Prdx1

Summary

Gene Symbol: Prdx1
Description: peroxiredoxin 1
Alias: MSP23, NkefA, OSF-3, OSF3, PAG, Paga, PrdxI, PrxI, TDX2, TPxA, Tdpx2, prx1, peroxiredoxin-1, Trx dependent peroxide reductase 2, macrophage 23 Kd stress protein, macrophage 23 kDa stress protein, macrophage 23kDa stress protein, macrophase stress protein 22kDa, macrophase stress protein 23 kd, osteoblast-specific factor 3, proliferation-associated gene A, thioredoxin peroxidase 2, thioredoxin-dependent peroxide reductase 2
Species: mouse

Top Publications

  1. ncbi Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation
    Hyun Ae Woo
    Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    Science 300:653-6. 2003
  2. ncbi Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression
    Carola A Neumann
    Center for Blood Research and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:561-5. 2003
  3. doi Induction of peroxiredoxin I gene expression by LPS involves the Src/PI3K/JNK signalling pathway
    Antje Bast
    Department of Medical Biochemistry and Molecular Biology, Ernst Moritz Arndt University of Greifswald, 17487 Greifswald, Germany
    Biochim Biophys Acta 1799:402-10. 2010
  4. pmc Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4
    Jonah R Riddell
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 184:1022-30. 2010
  5. ncbi Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1
    Rachel A Egler
    Department of Pediatrics, Section of Hematology Oncology, Children s Hospital of Pittsburgh, Rangos Research Center, 3460 Fifth Ave, USA
    Oncogene 24:8038-50. 2005
  6. doi Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development
    Marc Pirson
    Group of Animal Molecular and Cellular Biology, Institut des Sciences de la Vie ISV, Universite Catholique de Louvain, 1348, Louvain la Neuve, Belgium
    J Comp Neurol 523:2599-617. 2015
  7. ncbi Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death
    S W Shan
    Department of Anatomy, Basic Medical Science Building, Chinese University of Hong Kong, Shatin, Hong Kong
    Dev Dyn 233:266-81. 2005
  8. pmc Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation
    Xianghuai Lu
    Division of Endocrinology, Department of Medicine, VA Medical Center, Emory University School of Medicine, Atlanta, GA, USA
    J Bone Miner Res 26:209-19. 2011
  9. pmc Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo
    Rong Rong Tao
    1 Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, China
    Antioxid Redox Signal 21:1-16. 2014
  10. doi Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells
    Sun Uk Kim
    Aging Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, Republic of Korea Department of Functional Genomics, University of Science and Technology UST, Daejeon, Republic of Korea National Primate Research Center, KRIBB, Chungcheongbuk Do, Republic of Korea Division of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    Stem Cells 32:998-1011. 2014

Research Grants

Scientific Experts

  • Lianqin Li
  • N S Wolf
  • Hyun Ae Woo
  • Li zhu Lin
  • Sun Uk Kim
  • Jonah R Riddell
  • Tetsuro Ishii
  • Jin Man Kim
  • Dae Yeul Yu
  • Tae Hoon Lee
  • Ying Hao Han
  • Toru Yanagawa
  • Eiji Warabi
  • Marc Pirson
  • Nastiti Wijayanti
  • Rong Rong Tao
  • Young Ho Park
  • Hu Nan Sun
  • Sang Ho Lee
  • Sang Won Kang
  • Dong Seok Lee
  • Kyu Tae Chang
  • Edward V Prochownik
  • Rotem Engelman
  • Carola A Neumann
  • Rie Yanagisawa
  • Aaron J Huebner
  • A Morinaka
  • Norihiro Kikuchi
  • Xianghuai Lu
  • Sandra O Gollnick
  • Antje Bast
  • Edward E Schmidt
  • Sue Goo Rhee
  • J Anthony Graves
  • Ye Yan
  • Juxiang Cao
  • Janka Kisucka
  • Michelle T Barati
  • Kristi Rothermund
  • Alexandre Diet
  • Ruying Chang
  • Florian L Muller
  • Alla A Bondareva
  • Junya Uwayama
  • James P Conway
  • Thomas Kietzmann
  • Stephan Immenschuh
  • Richard A Van Etten
  • Rachel A Egler
  • S W Shan
  • Isamu Hoshino
  • Tong Shin Chang
  • Bo Zhang
  • Yi Yang
  • Kwang Ning Chang
  • Alexander Hess
  • Bernard Knoops
  • A Bast
  • Baojie Li
  • Ling Juan Hong
  • Feng Han
  • Ying Mei Lu
  • Wei Feng Ye
  • Song Mei Huang
  • Huan Wang
  • Su Hong
  • Christopher Stuart Wilcox
  • Ji Yun Huang
  • Ikuo Shoji
  • Kohji Fukunaga
  • Jung Il Chae
  • En Yin Lai
  • Sang Hee Lee
  • Zhao Mei Mu
  • Sung Sik Choi
  • In Sung Song
  • Seung Cheol Choi
  • Dan Yan Zhu
  • Qian Huang
  • Nan Nan Lu
  • Yi Jia Lou
  • Mei Hua Liao
  • Jin Mei Hua
  • Tamar Ziv
  • Elias S J Arner
  • Jianqiang Xu
  • Sang Rae Lee
  • Pnina Weisman-Shomer
  • Moran Benhar

Detail Information

Publications48

  1. ncbi Reversing the inactivation of peroxiredoxins caused by cysteine sulfinic acid formation
    Hyun Ae Woo
    Center for Cell Signaling Research and Division of Molecular Life Sciences, Ewha Womans University, Seoul 120 750, Korea
    Science 300:653-6. 2003
    ..The mammalian cells' ability to reduce protein sulfinic acid might serve as a mechanism to repair oxidatively damaged proteins or represent a new type of cyclic modification by which the function of various proteins is regulated...
  2. ncbi Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression
    Carola A Neumann
    Center for Blood Research and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 424:561-5. 2003
    ..We have generated mice with targeted inactivation of Prdx1, a member of the peroxiredoxin family of antioxidant enzymes...
  3. doi Induction of peroxiredoxin I gene expression by LPS involves the Src/PI3K/JNK signalling pathway
    Antje Bast
    Department of Medical Biochemistry and Molecular Biology, Ernst Moritz Arndt University of Greifswald, 17487 Greifswald, Germany
    Biochim Biophys Acta 1799:402-10. 2010
    ..Our results suggest that the up-regulation of Prx I gene expression by LPS is part of the cellular response to stress and may protect against oxidative stress-related injury in RAW 264.7 cells...
  4. pmc Peroxiredoxin 1 stimulates secretion of proinflammatory cytokines by binding to TLR4
    Jonah R Riddell
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 184:1022-30. 2010
    b>Peroxiredoxin 1 (Prx1) is an antioxidant and molecular chaperone that can be secreted from tumor cells. Prx1 is overexpressed in many cancers, and elevation of Prx1 is associated with poor clinical outcome...
  5. ncbi Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1
    Rachel A Egler
    Department of Pediatrics, Section of Hematology Oncology, Children s Hospital of Pittsburgh, Rangos Research Center, 3460 Fifth Ave, USA
    Oncogene 24:8038-50. 2005
    ..We previously demonstrated that peroxiredoxin 1 (Prdx1), a scavenger of reactive oxygen species (ROS), interacts with a region of the c-Myc transcriptional ..
  6. doi Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development
    Marc Pirson
    Group of Animal Molecular and Cellular Biology, Institut des Sciences de la Vie ISV, Universite Catholique de Louvain, 1348, Louvain la Neuve, Belgium
    J Comp Neurol 523:2599-617. 2015
    ..Our results highlight several patterns that contrast with available data for the adult. Indeed, Prdx1, Prdx4, and Prdx6, which are expressed in glial cells in the adult CNS, present clear neuronal localization in ..
  7. ncbi Comparative proteomic analysis identifies protein disulfide isomerase and peroxiredoxin 1 as new players involved in embryonic interdigital cell death
    S W Shan
    Department of Anatomy, Basic Medical Science Building, Chinese University of Hong Kong, Shatin, Hong Kong
    Dev Dyn 233:266-81. 2005
    ..5. We established that protein disulfide isomerase (PDI) expression was up-regulated at E13.5, while peroxiredoxin 1 (Prdx1) expression was down-regulated at this time point...
  8. pmc Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation
    Xianghuai Lu
    Division of Endocrinology, Department of Medicine, VA Medical Center, Emory University School of Medicine, Atlanta, GA, USA
    J Bone Miner Res 26:209-19. 2011
    ..One protein, the paired related homeobox protein (Prx1), had been shown previously to have a critical role in limb bud formation and skeletal patterning...
  9. pmc Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo
    Rong Rong Tao
    1 Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, China
    Antioxid Redox Signal 21:1-16. 2014
    ..b>Peroxiredoxin 1 (Prx1) can initiate the antioxidant response by scavenging free radicals...
  10. doi Dominant role of peroxiredoxin/JNK axis in stemness regulation during neurogenesis from embryonic stem cells
    Sun Uk Kim
    Aging Research Center, Korea Research Institute of Bioscience and Biotechnology KRIBB, Daejeon, Republic of Korea Department of Functional Genomics, University of Science and Technology UST, Daejeon, Republic of Korea National Primate Research Center, KRIBB, Chungcheongbuk Do, Republic of Korea Division of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    Stem Cells 32:998-1011. 2014
    ....
  11. doi Oligomeric peroxiredoxin-I is an essential intermediate for p53 to activate MST1 kinase and apoptosis
    A Morinaka
    Laboratory of Intracellular Signaling, Institute for Protein Research, Osaka University, Osaka, Japan
    Oncogene 30:4208-18. 2011
    ..Collectively, our results show a novel PRX-I function to cause cell death in response to high levels of oxidative stress by activating MST1, which underlies the p53-dependent cytotoxicity caused by anticancer agents...
  12. ncbi [Effects of yiqi chutan recipe on tumor growth, survival time and expressions of PRDX-1 and PRDX-6 in Lewis lung carcinoma model mice with pi-deficiency syndrome]
    Li zhu Lin
    Department of Oncology, First Teaching Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou
    Zhongguo Zhong Xi Yi Jie He Za Zhi 31:99-103. 2011
    ....
  13. pmc Peroxiredoxin 1 stimulates endothelial cell expression of VEGF via TLR4 dependent activation of HIF-1α
    Jonah R Riddell
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 7:e50394. 2012
    ..b>Peroxiredoxin 1 (Prx1) was recently identified as an endogenous ligand for TLR4 that is secreted from CaP cells and promotes ..
  14. ncbi Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress
    Ying Hao Han
    Aging Research Center, KRIBB, Daejeon, Korea
    BMB Rep 45:560-4. 2012
    ....
  15. doi Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure
    Rie Yanagisawa
    Center for Environmental Health Sciences, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    J Biochem 152:595-601. 2012
    ..However, its precise mechanisms are not fully elucidated. Here, we examined the role of peroxiredoxin I (PrxI) in O(3)-induced pulmonary inflammation using PrxI null (PrxI(-/-)) and wild-type (WT) mice...
  16. pmc Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero
    Aaron J Huebner
    Department of Dermatology and Charles C Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Denver, CO 80045, USA
    Dev Cell 23:1238-46. 2012
    ..Our findings reveal that the functions of Nrf2 and the composition of amniotic fluid have coevolved to ensure the formation of a functional barrier...
  17. pmc Multilevel regulation of 2-Cys peroxiredoxin reaction cycle by S-nitrosylation
    Rotem Engelman
    Department of Biochemistry, Rappaport Institute for Research in the Medical Sciences, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Biol Chem 288:11312-24. 2013
    ..In this study we investigated how NO/SNO may affect the redox cycle of mammalian peroxiredoxin-1 (Prx1), a representative of the 2-Cys Prxs, a group of thioredoxin (Trx)-dependent peroxidases...
  18. doi Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activation
    Sun Uk Kim
    National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk 363 883, Republic of Korea
    J Neuroimmunol 259:26-36. 2013
    ..The findings of our work suggest possible strategies for developing novel therapies to treat inflammation-associated degenerative neurological diseases by targeting the induction of Prx I in microglial cells...
  19. ncbi Cloning and characterization of OSF-3, a new member of the MER5 family, expressed in mouse osteoblastic cells
    S Kawai
    Pharma Research Laboratories, Hoechst Japan Limited, Saitama
    J Biochem 115:641-3. 1994
    ..A cDNA clone was identified and sequenced, encoding a protein designated as osteoblast specific factor 3 (OSF-3) comprising 199 amino acids...
  20. doi Crucial role of peroxiredoxin III in placental antioxidant defense of mice
    Lianqin Li
    Department of Cell Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    FEBS Lett 582:2431-4. 2008
    ..Nevertheless, we noticed enhanced expression of PrxI in erythrocytes of pregnant knockout mice...
  21. ncbi Inhibition of phorbol ester-dependent peroxiredoxin I gene activation by lipopolysaccharide via phosphorylation of RelA/p65 at serine 276 in monocytes
    Nastiti Wijayanti
    Institut für Klinische Immunologie und Transfusionsmedizin, Justus Liebig Universitat Giessen, D 35392 Giessen, Germany
    Free Radic Biol Med 44:699-710. 2008
    ..In summary, LPS-dependent inhibition of Prx I gene activation by TPA in monocytes is regulated via a pathway that involves phosphorylation of the NF-kappaB subunit p65 at serine 276...
  22. pmc Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis
    Janka Kisucka
    Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Circ Res 103:598-605. 2008
    ..b>Prdx1 is known to be important to protect red blood cells against reactive oxygen species and in tumor prevention...
  23. pmc Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc
    J Anthony Graves
    Department of Pediatrics, Division of Hematology Oncology, Children s Hospital of Pittsburgh, and University of Pittsburgh Medical Center, Department of Microbiology and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Biol Chem 284:6520-9. 2009
    ..Loss of the most ubiquitous member of the family, Prx1, is associated with the accumulation of oxidatively damaged DNA and a tumor-prone phenotype...
  24. pmc Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity
    Juxiang Cao
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics Medical Medical University of South Carolina, Charleston, SC 29425, USA
    EMBO J 28:1505-17. 2009
    ..However, the exact mechanisms are still unclear. As mice lacking the peroxidase peroxiredoxin1 (Prdx1) produce more cellular ROS and die prematurely of cancer, they offer an ideal model system to study ROS-induced ..
  25. pmc The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2
    Ye Yan
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 138:1209-21. 2009
    ..Here we show that the antioxidant scavenger peroxiredoxin1 (Prdx1) interacts with GDE2, and that loss of Prdx1 causes motor neuron deficits analogous to GDE2 ablation...
  26. doi Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling
    Hyun Ae Woo
    Ewha Womans University, Seoul, Korea
    Cell 140:517-28. 2010
    ..We now show that PrxI associated with membranes is transiently phosphorylated on tyrosine-194 and thereby inactivated both in cells ..
  27. doi Aggravation of bleomycin-induced pulmonary inflammation and fibrosis in mice lacking peroxiredoxin I
    Norihiro Kikuchi
    Department of Respiratory Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Am J Respir Cell Mol Biol 45:600-9. 2011
    ....
  28. ncbi Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway
    Alexander Hess
    Institut fur Klinische Chemie und Pathobiochemie, Justus Liebig Universitat Giessen, Giessen D 35392, Germany
    J Biol Chem 278:45419-34. 2003
    ..The data indicate that a protein kinase C, Ras, MEKK1, p38 MAPK signaling pathway plays a major role for the transcriptional up-regulation of Prx I gene expression...
  29. ncbi Cloning and sequence analysis of candidate human natural killer-enhancing factor genes
    H Shau
    Division of Surgical Oncology, UCLA School of Medicine 90024 1782
    Immunogenetics 40:129-34. 1994
    ..Therefore, as well as for immunoregulation of NK activity, NKEF may be important for cells in coping with oxidative insults...
  30. ncbi Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein
    T Ishii
    Department of Biochemistry, University of Tsukuba, Ibaraki, Japan
    J Biol Chem 268:18633-6. 1993
    ..A cDNA encoding a novel stress-inducible protein, designated MSP23 (macrophage 23-kDa stress protein), was cloned from a cDNA library of the macrophages by differential screening...
  31. ncbi Characterization of mouse peroxiredoxin I genomic DNA and its expression
    T H Lee
    Korea Research Institute of Bioscience and Biotechnology, P O Box 115, Yusong, Taejon, South Korea
    Gene 239:243-50. 1999
    ..e. the Prx I gene was well conserved in human and mice via its anti-oxidant activity...
  32. ncbi Polypeptides differentially expressed in imaginal discs define the peroxiredoxin family of genes in Drosophila
    J Rodriguez
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Eur J Biochem 267:487-97. 2000
    ..The microsequence data showed identity with amino acids encoded by the human proliferation association gene, pag, which is a thiol-specific antioxidant...
  33. ncbi Pathways of induction of peroxiredoxin I expression in osteoblasts: roles of p38 mitogen-activated protein kinase and protein kinase C
    Baojie Li
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 277:12418-22. 2002
    ....
  34. ncbi Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells
    A Bast
    Department of Medical Biochemistry and Molecular Biology, Ernst Moritz Arndt University Greifswald, Germany
    Diabetologia 45:867-76. 2002
    ..We investigated whether peroxiredoxins I and II are present in pancreatic beta cells and if they are inducible by oxidative and nitrosative stress...
  35. ncbi Pag, a putative tumor suppressor, interacts with the Myc Box II domain of c-Myc and selectively alters its biological function and target gene expression
    Zhao Mei Mu
    Section of Hematology Oncology, The Children s Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 277:43175-84. 2002
    ..A yeast two-hybrid screen identified Pag as a MBII-interacting protein...
  36. pmc Identification of galectin I and thioredoxin peroxidase II as two arsenic-binding proteins in Chinese hamster ovary cells
    Kwang Ning Chang
    Department of Life Science, National Central University, Chung Li, Taoyuan, Taiwan 32054, Republic of China
    Biochem J 371:495-503. 2003
    ..It is suggested that Gal-1 and TPX-II are two proteins that serve as high-affinity binding sites for As(III) and thus both may be involved in the biological action of As(III)...
  37. ncbi Site-specific gene targeting in mouse embryonic stem cells with intact bacterial artificial chromosomes
    Yi Yang
    Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Nat Biotechnol 21:447-51. 2003
    ..Correctly integrated clones were identified by a simple screening procedure based on chromosomal fluorescence in situ hybridization (FISH). To date, five mutant lines have been generated and bred to homozygosity by this approach...
  38. ncbi Regulation of peroxiredoxins by nitric oxide in immunostimulated macrophages
    Alexandre Diet
    Institut de Chimie des Substances Naturelles CNRS, 91190 Gif sur Yvette, France
    J Biol Chem 282:36199-205. 2007
    ....
  39. ncbi Quantitative trait locus mapping for age-related cataract severity and synechia prevalence using four-way cross mice
    Norman Wolf
    Department of Pathology, University of Washington, Seattle 98195 7470, USA
    Invest Ophthalmol Vis Sci 45:1922-9. 2004
    ..The goal of this study was to map mouse quantitative trait loci (QTL) that influence the development of murine age-related cataract and synechia, by using a genetically heterogeneous mouse population bred by a four-way cross...
  40. pmc Cloning and expression of mouse peroxiredoxin I in IEC-6 Cells
    Bo Zhang
    Institute of Combined Injury of PLA, State Key Laboratory of Trauma, Third Military Medical University, Gaotanyan Street 30, Chongqing 400038, China
    World J Gastroenterol 10:2109-12. 2004
    ..To clone and express mouse peroxiredoxin I in IEC-6 cells...
  41. ncbi Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine
    Tong Shin Chang
    Laboratory of Cell Signaling, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:50994-1001. 2004
    ..Finally, depletion of human Srx by RNA interference suggested that Srx is largely responsible for reduction of the Cys-SO2H of Prx in A549 human cells...
  42. ncbi Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal cancer cells
    Isamu Hoshino
    Department of Frontier Surgery M9, Graduate School of Medicine, Chiba University, Japan
    Clin Cancer Res 11:7945-52. 2005
    ..The purpose of this study is to reveal the effect of FK228 on gene expression in the cell and to determine the mechanism of the antitumor activity of FK228 for further clinical applications...
  43. ncbi Tissue Prx I in the protection against Fe-NTA and the reduction of nitroxyl radicals
    Junya Uwayama
    Biomolecular and Integrated Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 339:226-31. 2006
    ..These results demonstrate that Prx I-/- mice have less reducing activity and are more susceptible to the damage mediated by reactive oxygen species in vivo than wild-type mice...
  44. ncbi Dual role of peroxiredoxin I in macrophage-derived foam cells
    James P Conway
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 281:27991-8001. 2006
    ..These results are consistent with multiple roles for Prx I in macrophage-derived foam cells that include functionality as both an antioxidant and a regulator of oxidant-sensitive signal transduction...
  45. ncbi Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress
    Ruying Chang
    Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Cell Biochem 100:267-78. 2007
    ..Thus, our results suggest that eEF1A-2 interacts with Prdx-I to functionally provide cells with extraordinary resistance to oxidative stress-induced cell death...
  46. ncbi Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice
    Michelle T Barati
    Department of Medicine, University of Louisville, Louisville, Kentucky 40202, USA
    Am J Physiol Renal Physiol 293:F1157-65. 2007
    ..Of 105 analyzed spots, expression of 40 proteins, including the antioxidative enzymes peroxiredoxin 1 and 3, glutathione peroxidase 1, and SOD-1, was increased with diabetes, suggesting an adaptive response to ..
  47. ncbi Trends in oxidative aging theories
    Florian L Muller
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Free Radic Biol Med 43:477-503. 2007
    ..Studies in mice argue for a role of oxidative stress in age-related disease, especially cancer; however, with regard to aging per se, the data either do not support or remain inconclusive on whether oxidative stress determines life span...
  48. pmc Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome
    Alla A Bondareva
    VMB, Molecular Biosciences, 960 Technology Blvd, Montana State University, Bozeman, MT 59718, USA
    Free Radic Biol Med 43:911-23. 2007
    ..Conserved responses to Txnrd1 disruption likely allowed proliferation and limited differentiation of the mutant embryo cells...

Research Grants2

  1. Molecular Mechanisms of Aging: 33rd Ann. Mtg. of AGE
    Norman Wolf; Fiscal Year: 2004
    ..Dr. Bickford has investigated hotel accommodations there and has found that both the Radisson and the Hilton offer excellent accommodations for the meeting. She is negotiating with both. ..
  2. DIETARY & GENETIC CONTROL OF ROS DAMAGE TO THE LENS
    Norman S Wolf; Fiscal Year: 2010
    ..These will aid in the search for initiating events and the mechanisms leading up to the cataract formation. ..