Pnp

Summary

Gene Symbol: Pnp
Description: purine-nucleoside phosphorylase
Alias: AL024301, AU015798, Np-1, Np-2, Pnp1, purine nucleoside phosphorylase, inosine phosphorylase, inosine-guanosine phosphorylase, purine-nucleoside phosphorylase 1
Species: mouse

Top Publications

  1. ncbi Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man
    K Harper
    Centre d Immunologie, INSERM CNRS de Marseille Luminy, France
    Immunogenetics 28:439-44. 1988
  2. ncbi Secondary loss of deoxyguanosine kinase activity in purine nucleoside phosphorylase deficient mice
    F F Snyder
    Department of Paediatrics, Faculty of Medicine, University of Calgary, Alberta, Canada
    Biochim Biophys Acta 1227:33-40. 1994
  3. ncbi Absence of dGTP accumulation and compensatory loss of deoxyguanosine kinase in purine nucleoside phosphorylase deficient mice
    J P Jenuth
    Department of Paediatrics, University of Calgary, Alberta, Canada
    Adv Exp Med Biol 309:273-6. 1991
  4. pmc Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse
    F F Snyder
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, AB Canada
    Proc Natl Acad Sci U S A 94:2522-7. 1997
  5. pmc hph-1: a mouse mutant with hereditary hyperphenylalaninemia induced by ethylnitrosourea mutagenesis
    V C Bode
    Division of Biology, Kansas State University, Manhattan 66506
    Genetics 118:299-305. 1988
  6. pmc Identification of three alleles for Mus musculus at the Myhc-a locus which co-segregates with Np-2, Tcra and Rib-1 on chromosome 14
    K W Beisel
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68130
    Nucleic Acids Res 17:10519. 1989
  7. pmc Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system
    T N Sato
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110
    Proc Natl Acad Sci U S A 90:9355-8. 1993
  8. doi Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice
    Alireza Mansouri
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Neurobiol Dis 47:201-9. 2012
  9. ncbi Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14
    K Huppi
    Molecular Genetics Section Laboratory of Genetics, NCI NIH Bethesda, Maryland 20892
    Genomics 19:161-2. 1994
  10. ncbi The gene encoding the T-cell receptor alpha-chain maps close to the Np-2 locus on mouse chromosome 14
    Z Dembic
    Nature 314:271-3. 1985

Scientific Experts

  • S S Apte
  • Eyal Grunebaum
  • Alireza Mansouri
  • Cameron Ackerley
  • Chaim M Roifman
  • Taniya Papinazath
  • F F Snyder
  • Ana Toro
  • Matthew J Pugmire
  • Jeffrey Theodore Henderson
  • Sheena A Josselyn
  • Weixian Min
  • Christina J Cole
  • Matthijs van Eede
  • R Mark Henkelman
  • Amos Cohen
  • Suntharalingam Sujiththa
  • Wexian Min
  • J P Jenuth
  • E Arpaia
  • C A Kozak
  • E R Mably
  • Steven E Ealick
  • M R Blackburn
  • C M Roifman
  • I Dalal
  • Y Gu
  • P P Pandolfi
  • R K Mangat
  • A Di Cristofano
  • M Hershfield
  • P Benveniste
  • A Cohen
  • S Kelly
  • K Huppi
  • S Miyazaki
  • G D Billingsley
  • D F Grant
  • T S Rao
  • E Fung
  • B S Vartabedian
  • T N Sato
  • I N Bespalova
  • S K Datta
  • M Wakamiya
  • R E Kellems
  • J H Nadeau
  • F Buttitta
  • R Callahan
  • J L Guenet
  • J E Dilay
  • D Gallahan
  • B A Taylor
  • A Marchetti
  • S Edelhoff
  • P C Isakson
  • J E Womack
  • T Lightfoot
  • H Mischak
  • D A Adler
  • D M Nelson
  • B D Hammock
  • P J Goodfellow
  • J Hanley-Hyde
  • D Simon
  • D W Cox
  • C M Disteche
  • J Goodnight
  • J L Spearow
  • A M Duncan
  • M H Meisler
  • K W Beisel
  • K H Grzeschik
  • A F Shaffer
  • D Siwarski
  • M D Traystman
  • J L Currie
  • D H Storms
  • Q Farjo
  • M Burmeister
  • L C Samuelson
  • K L Audus
  • A Swaroop
  • A U Jackson
  • Y Qin
  • B Mock
  • T Lukey
  • J L Crosby
  • D P Mortlock
  • U Francke

Detail Information

Publications56

  1. ncbi Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man
    K Harper
    Centre d Immunologie, INSERM CNRS de Marseille Luminy, France
    Immunogenetics 28:439-44. 1988
    ..These findings also provide another example of proximity of genes coding for a member of the Ig super-family and a serine esterase...
  2. ncbi Secondary loss of deoxyguanosine kinase activity in purine nucleoside phosphorylase deficient mice
    F F Snyder
    Department of Paediatrics, Faculty of Medicine, University of Calgary, Alberta, Canada
    Biochim Biophys Acta 1227:33-40. 1994
    The T-cell immunodeficiency associated with purine nucleoside phosphorylase (PNP) deficiency in man is believed to be due to the accumulation of dGTP which may be preferentially formed from deoxyguanosine in T-lymphocytes or their ..
  3. ncbi Absence of dGTP accumulation and compensatory loss of deoxyguanosine kinase in purine nucleoside phosphorylase deficient mice
    J P Jenuth
    Department of Paediatrics, University of Calgary, Alberta, Canada
    Adv Exp Med Biol 309:273-6. 1991
  4. pmc Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse
    F F Snyder
    Department of Medical Genetics, Faculty of Medicine, University of Calgary, AB Canada
    Proc Natl Acad Sci U S A 94:2522-7. 1997
    Three point mutations on the Np(b) allele of the purine nucleoside phosphorylase locus in the mouse have been recovered by male germ cell mutagenesis...
  5. pmc hph-1: a mouse mutant with hereditary hyperphenylalaninemia induced by ethylnitrosourea mutagenesis
    V C Bode
    Division of Biology, Kansas State University, Manhattan 66506
    Genetics 118:299-305. 1988
    ..The initial symptomatology of the mutant phenotype suggests this mutant may represent a useful animal model for the study of hyperphenylalaninemia in man...
  6. pmc Identification of three alleles for Mus musculus at the Myhc-a locus which co-segregates with Np-2, Tcra and Rib-1 on chromosome 14
    K W Beisel
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68130
    Nucleic Acids Res 17:10519. 1989
  7. pmc Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system
    T N Sato
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110
    Proc Natl Acad Sci U S A 90:9355-8. 1993
    ....
  8. doi Cerebellar abnormalities in purine nucleoside phosphorylase deficient mice
    Alireza Mansouri
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Neurobiol Dis 47:201-9. 2012
    Inherited defects in purine nucleoside phosphorylase (PNP) cause severe T cell immunodeficiency and progressive neurological dysfunction, yet little is known about the effects of PNP deficiency on the brain...
  9. ncbi Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14
    K Huppi
    Molecular Genetics Section Laboratory of Genetics, NCI NIH Bethesda, Maryland 20892
    Genomics 19:161-2. 1994
    ..We find that the locus encoding pkcd resides proximal to nucleoside phosphorylase (Np-2) and Tcra on mouse chromosome 14 in a region syntenic with human 3p...
  10. ncbi The gene encoding the T-cell receptor alpha-chain maps close to the Np-2 locus on mouse chromosome 14
    Z Dembic
    Nature 314:271-3. 1985
    ..encoding the constant portion of the T-cell receptor alpha-chain and map the gene to chromosome 14 in mouse, close to the gene for purine nucleoside phosphorylase (Np-2) which, in man, has been associated with T-cell immunodeficiencies.
  11. pmc Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene
    A Weydert
    Proc Natl Acad Sci U S A 82:7183-7. 1985
    ..This result is in contrast to that for other contractile protein genes such as the alkali myosin light chain and the actin multigene families, which are dispersed in the genome...
  12. ncbi Gene mapping in the Chinese hamster and conservation of syntenic groups and Q-band homologies between Chinese hamster and mouse chromosomes
    H Satoh
    Cytogenet Cell Genet 39:285-91. 1985
    ....
  13. ncbi Purine nucleoside phosphorylase (Np) in the mouse: linkage relationship of Np-2 to esterase-10 (Es-10) and Np-1 on chromosome 14
    T Lukey
    Biochem Genet 23:347-56. 1985
    An improved method for detecting four Np-1 (purine nucleoside phosphorylase) alleles in mouse erythrocytes by cellulose acetate electrophoresis is described...
  14. ncbi Linkage relationships among eleven biochemical loci in Peromyscus
    W D Dawson
    Biochem Genet 21:1101-14. 1983
    ..These and other known linkage relationships in Peromyscus correspond closely to those of the house mouse, Mus musculus. The available evidence in Peromyscus further supports the concept of linkage conservation by natural selection...
  15. ncbi Assignment of pancreatic ribonuclease gene to mouse chromosome 14
    R W Elliott
    Cytogenet Cell Genet 42:110-2. 1986
    ..Analysis of the congenic strain B10.D2(57N)Sn confirmed this assignment and indicated that Rib-1 is closely linked to the genes encoding the T-cell receptor alpha subunit (Tcra) and nucleoside phosphorylase-2 (Np-2)...
  16. ncbi Genetic variability of purine nucleoside phosphorylase activity in the mouse: relationship to Np-1 and Np-2
    F F Snyder
    Biochem Genet 21:323-32. 1983
    A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range...
  17. ncbi Genetic mapping in mammals: chromosome map of domestic cat
    S J O'Brien
    Science 216:257-65. 1982
    ..Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed...
  18. ncbi Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7
    R L Stallings
    Somatic Cell Genet 7:683-98. 1981
    ..The assignments provide markers for the study of the genetic consequences of chromosomal rearrangements in Chinese hamster cell lines and support the concept of conservation of mammalian autosomal linkage groups...
  19. ncbi cDNA sequence of four purine nucleoside phosphorylase (Np) alleles in the mouse
    J P Jenuth
    Department of Paediatrics, Faculty of Medicine, University of Calgary, Alberta, Canada
    Mamm Genome 4:598-603. 1993
    The molecular basis of four electrophoretic and activity variants of purine nucleoside phosphorylase in the mouse was examined by amplification and sequence analysis of cDNA...
  20. ncbi Chromosomal mapping and expression levels of a mouse soluble epoxide hydrolase gene
    D F Grant
    Department of Entomology and Environmental Toxicology, University of California, Davis, CA 95616
    Pharmacogenetics 4:64-72. 1994
    ..Northern blotting analysis showed that soluble epoxide hydrolase mRNA levels were correlated with the relative level of soluble epoxide hydrolase enzyme activity and soluble epoxide hydrolase protein in all three mouse strains...
  21. ncbi Role of mast cells in calcium ionophore (A23187)-induced peritoneal inflammation in mice
    T S Rao
    Searle Research and Development, St Louis, Missouri 63198
    Inflammation 18:187-92. 1994
    ..These results also suggest that mast cells are required for full expression of inflammatory responses...
  22. ncbi Mapping of the neural retina leucine zipper gene, Nrl, to mouse chromosome 14
    I N Bespalova
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109
    Mamm Genome 4:618-20. 1993
  23. ncbi Regional localization of loci on chromosome 14 using somatic cell hybrids
    G D Billingsley
    Research Institute, Hospital for Sick Children, Toronto, Ont, Canada
    Cytogenet Cell Genet 66:33-8. 1994
    ..This study also defines a hybrid cell panel with seven mapping intervals, that will be useful for further physical mapping of new loci...
  24. ncbi Metabolic and immunologic consequences of limited adenosine deaminase expression in mice
    M R Blackburn
    Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 271:15203-10. 1996
    ..These mice represent the first genetic animal model for ADA deficiency and provide insight into the tissue-specific requirements of ADA...
  25. ncbi The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis
    S S Apte
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 272:25511-7. 1997
    ..The stringent co-expression of these two genes suggests common regulatory pathways that may have important functional implications for the activation of pro-gelatinase A in health and disease...
  26. pmc Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice
    E Arpaia
    Division of Immunology Allergy, Department of Paediatrics, Hospital for Sick Children, The University of Toronto, Ontario, Canada
    J Exp Med 191:2197-208. 2000
    We generated purine nucleoside phosphorylase (PNP)-deficient mice to gain insight into the mechanism of immune deficiency disease associated with PNP deficiency in humans...
  27. pmc Structural analyses reveal two distinct families of nucleoside phosphorylases
    Matthew J Pugmire
    Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, U S A
    Biochem J 361:1-25. 2002
    ..Several research groups have synthesized a variety of nucleoside phosphorylase inhibitors that are at various stages of preclinical and clinical evaluation...
  28. pmc TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice
    Ana Toro
    Infection, Immunity, Injury and Repair Program, Research Institute, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 116:2717-26. 2006
    Defects in purine nucleoside phosphorylase (PNP) enzyme activity result in abnormal nucleoside homeostasis, severe T cell immunodeficiency, neurological dysfunction, and early death...
  29. doi Effects of purine nucleoside phosphorylase deficiency on thymocyte development
    Taniya Papinazath
    Developmental and Stem Cell Biology Program, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    J Allergy Clin Immunol 128:854-863.e1. 2011
    Inherited or acquired defects in purine nucleoside phosphorylase (PNP) impair purine metabolism, as well as the survival and function of T lymphocytes. However, the effects of PNP deficiency on thymocyte development are not well known.
  30. pmc Nucleotide sequence of murine purine nucleoside phosphorylase cDNA
    J P Jenuth
    Department of Medical Biochemistry, University of Calgary, Alberta, Canada
    Nucleic Acids Res 19:1708. 1991
  31. ncbi Nucleoside phosphorylase 2 (Np-2) of mice
    T A Bremner
    Biochem Genet 16:1143-51. 1978
    ..In addition, the Npla allele previously reported only in inbred strains has been observed in one of the species of wild mice (Mus musculus castaneus) studied...
  32. ncbi Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2
    U Francke
    Cytogenet Cell Genet 19:57-84. 1977
    ..Striking examples of norandom segregation of mouse chromosomes were observed in these hybrids with preferential retention of 15 and segregation of 11 and the Y chromosome...
  33. ncbi Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids
    C A Kozak
    Somatic Cell Genet 3:121-33. 1977
  34. ncbi Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14
    J E Womack
    Biochem Genet 15:347-55. 1977
    ..Es-10 was shown to be linked to Np-1, and the following genetic map of Chr 14 was constructed: centromere-(8.9 +/- 4.0 cM)-[Np-1, Wc]-(10.2 +/- 1.9 cM)-Es-10-(15.5 +/- 3.7 cM)-s. The homologous human loci, NP and ES-D, are not linked...
  35. ncbi Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome
    C Kozak
    Somatic Cell Genet 1:371-82. 1975
    ..All other isozymes examined segregated independently of one another...
  36. ncbi Isolation and expression of a murine purine nucleoside phosphorylase-encoding cDNA and sequence similarity with the human message
    D M Nelson
    Institute of Human Genetics, University of Minnesota, Minneapolis 55455
    Gene 113:215-21. 1992
    To isolate murine purine nucleoside phosphorylase-encoding cDNA sequences (PNP), a murine BALB/c liver cDNA library in lambda gt10 was screened for recombinants hybridizing to a human PNP cDNA probe...
  37. ncbi Close linkage of retinoic acid receptor genes with homeobox- and keratin-encoding genes on paralogous segments of mouse chromosomes 11 and 15
    J H Nadeau
    Jackson Laboratory, Bar Harbor, Maine 04609
    Mamm Genome 3:202-8. 1992
    ..We confirmed assignment of retinoic acid receptor beta to the centromeric portion of Chr 14. These linkage assignments provide further evidence for duplicated segments in the mouse genome...
  38. ncbi Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequences
    J Hanley-Hyde
    Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 13:1018-30. 1992
    ..Cycb1-rs6 (on chromosome 13) is discussed as the most likely candidate for an expressed structural gene locus...
  39. pmc Genetic control of Coxsackievirus B3-induced heart-specific autoantibodies associated with chronic myocarditis
    M D Traystman
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 6495
    Clin Exp Immunol 86:291-8. 1991
    ..Linkage could not be assigned for the anti-cardiac myosin response...
  40. ncbi A brain L-type calcium channel alpha 1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3
    H M Chin
    Laboratory of Molecular Biology, NINDS, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 11:914-9. 1991
    ..These assignments are consistent with a region of linkage homology between human chromosome 3p and a proximal region of mouse Chr 14...
  41. ncbi Rescue of a lethal purine nucleoside phosphorylase mutation in the mouse via a second locus interaction
    F F Snyder
    Department of Paediatrics, University of Calgary, Alberta, Canada
    Adv Exp Med Biol 309:133-6. 1991
  42. ncbi Genetic models of purine nucleoside phosphorylase deficiency in the mouse
    F F Snyder
    Department of Paediatrics, University of Calgary, Alberta, Canada
    Adv Exp Med Biol 309:137-40. 1991
  43. pmc Susceptibility to Coxsackievirus B3-induced chronic myocarditis maps near the murine Tcr alpha and Myhc alpha loci on chromosome 14
    M D Traystman
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198 6495
    Am J Pathol 138:721-6. 1991
    ..D2(57N) H-8b congenic mice supported this linkage relationship. Analysis of the AXB/BXA RI strain distribution patterns suggested that amd maps distal to the Np-2, Tcr alpha, and Myhc alpha loci...
  44. pmc Comparative autosomal linkage in mammals: genetics of esterases in Mus musculus and Rattus norvegicus
    J E Womack
    Genetics 82:665-75. 1976
    ..The locus was designated Esterase-10 (Es-10) and proposed as the mouse homolog of human Esterase D. Linkage of Es-10 with nucleoside phosphorylase-1-(Np-1) on Chromosome 14 was established...
  45. ncbi Genetic mapping of the gene for a novel tyrosine kinase, Blk, to mouse chromosome 14
    C A Kozak
    Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892
    Genomics 9:762-4. 1991
    ..Blk maps to the proximal region of chromosome 14 with the gene order centromere--(Np-1,Tcra)-Blk-sys-Es-10...
  46. ncbi Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14
    G Tzimagiorgis
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Crete, Greece
    Genomics 10:83-8. 1991
    ..Progeny of an intersubspecies backcross were used to map one of these genes, Glud, proximal to Np-1 on Chromosome 14, but no restriction fragment polymorphisms could be identified for the second locus, Glud-2...
  47. pmc Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis
    G R MacGregor
    Department of Cell Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030
    Proc Natl Acad Sci U S A 87:5016-20. 1990
    ..We have named the mutation "symplastic spermatids" (sys)...
  48. ncbi Localization of the gene for interphotoreceptor retinoid-binding protein to mouse chromosome 14 near Np-1
    M Danciger
    Jules Stein Eye Institute, UCLA School of Medicine 90024 1771
    Genomics 8:727-31. 1990
    ..In the human genome, NP maps to human chromosome 14 and RBP3 to human chromosome 10. Thus, these two genes span the putative site of a chromosomal translocation which contributed to divergent karyotype evolution of man and mouse...
  49. ncbi Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues
    O Miret-Duvaux
    Laboratoire de Neurophysiologie Ontogénétique, Universite Pierre et Marie Curie, Paris, France
    J Neurochem 54:23-9. 1990
    ..We conclude, for the moment, that none of these cerebellar mutant mice can be considered as an animal model for GDH-deficient MSA...
  50. ncbi A complex of serine protease genes expressed preferentially in cytotoxic T-lymphocytes is closely linked to the T-cell receptor alpha- and delta-chain genes on mouse chromosome 14
    J L Crosby
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 6:252-9. 1990
    ..Because of the involvement of serine protease loci in several homeotic mutations in Drosophila, disorganization must be considered a candidate for a mutation in a serine protease-encoding gene...
  51. ncbi Chromosomal localization of the mouse genes coding for alpha 2, alpha 3, alpha 4 and beta 2 subunits of neuronal nicotinic acetylcholine receptor
    A Bessis
    UA CNRS D1284, Departement des Biotechnologies, Institut Pasteur, Paris, France
    FEBS Lett 264:48-52. 1990
    ..14, 9 and 3 respectively. Moreover, the alpha 4 subunit gene is located on chromosome 2 but is not genetically linked to the alpha 1 subunit gene...
  52. ncbi Genetic deficiency of purine nucleoside phosphorylase in the mouse. Characterization of partially and severely enzyme deficient mutants
    E R Mably
    Department of Pediatrics, University of Calgary, Alta, Canada
    Genome 32:1026-32. 1989
    Two independent mutations of purine nucleoside phosphorylase were identified in the first-generation progeny of male mice that had been treated with the mutagen N-ethylnitrosourea and mated to untreated females...
  53. ncbi The murine retinoblastoma homolog maps to chromosome 14 near Es-10
    J C Stone
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 5:70-5. 1989
    ..Additionally, the results suggest that Es-10 is the murine homolog of ESD and provide further evidence for linkage conservation during mammalian evolution...
  54. pmc Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus
    L D Siracusa
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genetics 122:669-79. 1989
    ..The Psp-2 locus maps to mouse chromosome 14. The Hck-2 locus maps near the centromere of mouse chromosome 4 and may identify the Lyn locus. The Hck-3 locus maps near the distal end of mouse chromosome 4 and may identify the Lck locus...
  55. ncbi Cytological localization of adenosine kinase, nucleoside phosphorylase-1, and esterase-10 genes on mouse chromosome 14
    L C Samuelson
    Somat Cell Mol Genet 11:157-65. 1985
    ..The patterns of enzyme expression in these segregants were correlated with the presence of rearranged chromosomes. The Adk gene was localized to bands A2 to B, Np-1 to bands B to C1, and Es-10 to bands D2 to E2...
  56. ncbi The chromosomal location of the mouse mammary tumor gene Int6 and related pseudogenes in the mouse genome
    S Miyazaki
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, Maryland 20892, USA
    Genomics 27:420-4. 1995
    ....