Phb2

Summary

Gene Symbol: Phb2
Description: prohibitin 2
Alias: AU044498, BAP, Bap37, Bcap37, REA, prohibitin-2, B-cell receptor-associated protein 37, B-cell receptor-associated protein BAP37, phb2, repressor of estrogen receptor activity
Species: mouse

Top Publications

  1. ncbi Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence
    P J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Exp Cell Res 265:262-73. 2001
  2. pmc Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration
    Carsten Merkwirth
    Institute for Genetics, University of Cologne, Cologne, Germany
    PLoS Genet 8:e1003021. 2012
  3. pmc Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo
    Seong Eun Park
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Ave, Urbana, IL 61801 3704, USA
    Mol Cell Biol 25:1989-99. 2005
  4. pmc The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein
    M Terashima
    Max Planck Institut für Immunobiologie, Freiburg, Germany
    EMBO J 13:3782-92. 1994
  5. pmc A repressive role for prohibitin in estrogen signaling
    Bin He
    Department of Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Endocrinol 22:344-60. 2008
  6. pmc Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria
    Carsten Merkwirth
    Institute for Genetics, Centre for Molecular Medicine, University of Cologne, 50674 Cologne, Germany
    Genes Dev 22:476-88. 2008
  7. doi CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription
    Luguo Sun
    Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
    Cell Signal 23:1686-90. 2011
  8. doi The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells
    Olivier R Baris
    Center for Physiology and Pathophysiology, Institute for Vegetative Physiology, University of Cologne, Cologne, Germany
    Stem Cells 29:1459-68. 2011
  9. pmc Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination
    Y Poitelon
    Hunter James Kelly Research Institute, Department Biochemistry, University at Buffalo, Buffalo, New York 14203, USA
    Nat Commun 6:8303. 2015
  10. pmc Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development
    Sachin Supale
    Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, Geneva, Switzerland
    Diabetes 62:3488-99. 2013

Scientific Experts

  • P J Coates
  • Carsten Merkwirth
  • Thomas Langer
  • Benita S Katzenellenbogen
  • Yuechao Zhao
  • Anne Korwitz
  • Sunghee Park
  • Christina Ising
  • BERT W O'MALLEY
  • Lan Liao
  • Jianming Xu
  • Ricarda Richter-Dennerlein
  • Elena I Rugarli
  • Milan K Bagchi
  • Luguo Sun
  • Seong Eun Park
  • Olivier R Baris
  • Yuanyuan Li
  • Henning Hagmann
  • Sybille Koehler
  • Bernhard Schermer
  • Wilhelm Bloch
  • Francesca Fabretti
  • Sebastian Brähler
  • Thomas Benzing
  • Christine E Kurschat
  • Martin Höhne
  • Y Poitelon
  • Cristina Moncunill-Massaguer
  • Rong Yi Chen
  • Robert N Taylor
  • Megumi Kowno
  • Kun Wang
  • Rudolf J Wiesner
  • Christopher R Lucas
  • Sachin Supale
  • Hajime Yurugi
  • Dong Liu
  • Sangyeon Yoon
  • Sascha Dargazanli
  • Takashi Tatsuta
  • John P Lydon
  • Francesco J DeMayo
  • J M P Pabona
  • Gang Cao
  • Bin He
  • Karina Umanskaya
  • Paola Mussi
  • Vladislav Kurtev
  • Simon E Tröder
  • Wei Sun
  • Liyun Zou
  • Puneet Bharill
  • Dontscho Kerjaschki
  • Christina Schroeter
  • Roman U Müller
  • Sibylle Brinkkoetter
  • Yuzhang Wu
  • Ye Kuang
  • Hengning Lian
  • Regina Lin
  • Carlos Lopez-Otin
  • Haiying Ran
  • Ying Wan
  • Yu Wang
  • Quanfang Wei
  • John A Katzenellenbogen
  • Liting Wang
  • Yiru Chen
  • Wei Huang
  • Qingzhu Jia
  • Pedro M Quirós
  • Xiangyu Tang
  • Elizabeth Wong
  • Liqun Zhang
  • Li Ma
  • Qingshan Ni
  • Lizhang Tang
  • Qi jing Li
  • Hans Georg Sprenger
  • Yi Yang
  • Siqi Liu
  • Vicky Y Lin
  • Paul T Brinkkoetter
  • Claudia Mariela Palmeri
  • Rodolfo Lavilla
  • Paul Thomas Brinkkoetter
  • Helena Pomares
  • Sara Preciado
  • Zongbing You

Detail Information

Publications34

  1. ncbi Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence
    P J Coates
    Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Exp Cell Res 265:262-73. 2001
    The two prohibitin proteins, Phb1p and Phb2p(BAP37), have been ascribed various functions, including cell cycle regulation, apoptosis, assembly of mitochondrial respiratory chain enzymes, and aging...
  2. pmc Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration
    Carsten Merkwirth
    Institute for Genetics, University of Cologne, Cologne, Germany
    PLoS Genet 8:e1003021. 2012
    ..Prohibitins form large ring complexes in the inner membrane that are composed of PHB1 and PHB2 subunits and are thought to function as membrane scaffolds...
  3. pmc Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo
    Seong Eun Park
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Ave, Urbana, IL 61801 3704, USA
    Mol Cell Biol 25:1989-99. 2005
    We previously identified a coregulator, repressor of estrogen receptor activity (REA), that directly interacts with estrogen receptor (ER) and represses ER transcriptional activity...
  4. pmc The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein
    M Terashima
    Max Planck Institut für Immunobiologie, Freiburg, Germany
    EMBO J 13:3782-92. 1994
    ..p37 is highly homologous to p32. Since prohibitin was identified as an inhibitor of cell proliferation, its association with mIgM, but not mIgD, could explain the different biological events elicited after engagement of each receptor...
  5. pmc A repressive role for prohibitin in estrogen signaling
    Bin He
    Department of Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Endocrinol 22:344-60. 2008
    ..We demonstrate that PHB interacts with the repressor of estrogen receptor activity (REA), a protein related to PHB, to form heteromers and enhance the protein stability of both ..
  6. pmc Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria
    Carsten Merkwirth
    Institute for Genetics, Centre for Molecular Medicine, University of Cologne, 50674 Cologne, Germany
    Genes Dev 22:476-88. 2008
    ..Large assemblies of PHB1 and PHB2 subunits are localized in the inner membrane of mitochondria, but various roles in other cellular compartments have ..
  7. doi CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription
    Luguo Sun
    Institute of Genetics and Cytology, Northeast Normal University, Changchun, China
    Cell Signal 23:1686-90. 2011
    b>Prohibitin 2 (PHB2) is an evolutionarily conserved and ubiquitously expressed multifunctional protein which is present in various cellular compartments including the nucleus...
  8. doi The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells
    Olivier R Baris
    Center for Physiology and Pathophysiology, Institute for Vegetative Physiology, University of Cologne, Cologne, Germany
    Stem Cells 29:1459-68. 2011
    ..In conclusion, we here provide unequivocal evidence that EPSCs, and probably tissue stem cells in general, are independent of the mitochondrial respiratory chain, but still require a functional dynamic mitochondrial compartment...
  9. pmc Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination
    Y Poitelon
    Hunter James Kelly Research Institute, Department Biochemistry, University at Buffalo, Buffalo, New York 14203, USA
    Nat Commun 6:8303. 2015
    ..We thus validate a novel method to model morphogenesis and juxtacrine signalling, provide insights into the molecular organization of the axo-glial contact, and identify a novel class of molecules in myelination. ..
  10. pmc Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development
    Sachin Supale
    Department of Cell Physiology and Metabolism, University of Geneva Medical Centre, Geneva, Switzerland
    Diabetes 62:3488-99. 2013
    ..Ablation of Phb2 in mouse β-cells sequentially resulted in impairment of mitochondrial function and insulin secretion, loss of β-..
  11. pmc Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria
    Megumi Kowno
    Graduate School of Life and Environmental Sciences, The University of Tsukuba, Tsukuba, Ibaraki, Japan
    PLoS ONE 9:e81552. 2014
    ..Recent studies also suggested the significant contribution of mitochondria on the regulation of pluripotent stem cells. However, the molecules involved in these regulations are still unknown...
  12. doi CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation
    Kun Wang
    1 Division of Cardiovascular Research, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 2
    Nat Commun 5:3596. 2014
    ..cardiac apoptosis-related lncRNA (CARL), can suppress mitochondrial fission and apoptosis by targeting miR-539 and PHB2. The results show that PHB2 is able to inhibit mitochondrial fission and apoptosis...
  13. doi DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling
    Ricarda Richter-Dennerlein
    Institute for Genetics, University of Cologne, 50931 Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD, University of Cologne, 50931 Cologne, Germany
    Cell Metab 20:158-71. 2014
    ..Here, we have defined the interactome of PHB2 in mitochondria and identified DNAJC19, mutated in dilated cardiomyopathy with ataxia, as binding partner of PHB ..
  14. doi Expression of prohibitins on the surface of activated T cells
    Hajime Yurugi
    Department of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo Motoyama, Kitaku, Kyoto 603 8555, Japan
    Biochem Biophys Res Commun 420:275-80. 2012
    ..These results suggest that prohibitins expressed on the surface of activated T cells are involved in the T cell receptor-mediated signaling cascade...
  15. pmc Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure
    Christina Ising
    Department II of Internal Medicine and Center for Molecular Medicine Cologne CMMC, University of Cologne, Cologne, Germany
    EMBO Mol Med 7:275-87. 2015
    ..essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin-2 (PHB2) at the mitochondrial inner membrane...
  16. pmc Estradiol inhibits Th17 cell differentiation through inhibition of RORγT transcription by recruiting the ERα/REA complex to estrogen response elements of the RORγT promoter
    Rong Yi Chen
    Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, China Department of Structural and Cellular Biology, Tulane University Health Sciences Center, New Orleans, LA 70112 and
    J Immunol 194:4019-28. 2015
    ..Estradiol activated estrogen receptor (ER)α to recruit repressor of estrogen receptor activity (REA) and form the ERα/REA complex...
  17. pmc A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation
    Cristina Moncunill-Massaguer
    Departament de Ciències Fisiològiques II, Universitat de Barcelona Institut d Investigació Biomèdica de Bellvitge IDIBELL, L Hospitalet de Llobregat, Catalunya, Spain
    Oncotarget 6:41750-65. 2015
    ..Finally, Noxa(-/-)/Bim(-/-) MEFs and NOXA-downregulated HeLa cells were resistant to fluorizoline-induced apoptosis. All together, these findings show that fluorizoline requires PHBs to execute the mitochondrial apoptotic pathway...
  18. pmc Multiple Beneficial Roles of Repressor of Estrogen Receptor Activity (REA) in Suppressing the Progression of Endometriosis
    Yuechao Zhao
    Departments of Molecular and Integrative Physiology Y Z, Y C, M K B, B S K and Chemistry J A K, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 Department of Gynecology and Obstetrics Y K, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China and Department of Obstetrics and Gynecology R N T, Wake Forest School of Medicine, Winston Salem, North Carolina 27157
    Endocrinology 157:900-12. 2016
    ..host mice with partial genetic deletion of the ER coregulator, repressor of ER activity (REA) (also known as prohibitin 2), to investigate roles of REA in the contributions of donor uterine tissue and host cell influences on ..
  19. pmc Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria
    Anne Korwitz
    Institute of Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, 50931 Cologne, Germany
    J Cell Biol 212:157-66. 2016
    ..Thus, long OPA1 forms can promote neuronal survival independently of cristae shape, whereas stress-induced OMA1 activation and OPA1 cleavage limit mitochondrial fusion and promote neuronal death. ..
  20. doi Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment
    Yuanyuan Li
    Biomedical Analysis Center, Third Military Medical University, Chongqing 400038, China Chongqing Key Laboratory of Cytomics, Chongqing 400038, China
    Immunity 44:422-37. 2016
    ..monocytogenes. Mechanistically, Rab32 formed a persistent complex with two interacting proteins, PHB and PHB2, to encompass bacteria both during early phagosome formation and after L...
  21. ncbi Truncated estrogen receptor product-1 stimulates estrogen receptor alpha transcriptional activity by titration of repressor proteins
    Vicky Y Lin
    Department of Pharmacology, Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:38125-31. 2003
    ..We found that repressor of estrogen receptor activity (REA), originally isolated from human breast cancer cells, is present in mouse pituitary ..
  22. doi Prohibitin-2 Depletion Unravels Extra-Mitochondrial Functions at the Kidney Filtration Barrier
    Christina Ising
    Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany Department of Neurology, Hope Center for Neurological Disorders, Charles F and Joanne Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri
    Am J Pathol 186:1128-39. 2016
    ..essential for maintenance of mitochondrial function and requires the prohibitin ring complex subunit prohibitin-2 (PHB2) at the mitochondrial inner membrane...
  23. pmc Mitochondrial dysfunction and adipogenic reduction by prohibitin silencing in 3T3-L1 cells
    Dong Liu
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 7:e34315. 2012
    ..Prohibitins (PHBs), comprised of two evolutionarily conserved proteins, prohibitin-1 (PHB1) and prohibitin-2 (PHB2), are present in a high molecular-weight complex in the inner membrane of mitochondria...
  24. pmc The coregulator, repressor of estrogen receptor activity (REA), is a crucial regulator of the timing and magnitude of uterine decidualization
    Yuechao Zhao
    Department of Molecular and Integrative Physiology, University of Illinois and College of Medicine at Urbana Champaign, Urbana, IL 61801, USA
    Endocrinology 154:1349-60. 2013
    ..In this study, we have established a key role for the coregulator, repressor of estrogen receptor activity (REA), in the decidualization of human endometrial stromal cells (hESCs) in vitro and of the ..
  25. pmc Prohibitins and the cytoplasmic domain of CD86 cooperate to mediate CD86 signaling in B lymphocytes
    Christopher R Lucas
    Integrated Biomedical Science Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    J Immunol 190:723-36. 2013
    ..identification approach, we show that the tyrosine-containing transmembrane adaptor proteins prohibitin (Phb)1 and Phb2 bind to CD86...
  26. pmc Uterine development and fertility are dependent on gene dosage of the nuclear receptor coregulator REA
    Sunghee Park
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Endocrinology 153:3982-94. 2012
    ..Because conventional genetic deletion of the coregulator, repressor of estrogen receptor activity (REA), was embryonic lethal, we here study REA conditional knockout mice generated by cre-loxP ..
  27. ncbi Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation
    Luguo Sun
    Department of Biochemistry, Hong Kong University of Science and Technology, Hong Kong, China
    J Cell Sci 117:3021-9. 2004
    In a yeast two-hybrid screen using the full-length Akt as bait, we found that prohibitin 2 (PHB2) specifically interacts with Akt...
  28. pmc Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice
    Sunghee Park
    Department of Molecular and Integrative Physiology, University of Illinois, 524 Burrill Hall, 407 South Goodwin Avenue, Urbana, Illinois 61801 3704, USA
    Endocrinology 152:4336-49. 2011
    ..we have investigated the consequences of reduction or loss of function of the coregulator repressor of ER activity (REA) by conditionally deleting one allele or both alleles of the REA gene at different stages of mammary gland ..
  29. pmc Regulation of the epithelial Mg2+ channel TRPM6 by estrogen and the associated repressor protein of estrogen receptor activity (REA)
    Gang Cao
    Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Institute for Genetic and Metabolic Disease, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 284:14788-95. 2009
    ..Here, we identified the repressor of estrogen receptor activity (REA) as an interacting protein of TRPM6 that binds to the 6(th), 7(th), and 8(th) beta-sheets in ..
  30. pmc Nuclear receptor co-regulator Krüppel-like factor 9 and prohibitin 2 expression in estrogen-induced epithelial cell proliferation in the mouse uterus
    J M P Pabona
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    J Endocrinol 200:63-73. 2009
    ..pregnancy uteri of WT mice, the temporal pattern of Klf9 transcript levels was inversely associated with that of Phb2. Deletion of Klf9 up-regulated uterine Phb2 expression and increased PHB2 nuclear localization in endometrial ST ..
  31. pmc Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor
    Karina Umanskaya
    Department of Medicine, Division of Hematology Oncology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1178, New York, NY 10029, USA
    Mol Cell Biol 27:7615-22. 2007
    ..We found that Skp2B interacts with the repressor of estrogen receptor activity (REA) and that overexpression of Skp2B leads to a reduction in REA levels...
  32. pmc Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland
    Paola Mussi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:16716-21. 2006
    ..The repressor of ER activity (REA) is an ER-interactive protein that counterbalances estrogen-induced ER transcriptional activity...
  33. ncbi Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases
    Vladislav Kurtev
    Institute of Medical Biochemistry, Max F Perutz Laboratories, Medical University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
    J Biol Chem 279:24834-43. 2004
    ..Using the yeast two-hybrid system, we isolated the repressor of estrogen receptor activity (REA) as a novel HDAC1-associated protein...
  34. ncbi Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6
    M A Ansari-Lari
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 8:29-40. 1998
    ....