Pik3cb

Summary

Gene Symbol: Pik3cb
Description: phosphatidylinositol 3-kinase, catalytic, beta polypeptide
Alias: 1110001J02Rik, AI447572, p110beta, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, ptdIns-3-kinase subunit beta, ptdIns-3-kinase subunit p110-beta
Species: mouse

Top Publications

  1. pmc TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes
    Jaya Sahni
    Department of Pediatrics, University of Washington and Seattle Children s Hospital Research Institute, Seattle, WA 98101, USA
    Cell Metab 8:84-93. 2008
  2. pmc Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction
    Zhongju Lu
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8151, USA
    Circulation 120:318-25. 2009
  3. pmc The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
    Julie Guillermet-Guibert
    Center for Cell Signaling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 105:8292-7. 2008
  4. pmc Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
    Shidong Jia
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 454:776-9. 2008
  5. pmc Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development
    Elisa Ciraolo
    Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy
    Sci Signal 1:ra3. 2008
  6. doi Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages
    Evangelia A Papakonstanti
    Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    J Cell Sci 121:4124-33. 2008
  7. pmc Specific function of phosphoinositide 3-kinase beta in the control of DNA replication
    Miriam Marqués
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, Cantoblanco, Madrid E 28049, Spain
    Proc Natl Acad Sci U S A 106:7525-30. 2009
  8. pmc Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells
    Emmajayne Kingham
    Department of Pharmacy and Pharmacology and The Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Cell Sci 122:2311-21. 2009
  9. doi Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets
    Ilaria Canobbio
    Department of Biochemistry, University of Pavia, via Bassi 21, Pavia, Italy
    Blood 114:2193-6. 2009
  10. pmc The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy
    Zhixun Dou
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    J Cell Biol 191:827-43. 2010

Scientific Experts

  • Ronald W Matheny
  • Simone M Schoenwaelder
  • S F Jackson
  • Angel W Lee
  • Felix Junyent
  • Lazaros C Foukas
  • Kevin W Williams
  • Britta J Eickholt
  • Bart Vanhaesebroeck
  • Thomas M Roberts
  • Richard Z Lin
  • Julie Guillermet-Guibert
  • Jean J Zhao
  • Lisa M Ballou
  • Sang Hyun Lee
  • Emilio Hirsch
  • Ana C Carrera
  • Amit Kumar
  • Elisa Ciraolo
  • Tamara Utermark
  • Ya Ping Jiang
  • Shidong Jia
  • Qi Wang
  • Alessia Perino
  • Klaus Okkenhaug
  • Zhixun Dou
  • Zhongju Lu
  • Faruk Ramadani
  • Wayne Pearce
  • Miriam Marqués
  • Fabienne Schmit
  • Thanh Von
  • Reinhard Wetzker
  • Chia Yen C Wu
  • Antonio Bilancio
  • Len R Stephens
  • Phillip T Hawkins
  • Ira S Cohen
  • Olivier Zwaenepoel
  • Mohar Chattopadhyay
  • Sabina Signoretti
  • Mariona Graupera
  • Massimo Loda
  • Ilaria Canobbio
  • Fiorella Altruda
  • Matthias P Wymann
  • Evangelia A Papakonstanti
  • Andrew J H Smith
  • Yoshikazu Morishita
  • Onur Cizmecioglu
  • Jing Ni
  • Christina Gross
  • Brent A McLean
  • Haluk Yuzugullu
  • Anne J Ridley
  • Pavel Zhabyeyev
  • Gavin Y Oudit
  • Allan G Murray
  • Zamaneh Kassiri
  • George Haddad
  • Fubiao Shi
  • Matthew Beymer
  • Victoria L B Nelson
  • Roderick Bronson
  • Xueliang Gao
  • Christine M Lynch
  • Borja L Holgado
  • Jian bin Huang
  • L Cipolla
  • Ralph Fritsch
  • Sauveur Michel Maira
  • Giuseppe Lembo
  • Alessandra Ghigo
  • Karolina Błajecka
  • Alessandra Consonni
  • Inma M Berenjeno
  • Vicente Perez-García
  • Virginia Silio
  • Javier Redondo-Muñoz
  • Wei Xing Zong
  • Ji An Pan
  • Mohamed M Bekhite
  • Keith B Boyle
  • Daisuke Ikegami
  • Suhasini Kulkarni
  • Karen E Anderson
  • Attila Mocsai
  • Sen Zhang
  • Zhi Wei Ye
  • Xuxiao Zhang

Detail Information

Publications82

  1. pmc TRPM7 ion channels are required for sustained phosphoinositide 3-kinase signaling in lymphocytes
    Jaya Sahni
    Department of Pediatrics, University of Washington and Seattle Children s Hospital Research Institute, Seattle, WA 98101, USA
    Cell Metab 8:84-93. 2008
    ....
  2. pmc Loss of cardiac phosphoinositide 3-kinase p110 alpha results in contractile dysfunction
    Zhongju Lu
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8151, USA
    Circulation 120:318-25. 2009
    ..The aim of this study was to evaluate whether p110alpha also controls cardiac contractility by regulating the LTCC...
  3. pmc The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
    Julie Guillermet-Guibert
    Center for Cell Signaling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 105:8292-7. 2008
    ..The class IA PI3K catalytic subunits (p110alpha, p110beta, and p110delta) occur in complex with a Src homology 2 (SH2) domain-containing p85 regulatory subunit, which has ..
  4. pmc Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis
    Shidong Jia
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 454:776-9. 2008
    On activation by receptors, the ubiquitously expressed class IA isoforms (p110alpha and p110beta) of phosphatidylinositol-3-OH kinase (PI(3)K) generate lipid second messengers, which initiate multiple signal transduction cascades...
  5. pmc Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development
    Elisa Ciraolo
    Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Via Nizza 52, 10126 Torino, Italy
    Sci Signal 1:ra3. 2008
    ..Although different PI3K catalytic subunits are known to play distinct roles, the specific in vivo function of p110beta (the product of the PIK3CB gene) is not clear...
  6. doi Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages
    Evangelia A Papakonstanti
    Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    J Cell Sci 121:4124-33. 2008
    The class IA isoforms of phosphoinositide 3-kinase (p110alpha, p110beta and p110delta) often have non-redundant functions in a given cell type...
  7. pmc Specific function of phosphoinositide 3-kinase beta in the control of DNA replication
    Miriam Marqués
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Universidad Autonoma de Madrid, Cantoblanco, Madrid E 28049, Spain
    Proc Natl Acad Sci U S A 106:7525-30. 2009
    ..We report here a unique function for PI3Kbeta in the control of DNA replication...
  8. pmc Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells
    Emmajayne Kingham
    Department of Pharmacy and Pharmacology and The Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Cell Sci 122:2311-21. 2009
    ..Pharmacological inhibition or knockdown of p110beta promoted mESC differentiation, accompanied by a decrease in expression of Nanog...
  9. doi Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets
    Ilaria Canobbio
    Department of Biochemistry, University of Pavia, via Bassi 21, Pavia, Italy
    Blood 114:2193-6. 2009
    Phosphatidylinositol 3-kinase (PI3K) isoforms PI3Kbeta and PI3Kgamma are implicated in platelet adhesion, activation, and aggregation, but their relative contribution is still unclear or controversial...
  10. pmc The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy
    Zhixun Dou
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    J Cell Biol 191:827-43. 2010
    ..Our results unveil a previously unknown function for p110-β as a positive regulator of autophagy in multicellular organisms...
  11. pmc The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis
    Tamara Utermark
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 26:1573-86. 2012
    ..Our findings demonstrate a novel p110β-based regulatory role in receptor-mediated PI3K activity and identify p110α as an important target for treatment of HER2-positive disease...
  12. doi PI3Kβ plays a critical role in neutrophil activation by immune complexes
    Suhasini Kulkarni
    Inositide Laboratory, The Babraham Institute, Cambridge CB22 3AT, UK
    Sci Signal 4:ra23. 2011
    ..These results define PI3Kβ as a potential therapeutic target in inflammatory disease...
  13. pmc Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility
    Elisa Ciraolo
    Molecular Biotechnology Center, Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
    Mol Biol Cell 21:704-11. 2010
    ..Herein, we report that male mice expressing a catalytically inactive p110beta develop testicular hypotrophy and impaired spermatogenesis, leading to a phenotype of oligo-azoospermia and ..
  14. doi Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo
    Valerie Martin
    INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Département d Oncogenèse, Signalisation et Innovation thérapeutique, and Université Toulouse III Paul Sabatier, Toulouse, France
    Blood 115:2008-13. 2010
    ..Here, we generated a megakaryocyte-restricted p110beta null mouse model and demonstrated a critical role of PI3Kbeta in platelet activation via an immunoreceptor tyrosine-based activation motif, the glyco-protein VI-Fc receptor ..
  15. pmc Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair
    Amit Kumar
    Department of Immunology and Oncology, Centro Nacional de Biotecnología Consejo Superior de Investigaciones Científicas, Madrid E 28049, Spain
    Proc Natl Acad Sci U S A 107:7491-6. 2010
    ..Expression of the phosphoinositide 3-kinase beta (PI3Kbeta) isoform, but not its activity, is essential for early embryonic development...
  16. pmc Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism
    Xuxiao Zhang
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Mol Cell 41:567-78. 2011
    ..This contrasts with the nSH2 where the pY-binding site itself forms the inhibitory contact. This establishes an unusual mechanism by which p85 SH2 domains contribute to RTK signaling specificities...
  17. pmc Activity of any class IA PI3K isoform can sustain cell proliferation and survival
    Lazaros C Foukas
    Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, London EC1M 6BQ, United Kingdom
    Proc Natl Acad Sci U S A 107:11381-6. 2010
    ..inactivation of either p110alpha or p110delta did not affect cell proliferation or survival or sensitize to p110beta or p110gamma inactivation...
  18. doi Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae
    Keith B Boyle
    Inositide Laboratory, Babraham Institute, Cambridge CB22 3AT, United Kingdom
    J Immunol 186:2978-89. 2011
    ..These results start to define the signaling network controlling neutrophil ROS responses to A. fumigatus hyphae...
  19. doi Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration
    Mariona Graupera
    Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK
    Nature 453:662-6. 2008
    ..Class IA PI3K isoforms couple to tyrosine kinases and consist of a p110 catalytic subunit (p110alpha, p110beta or p110delta), constitutively bound to one of five distinct p85 regulatory subunits...
  20. pmc Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase
    Miriam Marqués
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Darwin 3, Cantoblanco, Madrid E 28049, Spain
    Mol Cell Biol 28:2803-14. 2008
    ..The two ubiquitous PI3K isoforms (p110alpha and p110beta) are essential during embryonic development and are thought to control cell division...
  21. ncbi Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase
    Lei Bi
    Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 4472, USA
    Mamm Genome 13:169-72. 2002
  22. ncbi Essential role for the p110delta phosphoinositide 3-kinase in the allergic response
    Khaled Ali
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Nature 431:1007-11. 2004
    ..Inactivation of p110delta protects mice against anaphylactic allergic responses. These results identify p110delta as a new target for therapeutic intervention in allergy and mast-cell-related pathologies...
  23. pmc Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice
    Saskia M Brachmann
    Beth Israel Hospital, NRB, Division of Signal Transduction, Department of Systems Biology, 10th Floor, 330, Brookline, MA 02215, USA
    Mol Cell Biol 25:1596-607. 2005
    ..is particularly unexpected in p85alpha-/- p55alpha-/- p50alpha-/- mice, where a decrease in p110alpha and p110beta catalytic subunits was observed in insulin-sensitive tissues...
  24. ncbi PI 3-kinase p110beta: a new target for antithrombotic therapy
    Shaun P Jackson
    Australian Centre for Blood Diseases, Monash University, 6th Floor Burnet Building Alfred Medical Research and Education Precinct, Prahran, Victoria, Australia 3181
    Nat Med 11:507-14. 2005
    ..In this study we have defined a key role for the Type Ia phosphoinositide 3-kinase (PI3K) p110beta isoform in regulating the formation and stability of integrin alpha(IIb)beta(3) adhesion bonds, necessary for ..
  25. ncbi Regulation of membrane traffic by phosphoinositide 3-kinases
    Karine Lindmo
    Department of Biochemistry, Norwegian Radium Hospital and University of Oslo, Montebello, N 0310 Oslo, Norway
    J Cell Sci 119:605-14. 2006
    ..By contrast, class III PI 3-kinases mainly mediate receptor-independent trafficking events, which mostly are related to endocytic membrane traffic, phagosome maturation and autophagy...
  26. ncbi Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation
    Lazaros C Foukas
    Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK
    Nature 441:366-70. 2006
    ..of p110alpha derives from its highly selective recruitment and activation to IRS signalling complexes compared to p110beta, the other broadly expressed PI(3)K isoform, which did not contribute to IRS-associated PI(3)K activity...
  27. pmc Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss
    Onur Cizmecioglu
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, United States
    elife 5:. 2016
    ..Collectively, our findings provide a mechanistic account of how membrane raft localization regulates differential activation of distinct PI3K isoforms and offer insight into why PTEN-deficient cancers depend on p110β...
  28. doi PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter
    Yoshikazu Morishita
    a Faculty of Applied Bioscience, Department of Bioscience, Tokyo University of Agriculture, Tokyo, Japan
    Biosci Biotechnol Biochem 80:1131-40. 2016
    ..Our findings suggest that PI3K signaling plays a modulatory role in the regulation of the transcriptional rhythm of the Dbp gene by targeting BMAL1 and CLOCK. ..
  29. pmc A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis
    Haluk Yuzugullu
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Nat Commun 6:8501. 2015
    ....
  30. pmc Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells
    Julie Guillermet-Guibert
    UCL Cancer Institute, University College London, London, United Kingdom Centre de Recherche en Cancérologie de Toulouse UMR1037, INSERM, BP84225, Toulouse, France Université Toulouse III Paul Sabatier, Toulouse, France
    PLoS Genet 11:e1005304. 2015
    ..This developmental pathway may become active in prostate cancer where p110β and AR have previously been reported to functionally interact. ..
  31. pmc Phosphoinositide 3-kinase β regulates chromosome segregation in mitosis
    Virginia Silio
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma de Madrid, Cantoblanco, Madrid E 28049, Spain
    Mol Biol Cell 23:4526-42. 2012
    ..These results reveal a p110β function in preserving genomic stability during mitosis...
  32. doi CXCL12-mediated murine neural progenitor cell movement requires PI3Kβ activation
    Borja L Holgado
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Darwin 3, Cantoblanco, 28049, Madrid, Spain
    Mol Neurobiol 48:217-31. 2013
    ..We conclude that PI3K p110β is activated in NPC in response to CXCL12, and its activity is necessary for immature interneuron migration to the cerebral cortex...
  33. pmc Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA Electronic address
    Cell Rep 11:681-8. 2015
    ..Our results suggest that FMRP-mediated control of p110β is crucial for neuronal protein synthesis and cognition...
  34. doi PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart
    Brent A McLean
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    Cardiovasc Res 105:292-303. 2015
    ..Here we seek to clarify the role of PI3Kα in normal heart physiology and investigate changes in related signalling pathways...
  35. doi Combined inhibition of PI3Kβ and PI3Kγ reduces fat mass by enhancing α-MSH-dependent sympathetic drive
    Alessia Perino
    Molecular Biotechnology Center, Department of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy
    Sci Signal 7:ra110. 2014
    ..These results suggest that combined inhibition of PI3Kβ and PI3Kγ might represent a promising treatment for obesity. ..
  36. doi A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice
    Fubiao Shi
    State Key Laboratory of Genetic Engineering and National Center for International Research of Development and Disease, Institute of Developmental Biology and Molecular Medicine, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200433, China
    Hum Mol Genet 23:3792-800. 2014
    ..Therefore, this mutant presents an excellent animal model for mechanistic study of BPES and regulation of Foxl2. ..
  37. pmc Kisspeptin cell-specific PI3K signaling regulates hypothalamic kisspeptin expression and participates in the regulation of female fertility
    Matthew Beymer
    Department of Physiology and Biophysics, Stony Brook University Medical Center, Stony Brook, New York Graduate Program in Genetics, Stony Brook University, Stony Brook, New York
    Am J Physiol Endocrinol Metab 307:E969-82. 2014
    ..Our data show that PI3K signaling is important for the regulation of hypothalamic kisspeptin expression and contributes to normal fertility in females. ..
  38. pmc Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity
    Victoria L B Nelson
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York
    Am J Physiol Endocrinol Metab 306:E1205-16. 2014
    ....
  39. doi Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy
    George Haddad
    Department of Medicine
    Blood 124:2142-9. 2014
    ..In vivo, PI3Kβ-knockdown ECs are deficient in assembly of microvessel-like structures. These data identify a critical role for endothelial PI3Kβ in microvascular repair following injury. ..
  40. pmc The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type
    Tamara Utermark
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA Department of Biochemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 88:10673-9. 2014
    ..Since the tumor formation driven by MT is p110α dependent in the prostate as well as in the mammary gland, our data suggest that PI3K isoform dependence is driven by the mode of PI3K pathway activation rather than by tissue type...
  41. pmc PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
    Fabienne Schmit
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115
    Proc Natl Acad Sci U S A 111:6395-400. 2014
    ..Taken together, our data suggest that, whereas in some tissues PTEN-null tumors appear to inherently depend on p110β, the p110 isoform reliance of PTEN-deficient tumors may be altered by concurrent mutations that activate p110α. ..
  42. ncbi Phosphoinositide 3-kinase activity leads to silica-induced NF-kappaB activation through interacting with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB
    Jihee Lee Kang
    Department of Physiology, College of Medicine, Division of Cell Biology, Ewha Medical Research Center, Ewha Womans University, Seoul, Korea
    Mol Cell Biochem 248:17-24. 2003
    ..Our data suggest that p85 and p110 subunits of PI3-kinase play a role in NF-kappaB activation through interaction with tyrosine-phosphorylated I(kappa)B-alpha and contributing to tyrosine phosphorylation of p65 NF-kappaB...
  43. ncbi H-2f, a tenth allele at the histocompatibility-2 locus in the mouse as determined by tumor transplantation
    S L Allen
    Cancer Res 15:315-9. 1955
  44. pmc Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia
    Joel Désiré Kamda
    Department of Biology, Reiss 406, Georgetown University, Washington, DC 20057, USA
    Infect Immun 77:685-93. 2009
    ..These data suggest that this parasite actively interferes with host innate immunity, resulting in an immune response able to control the infection but devoid of strong inflammatory signals...
  45. pmc Phosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with Dbl
    Karolina Błajecka
    Department of Clinical Research, University of Bern, Bern, Switzerland
    PLoS ONE 7:e44945. 2012
    ..Taken together, these findings suggest that PI3KC2β modulates the cell morphology and survival through a specific interaction with Dbl and the activation of RhoA...
  46. pmc The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development
    Faruk Ramadani
    1Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK
    Sci Signal 3:ra60. 2010
    ..Here, we show that p110alpha, but not p110beta, compensated in the absence of p110delta to promote early B cell development in the bone marrow and B cell ..
  47. doi Lysophosphatidic acid-stimulated phosphorylation of PKD2 is mediated by PI3K p110β and PKCδ in myoblasts
    Christine M Lynch
    US Army Research Institute of Environmental Medicine, Military Performance Division, Natick, MA 01760, USA
    J Recept Signal Transduct Res 33:41-8. 2013
    ....
  48. pmc Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention
    Shidong Jia
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer Discov 3:44-51. 2013
    ....
  49. doi Inhibition of the PI3K/AKT pathway reduces tumor necrosis factor-alpha production in the cellular response to wear particles in vitro
    Jian bin Huang
    Department of Orthopaedic Surgery, Sun Yat sen Memorial Hospital of Sun Yat sen University, 107 Yanjiangxi Road, Guangzhou, China
    Artif Organs 37:298-307. 2013
    ..The subunits of PI3K (p110β and p85β), followed by activation of phosphor-AKT (Ser473), participated in the regulation of activating macrophages by wear particles, ultimately resulting in the secretion of TNF-α...
  50. pmc Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation
    Zhixun Dou
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    Mol Cell 50:29-42. 2013
    ..Hence, in mammalian cells, p110β acts as a molecular sensor for growth factor availability and induces autophagy by activating a Rab5-mediated signaling cascade...
  51. pmc RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms
    Ralph Fritsch
    Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Cell 153:1050-63. 2013
    ..These findings revise our understanding of the regulation of type I PI3K by showing that both RAS and RHO family GTPases directly regulate distinct ubiquitous PI3K isoforms and that RAC activates p110β downstream of GPCRs...
  52. pmc Spatially distinct roles of class Ia PI3K isoforms in the development and maintenance of PTEN hamartoma tumor syndrome
    Qi Wang
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02215, USA
    Genes Dev 27:1568-80. 2013
    ....
  53. doi The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling
    L Cipolla
    Department of Biology and Biotechnology, University of Pavia, Pavia, Italy
    J Thromb Haemost 11:345-56. 2013
    ..The proline-rich tyrosine kinase Pyk2 is a focal adhesion kinase expressed in blood platelets, and is activated downstream of G-protein coupled receptors as well as integrin α2β1...
  54. doi Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance
    Alex M Wolf
    Committee on Developmental Biology, The University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 28:3456-67. 2008
    ..Therefore, we propose that atypical PKC signaling is required for Wnt-mediated A-P axon guidance and that PI3K can act as a switch to activate Wnt responsiveness during midline crossing...
  55. pmc Phosphoinositide-3-kinase-dependent, MyD88-independent induction of CC-type chemokines characterizes the macrophage response to Toxoplasma gondii strains with high virulence
    Chiang W Lee
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Infect Immun 75:5788-97. 2007
    ....
  56. pmc Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
    Britta J Eickholt
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS ONE 2:e869. 2007
    ..Our data identify p110delta as an important signaling component for efficient axonal elongation in the developing and regenerating nervous system...
  57. ncbi Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets
    Simone M Schoenwaelder
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct AMREP, 89 Commercial Road, Melbourne, Victoria, Australia
    J Biol Chem 282:28648-58. 2007
    ..These findings have potentially important implications for the rationale design of novel antiplatelet therapies targeting PI 3-kinase signaling pathways...
  58. ncbi Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fc gamma receptor ligation in murine macrophages
    Swamy Kumar Polumuri
    Department of Microbiology and Immunology, School of Medicine, University of Maryland, 660 West Redwood Street, Baltimore, MD 21201, USA
    J Immunol 179:236-46. 2007
    ..Thus, FcgammaR ligation modulates LPS-induced IL-12 via multiple PI3K-sensitive pathways that affect production, accumulation, and binding of key DNA-binding proteins required for IL-12 induction...
  59. ncbi Class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophages
    Yann Leverrier
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London W1W 7BS, United Kingdom
    J Biol Chem 278:38437-42. 2003
    ..Mammals have three genes for the class IA p110 subunits encoding p110alpha, p110beta, and p110delta and one gene for the class IB p110 subunit encoding p110gamma...
  60. pmc Suppression of phosphoinositide 3-kinase signaling and alteration of multiple ion currents in drug-induced long QT syndrome
    Zhongju Lu
    Department of Physiology and Biophysics and the Institute for Molecular Cardiology, Stony Brook University, Stony Brook, NY 11794, USA
    Sci Transl Med 4:131ra50. 2012
    ..This mechanism may explain why some tyrosine kinase inhibitors in clinical use are associated with increased risk of life-threatening arrhythmias...
  61. pmc Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor
    Inma M Berenjeno
    Centre for Cell Signalling, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Biochem J 442:151-9. 2012
    ..The potential implications of these findings for PI3K-targeted therapy of cancer are discussed...
  62. doi Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling
    Alessandra Consonni
    Department of Biochemistry, University of Pavia, Italy
    Blood 119:847-56. 2012
    ..These results demonstrate that Pyk2 regulates PI3Kβ downstream of integrin α2β1, and document a novel role for Pyk2 and PI3Kβ in integrin α2β1 promoted inside-out activation of integrin αIIbβ3 and thrombus formation...
  63. doi Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinase
    Olivier Zwaenepoel
    Department of Biochemistry, School of Medicine, University of Crete, Heraklion, Greece
    FASEB J 26:691-706. 2012
    ..These findings may have important implications in cancer development...
  64. doi Silencing p110β prevents rapid depletion of nuclear pAkt
    Zhi Wei Ye
    Institute of Environmental Medicine, Karolinska Institutet, S 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 415:613-8. 2011
    ..They also provide support for a chemopreventive effect of statins mediated by depletion of nuclear pAkt...
  65. doi VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells
    Mohamed M Bekhite
    Department of Internal Medicine I, Cardiology Division, Friedrich Schiller University, 07743 Jena, Germany
    J Cell Sci 124:1819-30. 2011
    ..Akt downstream of PI3K is involved in both cardiomyogenesis and vasculogenesis, whereas PKC is involved only in vasculogenesis...
  66. pmc Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces
    Simone M Schoenwaelder
    Australian Centre for Blood Diseases, Monash University, Alfred Medical Research and Education Precinct, 89 Commercial Road, Melbourne, Victoria 3004, Australia
    J Biol Chem 285:2886-96. 2010
    ..These findings may provide new insight into the potential antithrombotic properties of PI3K p110 beta inhibitors...
  67. pmc Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival
    Amit Kumar
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, Darwin 3, Campus de Cantoblanco, Madrid E 28049, Spain
    Mol Cell Biol 31:2122-33. 2011
    ..These studies show that p110β NLS and p85β NES regulate p85β/p110β nuclear localization, supporting the idea that nuclear, but not cytoplasmic, p110β controls cell survival...
  68. pmc Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
    Kevin Kyungsuk Park
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 322:963-6. 2008
    ..Thus, our results suggest the manipulation of intrinsic growth control pathways as a therapeutic approach to promote axon regeneration after CNS injury...
  69. doi Gene expression profile in JNK3 null mice: a novel specific activation of the PI3K/AKT pathway
    Felix Junyent
    Unitat de Farmacologia i Farmacognosia, Facultat de Farmacia, Institut de Biomedicina IBUB, Centros de Investigación Biomédica en Red de Enfermedades Neurodegenerativas CIBERNED, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 117:244-52. 2011
    ..Results from Jnk3 null mice showed an increase in pik3cb transcript and protein, together with an increase in PI3K activity and phosphorylation of AKT...
  70. pmc Appl1 is dispensable for Akt signaling in vivo and mouse T-cell development
    Yinfei Tan
    Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Genesis 48:531-9. 2010
    ..Collectively, our findings indicate that Appl1 is dispensable for Akt signaling in vivo and T-cell differentiation...
  71. pmc A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice
    Sang Hyun Lee
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:11002-7. 2010
    Recent work has shown that ablation of p110beta, but not p110alpha, markedly impairs tumorigenesis driven by loss of phosphatase and tensin homolog (PTEN) in the mouse prostate...
  72. ncbi Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells
    A W M Lee
    Department of Pharmacology, University of Michigan Medical School, 1150W Medical Center Dr, Ann Arbor, MI 48109, USA
    Cell Death Differ 13:1900-14. 2006
    ..This study identifies robust PI3-kinase activation as essential for optimal CSF-1-mediated mitogenesis in myeloid cells, in part through regulation of HKII and support of glycolysis...
  73. doi Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways
    Daisuke Ikegami
    Departments of Bone and Cartilage Biology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Development 138:1507-19. 2011
    ..Thus, continued expression of Sox9 in differentiated chondrocytes is essential for subsequent hypertrophy and sustains chondrocyte-specific survival mechanisms by binding to the Pik3ca promoter, inducing Akt phosphorylation...
  74. pmc Ablation of PI3K p110-α prevents high-fat diet-induced liver steatosis
    Mohar Chattopadhyay
    Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA
    Diabetes 60:1483-92. 2011
    ..To determine whether the phosphoinositide 3-kinase (PI3K) catalytic subunits p110-α and p110-β play a role in liver steatosis induced by a high-fat diet (HFD)...
  75. pmc Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ
    Alessia Perino
    Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, Torino 10126, Italy
    Mol Cell 42:84-95. 2011
    ..Pharmacological inhibition of p110γ normalizes β-adrenergic receptor density and improves contractility in failing hearts...
  76. ncbi The PI3K inhibitor arsenal: choose your weapon!
    Tom Crabbe
    UCB Celltech, Slough, UK
    Trends Biochem Sci 32:450-6. 2007
    ..However, challenges remain for the efforts to pharmacologically target this enzyme family in a successful manner...
  77. doi PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP
    Bryan Heit
    Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, T2N 4N1, Canada
    J Cell Sci 121:205-14. 2008
    ..Together, these data demonstrate that, although PI3K can enhance early responses to the bacterial chemoattractant fMLP, it is not required for migration towards this chemoattractant...
  78. pmc Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons
    Hind Al-Qassab
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London WC1E 6JJ, UK
    Cell Metab 10:343-54. 2009
    ..We inactivated either p110alpha or p110beta PI3K catalytic subunits in these neurons and demonstrate a dominant role for the latter in energy homeostasis ..
  79. pmc PI3Ks maintain the structural integrity of T-tubules in cardiac myocytes
    Chia Yen C Wu
    Department of Physiology and Biophysics and Institute of Molecular Cardiology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 6:e24404. 2011
    ..Although regulation of cardiac contraction by individual PI3K isoforms has been studied, little is known about the cardiac consequences of downregulating multiple PI3Ks concurrently...
  80. pmc The acute effects of leptin require PI3K signaling in the hypothalamic ventral premammillary nucleus
    Kevin W Williams
    Division of Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 31:13147-56. 2011
    ....
  81. pmc Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation
    Karen Gilio
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
    J Biol Chem 284:33750-62. 2009
    ..This provides a new mechanistic explanation for the anti-thrombotic effect of PI3K inhibition and makes PI3Kalpha an interesting new target for anti-platelet therapy...
  82. pmc PI3K p110 alpha and p110 beta have differential effects on Akt activation and protection against oxidative stress-induced apoptosis in myoblasts
    R W Matheny
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Cell Death Differ 17:677-88. 2010
    ..Overall, our results provide new evidence for the roles of p110 isoforms in promoting cellular proliferation and homeostasis, IGF-IR internalization, and in opposing apoptosis...