Genomes and Genes
Gene Symbol: Picalm
Description: phosphatidylinositol binding clathrin assembly protein
Alias: CALM, CLTH, PAP180, fit-1, fit1, mKIAA4114, phosphatidylinositol-binding clathrin assembly protein, clathrin assembly lymphoid myeloid leukemia
- The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouseJulia Grizenkova
MRC Prion Unit and Department of Neurodegenerative Diseases, UCL Institute of Neurology, University College, London, United Kingdom
PLoS ONE 5:e15019. 2010..Because of the increasing overlap described between prion and Alzheimer's diseases we also chose Clu, Picalm and Cr1, which were identified as part of Alzheimer's disease GWAS...
- Genetic and physical mapping of the fitness 1 (fit1) locus within the Fes-Hbb region of mouse chromosome 7M D Potter
University of Tennessee Oak Ridge Graduate School of Biomedical Sciences 37831 8077, USA
Mamm Genome 6:70-5. 1995Mutations at the fit1 locus affect normal pre- and post-natal development by retarding growth and reducing viability...
- Mutations in the murine fitness 1 gene result in defective hematopoiesisM D Potter
University of Tennessee Oak Ridge Graduate School of Biomedical Sciences, and the Biology Division of the Oak Ridge National Laboratory, 37831 8077, USA
Blood 90:1850-7. 1997..We report here that fit1 mutants are anemic, display numerous peripheral blood defects, and are deficient in early hematopoietic progenitor ..
- The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in miceMai Suzuki
Department of Biological Science, Graduate School of Humanities and Sciences, Nara Women s University, Nara, Japan
PLoS ONE 7:e31854. 2012b>Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, which results from the chromosomal ..
- Radiographic, histologic, and cytologic lesions associated with mutations in the fitness1(4226SB) locus of miceA E Schultze
Department of Pathology, The University of Tennessee, Knoxville 37901 1071, USA
Lab Anim Sci 49:260-8. 1999..Previous investigation of fitness1(4226SB) mice revealed growth retardation and microcytic, hypochromic anemia with functional iron deficiency. Serum biochemical analysis suggested protein-losing enteropathy and liver dysfunction...
- Mutations in the clathrin-assembly gene Picalm are responsible for the hematopoietic and iron metabolism abnormalities in fit1 miceMitchell L Klebig
Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA
Proc Natl Acad Sci U S A 100:8360-5. 2003..point mutations in the mouse ortholog of the human phosphatidylinositol-binding clathrin assembly protein (PICALM) gene, whose product is involved in clathrin-mediated endocytosis...
- Evidence for CALM in directing VAMP2 traffickingAsaff Harel
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
Traffic 9:417-29. 2008b>Clathrin assembly lymphoid myeloid leukemia protein (CALM) is a clathrin assembly protein with a domain structure similar to the neuron-specific assembly protein AP180...
- Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neuronsIttai Bushlin
Laboratory of Neurosciences, National Institute on Aging National Institutes of Health, Baltimore, Maryland 21224, USA
J Neurosci 28:10257-71. 2008..The clathrin assembly proteins AP180 and CALM (clathrin assembly lymphoid myeloid protein) are known to be involved in clathrin-mediated endocytosis, but their ..
- Nuclear export signal within CALM is necessary for CALM-AF10-induced leukemiaMai Suzuki
Division of Hematological Malignancy, National Cancer Center Research Institute, Tokyo, Japan
Cancer Sci 105:315-23. 2014..Wild-type clathrin assembly lymphoid myeloid leukemia protein (CALM) primarily localizes in a diffuse pattern within the cytoplasm, whereas AF10 ..
- Reduction of AP180 and CALM produces defects in synaptic vesicle size and densityRonald S Petralia
Advanced Imaging Core, NIDCD NIH, Bethesda, MD 20892, USA
Neuromolecular Med 15:49-60. 2013Clathrin assembly proteins AP180 and CALM regulate the assembly of clathrin-coated vesicles (CCVs), which mediate diverse intracellular trafficking processes, including synaptic vesicle (SV) recycling at the synapse...
- Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretaseKunihiko Kanatsu
1 Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan 2
Nat Commun 5:3386. 2014..Recently, a single-nucleotide polymorphism in phosphatidylinositol binding clathrin assembly protein (PICALM/CALM) gene, which encodes a protein implicated in the clathrin-mediated ..
- Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiologyYuichi Ishikawa
Division of Hematopoietic Stem Cell and Leukemia Research, Beckman Research Institute of the City of Hope, Duarte, CA, USA Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Japan
Haematologica 100:439-51. 2015..b>PICALM, which encodes the clathrin adaptor protein PICALM, was originally identified as a component of the CALM/AF10 ..
- Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearanceZhen Zhao
Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Nat Neurosci 18:978-87. 2015b>PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). We found that reduced expression of PICALM in AD and murine brain endothelium correlated with amyloid-β (Aβ) pathology and cognitive impairment...
- Diffusional spread and confinement of newly exocytosed synaptic vesicle proteinsNiclas Gimber
Leibniz Institut für Molekulare Pharmakologie FMP and Freie Universität Berlin, Department of Molecular Pharmacology and Cell Biology, Robert Roessle Straße 10, 13125 Berlin, Germany
Nat Commun 6:8392. 2015..These data suggest that diffusion, and axonal escape of newly exocytosed vesicle proteins, are counteracted by the clathrin-based endocytic machinery together with a presynaptic diffusion barrier. ..
- Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivoKunihiko Kanatsu
Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
Hum Mol Genet 25:3988-3997. 2016..AD patients have identified the endocytosis-related phosphatidylinositol-binding clathrin assembly protein (PICALM) gene as a genetic risk factor for AD...
- The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in miceA Stoddart
Department of Medicine, Section of Hematology Oncology, University of Chicago, Chicago, IL 60637, USA
Oncogene 31:494-506. 2012The PICALM (CALM) gene, whose product is involved in clathrin-mediated endocytosis, has been identified in two recurring chromosomal translocations, involving either MLL or MLLT10 (AF10)...
- Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesisQingli Xiao
Hope Center for Neurological Disorders and Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Biol Chem 287:21279-89. 2012..single nucleotide polymorphisms (SNPs) in the phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) gene were significantly associated with Alzheimer disease, suggesting a role in APP endocytosis and Aβ ..
- The PICALM protein plays a key role in iron homeostasis and cell proliferationPaula B Scotland
Division of Pediatric Hematology Oncology, Duke University Medical Center, Durham, North Carolina, USA
PLoS ONE 7:e44252. 2012The ubiquitously expressed phosphatidylinositol binding clathrin assembly (PICALM) protein associates with the plasma membrane, binds clathrin, and plays a role in clathrin-mediated endocytosis...
- The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAsJenny Schlesinger
Group Cardiovascular Genetics, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
PLoS Genet 7:e1001313. 2011..This opens a new perspective to understand heart development and the complexity cardiovascular disorders...
- A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesisE M Rinchik
Biology Division, Oak Ridge National Laboratory, TN 37831 8077
Proc Natl Acad Sci U S A 87:896-900. 1990..It is also yielding additional mutations useful in dissecting the functional and molecular complexity of this segment of chromosome 7...
- Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney developmentKristopher R Schwab
Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
BMC Biol 5:15. 2007..To better understand the functions of Pygopus-mediated canonical Wnt signaling in kidney development, targeted mutations were made in the two mammalian orthologs, Pygo1 and Pygo2...
- N-ethyl-N-nitrosourea mutagenesis of a 6- to 11-cM subregion of the Fah-Hbb interval of mouse chromosome 7: Completed testing of 4557 gametes and deletion mapping and complementation analysis of 31 mutationsE M Rinchik
Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831 8077, USA
Genetics 152:373-83. 1999..g., locus mutability, failure to saturate, number of gametes to screen, allelic series) of concern when application of chemical mutagenesis screens to megabase regions of the mouse genome is considered...
- Physical localization of eed: a region of mouse chromosome 7 required for gastrulationB C Holdener
Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
Genomics 27:447-56. 1995..The second, l7Rn6, is required for survival after birth. fit1, a third locus identified by chemical mutagenesis, maps distal to the eed interval and is also required for ..
- Mutagenesis of the Mammalian Imprinting Process(es)Eugene Rinchik; Fiscal Year: 2002..abstract_text> ..