Picalm

Summary

Gene Symbol: Picalm
Description: phosphatidylinositol binding clathrin assembly protein
Alias: CALM, CLTH, PAP180, fit-1, fit1, mKIAA4114, phosphatidylinositol-binding clathrin assembly protein, clathrin assembly lymphoid myeloid leukemia
Species: mouse

Top Publications

  1. pmc The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse
    Julia Grizenkova
    MRC Prion Unit and Department of Neurodegenerative Diseases, UCL Institute of Neurology, University College, London, United Kingdom
    PLoS ONE 5:e15019. 2010
  2. ncbi Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7
    M D Potter
    University of Tennessee Oak Ridge Graduate School of Biomedical Sciences 37831 8077, USA
    Mamm Genome 6:70-5. 1995
  3. ncbi Mutations in the murine fitness 1 gene result in defective hematopoiesis
    M D Potter
    University of Tennessee Oak Ridge Graduate School of Biomedical Sciences, and the Biology Division of the Oak Ridge National Laboratory, 37831 8077, USA
    Blood 90:1850-7. 1997
  4. pmc The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice
    Mai Suzuki
    Department of Biological Science, Graduate School of Humanities and Sciences, Nara Women s University, Nara, Japan
    PLoS ONE 7:e31854. 2012
  5. ncbi Radiographic, histologic, and cytologic lesions associated with mutations in the fitness1(4226SB) locus of mice
    A E Schultze
    Department of Pathology, The University of Tennessee, Knoxville 37901 1071, USA
    Lab Anim Sci 49:260-8. 1999
  6. pmc Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice
    Mitchell L Klebig
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA
    Proc Natl Acad Sci U S A 100:8360-5. 2003
  7. doi Evidence for CALM in directing VAMP2 trafficking
    Asaff Harel
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Traffic 9:417-29. 2008
  8. pmc Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons
    Ittai Bushlin
    Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 28:10257-71. 2008
  9. pmc Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia
    Mai Suzuki
    Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 105:315-23. 2014
  10. pmc Reduction of AP180 and CALM produces defects in synaptic vesicle size and density
    Ronald S Petralia
    Advanced Imaging Core, NIDCD NIH, Bethesda, MD 20892, USA
    Neuromolecular Med 15:49-60. 2013

Research Grants

Scientific Experts

  • A Stoddart
  • Mitchell L Klebig
  • E M Rinchik
  • Kristopher R Schwab
  • Mai Suzuki
  • Kunihiko Kanatsu
  • Toshio Watanabe
  • Ronald S Petralia
  • Ittai Bushlin
  • Pamela J Yao
  • Mark P Mattson
  • Fangbai Wu
  • Asaff Harel
  • Takeshi Iwatsubo
  • Takahiro Maeda
  • Manami Maeda
  • Zhen Zhao
  • Yuichi Ishikawa
  • Niclas Gimber
  • Taisuke Tomita
  • Paula B Scotland
  • Qingli Xiao
  • Jenny Schlesinger
  • Julia Grizenkova
  • M D Potter
  • Sho Takatori
  • Yukiko Hori
  • Abhay P Sagare
  • Ethan A Winkler
  • Julie A Schneider
  • Tanja Maritzen
  • Gabriel Si
  • Nelly Chuqui Owens
  • Takahisa Kanekiyo
  • Sung Uk Lee
  • Maria Ericsson
  • Tohru Sugawara
  • François Aguet
  • Jian Xu
  • Pan Kong
  • Matthew R Halliday
  • Qingyi Ma
  • John Heuser
  • Ashim Ahuja
  • Ann Mullally
  • Donghui Zhu
  • Mithun Pasham
  • Sanket V Rege
  • Guojun Bu
  • Jan Schmoranzer
  • Carol A Miller
  • Anita Ramanathan
  • Georgi Tadeus
  • Hai Yi
  • Julie Teruya-Feldstein
  • Silvia K Tacheva-Grigorova
  • Takeshi Masuda
  • Tom Kirchhausen
  • Justin K Ichida
  • Kassandra Kisler
  • Berislav V Zlokovic
  • Volker Haucke
  • Kazutsune Yamagata
  • Yukiko Aikawa
  • Mika Shino
  • Koichi Akashi
  • Issay Kitabayashi
  • Yuichi Morohashi
  • Hiromasa Kuroda
  • Fred E Indig
  • Ya Xian Wang
  • Takaya Abe
  • Yan Wang
  • So Chon Gil
  • Yuzuru Kanakura
  • Natsuko Oe
  • Jennifer A Walker
  • Ronaldo Perez
  • Hirokazu Tanaka
  • Jessica L Heath
  • Sharon Han
  • Jin Moo Lee
  • Ernie Gonzales
  • Catherine P Lavau
  • John R Cirrito
  • Kenji Tanabe
  • Daniel S Wechsler
  • Shinya Rai
  • Kohji Takei
  • Manabu Fukumoto

Detail Information

Publications23

  1. pmc The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse
    Julia Grizenkova
    MRC Prion Unit and Department of Neurodegenerative Diseases, UCL Institute of Neurology, University College, London, United Kingdom
    PLoS ONE 5:e15019. 2010
    ..Because of the increasing overlap described between prion and Alzheimer's diseases we also chose Clu, Picalm and Cr1, which were identified as part of Alzheimer's disease GWAS...
  2. ncbi Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7
    M D Potter
    University of Tennessee Oak Ridge Graduate School of Biomedical Sciences 37831 8077, USA
    Mamm Genome 6:70-5. 1995
    Mutations at the fit1 locus affect normal pre- and post-natal development by retarding growth and reducing viability...
  3. ncbi Mutations in the murine fitness 1 gene result in defective hematopoiesis
    M D Potter
    University of Tennessee Oak Ridge Graduate School of Biomedical Sciences, and the Biology Division of the Oak Ridge National Laboratory, 37831 8077, USA
    Blood 90:1850-7. 1997
    ..We report here that fit1 mutants are anemic, display numerous peripheral blood defects, and are deficient in early hematopoietic progenitor ..
  4. pmc The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice
    Mai Suzuki
    Department of Biological Science, Graduate School of Humanities and Sciences, Nara Women s University, Nara, Japan
    PLoS ONE 7:e31854. 2012
    b>Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, which results from the chromosomal ..
  5. ncbi Radiographic, histologic, and cytologic lesions associated with mutations in the fitness1(4226SB) locus of mice
    A E Schultze
    Department of Pathology, The University of Tennessee, Knoxville 37901 1071, USA
    Lab Anim Sci 49:260-8. 1999
    ..Previous investigation of fitness1(4226SB) mice revealed growth retardation and microcytic, hypochromic anemia with functional iron deficiency. Serum biochemical analysis suggested protein-losing enteropathy and liver dysfunction...
  6. pmc Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 mice
    Mitchell L Klebig
    Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA
    Proc Natl Acad Sci U S A 100:8360-5. 2003
    ..point mutations in the mouse ortholog of the human phosphatidylinositol-binding clathrin assembly protein (PICALM) gene, whose product is involved in clathrin-mediated endocytosis...
  7. doi Evidence for CALM in directing VAMP2 trafficking
    Asaff Harel
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
    Traffic 9:417-29. 2008
    b>Clathrin assembly lymphoid myeloid leukemia protein (CALM) is a clathrin assembly protein with a domain structure similar to the neuron-specific assembly protein AP180...
  8. pmc Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons
    Ittai Bushlin
    Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
    J Neurosci 28:10257-71. 2008
    ..The clathrin assembly proteins AP180 and CALM (clathrin assembly lymphoid myeloid protein) are known to be involved in clathrin-mediated endocytosis, but their ..
  9. pmc Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemia
    Mai Suzuki
    Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 105:315-23. 2014
    ..Wild-type clathrin assembly lymphoid myeloid leukemia protein (CALM) primarily localizes in a diffuse pattern within the cytoplasm, whereas AF10 ..
  10. pmc Reduction of AP180 and CALM produces defects in synaptic vesicle size and density
    Ronald S Petralia
    Advanced Imaging Core, NIDCD NIH, Bethesda, MD 20892, USA
    Neuromolecular Med 15:49-60. 2013
    Clathrin assembly proteins AP180 and CALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse...
  11. doi Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase
    Kunihiko Kanatsu
    1 Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan 2
    Nat Commun 5:3386. 2014
    ..Recently, a single-nucleotide polymorphism in phosphatidylinositol binding clathrin assembly protein (PICALM/CALM) gene, which encodes a protein implicated in the clathrin-mediated ..
  12. pmc Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology
    Yuichi Ishikawa
    Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute of the City of Hope, Duarte, CA, USA Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Japan
    Haematologica 100:439-51. 2015
    ..b>PICALM, which encodes the clathrin adaptor protein PICALM, was originally identified as a component of the CALM/AF10 ..
  13. pmc Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance
    Zhen Zhao
    Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Nat Neurosci 18:978-87. 2015
    b>PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid-β (Aβ) pathology and cognitive impairment...
  14. pmc Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins
    Niclas Gimber
    Leibniz Institut für Molekulare Pharmakologie FMP and Freie Universität Berlin, Department of Molecular Pharmacology and Cell Biology, Robert Roessle Straße 10, 13125 Berlin, Germany
    Nat Commun 6:8392. 2015
    ..These data suggest that diffusion, and axonal escape of newly exocytosed vesicle proteins, are counteracted by the clathrin-based endocytic machinery together with a presynaptic diffusion barrier. ..
  15. doi Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo
    Kunihiko Kanatsu
    Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Hum Mol Genet 25:3988-3997. 2016
    ..AD patients have identified the endocytosis-related phosphatidylinositol-binding clathrin assembly protein (PICALM) gene as a genetic risk factor for AD...
  16. pmc The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice
    A Stoddart
    Department of Medicine, Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
    Oncogene 31:494-506. 2012
    The PICALM (CALM) gene, whose product is involved in clathrin-mediated endocytosis, has been identified in two recurring chromosomal translocations, involving either MLL or MLLT10 (AF10)...
  17. pmc Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis
    Qingli Xiao
    Hope Center for Neurological Disorders and Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:21279-89. 2012
    ..single nucleotide polymorphisms (SNPs) in the phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) gene were significantly associated with Alzheimer disease, suggesting a role in APP endocytosis and Aβ ..
  18. pmc The PICALM protein plays a key role in iron homeostasis and cell proliferation
    Paula B Scotland
    Division of Pediatric Hematology Oncology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS ONE 7:e44252. 2012
    The ubiquitously expressed phosphatidylinositol binding clathrin assembly (PICALM) protein associates with the plasma membrane, binds clathrin, and plays a role in clathrin-mediated endocytosis...
  19. pmc The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs
    Jenny Schlesinger
    Group Cardiovascular Genetics, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    PLoS Genet 7:e1001313. 2011
    ..This opens a new perspective to understand heart development and the complexity cardiovascular disorders...
  20. pmc A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis
    E M Rinchik
    Biology Division, Oak Ridge National Laboratory, TN 37831 8077
    Proc Natl Acad Sci U S A 87:896-900. 1990
    ..It is also yielding additional mutations useful in dissecting the functional and molecular complexity of this segment of chromosome 7...
  21. pmc Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development
    Kristopher R Schwab
    Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    BMC Biol 5:15. 2007
    ..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
  22. pmc N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutations
    E M Rinchik
    Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 8077, USA
    Genetics 152:373-83. 1999
    ..g., locus mutability, failure to saturate, number of gametes to screen, allelic series) of concern when application of chemical mutagenesis screens to megabase regions of the mouse genome is considered...
  23. ncbi Physical localization of eed: a region of mouse chromosome 7 required for gastrulation
    B C Holdener
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
    Genomics 27:447-56. 1995
    ..The second, l7Rn6, is required for survival after birth. fit1, a third locus identified by chemical mutagenesis, maps distal to the eed interval and is also required for ..

Research Grants1

  1. Mutagenesis of the Mammalian Imprinting Process(es)
    Eugene Rinchik; Fiscal Year: 2002
    ..abstract_text> ..