Postn

Summary

Gene Symbol: Postn
Description: periostin, osteoblast specific factor
Alias: A630052E07Rik, AI747096, OSF-2, Osf2, PLF, periostin, osteoblast specific factor 2 (fasciclin I-like), osteoblast-specific factor 2, periostin-like factor
Species: mouse

Top Publications

  1. pmc Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development
    Vesna Todorovic
    Department of Cell Biology, NYU Langone Medical Center, New York, New York 10016, USA
    Dev Dyn 240:176-87. 2011
  2. pmc Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents
    Daihiko Hakuno
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 120:2292-306. 2010
  3. pmc Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart
    Paige Snider
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA
    Circ Res 102:752-60. 2008
  4. pmc Periostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon
    Yoshinao Kikuchi
    Department of Pathology and Diagnostic Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Histochem Cytochem 56:753-64. 2008
  5. doi Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells
    Daniel L Coutu
    Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    J Biol Chem 283:17991-8001. 2008
  6. pmc An absence of Twist1 results in aberrant cardiac neural crest morphogenesis
    Joshua W Vincentz
    Riley Heart Research Center, Riley Hospital for Children, Department of Pediatrics Pediatric Cardiology, Indiana Medical School, 1044 W Walnut St, Indianapolis, IN 46202 5225, USA
    Dev Biol 320:131-9. 2008
  7. pmc Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses
    C Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Mucosal Immunol 1:289-96. 2008
  8. doi Mechanical loading promotes Lewis lung cancer cell growth through periostin
    Dedong Ma
    Department Respiratory Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, China
    In Vitro Cell Dev Biol Anim 45:467-72. 2009
  9. pmc Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway
    Guohong Li
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, United States
    Atherosclerosis 208:358-65. 2010
  10. pmc The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
    J Biol Chem 284:35939-50. 2009

Research Grants

Patents

  1. NOVEL PROTEIN HAVING OSTEOGENIC ACTION AND ITS PRODUCTION

Scientific Experts

  • Nicolas Bonnet
  • Shawn K Ahlfeld
  • Isao Kii
  • Ryuichi Morishita
  • ARNO WESSELS
  • Vinciane Gaussin
  • Judith Litvin
  • Nagako Yoshiba
  • Guohong Li
  • Paige Snider
  • Elizabeth M Snyder
  • Vesna Todorovic
  • Fiona M Watt
  • Simon J Conway
  • Akira Kudo
  • Masashi Shimazaki
  • Kazuhiko Arima
  • Norio Amizuka
  • Angela Lorts
  • Takashi Nishiyama
  • Kenji Izuhara
  • Shoichi Suzuki
  • Miho Masuoka
  • Shoichiro Ohta
  • Shuji Toda
  • Hiroshi Shiraishi
  • Roger R Markwald
  • Minqi Li
  • Dedong Ma
  • Jian Wang
  • Andrew Lindsley
  • Rhonda Rogers
  • Russell A Norris
  • Kazuto Taniguchi
  • Mariko Kyutoku
  • Ralston M Barnes
  • Agnieszka Kruzynska-Frejtag
  • Jeffery D Molkentin
  • Joshua W Vincentz
  • Masashi Fukayama
  • Yoshinao Kikuchi
  • Anthony B Firulli
  • Hong Ming Zhou
  • Johnathan K Smid
  • Anne Cécile Huby
  • Stanley Hoffman
  • Ken ichi Yamamoto
  • Olga Simmons
  • Kanako Ontsuka
  • Shengyu Lv
  • Paritosh Prashar
  • Tomoka Hasegawa
  • J Kelley Bentley
  • Hiromi Hongo
  • Tara A Burns
  • Chihiro Tabata
  • Xiaoqiang Cai
  • Luciana K Rosselli-Murai
  • Asha Acharya
  • Munehisa Shimamura
  • E D Gordon
  • Hector F Rios
  • Bancha Satirapoj
  • Lingli Yang
  • Masaru Uchida
  • Jonathan D Cheek
  • Carsten Rudat
  • Mitsuru Arima
  • Paul Delgado-Olguín
  • Michelle D Tallquist
  • Caroline Y Sung
  • Naruto Katsuragi
  • Seung Tae Baek
  • Yoshiaki Taniyama
  • Nobutaka Koibuchi
  • Christine E Seidman
  • Basile T Siewe
  • Kontheari Sen
  • Katrina Sorocos
  • Sarita Sehra
  • Christopher L Smith
  • Wim T J Aanhaanen
  • Nathan D Hahurij
  • Hironobu Fujiwara
  • Yukiko Kitase
  • Jennifer A Schwanekamp
  • Corey H Mjaatvedt
  • Andreas Kispert
  • Pablo Villavicencio-Lorini
  • Takumi Maruhashi

Detail Information

Publications94

  1. pmc Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development
    Vesna Todorovic
    Department of Cell Biology, NYU Langone Medical Center, New York, New York 10016, USA
    Dev Dyn 240:176-87. 2011
    ..We demonstrate that Ltbp1L is a major regulator of Tgf-β activity during valvulogenesis since its absence results in a perturbed Tgf-β pathway that causes all Ltbp1L(-/-) valvular defects...
  2. pmc Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents
    Daihiko Hakuno
    Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 120:2292-306. 2010
    ..We investigated the pathophysiologic role and molecular mechanism of periostin, a protein that plays critical roles in cardiac valve development, in degenerative VHD...
  3. pmc Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart
    Paige Snider
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, USA
    Circ Res 102:752-60. 2008
    The secreted periostin protein, which marks mesenchymal cells in endocardial cushions following epithelial-mesenchymal transformation and in mature valves following remodeling, is a putative valvulogenesis target molecule...
  4. pmc Periostin is expressed in pericryptal fibroblasts and cancer-associated fibroblasts in the colon
    Yoshinao Kikuchi
    Department of Pathology and Diagnostic Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Histochem Cytochem 56:753-64. 2008
    b>Periostin is a unique extracellular matrix protein, deposition of which is enhanced by mechanical stress and the tissue repair process. Its significance in normal and neoplastic colon has not been fully clarified yet...
  5. doi Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells
    Daniel L Coutu
    Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    J Biol Chem 283:17991-8001. 2008
    ..The most abundant Gla-containing protein secreted by MSCs was identified as periostin, a previously unrecognized gamma-carboxylated protein...
  6. pmc An absence of Twist1 results in aberrant cardiac neural crest morphogenesis
    Joshua W Vincentz
    Riley Heart Research Center, Riley Hospital for Children, Department of Pediatrics Pediatric Cardiology, Indiana Medical School, 1044 W Walnut St, Indianapolis, IN 46202 5225, USA
    Dev Biol 320:131-9. 2008
    ..mesenchyme expresses the related bHLH factors Hand1 and Hand2, but reduced levels of the normal cushion marker Periostin. Lineage mapping confirms that nodule cells are exclusively of cardiac neural crest origin (cNCC), and are not ..
  7. pmc Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses
    C Blanchard
    Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Mucosal Immunol 1:289-96. 2008
    b>Periostin is an extracellular matrix protein that has been primarily studied in the context of the heart, where it has been shown to promote cardiac repair and remodeling...
  8. doi Mechanical loading promotes Lewis lung cancer cell growth through periostin
    Dedong Ma
    Department Respiratory Medicine, Qilu Hospital, Shandong University, Jinan, Shandong, China
    In Vitro Cell Dev Biol Anim 45:467-72. 2009
    Mechanical loading is known to trigger proliferation of tumor cells. Periostin is a new molecule found to increase in many cancers...
  9. pmc Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway
    Guohong Li
    Department of Neurosurgery, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, United States
    Atherosclerosis 208:358-65. 2010
    ..Previous studies have shown that periostin (PN), a novel ECM protein, is upregulated in rat carotid artery after balloon injury, and growth factor-..
  10. pmc The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, 1211 Geneva 14, Switzerland
    J Biol Chem 284:35939-50. 2009
    b>Periostin (gene Postn) is a secreted extracellular matrix protein involved in cell recruitment and adhesion and plays an important role in odontogenesis...
  11. pmc Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture
    Isao Kii
    Department of Biological Information, Tokyo Institute of Technology, 4259 Midori ku, Nagatsuta, Yokohama 226 8501
    J Biol Chem 285:2028-39. 2010
    ..Here we show that periostin, a matricellular protein, promotes incorporation of tenascin-C into the ECM and organizes a meshwork ..
  12. pmc Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal
    Pavle Vrljicak
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada V5Z 1L3
    Physiol Genomics 40:150-7. 2010
    ..These results identify molecular signatures that distinguish different phases of early heart valve formation allowing gene expression and function to be further investigated...
  13. pmc Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I
    S Takeshita
    Hoechst Japan Limited, Pharma Research Laboratories, Saitama
    Biochem J 294:271-8. 1993
    ..On the basis of the amino acid sequence homology with fasciclin I, we suggest that OSF-2 functions as a homophilic adhesion molecule in bone formation...
  14. pmc Periostin associates with Notch1 precursor to maintain Notch1 expression under a stress condition in mouse cells
    Hideyuki Tanabe
    Department of Biological Information, Tokyo Institute of Technology, Yokohama, Japan
    PLoS ONE 5:e12234. 2010
    Matricellular proteins, including periostin, modulate cell-matrix interactions and cell functions by acting outside of cells.
  15. pmc Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation
    Sarita Sehra
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 186:4959-66. 2011
    b>Periostin is a 90-kDa member of the fasciclin-containing family and functions as part of the extracellular matrix...
  16. pmc Delayed re-epithelialization in periostin-deficient mice during cutaneous wound healing
    Takashi Nishiyama
    Department of Biological Information, Tokyo Institute of Technology, Yokohama, Japan
    PLoS ONE 6:e18410. 2011
    Matricellular proteins, including periostin, are important for tissue regeneration.
  17. pmc A protective role for periostin and TGF-β in IgE-mediated allergy and airway hyperresponsiveness
    E D Gordon
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, CA, USA
    Clin Exp Allergy 42:144-55. 2012
    ..b>Periostin is a matricellular protein with roles in tissue repair following injury in both the skin and heart...
  18. pmc Periostin: novel tissue and urinary biomarker of progressive renal injury induces a coordinated mesenchymal phenotype in tubular cells
    Bancha Satirapoj
    Los Angeles Biomedical Research Institute, Harbor UCLA, Torrance, CA, USA
    Nephrol Dial Transplant 27:2702-11. 2012
    b>Periostin acts as an adhesion molecule during bone formation. Knowledge of its expression in kidney injury is scant.
  19. doi Wt1 and epicardial fate mapping
    Carsten Rudat
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circ Res 111:165-9. 2012
    ..Genetic lineage tracing systems based on Wt1 regulatory sequences provided evidence that epicardium-derived cells also adopt a myocardial fate in the mouse...
  20. pmc Deletion of periostin reduces muscular dystrophy and fibrosis in mice by modulating the transforming growth factor-β pathway
    Angela Lorts
    Department of Pediatrics, Cincinnati Children s Hospital, University of Cincinnati, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 109:10978-83. 2012
    ..matrix composition through increased secretion of profibrotic proteins, such as the matricellular protein periostin. Here we show that up-regulation and secretion of periostin is pathological and enhances disease in the δ-..
  21. pmc Periostin facilitates skin sclerosis via PI3K/Akt dependent mechanism in a mouse model of scleroderma
    Lingli Yang
    Department of Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan
    PLoS ONE 7:e41994. 2012
    b>Periostin, a novel matricellular protein, is recently reported to play a crucial role in tissue remodeling and is highly expressed under fibrotic conditions. This study was undertaken to assess the role of periostin in scleroderma.
  22. pmc Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin
    Nicolas Bonnet
    Division of Bone Diseases, Department of Rehabilitation and Geriatrics, World Health Organization Collaborating Center for Osteoporosis Prevention, Geneva University Hospital and Faculty of Medicine, Geneva 14, Switzerland
    Proc Natl Acad Sci U S A 109:15048-53. 2012
    b>Periostin (Postn) is a matricellular protein preferentially expressed by osteocytes and periosteal osteoblasts in response to mechanical stimulation and parathyroid hormone (PTH)...
  23. ncbi Involvement of periostin in regression of hyaloidvascular system during ocular development
    Mitsuru Arima
    Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 53:6495-503. 2012
    ..Although macrophages have a critical role in this process, the exact mechanism remains undetermined. Periostin is a matricellular protein involved in tissue and vascular remodeling...
  24. ncbi Periostin is an extracellular matrix protein required for eruption of incisors in mice
    Isao Kii
    Department of Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Biochem Biophys Res Commun 342:766-72. 2006
    ..Here, we show that periostin is essential for formation of the shear zone. Periostin-/- mice showed an eruption disturbance of incisors...
  25. ncbi Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels
    Erika A Bosman
    Department of Developmental Biology VIB7 for Biotechnology VIB and Laboratory of Molecular Biology Celgen, University of Leuven, B 3000 Leuven, Belgium
    Development 133:3399-409. 2006
    ..These results support a model in which loss of Smad5 results paradoxically in gain of Bmp function defects in the amnion...
  26. doi Impaired capsule formation of tumors in periostin-null mice
    Masashi Shimazaki
    Department of Biological Information, Tokyo Institute of Technology, 4259 B 33 Nagatsuta, Midori ku, Yokohama 226 8501, Japan
    Biochem Biophys Res Commun 367:736-42. 2008
    Being a secreted protein, periostin is a multifunctional matricellular glycoprotein. In vitro, periostin has the ability to promote the proliferation and migration of fibroblasts...
  27. ncbi Immunohistochemical localization of periostin in tooth and its surrounding tissues in mouse mandibles during development
    Hironobu Suzuki
    Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, 2 5274 Gakkocho dori, Niigata 951 8514, Japan
    Anat Rec A Discov Mol Cell Evol Biol 281:1264-75. 2004
    Previous reports have shown expression of immunoreactivity for periostin, originally identified as osteoblast-specific factor-2, in the periosteum and periodontal ligament...
  28. ncbi Periostin is expressed within the developing teeth at the sites of epithelial-mesenchymal interaction
    Agnieszka Kruzynska-Frejtag
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, USA
    Dev Dyn 229:857-68. 2004
    b>Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment, and spreading...
  29. ncbi Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration
    Sean C Goetsch
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8573, USA
    Physiol Genomics 14:261-71. 2003
    ..7], the fetal myogenic program (Myod1, Myf5, Myf6), and the biomatrix (procollagen genes, Mmp3, Mmp9, biglycan, periostin) during muscle regeneration...
  30. ncbi Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development
    Nagako Yoshiba
    Division of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cell Tissue Res 330:133-45. 2007
    ..b>Periostin, originally identified in a mouse osteoblastic library, plays a role in cell adhesion and migration and in ..
  31. pmc Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling
    Toru Oka
    Department of Pediatrics, University of Cincinnati, Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Circ Res 101:313-21. 2007
    ..In response to pathologic insults, the adult heart reexpresses the secreted extracellular matrix protein periostin (Pn)...
  32. pmc Periostin is essential for cardiac healing after acute myocardial infarction
    Masashi Shimazaki
    Department of Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    J Exp Med 205:295-303. 2008
    ..We show that periostin, which is a matricellular protein, is important for the cardiac healing process after AMI...
  33. ncbi Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta
    K Horiuchi
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    J Bone Miner Res 14:1239-49. 1999
    ..Based on this observation and the fact that other proteins have been called OSF-2, the protein was renamed "periostin." Western blot analysis showed that periostin is a disulfide linked 90 kDa protein secreted by osteoblasts and ..
  34. ncbi Comparison of the four mouse fasciclin-containing genes expression patterns during valvuloseptal morphogenesis
    Andrew Lindsley
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, 46202, USA
    Gene Expr Patterns 5:593-600. 2005
    ..comparison of the fasciclin-containing secreted adhesion genes, TGFbeta induced clone H3 (betaigH3) and periostin, revealed that they are co-localized within the outflow tract endocardial cushions, but that betaigH3 expression ..
  35. ncbi BMP signaling is required for septation of the outflow tract of the mammalian heart
    Emmanuèle C Délot
    Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Development 130:209-20. 2003
    ..The more restricted spectrum of cardiac anomalies in Bmpr2(deltaE2) mutants makes this strain a key murine model to understand the embryonic defects of persistent truncus arteriosus and impaired semilunar valve formation in humans...
  36. ncbi Periostin (an osteoblast-specific factor) is expressed within the embryonic mouse heart during valve formation
    A Kruzynska-Frejtag
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, USA
    Mech Dev 103:183-8. 2001
    b>Periostin was originally isolated as a osteoblast-specific factor that functions as a cell adhesion molecule for preosteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading...
  37. pmc Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase
    Jonathan T Butcher
    Cardiovascular Developmental Biology Center, Chair of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA
    Dev Biol 302:256-66. 2007
    ..We have previously identified the spatiotemporal expression patterns of periostin in developing valves, but its function during this process is largely unknown...
  38. pmc Periostin is induced in glomerular injury and expressed de novo in interstitial renal fibrosis
    Kontheari Sen
    Institute of Physiology and Division of Nephrology, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Am J Pathol 179:1756-67. 2011
    ..b>Periostin showed the highest induction, and its transcript levels correlated negatively with glomerular filtration rate in ..
  39. pmc periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype
    Hector Rios
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    Mol Cell Biol 25:11131-44. 2005
    b>Periostin was originally identified as an osteoblast-specific factor and is highly expressed in the embryonic periosteum, cardiac valves, placenta, and periodontal ligament as well as in many adult cancerous tissues...
  40. doi Expression patterns and roles of periostin during kidney and ureter development
    Katrina Sorocos
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Monash University, Melbourne, Victoria, Australia
    J Urol 186:1537-44. 2011
    b>Periostin is a secreted extracellular matrix protein that is differentially expressed in the developing kidney...
  41. pmc Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase
    Takumi Maruhashi
    Department of Biological Information, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 285:13294-303. 2010
    ..Here we show that periostin, a secretory protein in the dense connective tissues, promotes the activation of LOX...
  42. pmc Differential activation of valvulogenic, chondrogenic, and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease
    Jonathan D Cheek
    The Heart Institute, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    J Mol Cell Cardiol 52:689-700. 2012
    ..b>Periostin null mice also exhibit dysregulation of the ECM with thickening in the aortic midvalve region, but do not have ..
  43. pmc Periostin downregulation is an early marker of inhibited neonatal murine lung alveolar septation
    Shawn K Ahlfeld
    Developmental Biology and Neonatal Medicine Program, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Birth Defects Res A Clin Mol Teratol 97:373-85. 2013
    ..Prolonged hyperoxic lung injury has previously been shown to upregulate the matricellular protein Periostin (Postn) and stimulate ectopic accumulation of alpha smooth muscle actin (αSMA) myofibroblasts...
  44. pmc Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis
    Xiaoqiang Cai
    Department of Developmental and Regenerative Biology, The Mindich Child Health and Development Institute, and The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
    Development 140:3176-87. 2013
    ..Our study suggests a model in which Tbx20 regulates the Wnt pathway to direct endocardial cushion maturation and valve elongation, and provides new insights into the etiology of valve defects in humans. ..
  45. doi Histochemical examination of cathepsin K, MMP1 and MMP2 in compressed periodontal ligament during orthodontic tooth movement in periostin deficient mice
    Shengyu Lv
    Shandong Provincial Key Laboratory of Oral Biomedicine, Department of Bone Metabolism, School of Stomatology, Shandong University, Wenhua West Road 44 1, Jinan, 250012, China
    J Mol Histol 45:303-9. 2014
    ..MMP) 1 and 2 in the compressed periodontal ligament (PDL) during orthodontic tooth movement using a periostin deficient (Pn-/-) mouse model...
  46. pmc Periostin responds to mechanical stress and tension by activating the MTOR signaling pathway
    Luciana K Rosselli-Murai
    Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e83580. 2013
    Current knowledge about Periostin biology has expanded from its recognized functions in embryogenesis and bone metabolism to its roles in tissue repair and remodeling and its clinical implications in cancer...
  47. doi Adipocyte-Derived Hormone Leptin Is a Direct Regulator of Aldosterone Secretion, Which Promotes Endothelial Dysfunction and Cardiac Fibrosis
    Anne Cécile Huby
    From Physiology Department, Medical College of Georgia at Georgia Regents University, Augusta A C H, G A, J G, W B B, J A F, E J D d C Charlie Norwood VA Medical Center, Augusta, GA W B B Endocrine Section, G V Sonny Montgomery VA Medical Center, and University of Mississippi Medical Center, Jackson C E G S
    Circulation 132:2134-45. 2015
    ..We hypothesized that the adipokine leptin is a direct regulator of aldosterone synthase (CYP11B2) expression and aldosterone release and promotes cardiovascular dysfunction via aldosterone-dependent mechanisms...
  48. doi Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1α/IL-6 loop
    Kazuto Taniguchi
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Invest Dermatol 134:1295-304. 2014
    ..Epithelial-mesenchymal interaction affects this event via the cross-talk of cytokines and growth factors. Periostin, a matricellular protein, has an important role during reepithelialization in wound healing and is critical for ..
  49. pmc Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis
    Kazuhiko Arima
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    Allergol Int 64:41-8. 2015
    ..We previously showed that periostin, a matricellular protein, plays a critical role in epidermal hyperplasia in AD, using a mouse model and a 3-..
  50. doi Periostin induces pancreatic regeneration
    Johnathan K Smid
    Sprott Center for Stem Cell Research J K S, S F, M A R, Ottawa Hospital Research Institute, Regenerative Medicine Program, and University of Ottawa J K S, M A R, Cellular and Molecular Medicine, Faculty of Medicine, Ottawa, Ontario, Canada K1H 8L6
    Endocrinology 156:824-36. 2015
    We found that the secreted protein periostin (Postn) is highly induced after partial pancreatectomy in regenerating areas containing mesenchymal stroma and tubular complexes...
  51. pmc Periostin is required for maximal airways inflammation and hyperresponsiveness in mice
    J Kelley Bentley
    Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Mich
    J Allergy Clin Immunol 134:1433-42. 2014
    b>Periostin, a secreted extracellular matrix protein, has been localized to deposits of subepithelial fibrosis in asthmatic patients, and periostin levels have been linked to increases in IL-13.
  52. pmc Imbalanced expression of Vcan mRNA splice form proteins alters heart morphology and cellular protein profiles
    Tara A Burns
    Departments of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, United States of America
    PLoS ONE 9:e89133. 2014
    ....
  53. doi Altered distribution of extracellular matrix proteins in the periodontal ligament of periostin-deficient mice
    Chihiro Tabata
    Departments of Developmental Biology of Hard Tissue and Orthodontics, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan
    Histol Histopathol 29:731-42. 2014
    Verifying whether periostin affects the distribution of type I collagen, fibronectin and tenascin C in the periodontal ligament (PDL) is important to contribute to a more thorough understanding of that protein's functions...
  54. doi Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones
    Paritosh Prashar
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh, India
    Dev Biol 389:192-207. 2014
    ....
  55. pmc Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling
    Christopher L Smith
    Department of Molecular Biology, MC9148, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Circ Res 108:e15-26. 2011
    ..Therefore, we investigated the combined and independent roles of these receptors in epicardial development...
  56. pmc Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis
    Masaru Uchida
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, 5 1 1 Nabeshima, Saga, Japan
    Am J Respir Cell Mol Biol 46:677-86. 2012
    ..b>Periostin is a recently characterized matricellular protein involved in modulating cell functions...
  57. pmc Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
    Paul Delgado-Olguín
    Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
    Nat Genet 44:343-7. 2012
    ..Our results suggest that epigenetic dysregulation in embryonic progenitor cells is a predisposing factor for adult disease and dysregulated stress responses...
  58. doi Role of central nervous system periostin in cerebral ischemia
    Munehisa Shimamura
    Department of Clinical Gene Therapy, Osaka University, Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    Stroke 43:1108-14. 2012
    Although periostin, an extracellular matrix glycoprotein, plays pivotal roles in survival, migration, and regeneration in various cells, its expression and function in the brain are still unknown...
  59. pmc Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart
    Andy Wessels
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA
    Dev Biol 366:111-24. 2012
    ....
  60. pmc The bHLH transcription factor Tcf21 is required for lineage-specific EMT of cardiac fibroblast progenitors
    Asha Acharya
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 139:2139-49. 2012
    ..We demonstrate a unique role for Tcf21 in multipotent epicardial progenitors, prior to the process of EMT that is essential for cardiac fibroblast development...
  61. pmc Periostin promotes chronic allergic inflammation in response to Th2 cytokines
    Miho Masuoka
    Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga, Japan
    J Clin Invest 122:2590-600. 2012
    ..The mechanisms underlying chronicity in allergic inflammation remain unresolved. Periostin, a recently characterized matricellular protein, interacts with several cell surface integrin molecules, ..
  62. pmc Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development
    Ralston M Barnes
    Riley Heart Research Center, Wells Center for Pediatric Research, Division of Pediatric Cardiology, Departments of Anatomy and Medical and Molecular Genetics, Indiana Medical School, Indianapolis, 46202 5225, USA
    Circ Res 108:940-9. 2011
    ..The basic helix-loop-helix (bHLH) transcription factors Hand1 and Hand2 are essential for embryonic development. Given their requirement for cardiogenesis, it is imperative to determine their impact on cardiovascular function...
  63. ncbi Suppression of anchorage-independent growth of human cancer cell lines by the TRIF52/periostin/OSF-2 gene
    Naohisa Yoshioka
    Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, Suita, 565 0871, Japan
    Exp Cell Res 279:91-9. 2002
    ..One of these genes, TRIF52, is a rat homologue of the mouse protein periostin, which is suspected of being involved in oncogenesis...
  64. ncbi Expression and characterization of murine osteoblast-specific factor 2 (OSF-2) in a baculovirus expression system
    T Sugiura
    Laboratory of Molecular Biology, Hoechst Japan Limited, Saitama
    Protein Expr Purif 6:305-11. 1995
    ..The establishment of the baculovirus expression system with a high productivity of recombinant OSF-2 (around 40 micrograms/ml at maximum) and its heparin binding properties should allow us to obtain large amounts of rmOSF-2...
  65. pmc Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation
    Pablo Villavicencio-Lorini
    Max Planck Institute for Molecular Genetics, Berlin, Germany
    J Clin Invest 120:1994-2004. 2010
    ..These data indicate that Hox genes not only regulate patterning but also directly influence bone formation and the ossification pattern of bones, in part via Runx2...
  66. doi PDGF-B signaling is important for murine cardiac development: its role in developing atrioventricular valves, coronaries, and cardiac innervation
    Nynke M S Van Den Akker
    Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands
    Dev Dyn 237:494-503. 2008
    ..Immunohistochemical staining for alphaSMA, periostin, ephrinB2, EphB4, VEGFR-2, Dll1, and NCAM was performed on wild-type and knockout embryos...
  67. pmc Lineage-specific responses to reduced embryonic Pax3 expression levels
    Hong Ming Zhou
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Dev Biol 315:369-82. 2008
    ..Thus, we have established that there are different minimum threshold requirements for Pax3 within different Pax3-expressing lineages...
  68. pmc Periostin regulates atrioventricular valve maturation
    Russell A Norris
    Department of Cell Biology and Anatomy, Medical University of South Carolina, BSB Suite 601, 173 Ashley Avenue, Charleston, SC 29425, USA
    Dev Biol 316:200-13. 2008
    ..Expression analyses, presented in this report, demonstrate that periostin, a component of the extracellular matrix, is predominantly expressed in post-EMT valve tissues and their ..
  69. pmc Immunolocalization of Periostin-like factor and Periostin during embryogenesis
    Shimei Zhu
    Department of Anatomy and Cell Biology, Temple Medical School, 3420 N Broad Street, MRB 615, Philadelphia, PA 19140, USA
    J Histochem Cytochem 56:329-45. 2008
    b>Periostin-like factor (PLF) and Periostin are alternatively spliced mRNAs. Our findings are the first to show similarities and differences between PLF and Periostin location using isoform-specific antibodies...
  70. pmc Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo
    Agata K Levay
    Department of Molecular and Cellular Pharmacology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Circ Res 103:948-56. 2008
    ..Collectively, our studies have identified an in vivo requirement for scx during valvulogenesis and demonstrate its role in cell lineage differentiation and matrix distribution in remodeling valve structures...
  71. pmc Genetic manipulation of periostin expression in the heart does not affect myocyte content, cell cycle activity, or cardiac repair
    Angela Lorts
    Department of Pediatrics, Division of Cardiology, University of Cincinnati, Cincinnati Children s Hospital Medical Center, Ohio, USA
    Circ Res 104:e1-7. 2009
    ..b>Periostin, an extracellular matrix protein, has recently been proposed to induce reentry of differentiated cardiomyocytes ..
  72. pmc Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer
    Andrew Lindsley
    Cardiovascular Development Group, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Dev Biol 307:340-55. 2007
    b>Periostin is a fasciclin-containing adhesive glycoprotein that facilitates the migration and differentiation of cells that have undergone epithelial-mesenchymal transformation during embryogenesis and in pathological conditions...
  73. pmc Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling
    Masaki Ieda
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, 94158, USA
    Dev Cell 16:233-44. 2009
    ..These findings reveal a previously unrecognized paracrine function of embryonic cardiac fibroblasts in regulating cardiomyocyte proliferation...
  74. pmc Generation of Smad7(-Cre) recombinase mice: A useful tool for the study of epithelial-mesenchymal transformation within the embryonic heart
    Paige Snider
    Riley Heart Research Center, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, 46202, USA
    Genesis 47:469-75. 2009
    ..Ablation of Smad7(Cre) cells resulted in embryonic lethality by E11.5 and largely acellular endocardial cushions...
  75. ncbi Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties
    Mitsutaka Shiota
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Exp Cell Res 313:1008-23. 2007
    ..RT-PCR analysis also revealed that the spheres were positive for nestin in addition to PPARgamma, osf2, SOX9, and myoD, which are markers of precursors of adipocytic, osteoblastic, chondrocytic, and skeletal ..
  76. pmc Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects
    K Mesbah
    Laboratoire EGDM, CNRS URA 2578, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Cell Biol 26:7760-71. 2006
    ....
  77. pmc Periostin is a novel factor in cardiac remodeling after experimental and clinical unloading of the failing heart
    William E Stansfield
    Division of Cardiothoracic Surgery, Department of Surgery, University of North Carolina, Chapel Hill, North Carolina, USA
    Ann Thorac Surg 88:1916-21. 2009
    ..Originally evaluated in the context of bone development, periostin is important in endocardial cushion formation and has recently been implicated in heart failure...
  78. doi Role of periostin in cancer progression and metastasis: inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model
    Mariko Kyutoku
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Int J Mol Med 28:181-6. 2011
    b>Periostin (PN), a secreted adhesion-related protein expressed in the periosteum and periodontal ligaments, acts as a critical regulator of the formation and maintenance of bone and teeth, and also plays an important role in tumorigenesis...
  79. ncbi Periostin and periostin-like factor in the human heart: possible therapeutic targets
    Judith Litvin
    Cardiovascular Research Group, Temple University Medical School, Philadelphia, PA 19140, USA
    Cardiovasc Pathol 15:24-32. 2006
    ..A family of proteins, which includes periostin and periostin-like factor (PLF), has been identified during heart development and disease...
  80. pmc Gene expression in the efferent ducts, epididymis, and vas deferens during embryonic development of the mouse
    Elizabeth M Snyder
    Center for Reproductive Biology, School of Molecular Biosciences, Washington State University, Pullman, Washington, USA
    Dev Dyn 239:2479-91. 2010
    ..Immunofluorescence localization of the cell adhesion regulators POSTN and CDH2 demonstrated cell adhesion in the epithelium and mesenchyme of the epididymis may change throughout ..
  81. doi Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone
    Dario Fortunati
    Department of Biochemistry, Institute of Basic Medical Sciences, PO Box 1112 Blindern, University of Oslo, N 0317 Oslo, Norway
    Matrix Biol 29:594-601. 2010
    b>Periostin is a 90 kDa secreted protein, originally identified in murine osteoblast-like cells, with a distribution restricted to collagen-rich tissues and certain tumors...
  82. pmc Alk3/Bmpr1a receptor is required for development of the atrioventricular canal into valves and annulus fibrosus
    Vinciane Gaussin
    Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 S Orange Ave, MSB Room G 609, Newark, NJ 07103, USA
    Circ Res 97:219-26. 2005
    ..In conclusion, our mouse model demonstrated critical roles for Alk3 signaling in the AV myocardium during the development of AV valves and the annulus fibrosus...
  83. pmc Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-β
    Polakit Teekakirikul
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 120:3520-9. 2010
    ..cells isolated from HCM mouse hearts showed increased levels of RNAs encoding cell-cycle proteins, Tgf-β, periostin, and other profibrotic proteins...
  84. pmc Spatiotemporal localization of periostin and its potential role in epithelial-mesenchymal transition during palatal fusion
    Yukiko Kitase
    Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, B C, Canada
    Cells Tissues Organs 193:53-63. 2011
    ..Extracellular matrix components have been shown to play an important role in EMT in many model systems. Periostin (also known as osteoblast-specific factor-2) is a secreted mesenchymal extracellular matrix component that ..
  85. pmc skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration
    Chong Yon Park
    Department of Pediatrics, Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 107:20750-5. 2010
    ..Our results indicate that skNAC plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration in mice...
  86. pmc A novel role of periostin in postnatal tooth formation and mineralization
    Dedong Ma
    Department of Respiratory Medicine, Qilu Hospital, Shandong University, Jinan 250012, China
    J Biol Chem 286:4302-9. 2011
    b>Periostin plays multiple functions during development. Our previous work showed a critical role of this disulfide-linked cell adhesion protein in maintenance of periodontium integrity in response to occlusal load...
  87. pmc Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice
    Wim T J Aanhaanen
    Heart Failure Research Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 121:534-44. 2011
    ..Our results suggest that malformation of the annulus fibrosus and preexcitation arise from the disturbed development of the atrioventricular myocardium...
  88. pmc In vitro requirement for periostin in B lymphopoiesis
    Basile T Siewe
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S First Ave, Maywood, IL 60153, USA
    Blood 117:3770-9. 2011
    ..from young and adult rabbits showed that expression of Postn that encodes for the extracellular matrix protein periostin dramatically reduced with age...
  89. pmc The basement membrane of hair follicle stem cells is a muscle cell niche
    Hironobu Fujiwara
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, UK
    Cell 144:577-89. 2011
    ..Thus, bulge stem cells, via nephronectin expression, create a smooth muscle cell niche and act as tendon cells for the APM. Our results reveal a functional role for basement membrane heterogeneity in tissue patterning. PAPERCLIP:..
  90. doi Accessory atrioventricular myocardial pathways in mouse heart development: substrate for supraventricular tachycardias
    Nathan D Hahurij
    Department of Pediatric Cardiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands
    Pediatr Res 70:37-43. 2011
    ..and immunohistochemical analyses with antibodies specifically against atrial myosin light chain 2 (MLC-2a), Periostin, Nkx2.5, and Connexin-43 were performed in embryonic mouse hearts ranging from 11.5 to 18...
  91. doi Deafness in mice lacking the T-box transcription factor Tbx18 in otic fibrocytes
    Mark Oliver Trowe
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Development 135:1725-34. 2008
    ....
  92. ncbi Periostin is down-regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells
    Chul Jang Kim
    Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Int J Cancer 117:51-8. 2005
    We have previously reported that expression of periostin mRNA is markedly reduced in a variety of human cancer cell lines, suggesting that downregulation of periostin mRNA expression is correlated with the development of human cancers...

Research Grants2

  1. The Role of Cartilage Link Protein 1 (Crtl1) in Heart Development
    ARNO WESSELS; Fiscal Year: 2010
    ..Understanding the role of Crtl1, and Crtl1-associated mechanisms, in heart development may further our knowledge of the etiology of a variety of these malformations including the mechanisms that lead to muscular septal defects. ..
  2. Role of ALK3 in atrioventricular valve development
    Vinciane Gaussin; Fiscal Year: 2008
    ..5-E15.5, with the premature disappearance of the myocardial layer in the tricuspid mural leaflet, and defective periostin expression...

Patents1

  1. NOVEL PROTEIN HAVING OSTEOGENIC ACTION AND ITS PRODUCTION
    Patent Number: JP1993268982-A; Date:1993-10-19