Plk1

Summary

Gene Symbol: Plk1
Description: polo-like kinase 1
Alias: Plk, STPK13, serine/threonine-protein kinase PLK1, PLK-1, serine/threonine-protein kinase 13
Species: mouse

Top Publications

  1. pmc Polo-like kinase 1 is essential for early embryonic development and tumor suppression
    Lin Yu Lu
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 1520, Ann Arbor, MI 48109, USA
    Mol Cell Biol 28:6870-6. 2008
  2. pmc Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs
    Junya Ito
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Dev Biol 320:402-13. 2008
  3. ncbi Involvement of Polo-like kinase 1 in MEK1/2-regulated spindle formation during mouse oocyte meiosis
    Bo Xiong
    State Key Laboratory of Reproductive Biology, Institute of Zoology and Graduate School, Chinese Academy of Sciences, Beijing, China
    Cell Cycle 7:1804-9. 2008
  4. ncbi Polo-like kinase-1 is a pivotal regulator of microtubule assembly during mouse oocyte meiotic maturation, fertilization, and early embryonic mitosis
    Chao Tong
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Biol Reprod 67:546-54. 2002
  5. ncbi Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation
    F Wianny
    Wellcome CRC Institute and Department of Genetics, Tennis Court Road, Cambridge CB2 1QR, UK
    Chromosoma 107:430-9. 1998
  6. pmc Normal cells, but not cancer cells, survive severe Plk1 depletion
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA
    Mol Cell Biol 26:2093-108. 2006
  7. pmc Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle
    Jia Li
    From the Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York 12208
    J Biol Chem 291:23693-23703. 2016
  8. pmc sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1
    Xiaoxing Wang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Dev Cell 14:331-41. 2008
  9. pmc Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation
    Anca B Mihalas
    Department of Biological Chemistry and Solomon H Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205
    J Neurosci 33:16490-501. 2013
  10. pmc RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells
    Ryan L Ragland
    Abramson Family Cancer Research Institute, Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 27:2259-73. 2013

Scientific Experts

  • V Baran
  • Shao Chen Sun
  • Xiaoqi Liu
  • Frederic R Yarm
  • D K Ferris
  • M Yagi
  • Shilpa Tyagi
  • YUNXIA W LUNDBERG
  • T Hunter
  • K J Fowler
  • Giulia Guarguaglini
  • Paulina Wachowicz
  • Jia Li
  • Warapen Treekitkarnmongkol
  • Zhe Zhang
  • Anne C Rios
  • Ritam Chatterjee
  • Guillermo de Carcer
  • Juan Du
  • Lisa Lange
  • Petr Solc
  • Marianna Trakala
  • Sneha Ramakrishna
  • Byeong Hyeok Choi
  • Zhiguo Li
  • Alejandra Ward
  • Il Man Kim
  • Vladimir V Kalinichenko
  • Ting Yu Yeh
  • Ryan L Ragland
  • Anca B Mihalas
  • Robert H Costa
  • Sung Min Kim
  • Daisuke Sakai
  • Da Yuan Chen
  • Philip W Jordan
  • Tomohiro Izumiyama
  • Qing Yuan Sun
  • Fuyin Xiong
  • Gourish Mondal
  • Kyung Ho Lee
  • Monika Raab
  • Wei Dai
  • Asher Castiel
  • Zili He
  • Weixing Shen
  • Leo L Studach
  • Jan Motlik
  • Kazuhiro Kishi
  • Ping Zheng
  • Aiming Yu
  • Lin Yu Lu
  • Tsuyoshi Arai
  • Bo Xiong
  • Junya Ito
  • Xiaoxing Wang
  • John Pearson
  • Faical Miyara
  • I Ching Wang
  • Galina A Gusarova
  • Helena M Yoder
  • Katherine Krupczak-Hollis
  • Li Jun Huo
  • Chad J Creighton
  • Bhupinder Pal
  • Li Shen
  • Naoto T Ueno
  • Gonzalo Fernández-Miranda
  • Geoffrey J Lindeman
  • Nai Yang Fu
  • Sixin Jiang
  • Olivia J Gannon
  • Paul R Jamieson
  • Sukalpa Chattopadhyay
  • Alyssa C Rezey
  • Guoning Liao
  • Horng Ru Lin
  • Beatriz Escobar
  • Kaori Sasai
  • Kevin R Nicholas
  • Carlos Marugán
  • Lachlan Whitehead
  • Ruping Wang
  • Sujata Law
  • Hiroshi Katayama
  • Subrata Sen
  • Brennan D Gerlach
  • Jennifer Carter Jones
  • Jing Wang
  • Heng Yu Fan

Detail Information

Publications76

  1. pmc Polo-like kinase 1 is essential for early embryonic development and tumor suppression
    Lin Yu Lu
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 1520, Ann Arbor, MI 48109, USA
    Mol Cell Biol 28:6870-6. 2008
    ..Previous reports have shown that Plk1 is critical for all stages of mitosis and may play a role in DNA replication during S phase...
  2. pmc Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs
    Junya Ito
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA
    Dev Biol 320:402-13. 2008
    ..Here, we show that IP(3)R1 is a novel target for Polo-like kinase1 (Plk1), a conserved M-phase kinase, which phosphorylates it at an MPM-2 epitope...
  3. ncbi Involvement of Polo-like kinase 1 in MEK1/2-regulated spindle formation during mouse oocyte meiosis
    Bo Xiong
    State Key Laboratory of Reproductive Biology, Institute of Zoology and Graduate School, Chinese Academy of Sciences, Beijing, China
    Cell Cycle 7:1804-9. 2008
    ..In the present study, we found that Plk1 colocalized with p-MEK1/2 at various meiotic stages after GVBD when microtubule began to organize...
  4. ncbi Polo-like kinase-1 is a pivotal regulator of microtubule assembly during mouse oocyte meiotic maturation, fertilization, and early embryonic mitosis
    Chao Tong
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, People s Republic of China
    Biol Reprod 67:546-54. 2002
    ..In this experiment, the changes in Plk1 expression were detected in mouse oocytes through Western blotting...
  5. ncbi Mouse polo-like kinase 1 associates with the acentriolar spindle poles, meiotic chromosomes and spindle midzone during oocyte maturation
    F Wianny
    Wellcome CRC Institute and Department of Genetics, Tennis Court Road, Cambridge CB2 1QR, UK
    Chromosoma 107:430-9. 1998
    We have examined the dynamics of the localisation of the polo-like kinase 1 (Plk1) during maturation of the mouse oocyte...
  6. pmc Normal cells, but not cancer cells, survive severe Plk1 depletion
    Xiaoqi Liu
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA
    Mol Cell Biol 26:2093-108. 2006
    We previously reported the phenotype of depletion of polo-like kinase 1 (Plk1) using RNA interference (RNAi) and showed that p53 is stabilized in Plk1-depleted cancer cells...
  7. pmc Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle
    Jia Li
    From the Department of Molecular and Cellular Physiology, Albany Medical College, Albany, New York 12208
    J Biol Chem 291:23693-23703. 2016
    Polo-like kinase 1 (Plk1) is a serine/threonine-protein kinase that has been implicated in mitosis, cytokinesis, and smooth muscle cell proliferation. The role of Plk1 in smooth muscle contraction has not been investigated...
  8. pmc sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1
    Xiaoxing Wang
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Dev Cell 14:331-41. 2008
    ..sSgo1 interacts with Plk1 and its spindle pole localization is Plk1 dependent...
  9. pmc Opposing action of nuclear factor κB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation
    Anca B Mihalas
    Department of Biological Chemistry and Solomon H Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205
    J Neurosci 33:16490-501. 2013
    ..Chronic elevated activity, which induces Plk expression, also produces Plk-dependent activation of NF-κB...
  10. pmc RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells
    Ryan L Ragland
    Abramson Family Cancer Research Institute, Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 27:2259-73. 2013
    ..is mediated through the combined effects the sumo targeted E3-ubiquitin ligase RNF4 and activation of the AURKA-PLK1 pathway...
  11. pmc p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress
    Alejandra Ward
    Department of Biology, University of Windsor, Windsor, Ontario, Canada
    PLoS ONE 9:e87918. 2014
    ..The PLKs have been implicated in a variety of cancers, such as hepatocellular carcinoma (HCC), with PLK1 typically overexpressed and PLKs 2-5 often downregulated...
  12. pmc Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle
    Byeong Hyeok Choi
    From the Departments of Environmental Medicine, Biochemistry, and Molecular Pharmacology, New York University School of Medicine, Tuxedo, New York 10987
    J Biol Chem 289:14066-74. 2014
    ..Pulldown analysis revealed that Plk1 physically interacted with PTEN...
  13. pmc Multiple requirements of PLK1 during mouse oocyte maturation
    Petr Solc
    Institute of Animal Physiology and Genetics, Libechov, Czech Republic
    PLoS ONE 10:e0116783. 2015
    Polo-like kinase 1 (PLK1) orchestrates multiple events of cell division...
  14. doi Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice
    Marianna Trakala
    Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Blood 126:1707-14. 2015
    ..However, we show here that Polo-like kinase 1 (Plk1) is required for endomitosis, and ablation of the Plk1 gene in megakaryocytes results in defective polyploidization ..
  15. pmc Survival of primary, but not of cancer cells after combined Plk1-HDAC inhibition
    Lisa Lange
    Friedrich Schiller University, CMB, Institute for Biochemistry and Biophysics, 07745 Jena, Germany
    Oncotarget 6:25801-14. 2015
    ..Western blot and quantitative real time analyses revealed reduced Plk1 mRNA and protein in all cells...
  16. doi Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies
    Paulina Wachowicz
    Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Bioessays 38:S96-S106. 2016
    Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays multiple and essential roles during the cell division cycle. Its inhibition in cultured cells leads to severe mitotic aberrancies and cell death...
  17. pmc Unique subcellular distribution of phosphorylated Plk1 (Ser137 and Thr210) in mouse oocytes during meiotic division and pPlk1(Ser137) involvement in spindle formation and REC8 cleavage
    Juan Du
    a Department of Histology and Embryology School of Basic Medical Sciences Capital Medical University Beijing, China
    Cell Cycle 14:3566-79. 2015
    Polo-like kinase 1 (Plk1) is pivotal for proper mitotic progression, its targeting activity is regulated by precise subcellular positioning and phosphorylation...
  18. pmc Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer
    Warapen Treekitkarnmongkol
    Department of Translational Molecular Pathology
    Carcinogenesis 37:1180-1189. 2016
    ..Aurora-A overexpression in the tumor tissues accompanied activation of Akt, elevation of Cyclin D1, Tpx2 and Plk1 along with downregulation of ERα and p53 proteins, albeit at varying levels...
  19. ncbi Deregulation of vital mitotic kinase-phosphatase signaling in hematopoietic stem/progenitor compartment leads to cellular catastrophe in experimental aplastic anemia
    Ritam Chatterjee
    Stem Cell Research and Application Unit, Department of Biochemistry and Medical Biotechnology, Calcutta School of Tropical Medicine, 108, C R Avenue, Kolkata, 700073, West Bengal, India
    Mol Cell Biochem 422:121-134. 2016
    ..of some crucial mitotic and apoptotic regulators like Protein kinase-B (PKB), Gsk-3β, Cyclin-D1, PP2A, Cdc25c, Plk-1, Aurora kinase-A, Chk-1 regarding the hematopoietic catastrophe...
  20. pmc Essential role for a novel population of binucleated mammary epithelial cells in lactation
    Anne C Rios
    Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Nat Commun 7:11400. 2016
    ....
  21. pmc Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state
    Zhiguo Li
    Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA
    Mol Cell Biol 34:3642-61. 2014
    ..Increasing evidence suggests that Plk1, a cell cycle regulator, is also involved in cellular events in addition to mitosis...
  22. doi Survivin regulates Plk1 localization to kinetochore in mouse oocyte meiosis
    Shao Chen Sun
    College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    Biochem Biophys Res Commun 421:797-800. 2012
    ..b>Plk1 (polo-like kinase 1) associates with the spindle poles and also distributes to the kinetochores and is shown to ..
  23. pmc The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr
    Asher Castiel
    Sheba Cancer Research Center and Edmond and Lily Safra Children s Hospital, Sheba Medical Center, Tel Hashomer 52621, Ramat Gan, Israel
    J Cell Sci 124:532-9. 2011
    ..5 Stil(-/-) embryos, express high levels of the Chfr protein and reduced levels of the Chfr substrate Plk1. Exogenous expression of Stil, knockdown of Chfr or overexpression of Plk1 reverse the abnormal mitotic phenotypes ..
  24. doi Plk1-mediated phosphorylation of UAP56 regulates the stability of UAP56
    Fuyin Xiong
    Beijing Institute of Biotechnology, Beijing 100071, People s Republic of China
    Mol Biol Rep 39:1935-42. 2012
    Polo-like kinase 1 (Plk1) is a conserved serine/threonine protein kinase that plays pivotal roles during the cell cycle and cell proliferation...
  25. ncbi Identification of novel protein kinases expressed in the myocardium of the developing mouse heart
    J C Ruiz
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138
    Mech Dev 48:153-64. 1994
    ..75-8.5 dpc developing heart. Subsequently, msk mRNA expression is rapidly downregulated. The patterns of Hek2 and msk expression suggest that these protein kinases may function during development of the primitive heart...
  26. pmc Tex14, a Plk1-regulated protein, is required for kinetochore-microtubule attachment and regulation of the spindle assembly checkpoint
    Gourish Mondal
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Mol Cell 45:680-95. 2012
    ..that testis-expressed protein 14 (Tex14), which has been implicated in midbody function, is recruited to KTs by Plk1 in a Cdk1-dependent manner during early mitosis...
  27. pmc Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells
    Daisuke Sakai
    Stowers Institute for Medical Research, Kansas City, Missouri, United States of America
    PLoS Genet 8:e1002566. 2012
    ..We determined that Treacle elicits its effect via a direct interaction with Polo-like kinase1 (Plk1), and furthermore we discovered novel in vivo roles for Plk1 in governing mitotic progression and spindle ..
  28. pmc Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway
    Kyung Ho Lee
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    EMBO J 31:3104-17. 2012
    ..Here, we report unexpected roles of Dishevelled 2 (Dvl2) and interphase polo-like kinase 1 (Plk1) in primary cilia disassembly...
  29. doi In vivo tumor imaging using polo-box domain of polo-like kinase 1 targeted peptide
    Sung Min Kim
    Division of Magnetic Resonance Research, Korea Basic Science Institute, Ochang, Chungbuk, Republic of Korea
    Biomaterials 33:6915-25. 2012
    Polo-like kinase 1 (Plk1) is a regulator of cell cycle progression during mitosis; it is overexpressed in many different tumors and has been implicated as a potential antimitotic target...
  30. pmc Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes
    Philip W Jordan
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    J Cell Sci 125:5061-72. 2012
    ..All four PLKs are expressed during the first wave of spermatogenesis. Only PLK1 (not PLK2-4) localizes to the SC during the G2/MI transition...
  31. doi A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis
    Tomohiro Izumiyama
    Advanced Research Center for Genome Super Power, Keio University, Tsukuba, Japan
    Gene 511:202-17. 2012
    ....
  32. pmc Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit
    Ting Yu Yeh
    Department of Biology, Johns Hopkins University, Baltimore, MD, USA
    EMBO J 32:1023-35. 2013
    ..kinase 1 (Cdk1) at a single site, p27 Thr186, to generate an anchoring site for polo-like kinase 1 (Plk1) at kinetochores...
  33. ncbi Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains
    M Masuhara
    Institute of Life Science, Kurume University, Aikawamachi 2432 3, Kurume, 839 0861, Japan
    Biochem Biophys Res Commun 268:697-703. 2000
    ..These suggest that STAP-1 functions as an adaptor molecule downstream of c-kit in hematopoietic stem cells...
  34. ncbi Regulation of cAMP on the first mitotic cell cycle of mouse embryos
    Aiming Yu
    Department of Biochemical and Molecular Biology, China Medical University, Shenyang, Liaoning, China
    Mol Reprod Dev 75:489-95. 2008
    ..In the downstream of cAMP/PKA, there are some effectors such as polo-like kinase 1 (Plk1), Cdc25, Mos (mitogen-activated protein kinase kinase kinase), MEK (mitogen-activated protein kinase kinase), ..
  35. ncbi Identification of beta-catenin as a novel substrate of Polo-like kinase 1
    Tsuyoshi Arai
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Tsukuba, Ibaraki, Japan
    Cell Cycle 7:3556-63. 2008
    Polo-like kinase 1 (Plk1) is a serine/threonine kinase that plays an important role in M phase progression by regulating various downstream substrates via phosphorylation...
  36. pmc Functional dynamics of Polo-like kinase 1 at the centrosome
    Kazuhiro Kishi
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell Biol 29:3134-50. 2009
    Polo-like kinase 1 (Plk1) functions as a key regulator of mitotic events by phosphorylating substrate proteins on centrosomes, kinetochores, the mitotic spindle, and the midbody...
  37. pmc Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis
    Ping Zheng
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:7473-8. 2009
    ..e., AURKA, PLK1, and gamma-tubulin) to the microtubule-organizing center via the RhoA signaling pathway...
  38. pmc Polo-like kinase 1 inhibition suppresses hepatitis B virus X protein-induced transformation in an in vitro model of liver cancer progression
    Leo L Studach
    Department of Basic Medical Sciences, Purdue University, West Lafayette, IN 47907 2026, USA
    Hepatology 50:414-23. 2009
    ..One of these genes is the mitotic kinase Polo-like kinase 1 (Plk1). Oncogenic transformation is suppressed in the absence of pX expression, and significantly, by inhibition of Plk1...
  39. doi Polo-like kinase1 (Plk1) knockdown enhances cisplatin chemosensitivity via up-regulation of p73α in p53 mutant human epidermoid squamous carcinoma cells
    Shilpa Tyagi
    Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, Mahatma Gandhi Marg, Lucknow, U P, India
    Biochem Pharmacol 80:1326-34. 2010
    Polo-like kinase 1 (Plk1), a critical regulator of mitotic entry, progression and exit, has been shown to be involved in a variety of cancers and thus is becoming an attractive target for cancer management...
  40. pmc Female infertility in PDE3A(-/-) mice: polo-like kinase 1 (Plk1) may be a target of protein kinase A (PKA) and involved in meiotic arrest of oocytes from PDE3A(-/-) mice
    Weixing Shen
    Translational Medicine Branch TMB, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA
    Cell Cycle 9:4720-34. 2010
    ..G2/M-arrested PDE3A(-/-) murine oocytes, elevated PKA activity was associated with inactivation of Cdc2 and Plk1, and inhibition of phosphorylation of histone H3 (S10) and of dephosphorylation of Cdc25B (S323) and Cdc2 (Thr14/..
  41. doi Polo-like kinase 1 contributes to the tumorigenicity of BEL-7402 hepatoma cells via regulation of Survivin expression
    Zili He
    Department of Hepatobiliary Surgery, Hunan Provincial People s Hospital, Hunan, China
    Cancer Lett 303:92-8. 2011
    Polo-like kinase 1 (PLK1) is required for multiple stages of mitosis and has been found to be overexpressed in many human malignancies...
  42. pmc Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells
    Monika Raab
    Department of Obstetrics and Gynecology, School of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Nat Commun 2:395. 2011
    ..Although polo-like kinase 1 (Plk1) inhibitors are attractive candidates for drug development, the role of Plk1 in primary cells remains widely ..
  43. pmc Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formation
    X Shawn Liu
    Department of Biochemistry, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 286:35795-800. 2011
    ..Further, depletion of Pten results in elevated expression of Polo-like kinase 1 (Plk1), a critical regulator of the cell cycle...
  44. ncbi Cloning and chromosomal localization of a new member of the bHLH/PAS transcription factor family
    C D Wolting
    Amgen Research Institute, Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, 620 University Ave, Suite 706, Toronto, Ontario, Canada, M5G 2C1
    Mamm Genome 9:463-8. 1998
    ..Interspecies backcross and FISH mapping have been used to localize the Tic gene to mouse Chromosome (Chr) 7 F2-F3, given the locus name Arntl. FISH mapping was also used to localize the human gene to Chr 11p15...
  45. ncbi Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5
    G Glowacki
    Institute for Immunology, University Hospital, Martinistrasse 52, 20246 Hamburg, Germany
    Gene 275:267-77. 2001
    ..The secreted epitope-tagged ART5 protein resembled rat ART2 in exhibiting potent NAD-glycohydrolase activity. This study provides important experimental tools to further elucidate the function of ART5...
  46. ncbi The mouse Psma1 gene coding for the alpha-type C2 proteasome subunit: structural and functional analysis, mapping, and colocalization with Pde3b on mouse chromosome 7
    A Hopitzan
    Research and Development, Boehringer Ingelheim Austria, Vienna, 1121, Austria
    Genomics 66:313-23. 2000
    ..3 in a region syntenic to human chromosome 11p15. Our results extend the structural and functional analysis of genes encoding the 20S proteasome subunits and provide the basis for the study of their regulation...
  47. ncbi Expression of polo-like kinase (PLK) in the mouse placenta and ovary
    N Takai
    Department of Obstetrics and Gynecology, Oita Medical University, Japan
    Reprod Fertil Dev 11:31-5. 1999
    The polo-like kinase (PLK) is a mammalian serine/threonine kinase involved in cell cycle regulation...
  48. ncbi Mouse mitotic spindle checkpoint Bub3 gene maps to the distal region of chromosome 7 by interspecific backcross analysis
    K J Fowler
    The Murdoch Institute, Royal Children s Hospital, Parkville, Victoria, Australia
    Cytogenet Cell Genet 87:91-2. 1999
  49. ncbi Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain
    K Nelms
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 10:1160-7. 1999
    ..Additionally, the chromosomal location of the SH2-B gene was determined to be the distal arm of mouse Chromosome (Chr) 7 in a region linked to obesity in mice...
  50. ncbi PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments
    S Xu
    Predoctoral Training Program in Human Genetics, Department of Pediatrics, Baltimore, Maryland 21205, USA
    J Biol Chem 274:35676-85. 1999
    ..This activity and subcellular location suggests that PHR1 may function as a previously unrecognized modulator of the phototransduction pathway...
  51. ncbi Ubiquitination and proteasome mediated degradation of polo-like kinase
    D K Ferris
    Intramural Research Support Program, SAIC Frederick, Frederick, Maryland, 21702 1201, USA
    Biochem Biophys Res Commun 252:340-4. 1998
    Polo-like kinase (Plk) is a cell cycle-regulated, cyclin-independent serine/threonine protein kinase...
  52. pmc Cloning of mammalian Ire1 reveals diversity in the ER stress responses
    X Z Wang
    Skirball Institute of Biomolecular Medicine, the Departments of Medicine, Cell Biology and the Kaplan Cancer Center, NYU Medical Center, New York, NY 10016, USA
    EMBO J 17:5708-17. 1998
    ..These results indicate that a single upstream component, Ire1, plays a role in multiple facets of the ER stress-response in mammalian cells...
  53. ncbi Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice
    J Tay
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655, USA
    Dev Cell 1:201-13. 2001
    ..Synaptonemal complexes were not detected in these animals. CPEB therefore controls germ cell differentiation by regulating the formation of the synaptonemal complex...
  54. ncbi The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells
    R Y Poon
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong
    Cancer Res 57:5168-78. 1997
    ..Thus, the decrease in Cdc25C activity may in part account for the DNA damage-induced increase in Thr14/Tyr15 phosphorylation...
  55. ncbi The mouse Plk gene: structural characterization, chromosomal localization and identification of a processed Plk pseudogene
    F J Clay
    Ludwig Institute for Cancer Research, Melbourne Branch, Royal Melbourne Hospital, Victoria, Australia
    Gene 198:329-39. 1997
    ..Based on homology with the human PLK1 promoter region, the putative mouse promoter region includes a CCAAT motif but lacks the conventional TATA motif...
  56. pmc Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1
    K S Lee
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 15:7143-51. 1995
    PLK (STPK13) encodes a murine protein kinase closely related to those encoded by the Drosophila melanogaster polo gene and the Saccharomyces cerevisiae CDC5 gene, which are required for normal mitotic and meiotic divisions...
  57. pmc Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila
    F J Clay
    Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, PO Royal Melbourne Hospital, Victoria, Australia
    Proc Natl Acad Sci U S A 90:4882-6. 1993
    ..is closely related to the enzyme encoded by the Drosophila melanogaster mutant polo and that we have designated Plk (polo-like kinase)...
  58. ncbi Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase
    R Hamanaka
    Laboratory of Leukocyte Biology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702
    Cell Growth Differ 5:249-57. 1994
    ..are homologous to the Drosophila serine/threonine polo kinase and the recently cloned murine polo related kinase (PLK). Both the human and murine clones are about 2.1 kilobases with open reading frames of 1...
  59. pmc Cell cycle- and terminal differentiation-associated regulation of the mouse mRNA encoding a conserved mitotic protein kinase
    R J Lake
    Department of Biochemistry, New York University Medical Center, New York 10016
    Mol Cell Biol 13:7793-801. 1993
    We determined the nucleotide sequence of a mouse and a human cDNA, which we designate STPK13, that encodes an apparent protein kinase related to that encoded by the Drosophila melanogaster polo gene and the Saccharomyces cerevisiae CDC5 ..
  60. ncbi Murine polo like kinase 1 gene is expressed in meiotic testicular germ cells and oocytes
    N Matsubara
    Department of Cell Biology, Tohoku University, Sendai, Japan
    Mol Reprod Dev 41:407-15. 1995
    ..of the entire coding regions shows that this clone, designated Plk1(polo like kinase 1), is identical with STPK13 previously cloned from murine erythro-leukemia cells...
  61. ncbi Identification and functional characterization of the human and murine polo-like kinase (Plk) promoter
    A Bräuninger
    Chemotherapeutisches Forschungsinstitut Georg Speyer Haus, Frankfurt, Germany
    Oncogene 11:1793-800. 1995
    The Plk gene encodes a serine/theronine kinase which is located in the nucleus. Northern blot analysis linked Plk expression to the proliferative activity of cells and tissues...
  62. pmc Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
    Young Joo Jang
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 99:1984-9. 2002
    Mammalian polo-like kinase (Plk) acts at various stages in early and late mitosis. Plk is phosphorylated and activated in mitosis, and the proper subcellular localization of Plk is essential for mitotic regulation...
  63. pmc Plk phosphorylation regulates the microtubule-stabilizing protein TCTP
    Frederic R Yarm
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 22:6209-21. 2002
    ..and -stabilizing protein, the translationally controlled tumor protein (TCTP), was identified as a putative Plk-interacting clone by a two-hybrid screen...
  64. ncbi The murine macrophage apoB-48 receptor gene (Apob-48r): homology to the human receptor
    Matthew L Brown
    Department of Medicine, Division of Gerontology and Geriatrics, University of Alabama at Birmingham, Birmingham, AL 35294 0012, USA
    J Lipid Res 43:1181-91. 2002
    ....
  65. ncbi Cell cycle dependent expression of Plk1 in synchronized porcine fetal fibroblasts
    Martin Anger
    Institute of Animal Physiology and Genetics, Libechov, Czech Republic
    Mol Reprod Dev 65:245-53. 2003
    ..We have cloned cDNA fragments of the porcine homologues of Plk1, Plk2, and Plk3 employing fetal fibroblasts as source...
  66. ncbi M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex
    Horng Ru Lin
    Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, San Antonio, Texas 78245, USA
    J Biol Chem 278:35979-87. 2003
    ..analysis identified two phosphopeptides that contain "phosphorylation consensus motifs" for Polo-like kinase 1 (Plk1)...
  67. ncbi Mapping a chromosomal locus for valproic acid-induced exencephaly in mice
    Yunxia Wang Lundberg
    Genetics Department, Boys Town National Research Hospital, Omaha, Nebraska 68131, USA
    Mamm Genome 15:361-9. 2004
    ..These results suggest a major chromosomal locus associated with the sensitivity to VPA-induced exencephaly in mice...
  68. ncbi Ubiquitin-proteasome pathway modulates mouse oocyte meiotic maturation and fertilization via regulation of MAPK cascade and cyclin B1 degradation
    Li Jun Huo
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Graduate School of the Chinese Academy of Sciences, Beijing 100080, China
    Mech Dev 121:1275-87. 2004
    ..metaphase I spindle assembly was prevented, and the distribution of ubiquitin, cyclin B1, and polo-like kinase 1 (Plk1) was also distorted...
  69. ncbi The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis
    Katherine Krupczak-Hollis
    Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL 60607 7170, USA
    Dev Biol 276:74-88. 2004
    ....
  70. pmc The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles
    Giulia Guarguaglini
    Department of Cell Biology, Max Planck Institute for Biochemistry, D 82152, Martinsried, Germany
    Mol Biol Cell 16:1095-107. 2005
    ..Cep170 was identified in a yeast two-hybrid screen for interactors of Polo-like kinase 1 (Plk1). In human cells, Cep170 is constantly expressed throughout the cell cycle but phosphorylated during mitosis...
  71. ncbi The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature
    Il Man Kim
    Department of Medicine and Committee on Developmental Biology, The University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 280:22278-86. 2005
    ..In summary, development of mouse lungs depends on the Foxm1 transcription factor, which regulates expression of genes essential for mesenchyme proliferation, extracellular matrix remodeling, and vasculogenesis...
  72. ncbi Non-equivalence of embryonic and somatic cell nuclei affecting spindle composition in clones
    Faical Miyara
    The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Dev Biol 289:206-17. 2006
    ..These results reveal a striking control of SCC formation by the transplanted nucleus and provide the first identified molecular correlate of donor stage-dependent restriction in nuclear potency...
  73. ncbi Heterologous expression of mammalian Plk1 in Drosophila reveals divergence from Polo during late mitosis
    John Pearson
    Cancer Research UK Cell Cycle Genetics Research Group, University of Cambridge, Department of Genetics, Downing Street, Cambridge CB2 3EH, UK
    Exp Cell Res 312:770-81. 2006
    ..We assessed the ability of mouse Polo-like kinase 1 (Plk1) to perform the multiple mitotic functions of Polo kinase, by expressing a Plk1-GFP fusion in Drosophila...
  74. ncbi Megakaryocyte polyploidization is associated with decreased expression of polo-like kinase (PLK)
    M Yagi
    Research, Seattle Division, Veterans Affairs Puget Sound Health Care System, WA 98108, USA
    J Thromb Haemost 4:2028-34. 2006
    ..Therefore, understanding the molecular mechanisms regulating polyploidization could identify events involved in controlling both cell division and thrombopoiesis...
  75. ncbi Polo-like kinase 1 may regulate G2/M transition of mouse fertilized eggs by means of inhibiting the phosphorylation of Tyr 15 of Cdc2
    Zhe Zhang
    Department of Biochemical and Molecular Biology, China Medical University, Shenyang, Liaoning, China
    Mol Reprod Dev 74:1247-54. 2007
    Polo-like kinase 1(Plk1) has been reported to be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during mammalian early embryonic mitosis...
  76. ncbi Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor
    Sneha Ramakrishna
    Department of Medicine, University of Chicago, Chicago, Illinois
    Dev Dyn 236:1000-13. 2007
    ..Foxm1 regulates expression of genes essential for the proliferation of cardiomyocytes during heart development...