Ppard

Summary

Gene Symbol: Ppard
Description: peroxisome proliferator activator receptor delta
Alias: NUC-1, NUC1, Nr1c2, PPAR-beta, PPAR-delta, PPAR[b], PPARdelta, Pparb, Pparb/d, peroxisome proliferator-activated receptor delta, PPARdelta/beta, Peroxisome proliferator-activated receptor beta, nuclear hormone receptor 1, nuclear receptor subfamily 1 group C member 2
Species: mouse

Top Publications

  1. pmc Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism
    Dongning Pan
    Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 137:73-86. 2009
  2. pmc Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis
    Saravanan Kanakasabai
    Neuroscience Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Immunology 130:572-88. 2010
  3. doi PPARβ/δ activation induces enteroendocrine L cell GLP-1 production
    Mehdi Daoudi
    Universite Lille Nord de France, Lille, France
    Gastroenterology 140:1564-74. 2011
  4. ncbi The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells
    Uwe Dressel
    Institute Molecular Bioscience, St Lucia, Queensland 4072, Australia
    Mol Endocrinol 17:2477-93. 2003
  5. ncbi Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway
    Nicolas Di-Poï
    Institut de Biologie Animale, Universite de Lausanne, CH 1015, Lausanne, Switzerland
    Mol Cell 10:721-33. 2002
  6. ncbi Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics
    Nguan Soon Tan
    Center for Integrative Genomics, National Center of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne CH 1015, Switzerland
    J Biol Chem 280:18163-70. 2005
  7. pmc PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function
    Sandra Kleiner
    Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 284:18624-33. 2009
  8. pmc Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Cell Metab 7:496-507. 2008
  9. pmc Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer
    Yaacov Barak
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:303-8. 2002
  10. pmc Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome
    Toshiya Tanaka
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153 8904, Japan
    Proc Natl Acad Sci U S A 100:15924-9. 2003

Research Grants

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. pmc Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism
    Dongning Pan
    Program in Gene Function and Expression and Program in Molecular Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 137:73-86. 2009
    ..Interestingly, the nuclear receptor PPARdelta not only mediates the actions of PGC-1alpha but also regulates twist-1 expression, suggesting a negative-..
  2. pmc Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis
    Saravanan Kanakasabai
    Neuroscience Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Immunology 130:572-88. 2010
    ..In this study we show that the PPARdelta agonists GW501516 and L165041 ameliorate MOGp35-55-induced EAE in C57BL/6 mice by blocking interferon (IFN)-..
  3. doi PPARβ/δ activation induces enteroendocrine L cell GLP-1 production
    Mehdi Daoudi
    Universite Lille Nord de France, Lille, France
    Gastroenterology 140:1564-74. 2011
    ..Here, we investigated whether PPARβ/δ activation regulates L cell GLP-1 production...
  4. ncbi The peroxisome proliferator-activated receptor beta/delta agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells
    Uwe Dressel
    Institute Molecular Bioscience, St Lucia, Queensland 4072, Australia
    Mol Endocrinol 17:2477-93. 2003
    ....
  5. ncbi Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway
    Nicolas Di-Poï
    Institut de Biologie Animale, Universite de Lausanne, CH 1015, Lausanne, Switzerland
    Mol Cell 10:721-33. 2002
    ..Together, these results provide a molecular mechanism by which PPARbeta protects keratinocytes against apoptosis and may contribute to the process of skin wound closure...
  6. ncbi Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics
    Nguan Soon Tan
    Center for Integrative Genomics, National Center of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne CH 1015, Switzerland
    J Biol Chem 280:18163-70. 2005
    ..Also, they provide insight into the so far reported paradoxical effects of the application of exogenous TGF-beta1 at wound sites...
  7. pmc PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function
    Sandra Kleiner
    Cardiovascular and Metabolism Disease Area, Novartis Institutes for BioMedical Research, Inc, Cambridge, Massachusetts 02139, USA
    J Biol Chem 284:18624-33. 2009
    b>PPARdelta (peroxisome proliferator-activated receptor delta) is a regulator of lipid metabolism and has been shown to induce fatty acid oxidation (FAO)...
  8. pmc Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 5103, USA
    Cell Metab 7:496-507. 2008
    ..that in response to the Th2 cytokine interleukin-4 (IL-4), peroxisome proliferator-activated receptor delta (PPARdelta) directs expression of the alternative phenotype in Kupffer cells and adipose tissue macrophages of lean mice...
  9. pmc Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer
    Yaacov Barak
    Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:303-8. 2002
    Targeting of the nuclear prostaglandin receptor peroxisome proliferator-activated receptor delta (PPARdelta) by homologous recombination results in placental defects and frequent (>90%) midgestation lethality...
  10. pmc Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome
    Toshiya Tanaka
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153 8904, Japan
    Proc Natl Acad Sci U S A 100:15924-9. 2003
    In this study, we defined the role of peroxisome proliferator-activated receptor beta/delta (PPARdelta) in metabolic homeostasis by using subtype selective agonists...
  11. ncbi Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity
    Dae J Kim
    Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania, 16802, USA
    J Biol Chem 280:9519-27. 2005
    ..Combined, these studies provide strong evidence that PPARbeta attenuates cell proliferation by modulating PKCalpha/Raf1/MEK/ERK activity that may be due in part to reduced ubiquitin-dependent turnover of PKCalpha...
  12. pmc Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks
    Sarah K Knutson
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    EMBO J 27:1017-28. 2008
    ..Thus, Hdac3 regulates metabolism through multiple signalling pathways in the liver, and deletion of Hdac3 disrupts normal metabolic homeostasis...
  13. doi Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARbeta/delta ligand GW0742
    Z Haskova
    Biopharmaceutical Center for Excellence in Drug Discovery, GlaxoSmithKline, King of Prussia, PA, USA
    Inflamm Res 57:314-21. 2008
    ..To define the anti-inflammatory effects of PPARbeta/delta activation by use of the selective PPARbeta/delta ligand (GW0742) in a model of lipopolysaccharide (LPS)-induced pulmonary inflammation...
  14. pmc Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)
    J M Peters
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 20:5119-28. 2000
    ..These results are the first to provide in vivo evidence of significant roles for PPARbeta in development, myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation...
  15. ncbi Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    Deborah M Muoio
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:26089-97. 2002
    ..Real time quantitative PCR analyses showed that unlike in liver and heart, in mouse skeletal muscle PPAR delta is severalfold more abundant than either PPAR alpha or PPAR gamma...
  16. ncbi Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes
    Matthias Schmuth
    Department of Medicine, University of California, San Francisco, California, USA
    J Invest Dermatol 122:971-83. 2004
    ..Together, these studies indicate that PPAR-beta/delta activation stimulates keratinocyte differentiation, is anti-inflammatory, improves barrier homeostasis, and stimulates TG accumulation in keratinocytes...
  17. pmc Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development
    Nicolas Di-Poï
    Center for Integrative Genomics, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 25:1696-712. 2005
    ....
  18. ncbi Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts
    Ferhana Y Ali
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, London, UK
    Am J Respir Cell Mol Biol 34:242-6. 2006
    ..This study is the first to identify PPARbeta as a potential therapeutic target for the treatment of pulmonary hypertension, which is important because orally active PPARbeta ligands have been developed for the treatment of dyslipidemia...
  19. pmc PPARdelta regulates glucose metabolism and insulin sensitivity
    Chih Hao Lee
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:3444-9. 2006
    ..We show that PPARdelta (NR1C2) knockout mice are metabolically less active and glucose-intolerant, whereas receptor activation in db/db ..
  20. pmc PPARdelta-mediated antiinflammatory mechanisms inhibit angiotensin II-accelerated atherosclerosis
    Yasunori Takata
    Division of Endocrinology, Diabetes, and Hypertension, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 7073, USA
    Proc Natl Acad Sci U S A 105:4277-82. 2008
    Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor delta (PPARdelta) has been shown to improve insulin resistance, adiposity, and plasma HDL levels...
  21. ncbi A novel peroxisome proliferator-activated receptor delta antagonist, SR13904, has anti-proliferative activity in human cancer cells
    Nurulain T Zaveri
    SRI International, Menlo Park, CA, USA
    Cancer Biol Ther 8:1252-61. 2009
    The peroxisome proliferator-activated receptor delta (PPARdelta) is a ligand-activated, nuclear receptor transcription factor that has a documented role in glucose and lipid homeostasis...
  22. pmc Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis
    Basilia Zingarelli
    Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229, USA
    Am J Pathol 177:1834-47. 2010
    ..These data suggest that PPARδ is a crucial anti-inflammatory regulator, providing a basis for novel sepsis therapies...
  23. pmc Activation of peroxisome proliferator-activated receptor-β/-δ (PPAR-β/-δ) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes
    Lucía Serrano-Marco
    Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, University of Barcelona, Institut de Biomedicina de la UB IBUB, Barcelona, Spain
    Diabetes 60:1990-9. 2011
    ..We evaluated whether peroxisome proliferator-activated receptor (PPAR)-β/-δ prevented activation of the IL-6-STAT3-SOCS3 pathway and insulin resistance in adipocytes...
  24. pmc Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
    S A Kliewer
    Salk Institute for Biological Studies, La Jolla, CA
    Proc Natl Acad Sci U S A 91:7355-9. 1994
    ..These data suggest that tissue-specific responsiveness to peroxisome proliferators, including certain fatty acids, is in part a consequence of differential expression of multiple, pharmacologically distinct PPAR isoforms...
  25. pmc Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice
    L Michalik
    Institut de Biologie Animale, Universite de Lausanne, Batiment de Biologie, CH 1015 Lausanne, Switzerland
    J Cell Biol 154:799-814. 2001
    ..In addition and very interestingly, PPARbeta mutant primary keratinocytes show impaired adhesion and migration properties. Thus, the findings presented here reveal unpredicted roles for PPARalpha and beta in adult mouse epidermal repair...
  26. pmc Critical roles of PPAR beta/delta in keratinocyte response to inflammation
    N S Tan
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Genes Dev 15:3263-77. 2001
    ..It is shown here, by use of cultures of primary keratinocytes from wild-type and PPAR beta/delta(-/-) mice, that such signals including TNF-alpha and IFN-gamma, induce keratinocyte differentiation...
  27. ncbi Targeted disruption of peroxisomal proliferator-activated receptor beta (delta) results in distinct gender differences in mouse brain phospholipid and esterified FA levels
    Thad A Rosenberger
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 1582, USA
    Lipids 37:495-500. 2002
    ..These data suggest that PPARbeta is involved in maintaining FA and phospholipid levels in adult female mouse brain and provide strong evidence that suggests a role for PPARbeta in brain peroxisomal acyl-CoA utilization...
  28. pmc PPARdelta is a very low-density lipoprotein sensor in macrophages
    Ajay Chawla
    The Salk Institute for Biological Studies, Howard Hughes Medical Institute, La Jolla, CA 90237, USA
    Proc Natl Acad Sci U S A 100:1268-73. 2003
    ..Thus, our data reveal a pathway through which dietary triglycerides and VLDL can directly regulate gene expression in atherosclerotic lesions...
  29. ncbi Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity
    Yong Xu Wang
    Gene Expression Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 113:159-70. 2003
    In contrast to the well-established roles of PPARgamma and PPARalpha in lipid metabolism, little is known for PPARdelta in this process...
  30. ncbi Localization of PPARdelta in murine central nervous system: expression in oligodendrocytes and neurons
    John W Woods
    Department of Inflammation Research, Merck Research Laboratories, Box 2000, RY80N A43, 126 East Lincoln Avenue, Rahway, NJ 07065 USA
    Brain Res 975:10-21. 2003
    The peroxisome proliferator-activated receptors (PPARs), PPARdelta, PPARgamma and PPARalpha, comprise a subclass of the supergene family of nuclear receptors...
  31. ncbi The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing
    Nicolas Di-Poï
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, CH 1015 Lausanne, Switzerland
    J Steroid Biochem Mol Biol 85:257-65. 2003
    ..Finally, comparison of PPARbeta and Akt1 knock-out mice reveals many similarities, and suggests that the ability of PPARbeta to modulate the Akt1 pathway has significant impact during skin wound healing...
  32. ncbi Transcriptional repression of atherogenic inflammation: modulation by PPARdelta
    Chih Hao Lee
    Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 302:453-7. 2003
    ..In contrast, we found that the closely related receptor PPARdelta controls the inflammatory status of the macrophage...
  33. ncbi Peroxisome proliferator-activated receptor delta controls muscle development and oxidative capability
    Serge Luquet
    INSERM U470, Centre de Biochimie, Parc Valrose, Universite de Nice Sophia Antipolis, 06108 Nice Cedex 2, France
    FASEB J 17:2299-301. 2003
    ..The physiological functions of PPARdelta remain elusive...
  34. ncbi Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth
    Rajnish A Gupta
    Department of Medicine, The Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 6838, USA
    Nat Med 10:245-7. 2004
    ..The most prominent effect was on polyp size; mice treated with the PPAR-delta activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-delta in the regulation of intestinal adenoma growth...
  35. ncbi Peroxisome proliferator-activated receptor beta/delta regulates very low density lipoprotein production and catabolism in mice on a Western diet
    Taro E Akiyama
    Laboratory of Metabolism, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Building 37, Bethesda, MD 20892, USA
    J Biol Chem 279:20874-81. 2004
    ....
  36. ncbi Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis
    Fred S Harman
    Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Med 10:481-3. 2004
    ..We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice...
  37. pmc Regulation of muscle fiber type and running endurance by PPARdelta
    Yong Xu Wang
    Gene Expression Laboratory, Salk Institute, La Jolla, California, USA
    PLoS Biol 2:e294. 2004
    ..was achieved by targeted expression of an activated form of peroxisome proliferator-activated receptor delta (PPARdelta) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers...
  38. ncbi Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    Lihong Cheng
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Nat Med 10:1245-50. 2004
    ..We suggest that PPAR-delta is a potential therapeutic target in treating lipotoxic cardiomyopathy and other heart diseases...
  39. ncbi PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine
    Karen R Reed
    Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF103US, UK
    Oncogene 23:8992-6. 2004
    Based on recent reports that peroxisome proliferator-activated receptor delta (PPARdelta) activation promotes tumourigenesis, we have investigated the role of this protein in Apc-mediated intestinal tumourigenesis...
  40. pmc Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma
    Andrew C Li
    Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California 92093 0682, USA
    J Clin Invest 114:1564-76. 2004
    ..In concert, these findings reveal receptor-specific mechanisms by which PPARs influence macrophage cholesterol homeostasis. In the future, these mechanisms may be exploited pharmacologically to inhibit the development of atherosclerosis...
  41. ncbi PPARbeta/delta selectively induces differentiation and inhibits cell proliferation
    D J Kim
    Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Cell Death Differ 13:53-60. 2006
    ....
  42. pmc Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage
    Chih Hao Lee
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:2434-9. 2006
    ..Here, we show that, in addition to beta-oxidation and energy dissipation, activation of PPARdelta by VLDL particles induces key genes involved in carnitine biosynthesis and lipid mobilization mediated by a ..
  43. pmc PPAR delta: a dagger in the heart of the metabolic syndrome
    Grant D Barish
    Howard Hughes Medical Institute, Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099, USA
    J Clin Invest 116:590-7. 2006
    ..More recent work on the less-described PPAR isotype PPARdelta has uncovered a dual benefit for both hypertriglyceridemia and insulin resistance, highlighting the broad ..
  44. pmc Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta
    Karim Nadra
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:3266-81. 2006
    ..Altogether, this important role of PPARbeta/delta in placenta development and giant cell differentiation should be considered when contemplating the potency of PPARbeta/delta agonist as therapeutic agents of broad application...
  45. ncbi Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis
    Holly E Marin
    Department of Veterinary and Biomedical Sciences and The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Cancer Res 66:4394-401. 2006
    ..of a PPARbeta ligand causes increased small intestinal tumorigenesis in Apc(min/+) mice, PPARbeta-null (Pparb-/-) mice exhibit increased colon polyp multiplicity in colon cancer bioassays, suggesting that ligand activation ..
  46. pmc Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes
    Cécile Calléja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut Clinique de la Souris ICS, CNRS INSERM ULP, College de France, 67404 Illkirch Cedex, CU de Strasbourg, France
    Genes Dev 20:1525-38. 2006
    ....
  47. ncbi PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes
    Michael Schuler
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Physiological Genetics, Illkirch, F 67400 France
    Cell Metab 4:407-14. 2006
    ....
  48. pmc Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, 2220 Pierce Avenue, Nashville, TN 37232 2279, USA
    Proc Natl Acad Sci U S A 103:19069-74. 2006
    Peroxisome proliferator-activated receptor (PPAR) delta is a member of the nuclear hormone receptor superfamily. PPARdelta may ameliorate metabolic diseases such as obesity and diabetes...
  49. pmc Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes
    Andrew D Burdick
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Huck Institute of Life Sciences, The Pennsylvania State University, University Park 16802, United States
    Cell Signal 19:1163-71. 2007
    The functional role of peroxisome proliferator-activated receptor-beta(PPARbeta; also referred to as PPARdelta) in epidermal cell growth remains controversial...
  50. ncbi PPARdelta enhances keratinocyte proliferation in psoriasis and induces heparin-binding EGF-like growth factor
    Malgorzata Romanowska
    Department of Biology, Free University of Berlin, Berlin, Germany
    J Invest Dermatol 128:110-24. 2008
    ..exhibiting a pattern consistent with the activation of peroxisome proliferator-activated receptor delta (PPARdelta). PPARdelta itself was strongly induced in psoriasis in vivo...
  51. ncbi Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta
    Tatjana Degenhardt
    Department of Biochemistry, University of Kuopio, FIN 70211, Kuopio, Finland
    J Mol Biol 372:341-55. 2007
    ..In conclusion, PDK2, PDK3 and PDK4 are primary PPARbeta/delta target genes in humans underlining the importance of the receptor in the control of metabolism...
  52. ncbi Deficiency of PPARbeta/delta in the epidermis results in defective cutaneous permeability barrier homeostasis and increased inflammation
    Mao Qiang Man
    Department of Dermatology, University of California San Francisco and VA Medical Center San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 128:370-7. 2008
    ..human keratinocytes or murine epidermis, peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) (NR1C2) activators (1) stimulate keratinocyte differentiation; (2) decrease keratinocyte proliferation; (3) accelerate ..
  53. ncbi Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success
    Haibin Wang
    Department of Pediatrics, Division of Reproductive and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Biol Chem 282:37770-82. 2007
    ..receptor (PPAR) delta plays a central role at various stages of pregnancy, whereas maternal PPARdelta is critical to implantation and decidualization, and embryonic PPARdelta is vital for placentation...
  54. pmc Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart
    Eileen M Burkart
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:3930-9. 2007
    ....
  55. doi Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity
    Alejandro Gallardo-Soler
    Departamento de Bioquimica y Biologia Molecular y Genetica, Universidad de Extremadura Avenida de la Universidad s n, 10071 Caceres, Spain
    Mol Endocrinol 22:1394-402. 2008
    ..ArgI expression is highly responsive to agonists for PPARgamma and PPARdelta but not PPARalpha...
  56. pmc PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis
    Grant D Barish
    Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:4271-6. 2008
    ..Although the nuclear receptor PPARdelta has been implicated in both systemic lipid metabolism and macrophage inflammation, its role as a therapeutic ..
  57. pmc Quantitative expression patterns of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) protein in mice
    Elizabeth E Girroir
    Department of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, 312 Life Sciences Building, University Park, PA 16802, USA
    Biochem Biophys Res Commun 371:456-61. 2008
    ..Results from these studies demonstrate that PPARbeta/delta expression is highest in intestinal epithelium, liver, and keratinocytes, consistent with significant biological roles in these tissues...
  58. pmc Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2
    Ricardo Rodríguez-Calvo
    Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, Institut de Biomedicina de la UB IBUB and CIBERDEM Instituto de Salud Carlos III, University of Barcelona, Barcelona, Spain
    Diabetes 57:2149-57. 2008
    ..It is presently unknown whether peroxisome proliferator-activated receptor (PPAR) beta/delta activation prevents inflammation in adipocytes...
  59. pmc Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    Kihwa Kang
    Department of Genetics and Complex Diseases, Division of Biological Sciences, Harvard School of Public Health, Boston, MA 02115, USA
    Cell Metab 7:485-95. 2008
    ..adipocytes are a source of Th2 cytokines, including IL-13 and to a lesser extent IL-4, which induce macrophage PPARdelta/beta (Ppard/b) expression through a STAT6 binding site on its promoter to activate alternative activation...
  60. pmc Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression
    Weiwei Shan
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Huck Institute of Life Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Toxicol Sci 105:418-28. 2008
    ..Hepatocytes and hepatic stellate cells do not appear to directly mediate the inhibitory effects of ligand activation of PPARbeta/delta in liver, suggesting the involvement of paracrine and autocrine events mediated by hepatic cells...
  61. pmc AMPK and PPARdelta agonists are exercise mimetics
    Vihang A Narkar
    Gene Expression Laboratory, Salk Institute, La Jolla, CA 92037, USA
    Cell 134:405-15. 2008
    ..These results demonstrate that AMPK-PPARdelta pathway can be targeted by orally active drugs to enhance training adaptation or even to increase endurance ..
  62. doi Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release
    Laura Piqueras
    Fundacion Hospital Clinico Universitario de Valencia, Universidad de Valencia, Valencia, Spain
    J Leukoc Biol 86:115-22. 2009
    ..Taken together, our results show that PPARbeta/delta modulates acute inflammation in vivo and in vitro under flow by targeting the neutrophil-endothelial cell interaction...
  63. pmc High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes
    Yuquan Li
    Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd, Birmingham, AL 35294 3360, USA
    J Mol Cell Cardiol 47:536-43. 2009
    Peroxisome proliferator-activated receptor delta (PPARdelta) is an essential determinant of basal myocardial fatty acid oxidation (FAO) and bioenergetics...
  64. pmc Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) inhibits cell growth in a mouse mammary gland cancer cell line
    Jennifer E Foreman
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, 16802, United States
    Cancer Lett 288:219-25. 2010
    ..Results from this study show that proliferation of the C20 mouse mammary gland cancer cell line is inhibited by ligand activation of PPARbeta/delta due in part to increased apoptosis...
  65. pmc Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver
    Linda M Sanderson
    Nutrigenomics Consortium, TI Food and Nutrition, Nieuwe Kanaal 9A, 6709 PA Wageningen, The Netherlands
    Mol Cell Biol 29:6257-67. 2009
    ..In contrast, this is not the case for PPARalpha, revealing a novel mechanism for functional differentiation between PPARs...
  66. pmc Regulation of oligodendrocyte progenitor cell maturation by PPARδ: effects on bone morphogenetic proteins
    Maria Vittoria Simonini
    Department of Anesthesiology, University of Illinois, Chicago, IL 60612, U S A
    ASN Neuro 2:e00025. 2010
    ..In contrast, GW0742 reduced BMP2 and BMP4 mRNA levels in OPCs, with lesser effects in astrocytes. These findings demonstrate that PPARδ plays a role in OPC maturation, mediated, in part, by regulation of BMP and BMP antagonists...
  67. pmc Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo
    Malgorzata Romanowska
    Division of Experimental Medicine, University of Dundee, Dundee, United Kingdom
    PLoS ONE 5:e9701. 2010
    ..It is unclear, however, whether activation of PPARbeta/delta is sufficient to trigger psoriasis-like changes in vivo...
  68. doi Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress
    Anastasia Georgiadi
    Nutrition, Metabolism and Genomics Group, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands
    Circ Res 106:1712-21. 2010
    ..Although dietary fatty acids are a major fuel for the heart, little is known about the direct effects of dietary fatty acids on gene regulation in the intact heart...
  69. pmc Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity
    Shannon E Dunn
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
    J Exp Med 207:1599-608. 2010
    ..Collectively, these findings suggest that PPAR-delta serves as an important molecular brake for the control of autoimmune inflammation...
  70. doi PPARβ/δ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells
    David Alvarez-Guardia
    Department of Pharmacology and Therapeutic Chemistry, Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
    Biochim Biophys Acta 1811:59-67. 2011
    ..This is relevant, especially taking into account that PPARβ/δ has been postulated as a potential target in the treatment of obesity and the insulin resistance state...
  71. pmc Vascular PPARδ protects against stroke-induced brain injury
    Ke Jie Yin
    Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Arterioscler Thromb Vasc Biol 31:574-81. 2011
    ..To investigate the effects of peroxisome proliferator-activated receptor (PPAR)δ in the cerebral vasculature following stroke-induced brain injury...
  72. doi Pharmacological activation of peroxisome proliferator-activated receptor δ improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice
    H T Wu
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, ROC
    Horm Metab Res 43:631-5. 2011
    ..Thus, we suggest that pharmacological activation of PPARδ may be a new strategy for the treatment of diabetic patients with hepatic steatosis...
  73. pmc Peroxisome proliferator-activated receptor β/δ induces myogenesis by modulating myostatin activity
    Sabeera Bonala
    School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore
    J Biol Chem 287:12935-51. 2012
    ..Taken together these data revealed that PPARβ/δ is a positive regulator of skeletal muscle myogenesis, which functions through negatively modulating myostatin activity via a mechanism involving Gasp-1...
  74. ncbi PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes
    Guoliang Ding
    Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    J Mol Cell Cardiol 40:821-8. 2006
    ..However, it remains obscured if PPARdelta and its ligands exert any effect on the production of TNFalpha, thus influencing cardiac inflammatory responses...
  75. ncbi High-glucose-induced prostaglandin E(2) and peroxisome proliferator-activated receptor delta promote mouse embryonic stem cell proliferation
    Yun Hee Kim
    Department of Veterinary Physiology, College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, Korea
    Stem Cells 26:745-55. 2008
    ..Subsequently, high glucose-induced PGE(2) stimulated PPARdelta expression directly or through Akt phosphorylation indirectly through the E type prostaglandin receptor ..
  76. pmc Pharmacological activation of PPARbeta promotes rapid and calcineurin-dependent fiber remodeling and angiogenesis in mouse skeletal muscle
    Celine Gaudel
    INSERM U907, Faculté de Médecine Université de Nice Sophia Antipolis, 28 Avenue de Valombrose, Nice Cedex, France
    Am J Physiol Endocrinol Metab 295:E297-304. 2008
    ..In conclusion, the data indicate that PPARbeta activation is associated with a calcineurin-dependent effect on muscle morphology that enhances the oxidative phenotype...
  77. ncbi Localization of mouse peroxisome proliferator-activated receptor delta (Ppard) on chromosome 17 near colipase (Clps)
    R D Cohen
    Lipid Research Laboratory, West Los Angeles VA Medical Center, Building 113, Room 312, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
    Mamm Genome 7:557-8. 1996
  78. ncbi Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the li
    R A Memon
    Department of Medicine, University of California, San Francisco 94143, USA
    Endocrinology 141:4021-31. 2000
    ..Taken together, our results suggest that the effects of PPAR-gamma activators on lipid metabolism and energy homeostasis in obesity and type 2 diabetes may be partly mediated through their effects on PPAR-gamma in the liver...
  79. ncbi Roles of peroxisome proliferator-activated receptors delta and gamma in myoblast transdifferentiation
    Dorte Holst
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK 5230 Odense M, Denmark
    Exp Cell Res 288:168-76. 2003
    ..This transdifferentiation was observed in both rodent and human myoblasts. In this report, we show that PPARdelta mediates some of the effects exerted by long chain fatty acids on myogenesis and adipogenesis...
  80. ncbi Inhibition of adult liver progenitor (oval) cell growth and viability by an agonist of the peroxisome proliferator activated receptor (PPAR) family member gamma, but not alpha or delta
    Belinda Knight
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, Australia
    Carcinogenesis 26:1782-92. 2005
    ..WY14643 (PPARalpha agonist), GW501516 (PPARdelta agonist) and ciglitazone (PPARgamma agonist) were tested for their ability to modulate the behaviour of p53-..
  81. ncbi Growth of transgenic RAF-induced lung adenomas is increased in mice with a disrupted PPARbeta/delta gene
    Sabine Müller-Brüsselbach
    Institute of Molecular Biology and Tumor Research IMT, Philipps University, Marburg, Germany
    Int J Oncol 31:607-11. 2007
    ..Both the PPARbeta (also referred to as PPARdelta) and PPARgamma subtype have been reported to either attenuate or potentiate tumorigenesis in a number of ..
  82. pmc Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma-/-, PPARdelta-/-, PPARgammadelta-/-, or LXRalphabeta-/- bone marrow
    Chaitra Marathe
    Howard Hughes Medical Institute, Molecular Biology Institute and Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:214-24. 2009
    ..and LXR in Th1-biased C57BL/6 mice was tested using a bone marrow transplantation approach with PPARgamma(-/-), PPARdelta(-/-), PPARgammadelta(-/-), and LXRalphabeta(-/-) cells...
  83. pmc Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta) inhibits chemically induced skin tumorigenesis
    Moses T Bility
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, PA 16802, USA
    Carcinogenesis 29:2406-14. 2008
    ..These studies suggest that topical administration of PPARbeta/delta ligands may be useful as both a chemopreventive and/or a chemotherapeutic approach to inhibit skin cancer...
  84. ncbi Growth hormone increases mRNA levels of PPARdelta and Foxo1 in skeletal muscle of growth hormone deficient lit/lit mice
    Dong Sun Kim
    Division of Endocrinology and Metabolism, University of Virginia, VA 22903, USA
    Endocr J 56:141-7. 2009
    GH plays an important role in lipid metabolism as a partitioning hormone. PPARdelta regulates lipid oxidation in skeletal muscle and is activated by several physiological ligands including fatty acids...
  85. pmc Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis
    Xiangsheng Zuo
    Department of Clinical Cancer Prevention, Unit 1360, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Natl Cancer Inst 101:762-7. 2009
    ..Increased expression of vascular endothelial growth factor in colon tumors vs normal colon was suppressed by loss of PPAR-delta expression. These findings indicate that PPAR-delta has a crucial role in promoting colonic tumorigenesis...
  86. doi PPARδ activation promotes stratum corneum formation and epidermal permeability barrier development during late gestation
    Yan J Jiang
    Department of Veterans Affairs Medical Center, Metabolism Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 130:511-9. 2010
    ..As peroxisome proliferator-activated receptor-delta (PPARdelta) is very abundant in fetal epidermis and PPARdelta activation stimulates differentiation and permeability ..
  87. pmc PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance
    Lata Mukundan
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Nat Med 15:1266-72. 2009
    ..This increases autoantibody production and predisposes global and macrophage-specific Ppard(-/-) mice to autoimmune kidney disease, a phenotype resembling the human disease systemic lupus erythematosus...
  88. pmc Peroxisome proliferator-activated receptor β/δ activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition
    Jian Liu
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    Hypertension 57:223-30. 2011
    ....
  89. pmc Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer
    Jennifer E Foreman
    Department of Veterinary and Biomedical Sciences and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Mol Carcinog 50:884-900. 2011
    ....
  90. doi Peroxisome proliferator-activated receptor δ downregulates the expression of the receptor for advanced glycation end products and pro-inflammatory cytokines in the kidney of streptozotocin-induced diabetic mice
    Yao Jen Liang
    Department and Institute of Life Science, Fu Jen Catholic University, Taipei, Taiwan, ROC
    Eur J Pharm Sci 43:65-70. 2011
    ..Its downstream signaling may include RAGE and NF-κB pathway. Target on PPARδ will provide new meaningful therapies to patients with diabetic nephropathy...
  91. ncbi Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes
    P S Jones
    Department of Life Science, University of Nottingham, England
    Eur J Biochem 233:219-26. 1995
    ..PPAR) genes were localised to chromosome 15 (PPAR alpha), chromosome 17 (PPAR beta) and chromosome 6 (PPAR gamma)...
  92. ncbi Identification of two mPPAR related receptors and evidence for the existence of five subfamily members
    F Chen
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030
    Biochem Biophys Res Commun 196:671-7. 1993
    ..The discovery of two new forms of mPPAR and the recent cloning of hPPAR provide evidence for the existence of at least five different forms of receptor in the peroxisome proliferator activated receptor subfamily...
  93. pmc Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta
    H Lim
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    Genes Dev 13:1561-74. 1999
    ..Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARdelta, demonstrating the first reported biologic function of this receptor signaling pathway.
  94. ncbi Cloning and function of rabbit peroxisome proliferator-activated receptor delta/beta in mature osteoclasts
    H Mano
    Department of Oral Anatomy, Meikai University School of Dentistry, 1 1 Keyakidai, Sakado, Saitama 350 02, Japan
    J Biol Chem 275:8126-32. 2000
    ..homologous hybridization method, we isolated the peroxisome proliferator-activated receptor delta/beta (PPARdelta/beta) cDNA from mature rabbit osteoclasts...
  95. ncbi PPAR delta functions as a prostacyclin receptor in blastocyst implantation
    H Lim
    Division of Genetics, Brigham and Women s Hospital and Harvard Medical School, 20 Shattuck Street, Thorn 1010, Boston, MA 02115, USA
    Trends Endocrinol Metab 11:137-42. 2000
    ..Recently, a novel biological function of PPAR delta, a less studied member of the family, was observed in the mouse...
  96. ncbi Implantation and decidualization defects in prolactin receptor (PRLR)-deficient mice are mediated by ovarian but not uterine PRLR
    J Reese
    Department of Pediatrics, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66160 7338, USA
    Endocrinology 141:1872-81. 2000
    ..PRLR-/- mice had similar expression of the implantation-specific genes, LIF, amphiregulin, HB-EGF, COX-1, COX-2, PPARdelta, Hoxa-10, cyclin-D3, VEGF, and its receptors, Flk-1 and neuropilin-1...
  97. ncbi Targeted deletion of the cytosolic domain of tissue factor in mice does not affect development
    E Melis
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology VIB, KU Leuven, Leuven, B 3000, Belgium
    Biochem Biophys Res Commun 286:580-6. 2001
    ....
  98. ncbi Selective intranuclear redistribution of PPAR isoforms by RXR alpha
    Taro E Akiyama
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 16:707-21. 2002
    ..These results implicate RXR alpha in the nuclear reorganization of PPAR gamma and suggest that PPAR gamma colocalizes with RXR alpha at specific locations within the nucleus independent of added ligand...
  99. ncbi Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha
    M Carmen Carmona
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona E 08028, Spain
    J Biol Chem 277:21489-98. 2002
    ....
  100. ncbi Peroxisome proliferator-activated receptor delta activates fatty acid oxidation in cultured neonatal and adult cardiomyocytes
    Lihong Cheng
    Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Drive SW, Atlanta, GA 30310, USA
    Biochem Biophys Res Commun 313:277-86. 2004
    ..The effect of PPARalpha in regulation of cardiac fatty acid oxidation has been well characterized. Whether PPARdelta also independently regulates fatty acid oxidation in the heart remains unclear...
  101. ncbi Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells
    Hyunjung J Lim
    Department of Obstetrics and Gynecology, Washington University School of Medicine, Campus Box 8064, 4566 Scott Avenue, St Louis, Missouri 63110, USA
    Endocrinology 145:2886-95. 2004
    We previously showed that peroxisome proliferator-activated receptor delta (PPARdelta) is crucial for embryo implantation as a receptor for cyclooxygenase-2-derived prostacyclin in mice. PPARs belong to the nuclear receptor superfamily...

Research Grants7

  1. Role of the PPARb in epithelial cell proliferation
    Jeffrey Peters; Fiscal Year: 2004
    ..contribute to diseases including hyperlipidemias, atherosclerosis, obesity, diabetes and cancer, the function of PPARb has remained a mystery...
  2. Role of PPARbeta in colon carcinogenesis
    Jeffrey Peters; Fiscal Year: 2007
    ..abstract_text> ..
  3. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
    ..abstract_text> ..
  4. Poly (ADP-Ribose) synthetase in expression of endothelia
    Basilia Zingarelli; Fiscal Year: 2003
    ..abstract_text> ..
  5. Ketone Dysregulation and Muscle Insulin Resistance
    DEBORAH MUOIO; Fiscal Year: 2006
    ..abstract_text> ..
  6. Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistance
    Deborah M Muoio; Fiscal Year: 2010
    ....
  7. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..