Pgd

Summary

Gene Symbol: Pgd
Description: phosphogluconate dehydrogenase
Alias: 0610042A05Rik, AU019875, C78335, 6-phosphogluconate dehydrogenase, decarboxylating
Species: mouse

Top Publications

  1. pmc Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation
    Lianjun Zhang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 112:4003-8. 2015
  2. doi Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
    Vikas P Sukhatme
    Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    FEBS Lett 586:2389-95. 2012
  3. ncbi Genetic mapping in mammals: chromosome map of domestic cat
    S J O'Brien
    Science 216:257-65. 1982
  4. ncbi Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c
    Ho Kyung Rho
    Department of Biological Sciences, Seoul National University, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 332:288-96. 2005
  5. ncbi Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse
    Robert A White
    Children s Mercy Hospitals and Clinics, Pediatric Research Center, 4th Floor, 2401 Gillham Rd, Kansas City, MO 64108, USA
    Blood 104:1511-8. 2004
  6. pmc A comparative gene map of the horse (Equus caballus)
    A R Caetano
    Veterinary Genetics Laboratory, University of California Davis, Davis, California 95616 8744, USA
    Genome Res 9:1239-49. 1999
  7. ncbi In situ glucose-6-phosphate dehydrogenase activity during development of pre-implantation mouse embryos
    G G De Schepper
    Institute of Human Genetics, Academic Medical Center, Amsterdam, The Netherlands
    Histochem J 25:299-303. 1993
  8. ncbi Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6
    P A Clamp
    Department of Animal Sciences, University of Illinois, Urbana Champaign
    Genomics 17:324-9. 1993
  9. ncbi Syntenic assignment of human chromosome 1 homologous loci in the bovine
    D S Threadgill
    Department of Veterinary Pathobiology, Texas A and M University, College Station 77843
    Genomics 22:626-30. 1994
  10. ncbi The bovine B and C blood group systems are not likely to be the orthologues of human RH: an interesting twist in the comparative map
    H A Lewin
    Department of Animal Sciences, University of Illinois, Urbana 61801
    Anim Genet 25:13-8. 1994

Scientific Experts

  • Robert A White
  • Lianjun Zhang
  • Vikas P Sukhatme
  • Ho Kyung Rho
  • XiuHong Cui
  • Vicki Huff
  • Fei Gao
  • Yan Qin
  • Yanbo Wang
  • Lin Yang
  • Min Chen
  • Yaqiong Li
  • Qing Wen
  • Yaqing Wang
  • Barden Chan
  • A R Caetano
  • Jae Bum Kim
  • Jiyoung Park
  • Jung Hee Suh
  • S J O'Brien
  • J P Stoye
  • A T Bowling
  • Y L Shiue
  • J D Murray
  • L A Lyons
  • T F Laughlin
  • H A Lewin
  • D S Threadgill
  • J E Beever
  • P A Lalley
  • P A Clamp
  • G G De Schepper
  • S Jeremiah
  • S Best
  • N Kaushik
  • D W Threadgill
  • H W Davey
  • J A Weiss
  • J E Womack
  • Y Da
  • D B Faulkner
  • N Zhang
  • Y D Moll
  • U Francke
  • A G Wildeman
  • H C Hines
  • A Westerveld
  • C Vander Perk
  • L B Schook
  • J Oosting
  • C J Van Noorden
  • E Atac
  • J D Minna
  • D Shalhevet
  • F H Ruddle
  • R Feltes
  • C Kozak
  • H H Krog
  • S L Naylor
  • R L Stallings
  • H Satoh
  • V M Chapman
  • C A Kozak
  • M Roberts
  • W D Dawson
  • A Y Sakaguchi
  • M J Siciliano
  • H M Goodman
  • W Moss
  • J B Shaffer
  • M Wysocka
  • E Nichols
  • P Kisielow
  • W W Chin
  • M R Felder
  • C Radzikowski
  • K H Grzeschik
  • M C Yoshida
  • J Ivy
  • W G Nash
  • L L Huang

Detail Information

Publications23

  1. pmc Reprogramming of Sertoli cells to fetal-like Leydig cells by Wt1 ablation
    Lianjun Zhang
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Science, Beijing 100101, China University of Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 112:4003-8. 2015
    ..This study thus provides a novel concept for somatic cell fate determination in testis development that may also represent an etiology of male infertility in human patients. ..
  2. doi Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
    Vikas P Sukhatme
    Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    FEBS Lett 586:2389-95. 2012
    ..Therefore, 6PGD inhibition may provide a novel strategy to treat glycolyic tumors such as lung cancer...
  3. ncbi Genetic mapping in mammals: chromosome map of domestic cat
    S J O'Brien
    Science 216:257-65. 1982
    ..Many of these same linkage groups have not been conserved in the murine genome. The genetic and evolutionary implications of comparative mapping analysis among mammalian species are discussed...
  4. ncbi Transcriptional regulation of mouse 6-phosphogluconate dehydrogenase by ADD1/SREBP1c
    Ho Kyung Rho
    Department of Biological Sciences, Seoul National University, Seoul 151 742, Republic of Korea
    Biochem Biophys Res Commun 332:288-96. 2005
    ..Taken together, these data suggest that ADD1/SREBP1c is a key transcription factor for 6PGDH gene expression and would coordinate glucose metabolism and lipogenesis for energy homeostasis...
  5. ncbi Chromosomal localization, hematologic characterization, and iron metabolism of the hereditary erythroblastic anemia (hea) mutant mouse
    Robert A White
    Children s Mercy Hospitals and Clinics, Pediatric Research Center, 4th Floor, 2401 Gillham Rd, Kansas City, MO 64108, USA
    Blood 104:1511-8. 2004
    ..When this diet is removed there is reversion to anemia with concomitant loss of overloaded iron stores. We speculate that the hea/fsn gene is required for iron uptake into erythropoietic cells and for kidney iron reabsorption...
  6. pmc A comparative gene map of the horse (Equus caballus)
    A R Caetano
    Veterinary Genetics Laboratory, University of California Davis, Davis, California 95616 8744, USA
    Genome Res 9:1239-49. 1999
    ..The equine type I markers developed in this study provide an important resource for the future development of the horse linkage and physical genome maps...
  7. ncbi In situ glucose-6-phosphate dehydrogenase activity during development of pre-implantation mouse embryos
    G G De Schepper
    Institute of Human Genetics, Academic Medical Center, Amsterdam, The Netherlands
    Histochem J 25:299-303. 1993
    ..It is concluded that high activity of glucose-6-phosphate dehydrogenase in oocytes is needed for keeping oocytes viable, and for generation of NADPH which is important for the fertilization process...
  8. ncbi Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6
    P A Clamp
    Department of Animal Sciences, University of Illinois, Urbana Champaign
    Genomics 17:324-9. 1993
    ..phosphatase (ALPL), enolase 1-alpha (ENO1), glucose-phosphate isomerase (GPI), phosphogluconate dehydrogenase (PGD), and transforming growth factor beta 1 (TGFB1) in swine...
  9. ncbi Syntenic assignment of human chromosome 1 homologous loci in the bovine
    D S Threadgill
    Department of Veterinary Pathobiology, Texas A and M University, College Station 77843
    Genomics 22:626-30. 1994
    ..AT3, REN, CR2, and GNB1 mapped to BTA 16, PFKM to BTA 5, AMY1A and NRAS to BTA 3, FGR and FUCA1 to BTA 2, and ACTA1 to BTA 28...
  10. ncbi The bovine B and C blood group systems are not likely to be the orthologues of human RH: an interesting twist in the comparative map
    H A Lewin
    Department of Animal Sciences, University of Illinois, Urbana 61801
    Anim Genet 25:13-8. 1994
    ..using blood typing and restriction fragment length polymorphism (RFLP) analysis of four loci linked to RH on HSA1; PGD, FGR, ALPL and FUCA1. Four sires with a total of 255 half-sib offspring were used for the linkage analysis...
  11. ncbi Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse chromosome 4
    J P Stoye
    National Institute for Medical Research, Ridgeway, Mill Hill, London, UK
    Mamm Genome 6:31-6. 1995
    ..Three markers, Xmv9, Nppa, and Iap3rc11, were identified that showed no recombination with Fv1. By combining backcross and recombinant inbred strain data, we estimated that Xmv9 and Nppa must lie within 0.6 cM of one another and Fv1...
  12. ncbi Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7
    R L Stallings
    Somatic Cell Genet 7:683-98. 1981
    ..The assignments provide markers for the study of the genetic consequences of chromosomal rearrangements in Chinese hamster cell lines and support the concept of conservation of mammalian autosomal linkage groups...
  13. ncbi Genetic characterization of important mouse strains used in cancer research
    H H Krog
    Hereditas 87:201-4. 1977
  14. ncbi Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse
    S L Naylor
    Somatic Cell Genet 9:757-70. 1983
    ..In the mouse, the alpha subunit gene, detected by a mouse thyrotropin (TSH) alpha subunit probe, and the CG beta-like sequences (CG beta-LH beta), detected by the human CG beta cDNA probe, are on chromosomes 4 and 7, respectively...
  15. ncbi The Chinese hamster gene map. Assignment of four genes (DTS, PGM2, 6PGD, EnoI) to chromosome 2
    M Roberts
    Exp Cell Res 127:47-54. 1980
  16. ncbi Linkage relationships among eleven biochemical loci in Peromyscus
    W D Dawson
    Biochem Genet 21:1101-14. 1983
    ..These and other known linkage relationships in Peromyscus correspond closely to those of the house mouse, Mus musculus. The available evidence in Peromyscus further supports the concept of linkage conservation by natural selection...
  17. ncbi Gene mapping in the Chinese hamster and conservation of syntenic groups and Q-band homologies between Chinese hamster and mouse chromosomes
    H Satoh
    Cytogenet Cell Genet 39:285-91. 1985
    ..loci, three genes, HK1, PEPC, and SORD, were newly assigned to chromosomes 1, 5, and 6, respectively, while ENO1, PGD, and PGM1 were assigned to the long arm of chromosome 2, in the segment 2q113----qter...
  18. ncbi Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome
    C Kozak
    Somatic Cell Genet 1:371-82. 1975
    ..All other isozymes examined segregated independently of one another...
  19. ncbi 6-Phosphogluconate dehydrogenase (PGD) genetics in the mouse: linkage with metabolically related enzyme loci
    V M Chapman
    Biochem Genet 13:849-56. 1975
    An electrophoretic polymorphism of 6-phosphogluconate dehydrogenase (PGD) has been observed in the subspecies Mus musculus musculus from northern Denmark. M. m...
  20. ncbi Conservation of autosomal gene synteny groups in mouse and man
    P A Lalley
    Nature 274:160-3. 1978
  21. pmc Homologous genes for enolase, phosphogluconate dehydrogenase, phosphoglucomutase, and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome 1p
    P A Lalley
    Proc Natl Acad Sci U S A 75:2382-6. 1978
    ..2.1.11, McKusick no. 17245), 6-phosphogluconate dehydrogenase [PGD; EC 1.1.1.44, McKusick no. 17220], phosphoglucomutase-2 (PGM-2; EC 2.7.5.1, McKusick no...
  22. ncbi Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids
    C A Kozak
    Somatic Cell Genet 3:121-33. 1977
  23. ncbi Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2
    U Francke
    Cytogenet Cell Genet 19:57-84. 1977
    ..confirm the assignments of 11 genes previously mapped by sexual genetics: Dip-1 and Id-1 to chromosome 1; Pgm-2 and Pgd to 4; Pgm-1 to 5; Gpi-1 to 7; Gr-1 to 8; Mpi-1 and Mod-1 to 9; Np-1 and Es-10 to 14...