Plcg1

Summary

Gene Symbol: Plcg1
Description: phospholipase C, gamma 1
Alias: AI894140, Cded, Plc-1, Plc-gamma1, Plcg-1, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, PLC-gamma-1, cell differentiation and embryonic development, phosphoinositide phospholipase C-gamma-1
Species: mouse

Top Publications

  1. pmc Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading
    Esteban Carrizosa
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 183:7352-61. 2009
  2. pmc Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1
    Yutaka Harita
    Division of Cellular Proteomics BML and Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 284:8951-62. 2009
  3. doi Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression
    Qin Wang
    Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada, M5S 3E2
    Biochem J 449:771-82. 2013
  4. pmc A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice
    Robert L Kortum
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:147-58. 2013
  5. ncbi Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity
    Jong Soo Chang
    Department of Life Science, College of Natural Science, Daejin University, Kyeonggido 487 711, Korea
    J Biol Chem 277:19697-702. 2002
  6. ncbi The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase
    Christine Tkaczyk
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:48474-84. 2003
  7. ncbi Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation
    Fujio Sekiya
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:32181-90. 2004
  8. pmc Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses
    Sara Gorjestani
    Department of Molecular and Cellular Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 286:43651-9. 2011
  9. ncbi Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
    K Bachmaier
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 403:211-6. 2000
  10. ncbi Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice
    Hong Jun Liao
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:9335-41. 2002

Scientific Experts

  • Xiaoming Zhou
  • Yong Xiao Wang
  • Jong Soo Chang
  • Tianqing Peng
  • LAWRENCE KANE
  • M R Smith
  • C M Williamson
  • S L Godwin
  • Jin Ming Yang
  • Natarajan Muthusamy
  • Claudio Sette
  • Madhu Khullar
  • Jonathan A Cooper
  • Amnon Altman
  • Elena Vigorito
  • Charles R Farber
  • Demin Wang
  • Renren Wen
  • WILLIAM ARTHUR
  • Guoping Fu
  • Yuhong Chen
  • Liliana Minichiello
  • Carla Sciarretta
  • Qin Wang
  • Sung Ho Ryu
  • Pann Ghill Suh
  • Jang Hyun Choi
  • Yong Ryoul Yang
  • Weiguo Zhang
  • James Schuman
  • Denis Tvorogov
  • Du Seock Kang
  • Graham Carpenter
  • Sarah A Sullivan
  • Xiaohua Peng
  • Yun Soo Bae
  • Luis Alberto Pérez-Quintero
  • Connie L Sommers
  • Cong Cao
  • Vishal R Yadav
  • Joshua Jamison
  • Robert L Kortum
  • Di Wang
  • Yasushi Ishijima
  • Minghua Zhu
  • Roberta Fiume
  • Sara Gorjestani
  • R D Meyer
  • Yonghao Cao
  • Mei Yu
  • Eunok Im
  • Carlos E Irarrazabal
  • Yu Peng Liu
  • Xiao Ping He
  • Laura A Shannon
  • Mariana I Chuck
  • Anne Moenning
  • Guo Fu
  • Nicholas G Clarkson
  • Yutaka Harita
  • Hirotake Ichise
  • Hitoshi Sase
  • Nodi Dehvari
  • Q S Ji
  • Cornelia E Crooke
  • Esteban Carrizosa
  • Soo Hyun Yoon
  • Gregory P Downey
  • Mira M Wouters
  • Christopher A McCulloch
  • Ya li Li
  • Holly Epple
  • Lawrence E Samelson
  • Tohru Tezuka
  • Yan Li
  • Ryosuke Usui
  • Alagarsamy Lakku Reddi
  • E Shen
  • Tomi Rantamäki
  • Annette Gärtner
  • Keylon L Cheeseman
  • Takanobu Nakazawa
  • Jeyarani Regunathan
  • Maria H Johansson
  • T Montoye
  • Jong Ik Hwang
  • Min Hee Choi
  • Adrienne Halupa
  • Neil P Jones
  • Dwayne L Barber

Detail Information

Publications108 found, 100 shown here

  1. pmc Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading
    Esteban Carrizosa
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Immunol 183:7352-61. 2009
    ..We conclude that HS1 functions as an effector of Itk in the T cell actin-regulatory pathway, and directs the spatial organization of PLCgamma1 signaling complexes...
  2. pmc Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1
    Yutaka Harita
    Division of Cellular Proteomics BML and Department of Oncology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 284:8951-62. 2009
    ..Given the profound effect of PLC-gamma in diverse cellular functions, regulation of the Ca(2+) signaling by Nephrin may be important in modulating the glomerular filtration barrier function...
  3. doi Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression
    Qin Wang
    Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada, M5S 3E2
    Biochem J 449:771-82. 2013
    ....
  4. pmc A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice
    Robert L Kortum
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 190:147-58. 2013
    ..Moreover, LAT-Y136F T cells showed ERK activation that was dependent on Lck and/or Fyn, protein kinase C-θ, and RasGRP1. These data demonstrate a novel route to Ras activation in vivo in a pathological setting...
  5. ncbi Interaction of elongation factor-1alpha and pleckstrin homology domain of phospholipase C-gamma 1 with activating its activity
    Jong Soo Chang
    Department of Life Science, College of Natural Science, Daejin University, Kyeonggido 487 711, Korea
    J Biol Chem 277:19697-702. 2002
    ..Taken together, our data show that EF-1alpha plays a direct role in phosphoinositide metabolism of cellular signaling by regulating PLC-gamma1 activity via a split PH domain...
  6. ncbi The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase
    Christine Tkaczyk
    Laboratory of Allergic Diseases, National Institute of Allergy and Infectious National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:48474-84. 2003
    ..Here we report evidence that the PLC gamma 1-dependent pathway of Fc epsilon RI-mediated activation of mast cells is independent of PI 3-kinase activation...
  7. ncbi Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation
    Fujio Sekiya
    Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:32181-90. 2004
    ..Finally, concurrent production of phosphatidylinositol 3,4,5-trisphosphate was found to contribute to the activation of phosphorylated PLC-gamma 1...
  8. pmc Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses
    Sara Gorjestani
    Department of Molecular and Cellular Oncology, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 286:43651-9. 2011
    ..albicans infection in vivo. Together, these findings demonstrate that PLCγ2 plays a critical role in CLR-induced signaling pathways, governing antifungal innate immune responses...
  9. ncbi Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
    K Bachmaier
    Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Nature 403:211-6. 2000
    ..Cbl-b is thus a key regulator of activation thresholds in mature lymphocytes and immunological tolerance and autoimmunity...
  10. ncbi Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice
    Hong Jun Liao
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Biol Chem 277:9335-41. 2002
    Mice nullizygous for Plcg1 cease growing at early to mid-gestation...
  11. ncbi A LAT mutation that inhibits T cell development yet induces lymphoproliferation
    Connie L Sommers
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 296:2040-3. 2002
    ..In contrast, TCR-induced Erk activation was intact. These results identify a critical role for integrated PLC-gamma1 and Ras-Erk signaling through LAT in T cell development and homeostasis...
  12. ncbi Mechanism of TrkB-mediated hippocampal long-term potentiation
    Liliana Minichiello
    European Molecular Biology Laboratory, Via Ramarini 32, 00016, Monterotondo, Italy
    Neuron 36:121-37. 2002
    ..Our results provide genetic evidence that TrkB mediates hippocampal plasticity via recruitment of PLCgamma, and by subsequent phosphorylation of CaMKIV and CREB...
  13. pmc An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion
    Renren Wen
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    EMBO J 23:4007-17. 2004
    ..These studies reveal an essential role of PLCgamma1, distinct from that of PLCgamma2, in B-cell development...
  14. ncbi Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling
    Annette Gärtner
    Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    J Neurosci 26:3496-504. 2006
    ..Blockade of presynaptic or postsynaptic signaling alone did not result in a significant reduction of LTP...
  15. ncbi Differential and nonredundant roles of phospholipase Cgamma2 and phospholipase Cgamma1 in the terminal maturation of NK cells
    Jeyarani Regunathan
    Blood Research Institute, Milwaukee, WI 53226, USA
    J Immunol 177:5365-76. 2006
    ..Our results strongly demonstrate that PLCgamma1 and PLCgamma2 play nonredundant and obligatory roles in NK cell ontogeny and in its effector functions...
  16. ncbi Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation
    Alagarsamy Lakku Reddi
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:29336-47. 2007
    ....
  17. pmc Inhibition and activation by CD244 depends on CD2 and phospholipase C-gamma1
    Nicholas G Clarkson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Biol Chem 284:24725-34. 2009
    ..We identify a novel signaling mechanism for CD244 through its potential to recruit phospholipase C-gamma1 via the conserved phosphorylated tyrosine motif in the tail of the adaptor protein EAT-2, which we show is important for function...
  18. pmc Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance
    Guoping Fu
    The Blood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA
    J Exp Med 207:309-18. 2010
    ..Importantly, PLCgamma1 deficiency impairs the development and function of FoxP3(+) regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLCgamma1 is essential for T cell development, activation, and tolerance...
  19. pmc Phospholipase Cγ2 plays a role in TCR signal transduction and T cell selection
    Guoping Fu
    Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 189:2326-32. 2012
    ..Taken together, these data demonstrate that PLCγ2 participates in TCR signal transduction and plays a role in T cell selection...
  20. pmc Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development
    Q S Ji
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 94:2999-3003. 1997
    ..examine the biological function of this protein, homologous recombination has been used to selectively disrupt the Plcg1 gene in mice. Homozygous disruption of Plcg1 results in embryonic lethality at approximately embryonic day (E) 9.0...
  21. pmc Epidermal growth factor signaling and mitogenesis in Plcg1 null mouse embryonic fibroblasts
    Q S Ji
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    Mol Biol Cell 9:749-57. 1998
    ..b>Plcg1(-/-) embryos die at embryonic day 9; however, cells derived from these embryos proliferate as well as cells from ..
  22. ncbi Association of p72syk with the src homology-2 (SH2) domains of PLC gamma 1 in B lymphocytes
    A L Sillman
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Biol Chem 270:11806-11. 1995
    ..We have used a fusion protein containing the tandem src homology-2 (SH2) domains of phospholipase C gamma 1 (PLC gamma 1) to identify B cell kinases which associate with PLC gamma 1...
  23. pmc The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor
    R Rottapel
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Cell Biol 11:3043-51. 1991
    ..These results suggest that Kit autophosphorylation and its physical association with a unique subset of cytoplasmic signaling proteins are critical for mammalian development...
  24. ncbi Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1
    K Yoshida
    Division of Functional Genomics, Departments of Hematology and Cardiology, Jichi Medical School, Kawachi gun, Tochigi 329 0498, Japan
    J Biol Chem 275:24945-52. 2000
    ..Furthermore, overexpression of Dok-1 inhibited activation of the c-fos promoter induced by stimulation of the BCR. These results suggest that Tec is an important mediator of signaling from the BCR to Dok-1...
  25. ncbi PLC-gamma1 is required for IGF-I protection from cell death induced by loss of extracellular matrix adhesion
    Ansuman Chattopadhyay
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Cell Sci 115:2233-9. 2002
    ..Spontaneously immortalized mouse embryonic fibroblasts nullizygous at the Plcg1 locus (Plcg1(-/-)), referred to as Null cells, were derived from targeted gene disruption experiments...
  26. ncbi Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Biol 14:606-10. 2004
    ..C3G and Rap1 regulate adhesion of fibroblasts and other cell types. Regulation of Crk/CrkL, C3G, and Rap1 by Reelin may be involved in coordinating neuron migrations during brain development...
  27. ncbi SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
    Qin Wang
    Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E8
    J Biol Chem 280:8397-406. 2005
    ..Focal adhesions co-localizing with the endoplasmic reticulum may provide molecular staging sites required for ERK activation...
  28. ncbi Analysis of leptin signalling in hematopoietic cells using an adapted MAPPIT strategy
    T Montoye
    Flanders Interuniversity Institute for Biotechnology, Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, A Baertsoenkaai 3, B 9000 Ghent, Belgium
    FEBS Lett 580:3301-7. 2006
    ..We also provide evidence for novel interactions at the Y1077 motif, including phospholipase C gamma and several members of the SOCS protein family, further underscoring the important role of the Y1077 motif in leptin signalling...
  29. pmc Ligand-independent activation of vascular endothelial growth factor receptor 1 by low-density lipoprotein
    Ryosuke Usui
    Department of Pharmacology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    EMBO Rep 8:1155-61. 2007
    ..We propose that LDLR-mediated use of VEGFR1 by nLDL could be a potential therapeutic target in atherosclerotic disorders...
  30. pmc Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis
    Xiao Ping He
    Department of Medicine Neurology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 30:6188-96. 2010
    ..Elucidating signaling pathways activated by a cell membrane receptor in animal models of CNS disorders promises to reveal novel targets for specific and effective therapeutic intervention...
  31. pmc LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection
    Yonghao Cao
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    EMBO J 30:2083-93. 2011
    ..These observations indicated that LKB1 is a critical component involved in TCR signalling, and our studies provide novel insights into the mechanisms of LKB1-mediated thymocyte development...
  32. doi Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling
    Di Wang
    Institute of Immunology, Zhejiang University School of Medicine, Hangzhou, China
    Nat Immunol 13:560-8. 2012
    ..Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development...
  33. pmc PKCδ localization at the membrane increases matrix traction force dependent on PLCγ1/EGFR signaling
    Joshua Jamison
    Department of Pathology, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 8:e77434. 2013
    ..Therefore, we investigated whether the membrane localization of PKCδ mediates the transcellular contractility of fibroblasts...
  34. pmc The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis
    Sarah A Sullivan
    Department of Immunology, Duke University Medical Center, Durham, NC 27710
    J Immunol 192:2865-74. 2014
    ..Our data indicated that a unique subset of CD4 γδ T cells can hyperproliferate in LATY136F mice and suggested that LAT-PLCγ1 signaling may function differently in various subsets of γδ T cells. ..
  35. pmc EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization
    Luis Alberto Pérez-Quintero
    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    J Exp Med 211:727-42. 2014
    ..Hence, EAT-2 promotes NK cell activation by molecular and cellular mechanisms distinct from those of SAP. These findings explain the cooperative and essential function of these two adaptors in NK cell activation. ..
  36. doi Low level of LAT-PLC-γ1 interaction is associated with Th2 polarized differentiation: a contributing factor to the etiology of asthma
    Xiaohua Peng
    Department of Respiratory Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
    Cell Immunol 290:131-7. 2014
    ..It was therefore concluded that the low level of LAT-PLC-γ1 interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma...
  37. doi Roles of phosphoinositide-specific phospholipase Cγ1 in brain development
    Du Seock Kang
    School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan 689 798, Republic of Korea
    Adv Biol Regul 60:167-73. 2016
    ....
  38. pmc Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylation
    Keun Il Kim
    The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Cell Biol 24:9592-600. 2004
    ..This method provides an easy and effective way to identify new targets for the ISGylation system and will facilitate related studies...
  39. doi Nuclear PLCs affect insulin secretion by targeting PPARγ in pancreatic β cells
    Roberta Fiume
    Department of Human Anatomy, University of Bologna, Bologna, Italy
    FASEB J 26:203-10. 2012
    ..These findings highlight a novel pathway by which nuclear PLCs affect insulin secretion and identify PPARγ as a novel molecular target of nuclear PLCs...
  40. doi GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-γ1
    Yasushi Ishijima
    Faculty of Pharmacy, Department of Pharmacy, Takasaki University of Health and Welfare, 60 Nakaorui machi, Takasaki, Gunma 370 0033, Japan
    Genes Cells 17:285-301. 2012
    ..These data indicate that PLC-γ1 is a target gene of GATA factors in mast cells and provide evidence that GATA1 and GATA2 control antigen-mediated mast cell degranulation by regulating the expression of PLC-γ1...
  41. pmc Important role of PLC-γ1 in hypoxic increase in intracellular calcium in pulmonary arterial smooth muscle cells
    Vishal R Yadav
    Center for Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA
    Am J Physiol Lung Cell Mol Physiol 304:L143-51. 2013
    ....
  42. pmc Impairment of TrkB-PSD-95 signaling in Angelman syndrome
    Cong Cao
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island, United States of America
    PLoS Biol 11:e1001478. 2013
    ..We propose that the failure of TrkB receptor signaling at synapses in AS is directly linked to elevated levels of Arc associated with PSD-95 and PSD-95 PDZ-ligands may represent a promising approach to reverse cognitive dysfunction...
  43. pmc High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains
    B Margolis
    Department of Pharmacology, New York University Medical Center, NY 10016
    Proc Natl Acad Sci U S A 89:8894-8. 1992
    ..Use of this expression/cloning system should increase our ability to identify downstream modulators of growth factor action...
  44. ncbi Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
    D D Schlaepfer
    Molecular Biology and Virology Laboratory, Salk Institute, San Diego, California 92186
    Nature 372:786-91. 1994
    ..Phosphorylation of FAK at Tyr 925 upon fibronectin stimulation creates an SH2-binding site for GRB2 which may link integrin engagement to the activation of the Ras/MAPK signal transduction pathway...
  45. pmc Phospholipase C in mouse oocytes: characterization of beta and gamma isoforms and their possible involvement in sperm-induced Ca2+ spiking
    G Dupont
    Babraham Institute for Molecular Signalling, Department of Zoology, University of Cambridge, U K
    Biochem J 316:583-91. 1996
    ..Furthermore, immunodetection of PLC gamma 1 using monoclonal antibodies reveals that PLC gamma 1 protein is present in mature mouse oocytes, ruling out the ..
  46. ncbi Overexpression of phosphoinositide-specific phospholipase Cgamma in NIH 3T3 cells promotes transformation and tumorigenicity
    M R Smith
    Intramural Research Support Program, SAIC Frederick, Laboratory of Biochemical Physiology, National Cancer Institute, Frederick Cancer Research and Development Center, MD 21702, USA
    Carcinogenesis 19:177-85. 1998
    ..Furthermore, PLCgamma expression and activity have been shown to be elevated in many human tumors. Thus, PLCgamma signaling may contribute to the promotion and/or progression of human cancers...
  47. ncbi Phospholipase C-gamma, protein kinase C and Ca2+/calmodulin-dependent protein kinase II are involved in platelet-derived growth factor-induced phosphorylation of Tiam1
    I N Fleming
    Howard Hughes Medical Institute and Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    FEBS Lett 429:229-33. 1998
    ..Moreover, PDGF-stimulated Tiam1 phosphorylation was markedly reduced by 72 +/- 10% in PLC-gamma1 deficient mouse fibroblasts, compared to wild-type cells, indicating that phosphoinositide phospholipase C is involved...
  48. ncbi Analysis of platelet-derived growth factor-induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C-gamma1
    J A Hess
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0295, USA
    J Biol Chem 273:20517-24. 1998
    ..In order to investigate a role for phospholipase C-gamma1 (PLC-gamma1), we used targeted disruption of the Plcg1 gene in the mouse to develop Plcg1(+/+) and Plcg1(-/-) cell lines...
  49. ncbi Genomic structure, chromosomal mapping, and muscle-specific expression of a PH domain-associated intronless gene, cded/lior
    L Mishra
    Laboratory of Developmental Molecular Biology, Department of Veterans Affairs, 151 W, 50 Irving Street NW, Washington, DC 20422, USA
    Mamm Genome 10:62-7. 1999
    ..Mouse cded/lior was identified from subtraction hybridization of embryonic liver cDNA libraries as well as an adult mouse ..
  50. ncbi Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22
    J Yohannan
    Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 274:18769-76. 1999
    ..This finding suggests that PLCgamma and PI3K may be recruited to CD22 either through a direct interaction with Tyr863 or indirectly through an association with one or more intermediate proteins...
  51. pmc Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation
    J Grimm
    Max Delbrueck Center for Molecular Medicine, 13092 Berlin, Germany
    J Cell Biol 154:345-54. 2001
    ..Thus, we have identified a subclass of p62dok proteins that are putative links with downstream effectors of c-Ret in neuronal differentiation...
  52. ncbi Activation of phospholipase C induces the expression of the multidrug resistance (MDR1) gene through the Raf-MAPK pathway
    J M Yang
    The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA
    Mol Pharmacol 60:674-80. 2001
    ....
  53. ncbi Deficiency of phospholipase C-gamma1 impairs renal development and hematopoiesis
    M Shirane
    Department of Product Research and Department of Molecular Oncology, Nippon Roche Research Center, Kajiwara 200, Kamakura, Kanagawa 247 8530, Japan
    Development 128:5173-80. 2001
    ..These data suggest that PLC-gamma1 plays an essential role in the renal development and hematopoiesis in vivo...
  54. ncbi Macrophage/microglia-specific protein Iba1 enhances membrane ruffling and Rac activation via phospholipase C-gamma -dependent pathway
    Hiroko Kanazawa
    Department of Neurochemistry, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biol Chem 277:20026-32. 2002
    ..These results indicate the existence of a novel signaling pathway where PLC-gamma activates Rac in a manner dependent on Iba1...
  55. ncbi Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts
    S L Godwin
    Department of Orthodontics, University of Connecticut Health Center, Farmington, CT 06030, USA
    Bone 30:559-66. 2002
    ....
  56. ncbi EGF-dependent association of phospholipase C-gamma1 with c-Cbl
    Denis Tvorogov
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Exp Cell Res 277:86-94. 2002
    ..in the context of the full-length PLC-gamma1, this domain was deleted and the mutant was stably expressed in Plcg1 null mouse embryonic fibroblasts...
  57. ncbi Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect
    Stephane Maddens
    Institut Nationale de la Santé et de la Recherche Médicale E9910, Institut Claudius Regaud, Toulouse, France
    Blood 100:1294-301. 2002
    ..Moreover, SCF did not protect 32D-KitYF728 cells (lacking a functional docking site for PLC gamma 1), from IR-induced SM cycle...
  58. pmc Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase
    Claudio Sette
    Department of Public Health and Cell Biology, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy
    EMBO J 21:5386-95. 2002
    ..We suggest that the mechanism by which tr-kit triggers resumption of meiosis of mouse eggs requires a functional interaction with Fyn and phosphorylation of PLCgamma1...
  59. ncbi Phospholipase C gamma 2 is essential for specific functions of Fc epsilon R and Fc gamma R
    Renren Wen
    The Blood Research Institute, The Blood Center of Southeastern Wisconsin, Milwaukee, WI 53226, USA
    J Immunol 169:6743-52. 2002
    ..Moreover, PLCgamma2 plays a nonredundant role in Fc(gamma)R-mediated inflammatory skin reaction...
  60. pmc Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells
    Rafika Athman
    Laboratoire de Morphogenèse et Signalisation Cellulaires, Institut Curie Unité Mixte Recherche 144, 75248 Paris, France
    Mol Biol Cell 14:4641-53. 2003
    ..Collectively, these data demonstrate that villin acts as a regulator of HGF-induced actin dynamics...
  61. ncbi The PLC-PKC cascade is required for IL-1beta-dependent Erk and Akt activation: their role in proliferation
    A R M Ruhul Amin
    Laboratory of Molecular Pathogenesis, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Int J Oncol 23:1727-31. 2003
    ..Taken together, our results suggest that a SHPS-1-PLC-gamma complex activate the PLC-PKC cascade, which is required for the activation of IL-1beta-dependent Erk and Akt signalings and cell proliferation...
  62. ncbi Phosphatidylinositol 3-kinase, phosphoinositide-specific phospholipase-Cgamma and protein kinase-C signal myelin phagocytosis mediated by complement receptor-3 alone and combined with scavenger receptor-AI/II in macrophages
    Chen Makranz
    Department of Anatomy and Cell Biology, Hebrew University Hadassah Medical School and the Eric Roland Center for Neurodegenerative Diseases, Jerusalem, Israel
    Neurobiol Dis 15:279-86. 2004
    ..This pathway may thus be targeted for in vivo modulation, which may explain differences in the efficiency of CR3/MAC-1-mediated myelin phagocytosis in different pathological conditions...
  63. ncbi The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1
    Marika Arnould
    INSERM U531, Institut Louis Bugnard, IFR31, CHU Rangueil, Bat L3, Toulouse, France
    FEBS Lett 568:89-93. 2004
    ..A specific interaction was demonstrated using surface plasmon resonance, confirmed in a cellular system and by molecular modeling...
  64. ncbi Erythropoietin-modulated calcium influx through TRPC2 is mediated by phospholipase Cgamma and IP3R
    Qin Tong
    Department of Pediatrics, Milton S Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA
    Am J Physiol Cell Physiol 287:C1667-78. 2004
    ..Our data demonstrate that Epo-R modulates TRPC2 activation through PLCgamma; that interaction of IP(3)R with TRPC2 is required; and that Epo-R, TRPC2, PLCgamma, and IP(3)R interact to form a signaling complex...
  65. ncbi Integrin-dependent PLC-gamma1 phosphorylation mediates fibronectin-dependent adhesion
    Denis Tvorogov
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Cell Sci 118:601-10. 2005
    ..To assess PLC-gamma1 function in this process, Plcg1(-/-) fibroblasts (Null) were compared with the same fibroblasts in which PLC-gamma1 was re-expressed (Null+)...
  66. pmc Molecular cloning and characterization of a novel phospholipase C, PLC-eta
    Jong Ik Hwang
    Division of Molecular and Life Science, Department of Life Science, Pohang University of Science and Technology, Pohang 790 784, Korea
    Biochem J 389:181-6. 2005
    ..These results suggest that PLC-eta may perform fundamental roles in the brain...
  67. ncbi Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy
    Lawrence P Kane
    Department of Immunology, BST E 1056, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Biol Chem 280:21949-54. 2005
    ....
  68. ncbi Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
    Min Hee Choi
    Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
    Nature 435:347-53. 2005
    ..These results demonstrate a localized role for endogenous H2O2 in PDGF signalling, and indicate a biological function of Prx II in cardiovascular disease...
  69. ncbi PLCgamma1 is essential for early events in integrin signalling required for cell motility
    Neil P Jones
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London, UK
    J Cell Sci 118:2695-706. 2005
    ..This suggests a more general role for PLCgamma1 in cell motility, functioning as a mediator of both growth factor and integrin-initiated signals...
  70. ncbi Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma
    Adrienne Halupa
    Division of Stem Cell and Developmetal Biology, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Exp Cell Res 309:1-11. 2005
    ..Hence, we have identified a novel adapter function for PLCgamma1 in EPO signaling in which recruitment of PLCgamma1 to EPO-R may lead to activation of the ERK pathway...
  71. pmc NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity
    Takanobu Nakazawa
    Division of Oncology, Department of Cancer Biology, University of Tokyo, Tokyo, Japan
    EMBO J 25:2867-77. 2006
    ..We thus identify Tyr-1472 phosphorylation as a key mediator of fear learning and amygdaloid synaptic plasticity...
  72. ncbi Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice
    Maria H Johansson
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 177:7923-9. 2006
    ..This study describes the first important step toward identifying BM graft resistance gene(s)...
  73. ncbi Phospholipase Cgamma1 negatively regulates growth hormone signalling by forming a ternary complex with Jak2 and protein tyrosine phosphatase-1B
    Jang Hyun Choi
    National Research Laboratory of Signaling Network, Department of Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk, 790 784, Republic of Korea
    Nat Cell Biol 8:1389-97. 2006
    ..These results suggest that PLCgamma1 has a key function in the regulation of growth hormone-mediated signalling by negatively regulating Jak2 activation...
  74. ncbi Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain
    Tomi Rantamäki
    Neuroscience Center, University of Helsinki, PO Box 56, 00014 Helsinki, Finland
    Neuropsychopharmacology 32:2152-62. 2007
    ..In conclusion, our data suggest that rapid activation of the TrkB neurotrophin receptor and PLCgamma1 signaling is a common mechanism for all antidepressant drugs...
  75. ncbi Phospholipase Cgamma1 signalling regulates lipopolysaccharide-induced cyclooxygenase-2 expression in cardiomyocytes
    E Shen
    Center for Critical Illness Research, Lawson Health Research Institute, London Health Sciences Center, University of Western Ontario, London, Ontario, Canada N6A 4G5
    J Mol Cell Cardiol 43:308-18. 2007
    ..The Src family is responsible for PLCgamma1 activation, which signals the ERK1/2 MAPK pathway, resulting in COX-2 production in LPS-stimulated cardiomyocytes...
  76. ncbi Disruption of phospholipase Cgamma1 signalling attenuates cardiac tumor necrosis factor-alpha expression and improves myocardial function during endotoxemia
    Tianqing Peng
    Center for Critical Illness Research, Lawson Health Research Institute, VRL 6th Floor, 800 Commissioners Road, London, Ontario, Canada N6A 4G5
    Cardiovasc Res 78:90-7. 2008
    ..The purpose of this study was to investigate the role of phosphatidylinositol (PI) phospholipase Cgamma1 (PLCgamma1) in cardiac TNF-alpha expression, and myocardial dysfunction during endotoxemia...
  77. pmc Phospholipase Cgamma2 modulates integrin signaling in the osteoclast by affecting the localization and activation of Src kinase
    Holly Epple
    Washington University School of Medicine, Department of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Mol Cell Biol 28:3610-22. 2008
    ..Based on these results, we propose that PLCgamma2 influences Src activation by mediating the localization of Src to the integrin complex and thereby regulating integrin-mediated functions in the osteoclast...
  78. pmc Parkin-mediated ubiquitination regulates phospholipase C-gamma1
    Nodi Dehvari
    Department of NVS, Karolinska Institutet, KI Alzheimer s Disease Research Center, Stockholm, Sweden
    J Cell Mol Med 13:3061-8. 2009
    ..This finding could be of relevance for finding novel pathogenic mechanisms leading to PD...
  79. pmc Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway
    Anne Moenning
    Department of Developmental Pathology, Institute of Pathology, University of Bonn, Bonn, Germany
    Mol Cell Biol 29:881-91. 2009
    ..Thus, we show for the first time that PDGFRalpha signaling stimulates osteogenesis of NCC-derived osteoblasts by activating the PLC-gamma pathway, suggesting an involvement of this pathway in the etiology of human craniosynostosis...
  80. doi Phospholipase Cgamma2 is necessary for separation of blood and lymphatic vasculature in mice
    Hirotake Ichise
    Laboratory of Gene Expression and Regulation, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Development 136:191-5. 2009
    ..These findings indicate that PLCgamma2 plays an essential role in initiating and maintaining the separation of the blood and lymphatic vasculature...
  81. pmc PLC-gamma1 regulates fibronectin assembly and cell aggregation
    Cornelia E Crooke
    Department of Biochemistry, Vanderbilt University School of Medicine, 647 Light Hall, 21st Ave South Pierce, Nashville, TN 37232 2372, USA
    Exp Cell Res 315:2207-14. 2009
    ..Here, we examine the role of PLC-gamma1 in cell-matrix adhesion in a hanging drop assay of cell aggregation. Plcg1 Null (-/-) mouse embryonic fibroblasts formed aggregates that were larger and significantly more resistant to ..
  82. pmc Protein kinase C{gamma} mediates regulation of proliferation by the serotonin 5-hydroxytryptamine receptor 2B
    Mira M Wouters
    Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Miles and Shirley Fiterman Center for Digestive Diseases, Rochester, Minnesota 55905, USA
    J Biol Chem 284:21177-84. 2009
    ..The data demonstrate that the 5-HT(2B) receptor-induced proliferative response of ICC is through phospholipase C, [Ca(2+)](i), and PKCgamma, implicating this PKC isoform in the regulation of cellular proliferation...
  83. pmc Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling
    Guo Fu
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 10:848-56. 2009
    ..In support of the idea that Themis is involved in TCR signaling, this protein was phosphorylated quickly after TCR stimulation and was needed for optimal TCR-driven calcium mobilization and activation of the kinase Erk...
  84. doi VEGFR2-PLCgamma1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells
    Hitoshi Sase
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    J Cell Sci 122:3303-11. 2009
    ..Taken together, these findings indicate that VEGFR2-PLCgamma1 signal relay gives rise to the unique function of VEGFR2, thus enabling endothelial differentiation from vascular progenitors...
  85. doi Ca(2+)-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X(7) receptor-mediated phosphoinositide 3-kinase signaling
    Yu Peng Liu
    Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan
    J Neurochem 113:213-27. 2010
    ....
  86. pmc Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP
    Carlos E Irarrazabal
    Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1603, USA
    Proc Natl Acad Sci U S A 107:906-11. 2010
    ....
  87. pmc Phospholipase Cgamma activation drives increased production of autotaxin in endothelial cells and lysophosphatidic acid-dependent regression
    Eunok Im
    Schepens Eye Research Institute, Harvard Medical School, 20 Staniford St, Boston, MA 02114, USA
    Mol Cell Biol 30:2401-10. 2010
    ..These findings are likely to potentiate ongoing efforts to prevent, manage, and eradicate numerous angiogenesis-based diseases such as proliferative diabetic retinopathy and solid tumors...
  88. pmc CCR7/CCL21 migration on fibronectin is mediated by phospholipase Cgamma1 and ERK1/2 in primary T lymphocytes
    Laura A Shannon
    Department of Microbiology, Molecular Genetics, and Immunology, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Biol Chem 285:38781-7. 2010
    ..Overall, these results suggest that the CCR7 signaling pathway leading to T lymphocyte migration on fibronectin is a β1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCγ1...
  89. pmc PLCγ-activated signalling is essential for TrkB mediated sensory neuron structural plasticity
    Carla Sciarretta
    European Molecular Biology Laboratory, Mouse Biology Unit, Via Ramornie 32, 00015 Monterotondo, Rome, Italy
    BMC Dev Biol 10:103. 2010
    ..Dysfunction of the vestibular system can severely affect a person's quality of life. Therefore, understanding the molecular basis of vestibular neuron survival, maintenance, and innervation of the target sensory epithelia is fundamental...
  90. pmc c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1
    R D Meyer
    Department of Pathology, Boston University Medical Campus, Boston, MA 02118, USA
    Oncogene 30:2198-206. 2011
    ..Hence, we propose c-Cbl as an angiogenic suppressor protein where upon activation it uniquely modulates PLCγ1 activation by ubiquitination and subsequently inhibits VEGF-driven angiogenesis...
  91. ncbi Expression of phospholipase C isozymes by murine B lymphocytes
    W M Hempel
    Department of Microbiology and Immunology, University of California, San Francisco 94143
    J Immunol 146:3713-20. 1991
    ..b>PLC gamma 1 had a more complicated pattern of mRNA expression...
  92. ncbi Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1) map to distinct regions in the human and mouse genomes
    A C Argeson
    Jefferson Cancer Institute, Thomas Jefferson University, Department of Microbiology and Immunology, Philadelphia, Pennsylvania 19107 5541, USA
    Genomics 25:29-35. 1995
    ..Plcg2 does not map near its most closely related family member, Plcg1, in either genome, indicating that the mammalian Plcg genes belong to a dispersed family.
  93. ncbi Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed
    C M Williamson
    MRC Radiobiology Unit, Didcot, Oxon, UK
    Genet Res 65:83-93. 1995
    ..Mc3r and Ntsr) where a defect could lead to neurological and probably behavioural problems, and 3 genes (Cd40, Plcg1 and Rcad) that are less obvious candidates but sequence information was available for designing primers to test ..
  94. ncbi Localisation of the imprinted gene neuronatin, Nnat, confirms and refines the location of a second imprinting region on mouse chromosome 2
    C M Williamson
    Mammalian Genetics Unit, Medical Research Council, Harwell, Didcot, Oxfordshire UK
    Cytogenet Cell Genet 81:73-8. 1998
    ..It maps close to agouti, some alleles of which show differential expression according to parental origin. The localisation of Nnat to band H1 confirms and refines the map location of a second imprinting region on mouse Chr 2...
  95. ncbi cDNA and genomic cloning of mouse aquaporin-2: functional analysis of an orthologous mutant causing nephrogenic diabetes insipidus
    B Yang
    Department of Physiology, Cardiovascular Research Institute, San Francisco, California, 94143 0521, USA
    Genomics 57:79-83. 1999
    ..The chemical chaperone glycerol produced a redistribution of Aqp2-T126M from ER to plasma membrane/endosomes. These results establish a basis for an Aqp2-T126M transgenic knock-in model of NDI...
  96. pmc Phospholipase C-gamma1 is required for cell survival in oxidative stress by protein kinase C
    Xiao Chun Bai
    Department of Cell Biology and Medical Genetics, The First Military Medical University, Guangzhou 510515, People s Republic of China
    Biochem J 363:395-401. 2002
    ..survival signalling in oxidative stress by using mouse embryonic fibroblasts genetically deficient in PLC-gamma1 (Plcg1(-/-)) and its wild type (Plcg1(+/+))...
  97. ncbi Regulation of spontaneous meiosis resumption in mouse oocytes by various conventional PKC isozymes depends on cellular compartmentalization
    Nathalie Avazeri
    Institut National de la Santé et de la Recherche Médicale Unité 566 Commissariat à l Energie Atomique, 92260 Fontenay aux Roses CEDEX, France
    J Cell Sci 117:4969-78. 2004
    ..Further investigations are however necessary to discover the molecular targets of these cPKCs to better understand the links with the cell cycle progression...
  98. pmc Targeting of protein kinase C-epsilon during Fcgamma receptor-dependent phagocytosis requires the epsilonC1B domain and phospholipase C-gamma1
    Keylon L Cheeseman
    Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    Mol Biol Cell 17:799-813. 2006
    ..Together, these results support a model in which PI-PLC-gamma1 provides DAG that binds to epsilonC1B, facilitating PKC-epsilon localization to phagosomes for efficient IgG-mediated phagocytosis...
  99. ncbi Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCgamma
    Elena Vigorito
    Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Cell Signal 18:1455-60. 2006
    ..These findings show that Vav proteins and PI3K regulation of PLCgamma contributes to the activation of PKD in response to BCR and or CD19 cross-linking...
  100. pmc Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains
    Charles R Farber
    Department of Animal Science, University of California Davis, One Shields Ave, Davis, CA 95016 8521, USA
    BMC Genomics 7:102. 2006
    ..To confirm and further characterize each QTL, two panels of speed congenic strains were developed by introgressing CAST/EiJ (CAST) QTL alleles onto either mutant C57Bl/6J-hg/hg (HG) or wild type C57Bl/6J (B6) genetic backgrounds...
  101. ncbi Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo
    Yan Li
    Disciplines of Medicine and Physiology, University of Sydney, Royal North Shore Hospital, St Leonards, New South Wales 2065, Australia
    Biol Reprod 77:813-21. 2007
    ..The 2-cell embryo expressed three genes for AKT (Akt 1-3) and two genes for phospholipase C gamma (Plcg1 and Plcg2), and we confirmed the expression of both AKT and phospholipase C gamma 1 by immunolocalization...

Research Grants13

  1. PKC Theta--A Novel Drug Target in T Cell Leukemias
    Amnon Altman; Fiscal Year: 2003
    ..abstract_text> ..
  2. PKC theta in the Immune Synapse and T Cell Anergy
    Amnon Altman; Fiscal Year: 2003
    ..They offer the potential for developing novel therapeutic strategies, which may be useful for modulating CD28 costimulation in disease. ..
  3. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2006
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  4. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2007
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  5. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2010
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  6. INTEGRATION OF STRESS AND MITOGEN SIGNALING
    Jonathan Cooper; Fiscal Year: 2001
    ..4) To map the interactions between ERK and Msk using approaches such at the two-hybrid system. 5) To clone Mapkip108 using conventional techniques. ..
  7. Role of the JIP-1-p190RhoGEF Complex In Neuron Function
    WILLIAM ARTHUR; Fiscal Year: 2004
    ..Furthermore, the importance of the JIP-l-p190RhoGEF association in brain development and neuronal migration will be investigated by disrupting this complex in mutant mice . ..
  8. FUNCTION AND REGULATION OF VAV IN LYMPHOCYTE ACTIVATION
    Amnon Altman; Fiscal Year: 2005
    ....
  9. role of ubiquitinin in cancer progression
    Jin Ming Yang; Fiscal Year: 2005
    ..abstract_text> ..
  10. Drug Sensitivity of Calcium Modulators from Brain Tumor
    Jin Ming Yang; Fiscal Year: 2006
    ..Therefore, the overall goal of this proposal is to identify new drugs for the treatment of GBM. ..
  11. The Fourth International Leukocyte Signal Transduction Workshop: Clinical Implica
    Amnon Altman; Fiscal Year: 2007
    ..abstract_text> ..
  12. Regulation of NF-kB by the Akt kinase
    Lawrence P Kane; Fiscal Year: 2010
    ..Such knowledge may eventually lead to more specific and efficacious treatments for tumors with dysregulated Akt. ..
  13. CHARACTERIZATION OF A MAJOR OBESITY LOCUS
    Charles Farber; Fiscal Year: 2008
    ..Lastly, aim 3 uses a genetical genomics approach to map eQTL for genes within the congenic interval. Data from these aims will enhance our understanding of the genetics and physiology of obesity. ..