Ppara

Summary

Gene Symbol: Ppara
Description: peroxisome proliferator activated receptor alpha
Alias: 4933429D07Rik, AW742785, Nr1c1, PPAR-alpha, PPARalpha, Ppar, peroxisome proliferator-activated receptor alpha, nuclear receptor subfamily 1 group C member 1
Species: mouse

Top Publications

  1. pmc Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    J Clin Invest 103:1489-98. 1999
  2. doi The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation
    Emma Barroso
    Department of Pharmacology and Therapeutic Chemistry, and Institut de Biomedicina de la University of Barcelona, Barcelona Spain
    Endocrinology 152:1848-59. 2011
  3. ncbi Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway
    Brian N Finck
    Center for Cardiovascular Research and Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 4:199-210. 2006
  4. doi Regulatory mechanism governing the diurnal rhythm of intestinal H+/peptide cotransporter 1 (PEPT1)
    Hirofumi Saito
    Dept of Pharmacy, Kyoto Univ Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 295:G395-402. 2008
  5. pmc Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism
    Sarah Garrido-Urbani
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e14665. 2011
  6. pmc A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
    T C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:7473-8. 1999
  7. pmc Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    J J Lehman
    Department of Medicine, and Department of Pathology, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 106:847-56. 2000
  8. pmc PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
    Ni Huiping Son
    Division of Preventive Medicine and Nutrition, Columbia University, New York, New York 10032, USA
    J Clin Invest 120:3443-54. 2010
  9. ncbi OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization
    Nathan E Wolins
    Department of Medicine, 660 S Euclid Ave, Campus Box 8127, St Louis, MO 63110, USA
    Diabetes 55:3418-28. 2006
  10. pmc PRDM16 controls a brown fat/skeletal muscle switch
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nature 454:961-7. 2008

Research Grants

  1. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
  2. Role of the PPARb in epithelial cell proliferation
    Jeffrey Peters; Fiscal Year: 2004
  3. Role of PPARbeta in colon carcinogenesis
    Jeffrey Peters; Fiscal Year: 2007
  4. FASEB Conference: Mechanisms of Liver Growth and Disease
    Janardan Reddy; Fiscal Year: 2002
  5. Biologic Studies with Peroxisome Proliferators and PPARs
    Janardan Reddy; Fiscal Year: 2008
  6. Stratum Corneum Acidification in the Neonate
    Kenneth Feingold; Fiscal Year: 2007
  7. PPARs and LXR Regulate Epidermal Differentiation
    Kenneth Feingold; Fiscal Year: 2006
  8. Cell type gene delivery and alcoholic liver disease
    Michael Wheeler; Fiscal Year: 2006
  9. Analysis of Therapeutic Adipose Tissue Remodeling
    JAMES GRANNEMAN; Fiscal Year: 2004
  10. BETA 1 AND BETA 3 ADRENORECEPTORS
    JAMES GRANNEMAN; Fiscal Year: 2001

Detail Information

Publications167 found, 100 shown here

  1. pmc Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    S Kersten
    Institut de Biologie Animale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    J Clin Invest 103:1489-98. 1999
    ..The nuclear receptor known as peroxisome proliferator-activated receptor alpha (PPARalpha) was found to play a role in regulating mitochondrial and peroxisomal fatty acid oxidation, suggesting that ..
  2. doi The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation
    Emma Barroso
    Department of Pharmacology and Therapeutic Chemistry, and Institut de Biomedicina de la University of Barcelona, Barcelona Spain
    Endocrinology 152:1848-59. 2011
    ..Here we examined the effects of the peroxisome proliferator-activated receptors (PPAR)-β/δ activator GW501516 on high-fat diet (HFD)-induced hypertriglyceridemia and hepatic fatty acid oxidation...
  3. ncbi Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway
    Brian N Finck
    Center for Cardiovascular Research and Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 4:199-210. 2006
    ..Lipin activates mitochondrial fatty acid oxidative metabolism by inducing expression of the nuclear receptor PPARalpha, a known PGC-1alpha target, and via direct physical interactions with PPARalpha and PGC-1alpha...
  4. doi Regulatory mechanism governing the diurnal rhythm of intestinal H+/peptide cotransporter 1 (PEPT1)
    Hirofumi Saito
    Dept of Pharmacy, Kyoto Univ Hospital, Sakyo ku, Kyoto 606 8507, Japan
    Am J Physiol Gastrointest Liver Physiol 295:G395-402. 2008
    ..we also demonstrated that transcription factors, Sp1, Cdx2, and peroxisome proliferator-activated receptor-alpha (PPAR-alpha) contribute to the basal, intestine-specific, and fasting-induced expression of PEPT1, respectively...
  5. pmc Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism
    Sarah Garrido-Urbani
    Department of Pathology and Immunology, Centre Medical Universitaire, University of Geneva, Geneva, Switzerland
    PLoS ONE 6:e14665. 2011
    ..NOX1 silencing decreases endothelial cell migration and tube-like structure formation, through the inhibition of PPARα, a regulator of NF-κB...
  6. pmc A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
    T C Leone
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:7473-8. 1999
    ..that the lipid-activated transcription factor, the peroxisome proliferator-activated receptor alpha (PPARalpha), plays a pivotal role in the cellular metabolic response to fasting...
  7. pmc Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    J J Lehman
    Department of Medicine, and Department of Pathology, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 106:847-56. 2000
    ..These results identify PGC-1 as a critical regulatory molecule in the control of cardiac mitochondrial number and function in response to energy demands...
  8. pmc PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
    Ni Huiping Son
    Division of Preventive Medicine and Nutrition, Columbia University, New York, New York 10032, USA
    J Clin Invest 120:3443-54. 2010
    ..b>PPARγ expression is increased in the hearts of humans with metabolic syndrome, and use of PPARγ agonists is associated ..
  9. ncbi OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization
    Nathan E Wolins
    Department of Medicine, 660 S Euclid Ave, Campus Box 8127, St Louis, MO 63110, USA
    Diabetes 55:3418-28. 2006
    ..pharmacological (peroxisome proliferator-activated receptor [PPAR] agonists), and genetic (muscle-specific PPARalpha overexpression) perturbations that increase fatty acid utilization...
  10. pmc PRDM16 controls a brown fat/skeletal muscle switch
    Patrick Seale
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nature 454:961-7. 2008
    ..PRDM16 stimulates brown adipogenesis by binding to PPAR-gamma (peroxisome-proliferator-activated receptor-gamma) and activating its transcriptional function...
  11. ncbi MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha
    Tomohiro Yamaguchi
    Graduate School of Life Science, University of Hyogo, 3 2 1 Koto, Kamigori, Hyogo, 678 1297, Japan
    J Biol Chem 281:14232-40. 2006
    ..was found to be up-regulated at both mRNA and protein levels in the heart and liver by a selective ligand for PPARalpha, Wy14,643, but not in PPARalpha knock-out mice...
  12. doi Transcriptomic analysis of PPARalpha-dependent alterations during cardiac hypertrophy
    Pascal J H Smeets
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
    Physiol Genomics 36:15-23. 2008
    ..Although PPARalpha has been shown to mitigate cardiac hypertrophy, knowledge about underlying mechanisms and the nature of ..
  13. pmc Fenofibrate, a peroxisome proliferator-activated receptor α agonist, alters triglyceride metabolism in enterocytes of mice
    Aki Uchida
    Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
    Biochim Biophys Acta 1811:170-6. 2011
    ..These results suggest that the effects of fenofibrate on the small intestine play a critical role in the hypotriglyceridemic effects of fenofibrate...
  14. doi Protective effects of adiponectin against renal ischemia-reperfusion injury via prostacyclin-PPARα-heme oxygenase-1 signaling pathway
    Ching Feng Cheng
    Department of Medical Research, Tzu Chi General Hospital, Hualien, Taiwan
    J Cell Physiol 227:239-49. 2012
    ..analysis revealed that APN up-regulates heme oxygenase-1 (HO-1) via peroxisome-proliferator-activated-receptor-α (PPARα) dependent pathway which is mediated through the enhancement of COX-2 and 6-keto PGF1α expression...
  15. doi Cardiac hypertrophy is enhanced in PPAR alpha-/- mice in response to chronic pressure overload
    Pascal J H Smeets
    Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Cardiovasc Res 78:79-89. 2008
    Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a nuclear receptor regulating cardiac metabolism that also has anti-inflammatory properties...
  16. pmc Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARalpha target gene in cardioprotection
    Hamid el Azzouzi
    Hubrecht Institute and Interuniversity Cardiology Institute Netherlands, Royal Netherlands Academy of Sciences, 3584 CS Utrecht, The Netherlands
    J Biol Chem 286:14598-607. 2011
    ..members of the nuclear receptor family of ligand-activated transcription factors and consist of the three isoforms, PPARα, PPARβ/δ, and PPARγ...
  17. pmc Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16
    Elayne Hondares
    Department of Biochemistry and Molecular Biology and Institute of Biomedicine, University of Barcelona, and CIBER Fisiopatologia de la Obesidad y Nutricion, Barcelona, Catalonia, Spain
    J Biol Chem 286:43112-22. 2011
    Peroxisome proliferator activated receptor α (PPARα) is a distinctive marker of the brown fat phenotype that has been proposed to coordinate the transcriptional activation of genes for lipid oxidation and for thermogenic uncoupling ..
  18. pmc Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human
    Maryam Rakhshandehroo
    Nutrigenomics Consortium, Top Institute TI Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 4:e6796. 2009
    Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver...
  19. doi Liver-specific peroxisome proliferator-activated receptor alpha target gene regulation by the angiotensin type 1 receptor blocker telmisartan
    Markus Clemenz
    Center for Cardiovascular Research, Institute of Pharmacology, Charite Universitatsmedizin Berlin, Hessische Str 3 4, 10115 Berlin, Germany
    Diabetes 57:1405-13. 2008
    ..investigates the molecular mechanisms of telmisartans hypolipidemic actions, in particular its effect on the PPARalpha pathway...
  20. ncbi AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1
    Woo Je Lee
    Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea
    Biochem Biophys Res Commun 340:291-5. 2006
    ..show that AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) increases mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle, and that inhibition of PPARalpha and ..
  21. ncbi Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta
    Deborah M Muoio
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 277:26089-97. 2002
    ..In the present study we used PPAR alpha knockout (KO) mice to determine whether this transcription factor is essential for regulating fuel metabolism in ..
  22. ncbi PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
    Seung Hoi Koo
    Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
    Nat Med 10:530-4. 2004
    ..The nuclear hormone receptor coactivator PGC-1 (peroxisome proliferator-activated (PPAR)-gamma coactivator-1) has been implicated in the onset of type 2 diabetes...
  23. ncbi Genome-wide analysis of PPARalpha activation in murine small intestine
    Meike Bünger
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Physiol Genomics 30:192-204. 2007
    The peroxisome proliferator-activated receptor alpha (PPARalpha) is a fatty acid-activated transcription factor that governs a variety of biological processes. Little is known about the role of PPARalpha in the small intestine...
  24. ncbi Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro
    Ling Ding
    Institute of Pharmacology Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
    Cell Biol Int 31:1002-9. 2007
    Peroxisome proliferator-activated receptor alpha (PPARalpha) plays a key role in the transcriptional regulation of genes involved in cellular lipid and energy metabolism, which is abundantly expressed in tissues with high energy demand, ..
  25. doi Alterations in carbohydrate metabolism and its regulation in PPARalpha null mouse hearts
    Roselle Gélinas
    Montreal Heart Inst Research Center, 5350, Montreal, Quebec, Canada H1T 1C8
    Am J Physiol Heart Circ Physiol 294:H1571-80. 2008
    ..of CHOs for energy production and anaplerosis in 12-wk-old peroxisome proliferator-activating receptor-alpha (PPARalpha) null mice (a model of FA beta-oxidation defects)...
  26. doi Monocarboxylate transporter (MCT)-1 is up-regulated by PPARalpha
    Bettina König
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle, Germany
    Biochim Biophys Acta 1780:899-904. 2008
    ..In this study we observed for the first time that activation of PPARalpha in rats by clofibrate treatment or fasting increased hepatic mRNA concentration of MCT1...
  27. pmc Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors
    Hyun Bae Kim
    Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Biol 30:3126-39. 2010
    ..These observations place lipin 1 as a potentially important link between triacylglycerol synthesis and adipose tissue inflammation...
  28. doi PPARα deficiency augments a ketogenic diet-induced circadian PAI-1 expression possibly through PPARγ activation in the liver
    Katsutaka Oishi
    Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki, Japan
    Biochem Biophys Res Commun 401:313-8. 2010
    ..To determine whether peroxisome proliferator-activated receptor α (PPARα) is involved in hypofibrinolytic status induced by a KD, we examined the expression profiles of PAI-1 and ..
  29. ncbi The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver
    Rinke Stienstra
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, The Netherlands
    J Hepatol 46:869-77. 2007
    ..It is known that PPARalpha also has an anti-inflammatory effect, which is mainly achieved by down-regulating pro-inflammatory genes...
  30. ncbi Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines
    T E Akiyama
    Laboratory of Metabolism, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:39088-93. 2001
    Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in obesity...
  31. ncbi A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with hig
    Fiona M Campbell
    Department of Pharmacology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Biol Chem 277:4098-103. 2002
    Peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor transcription factor that has an important role in controlling cardiac metabolic gene expression...
  32. pmc The G0/G1 switch gene 2 is a novel PPAR target gene
    Fokko Zandbergen
    Nutrition, Metabolism and Genomics Group, Wageningen University, 6700 EV, Wageningen, The Netherlands
    Biochem J 392:313-24. 2005
    ..By comparing liver mRNAs of wild-type and PPARalpha-null mice using microarrays, a novel putative target gene of PPARalpha, G0S2 (G0/G1 switch gene 2), was ..
  33. ncbi Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock
    Laurence Canaple
    Structure and Evolution of Nuclear Receptors, Centre National de la Recherche Scientifique CNRS Unité Mixte de Recherche 5161, Institut Fédératif de Recherche IFR 128 BioSciences Lyon Gerland, Lyon, France
    Mol Endocrinol 20:1715-27. 2006
    Recent evidence has emerged that peroxisome proliferator-activated receptor alpha (PPARalpha), which is largely involved in lipid metabolism, can play an important role in connecting circadian biology and metabolism...
  34. pmc Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice
    Nicolas Leuenberger
    Center for Integrative Genomics, National Research Center Frontiers in Genetics, Switzerland
    J Clin Invest 119:3138-48. 2009
    ..Here we show that in mice, PPARalpha has broad female-dependent repressive actions on hepatic genes involved in steroid metabolism and immunity...
  35. pmc Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart
    Biao Lu
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0T6
    Biochem J 385:469-77. 2005
    ..tissue distribution, and enzyme characterization of mAGPATs (murine AGPATs) and regulation of cardiac mAGPATs by PPARalpha (peroxisome-proliferator-activated receptor alpha)...
  36. ncbi Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain
    Claude Knauf
    Unit Mixte de Recherche, 5018, Centre National de la Recherche Scientifique University Paul Sabatier, IFR 31, Bt L1 Rue J Poulhès, 31403 Toulouse, France
    Endocrinology 147:4067-78. 2006
    ..Here we compared PPARalpha knockout mice with wild type and confirmed that the former developed hypoglycemia during fasting...
  37. ncbi Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes
    Andreas Zirlik
    Dept of Cardiology and Angiology, University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Thromb Haemost 101:1060-9. 2009
    ..Fibrates are hypolipidemic peroxisome proliferator activated receptor-alpha (PPARalpha) agonists. Recent laboratory and clinical observations indicate that they are also anti-atherosclerotic...
  38. doi A pan-PPAR ligand induces hepatic fatty acid oxidation in PPARalpha-/- mice possibly through PGC-1 mediated PPARdelta coactivation
    Therese H Røst
    Institute of Medicine, University of Bergen, Norway
    Biochim Biophys Acta 1791:1076-83. 2009
    ..b>PPARalpha-/- mice were employed to study the role of PPARalpha after TTA treatment...
  39. pmc Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
    S S Lee
    Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 15:3012-22. 1995
    To gain insight into the function of peroxisome proliferator-activated receptor (PPAR) isoforms in rodents, we disrupted the ligand-binding domain of the alpha isoform of mouse PPAR (mPPAR alpha) by homologous recombination...
  40. pmc A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice
    F Djouadi
    INSERM U319, Universite Paris 7, Paris, France
    J Clin Invest 102:1083-91. 1998
    The peroxisome proliferator-activated receptor alpha (PPARalpha) is a nuclear receptor implicated in the control of cellular lipid utilization...
  41. ncbi Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors
    N Masuda
    Department of Life Science, Himeji Institute of Technology, Kamigori, Hyogo 678 1297, Japan
    Gene 221:225-33. 1998
    ..receptor (PPAR), a rat liver cDNA library was screened by a yeast two-hybrid system, using the mouse PPARalpha as a bait...
  42. ncbi Reduced hepatic fatty acid oxidation in fasting PPARalpha null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression
    C Le May
    Endocrinologie Métabolisme et Développement, UPR 1524 CNRS, Meudon, France
    FEBS Lett 475:163-6. 2000
    ..has been measured in hepatocytes isolated from 24 h starved peroxisome proliferator-activated receptor-alpha (PPARalpha) null and wild-type mice...
  43. ncbi Peroxisome proliferator-activated receptor alpha is not rate-limiting for the lipoprotein-lowering action of fish oil
    J Dallongeville
    Departement d Atherosclerose, INSERM U 508, and INSERM U 325, Institut Pasteur de Lille, 59019 Lille, France
    J Biol Chem 276:4634-9. 2001
    ..fatty acids contained in fish oil are activators of peroxisome proliferator-activated receptor alpha (PPARalpha)...
  44. pmc PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice
    K Tordjman
    Department of Medicine and the Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Clin Invest 107:1025-34. 2001
    b>PPARalpha is a ligand-dependent transcription factor expressed at high levels in the liver...
  45. ncbi Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent
    Dallas C Jones
    Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA
    J Biol Chem 277:6838-45. 2002
    ..b>PPARalpha and PPARgamma ligands have been demonstrated to exert anti-inflammatory activities in macrophages by repressing ..
  46. ncbi Hepatic expression of PPARalpha, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner
    E Shyong Tai
    Department of Endocrinology, Singapore General Hospital, Outram Road, Singapore 169608
    FEBS Lett 546:237-40. 2003
    ..Here we show that hepatic expression of Peroxisome proliferator-activated receptor alpha (PPARalpha), a nuclear receptor that regulates lipid metabolism and inflammation, is regulated in a gender-specific manner ..
  47. ncbi Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment
    Dominique Deplanque
    Laboratoire de Pharmacologie, Universite de Lille 2, Faculté deMédecine, Lille, 59045 France
    J Neurosci 23:6264-71. 2003
    ..Here, we show that a peroxisome proliferator-activated receptor (PPAR-alpha) activator, fenofibrate, protects against cerebral injury by anti-oxidant and anti-inflammatory mechanisms...
  48. ncbi Hepatic de novo synthesis of glucose 6-phosphate is not affected in peroxisome proliferator-activated receptor alpha-deficient mice but is preferentially directed toward hepatic glycogen stores after a short term fast
    Robert H J Bandsma
    Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Hospital Groningen, 9713 G2 Groningen, The Netherlands
    J Biol Chem 279:8930-7. 2004
    Apart from impaired beta-oxidation, Pparalpha-deficient (Pparalpha(-/-)) mice suffer from hypoglycemia during prolonged fasting, suggesting alterations in hepatic glucose metabolism...
  49. ncbi Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor alpha
    Connie Cheung
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cancer Res 64:3849-54. 2004
    ..fibrate drugs function as agonists for the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha). Sustained activation of PPARalpha leads to the development of liver tumors in rats and mice...
  50. ncbi L-FABP is exclusively expressed in alveolar macrophages within the myeloid lineage: evidence for a PPARalpha-independent expression
    Christian Schachtrup
    Department of Biochemistry, University of Munster, Munster, Germany
    Int J Biochem Cell Biol 36:2042-53. 2004
    ..A low level PPARalpha mRNA could be detected in peritoneal macrophages and immature dendritic cells but not in mature dendritic cells ..
  51. pmc PPARalpha governs glycerol metabolism
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    J Clin Invest 114:94-103. 2004
    ..glycerol transporters aquaporin 3 and 9, are upregulated by fasting in wild-type mice but not in mice lacking PPARalpha. Furthermore, expression of these genes was induced by the PPARalpha agonist Wy14643 in wild-type but not ..
  52. ncbi A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes
    Brian N Finck
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 1:133-44. 2005
    The role of the peroxisome proliferator-activated receptor-alpha (PPARalpha) in the development of insulin-resistant diabetes was evaluated using gain- and loss-of-function approaches...
  53. ncbi Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression
    David Patsouris
    Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, P O Box 8129, 6700 EV, Wageningen, The Netherlands
    Endocrinology 147:1508-16. 2006
    ..The PPARalpha isotype is abundant in liver and activated by fasting...
  54. ncbi Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin
    David J Durgan
    USDA ARS Children s Nutrition Research Center, Baylor College of Medicine, Department of Pediatrics, 1100 Bates Street, Houston, TX 77030, USA
    Am J Physiol Heart Circ Physiol 290:H2480-97. 2006
    ..for these transcriptional changes uncovered roles for peroxisome proliferator-activated receptor-alpha (PPARalpha) and insulin as regulators of specific acsl isoforms and cte1 in the heart. Culturing ARCs with oleate (0.1-0...
  55. ncbi Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes
    Kayo Kuroyanagi
    Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611 0011, Japan
    Biochem Biophys Res Commun 366:219-25. 2008
    ..ligand assay system, we showed that citrus auraptene activates peroxisome proliferator-activated receptor (PPAR)-alpha and PPARgamma...
  56. ncbi Regulation of adiponectin receptor 2 expression via PPAR-alpha in NIT-1 cells
    Tae Woo Jung
    Samsung Biomedical Institute, Seoul, Korea
    Endocr J 56:377-82. 2009
    ..Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-alpha; this delay was abolished by ..
  57. ncbi Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
    I Issemann
    Imperial Chemical Industries PLC, Central Toxicology Laboratory, Alderley Park, Macclesfield, UK
    Nature 347:645-50. 1990
    ..Identification of a peroxisome proliferator-activated receptor should help elucidate the mechanism of the hypolipidaemic effect of these hepatocarcinogens and aid evaluation of their potential carcinogenic risk to man...
  58. pmc Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
    S A Kliewer
    Salk Institute for Biological Studies, La Jolla, CA
    Proc Natl Acad Sci U S A 91:7355-9. 1994
    ..of peroxisome proliferator-activated receptor (PPAR) isoforms in mammals, we have cloned and characterized two PPAR alpha-related cDNAs (designated PPAR gamma and -delta, respectively) from mouse...
  59. pmc A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program
    M N Sack
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:6438-43. 1997
    ..These results identify a transcriptional regulatory mechanism involved in the reinduction of a fetal metabolic program during pressure overload-induced cardiac hypertrophy...
  60. ncbi Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)
    T Aoyama
    Department of Biochemistry, Shinshu University School of Medicine, Matsumoto, Nagano 390, Japan
    J Biol Chem 273:5678-84. 1998
    Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the steroid/nuclear receptor superfamily and mediates the biological and toxicological effects of peroxisome proliferators...
  61. ncbi Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    P Costet
    Laboratoire de Pharmacologie et Toxicologie, INRA, BP 3, 31931 Toulouse, Cedex 09 France
    J Biol Chem 273:29577-85. 1998
    The alpha-isoform of the peroxisome proliferator-activated receptor (PPARalpha) is a nuclear transcription factor activated by structurally diverse chemicals referred to as peroxisome proliferators...
  62. ncbi Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging
    M E Poynter
    Department of Pathology, University of Utah, Salt Lake City, Utah 84132, USA
    J Biol Chem 273:32833-41. 1998
    ..aged mice of agents capable of activating the alpha isoform of the peroxisome proliferator-activated receptor (PPARalpha) was found to restore the cellular redox balance, evidenced by a lowering of tissue lipid peroxidation, an ..
  63. ncbi Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype
    T Hashimoto
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Biol Chem 274:19228-36. 1999
    ..Synthetic peroxisome proliferators interact with peroxisome proliferator activated receptor alpha (PPARalpha) to transcriptionally activate genes that participate in peroxisomal, microsomal, ..
  64. ncbi Central role of PPARalpha in the mechanism of action of hepatocarcinogenic peroxisome proliferators
    J C Corton
    Chemical Industry Institute of Toxicology CIIT, P O Box 12137, 6 Davis Drive, Research Triangle Park, NC 27709 2137, USA
    Mutat Res 448:139-51. 2000
    ..In this review, we discuss the evidence that PPARalpha, the predominant PPAR in the, liver is involved in the growth promoting and hepatocarcinogenic effects of PP.
  65. ncbi Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity
    K Watanabe
    Department of Clinical Pharmacology, Niigata College of Pharmacy, Niigata, Niigata 950 2081, Japan
    J Biol Chem 275:22293-9. 2000
    The peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the nuclear receptor superfamily and mediates the biological effects of peroxisome proliferators...
  66. ncbi Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
    T Hashimoto
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Biol Chem 275:28918-28. 2000
    ..enzymes in the liver are transcriptionally regulated by peroxisome proliferator-activated receptor alpha (PPARalpha), we investigated the role of PPARalpha in the induction of these enzymes in response to fasting and their ..
  67. ncbi Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo
    L G Kömüves
    Departments of Dermatology, Medicine, and Pediatrics, University of California, San Francisco School of Medicine, San Francisco, California, USA
    J Invest Dermatol 115:353-60. 2000
    Our recent studies have demonstrated that PPARalpha activators stimulate differentiation and inhibit proliferation in cultured human keratinocytes and accelerate epidermal development and permeability barrier formation in fetal rat skin ..
  68. ncbi Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure
    C Chen
    Toxicology Program, Department of Pharmaceutical Sciences and Department of Pathobiology, University of Connecticut, Storrs, Connecticut 06269 2092, USA
    Toxicol Sci 57:338-44. 2000
    The purpose of this study was to investigate whether activation of the nuclear receptor PPARalpha is needed for protection from acetaminophen (APAP) hepatotoxicity produced by repeated administration of the peroxisome proliferator ..
  69. ncbi PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance
    M Guerre-Millo
    Unit 465, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France
    Diabetes 50:2809-14. 2001
    Peroxisome proliferator-activated receptor (PPAR)-alpha controls the expression of genes involved in lipid metabolism...
  70. ncbi Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models
    Mary Y Sheu
    Department of Medicine, University of California San Francisco School of Medicine, San Francisco, California, USA
    J Invest Dermatol 118:94-101. 2002
    ....
  71. pmc Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin
    Mary C Sugden
    Department of Diabetes and Metabolic Medicine, Division of General and Developmental Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
    Biochem J 364:361-8. 2002
    The aim of the present study was to determine whether peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency disrupts the normal regulation of triacylglycerol (TAG) accumulation, hepatic lipogenesis and glycogenesis by ..
  72. ncbi The functional efficiency of lipogenic and cholesterogenic gene expression in normal mice and in mice lacking the peroxisomal proliferator-activated receptor-alpha (PPAR-alpha)
    Geoffrey F Gibbons
    Metabolic Research Laboratory, University of Oxford, Radcliffe Infirmary, Woodstock Road, UK
    Adv Enzyme Regul 42:227-47. 2002
  73. ncbi Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production
    Jun Xu
    Department of Medicine, the Laboratory of Metabolomics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Biol Chem 277:50237-44. 2002
    The hypoglycemia seen in the fasting PPARalpha null mouse is thought to be due to impaired liver fatty acid beta-oxidation. The etiology of hypoglycemia in the PPARalpha null mouse was determined via stable isotope studies...
  74. pmc PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue
    Y Lee
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 99:11848-53. 2002
    ..PPAR)alpha expression, which was increased during the rapid loss of fat, we infused adenovirus-leptin into PPAR alpha(-/-) and PPAR alpha(+/+) mice...
  75. ncbi Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme
    Olivier Barbier
    Unité de Recherche 545, Institut National de la Sante et de la Recherche Medicale, Departement d Atherosclerose, Institut Pasteur de Lille and the Faculté de Pharmacie, Universite de Lille II, 59019 Lille, France
    J Biol Chem 278:32852-60. 2003
    ..identify UGT2B4 as a novel target gene of the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR alpha), which mediates the hypolipidemic action of fibrates...
  76. ncbi Peroxisome proliferator-activated receptor alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation
    Dallas C Jones
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    J Immunol 171:196-203. 2003
    Expression of the nuclear hormone receptor peroxisome proliferator-activated receptor alpha (PPARalpha) in resting lymphocytes was recently established, although the physiologic role(s) played by this nuclear hormone receptor in these ..
  77. ncbi Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice
    Emilia Ip
    Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Westmead, Australia
    Hepatology 38:123-32. 2003
    ..the hypothesis that increasing Cyp4a through activation of peroxisome proliferator-activated receptor alpha (PPARalpha) should aggravate steatohepatitis produced by feeding a methionine and choline deficient (MCD) diet...
  78. ncbi Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice
    Carlos Bernal-Mizrachi
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110 USA
    Nat Med 9:1069-75. 2003
    ..PPAR-alpha) mediates these sequelae, mice deficient in low-density lipoprotein receptor (Ldlr-/-), with (Ppara+/+) or without (Ppara-/-) PPAR-alpha, were treated chronically with dexamethasone...
  79. ncbi Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice
    Brian L Knight
    Lipoprotein Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Hospital, London W12 ONN, UK
    J Lipid Res 44:2049-58. 2003
    Dietary supplementation with the peroxisome proliferator-activated receptor alpha (PPAR alpha) ligand WY 14,643 gave rise to a 4- to 5-fold increase in the expression of mRNA for the ATP binding cassette transporter A1 (ABCA1) in the ..
  80. pmc Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation
    Gaetane Woerly
    Institut National de la Sante et de la Recherche Medicale INSERM, U547 IFR17, Institut Pasteur de Lille, France
    J Exp Med 198:411-21. 2003
    ..We demonstrate here that peroxisome proliferator-activated receptors (PPARs), PPAR-alpha and PPAR-gamma, which have been shown recently to be involved in the regulation of various cell types within ..
  81. ncbi Peroxisome proliferator-activated receptor-alpha deficiency does not alter insulin sensitivity in mice maintained on regular or high-fat diet: hyperinsulinemic-euglycemic clamp studies
    Martin Haluzik
    Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
    Endocrinology 145:1662-7. 2004
    Chronic peroxisome proliferator-activated receptor (PPAR)-alpha activation improves glucose metabolism in rodent models of insulin resistance and diabetes; however, PPAR-alpha deficiency was also reported to protect against high-fat diet (..
  82. ncbi Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha)
    Manuel Guzman
    Department of Pharmacology, University of California, Irvine, CA 92697 4260, USA
    J Biol Chem 279:27849-54. 2004
    ..FAE oleoylethanolamide (OEA) reduces feeding and body weight gain by activating the nuclear receptor PPAR-alpha (peroxisome proliferator-activated receptor alpha)...
  83. ncbi Requirement of PPARalpha in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation
    Susanna S T Lee
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China
    J Lipid Res 45:2025-37. 2004
    The peroxisome proliferator-activated receptor alpha (PPARalpha) has been implicated as a key control of fatty acid catabolism during the cellular fasting...
  84. ncbi Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver
    Steven P Anderson
    Investigative Toxicology and Pathology Group, Safety Assessment, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA
    Mol Pharmacol 66:1440-52. 2004
    ..is controlled in part by the nuclear receptors peroxisome proliferator (PP)-activated receptor alpha (PPARalpha) and liver X receptor (LXR) through regulation of genes involved in fatty acid and cholesterol metabolism...
  85. ncbi The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes
    Steven P Anderson
    Investigative Toxicology and Pathology Group, Safety Assessment, GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 279:52390-8. 2004
    The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), in addition to regulating lipid homeostasis, controls the level of tissue damage after chemical or physical stress...
  86. ncbi Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis
    Thomas Hays
    Department of Veterinary Science and Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA
    Carcinogenesis 26:219-27. 2005
    ..Peroxisome proliferator-activated receptor-alpha (PPARalpha) is required to mediate alterations in PPARalpha target gene expression, repress apoptosis, enhance replicative ..
  87. ncbi Role of endogenous and exogenous ligands for the peroxisome proliferators activated receptors alpha (PPAR-alpha) in the development of inflammatory bowel disease in mice
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Policlinico Universitario, Messina, Italy
    Lab Invest 84:1643-54. 2004
    The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) is a member of the nuclear receptor superfamily of ligand-dependent transcription factors related to retinoid, steroid and thyroid hormone receptors...
  88. ncbi Activation of peroxisome proliferator-activated receptor alpha increases the expression and activity of microsomal triglyceride transfer protein in the liver
    Caroline Améen
    Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital, S 41345 Goteborg, Sweden
    J Biol Chem 280:1224-9. 2005
    ..In this study, we sought to determine whether PPARalpha activation increases MTP expression and activity...
  89. pmc A role for PPARalpha in the control of SREBP activity and lipid synthesis in the liver
    Brian L Knight
    MRC Clinical Sciences Centre, Faculty of Medicine Imperial College, Hammersmith Hospital, London W12 ONN, UK
    Biochem J 389:413-21. 2005
    Inclusion of the PPARalpha (peroxisome-proliferator-activated receptor alpha) activator WY 14,643 in the diet of normal mice stimulated the hepatic expression of not only genes of the fatty acid oxidation pathway, but also those of the ..
  90. ncbi Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation
    Andreas Jakobsson
    The Wenner Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE 10691 Stockholm, Sweden
    Am J Physiol Endocrinol Metab 289:E517-26. 2005
    ..the cold-induced Elovl3 expression is under the control of peroxisome proliferator-activated receptor-alpha (PPARalpha) and that this regulation is part of a fundamental divergence in the regulation of expression for the different ..
  91. ncbi Suppression of expression of muscle-associated proteins by PPARalpha in brown adipose tissue
    Yuhong Tong
    Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto, Nagano 390 8621, Japan
    Biochem Biophys Res Commun 336:76-83. 2005
    Peroxisome proliferator-activated receptor alpha (PPARalpha) belongs to the steroid/nuclear receptor superfamily...
  92. ncbi Decreased contractile and metabolic reserve in peroxisome proliferator-activated receptor-alpha-null hearts can be rescued by increasing glucose transport and utilization
    Ivan Luptak
    NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Circulation 112:2339-46. 2005
    Downregulation of peroxisome proliferator-activated receptor-alpha (PPARalpha) in hypertrophied and failing hearts leads to the reappearance of the fetal metabolic pattern, ie, decreased fatty acid oxidation and increased reliance on ..
  93. pmc Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis
    Philippe Lefebvre
    Departement d Atherosclerose, Institut Pasteur de Lille, INSERM U545, and Université de Lille 2, Lille, France
    J Clin Invest 116:571-80. 2006
    b>PPARalpha is a nuclear receptor that regulates liver and skeletal muscle lipid metabolism as well as glucose homeostasis...
  94. ncbi Accelerated diabetic nephropathy in mice lacking the peroxisome proliferator-activated receptor alpha
    Cheol Whee Park
    Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, 62, Yoido Dong, Youngdeungpo ku, Seoul, Korea 150 713
    Diabetes 55:885-93. 2006
    ..The present studies were aimed at determining the role of PPARalpha in the pathogenesis of diabetic nephropathy using PPARalpha-knockout mice and cultured murine mesangial cells...
  95. ncbi A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome
    Helen J Atherton
    Department of Biochemistry, University of Cambridge, Cambridge, UK
    Physiol Genomics 27:178-86. 2006
    ..beta-oxidation in the liver, in part under the regulation of peroxisome proliferator-activated receptor-alpha (PPAR-alpha)...
  96. ncbi n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner
    Susanne Neschen
    Yale University School of Medicine, Howard Hughes Medical Institute, Departments of Internal Medicine, The Anlyan Center, P O Box 9812, New Haven, CT 06536 8012, USA
    Diabetes 56:1034-41. 2007
    ..oil, protect against high-fat diet-induced insulin resistance through peroxisome proliferator-activated receptor (PPAR)-alpha activation and a subsequent decrease in intracellular lipid abundance...
  97. ncbi Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation
    Rinke Stienstra
    Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands
    Endocrinology 148:2753-63. 2007
    ..The transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) has been shown to have a strong antiinflammatory action in liver...
  98. ncbi Role of oxidative stress in cardiac dysfunction of PPARalpha-/- mice
    Aziz Guellich
    INSERM U689, Centre de Recherche Cardiovasculaire Inserm Lariboisiere, 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, France
    Am J Physiol Heart Circ Physiol 293:H93-H102. 2007
    This study was designed to determine the effects of PPARalpha lack on cardiac mechanical performance and to identify potential intracellular mechanisms linking PPARalpha pathway deficiency to cardiac contractile dysfunction...
  99. pmc Genetic manipulations of PPARs: effects on obesity and metabolic disease
    Yaacov Barak
    The Jackson Laboratory, ME, USA
    PPAR Res 2007:12781. 2007
    ..Considering the effects of PPAR ligands on critical aspects of systemic physiology, including obesity, lipid metabolism, insulin resistance, and ..
  100. pmc The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha
    Qian Yang
    Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Toxicol Sci 101:132-9. 2008
    ..response to peroxisome proliferators (PPs) mediated by peroxisome proliferator-activated receptor (PPAR)alpha, PPAR alpha-humanized transgenic mice were generated using a P1 phage artificial chromosome (PAC) genomic clone bred onto a ..
  101. pmc Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart
    Eileen M Burkart
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 117:3930-9. 2007
    In the diabetic heart, chronic activation of the PPARalpha pathway drives excessive fatty acid (FA) oxidation, lipid accumulation, reduced glucose utilization, and cardiomyopathy...

Research Grants20

  1. Modulation of AhR-dependent signaling by PPARb/d
    Jeffrey M Peters; Fiscal Year: 2010
    ..We have discovered that peroxisome proliferator-activated receptor- (PPAR-also referred to as PPAR) may also alter AhR-dependent signaling by modulating cytochrome P450 (CYP) expression...
  2. Role of the PPARb in epithelial cell proliferation
    Jeffrey Peters; Fiscal Year: 2004
    ..Despite numerous roles elucidated for the PPARa and PPARy that contribute to diseases including hyperlipidemias, atherosclerosis, obesity, diabetes and cancer, ..
  3. Role of PPARbeta in colon carcinogenesis
    Jeffrey Peters; Fiscal Year: 2007
    ..identified as a member of the peroxisome proliferator-activated receptors (PPARs) in 1994, specific roles for the PPAR-beta (also referred to as PPAR-delta) have remained elusive, Recent data suggests that the PPAR-beta may be ..
  4. FASEB Conference: Mechanisms of Liver Growth and Disease
    Janardan Reddy; Fiscal Year: 2002
    ..abstract_text> ..
  5. Biologic Studies with Peroxisome Proliferators and PPARs
    Janardan Reddy; Fiscal Year: 2008
    ..biochemical and metabolic perturbations occurring in liver as a result of activation of PPARs, in particular PPARalpha and PPARgamma, are responsible for alterations in hepatocellular function and their proliferative potential...
  6. Stratum Corneum Acidification in the Neonate
    Kenneth Feingold; Fiscal Year: 2007
    ..these pathways develop, and the SC ultimately acidifies, a process that can be accelerated by activation of PPAR alpha, PPAR delta, and LXR...
  7. PPARs and LXR Regulate Epidermal Differentiation
    Kenneth Feingold; Fiscal Year: 2006
    ..unreadable] [unreadable] It is our hypothesis that NHR liposensors (PPAR-alpha, -beta/ delta, -gamma, and LXR) regulate keratinocyte differentiation by first sensing lipid levels, and then ..
  8. Cell type gene delivery and alcoholic liver disease
    Michael Wheeler; Fiscal Year: 2006
    ..In addition, through didactic training, and interactions with his mentor and key faculty, the applicant will acquire new skills that will allow him to become a successful member of the alcohol research community. ..
  9. Analysis of Therapeutic Adipose Tissue Remodeling
    JAMES GRANNEMAN; Fiscal Year: 2004
    ..2) To examine adipose tissue cellular dynamics during therapeutic remodeling induced by agonist activation of beta3-adrenergic receptors and PPAR-gamma.
  10. BETA 1 AND BETA 3 ADRENORECEPTORS
    JAMES GRANNEMAN; Fiscal Year: 2001
    ..Aim 2. To further characterize the differential signaling properties of beta1- beta3-AR and to examine the cellular and molecular basis. Specific Aim 3. To examine the molecular pharmacology of beta3-AR-selective agonists. ..
  11. Role of BMPs on Brown Adipogenesis and Thermogenesis
    Yu Hua Tseng; Fiscal Year: 2006
    ..abstract_text> ..
  12. Ketone Dysregulation and Muscle Insulin Resistance
    DEBORAH MUOIO; Fiscal Year: 2006
    ..abstract_text> ..
  13. Involvement of Myeloperoxidase in Atherosclerosis
    Wanda Reynolds; Fiscal Year: 2006
    ..These studies will reveal if MPO-generated oxidants promote atherosclerosis in mouse models, thereby humanizing existing mouse models, and enabling investigations of the role of MPO-mediated oxidation in atherosclerosis. ..
  14. Transcriptional Coactivators in Liver Function
    Janardan Reddy; Fiscal Year: 2007
    Members of the peroxisome proliferator-activated receptor subfamily (PPARalpha, PPARgamma, and PPARdelta) play a central role in lipid metabolism/energy homeostasis, adipocyte differentiation, and cancer...
  15. ROLE OF INSULIN AND IGF-1 ON BROWN ADIPOCYTES
    Yu Hua Tseng; Fiscal Year: 2003
    ..Accomplishment of the proposed studies will further our understanding on hormonal controls of metabolism and survival of brown adipocytes. ..
  16. Effects of Psychological Stress on the Stratum Corneum
    Kenneth Feingold; Fiscal Year: 2008
    ..Aim 4: To determine if the abnormalities in permeability barrier homeostasis and SC integrity/ cohesion induced by GC treatment in humans, are due to the inhibition of epidermal lipid synthesis. ..
  17. IDENTIFICATION OF LIVER STEM CELLS IN PANCREAS
    Janardan Reddy; Fiscal Year: 2002
    ....
  18. Transcriptional Coactivators in Liver Function
    Janardan Reddy; Fiscal Year: 2008
    ..liver carcinogenesis; 2) investigate the functional roles of coactivators PBP, PRIP and PIMT in nuclear receptor PPAR and PPAR signaling mechanisms necessary for hepatic energy metabolism (fatty acid oxidation), 3) determine the role ..
  19. Mechanisms linking the adipogenic phenotype of aging muscle to insulin resistance
    Deborah M Muoio; Fiscal Year: 2010
    ....