Pparg

Summary

Gene Symbol: Pparg
Description: peroxisome proliferator activated receptor gamma
Alias: Nr1c3, PPAR-gamma, PPAR-gamma2, PPARgamma, PPARgamma2, peroxisome proliferator-activated receptor gamma, nuclear receptor subfamily 1 group C member 3, peroxisome proliferator activated receptor gamma 2, peroxisome proliferator activated receptor gamma 4
Species: mouse

Top Publications

  1. pmc Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Nature 447:1116-20. 2007
  2. ncbi Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes 53:336-46. 2004
  3. pmc Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Frederick, Maryland 20892, USA
    J Clin Invest 111:737-47. 2003
  4. pmc De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis
    Mohamed Sabry Hamza
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
    PLoS ONE 4:e4907. 2009
  5. pmc The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
    Luisa Klotz
    Institutes of Molecular Medicine and Experimental Immunology, Department of Neurology, University of Bonn, Bonn 53105, Germany
    J Exp Med 206:2079-89. 2009
  6. ncbi mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer
    P Tontonoz
    Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1224-34. 1994
  7. pmc PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale
    Martina I Lefterova
    Institute for Diabetes, Obesity, and Metabolism, and Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 22:2941-52. 2008
  8. pmc Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes
    Hong Ping Guan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 19:453-61. 2005
  9. doi Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ
    Eve Draper
    Immunomodulation Research Group, School of Biotechnology, Dublin City University, Dublin 9, Ireland
    J Nutr Biochem 22:784-90. 2011
  10. ncbi IL-1 and LPS but not IL-6 inhibit differentiation and downregulate PPAR gamma in brown adipocytes
    Tomas Mracek
    Institute of Physiology and Center for Integrated Genomics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Cytokine 26:9-15. 2004

Research Grants

  1. TRANSCRIPTIONAL CONTROL OF COLON CANCER THROUGH PPARY
    Bruce Spiegelman; Fiscal Year: 2004
  2. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
  3. PPARGamma in Sepsis-Induced Immunosuppression
    Raju Reddy; Fiscal Year: 2006
  4. Hypoxia-Induced Mitogenic Factor in Perinatal Lung
    Dechun Li; Fiscal Year: 2006
  5. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
  6. Regulation of syndecan 1 in by n-3 PUFA
    IRIS EDWARDS; Fiscal Year: 2009
  7. Seasonal Bone Loss in Mice
    Clifford Rosen; Fiscal Year: 2008
  8. Genomic determinants of leptin expression
    Evan Rosen; Fiscal Year: 2008
  9. Muscle PPARgamma and Metabolic Regulation
    Andrew Norris; Fiscal Year: 2008
  10. Contribution of ATGL in skeletal muscle to lipid metabolism and insulin action
    ERIN KERSHAW; Fiscal Year: 2008

Detail Information

Publications211 found, 100 shown here

  1. pmc Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Nature 447:1116-20. 2007
    ..Using mice with macrophage-specific deletion of the peroxisome proliferator activated receptor-gamma (PPARgamma), we show here that PPARgamma is required for maturation of alternatively activated macrophages...
  2. ncbi Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1
    Li Jun Ma
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes 53:336-46. 2004
    ..Inhibition of PAI-1 might provide a novel anti-obesity and anti-insulin resistance treatment...
  3. pmc Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
    Kimihiko Matsusue
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Frederick, Maryland 20892, USA
    J Clin Invest 111:737-47. 2003
    To elucidate the function of PPARgamma in leptin-deficient mouse (ob/ob) liver, a PPARgamma liver-null mouse on an ob/ob background, ob/ob-PPARgamma(fl/fl)AlbCre(+), was produced using a floxed PPARgamma allele, PPARgamma(fl/fl), and Cre ..
  4. pmc De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis
    Mohamed Sabry Hamza
    Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore
    PLoS ONE 4:e4907. 2009
    ..in these disorders is the nuclear hormone transcription factor peroxisome proliferator-activated receptor-gamma (PPARgamma)...
  5. pmc The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity
    Luisa Klotz
    Institutes of Molecular Medicine and Experimental Immunology, Department of Neurology, University of Bonn, Bonn 53105, Germany
    J Exp Med 206:2079-89. 2009
    ..We identify the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) as a key negative regulator of human and mouse Th17 differentiation...
  6. ncbi mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer
    P Tontonoz
    Dana Farber Cancer Institute, Boston, Massachusetts
    Genes Dev 8:1224-34. 1994
    ....
  7. pmc PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale
    Martina I Lefterova
    Institute for Diabetes, Obesity, and Metabolism, and Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 22:2941-52. 2008
    Peroxisome proliferator-activated receptor gamma(PPARgamma), a nuclear receptor and the target of anti-diabetic thiazolinedione drugs, is known as the master regulator of adipocyte biology...
  8. pmc Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes
    Hong Ping Guan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 19:453-61. 2005
    Peroxisome proliferator-activated receptor gamma (PPARgamma) is the master regulator of adipogenesis as well as the target of thiazolidinedione (TZD) antidiabetic drugs...
  9. doi Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ
    Eve Draper
    Immunomodulation Research Group, School of Biotechnology, Dublin City University, Dublin 9, Ireland
    J Nutr Biochem 22:784-90. 2011
    ..Thus n-3 PUFA activate PPARγ and interact with NF-κB in DC. However, the anti-inflammatory effects of EPA and DHA on DCs are independent of PPARγ...
  10. ncbi IL-1 and LPS but not IL-6 inhibit differentiation and downregulate PPAR gamma in brown adipocytes
    Tomas Mracek
    Institute of Physiology and Center for Integrated Genomics, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Cytokine 26:9-15. 2004
    ..5-10-fold decrease in PPARgamma mRNA...
  11. pmc PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
    Ni Huiping Son
    Division of Preventive Medicine and Nutrition, Columbia University, New York, New York 10032, USA
    J Clin Invest 120:3443-54. 2010
    ....
  12. ncbi TAZ, a transcriptional modulator of mesenchymal stem cell differentiation
    Jeong Ho Hong
    Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E18 580, Cambridge, MA 02139, USA
    Science 309:1074-8. 2005
    ..Two key transcription factors, Runx2 and peroxisome proliferator-activated receptor gamma (PPARgamma), drive MSCs to differentiate into either osteoblasts or adipocytes, respectively...
  13. pmc PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice
    Takeshi Kanda
    Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Invest 119:110-24. 2009
    ..As PPARgamma, a transcriptional regulator of energy balance, is expressed in endothelial cells, we set out to investigate the ..
  14. pmc FoxO1 haploinsufficiency protects against high-fat diet-induced insulin resistance with enhanced peroxisome proliferator-activated receptor gamma activation in adipose tissue
    Jane J Kim
    Department of Pediatrics, University of California at San Diego, La Jolla, California, USA
    Diabetes 58:1275-82. 2009
    ..Although the FoxO1 isoform is known to play a key role in adipogenesis, its physiological role in differentiated adipose tissue remains unclear...
  15. pmc Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism
    Dongning Pan
    Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 137:73-86. 2009
    ..These findings reveal an unexpected physiological role for twist-1 in the maintenance of energy homeostasis and have important implications for understanding metabolic control and metabolic diseases...
  16. pmc The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop
    Ken Ichi Wakabayashi
    Genome Science Division, University of Tokyo, Tokyo, Japan
    Mol Cell Biol 29:3544-55. 2009
    ..We also show that PPAR gamma targets PPAR gamma2 and promotes its gene expression through H4K20 monomethylation...
  17. pmc Comparative epigenomic analysis of murine and human adipogenesis
    Tarjei S Mikkelsen
    Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA
    Cell 143:156-69. 2010
    ..We also utilize the close relationship between open chromatin marks and transcription factor motifs to identify and validate PLZF and SRF as regulators of adipogenesis...
  18. ncbi TNF alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression
    H Xing
    Affymax Research Institute, Santa Clara, California 95051, USA
    Endocrinology 138:2776-83. 1997
    ..Peroxisome proliferator-activated receptor gamma (PPARgamma) is a positive regulator of adipogenesis, whereas preadipocyte factor 1 (Pref-1) inhibits adipocyte ..
  19. ncbi Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes
    Yoshikazu Tamori
    Division of Diabetes, Digestive, and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Diabetes 51:2045-55. 2002
    ..These results suggest that PPAR-gamma plays an important role in mature 3T3-L1 adipocytes at least in part by maintaining the expression of genes that confer the characteristics of mature adipocytes...
  20. pmc Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles
    Willem J de Lange
    Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 35:1-4. 2008
    ..Careful experimental design is required therefore to ensure that tissue-specific knockouts are indeed tissue specific and that appropriate controls are used to compare strains...
  21. doi Deletion of PPAR gamma in alveolar macrophages is associated with a Th-1 pulmonary inflammatory response
    Anagha Malur
    Department of Internal Medicine, Division of Pulmonary and Critical Care and Sleep Medicine, East Carolina University, Greenville, NC 27834, USA
    J Immunol 182:5816-22. 2009
    Peroxisome proliferator-activated receptor gamma (PPARgamma) is constitutively expressed at high levels in healthy alveolar macrophages, in contrast to other tissue macrophages and blood monocytes...
  22. pmc Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma
    Nicholas P Evans
    Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Nutr 140:515-21. 2010
    ..Mice lacking PPARgamma in immune and epithelial cells and PPARgamma-expressing littermates were fed either control or CLA-supplemented (..
  23. pmc Regulation of PPAR gamma gene expression by nutrition and obesity in rodents
    A Vidal-Puig
    Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215, USA
    J Clin Invest 97:2553-61. 1996
    ..The potential for regulation of PPAR gamma gene expression in vivo is unknown...
  24. ncbi Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    Oksana Gavrilova
    Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:34268-76. 2003
    Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that mediates the antidiabetic effects of thiazolidinediones...
  25. ncbi Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-gamma and attenuates the oxidative burst
    A M Johann
    Institute of Biochemistry I, Faculty of Medicine, Johann Wolfgang Goethe University Frankfurt, Theodor Stern Kai 7, Frankfurt 60590, Germany
    Cell Death Differ 13:1533-40. 2006
    ..EMSA analysis demonstrated an immediate activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) following supplementation of AC to macrophages...
  26. ncbi Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis
    Yuan Li Zhang
    Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Biol Chem 281:37603-15. 2006
    ..By contrast, hepatic levels of peroxisomal proliferator-activated receptor 2 (PPARgamma2) mRNA and protein were specifically increased in apoB/BATless mice, as were hepatic mRNA levels of two targets ..
  27. pmc Toll-like receptor 4 mediates cross-talk between peroxisome proliferator-activated receptor gamma and nuclear factor-kappaB in macrophages
    Brian M Necela
    Department of Cancer Biology, Mayo Clinic Comprehensive Cancer Center, Jacksonville, FL 32224, USA
    Immunology 125:344-58. 2008
    The peroxisome proliferator-activated receptor gamma (PPARgamma) is expressed in macrophages and plays an important role in suppressing the inflammatory response...
  28. pmc The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation
    Koen M A Dreijerink
    University Medical Center Utrecht, Department of Physiological Chemistry, Utrecht, The Netherlands
    Mol Cell Biol 29:5060-9. 2009
    ..As MEN1 patients frequently develop lipomas and peroxisome proliferator-activated receptor gamma (PPARgamma) is expressed in several MEN1-related tumor types, we investigated regulation of PPARgamma activity by menin...
  29. pmc Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression
    Xiwu Chen
    Department of Medicine, Division of Nephrology, Medical Center North B3109, Vanderbilt University, Nashville, TN 37232, USA
    Mol Cell Biol 30:3048-58. 2010
    ..kinase (ERK), which leads to reduced activation of peroxisome proliferator-activated receptor gamma (PPARgamma), a transcription factor that positively regulates Cav-1 expression...
  30. pmc Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}
    Ui Hyun Park
    Department of Bioscience and Biotechnology, BK21 Graduate Program, Sejong University, 98 Kunja dong, Kwangjin gu, Seoul 143 747, Korea
    J Biol Chem 286:1354-63. 2011
    ..These results suggest that members of the additional sex comb-like family provide complex regulation of adipogenesis via differential modulation of PPARγ activity...
  31. pmc The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor γ through spatial relocalization at helix 7 of its ligand-binding domain
    Elke Burgermeister
    Department of Medicine II, Universitatsklinikum Mannheim, Universitat Heidelberg, Mannheim, Germany
    Mol Cell Biol 31:3497-510. 2011
    ..These results suggest a novel mechanism of PPARγ regulation by which Ras/MAPK inhibitors act as scaffold proteins that sequester and sensitize PPARγ to ligands, limiting proliferation of gastric epithelial cells...
  32. ncbi Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice
    Susanne Neschen
    Howard Hughes Medical Institute, Yale Medical School, P O Box 9812, New Haven, CT 06536 8012, USA
    Diabetes 55:924-8. 2006
    ..These data suggest that fish oil is a naturally occurring potent regulator of adiponectin secretion in vivo and that it does so through a PPARgamma-dependent and PPARalpha-independent manner in epididymal fat.
  33. ncbi The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma
    Olivier Van Beekum
    Department of Metabolic and Endocrine Diseases, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands
    Endocrinology 149:1840-9. 2008
    The transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) plays a key role in the regulation of lipid and glucose metabolism in adipocytes, by regulating their differentiation, maintenance, and function...
  34. doi PPARgamma1-induced caveolin-1 enhances cholesterol efflux and attenuates atherosclerosis in apolipoprotein E-deficient mice
    Qin Hu
    Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, China
    J Vasc Res 47:69-79. 2010
    ..We investigate the effects of Cav-1 on cholesterol efflux in RAW264.7 infected with AdPPARgamma1 and whether Cav-1 could attenuate established atherosclerotic lesions in PPARgamma1-treated apoE-deficient mice...
  35. ncbi Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity
    Z Wu
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Mol Cell 3:151-8. 1999
    ..Fibroblasts from C/EBP alpha(-/-) mice undergo adipose differentiation through expression and activation of PPAR gamma, though several clear defects are apparent...
  36. pmc Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
    Weimin He
    Departments of Medicine and Biology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 100:15712-7. 2003
    ..Targeted deletion of PPARgamma in adipose tissue resulted in marked adipocyte hypocellularity and hypertrophy, elevated levels of plasma free ..
  37. doi Vascular PPARgamma controls circadian variation in blood pressure and heart rate through Bmal1
    Ningning Wang
    Department of Internal Medicine, University of Utah, Salt Lake City, UT 84132, USA
    Cell Metab 8:482-91. 2008
    Thiazolidinediones (TZDs) are PPARgamma activators that exhibit vasculoprotective properties. To determine the vascular function of PPARgamma, we analyzed Tie2Cre/flox and SM22Cre/flox mice...
  38. pmc SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis
    Russell R Nofsinger
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:20021-6. 2008
    ..Collectively, our results demonstrate that SMRT-RID-dependent repression is a key determinant of the adipogenic set point as well as an integrator of glucose metabolism and whole-body metabolic homeostasis...
  39. doi The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface
    Sami Heikkinen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch, France
    Cell Metab 9:88-98. 2009
    The metabolic impact of the common peroxisome proliferator-activated receptor gamma isoform 2 (PPARgamma2) variant Pro12Ala in human populations has been widely debated...
  40. pmc Disruption of PPARgamma signaling results in mouse prostatic intraepithelial neoplasia involving active autophagy
    M Jiang
    Department of Urologic Surgery, A 1302 MCN, Vanderbilt University Medical Center, Nashville, TN 37232 2765, USA
    Cell Death Differ 17:469-81. 2010
    ..We selectively knocked down PPARgamma2 isoform in wild-type mouse prostatic epithelial cells and examined the consequences of this in a tissue ..
  41. doi Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance
    Rajesh H Amin
    Department of Pathology and the Center for Integrative Metabolic and Endocrine Research, Wayne State University Schoolof Medicine, Detroit, MI 48201, USA
    Am J Physiol Endocrinol Metab 298:E28-37. 2010
    ..The role muscle PPARgamma plays in metabolic regulation and in mediating the antidiabetic effects of the thiazolidinediones is not ..
  42. pmc Immunoregulatory actions of epithelial cell PPAR gamma at the colonic mucosa of mice with experimental inflammatory bowel disease
    Saroj K Mohapatra
    Nutritional Immunology and Molecular Nutrition Laboratory, Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America
    PLoS ONE 5:e10215. 2010
    ..The objective of this study was to investigate the effect of targeted deletion of PPAR gamma in IEC on progression of experimental inflammatory bowel disease (IBD).
  43. ncbi Selective intranuclear redistribution of PPAR isoforms by RXR alpha
    Taro E Akiyama
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 16:707-21. 2002
    ..of the GFP-PPARm gamma isoform characterized by a reticulated pattern of the green fluorescent label for PPAR gamma within the nucleus, but not in nucleoli, and a heightened concentration of the fluorescent label surrounding ..
  44. pmc Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma
    Anna Foryst-Ludwig
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS Genet 4:e1000108. 2008
    ..we investigated its molecular interaction with a master regulator of insulin signaling/glucose metabolism, the PPARgamma, in vitro and in high-fat diet (HFD)-fed ERbeta -/- mice (betaERKO) mice...
  45. pmc MCP-1 (monocyte chemotactic protein-1)-induced protein, a recently identified zinc finger protein, induces adipogenesis in 3T3-L1 pre-adipocytes without peroxisome proliferator-activated receptor gamma
    Craig W Younce
    Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida 32816, USA
    J Biol Chem 284:27620-8. 2009
    ..proteins (C/EBP) beta, C/EBPdelta, and C/EBPalpha and peroxisome proliferator-activated receptor gamma (PPARgamma)...
  46. doi PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 401:313-8. 2010
    ..PPARγ activation seems to be involved in KD-induced hypofibrinolysis by augmenting PAI-1 gene expression in the fatty liver...
  47. pmc Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1
    Qing Qing Wu
    Department of Internal Medicine, Nephrology Division, UT Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 300:F1180-92. 2011
    ..Although Nrf2-dependent increases in HO-1 have been described, our data suggest that BARD's effects on tubular and leukocyte HO-1 during ischemic AKI may be Nrf2 independent. We also found that BARD ameliorated cisplatin nephrotoxicity...
  48. doi PPARγ stabilizes HO-1 mRNA in monocytes/macrophages which affects IFN-β expression
    Andreas von Knethen
    Institute of Biochemistry I Pathobiochemistry, Faculty of Medicine, Goethe University Frankfurt, 60590 Frankfurt, Theodor Stern Kai 7, Germany
    Free Radic Biol Med 51:396-405. 2011
    ..These data identified a so far unappreciated role of PPARγ in stabilizing HO-1 mRNA, thus, contributing to the expression of the HO-1 target gene IFN-β...
  49. pmc Beta-arrestin-1 protein represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-gamma (PPARgamma)
    Le Nan Zhuang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Tongji University, Shanghai 200092, China
    J Biol Chem 286:28403-13. 2011
    ..Therefore, our findings not only reveal a molecular mechanism for the modulation of obesity by β-arrestin-1 but also suggest a potential tactical approach against obesity and its associated metabolic disorders...
  50. doi Sirtuin 1 promotes Th2 responses and airway allergy by repressing peroxisome proliferator-activated receptor-γ activity in dendritic cells
    Agnieszka Legutko
    Laboratory of Cellular and Molecular Physiology, Interdisciplinary Cluster for Applied Genoproteomics GIGA Research, University of Liege, Liège B 4000, Belgium
    J Immunol 187:4517-29. 2011
    ..This study reveals a previously unappreciated function of sirtuin 1 in the regulation of DC function and Th2 responses, thus shedding new light on our current knowledge on the regulation of inflammatory processes by sirtuins...
  51. doi Poly(ADP-ribose)polymerase-1 (PARP1) controls adipogenic gene expression and adipocyte function
    Suheda Erener
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, 8057 Zurich, Switzerland
    Mol Endocrinol 26:79-86. 2012
    ..Together, our study identifies PARP1 as a critical regulator of PPARγ2-dependent gene expression with implications in adipocyte function and obesity-related disease models...
  52. doi The influence of peroxisome proliferator-activated receptor γ(1) during differentiation of mouse embryonic stem cells to neural cells
    Ali Ghoochani
    Department of Cell and Molecular Biology, Cell Science Research Center, Royan Institute for Animal Biotechnology, ACECR, Isfahan, Iran
    Differentiation 83:60-7. 2012
    ..Here, we have demonstrated the stage dependent role of PPARγ modulation on neural differentiation of mESCs by retinoic acid treatment for the first time...
  53. doi Angiotensin-(1-7) Mas-receptor deficiency decreases peroxisome proliferator-activated receptor gamma expression in adipocytes
    Erica Guilhen Mario
    Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
    Peptides 33:174-7. 2012
    ..The data suggest that the lack of angiotensin-(1-7) action through Mas receptor alters the response of adipocytes to insulin action. These effects might be related to decreased expression of PPARγ...
  54. pmc Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    Frederic Picard
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 429:771-6. 2004
    ..As a reduction in fat is sufficient to extend murine lifespan, our results provide a possible molecular pathway connecting calorie restriction to life extension in mammals...
  55. pmc PPAR gamma is highly expressed in F4/80(hi) adipose tissue macrophages and dampens adipose-tissue inflammation
    Josep Bassaganya-Riera
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, 24061, United States
    Cell Immunol 258:138-46. 2009
    ..Hence, we hypothesized that F4/80(hi) and F4/80(lo) ATM differentially express PPAR gamma. This study phenotypically and functionally characterizes F4/80(hi) and F4/80(lo) ATM subsets during obesity...
  56. pmc Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha
    E Hu
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 92:9856-60. 1995
    ..to transdifferentiate into mature adipocytes by the ectopic expression of two adipogenic transcription factors, PPAR gamma and C/EBP alpha...
  57. pmc Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha
    P Tontonoz
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
    Nucleic Acids Res 22:5628-34. 1994
    ..the ARF6 complex as a heterodimer of the retinoid X receptor alpha (RXR alpha) and the murine peroxisome proliferator activated receptor gamma (PPAR gamma)...
  58. ncbi Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2
    A Elbrecht
    Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    Biochem Biophys Res Commun 224:431-7. 1996
    We describe the molecular cloning and expression of cDNAs encoding human PPAR gamma 1 and PPAR gamma 2. Our sequences are distinct from the published sequence at 3 positions, resulting in nonconservative amino acid substitutions...
  59. pmc Conditional disruption of the peroxisome proliferator-activated receptor gamma gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages and reduced cholesterol efflux
    Taro E Akiyama
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:2607-19. 2002
    Disruption of the peroxisome proliferator-activated receptor gamma (PPAR gamma) gene causes embryonic lethality due to placental dysfunction...
  60. pmc PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages
    John S Welch
    Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla 92093 0651, USA
    Proc Natl Acad Sci U S A 100:6712-7. 2003
    Natural and synthetic agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma) regulate adipocyte differentiation, glucose homeostasis, and inflammatory responses...
  61. pmc Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation
    Gaetane Woerly
    Institut National de la Sante et de la Recherche Medicale INSERM, U547 IFR17, Institut Pasteur de Lille, France
    J Exp Med 198:411-21. 2003
    ..Thus, PPAR-alpha and -gamma (co)agonists might be of therapeutic interest for the regulation of allergic or inflammatory reactions by targeting both regulatory and effector cells involved in the immune response...
  62. ncbi Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways
    Paul Dowell
    Biological Chemistry and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 278:45485-91. 2003
    ..Foxo1 antagonized PPARgamma activity and vice versa indicating that these transcription factors functionally interact in a reciprocal ..
  63. pmc Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis
    Evan D Rosen
    Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Mol Cell Biol 23:7222-9. 2003
    The nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) is an important regulator of lipid and glucose homeostasis and cellular differentiation...
  64. ncbi Rosiglitazone induction of Insig-1 in white adipose tissue reveals a novel interplay of peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein in the regulation of adipogenesis
    Heidi R Kast-Woelbern
    Department of Molecular and Cell Biology, Ligand Pharmaceuticals, Inc, San Diego, California 92121, USA
    J Biol Chem 279:23908-15. 2004
    ..We demonstrated that Insig-1 is regulated by peroxisome proliferator-activated receptor gamma (PPARgamma) providing a link between insulin sensitization/glucose homeostasis and lipid homeostasis...
  65. ncbi Transcriptional activity of peroxisome proliferator-activated receptor gamma is modulated by SUMO-1 modification
    Takayuki Ohshima
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 279:29551-7. 2004
    ..Sumoylation of PPARgamma mainly occurs at a lysine residue within the activation function 1 domain...
  66. pmc Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor
    Nunciada Salma
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Mol Cell Biol 24:4651-63. 2004
    ..activators, polymerase II (Pol II), and general transcription factors (GTFs) initially occurred at the inducible PPARgamma2 promoter in the absence of SWI/SNF function...
  67. ncbi Transcription suppression of peroxisome proliferator-activated receptor gamma2 gene expression by tumor necrosis factor alpha via an inhibition of CCAAT/ enhancer-binding protein delta during the early stage of adipocyte differentiation
    Masataka Kudo
    Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, 1 1, Seiryo cho, Aoba ku, Sendai, 980 8574 Japan
    Endocrinology 145:4948-56. 2004
    ..To clarify molecular mechanisms of TNFalpha- mediated PPARgamma2 down-regulation, we here examined the effect of TNFalpha on transcription regulation of PPARgamma2 gene ..
  68. ncbi A dominant negative peroxisome proliferator-activated receptor-gamma knock-in mouse exhibits features of the metabolic syndrome
    Bethany D Freedman
    Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Biol Chem 280:17118-25. 2005
    Peroxisome proliferator-activated receptor-gamma (PPARgamma), a member of the nuclear hormone receptor family, is a master regulator of adipogenesis...
  69. ncbi PPARgamma in endothelial cells influences high fat diet-induced hypertension
    Christopher J Nicol
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Hypertens 18:549-56. 2005
    Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands improve human hypertension...
  70. pmc Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
    Julie R Jones
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 102:6207-12. 2005
    Peroxisome proliferator-activated receptor gamma (PPARgamma) plays a crucial role in adipocyte differentiation, glucose metabolism, and other physiological processes...
  71. pmc The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform
    Gema Medina-Gomez
    Department of Clinical Biochemistry, University of Cambridge Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QR, UK
    Diabetes 54:1706-16. 2005
    ..PPARgamma exists as two isoforms, gamma1 and gamma2. PPARgamma2 is the more potent adipogenic isoform in vitro and is normally restricted to adipose tissues, where it is ..
  72. pmc Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retention
    Hui Zhang
    Department of Internal Medicine and Pediatrics, University of Utah, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 102:9406-11. 2005
    The peroxisome proliferator-activated receptor subtype gamma (PPARgamma) ligands, namely the synthetic insulin-sensitizing thiazolidinedione (TZD) compounds, have demonstrated great potential in the treatment of type II diabetes...
  73. ncbi Cdk4 promotes adipogenesis through PPARgamma activation
    Anna Abella
    INSERM U540, Equipe Avenir, F 34090 Montpellier, France
    Cell Metab 2:239-49. 2005
    ..We show that the effects of cdk4 are not limited to the control of differentiation; cdk4 also participates in adipocyte function through activation of PPARgamma.
  74. ncbi Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, P O Box 8129, 6700 EV, Wageningen, The Netherlands
    Endocrinology 147:1508-16. 2006
    ..Remarkably, in PPARalpha null mice on HFD, PPARgamma mRNA was 20-fold elevated compared with wild-type mice fed a LFD, reaching expression levels of PPARalpha in ..
  75. pmc Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease
    M Adachi
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Gut 55:1104-13. 2006
    b>Peroxisome proliferator activated receptor gamma (PPARgamma) is expressed in epithelial cells, macrophage, and T and B lymphocytes...
  76. pmc Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk
    Yihong Wan
    Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 21:1895-908. 2007
    ..While PPAR gamma is known to promote adipogenesis and lipogenesis in adipose tissue, its role in the lactating mammary gland is ..
  77. ncbi Adipose tissue-specific PPARgamma deficiency increases resistance to oxidative stress
    Weijia Luo
    Center for Environmental and Genetic Medicine, The Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, TX 7703, USA
    Exp Gerontol 43:154-63. 2008
    The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPARgamma) critically regulates adipogenesis and lipogenesis...
  78. doi Peroxisome proliferator-activated receptor gamma activation promotes infiltration of alternatively activated macrophages into adipose tissue
    Rinke Stienstra
    Nutrition, Metabolism, and Genomics Group, Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    J Biol Chem 283:22620-7. 2008
    ..The alternatively activated macrophages might play a role in peroxisome proliferator-activated receptor gamma-dependent expansion and remodeling of adipose tissue...
  79. pmc In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter
    Dhananjay Gupta
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 283:32462-70. 2008
    We reported that peroxisome proliferator-activated receptor gamma (PPARgamma) transcriptionally regulates the beta-cell differentiation factor pancreatic duodenal homeobox (PDX)-1 based on in vitro RNA interference studies...
  80. ncbi PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
    E D Rosen
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell 4:611-7. 1999
    ..Activation of one of these factors, the nuclear hormone receptor PPAR gamma, is known to promote fat cell differentiation in vitro...
  81. pmc Peroxisome proliferator-activated receptor-gamma haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis
    K Setoguchi
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Clin Invest 108:1667-75. 2001
    Peroxisome proliferator-activated receptor-gamma (PPAR gamma) controls adipogenesis and glucose metabolism. It was reported recently that PPAR gamma activation by its agonistic ligands modifies lymphocyte function...
  82. ncbi Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets
    Morihito Okada
    College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    FASEB J 16:1861-8. 2002
    ..These data reveal a new mechanism whereby PPAR-gamma activation may decrease tissue inflammation in response to an ischemic insult...
  83. ncbi Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding
    Philip D G Miles
    Department of Surgery, University of California, San Diego, USA
    Am J Physiol Endocrinol Metab 284:E618-26. 2003
    Peroxisome proliferator-activated receptor-gamma (PPARgamma) is the target receptor for thiazolidinedione (TZD) compounds, which are a class of insulin-sensitizing drugs used in the treatment of type 2 diabetes...
  84. ncbi Transcriptional repression of atherogenic inflammation: modulation by PPARdelta
    Chih Hao Lee
    Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 302:453-7. 2003
    ..PPARdelta and its ligands may thus serve as therapeutic targets to attenuate inflammation and slow the progression of atherosclerosis...
  85. ncbi Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity
    Shamina M Rangwala
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Dev Cell 5:657-63. 2003
    ..The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is highly expressed in adipose tissue and the presumed molecular target for antidiabetic thiazolidinedione ..
  86. ncbi Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor heterodimers in the absence and presence of ligand
    Jerome N Feige
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Biol Chem 280:17880-90. 2005
    ....
  87. ncbi Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice
    Sheng Zhong Duan
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Circ Res 97:372-9. 2005
    ..Further, rosiglitazone causes cardiac hypertrophy at least partially independent of PPAR-gamma in cardiomyocytes and through different mechanisms from CM-PGKO...
  88. pmc Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis
    Yatrik M Shah
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA
    Am J Physiol Gastrointest Liver Physiol 292:G657-66. 2007
    ..The present study has identified a novel protective role for macrophage PPAR-gamma in the DSS-induced IBD model. The data suggest that PPAR-gamma regulates recruitment of macrophages to inflammatory foci in the colon...
  89. pmc Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality
    Sheng Zhong Duan
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Clin Invest 117:812-22. 2007
    We rescued the embryonic lethality of global PPARgamma knockout by breeding Mox2-Cre (MORE) mice with floxed PPARgamma mice to inactivate PPARgamma in the embryo but not in trophoblasts and created a generalized PPARgamma knockout mouse ..
  90. pmc Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression
    Kai Ge
    Nuclear Receptor Biology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 28:1081-91. 2008
    ..MED1/TRAP220 subunit of Mediator is required for peroxisome proliferator-activated receptor gamma (PPARgamma)-stimulated adipogenesis of mouse embryonic fibroblasts (MEFs)...
  91. doi Identification of novel PPARgamma target genes by integrated analysis of ChIP-on-chip and microarray expression data during adipocyte differentiation
    Yutaka Nakachi
    Division of Functional Genomics and Systems Medicine, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka shi, Saitama 350 1241, Japan
    Biochem Biophys Res Commun 372:362-6. 2008
    b>PPARgamma (peroxisome proliferator-activated receptor gamma) acts as a key molecule of adipocyte differentiation, and transactivates multiple target genes involved in lipid metabolic pathways...
  92. doi Transcriptional activation of Cidec by PPARgamma2 in adipocyte
    Yoon Jin Kim
    Department of Biology, Kyung Hee University, Seoul, Republic of Korea
    Biochem Biophys Res Commun 377:297-302. 2008
    ..In the present study we investigated that the mouse Cidec transcript is regulated by PPARgamma2. After the differentiation of adipocyte, the expression pattern of Cidec was similar to that of PPARgamma2...
  93. pmc Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization
    C Guignabert
    Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford Univ School of Medicine, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1082-90. 2009
    ..is reduced in pulmonary arteries (PAs) of patients with PA hypertension (PAH), and we reported that deletion of PPARgamma in smooth muscle cells (SMCs) of transgenic mice results in PAH...
  94. doi miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARgamma expression
    Sang Yun Kim
    Institute of Molecular Biology and Genetics, Seoul National University, Kwanak gu, Seoul, Republic of Korea
    Biochem Biophys Res Commun 392:323-8. 2010
    ..In the present study, we reveal that miR-27a is involved in adipocyte differentiation by binding to the PPARgamma 3'-UTR whose sequence motifs are highly conserved in mammals...
  95. doi Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer
    Ming yue Li
    Department of Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Am J Respir Cell Mol Biol 43:674-83. 2010
    ..Our findings may also reveal the possibility of using the level of endogenous PPARγ ligands and the activities of PPARγ or PPARα as tumor markers for lung cancer...
  96. pmc Cell-specific determinants of peroxisome proliferator-activated receptor gamma function in adipocytes and macrophages
    Martina I Lefterova
    University of Pennsylvania School of Medicine, 700 CRB, 415 Curie Blvd, Philadelphia, PA 19104 6149, USA
    Mol Cell Biol 30:2078-89. 2010
    The nuclear receptor peroxisome proliferator activator receptor gamma (PPARgamma) is the target of antidiabetic thiazolidinedione drugs, which improve insulin resistance but have side effects that limit widespread use...
  97. pmc Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones
    Min Lu
    Department of Medicine, University of California San Diego UCSD, San Diego, California, USA
    Nat Med 17:618-22. 2011
    ..As PPAR-γ is also expressed in neurons, we generated mice with neuron-specific Pparg knockout (Pparg brain knockout (BKO)) to determine whether neuronal PPAR-γ signaling contributes to either weight ..
  98. doi Adult cartilage-specific peroxisome proliferator-activated receptor gamma knockout mice exhibit the spontaneous osteoarthritis phenotype
    Faezeh Vasheghani
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre
    Am J Pathol 182:1099-106. 2013
    ..In conclusion, PPARγ is a critical regulator of cartilage health, the lack of which leads to an accelerated spontaneous OA phenotype...
  99. pmc Peroxisome proliferator-activated receptor γ regulates genes involved in insulin/insulin-like growth factor signaling and lipid metabolism during adipogenesis through functionally distinct enhancer classes
    Frédérik Oger
    From INSERM UMR U1011, F 59000 Lille, France
    J Biol Chem 289:708-22. 2014
    ..Thus, PPAR utilizes both broadly active and cell type-specific enhancers to modulate the dynamic range of activation of genes involved in the adipogenic process...
  100. pmc Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
    S A Kliewer
    Salk Institute for Biological Studies, La Jolla, CA
    Proc Natl Acad Sci U S A 91:7355-9. 1994
    ..receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and -delta, respectively) from mouse...
  101. pmc Induction of peroxisome proliferator-activated receptor gamma during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPbeta, C/EBPdelta, and glucocorticoids
    Z Wu
    Department of Biochemistry, Boston University School of Medicine, Massachusetts 02118, USA
    Mol Cell Biol 16:4128-36. 1996
    ..In this report, we demonstrate that peroxisome proliferator-activated receptor gamma (PPARgamma) expression in 3T3-L1 preadipocytes is induced by MIX and DEX, suggesting that C/EBPbeta and C/EBPdelta may be ..

Research Grants23

  1. TRANSCRIPTIONAL CONTROL OF COLON CANCER THROUGH PPARY
    Bruce Spiegelman; Fiscal Year: 2004
    ..Since PPAR-gamma ligands are clinically available now, this work may provide a framework in which to contemplate new therapeutic approaches to colon cancer. ..
  2. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  3. PPARGamma in Sepsis-Induced Immunosuppression
    Raju Reddy; Fiscal Year: 2006
    ..abstract_text> ..
  4. Hypoxia-Induced Mitogenic Factor in Perinatal Lung
    Dechun Li; Fiscal Year: 2006
    ..It will utilize comprehensive promoter-reporter transfection studies, EMSA, footprinting, and overexpression studies to define the protein-DNA interactions critical to HIMF gene expression during the perinatal period. ..
  5. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
    ....
  6. Regulation of syndecan 1 in by n-3 PUFA
    IRIS EDWARDS; Fiscal Year: 2009
    ..abstract_text> ..
  7. Seasonal Bone Loss in Mice
    Clifford Rosen; Fiscal Year: 2008
    ..unreadable] Understanding the impact of circadian and circannual rhythms on the skeleton will afford greater insight into homeostatic mechanisms controlling bone maintenance. [unreadable] [unreadable] [unreadable]..
  8. Genomic determinants of leptin expression
    Evan Rosen; Fiscal Year: 2008
    ..This proposal uses a variety of innovative technologies to address this deficit, including BAC transgenesis, high-throughput DNase hypersensitivity analysis, and shRNA screening. [unreadable] [unreadable] [unreadable]..
  9. Muscle PPARgamma and Metabolic Regulation
    Andrew Norris; Fiscal Year: 2008
    ..1) Determine the contribution of muscle PPARgamma to gene expression and fuel metabolism in this tissue, particularly in dynamic response to physiologic changes...
  10. Contribution of ATGL in skeletal muscle to lipid metabolism and insulin action
    ERIN KERSHAW; Fiscal Year: 2008
    ..Evaluating the role of ATGL-mediated fat breakdown in skeletal muscle will provide important insights into the pathophysiology and treatment of obesity, insulin resistance, and related metabolic disorders. [unreadable] [unreadable]..
  11. Novel regulation of adipogenesis: agouti & melanocortins
    Randall Mynatt; Fiscal Year: 2007
    ..abstract_text> ..
  12. Novel Transcriptional Pathways in Adipogenesis
    Evan Rosen; Fiscal Year: 2007
    ..biased and unbiased screens of fat cell transcription factors in cells that lack the critical adipogenic factor PPARgamma. In this way we will isolate and characterize factors that can act downstream of PPARgamma to cause lipid ..
  13. The Role of PPAR-gamma Expression on Insulin Action
    Andrea Hevener; Fiscal Year: 2006
    ..Despite the known actions of TZDs to improve insulin sensitivity, many aspects of PPARgamma biology remain unclear...
  14. IL-10 Receptor Function in Lung Inflammation
    Donald Cohen; Fiscal Year: 2004
    ..Can IL-10 hyporesponsiveness in vivo be ameliorated by inhibition of Toll-like receptor signaling? ..
  15. IDENTIFICATION AND STUDY OF PPARgamma-REGULATED GENES
    DOROTHY SEARS; Fiscal Year: 2004
    DESCRIPTION (provided by applicant):PPARgamma is a nuclear receptor whose transcriptional activity is regulated by ligands including endogenous lipid and prostaglandin molecules and synthetic, thiazolidinedione drugs (TZDs)...
  16. C/EBPB And Mitotic Clonal Expansion During Adipogenesis
    Qi Qun Tang; Fiscal Year: 2004
    ..identify the kinase(s) that catalyzes this/these phosphorylation/s and to determine how the kinase(s) is regulated. -determine the role of C/EBP-beta in mitotic clonal expansion and how phosphorylation of C/EBP-beta affects this role...
  17. KERATOCYTE CRYSTALLIN PROTEINS AND CORNEAL TRANSPARENCY
    JAMES JESTER; Fiscal Year: 2003
    ....
  18. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  19. Oxidative Modifications in Atherogenesis
    Garret FitzGerald; Fiscal Year: 2006
    ..abstract_text> ..
  20. The impact of PPAR-gamma and estrogen receptor crosstalk on insulin action
    Andrea Hevener; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  21. Convergence of Nuclear Receptor and Forkhead Signaling
    Paul Dowell; Fiscal Year: 2004
    ..Specifically, those pathways mediated by PPARgamma, and Foxo1 in mammals and DAF-12 (worm NHR) and DAF-16 (worm forkhead factor) in C. elegans...