Pomc

Summary

Gene Symbol: Pomc
Description: pro-opiomelanocortin-alpha
Alias: ACTH, Beta-LPH, Clip, Gamma-LPH, Npp, Pomc-1, Pomc1, alpha-MSH, alphaMSH, beta-MSH, gamma-MSH, pro-opiomelanocortin, adrenal corticotropic hormone, adrenocorticotropic hormone, alpha-melanocyte stimulating hormone, beta-endorphin, corticotropin-like intermediary peptide, corticotropin-lipotropin, melanotropin gamma, met-enkephalin
Species: mouse

Top Publications

  1. ncbi The proopiomelanocortin gene is expressed as both full-length and 5'truncated transcripts in rodent Leydig cells
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Reprod Fertil Dev 6:791-4. 1994
  2. ncbi Endocrine response to surgical stress and postoperative confusion in depressed patients with alcohol abuse
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Aomori, Japan
    Neuropsychobiology 50:195-9. 2004
  3. pmc Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting
    Flavio S J de Souza
    INGEBI CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
    Mol Cell Biol 25:3076-86. 2005
  4. ncbi Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling
    Heike Munzberg
    Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:69-74. 2007
  5. doi FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
    Guoqing Yang
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667
    J Biol Chem 284:3719-27. 2009
  6. pmc MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression
    Zichao Zhang
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 285:34718-28. 2010
  7. pmc Spatial and temporal localization of the melanocortin 1 receptor and its ligand α-melanocyte-stimulating hormone during cutaneous wound repair
    Lara A Muffley
    Department of Surgery, University of Washington, Seattle, Washington 98104, USA
    J Histochem Cytochem 59:278-88. 2011
  8. ncbi Nur77 induction and activation are necessary for interleukin-1 stimulation of proopiomelanocortin in AtT-20 corticotrophs
    Damian Kovalovsky
    Departamento de Fisiologia y Biologia Molecular, FCEN, Universidad de Buenos Aires and CONICET, Buenos Aires, Argentina
    FEBS Lett 563:229-33. 2004
  9. doi Prenylated Rab acceptor domain family member 1 is involved in stimulated ACTH secretion and inhibition
    Shannon L Compton
    Pioneer Valley Life Sciences Institute, Springfield, MA 01199, United States
    Cell Signal 21:1901-9. 2009
  10. ncbi Expression of syndecan-1 inhibits cell invasion into type I collagen
    B F Liebersbach
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72205
    J Biol Chem 269:20013-9. 1994

Research Grants

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. ncbi The proopiomelanocortin gene is expressed as both full-length and 5'truncated transcripts in rodent Leydig cells
    R Ivell
    Institute for Hormone and Fertility Research, University of Hamburg, Germany
    Reprod Fertil Dev 6:791-4. 1994
    ..between full-length transcripts and functionally aberrant, truncated transcripts of the proopiomelanocortin (POMC) gene...
  2. ncbi Endocrine response to surgical stress and postoperative confusion in depressed patients with alcohol abuse
    Akira Kudoh
    Department of Anesthesiology, Hirosaki National Hospital, Hirosaki, Aomori, Japan
    Neuropsychobiology 50:195-9. 2004
    ..We investigated the incidence of postoperative confusion, plasma cortisol and ACTH response to surgical stress in depressed patients with alcohol abuse...
  3. pmc Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting
    Flavio S J de Souza
    INGEBI CONICET, Vuelta de Obligado 2490, 1428 Buenos Aires, Argentina
    Mol Cell Biol 25:3076-86. 2005
    The proopiomelanocortin (POMC) gene is expressed in the pituitary and arcuate neurons of the hypothalamus...
  4. ncbi Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling
    Heike Munzberg
    Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:69-74. 2007
    ..in s/s animals suggested that leptin appropriately suppresses the frequency of IPSCs on ARC proopiomelanocortin (POMC) neurons that are mediated by the release of GABA from orexigenic ARC neurons...
  5. doi FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1
    Guoqing Yang
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667
    J Biol Chem 284:3719-27. 2009
    ..To understand the molecular mechanisms of leptin resistance, we studied the regulation of pro-opiomelanocortin (POMC) gene expression by leptin...
  6. pmc MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression
    Zichao Zhang
    Center for Environmental and Genetic Medicine, Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77030, USA
    J Biol Chem 285:34718-28. 2010
    ..This study demonstrates that microRNAs are critical for anterior pituitary development and that miR-26b regulates Pit-1 expression by inhibiting Lef-1 expression and may promote Pit-1 lineage differentiation during pituitary development...
  7. pmc Spatial and temporal localization of the melanocortin 1 receptor and its ligand α-melanocyte-stimulating hormone during cutaneous wound repair
    Lara A Muffley
    Department of Surgery, University of Washington, Seattle, Washington 98104, USA
    J Histochem Cytochem 59:278-88. 2011
    ..This article contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  8. ncbi Nur77 induction and activation are necessary for interleukin-1 stimulation of proopiomelanocortin in AtT-20 corticotrophs
    Damian Kovalovsky
    Departamento de Fisiologia y Biologia Molecular, FCEN, Universidad de Buenos Aires and CONICET, Buenos Aires, Argentina
    FEBS Lett 563:229-33. 2004
    Nur77 and Nurr1 are critical for proopiomelanocortin (POMC) regulation by corticotrophin releasing hormone (CRH) in corticotrophs...
  9. doi Prenylated Rab acceptor domain family member 1 is involved in stimulated ACTH secretion and inhibition
    Shannon L Compton
    Pioneer Valley Life Sciences Institute, Springfield, MA 01199, United States
    Cell Signal 21:1901-9. 2009
    ..to corticotrophin-releasing hormone and Dex, upregulated expression of the ACTH prohormone pro-opiomelanocortin (POMC), altered POMC processing, and altered Golgi complex morphology with decreased intra-Golgi and intracellular co-..
  10. ncbi Expression of syndecan-1 inhibits cell invasion into type I collagen
    B F Liebersbach
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock 72205
    J Biol Chem 269:20013-9. 1994
    ..These results demonstrate that expression of syndecan-1 inhibits cell invasion into collagen and that loss of syndecan-1 expression may be necessary prior to the migration of normal or metastatic cells...
  11. doi PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..protein kinase-1 (PDK-1)/protein kinase B (PKB, also known as Akt) in proopiomelanocortin (POMC) neurons. Forkhead box-containing protein-O1 (FoxO1) is inactivated in a PI(3)K-dependent manner...
  12. ncbi Targeted ablation of pituitary pre-proopiomelanocortin cells by herpes simplex virus-1 thymidine kinase differentially regulates mRNAs encoding the adrenocorticotropin receptor and aldosterone synthase in the mouse adrenal gland
    R G Allen
    Center for Research on Occupational and Environmental Toxicology, Vollum Institute, Oregon Health Sciences University, Portland 97201, USA
    Mol Endocrinol 9:1005-16. 1995
    ..corticotropes were ablated as determined by immunocytochemistry and RIA specific for the POMC-derived peptides, ACTH, beta-endorophin, and alpha-MSH...
  13. ncbi Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice
    M S Deiner
    Departments of Ophthalmology and Physiology, Biomedical Sciences Program, Beckman Vision Center, University of California, San Francisco, San Francisco, California 94143 0730, USA
    J Neurosci 19:9900-12. 1999
    ..Netrin protein localization also indicates that unlike in more caudal CNS, guidance about the hypothalamic ventral midline does not require midline expression of netrin...
  14. ncbi In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development
    M A Japón
    Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland
    J Histochem Cytochem 42:1117-25. 1994
    ..5 (E9.5) to postnatal Day 1 (P1). Pro-opiomelanocortin (POMC) mRNA was expressed in the basal diencephalon on Day E10...
  15. ncbi Specification of pituitary cell lineages by the LIM homeobox gene Lhx3
    H Z Sheng
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Science 272:1004-7. 1996
    ..The determination of all pituitary cell lineages, except the corticotrophs, was affected, suggesting that a distinct, Lhx3-independent ontogenetic pathway exists for the initial specification of this lineage...
  16. ncbi Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene
    D J Good
    Acquired Gene Rearrangement Section, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20889, USA
    Nat Genet 15:397-401. 1997
    ..Nhlh2 is expressed in the ventral-medial and lateral hypothalamus, Rathke's pouch and in the anterior lobe of the adult pituitary. Our results support a role for Nhlh2 in the onset of puberty and the regulation of body weight metabolism...
  17. ncbi Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary
    J Ericson
    Department of Microbiology, Umea, University, S 901 87 Umea, Sweden
    Development 125:1005-15. 1998
    ..BMPs, in contrast, have no apparent effect on cell proliferation but instead appear to act with FGFs to control the initial selection of thyrotroph and corticotroph progenitor identity...
  18. ncbi Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
    L Yaswen
    Unit on Molecular Genetics, Clinical Neuroscience Branch, NIMH, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Med 5:1066-70. 1999
    Pro-opiomelanocortin (POMC)-derived peptides (the melanocortins adrenocorticotropin, alpha-, beta- and gamma-melanocyte stimulating hormone; and the endogenous opioid beta-endorphin) have a diverse array of biological activities, ..
  19. ncbi Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice
    H Makimura
    Fishberg Center for Neurobiology, Department of Geriatrics, Mount Sinai School of Medicine, New York, New York, USA
    Diabetes 49:1917-23. 2000
    ..Relative to lean controls, ob/ob mice also exhibit decreased hypothalamic proopiomelanocortin (POMC) mRNA and increased hypothalamic agouti-related peptide (AGRP) mRNA and neuropeptide Y (NPY) mRNA...
  20. ncbi Activation of central melanocortin pathways by fenfluramine
    Lora K Heisler
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Science 297:609-11. 2002
    ..These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments...
  21. ncbi TCF and Groucho-related genes influence pituitary growth and development
    Michelle L Brinkmeier
    Department of Human Genetics, University of Michigan Medical School, 4301 MSRBIII, Ann Arbor, Michigan 48109 0638, USA
    Mol Endocrinol 17:2152-61. 2003
    ..Thus, we demonstrate that Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Prop1...
  22. ncbi Altered glucose homeostasis in proopiomelanocortin-null mouse mutants lacking central and peripheral melanocortin
    Ute Hochgeschwender
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104
    Endocrinology 144:5194-202. 2003
    ..We tested this in a mouse model where the proopiomelanocortin (POMC) gene encoding all of the melanocortins has been genetically deleted...
  23. ncbi The effects of proopiomelanocortin deficiency on murine adrenal development and responsiveness to adrenocorticotropin
    Anthony P Coll
    Department of Medicine, Box 232, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
    Endocrinology 145:4721-7. 2004
    The mature adrenal cortex is dependent upon proopiomelanocortin (POMC)-derived peptides for the maintenance of its size, structure, and endocrine function...
  24. pmc N-acetylation of hypothalamic alpha-melanocyte-stimulating hormone and regulation by leptin
    Li Guo
    Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:11797-802. 2004
    ..The POMC-derived peptide alpha-melanocyte-stimulating hormone (alphaMSH) is a melanocortin 4 receptor agonist, and its potency in reducing energy intake is strongly increased by N-..
  25. ncbi PITX genes are required for cell survival and Lhx3 activation
    Michael A Charles
    4301 MSRB III, 1500 West Medical Center Drive, University of Michigan Medical School, Ann Arbor, MI 48109 0638, USA
    Mol Endocrinol 19:1893-903. 2005
    ..Thus, the combined dosage of these PITX family members is vital for pituitary development, and their persistent coexpression in the adult pituitary suggests a continued role in maintenance of pituitary function...
  26. ncbi Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids
    Anthony P Coll
    University Department of Medicine, Addenbrooke s Hospital, Cambridge CB2 2QR, UK
    Diabetes 54:2269-76. 2005
    Congenital lack of proopiomelanocortin (POMC) causes obesity and glucocorticoid deficiency. The responses of Pomc-/- and wild-type mice to the administration of corticosterone were compared...
  27. pmc Glucocorticoids exacerbate obesity and insulin resistance in neuron-specific proopiomelanocortin-deficient mice
    James L Smart
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Clin Invest 116:495-505. 2006
    Null mutations of the proopiomelanocortin gene (Pomc) cause obesity in humans and rodents, but the contributions of central versus pituitary POMC deficiency are not fully established...
  28. ncbi Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells
    David E G McNay
    Division of Developmental Neurobiology, Medical Research Council, The National Institute of Medical Research, Mill Hill, London NW7 1AA, UK
    Mol Endocrinol 20:1623-32. 2006
    ..Although Mash1 is not required for propiomelanocortin (POMC) expression, it is required for normal development of POMC(+) neurons...
  29. ncbi FOXL2 in the pituitary: molecular, genetic, and developmental analysis
    Buffy S Ellsworth
    The University of Michigan Medical School, 4909 Buhl Building, Ann Arbor, Michigan 48109 0618, USA
    Mol Endocrinol 20:2796-805. 2006
    ..These data place FOXL2 in the hierarchy of pituitary developmental control and suggest a role in regulation of Cga gene expression...
  30. pmc Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production
    Anthony P Coll
    Departments of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2XY, UK
    J Endocrinol 190:515-25. 2006
    Pro-opiomelanocortin (POMC) is a polypeptide precursor that undergoes extensive processing to yield a range of peptides with biologically diverse functions...
  31. pmc A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in pomc null mice
    Y C Loraine Tung
    Department of Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge CB2 2QR, United Kingdom
    Endocrinology 147:5940-7. 2006
    ..The ligands for these receptors are derived from the prohormone proopiomelancortin (POMC), which is posttranslationally processed to produce a set of melanocortin peptides with a range of activities at ..
  32. ncbi Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding
    Allison W Xu
    Department of Genetics, Stanford University School of Medicine, San Francisco, California 94143, USA
    Endocrinology 148:72-80. 2007
    ..by acting on multiple neuronal subgroups in the hypothalamus, including those that express proopiomelanocortin (Pomc) and agouti-related protein (Agrp)...
  33. ncbi Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks?
    Xavier Fioramonti
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5018, Paul Sabatier University, Toulouse, France
    Diabetes 56:1219-27. 2007
    ..in glucose-inhibited neurons and the neurotransmitter identity (neuropeptide Y [NPY] or pro-opio melanocortin [POMC]) of glucosensing neurons has remained controversial...
  34. pmc Noggin regulates Bmp4 activity during pituitary induction
    Shannon W Davis
    Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 E Catherine St, Ann Arbor, MI 48109 0618, USA
    Dev Biol 305:145-60. 2007
    ..This work demonstrates the importance of attenuating the activity of Bmp signaling during pituitary induction in order to maintain the proper balance of signaling factors necessary for pituitary organogenesis...
  35. ncbi Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity
    Laura E Parton
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 449:228-32. 2007
    ..To address these issues, we disrupted glucose sensing in glucose-excited pro-opiomelanocortin (POMC) neurons via transgenic expression of a mutant Kir6...
  36. ncbi In vivo evidence for inverse agonism of Agouti-related peptide in the central nervous system of proopiomelanocortin-deficient mice
    Virginie Tolle
    Center for the Study of Weight Regulation and Associated Disorders, Oregon Health and Science University, Portland, Oregon, USA
    Diabetes 57:86-94. 2008
    Melanocyte-stimulating hormone (MSH) peptides processed from proopiomelanocortin (POMC) regulate energy homeostasis by activating neuronal melanocortin receptor (MC-R) signaling...
  37. pmc Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice
    Buffy S Ellsworth
    Department of Human Genetics, The University of Michigan, Medical School, 4909 Buhl Bldg, Ann Arbor, MI 48109 0618, USA
    Dev Biol 313:118-29. 2008
    ....
  38. pmc Collective and individual functions of leptin receptor modulated neurons controlling metabolism and ingestion
    Esther van de Wall
    Departments of Medicine and Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 12461, USA
    Endocrinology 149:1773-85. 2008
    ..arcuate nucleus: the agouti gene-related peptide (AgRP)/neuropeptide Y (NPY) neuron and the proopiomelanocortin (POMC) neuron...
  39. pmc Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
    Jennifer W Hill
    Division of Hypothalamic Research, Department of Internal Medicine and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Invest 118:1796-805. 2008
    ..food intake and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons. It has been proposed that leptin action requires PI3K activity...
  40. pmc Proopiomelanocortin expression in both GABA and glutamate neurons
    Shane T Hentges
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523 1617, USA
    J Neurosci 29:13684-90. 2009
    Proopiomelanocortin (POMC) neurons have been intensively studied because of their essential role in regulating energy balance and body weight...
  41. pmc Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits
    Stephanie L Padilla
    Institute of Human Nutrition, Columbia University, New York, New York, USA
    Nat Med 16:403-5. 2010
    ..that might be susceptible to gestational influences in mice, we characterized the ontogeny of proopiomelanocortin (POMC) and neuropeptide Y (NPY) cell populations, which exert opposing influences on food intake and body weight...
  42. doi Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus
    Michelle Pelling
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    Dev Biol 349:406-16. 2011
    ..fate mapping and loss of function studies in mice demonstrate that Ngn3+ progenitors contribute to subsets of POMC, NPY, TH and SF1 neurons and is required for the specification of these neuronal subtypes in the ventral ..
  43. doi A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells
    David Langlais
    Institut de Recherches Cliniques de Montreal, Montreal, QC, H2W 1R7, Canada
    Mol Endocrinol 25:348-59. 2011
    Cell-specific expression of the pituitary proopiomelanocortin (POMC) gene depends on the combination of tissue- and cell-restricted transcription factors such as Pitx1 and Tpit...
  44. pmc Obesity-programmed mice are rescued by early genetic intervention
    Viviana F Bumaschny
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    J Clin Invest 122:4203-12. 2012
    ..early-onset hyperphagia and severe obesity by selectively blocking the expression of the proopiomelanocortin gene (Pomc) in hypothalamic neurons...
  45. pmc Distinct glutamatergic and GABAergic subsets of hypothalamic pro-opiomelanocortin neurons revealed by in situ hybridization in male rats and mice
    Gabor Wittmann
    Department of Medicine, Division of Endocrinology, Tupper Research Institute, Tufts Medical Center, Boston, Massachusetts 02111, USA
    J Comp Neurol 521:3287-302. 2013
    Pro-opiomelanocortin (POMC) and agouti-related protein (AGRP) neurons in the hypothalamus regulate various aspects of energy homeostasis and metabolism...
  46. ncbi Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism
    M W Sornson
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla 92093, USA
    Nature 384:327-33. 1996
    ..These results imply that a cascade of tissue-specific regulators is responsible for the determination and differentiation of specific cell lineages in pituitary organogenesis...
  47. pmc Feedback control of glucocorticoid production is established during fetal development
    H M Reichardt
    Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
    Mol Med 2:735-44. 1996
    ....
  48. pmc Multistep signaling requirements for pituitary organogenesis in vivo
    M Treier
    Howard Hughes Medical Institute, University of California, San Diego, School and Department of Medicine, La Jolla, California 92093 0648 USA
    Genes Dev 12:1691-704. 1998
    ....
  49. pmc Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36)
    B G Challis
    Department of Clinical Biochemistry and Medicine, Cambridge Institute for Medical Research, Addenbrookes Hospital, Cambridge CB2 2XY, United Kingdom
    Proc Natl Acad Sci U S A 101:4695-700. 2004
    Inactivating mutations of the pro-opiomelanocortin (POMC) gene in both mice and humans leads to hyperphagia and obesity...
  50. ncbi UV-induced expression of key component of the tanning process, the POMC and MC1R genes, is dependent on the p-38-activated upstream stimulating factor-1 (USF-1)
    Sébastien Corre
    CNRS UMR 6061 Laboratoire de Génétique et Développement, Faculte de Medecine, Universite de Rennes 1, 2 Avenue du Pr Leon Bernard, 35043 Rennes, France
    J Biol Chem 279:51226-33. 2004
    ..A key component of the tanning process is the UV-mediated induction of the pro-opiomelanocortin (POMC) and MC1R genes encoding the alpha-melanocyte-stimulating hormone and its receptor, respectively, which play a ..
  51. ncbi Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation
    Jonathon N Winnay
    Department of Molecular and Integrative Pysiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
    Mol Endocrinol 20:147-66. 2006
    ..Within the adrenal cortex, ACTH-dependent transcriptional responses, including transcriptional activation of several key steroidogenic enzymes ..
  52. ncbi The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models
    G S Yeo
    Departments of Medicine and Clinical Biochemistry, Cambridge Institute for Medical Research, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    QJM 93:7-14. 2000
    The peptide products of the pro-opiomelanocortin (POMC) gene have established roles in the control of physiological processes as diverse as adrenal steroidogenesis, skin pigmentation, analgesia and inflammation...
  53. ncbi Requirement of thyrotropin-releasing hormone for the postnatal functions of pituitary thyrotrophs: ontogeny study of congenital tertiary hypothyroidism in mice
    N Shibusawa
    First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan
    Mol Endocrinol 14:137-46. 2000
    ..Moreover, reflecting its name, TRH has more critical effects on the pituitary thyrotrophs than on other pituitary hormone-producing cells...
  54. ncbi Hedgehog signaling is required for pituitary gland development
    M Treier
    Howard Hughes Medical Institute, School and Department of Medicine, UCSD, CMMW, Room 345, La Jolla, CA 92093 0648, USA
    Development 128:377-86. 2001
    ..Thus, SHH appears to exert effects on both proliferation and cell-type determination in pituitary gland development...
  55. ncbi alpha-Melanocyte-stimulating hormone induces cell death in mast cells: involvement of NF-kappaB
    Abira Sarkar
    Laboratory of Immunology, Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad 500 076, India
    FEBS Lett 549:87-93. 2003
    ..Overall, our results suggest that NF-kappaB is the key molecule involved in alpha-MSH-mediated cell death and this may help to regulate mast cell-mediated inflammation...
  56. ncbi Role of PROP1 in pituitary gland growth
    Robert D Ward
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109 0638, USA
    Mol Endocrinol 19:698-710. 2005
    ..These studies suggest a mechanism for Prop1 action and an explanation for some of the clinical findings in human patients...
  57. ncbi Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary
    L D Wilson
    Murdoch Childrens Research Institute, Royal Childrens Hospital, Melbourne, VIC 3052, Australia
    Gene Expr Patterns 5:305-11. 2005
    ..Pituitary cell differentiation and morphology appeared normal in the Rgs2 mutant animals, suggesting that other Rgs family members with similar activities may be present in the developing pituitary...
  58. ncbi Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription
    Eric Batsche
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 280:16088-95. 2005
    ..that the product of the retinoblastoma gene, Rb, is particularly limiting in pituitary pro-opiomelanocortin (POMC)-expressing cell lineages. Indeed, in Rb knock-out mice, these cells develop tumors with high frequency...
  59. ncbi Expression and spatio-temporal distribution of differentiation and proliferation markers during mouse adrenal development
    Dominik M Schulte
    Division of Endocrinology and Metabolism, Department of Internal Medicine II, Klinikum der Albert Ludwigs Universität, Freiburg, Germany
    Gene Expr Patterns 7:72-81. 2007
    ..5 until 2 weeks post partum) during mouse adrenal development. In addition, adrenocorticotropin-hormone (ACTH) receptor (melanocortin-2-receptor (MC2-R)) expression was examined by in situ hybridization (ISH) and co-localized ..
  60. pmc Dmbx1 is essential in agouti-related protein action
    Wakako Fujimoto
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Proc Natl Acad Sci U S A 104:15514-9. 2007
    ..Thus, Dmbx1 is essential for various actions of agouti-related protein and plays a role in normal regulation of energy homeostasis and behavior...
  61. pmc Pomc knockout mice have secondary hyperaldosteronism despite an absence of adrenocorticotropin
    Kirsten Berit Linhart
    Division of Endocrinology, Children s Hospital, Boston, MA 02115, USA
    Endocrinology 149:681-6. 2008
    Aldosterone production is controlled by angiotensin II, potassium, and ACTH. Mice lacking Pomc and its pituitary product ACTH have been reported to have absent or low aldosterone levels, suggesting that ACTH is required for normal ..
  62. pmc In vivo multiplex quantitative analysis of 3 forms of alpha melanocyte stimulating hormone in pituitary of prolyl endopeptidase deficient mice
    Bertrand Perroud
    Genome Center and Bioinformatics Program, University of California, Davis, California, USA
    Mol Brain 2:14. 2009
    ..To investigate in vivo effects of prolyl endopeptidase (PREP), a serine protease, on alpha melanocyte stimulating hormone (alpha-MSH), we developed a new mass spectrometry based technique to quantitate, in multiplex, the ..
  63. pmc Use of mutant mouse lines to investigate origin of gonadotropin-releasing hormone-1 neurons: lineage independent of the adenohypophysis
    Hillery Metz
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorder and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Endocrinology 151:766-73. 2010
    ..These results indicate that in mice, GnRH-1 cells develop independent of the adenohypophyseal placode and are associated early with the formation of the nasal placode...
  64. pmc Progenitor cell expansion and organ size of mouse adrenal is regulated by sonic hedgehog
    Chen Che Jeff Huang
    Department of Veterinary Biosciences, University of Illinois, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA
    Endocrinology 151:1119-28. 2010
    ..reached adulthood, their adrenocortex did not undergo compensatory growth in response to a high level of plasma ACTH, and the size of the adrenal remained significantly smaller than the control adrenal...
  65. doi Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded
    Natalia Lyashenko
    Institute of Molecular Pathology, 1030 Vienna, Austria
    Dev Dyn 239:2266-77. 2010
    ..In this study, we report that loss of the orphan receptor Ror1 results in a variety of phenotypic defects within the skeletal and urogenital systems and that Ror1 mutant mice display a postnatal growth retardation phenotype...
  66. doi Suppression of α-MSH and IBMX-induced melanogenesis by cordycepin via inhibition of CREB and MITF, and activation of PI3K/Akt and ERK-dependent mechanisms
    Mei Ling Jin
    Department of Microbiology, Pusan National University, Busan, Republic of Korea
    Int J Mol Med 29:119-24. 2012
    ..These results indicate the role of cordycepin as a potent depigmenting agent for cosmetics...
  67. pmc Disruption of SoxB1-dependent Sonic hedgehog expression in the hypothalamus causes septo-optic dysplasia
    Li Zhao
    Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 22:585-96. 2012
    ..These data indicate that reduced levels of Shh expression in the hypothalamus cause SOD...
  68. pmc [6]-Shogaol inhibits α-MSH-induced melanogenesis through the acceleration of ERK and PI3K/Akt-mediated MITF degradation
    Huey Chun Huang
    Department of Medical Laboratory Science and Biotechnology, College of Health Care, China Medical University, Taichung, Taiwan
    Biomed Res Int 2014:842569. 2014
    ....
  69. pmc Deletion of OTX2 in neural ectoderm delays anterior pituitary development
    Amanda H Mortensen
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 5618, USA and
    Hum Mol Genet 24:939-53. 2015
    ..Otx2 expression early in head development is important for establishing normal craniofacial features including development of the brain, eyes and pituitary gland. ..
  70. pmc Activation of Brainstem Pro-opiomelanocortin Neurons Produces Opioidergic Analgesia, Bradycardia and Bradypnoea
    Serena Cerritelli
    School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD, United Kingdom
    PLoS ONE 11:e0153187. 2016
    ..The β-endorphin in the central nervous system originates from pro-opiomelanocortin (POMC) neurons in the arcuate nucleus and nucleus of the solitary tract (NTS)...
  71. pmc Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis
    Shuping Wen
    Institute for Neural Signal Transduction, Center for Molecular Neurobiology, D 20253 Hamburg, Germany
    Proc Natl Acad Sci U S A 107:16372-7. 2010
    ..Our experiments define a functional role of embryonic GnRH signaling...
  72. pmc Rax is a selector gene for mediobasal hypothalamic cell types
    Fuqu Lu
    Department of Medical Genetics, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 33:259-72. 2013
    ..Rax thus provides a molecular entry point for further study of the ontology and establishment of hypothalamic feeding circuits...
  73. pmc Proopiomelanocortin (POMC) expression and conditioned place aversion during protracted withdrawal from chronic intermittent escalating-dose heroin in POMC-EGFP promoter transgenic mice
    K Niikura
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Neuroscience 236:220-32. 2013
    ..Here, we investigate changes in proopiomelanocortin (POMC) expression at three time points across an extended period of heroin withdrawal in a clinically relevant rodent ..
  74. pmc Corticotropin and beta-endorphin: construction and analysis of recombinant DNA complementary to mRNA for the common precursor
    J L Roberts
    Proc Natl Acad Sci U S A 76:2153-7. 1979
    A cDNA fragment synthesized from mouse mRNA (ACTH/LPH mRNA) that codes for the precursor polypeptide containing corticotropin (ACTH), beta-lipotropin (LPH), and several other peptides has been cloned in bacteria...
  75. ncbi Altered estrogenic modulation of hypothalamic proopiomelanocortin gene expression in aging mice
    J F Nelson
    Department of Physiology, University of Texas Health Science Center, San Antonio 78284 7756
    Ann N Y Acad Sci 663:501-4. 1992
  76. ncbi Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene
    T Lamonerie
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniquesde Montréal, Quebec, Canada
    Genes Dev 10:1284-95. 1996
    ..The first cells to differentiate are those that express the pro-opiomelanocortin (POMC) gene in the anterior pituitary lobe...
  77. ncbi Targeted ablation of cells in the pituitary primordia of transgenic mice
    H L Burrows
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    Mol Endocrinol 10:1467-77. 1996
    ..In spite of the absence of gonadotropes and thyrotropes, the GH and ACTH-producing cells developed normally...
  78. ncbi Obesity, diabetes and functions for proopiomelanocortin-derived peptides
    K G Mountjoy
    Research Centre for Developmental Medicine and Biology, Department of Paediatrics, University of Auckland, New Zealand
    Mol Cell Endocrinol 128:171-7. 1997
    Melanocortin peptides (adrenocorticotropin (ACTH), alpha-,beta-, and gamma-melanocyte stimulating hormone (MSH), and fragments thereof) derived from proopiomelanocortin (POMC) have a diverse array of biological activities, many of which ..
  79. ncbi Involvement of microphthalmia in the inhibition of melanocyte lineage differentiation and of melanogenesis by agouti signal protein
    E Aberdam
    INSERM U385, Biologie et Physiopathologie de la Peau, Faculte de Medecine, 06107 Nice Cedex 2, France
    J Biol Chem 273:19560-5. 1998
    ..of two intercellular signaling molecules that exert opposite actions, alpha-melanocyte-stimulating hormone (alphaMSH) which preferentially increases the synthesis of eumelanins, and agouti signal protein (ASP) whose expression ..
  80. ncbi Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission
    K Nishii
    Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    J Neurosci Res 54:450-64. 1998
    ..These results demonstrate that dopamine neurotransmission is essential for controlling spontaneous and voluntary movement and associative learning during postnatal development through the nigrostriatal and mesocorticolimbic pathways...
  81. ncbi Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25
    D P Cerretti
    Immunex Corporation, 51 University St, Seattle, WA, 98101, USA
    Cytokine 11:541-51. 1999
    ..The gene for TACE/ADAM17 is approximately 50 kb and contains 19 exons. Chromosomal mapping places TACE/ADAM17 on mouse chromosome 12 and human chromosome 2p25...
  82. ncbi Rapid communication: Mapping of the pro-opiomelanocortin (POMC) gene to pig chromosome by linkage analysis using a PCR-RFLP
    L A Messer
    Department of Animal Science, University of Nebraska, Lincoln 68583 0908, USA
    J Anim Sci 79:2241-2. 2001
  83. ncbi Pitx2 is required at multiple stages of pituitary organogenesis: pituitary primordium formation and cell specification
    Hoonkyo Suh
    Neuroscience Program, Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0638, USA
    Development 129:329-37. 2002
    ..The model developed for PITX gene function in pituitary development provides a better understanding of the etiology of Rieger syndrome and may extend to other PITX-sensitive developmental processes...
  84. ncbi Mechanism of sorting proopiomelanocortin and proenkephalin to the regulated secretory pathway of neuroendocrine cells
    Y Peng Loh
    Section on Cellular Neurobiology, Laboratory of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Ann N Y Acad Sci 971:416-25. 2002
    Proopiomelanocortin (POMC) and proenkephalin (PE) are synthesized at the endoplasmic reticulum and transported to the trans-Golgi network (TGN) where they are sorted and packaged into dense-core granules of the regulated secretory pathway ..
  85. ncbi State-dependent modulation of feeding behavior by proopiomelanocortin-derived beta-endorphin
    Malcolm J Low
    Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    Ann N Y Acad Sci 994:192-201. 2003
    ..the opioid peptide beta-endorphin is co-synthesized and released with melanocortins from proopiomelanocortin (POMC) neuronal terminals, we examined the physiological role of beta-endorphin in feeding and energy homeostasis using a ..
  86. ncbi Alpha-melanocyte-stimulating hormone is a peripheral, integrative regulator of glucose and fat metabolism
    Miles B Brennan
    Eleanor Roosevelt Institute for Cancer Research, Denver, Colorado 80206, USA
    Ann N Y Acad Sci 994:282-7. 2003
    ..of glucose and insulin, we investigated the nature of glucose homeostasis in the obese pro-opiomelanocortin (POMC) knockout mouse...
  87. pmc The vasopressin V1b receptor critically regulates hypothalamic-pituitary-adrenal axis activity under both stress and resting conditions
    Akito Tanoue
    Department of Molecular, Cell Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Clin Invest 113:302-9. 2004
    ..receptor is specifically expressed in pituitary corticotrophs and mediates the stimulatory effect of vasopressin on ACTH release...
  88. ncbi Control of ACTH secretion by excitatory amino acids: functional significance and clinical implications
    Daniela Jezova
    Laboratory of Pharmacological Neuroendocrinology, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, Bratislava 83306, Slovakia
    Endocrine 28:287-94. 2005
    The involvement of excitatory amino acids in the control of ACTH release is well established...
  89. ncbi Cell proliferation and vascularization in mouse models of pituitary hormone deficiency
    Robert D Ward
    Graduate Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor 48109 0618, USA
    Mol Endocrinol 20:1378-90. 2006
    ..This suggests that Prop1 and/or Pit1 may be necessary for caspase-3 expression. These studies provide further insight as to the mechanisms of Prop1 and Pit1 action in mice...
  90. ncbi The involvement of the nociceptin receptor in the antinociceptive action of nitrous oxide
    Shugaku Himukashi
    Department of Anesthesia, Kyoto University Hospital, Kyoto, Japan
    Anesth Analg 103:738-41. 2006
    ..and nitrous oxide (70%), intraperitoneal injection of acetic acid resulted in an increase of plasma adrenocorticotropic hormone concentrations in NOP-/- mice but not in NOP+/+ mice...
  91. pmc Peripheral mechanisms contributing to the glucocorticoid hypersensitivity in proopiomelanocortin null mice treated with corticosterone
    Zoi Michailidou
    Endocrine Unit, Queen s Medical Research Institute, Centre for Cardiovascular Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    J Endocrinol 194:161-70. 2007
    Proopiomelanocortin (POMC) deficiency causes severe obesity through hyperphagia of hypothalamic origin...
  92. ncbi Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence
    Viviana F Bumaschny
    Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Mol Endocrinol 21:2738-49. 2007
    ..Key mediators of the stress response are pituitary hormones encoded by the proopiomelanocortin gene (POMC)...
  93. pmc Melanocortin 2 receptor is required for adrenal gland development, steroidogenesis, and neonatal gluconeogenesis
    Dai Chida
    Division of Cell Biology, Center for Experimental Medicine, and Fine Morphology Laboratory, Department of Basic Medical Science, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 104:18205-10. 2007
    b>ACTH (i.e., corticotropin) is the principal regulator of the hypothalamus-pituitary-adrenal axis and stimulates steroidogenesis in the adrenal gland via the specific cell-surface melanocortin 2 receptor (MC2R)...
  94. pmc A model for obesity and gigantism due to disruption of the Ankrd26 gene
    Tapan K Bera
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Proc Natl Acad Sci U S A 105:270-5. 2008
    ..These results show that alterations in an unidentified gene can lead to obesity and identify a molecular target for the treatment of obesity...
  95. doi Loss of the protein NUPR1 (p8) leads to delayed LHB expression, delayed ovarian maturation, and testicular development of a sertoli-cell-only syndrome-like phenotype in mice
    Christina M Million Passe
    Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana 47405, USA
    Biol Reprod 79:598-607. 2008
    ..Therefore, the ovarian and testicular phenotypes may be due to the loss of NUPR1 directly at the gonads...
  96. doi Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors
    Jason Karpac
    Department of Neurobiology, Duke University Medical Center, 421 Research Drive, Durham, NC 27710, USA
    Am J Physiol Endocrinol Metab 295:E446-55. 2008
    ..The main hormone regulating the production of corticosterone is the proopiomelanocortin (POMC)-derived adrenocorticotropic hormone (ACTH)...
  97. doi Corticotropin-releasing factor (CRF) is involved in the acute anorexic effect of alpha-melanocyte-stimulating hormone: a study using CRF-deficient mice
    Shoko Kawashima
    Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, Aomori 036 8562, Japan
    Peptides 29:2169-74. 2008
    ..The results would suggest that alpha-MSH-induced suppression of food intake at late phase was independent of glucocorticoids and CRF...
  98. doi Novel modulators for body weight changes induced by fasting and re-feeding in mice
    Katsunori Nonogaki
    Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 378:249-54. 2009
    ..Thus, social isolation, endogenous beta-endorphin, and age can be novel modulators for body weight changes induced by fasting and re-feeding in mice...
  99. pmc Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism
    Ezat Sajedi
    Neural Development Unit, Institute of Child Health, University College London, London, UK
    Dis Model Mech 1:241-54. 2008
    ..Together, these results suggest that the I26T mutation yields a hypomorphic allele, whereas R160C produces a null allele and, consequently, a more severe phenotype in both mice and humans...
  100. pmc Nicotine anxiogenic and rewarding effects are decreased in mice lacking beta-endorphin
    Jose M Trigo
    Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Neuropharmacology 56:1147-53. 2009
    ..The dissociation between nicotine rewarding properties and physical dependence suggests a differential implication of beta-endorphin in these addictive related responses...
  101. pmc {alpha}MSH and Cyclic AMP elevating agents control melanosome pH through a protein kinase A-independent mechanism
    Yann Cheli
    From INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, Equipe 1, Biology and Pathologies of Melanocytes, F 06204 Nice Cedex 3, France
    J Biol Chem 284:18699-706. 2009
    ..In the present study, we show that the activation of the cAMP pathway by alphaMSH or forskolin leads to an alkalinization of melanosomes and a concomitant regulation of vacuolar ATPases and ion ..

Research Grants6

  1. Genome-wide location analysis of neuronal genes
    Michael Rosenfeld; Fiscal Year: 2007
    ..We believe that with validation of these approaches, technologies developed here will be of widespread utility in neuroscience, particularly in studies of development and neurodegenerative disease. ..
  2. CRH--ENDOCRINE/IMMUNE INTERACTIONS
    CATHERINE KARALIS; Fiscal Year: 2001
    ..The proposed studies will advance the understanding of the pathogenesis of inflammation and autoimmunity, and thus, may provide new insignts for more effective management of autoimmune diseases and endotoxemia. ..
  3. Operant Responding in Opioid-Deficient Mice
    Malcolm Low; Fiscal Year: 2004
    ..abstract_text> ..
  4. Mechanisms of Hormonal Release by Endocrine Cells
    Giulia Baldini; Fiscal Year: 2006
    ..This study of hormone release will help elucidate possible defects underlying endocrine diseases such as Diabetes Mellitus and Cushing syndrome. [unreadable] [unreadable]..
  5. Neurogenesis as a compensatory mechanism to regulate energy balance
    ALLISON XU; Fiscal Year: 2008
    ..The identification of neuronal substrates critical for body weight regulation will lay the groundwork for future therapeutic interventions designed to target these specific neurons. [unreadable] [unreadable] [unreadable]..
  6. Neurochemistry/physiology of proopiomelancortin neurons
    Malcolm Low; Fiscal Year: 2008
    ..project focuses on a key component of the brain[unreadable]s energy balance circuitry, the proopiomelanocortin (POMC) neurons located in the hypothalamus and brainstem...