Genomes and Genes
Gene Symbol: Ppp1r9b
Description: protein phosphatase 1, regulatory subunit 9B
Alias: SPL, Spn, neurabin-2, neurabin-II, spinophilin
- Spinophilin regulates the formation and function of dendritic spinesJ Feng
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 97:9287-92. 2000b>Spinophilin, a protein that interacts with actin and protein phosphatase-1, is highly enriched in dendritic spines...
- A protein phosphatase-1gamma1 isoform selectivity determinant in dendritic spine-associated neurabinLeigh C Carmody
Department of Molecular Physiology and Biophysics, The Center for Molecular Neuroscience, and The Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0615, USA
J Biol Chem 279:21714-23. 2004..studies from brain and muscle extracts demonstrated that PP1gamma1 selectively interacts with spinophilin and neurabin, F-actin-targeting proteins, whereas PP1beta selectively interacted with G(M)/R(GL), the striated-..
- Spinophilin facilitates dephosphorylation of doublecortin by PP1 to mediate microtubule bundling at the axonal wristStephanie L Bielas
Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
Cell 129:579-91. 2007..We find that Spinophilin, a Protein-phosphatase 1 (PP1) targeting protein, is responsible for the dephosphorylation of the MAP ..
- Distinct roles for spinophilin and neurabin in dopamine-mediated plasticityP B Allen
Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
Neuroscience 140:897-911. 2006..protein phosphatase 1 activity include interactions with the structurally related cytoskeletal elements spinophilin and neurabin, synaptic scaffolding proteins that are highly enriched in dendritic spines...
- The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphologyXiaozhou P Ryan
Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Neuron 47:85-100. 2005Neurabin and spinophilin are homologous protein phosphatase 1 and actin binding proteins that regulate dendritic spine function...
- Spinophilin/neurabin reciprocally regulate signaling intensity by G protein-coupled receptorsXinhua Wang
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9040, USA
EMBO J 26:2768-76. 2007b>Spinophilin (SPL) and neurabin (NRB) are structurally similar scaffolding proteins with several protein binding modules, including actin and PP1 binding motifs and PDZ and coiled-coil domains...
- Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptorsAshley E Brady
Department of Pharmacology, Center for Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
J Biol Chem 278:32405-12. 2003..The third intracellular loops of the alpha 2A, alpha 2B, and alpha 2C-AR subtypes interact with spinophilin, a multidomain protein that, like the three alpha 2-AR subtypes, is enriched at the basolateral surface of ..
- Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptorsQin Wang
Department of Pharmacology and Center of Molecular Neuroscience, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Science 304:1940-4. 2004..We report that the multidomain protein, spinophilin, antagonizes these multiple arrestin functions...
- The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in GlioblastomaMujeeburahiman Cheerathodi
University of Texas MD Anderson Cancer Center, Houston, Texas
Mol Cancer Res 14:1277-1287. 2016..a novel adhesion and signaling pathway comprised of the integrin αvβ8 and its intracellular binding partner, Spinophilin (Spn), which regulates glioblastoma cell invasion in the brain microenvironment...
- A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signalingPeisong Ma
Department of Medicine and Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Blood 119:1935-45. 2012..Here, we describe a novel complex comprising the scaffold protein, spinophilin (SPL), and the tyrosine phosphatase, SHP-1, and show that it can modulate platelet activation by sequestering ..
- Age-dependent targeting of protein phosphatase 1 to Ca2+/calmodulin-dependent protein kinase II by spinophilin in mouse striatumAnthony J Baucum
Department of Molecular Physiology and Biophysics, Vanderbilt Kennedy Center, Center for Molecular Neuroscience, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
PLoS ONE 7:e31554. 2012..b>Spinophilin is an F-actin- and protein phosphatase 1 (PP1)-binding protein that targets PP1 to multiple downstream ..
- RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomesJ P Palavicini
Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, FL 34987 2352, USA
Cell Death Dis 4:e667. 2013..In the present study, we found striking reduction of spinophilin protein levels when RanBP9 is overexpressed...
- Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillationDavid Y Chiang
Cardiovascular Research Institute, Baylor College of Medicine, Houston, TX, USA Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, USA Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, TX, USA
Cardiovasc Res 103:178-87. 2014..This is due to a lack of investigation into the local, rather than global, regulation of PP1 on different subcellular targets such as ryanodine receptor type 2 (RyR2), especially in AF...
- COPS5 protein overexpression increases amyloid plaque burden, decreases spinophilin-immunoreactive puncta, and exacerbates learning and memory deficits in the mouse brainRuizhi Wang
From the Section of Neurobiology, Torrey Pines Institute for Molecular Studies, Port Saint Lucie, Florida 34987
J Biol Chem 290:9299-309. 2015..Furthermore, COPS5 overexpression reduced spinophilin in both the cortex (19%, p < 0.05) and the hippocampus (20%, p < 0...
- Modulating platelet reactivity through control of RGS18 availabilityPeisong Ma
Departments of Medicine and Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA and
Blood 126:2611-20. 2015..that a critical node in the G-protein signaling network in platelets is formed by a scaffold protein, spinophilin (SPL), the tyrosine phosphatase, Src homology region 2 domain-containing phosphatase-1 (SHP-1), and the ..
- The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunitsRyan T Terry-Lorenzo
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biol Chem 277:27716-24. 2002..Immunoprecipitation of neurabin I and neurabin II/spinophilin from rat brain extracts sedimented PP1gamma1 and PP1alpha but not PP1beta...
- Cross-talk from β-adrenergic receptors modulates α2A-adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilinChristopher Cottingham
From the Departments of Cell, Developmental, and Integrative Biology and
J Biol Chem 288:29193-205. 2013..from the AR literature and our own extensive studies on regulation of α2AARs by the scaffolding protein spinophilin have illuminated a potential novel mechanism for cross-talk from β to α2ARs...
- Differential association of postsynaptic signaling protein complexes in striatum and hippocampusAnthony J Baucum
Department of Molecular Physiology and Biophysics, Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Neurochem 124:490-501. 2013..calcium/calmodulin-dependent protein kinase II (CaMKII), a highly abundant serine/threonine kinase, and spinophilin, a F-actin and protein phosphatase 1 (PP1) binding protein, were significantly lower in striatal extracts, as ..
- Spinophilin as a novel regulator of M3 muscarinic receptor-mediated insulin release in vitro and in vivoInigo Ruiz de Azua
Molecular Signaling Section, Mouse Metabolic Core Facility, Laboratory of Bioorganic Chemistry, NIH NIDDK, Bldg 8A, Rm B1A 05, 8 Center Dr MSC 0810 Bethesda, MD 20892 0810, USA
FASEB J 26:4275-86. 2012b>Spinophilin (SPL), a multidomain scaffolding protein known to modulate the activity of different G-protein-coupled receptors, regulates various central nervous system (CNS) functions...
- Spinophilin is required for normal morphology, Ca(2+) homeostasis and contraction but dispensable for β-adrenergic stimulation of adult cardiomyocytesDaria Petzhold
Max Delbrück Center for Molecular Medicine MDC, Robert Rossle Str 10, 13092, Berlin, Germany
J Muscle Res Cell Motil 32:243-8. 2011b>Spinophilin (SPN) is a ubiquitously expressed scaffolding protein that interacts through several binding modules with a variety of target proteins...
- Spinophilin regulates central angiotensin II-mediated effect on blood pressureAndrey C da Costa Goncalves
Leibniz Institute for Molecular Pharmacology, Berlin, Germany
J Mol Med (Berl) 89:1219-29. 2011..The underlining molecular mechanisms are largely unknown. Spinophilin (SPL) is a regulator of G protein-coupled receptor signaling...
- Spinophilin acts as a tumor suppressor by regulating Rb phosphorylationIrene Ferrer
Experimental Therapeutics Programme, Instituto de Biomedicina de Sevilla HUVR, Sevilla, Spain
Cell Cycle 10:2751-62. 2011The scaffold protein Spinophilin (SPN) is a regulatory subunit of phosphatase1a located at 17q21.33...
- Role of the multidomain protein spinophilin in blood pressure and cardiac function regulationAndrey C da Costa-Goncalves
Max Delbruck Center for Molecular Medicine, Berlin, Germany
Hypertension 52:702-7. 2008b>Spinophilin controls intensity/duration of G protein-coupled receptor signaling and thereby influences synaptic activity. We hypothesize that spinophilin affects blood pressure through central mechanisms...
- Spinophilin loss contributes to tumorigenesis in vivoIrene Ferrer
Experimental Therapeutics Program, Spanish National Cancer Research Center, Madrid, Spain
Cell Cycle 10:1948-55. 2011The scaffold protein spinophilin (SPN, PPP1R9B) is a regulatory subunit of phosphatase-1a located at 17q21.31...
- Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1)Soumitra Rajagopal
Molecular Oncology Research Institute, Tufts Medical Center, Tufts UniversitySackler School of Graduate Biomedical Sciences, Boston, Massachusetts 02111, USA
J Biol Chem 285:18060-71. 2010..express at least two Tiam1-interacting proteins, insulin receptor substrate protein 53 kDa (IRSp53) and spinophilin. We used fluorescent resonance energy transfer (FRET) to measure localized Rac activation associated with ..
- Knockout of spinophilin, an endogenous antagonist of arrestin-dependent alpha2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differencesSubodh Nag
Department of Neurobiology and Neurotoxicology, Meharry Medical College, 1005 D B Todd Boulevard, Nashville, TN 37208, USA
Behav Brain Res 197:457-61. 2009..Agonist activation of the receptor enhances its association with spinophilin that antagonizes arrestin functions both by diminishing receptor phosphorylation by G-protein-coupled receptor ..
- Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8Seiji Fujii
Department of Bio Science, Faculty of Bio Science, Nagahama Institute of Bio Science and Technology, Nagahama shi, Shiga, Japan
Biochem Biophys Res Commun 377:200-4. 2008..Here, we identified spinophilin (SPL) as an RGS8-interacting protein...
- Multiple actions of spinophilin regulate mu opioid receptor functionJoanna J Charlton
Department of Pharmacology, University of Crete, 71409 Heraklion, Crete, Greece
Neuron 58:238-47. 2008b>Spinophilin, a dendritic spine-enriched scaffold protein, modulates synaptic transmission via multiple functions mediated by distinct domains of the protein. Here, we show that spinophilin is a key modulator of opiate action...
- Spinophilin participates in information transfer at immunological synapsesOna Bloom
Department of Cell Biology, Ludwig Institute for Cancer Research, New Haven, CT 06520, USA
J Cell Biol 181:203-11. 2008..One such protein is spinophilin, a scaffolding protein of neuronal dendritic spines that regulates synaptic transmission...
- Protein kinase A phosphorylation of spinophilin modulates its interaction with the alpha 2A-adrenergic receptor (AR) and alters temporal properties of alpha 2AAR internalizationJianmin Xu
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Biol Chem 283:14516-23. 2008b>Spinophilin plays critical roles in regulating trafficking and signaling of the alpha(2)-adrenergic receptor (AR) both in vitro and in vivo (Wang, Q., Zhao, J., Brady, A. E., Feng, J., Allen, P. B., Lefkowitz, R. J., Greengard, P...
- Neurabin contributes to hippocampal long-term potentiation and contextual fear memoryLong Jun Wu
Department of Physiology, University of Toronto, Toronto, Onatrio, Canada
PLoS ONE 3:e1407. 2008..Our results indicate that neurabin regulates contextual fear memory and LTP in hippocampal CA1 pyramidal neurons...
- Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathwaysKen Uematsu
Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka, Japan
J Neurochem 95:1642-52. 2005b>Spinophilin is a protein phosphatase-1 (PP-1)- and actin-binding protein that is enriched in dendritic spines...
- Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5)Marie Futter
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:3489-94. 2005b>Spinophilin is a protein that binds to protein phosphatase-1 and actin and modulates excitatory synaptic transmission and dendritic spine morphology...
- Doublecortin association with actin filaments is regulated by neurabin IIMiki Tsukada
Max Planck Institute for Experimental Endocrinology, Feodor Lynen Strasse 7, D 30625 Hannover, Germany
J Biol Chem 280:11361-8. 2005..When cells were co-transfected with neurabin II, a protein that binds F-actin as well as Dcx, GFP-Dcx and to an even greater extent GFP-Dcx(S47E) became ..
- Identification of neurabin II as a novel doublecortin interacting proteinMiki Tsukada
Max Planck Institute for Experimental Endocrinology, Feodor Lynen Strasse 7, Hannover 30625, Germany
Mech Dev 120:1033-43. 2003..Using a yeast two-hybrid screen with Dcx as bait, we have isolated neurabin II/spinophilin, an F-actin binding protein known to play a role in dendritic spine formation...
- Impaired conditioned taste aversion learning in spinophilin knockout miceC A Stafstrom-Davis
Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4340 USA
Learn Mem 8:272-8. 2001Plasticity in dendritic spines may underlie learning and memory. Spinophilin, a protein enriched in dendritic spines, has the properties of a scaffolding protein and is believed to regulate actin cytoskeletal dynamics affecting dendritic ..