Prkaa1

Summary

Gene Symbol: Prkaa1
Description: protein kinase, AMP-activated, alpha 1 catalytic subunit
Alias: AI194361, AI450832, AL024255, AMPKalpha1, C130083N04Rik, 5'-AMP-activated protein kinase catalytic subunit alpha-1, ACACA kinase, AMP-activated protein kinase, alpha 1 catalytic subunit, AMPK subunit alpha-1, HMGCR kinase, acetyl-CoA carboxylase kinase, hydroxymethylglutaryl-CoA reductase kinase, tau-protein kinase PRKAA1
Species: mouse

Top Publications

  1. pmc Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    Duygu Sag
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 181:8633-41. 2008
  2. pmc Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo
    G Sun
    Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, SW7 2AZ, UK
    Diabetologia 53:924-36. 2010
  3. doi The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation
    Emma Barroso
    Department of Pharmacology and Therapeutic Chemistry, and Institut de Biomedicina de la University of Barcelona, Barcelona Spain
    Endocrinology 152:1848-59. 2011
  4. pmc Compound C inhibits hypoxic activation of HIF-1 independent of AMPK
    Brooke M Emerling
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    FEBS Lett 581:5727-31. 2007
  5. pmc Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response
    Astrid Spruss
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Mol Med 18:1346-55. 2012
  6. pmc AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation
    Junyu Ning
    Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27705, USA
    Mol Endocrinol 24:1218-29. 2010
  7. ncbi Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1
    Changhua Wang
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 282:7991-6. 2007
  8. pmc Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression
    Jolene Bohensky
    Department of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Pediatr Nephrol 25:633-42. 2010
  9. pmc Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
    Fanny Pilot-Storck
    UMR5239 Laboratoire de Biologie Moléculaire de la Cellule, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Cell Proteomics 9:1578-93. 2010
  10. ncbi Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system
    A M Turnley
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    J Neurochem 72:1707-16. 1999

Research Grants

  1. Mitochondrial Regulation of Hyperoxic Cell Death
    GR BUDINGER; Fiscal Year: 2005
  2. FORMAL METHODS APPLIED TO BIOLOGICAL SIGNALING NETWORKS
    Keith Laderoute; Fiscal Year: 2006
  3. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
  4. HYPOXIC STRESS MECHANISMS IN RADIATION AND CHEMOTHERAPY
    Keith Laderoute; Fiscal Year: 2009
  5. ROLE OF AMPK IN TUMOR DEVELOPMENT AND THERAPY
    Keith R Laderoute; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications131 found, 100 shown here

  1. pmc Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype
    Duygu Sag
    Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, KY 40292, USA
    J Immunol 181:8633-41. 2008
    ..Likewise, expression of a dominant negative AMPKalpha1 in macrophages enhanced TNF-alpha and IL-6 protein synthesis in response to LPS stimulation, while diminishing ..
  2. pmc Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo
    G Sun
    Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, Sir Alexander Fleming Building, Exhibition Road, South Kensington, London, SW7 2AZ, UK
    Diabetologia 53:924-36. 2010
    ..AMP-activated protein kinase (AMPK) is an evolutionarily conserved enzyme and a target of glucose-lowering agents, including metformin. However, the precise role or roles of the enzyme in controlling insulin secretion remain uncertain...
  3. doi The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation
    Emma Barroso
    Department of Pharmacology and Therapeutic Chemistry, and Institut de Biomedicina de la University of Barcelona, Barcelona Spain
    Endocrinology 152:1848-59. 2011
    ..These findings indicate that the hypotriglyceridemic effect of GW501516 in HFD-fed mice is accompanied by an increase in phospho-AMPK levels and the amplification of the PGC-1α-lipin 1-PPARα pathway...
  4. pmc Compound C inhibits hypoxic activation of HIF-1 independent of AMPK
    Brooke M Emerling
    Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    FEBS Lett 581:5727-31. 2007
    ..Furthermore, we demonstrate that Compound C functions as a repressor of HIF-1 by inhibiting respiration and suppressing mitochondrial generated ROS...
  5. pmc Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response
    Astrid Spruss
    Department of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany
    Mol Med 18:1346-55. 2012
    ..In conclusion, our data suggest that the sex-specific differences in the susceptibility to NAFLD are associated with differences in the regulation of the adiponectin-AMPK-PAI-1 signaling cascade...
  6. pmc AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation
    Junyu Ning
    Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 27705, USA
    Mol Endocrinol 24:1218-29. 2010
    ..Because IGF-I is an important stimulant of the anabolic response, this effect of AMPK could account for part of its inhibitory effect on protein synthesis, thus allowing more efficient energy use by other cellular processes...
  7. ncbi Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1
    Changhua Wang
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 282:7991-6. 2007
    ..These results indicate that activation of the LKB1/AMPK/TSC1/2 pathway alleviates the p70 S6 kinase-mediated negative regulation of insulin signaling, providing a mechanism by which adiponectin increases insulin sensitivity in cells...
  8. pmc Chondrocyte autophagy is stimulated by HIF-1 dependent AMPK activation and mTOR suppression
    Jolene Bohensky
    Department of Orthopedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Pediatr Nephrol 25:633-42. 2010
    ..Based on these findings, it is concluded that because of the micro-environmental changes experienced by the chondrocyte, autophagy is activated by AMPK in a HIF-1-dependent manner...
  9. pmc Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
    Fanny Pilot-Storck
    UMR5239 Laboratoire de Biologie Moléculaire de la Cellule, Ecole Normale Superieure de Lyon, Lyon, France
    Mol Cell Proteomics 9:1578-93. 2010
    ..We propose that DEAF1 may represent a therapeutic target of lithium and other GSK3 inhibitors used in bipolar disease and depression...
  10. ncbi Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system
    A M Turnley
    The Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    J Neurochem 72:1707-16. 1999
    ....
  11. ncbi Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models
    B Viollet
    Institut Cochin, Dpt GDPM, 24 Rue du Faubourg Saint Jacques 75014 Paris, France
    Biochem Soc Trans 31:216-9. 2003
    ..We suggest that the alpha2 catalytic subunit of AMPK plays a major role as a fuel sensor by modulating the activity of the autonomous nervous system in vivo...
  12. ncbi Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 279:1070-9. 2004
    ..Alternatively, neither alpha-isoform of AMPK is involved in contraction-induced muscle glucose uptake...
  13. pmc The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    Reuben J Shaw
    Department of Systems Biology, Harvard Medical School, and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:3329-35. 2004
    ..The role of LKB1/AMPK in the survival of a subset of genetically defined tumor cells may provide opportunities for cancer therapeutics...
  14. pmc AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
    Raymond R Russell
    Department of Internal Medicine Section of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Clin Invest 114:495-503. 2004
    ..Thus, AMPK is responsible for activation of glucose uptake and glycolysis during low-flow ischemia and plays an important protective role in limiting damage and apoptotic activity associated with ischemia and reperfusion in the heart...
  15. ncbi Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes
    Marie Daval
    INSERM U671, Centre de Recherches Biomedicales des Cordeliers, Universite Pierre et Marie Curie, 75270 Paris Cedex 06, France
    J Biol Chem 280:25250-7. 2005
    ..We conclude that, in mature adipocytes, AMP-activated protein kinase activation has a clear anti-lipolytic effect...
  16. ncbi Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase
    Simon A Hawley
    Division of Molecular Physiology University of Dundee, Dundee, Scotland, United Kingdom
    Cell Metab 2:9-19. 2005
    ..Our results suggest a potential Ca(2+)-dependent neuroprotective pathway involving phosphorylation and activation of AMPK by CaMKKbeta...
  17. pmc The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    Reuben J Shaw
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 310:1642-6. 2005
    ..Finally, we show that metformin, one of the most widely prescribed type 2 diabetes therapeutics, requires LKB1 in the liver to lower blood glucose levels...
  18. ncbi 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and metformin inhibit hepatic glucose phosphorylation by an AMP-activated protein kinase-independent effect on glucokinase translocation
    Bruno Guigas
    Hormone and Metabolic Research Unit, Institute of Cellular Pathology, UCL 7529, Avenue Hippocrate 75, 1200 Brussels, Belgium
    Diabetes 55:865-74. 2006
    ....
  19. pmc 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments
    Keith R Laderoute
    SRI International, Bldg L, Rm A258, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Mol Cell Biol 26:5336-47. 2006
    ..We also showed that AMPK is important for the growth of this tumor model...
  20. ncbi Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP
    Rebecca L Hurley
    Department of Medicine and Biochemistry, Dartmouth Medical School, Remsen 322, N College St, Hanover, NH 03755, USA
    J Biol Chem 281:36662-72. 2006
    ....
  21. ncbi Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2
    Jee Hyun Um
    Laboratory of Biochemical Genetics, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:20794-8. 2007
    ..We conclude that metformin and AMPK have a previously unrecognized role in regulating the circadian rhythm...
  22. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007
    ....
  23. ncbi Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase
    Ken Shinmura
    Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan 160 8582
    Circulation 116:2809-17. 2007
    ..We have demonstrated that short-term CR improves myocardial ischemic tolerance and increases adiponectin levels. Here, we investigated the specific role of adiponectin in CR-induced cardioprotection...
  24. pmc Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    Aram F Hezel
    MGH Cancer Center, Simches Research Building, CPZN 4216, 185 Cambridge St, Boston, MA 02114, USA
    Mol Cell Biol 28:2414-25. 2008
    ..These genetic studies provide in vivo evidence of a key role for LKB1 in the establishment of epithelial cell polarity that is vital for pancreatic acinar cell function and viability and for the suppression of neoplasia...
  25. doi AMP-activated protein kinase regulates lymphocyte responses to metabolic stress but is largely dispensable for immune cell development and function
    Alice Mayer
    Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, Gosselies, Belgium
    Eur J Immunol 38:948-56. 2008
    ..Taking advantage of the selective expression of the AMPKalpha1 catalytic subunit in lymphoid cells, we have analyzed the in vitro and in vivo capacity of lymphocytes lacking ..
  26. doi Lkb1 deficiency causes prostate neoplasia in the mouse
    Helen B Pearson
    Cardiff University, School of Biosciences, Cardiff, Wales, United Kingdom
    Cancer Res 68:2223-32. 2008
    ..For the first time, this model establishes a link between the tumor suppressor Lkb1 and prostate neoplasia, highlighting a tumor suppressive role within the mouse and raising the possibility of a similar association in the human...
  27. pmc AMPK phosphorylation of raptor mediates a metabolic checkpoint
    Dana M Gwinn
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 30:214-26. 2008
    ..These findings uncover a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status...
  28. pmc AMPK and PPARdelta agonists are exercise mimetics
    Vihang A Narkar
    Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Cell 134:405-15. 2008
    ..These results demonstrate that AMPK-PPARdelta pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance without exercise...
  29. doi Metformin enhances the differentiation and mineralization of osteoblastic MC3T3-E1 cells via AMP kinase activation as well as eNOS and BMP-2 expression
    Ippei Kanazawa
    Department of Internal Medicine 1, Shimane University Faculty of Medicine, 89 1 Enya cho, Izumo 693 8501, Japan
    Biochem Biophys Res Commun 375:414-9. 2008
    ....
  30. pmc AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Carles Canto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Nature 458:1056-60. 2009
    ..The AMPK-induced SIRT1-mediated deacetylation of these targets explains many of the convergent biological effects of AMPK and SIRT1 on energy metabolism...
  31. pmc AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation
    Katja A Lamia
    Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Science 326:437-40. 2009
    ..Thus, phosphorylation by AMPK enables cryptochrome to transduce nutrient signals to circadian clocks in mammalian peripheral organs...
  32. pmc Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
    Carles Canto
    Ecole Polytechnique Federale de Lausanne, Switzerland
    Cell Metab 11:213-9. 2010
    ....
  33. pmc Activation of AMP-activated protein kinase alpha1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and survivin
    Chao Liu
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 285:15346-55. 2010
    ..Finally, we found that genetic deletion of the AMPKalpha1, but not AMPKalpha2, suppressed OGD-enhanced NF-kappaB activation, the expression of Bcl-2 and Survivin, and ..
  34. pmc AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass
    M Shah
    Department of Veterinary Basic Sciences Royal Veterinary College, Royal College Street, London, NW1 OTU, UK
    Bone 47:309-19. 2010
    ..RT-PCR analysis of AMPK subunits in ROS17/2.8 osteoblastic cells and in mouse tibia showed that the AMPKalpha1 subunit is the dominant isoform expressed in bone...
  35. pmc Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    Marc Foretz
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 120:2355-69. 2010
    ..In conclusion, we demonstrate that metformin inhibits hepatic gluconeogenesis in an LKB1- and AMPK-independent manner via a decrease in hepatic energy state...
  36. pmc Identification of a nuclear export signal in the catalytic subunit of AMP-activated protein kinase
    Nevzat Kazgan
    Neuroscience Center, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599 7250, USA
    Mol Biol Cell 21:3433-42. 2010
    ..Thus, modulation of CRM1-mediated export of AMPKα via its C-terminal NES provides an additional mechanism for cells to use in the regulation of AMPK activity and localization...
  37. doi AMP kinase acts as a negative regulator of RANKL in the differentiation of osteoclasts
    Young Sun Lee
    Asan Institute for Life Sciences, Seoul 138 736, Republic of Korea
    Bone 47:926-37. 2010
    ..AMP-activated protein kinase (AMPK) has been reported to stimulate differentiation and proliferation of osteoblasts, but the role of AMPK in the physiology of osteoclasts has not been investigated...
  38. pmc Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK
    Andrew G Edwards
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Mech Ageing Dev 131:739-42. 2010
    ..18±0.03 vs. LCR, 2.39±0.08 ratio, p<0.05). These results indicate that life-long caloric restriction profoundly protects the aged heart against I/R injury, and suggest that AMPK may play a role in that protection...
  39. pmc Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    Daisuke Nakada
    Howard Hughes Medical Institute, Life Sciences Institute, Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 468:653-8. 2010
    ..Lkb1 is therefore required for HSC maintenance through AMPK-dependent and AMPK-independent mechanisms, revealing differences in metabolic and cell-cycle regulation between HSCs and some other haematopoietic progenitors...
  40. doi AMP-activated protein kinase (AMPK) positively regulates osteoblast differentiation via induction of Dlx5-dependent Runx2 expression in MC3T3E1 cells
    Won Gu Jang
    Department of Pharmacology and Dental Therapeutics and BK21, School of Dentistry, Chonnam National University, Gwangju 500 757, Republic of Korea
    Biochem Biophys Res Commun 404:1004-9. 2011
    ..These results suggest that the activation of AMPK stimulates osteoblast differentiation via the regulation of Smad1/5/8-Dlx5-Runx2 signaling pathway...
  41. pmc Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    Daniel F Egan
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 331:456-61. 2011
    ..These findings uncover a conserved biochemical mechanism coupling nutrient status with autophagy and cell survival...
  42. pmc AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    Joungmok Kim
    Department of Pharmacology and Moores Cancer Center, University of California at San Diego, La Jolla, CA 92130, USA
    Nat Cell Biol 13:132-41. 2011
    ..This coordinated phosphorylation is important for Ulk1 in autophagy induction. Our study has revealed a signalling mechanism for Ulk1 regulation and autophagy induction in response to nutrient signalling...
  43. pmc AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    Yu Li
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02481, USA
    Cell Metab 13:376-88. 2011
    ..AMPK-dependent phosphorylation of SREBP may offer therapeutic strategies to combat insulin resistance, dyslipidemia, and atherosclerosis...
  44. pmc AMPKα2 deletion exacerbates neointima formation by upregulating Skp2 in vascular smooth muscle cells
    Ping Song
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Circ Res 109:1230-9. 2011
    ..Whether AMPKα alters vascular neointima formation induced by vascular injury is unknown...
  45. doi Inactivation of AMPKα1 induces asthenozoospermia and alters spermatozoa morphology
    Pauline Tartarin
    Unité Mixte de Recherche UMR 6175, Physiologie de la Reproduction et des Comportements Institut National dela Recherche Agronomique Centre National dela Recherche Scientifique Université Tours Haras Nationaux, 37380 Nouzilly, France
    Endocrinology 153:3468-81. 2012
    ..These results suggest that total α1AMPK deficiency in male mice affects androgen production and quality of spermatozoa, leading to a decrease in fertility...
  46. pmc AMP-activated protein kinase α1 but not α2 catalytic subunit potentiates myogenin expression and myogenesis
    Xing Fu
    Department of Animal Sciences, Washington State University, Pullman, Washington, USA
    Mol Cell Biol 33:4517-25. 2013
    ..In summary, these results indicate that AMPK activity promotes myogenesis through a mechanism mediated by AMPKα1. ..
  47. ncbi 5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics
    Takashi Tsuboi
    Henry Wellcome Laboratories for Integrated Cell Signalling and Department of Biochemistry, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 278:52042-51. 2003
    ..Overexpression of a truncated, constitutively active form of AMPK (AMPKalpha1, 1-312, T172D; AMPK CA), inhibited glucose-stimulated (30 versus 3...
  48. pmc AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside
    Bruno Guigas
    Université catholique de Louvain and Institute of Cellular Pathology, Hormone and Metabolic Research Unit, Brussels, Belgium
    Biochem J 404:499-507. 2007
    ..Our data also demonstrate that the cellular effects of AICA riboside are not necessarily caused by AMPK activation and that their interpretation should be taken with caution...
  49. pmc Resveratrol stimulates AMP kinase activity in neurons
    Biplab Dasgupta
    Departments of Pathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:7217-22. 2007
    ..These findings suggest that neuronal activation of AMPK by resveratrol could affect neuronal energy homeostasis and contribute to the neuroprotective effects of resveratrol...
  50. pmc Activation of AMP-activated protein kinase in cerebella of Atm-/- mice is attributable to accumulation of reactive oxygen species
    Xianghong Kuang
    Department of Molecular Carcinogenesis, The University of Texas, MD Anderson Cancer Center, Smithville, TX 78957, United States
    Biochem Biophys Res Commun 418:267-72. 2012
    ....
  51. pmc Leptin activates hepatic 5'-AMP-activated protein kinase through sympathetic nervous system and α1-adrenergic receptor: a potential mechanism for improvement of fatty liver in lipodystrophy by leptin
    Licht Miyamoto
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto University Hospital, 54 Shogoin Kawahara cho, Kyoto 606 8507, Japan
    J Biol Chem 287:40441-7. 2012
    ..AMPK activation promotes glucose and lipid metabolism...
  52. doi Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway
    Soon Hee Kim
    Nutrition and Metabolism Research Group, Korea Food Research Institute, Gyeonggi do 463 746, Republic of Korea
    Biochem Biophys Res Commun 439:66-70. 2013
    ..Taken together, these results suggest that capsaicin, independent of insulin, increases glucose uptake via ROS generation and consequent AMPK and p38 MAPK activations...
  53. doi AMPK activation regulates neuronal structure in developing hippocampal neurons
    S Ramamurthy
    Department of Neuroscience, Johns Hopkins University School of Medicine, 855 N Wolfe Street, Baltimore, MD 21205, USA Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, 855 N Wolfe Street, Baltimore, MD 21205, USA
    Neuroscience 259:13-24. 2014
    ..These findings demonstrate that the energy-sensing AMPK pathway regulates neuronal structure in distinct regions of developing neurons at multiple stages of development. ..
  54. pmc Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models
    Nirma D Perera
    Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Melbourne, Victoria, Australia Centre for Neuroscience, University of Melbourne, Parkville, Melbourne, Victoria, Australia
    PLoS ONE 9:e90449. 2014
    ..While AMPK activation in motor neurons correlateswith progressionin mutant SOD1-mediated disease, AMPK inactivation mediated by PP2Ais associated withmutant TDP-43-linked ALS. ..
  55. pmc Crude extracts from Lycium barbarum suppress SREBP-1c expression and prevent diet-induced fatty liver through AMPK activation
    Wang Li
    Biochemistry and Molecular Biology, Ningxia Medical University, Yinchuan 750004, China
    Biomed Res Int 2014:196198. 2014
    ..In summary, LBP possesses a potential novel treatment in preventing diet-induced fatty liver. ..
  56. pmc Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium
    Huiqing Zeng
    Department of Biology, Eberly College of Science, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 5:e15900. 2010
    ..Finally, we show that ciliary localization of Sufu is dependent on ciliary-localized Gli proteins, and is inhibited by PKA activation, suggesting a coordinated mechanism for the ciliary translocation of Sufu and Gli proteins...
  57. doi Cardiotrophin-1 is a key regulator of glucose and lipid metabolism
    Maria J Moreno-Aliaga
    Department of Nutrition, Food Sciences, Physiology and Toxicology, University of Navarra, 31008 Pamplona, Spain
    Cell Metab 14:242-53. 2011
    ..We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin resistance...
  58. doi AMPK alpha 1-induced RhoA phosphorylation mediates vasoprotective effect of estradiol
    Marion Gayard
    Institut National de la Sante et de la Recherche Medicale, UMR915, Institut du Thorax, Nantes, France
    Arterioscler Thromb Vasc Biol 31:2634-42. 2011
    ..As evidence accumulates regarding the role of RhoA in vascular pathophysiology and the benefit of RhoA-Rho associated protein kinase (Rock) pathway inhibition, we analyzed if E2 could inhibit it in VSMC...
  59. pmc Prostaglandin E2 promotes endothelial differentiation from bone marrow-derived cells through AMPK activation
    Zhenjiu Zhu
    Key Laboratory of Molecular Cardiovascular Sciences of Education Ministry, Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China
    PLoS ONE 6:e23554. 2011
    ..Therefore, by promoting the differentiation and migration of BMCs, PGE2 reinforced their neovascularization by binding to the receptor of EP4 in an AMPK-dependent manner. PGE2 may have clinical value in ischemic heart disease...
  60. doi Transforming growth factor-β-activated kinase 1 regulates angiogenesis via AMP-activated protein kinase-α1 and redox balance in endothelial cells
    Nina Zippel
    From the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt, Germany and DZHK German Centre for Cardiovascular Research partner site Rhine Main N Z, R A M, T F, R P, E B, I F, B F and Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany B S, N W
    Arterioscler Thromb Vasc Biol 33:2792-9. 2013
    ..Although TAK1(-/-) mice display defects in developmental vasculogenesis, the role of TAK1 in endothelial cells has not been investigated in detail...
  61. doi Role of PrP(C) Expression in Tau Protein Levels and Phosphorylation in Alzheimer's Disease Evolution
    C Vergara
    Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia, Baldiri Reixac 15 21, 08028, Barcelona, Spain
    Mol Neurobiol 51:1206-20. 2015
    ..Taken together, these results suggest a protective role for PrP(C) in AD by downregulating tau expression, and they point to this protein as being crucial in the molecular events that lead to neurodegeneration in AD. ..
  62. doi AMPK activation inhibits expression of proinflammatory mediators through downregulation of PI3K/p38 MAPK and NF-κB signaling in murine macrophages
    Bee Piao Huang
    1 Department of Pathology, Tungs Taichung Metroharbor Hospital, Taichung, Taiwan
    DNA Cell Biol 34:133-41. 2015
    ....
  63. doi Activation of p38 in C2C12 myotubes following ATP depletion depends on extracellular glucose
    Chia George Hsu
    School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA, 30332, USA
    J Physiol Biochem 71:253-65. 2015
    ..Although p38 is strongly phosphorylated during ATP depletion, this appears to be an indirect consequence of accelerated glycolysis. ..
  64. pmc AMPKα1 knockout enhances nociceptive behaviors and spinal glutamatergic synaptic activities via production of reactive oxygen species in the spinal dorsal horn
    Dylan W Maixner
    Department of Pharmaceutical and Biomedical Sciences, The University of Georgia College of Pharmacy, Athens, GA 30602, USA
    Neuroscience 326:158-69. 2016
    ..Thus, targeting AMPKα1 may represent an effective approach for the treatment of pathological pain conditions associated with neuroinflammation at the spinal dorsal horn. ..
  65. pmc AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy
    Zhonglin Xie
    Section of Molecular Medicine, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Autophagy 7:1254-5. 2011
    ..We conclude that AMPK activation protects cardiac structure and function by increasing cardiac autophagy in the diabetic heart...
  66. ncbi Antagonistic control of muscle cell size by AMPK and mTORC1
    Remi Mounier
    Inserm U1016, Centre National de la Recherche Scientifique CNRS, UMR8104, University Paris Descartes, Institut Cochin, Paris, France
    Cell Cycle 10:2640-6. 2011
    ..Thus, the crosstalk between AMPK and mTORC1 signaling is a highly regulated way to control changes in muscle growth and metabolic rate imposed by external cues...
  67. pmc Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway
    I Chen Peng
    Division of Biomedical Sciences, University of California, Riverside, 92521, USA
    Am J Physiol Endocrinol Metab 302:E1560-8. 2012
    ..These results indicate that CaMKKβ/AMPK signaling is an important molecular component in regulating lipid metabolism in adipocytes responding to glucagon and could be a therapeutic target for the dysregulation of energy storage...
  68. pmc Molecular mechanisms of estrogen receptors' suppression of lipogenesis in pancreatic β-cells
    Joseph P Tiano
    Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Endocrinology 153:2997-3005. 2012
    ..This study identifies extranuclear ER pathways involving STAT3 and AMP-activated protein kinase in the genetic control of lipogenesis with therapeutic implications to protect β-cells in type 2 diabetes...
  69. pmc Cells lacking the fumarase tumor suppressor are protected from apoptosis through a hypoxia-inducible factor-independent, AMPK-dependent mechanism
    Chiara Bardella
    Department of Oncological Sciences, University of Torino, School of Medicine, Turin, Italy
    Mol Cell Biol 32:3081-94. 2012
    ..These findings reveal a new mechanism of tumorigenesis due to FH loss and an unexpected pro-oncogenic role for AMPK that is important in considering AMPK reactivation as a therapeutic strategy against cancer...
  70. pmc AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress
    Anthony J Cura
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, USA
    Am J Physiol Cell Physiol 303:C806-14. 2012
    ....
  71. pmc AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization
    Hildegard I D Mack
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Autophagy 8:1197-214. 2012
    ..Taken together these data identify an ULK1-AMPK signaling cassette involved in regulation of the autophagy machinery...
  72. pmc AMP-activated protein kinase restricts IFN-γ signaling
    Gordon P Meares
    Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 190:372-80. 2013
    ..Overall, these findings provide the first link between AMPK and STAT1 and may provide important clues about how bioenergetics and inflammation are linked...
  73. pmc AMP activated protein kinase is indispensable for myocardial adaptation to caloric restriction in mice
    Kai Chen
    Cardiovascular Health Research Center, Sanford Research, University of South Dakota, Sioux Falls, South Dakota, United States of America
    PLoS ONE 8:e59682. 2013
    ....
  74. pmc Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination
    Jee Hyun Um
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 110:9873-8. 2013
    ..Our results suggest that V(D)J recombination can be regulated by AMPK activation, providing a potential new link between metabolic stress and development of B and T lymphocytes...
  75. pmc Activation of AMP kinase alpha1 subunit induces aortic vasorelaxation in mice
    Françoise Goirand
    Universite Paris Sud, IFR 141, Chatenay Malabry, France
    J Physiol 581:1163-71. 2007
    ..Rings of thoracic aorta were isolated from C57Bl6 mice and mice deficient in the AMPK catalytic alpha1 (AMPKalpha1-/-) or alpha2 (AMPKalpha2-/-) subunit and their littermate controls, and mounted in an organ bath...
  76. pmc Quantitative traits for the tail suspension test: automation, optimization, and BXD RI mapping
    Heena V Lad
    Social, Genetic and Developmental Psychiatry Centre PO82, Institute of Psychiatry, King s College London, London, SE5 8AF, United Kingdom
    Mamm Genome 18:482-91. 2007
    ..A second trial of the test has greater duration of immobility and a completely different genetic profile. Frequency of mobility is also an independent phenotype, with a distal chromosome 1 locus...
  77. doi Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains
    Abdallah K Al-Hakim
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 411:249-60. 2008
    ..The results of the present study demonstrate that NUAK1 and MARK4 are substrates of USP9X and provide the first evidence that AMPK family kinases are regulated by unusual Lys(29)/Lys(33)-linked polyubiquitin chains...
  78. doi Role of AMP-activated protein kinase in autophagy and proteasome function
    Rosa Viana
    Instituto de Biomedicina de Valencia, CSIC, Nutrient signaling, Jaime Roig 11, 46010 Valencia, Spain Centre for Biomedical Research on Rare Diseases CIBERER, Valencia, Spain
    Biochem Biophys Res Commun 369:964-8. 2008
    ..On the other hand, AICAR inhibits the proteasomal degradation of proteins by an AMPK-dependent mechanism. This is a novel function of AMPK that allows the regulation of proteasomal activity under conditions of energy demand...
  79. doi Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice
    Jian Yang
    Department of Physiology, The University of South Alabama College of Medicine, MSB 3074, 307 University Boulevard, Mobile, AL 36688 0002, USA
    Biochem Biophys Res Commun 370:248-53. 2008
    ....
  80. pmc Stretch-induced activation of AMP kinase in the lung requires dystroglycan
    G R Scott Budinger
    Division of Pulmonary and Critical Care Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Am J Respir Cell Mol Biol 39:666-72. 2008
    ..These results suggest that exposure to cyclic stretch activates the metabolic sensing pathway AMPK in the lung epithelium and supports a novel role for dystroglycan in this mechanotransduction...
  81. pmc Autophagy: a new phase in the maturation of growth plate chondrocytes is regulated by HIF, mTOR and AMP kinase
    Vickram Srinivas
    Department of Orthopaedic Surgery, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Cells Tissues Organs 189:88-92. 2009
    ..Once autophagy is activated, the postmitotic chondrocytes would be expected to remain viable in their unique microenvironment and complete their life cycle...
  82. doi Regulation of Cl(-) secretion by AMPK in vivo
    Patthara Kongsuphol
    Department of Physiology, University of Regensburg, Germany
    Pflugers Arch 457:1071-8. 2009
    ..Using AMPKalpha1(-/-) mice and wild-type littermates, we demonstrate that phenformin, an activator of AMPK, strongly inhibits ..
  83. doi Regulation of erythrocyte survival by AMP-activated protein kinase
    Michael Foller
    Department of Physiology, University of Tubingen, Tubingen, Germany
    FASEB J 23:1072-80. 2009
    ..As compared with erythrocytes from wild-type littermates (ampk(+/+)), erythrocytes from AMPKalpha1-deficient mice (ampk(-/-)) were significantly more susceptible to the eryptotic effect of energy depletion...
  84. doi Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity
    Woo Sik Kim
    Institute of Molecular Biology and Genetics, Department of Biological Sciences, Seoul National University, San 56 1, Sillim dong, Kwanak gu, Seoul 151 742, Korea
    Am J Physiol Endocrinol Metab 296:E812-9. 2009
    ..Together, these data suggest that BBR would improve fatty liver in obese subjects, which is probably mediated not only by peripheral AMPK activation but also by neural signaling from the central nervous system...
  85. pmc Effects of WY-14,643 on the phosphorylation and activation of AMP-dependent protein kinase
    Suthat Liangpunsakul
    Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine and Roudebush Veterans Administration Medical Center, 545 N Barnhill Drive, Indianapolis, IN 46202, USA
    Arch Biochem Biophys 485:10-5. 2009
    ..Whether WY-14,643, a PPARalpha agonist, has any effects on AMPK is not known. The aim of this study was to investigate the effect of WY-14,643 on AMPK activity...
  86. doi Important role for AMPKalpha1 in limiting skeletal muscle cell hypertrophy
    Remi Mounier
    INSERM U567, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, 75014 Paris, France
    FASEB J 23:2264-73. 2009
    ..The purpose of this investigation was to determine the role of the AMPKalpha1 catalytic subunit on muscle cell size control and adaptation to muscle hypertrophy...
  87. pmc Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF
    Rosaura Esteve-Puig
    Animal Models and Cancer Laboratory, Medical Oncology Research Program, Vall d Hebron Research Institute VHIO, Vall d Hebron Hospital, Barcelona, Spain
    PLoS ONE 4:e4771. 2009
    ..Additionally, LKB1(Ser428) becomes phosphorylated in a RAS-Erk1/2-p90(RSK) pathway dependent manner. However, the connection between the RAS pathway and LKB1 is mostly unknown...
  88. pmc Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity
    Narender Nath
    Department of Pediatrics, Medical University of South Carolina, SC 29425, USA
    Biochem Biophys Res Commun 386:16-20. 2009
    ..b>AMPKalpha1 is predominantly expressed in T cells and antigen presenting cells (APCs), which are primarily involved in EAE ..
  89. doi Non-CDK-bound p27 (p27(NCDK)) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways
    Mia A Björklund
    Molecular Cancer Biology Program, Biomedicum Helsinki and Haartman Institute, University of Helsinki, Helsinki, Finland
    Exp Cell Res 316:762-74. 2010
    ..These results indicate that p27(NCDK) is a sensitive marker for both cell stress and proliferation over and above p27 and is regulated by Akt/PKB and AMPK pathways...
  90. pmc Metabolic regulation of neuronal plasticity by the energy sensor AMPK
    Wyatt B Potter
    Department of Neurology, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 5:e8996. 2010
    ..Our work opens up the possibility of using modulators of energy metabolism to control neuronal plasticity in diseases and conditions of aberrant plasticity such as epilepsy...
  91. pmc AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552
    Junxing Zhao
    Developmental Biology Group, Department of Animal Science, College of Agriculture, University of Wyoming, Laramie, WY 82071, USA
    Biochem Biophys Res Commun 395:146-51. 2010
    ....
  92. pmc AMPKalpha1 deletion shortens erythrocyte life span in mice: role of oxidative stress
    Shaobin Wang
    Division of Endocrinology and Diabetes, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 285:19976-85. 2010
    ..Here, we report that AMPKalpha1 is the predominant isoform of AMPK in murine erythrocytes and mice globally deficient in AMPKalpha1 (AMPKalpha1(-..
  93. pmc The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
    Na Zhang
    Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Metab 11:364-78. 2010
    ..These results demonstrate that FIH acts to a significant degree through the nervous system to regulate metabolism...
  94. pmc Benzo(a)pyrene causes PRKAA1/2-dependent ID2 loss in trophoblast stem cells
    Yufen Xie
    CS Mott Center for Human Growth and Development, Wayne State University School of Medicine, Detroit, Michigan
    Mol Reprod Dev 77:533-9. 2010
    ..stress-activated protein kinase/jun kinase (MAPK8/9) in embryos, AMP-activated protein kinase alpha1/2 subunits (PRKAA1/2) in somatic cells, and inhibits the proliferation of trophoblast cell lineages...
  95. doi SPARC interacts with AMPK and regulates GLUT4 expression
    Haiyan Song
    Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, XueFu Road 246, Harbin 150080, China
    Biochem Biophys Res Commun 396:961-6. 2010
    ..These results provide a starting point for efforts to clarify the relationship between AMPK and SPARC, and deepen our understanding of their roles in fat and glucose metabolism...
  96. pmc Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia
    Craig Beall
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Biochem J 429:323-33. 2010
    ..These results show that AMPK alpha2 activity is necessary to maintain normal pancreatic beta-cell glucose sensing, possibly by maintaining high beta-cell levels of UCP2...
  97. pmc AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction
    Subat Turdi
    Division of Pharmaceutical Sciences, University of Wyoming, Laramie, WY 82071, USA
    Aging Cell 9:592-606. 2010
    ..Collectively, our data suggest a role for AMPK deficiency in aging-induced cardiac dysfunction possibly through disrupted mitochondrial function and ROS production...
  98. doi AMP-activated protein kinase positively regulates FGF-2-stimulated VEGF synthesis in osteoblasts
    Kenji Kato
    Department of Orthopedic Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    Biochem Biophys Res Commun 400:123-7. 2010
    ..These results strongly suggest that AMPK positively regulates the FGF-2-stimulated VEGF synthesis via p44/p42 MAP kinase and SAPK/JNK in osteoblasts...
  99. pmc Ser149 is another potential PKA phosphorylation target of Cdc25B in G2/M transition of fertilized mouse eggs
    Jianying Xiao
    Institute of Pathology and Pathopysiology, China Medical University, Shenyang, Liaoning Province 110001, China
    J Biol Chem 286:10356-66. 2011
    ....
  100. doi Functional modulation of AMP-activated protein kinase by cereblon
    Kwang Min Lee
    School of Life Sciences and Cell Dynamics Research Center, Gwangju Institute Science and Technology GIST, Gwangju 500 712, Republic of Korea
    Biochim Biophys Acta 1813:448-55. 2011
    ..Moreover, AMPK α1 can be potently activated by suppressing endogenous CRBN using CRBN-specific small hairpin RNAs. Thus, CRBN may act as a negative modulator of the AMPK signaling pathway in vivo...
  101. pmc Isoform-selective 5'-AMP-activated protein kinase-dependent preconditioning mechanisms to prevent postischemic leukocyte-endothelial cell adhesive interactions
    F Spencer Gaskin
    Departments of Medical Pharmacology and Physiology, University of Missouri, Columbia, 65212, USA
    Am J Physiol Heart Circ Physiol 300:H1352-60. 2011
    ..In sharp contrast, EPC appears to be triggered by an AMPK α(2)-isoform-dependent mechanism...

Research Grants5

  1. Mitochondrial Regulation of Hyperoxic Cell Death
    GR BUDINGER; Fiscal Year: 2005
    ..If oxygen therapy exacerbates lung injury, strategies to minimize hyperoxic exposure might improve outcomes in patients with acute lung injury. ..
  2. FORMAL METHODS APPLIED TO BIOLOGICAL SIGNALING NETWORKS
    Keith Laderoute; Fiscal Year: 2006
    ..abstract_text> ..
  3. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
    ..Furthermore, these studies will benefit the development of in vitro systems where either meiotic arrest or completion of meiotic maturation is the desired endpoint. ..
  4. HYPOXIC STRESS MECHANISMS IN RADIATION AND CHEMOTHERAPY
    Keith Laderoute; Fiscal Year: 2009
    ..An understanding of these MTF-1-dependent properties should aid in the development of novel prognostic and new modalities for neoplastic diseases. ..
  5. ROLE OF AMPK IN TUMOR DEVELOPMENT AND THERAPY
    Keith R Laderoute; Fiscal Year: 2010
    ..Ultimately, we intend to determine whether the AMPK "emergency stress response" can be exploited for the therapy or prognosis of human cancer. ..