Pepd

Summary

Gene Symbol: Pepd
Description: peptidase D
Alias: Pep-4, Pep4, dal, xaa-Pro dipeptidase, X-pro dipeptidase, imidodipeptidase, peptidase 4, prolidase, proline dipeptidase
Species: mouse

Top Publications

  1. doi Genetic and phenotypic studies of the dark-like mutant mouse
    Christina D Cota
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Genesis 46:562-73. 2008
  2. doi Lack of prolidase causes a bone phenotype both in human and in mouse
    Roberta Besio
    Department of Molecular Medicine, University of Pavia, Pavia, Italy
    Bone 72:53-64. 2015
  3. pmc Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling
    Lu Yang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 288:2365-75. 2013
  4. ncbi Conservation of autosomal gene synteny groups in mouse and man
    P A Lalley
    Nature 274:160-3. 1978
  5. ncbi Comparative gene mapping in man and mouse: assignment of the genes for lactate dehydrogenase-A, peptidase-D, and isocitrate dehydrogenase-2 to mouse chromosome 7
    P A Lalley
    Cytogenet Cell Genet 22:577-80. 1978
  6. ncbi Chromosomal and regional localization of the genes for UMPH2, APRT, PEPD, PEPS, PSP, and PGP in mink: comparison with man and mouse
    S D Pack
    Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Department, Novosibirsk
    Cytogenet Cell Genet 50:127-31. 1989
  7. ncbi Gene mapping in the Chinese hamster and conservation of syntenic groups and Q-band homologies between Chinese hamster and mouse chromosomes
    H Satoh
    Cytogenet Cell Genet 39:285-91. 1985
  8. ncbi Electrophoretic heterogeneity of mouse erythrocyte peptidases
    W H Lewis
    Biochem Genet 3:493-8. 1969
  9. ncbi Human times mouse hybrid cells segregating mouse chromosomes and isozymes
    J D Minna
    Nature 252:401-4. 1974
  10. ncbi Genes for serum amyloid A proteins map to Chromosome 7 in the mouse
    B A Taylor
    Mol Gen Genet 195:491-9. 1984

Detail Information

Publications14

  1. doi Genetic and phenotypic studies of the dark-like mutant mouse
    Christina D Cota
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Genesis 46:562-73. 2008
    The dark-like (dal) mutant mouse has a pleiotropic phenotype that includes dark dorsal hairs and reproductive degeneration...
  2. doi Lack of prolidase causes a bone phenotype both in human and in mouse
    Roberta Besio
    Department of Molecular Medicine, University of Pavia, Pavia, Italy
    Bone 72:53-64. 2015
    ..In humans, prolidase is the only enzyme able to hydrolyze dipeptides containing these amino acids at their C-terminal end, thus being ..
  3. pmc Prolidase directly binds and activates epidermal growth factor receptor and stimulates downstream signaling
    Lu Yang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 288:2365-75. 2013
    b>Prolidase, also known as Xaa-Pro dipeptidase or peptidase D (PEPD), is a ubiquitously expressed cytosolic enzyme that hydrolyzes dipeptides with proline or hydroxyproline at the carboxyl terminus...
  4. ncbi Conservation of autosomal gene synteny groups in mouse and man
    P A Lalley
    Nature 274:160-3. 1978
  5. ncbi Comparative gene mapping in man and mouse: assignment of the genes for lactate dehydrogenase-A, peptidase-D, and isocitrate dehydrogenase-2 to mouse chromosome 7
    P A Lalley
    Cytogenet Cell Genet 22:577-80. 1978
  6. ncbi Chromosomal and regional localization of the genes for UMPH2, APRT, PEPD, PEPS, PSP, and PGP in mink: comparison with man and mouse
    S D Pack
    Institute of Cytology and Genetics, Academy of Sciences of the USSR, Siberian Department, Novosibirsk
    Cytogenet Cell Genet 50:127-31. 1989
    ..APRT), phosphoserine phosphatase (PSP), phosphoglycolate phosphatase (PGP), peptidases D (PEPD) and S (PEPS), as well as mink chromosomes, was investigated in a set of mink x mouse hybrid clones...
  7. ncbi Gene mapping in the Chinese hamster and conservation of syntenic groups and Q-band homologies between Chinese hamster and mouse chromosomes
    H Satoh
    Cytogenet Cell Genet 39:285-91. 1985
    ..were confirmed: ESD, NP, and PEPB on chromosome 1, ME1 and MPI on chromosome 4, AK1 on chromosome 6, and GPI and PEPD on chromosome 9...
  8. ncbi Electrophoretic heterogeneity of mouse erythrocyte peptidases
    W H Lewis
    Biochem Genet 3:493-8. 1969
  9. ncbi Human times mouse hybrid cells segregating mouse chromosomes and isozymes
    J D Minna
    Nature 252:401-4. 1974
  10. ncbi Genes for serum amyloid A proteins map to Chromosome 7 in the mouse
    B A Taylor
    Mol Gen Genet 195:491-9. 1984
    ..A survey of inbred strains revealed a single common Saa haplotype and eight rare haplotypes. The complex distribution of 14 different variants suggests that recombination may have played a role in haplotype evolution...
  11. ncbi Genetic variation for prolidase (PEP-4) in the mouse maps near the gene for glucosephosphate isomerase (GPI-1) on chromosome 7
    L C Skow
    Biochem Genet 19:695-700. 1981
    An inherited electrophoretic variant of prolidase (EC 3.4.13.9), also called peptidase 4 (PEP-4), has been discovered among inbred strains of mice...
  12. ncbi Cloning of mouse prolidase cDNA: predominant expression of prolidase mRNA in kidney
    T Ishii
    Department of Inherited Metabolic Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Biochim Biophys Acta 1308:15-6. 1996
    We cloned mouse prolidase cDNA from a mouse liver cDNA library. Homology to human prolidase is 83.2% at the nucleotide level and 87.2% at the amino acid level...
  13. ncbi Nitric oxide regulates prolidase activity by serine/threonine phosphorylation
    Arkadiusz Surazynski
    Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA
    J Cell Biochem 96:1086-94. 2005
    b>Prolidase [E.C. 3.4.13.9], a member of the matrix metalloproteinase (MMP) family, is a manganese-dependent cytosolic exopeptidase that cleaves imidodipeptides containing C-terminal proline or hydroxyproline...
  14. doi Developmental cardiac hypertrophy in a mouse model of prolidase deficiency
    SeungWoo Jung
    Department of Biomedical Sciences, Cornell University, Ithaca, New York
    Birth Defects Res A Clin Mol Teratol 91:204-17. 2011
    ..Most inherited forms result from mutations in genes encoding sarcomeric proteins...