kidney disease...
- ENaC ASSEMBLY, TRAFFICKING AND DEGRADATION IN LUNGDouglas Eaton; Fiscal Year: 2006..abstract_text> ..
- Midwest Regional Pain Interest Group MeetingROBERT GEREAU; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- AMYGDALA PLASTICITY IN PAINROBERT GEREAU; Fiscal Year: 2008..These studies will lay important groundwork for future investigations of the[unreadable] importance of amygdala ERK signaling in pain sensitization. ..
- BHLH FACTOR IN DIABETES & PANCREAS DEVELOPMENTDEBRA BRAMBLETT; Fiscal Year: 2003..The BETA4 knockout will be a mouse model system for the study of aspects of pancreas development and possibly pancreatic disease. ..
- Regulation and Function of C/EBP in UVB ResponsesRobert C Smart; Fiscal Year: 2010..abstract_text> ..