Pecam1

Summary

Gene Symbol: Pecam1
Description: platelet/endothelial cell adhesion molecule 1
Alias: C85791, Cd31, PECAM-1, Pecam, platelet endothelial cell adhesion molecule
Species: mouse

Top Publications

  1. ncbi Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Nature 380:435-9. 1996
  2. ncbi Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    C Suri
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1171-80. 1996
  3. pmc HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    H E Ryan
    Department of Biology, University of California, San Diego, La Jolla, CA 92093 0366, USA
    EMBO J 17:3005-15. 1998
  4. doi Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Nature 454:656-60. 2008
  5. pmc Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    Chenghua Gu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 5:45-57. 2003
  6. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
  7. pmc Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
    Nicholas W Gale
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 101:15949-54. 2004
  8. pmc Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
  9. ncbi NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
    U Ozerdem
    The Burnham Institute, 10901 North Torrey Pines Road, San Diego, CA 92307, USA
    Dev Dyn 222:218-27. 2001
  10. doi The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
    Konstantin Gaengel
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Dev Cell 23:587-99. 2012

Research Grants

Detail Information

Publications201 found, 100 shown here

  1. ncbi Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Nature 380:435-9. 1996
    ....
  2. ncbi Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
    C Suri
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Cell 87:1171-80. 1996
    ..Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme...
  3. pmc HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    H E Ryan
    Department of Biology, University of California, San Diego, La Jolla, CA 92093 0366, USA
    EMBO J 17:3005-15. 1998
    ..These data demonstrate the essential role of HIF-1alpha in controlling both embryonic and tumorigenic responses to variations in microenvironmental oxygenation...
  4. doi Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Nature 454:656-60. 2008
    ..Our results implicate VEGFR-3 as a regulator of vascular network formation. Targeting VEGFR-3 may provide additional efficacy for anti-angiogenic therapies, especially towards vessels that are resistant to VEGF or VEGFR-2 inhibitors...
  5. pmc Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development
    Chenghua Gu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Dev Cell 5:45-57. 2003
    ..Therefore, Npn-1 is a multifunctional receptor that mediates the activities of structurally distinct ligands during development of the heart, vasculature, and nervous system...
  6. ncbi Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
    Marika J Karkkainen
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Haartman Institute and Helsinki University Hospital, Biomedicum Helsinki, University of Helsinki, PO Box 63, 00014 Helsinki, Finland
    Nat Immunol 5:74-80. 2004
    ..Our results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both Vegfc alleles are required for normal lymphatic development...
  7. pmc Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
    Nicholas W Gale
    Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Proc Natl Acad Sci U S A 101:15949-54. 2004
    ..In summary, Dll4 appears to be a major trigger of Notch receptor activities previously implicated in arterial and vascular development, and it may represent a new opportunity for pro- and anti-angiogenic therapies...
  8. pmc Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
    ..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4...
  9. ncbi NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis
    U Ozerdem
    The Burnham Institute, 10901 North Torrey Pines Road, San Diego, CA 92307, USA
    Dev Dyn 222:218-27. 2001
    ..Additional insight into these and other aspects of vascular morphogenesis should be possible through use of NG2 as a mural cell marker...
  10. doi The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2
    Konstantin Gaengel
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institutet, 17177 Stockholm, Sweden
    Dev Cell 23:587-99. 2012
    ..Our data suggest that S1PR1 signaling acts as a vascular-intrinsic stabilization mechanism, protecting developing blood vessels against aberrant angiogenic responses...
  11. pmc Mapping Wnt/beta-catenin signaling during mouse development and in colorectal tumors
    Silvia Maretto
    Histology and Embryology Section, Department of Histology, Microbiology, and Medical Biotechnology, University of Padua, 35131 Padua, Italy
    Proc Natl Acad Sci U S A 100:3299-304. 2003
    ..In summary, BAT-gal mice unveil the entire complexity of Wntbeta-catenin signaling in mammals and have broad application potentials for the identification of Wnt-responsive cell populations in development and disease...
  12. pmc Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells
    Yunfu Sun
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Dev Biol 304:286-96. 2007
    ..Our studies suggest a role for Isl1 in these distinct domains of expression within the heart...
  13. doi Sox18 induces development of the lymphatic vasculature in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia
    Nature 456:643-7. 2008
    ..Our findings demonstrate a critical role for Sox18 in developmental lymphangiogenesis, and suggest new avenues to investigate for therapeutic management of human lymphangiopathies...
  14. pmc Notch signaling is essential for vascular morphogenesis in mice
    L T Krebs
    The Jackson Laboratory, Bar Harbor, Maine 04609 USA
    Genes Dev 14:1343-52. 2000
    ....
  15. pmc Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
    Christiana Ruhrberg
    Endothelial Cell Biology Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 16:2684-98. 2002
    ..We conclude that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern...
  16. pmc A novel role for PECAM-1 (CD31) in regulating haematopoietic progenitor cell compartmentalization between the peripheral blood and bone marrow
    Ewan A Ross
    Rheumatology Research Group, MRC Centre for Immune Regulation, University of Birmingham, Birminham, United Kingdom
    PLoS ONE 3:e2338. 2008
    Although the expression of PECAM-1 (CD31) on vascular and haematopoietic cells within the bone marrow microenvironment has been recognized for some time, its physiological role within this niche remains unexplored...
  17. pmc Slug is a direct Notch target required for initiation of cardiac cushion cellularization
    Kyle Niessen
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada
    J Cell Biol 182:315-25. 2008
    ..Collectively, our data suggest that combined expression of Slug and Snail is required for EMT in cardiac cushion morphogenesis...
  18. pmc Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression
    Horace Delisser
    Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:18616-21. 2010
    ..Here we show that the TME, functioning in part through platelet endothelial cell adhesion molecule 1 (PECAM-1), drives advanced metastatic progression and is essential for progression through ..
  19. ncbi Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    G H Fong
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:66-70. 1995
    ..We suggest that the Flt-1 signalling pathway may regulate normal endothelial cell-cell or cell-matrix interactions during vascular development...
  20. ncbi Abnormal lymphatic vessel development in neuropilin 2 mutant mice
    Li Yuan
    INSERM U36, College de France, 11, place Marcelin Berthelot, 75005 Paris, France
    Development 129:4797-806. 2002
    ..Arteries, veins and larger, collecting lymphatic vessels developed normally, suggesting that neuropilin 2 is selectively required for the formation of small lymphatic vessels and capillaries...
  21. pmc The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching
    Steven Suchting
    Institut National de la Sante et de la Recherche Medicale, U833, 75005 Paris, France
    Proc Natl Acad Sci U S A 104:3225-30. 2007
    ..Taken together, these data reveal Dll4 as a negative regulator of vascular sprouting and vessel branching that is required for normal vascular network formation during development...
  22. pmc Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1
    Abigail Woodfin
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, William Harvey Research Institute, London, United Kingdom
    Blood 113:6246-57. 2009
    ..how intercellular adhesion molecule-2 (ICAM-2), junctional adhesion molecule-A (JAM-A), and platelet endothelial cell adhesion molecule (PECAM-1) mediate neutrophil transmigration in a stimulus-dependent manner (eg, as induced by ..
  23. pmc FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1
    Camilla Norrmen
    Molecular Cancer Biology Program, Biomedicum Helsinki, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
    J Cell Biol 185:439-57. 2009
    ..As damage to collecting vessels is a major cause of lymphatic dysfunction in humans, our results suggest that FOXC2 and NFATc1 are potential targets for therapeutic intervention...
  24. ncbi Prox1 function is required for the development of the murine lymphatic system
    J T Wigle
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell 98:769-78. 1999
    ..These findings suggest that Prox1 is a specific and required regulator of the development of the lymphatic system and that the vascular and lymphatic systems develop independently...
  25. ncbi A role for hematopoietic stem cells in promoting angiogenesis
    N Takakura
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Cell 102:199-209. 2000
    ..HSCs, which express Ang1, directly promoted migration of ECs in vivo and in vitro. These results indicate that HSCs are critical for angiogenesis...
  26. pmc Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    Y Liu
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1821, USA
    J Clin Invest 106:951-61. 2000
    ..Our data reveal Edg-1 to be the first G protein-coupled receptor required for blood vessel formation and show that sphingolipid signaling is essential during mammalian development...
  27. pmc beta8 integrins are required for vascular morphogenesis in mouse embryos
    Jiangwen Zhu
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Development 129:2891-903. 2002
    ..This study thus identifies a molecule crucial for vascular patterning in embryonic yolk sac and brain...
  28. ncbi A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
    Eleni Tzima
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 437:426-31. 2005
    ..Here we investigate the pathway upstream of integrin activation. PECAM-1 (which directly transmits mechanical force), vascular endothelial cell cadherin (which functions as an adaptor) ..
  29. pmc Vascular development of the brain requires beta8 integrin expression in the neuroepithelium
    John M Proctor
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, California 94143, USA
    J Neurosci 25:9940-8. 2005
    ....
  30. pmc Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation
    Rickmer Braren
    The Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery, Howard Hughes Medical Institute, San Francisco, CA 94143, USA
    J Cell Biol 172:151-62. 2006
    ..This study reveals that FAK is crucial for vascular morphogenesis and the regulation of EC survival and morphology...
  31. pmc The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine B6, Suita, Japan
    J Am Soc Nephrol 20:1714-23. 2009
    ..We conclude that CXCL12 secreted from stromal cells or podocytes acts on endothelial cells to regulate vascular development in the kidney. These findings suggest new potential therapeutic targets for remodeling the injured kidney...
  32. doi CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo
    Frank L Bos
    Hubrecht Institute KNAW, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Circ Res 109:486-91. 2011
    ..Insight into the molecular role of CCBE1 is completely lacking, and mouse models for the disease do not exist...
  33. doi Neuropilin-1 expression in cancer and development
    Adrian M Jubb
    Department of Pathology, Genentech Inc, South San Francisco, CA 94080, USA
    J Pathol 226:50-60. 2012
    ..These observations confirm NRP1 as a valid anti-angiogenic target in malignancy, and as a potential direct anti-tumour target in a subset of cancers. The data also confirm a role for NRP1 in physiological, VEGF-mediated angiogenesis...
  34. doi Segmental territories along the cardinal veins generate lymph sacs via a ballooning mechanism during embryonic lymphangiogenesis in mice
    Mathias Francois
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Dev Biol 364:89-98. 2012
    ..Our data support a new model for lymphatic vascular patterning and morphogenesis, as a basis for identifying the molecular cues governing these processes...
  35. doi Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation
    Amélie Sabine
    Division of Experimental Oncology, Multidisciplinary Oncology Center, University Hospital of Lausanne, Switzerland
    Dev Cell 22:430-45. 2012
    ..Our results also provide molecular insights into the role of endothelial cell identity in the regulation of vascular mechanotransduction...
  36. pmc Runx2 protein stabilizes hypoxia-inducible factor-1α through competition with von Hippel-Lindau protein (pVHL) and stimulates angiogenesis in growth plate hypertrophic chondrocytes
    Sun Hee Lee
    School of Life Sciences and Biotechnology, College of Natural Sciences, Daegu 702 701, South Korea
    J Biol Chem 287:14760-71. 2012
    ..mice, HIF-1α and Runx2 were colocalized in hypertrophic chondrocytes in which the cluster of differentiation 31 (CD31) protein was expressed at embryonic day 15.5 (E15.5)...
  37. pmc Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins
    Joseph H McCarty
    Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 22:7667-77. 2002
    ..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
  38. ncbi Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis
    Harikrishna Tanjore
    Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Dev Dyn 237:75-82. 2008
    ..5. The embryos exhibit growth retardation and both histological evaluation and PECAM-1 staining of E9.5 embryos revealed defects in angiogenic sprouting and vascular branching morphogenesis...
  39. ncbi Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice
    L Kwee
    Department of Biotechnology, Roche Research Center, Hoffmann La Roche Inc, Nutley, NJ 07110 1199, USA
    Development 121:489-503. 1995
    ..These data suggest important roles for VCAM-1 and alpha 4 in the development of the placenta and the heart...
  40. ncbi Molecular and functional aspects of PECAM-1/CD31
    H M DeLisser
    Dept of Medicine, University of Pennsylvania Medical Center, Philadelphia 19104
    Immunol Today 15:490-5. 1994
    Among vascular cell adhesion molecules, platelet-endothelial cell adhesion molecule (PECAM-1/CD31) has the distinctive feature of being expressed on several of the major cell types associated with the vascular compartment...
  41. ncbi Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
    P C Maisonpierre
    Regeneron Pharmaceuticals Inc, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Science 277:55-60. 1997
    ..Natural antagonists for vertebrate receptor tyrosine kinases are atypical; thus, the discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system...
  42. ncbi YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 126:1845-57. 1999
    ..These data demonstrate a variety of new functions for WT1 and suggest a general requirement for this protein in the formation of organs derived from the intermediate mesoderm...
  43. ncbi PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development
    Aaron D Gitler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Cell 7:107-16. 2004
    ..Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis...
  44. pmc Sphingosine 1-phosphate receptor regulation of N-cadherin mediates vascular stabilization
    Ji Hye Paik
    Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3501, USA
    Genes Dev 18:2392-403. 2004
    ..S1P-induced trafficking and activation of N-cadherin provides a novel mechanism for the stabilization of nascent blood vessels by mural cells and may be exploited to control angiogenesis and vascular diseases...
  45. pmc An obligatory role of mind bomb-1 in notch signaling of mammalian development
    Bon Kyoung Koo
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
    PLoS ONE 2:e1221. 2007
    ..However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood...
  46. pmc Netrin-4 induces lymphangiogenesis in vivo
    Frederic Larrieu-Lahargue
    Program in Molecular Medicine, Department of Medicine, University of Utah, Salt Lake City, UT, USA
    Blood 115:5418-26. 2010
    ..Together, these data provide evidence that Netrin-4 is a lymphangiogenic factor contributing to tumor dissemination and represents a potential target to inhibit metastasis formation...
  47. pmc Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development
    Arjan van der Flier
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 137:2439-49. 2010
    ..These integrins on other cells, and/or other integrins on endothelial cells, might contribute to fibronectin assembly and vascular development...
  48. pmc Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos
    Tomomasa Yokomizo
    Erasmus MC Stem Cell Institute, Department of Cell Biology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands
    Development 137:3651-61. 2010
    ..Clusters enriched with the c-Kit(+)CD31(+)SSEA1(-) cell population contain functional hematopoietic progenitors and stem cells...
  49. pmc Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism
    Ann C Zovein
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 18:39-51. 2010
    ..Combined, our findings demonstrate that beta1 integrin functions upstream of Par3 as part of a molecular cascade required for endothelial cell polarity and lumen formation...
  50. pmc T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema
    Vivien Schacht
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    EMBO J 22:3546-56. 2003
    ..These data identify T1alpha/podoplanin as a novel critical player that regulates different key aspects of lymphatic vasculature formation...
  51. ncbi Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination
    Jennifer Schmahl
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Development 131:3627-36. 2004
    ..The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate...
  52. ncbi Loss of PECAM-1 function impairs alveolarization
    Horace M DeLisser
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Biol Chem 281:8724-31. 2006
    ..We therefore targeted the function of platelet endothelial cell adhesion molecule, (PECAM-1), an EC surface molecule that promotes EC migration and has been implicated in in ..
  53. pmc Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects
    Ying Zhang
    Department of Cell and Developmental Biology, Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 325:82-93. 2009
    ..These results demonstrate an important role for PlexinD1 in embryonic and adult vasculature...
  54. ncbi Role of vascular endothelial-cadherin in vascular morphogenesis
    S Gory-Fauré
    Laboratoire de Transgenèse et Différenciation Cellulaire, Atelier de Transgenèse, and Atelier de Microscopie Electronique, Departement de Biologie Moleculaire et Structurale, INSERM IFR27, CEA Grenoble, rue des Martyrs, France
    Development 126:2093-102. 1999
    ..These data indicate that VE-cadherin is dispensable for endothelial homophilic adhesion but is required for vascular morphogenesis...
  55. ncbi MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells
    Bauer E Sumpio
    Department of Surgery Vascular, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 280:11185-91. 2005
    b>PECAM-1 (CD31) is a member of the Ig superfamily of cell adhesion molecules and is expressed on endothelial cells (EC) as several circulating blood elements including platelets, polymorphonuclear leukocytes, monocytes, and lymphocytes...
  56. pmc PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells
    Jean Pierre Couty
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Neurochem 103:793-801. 2007
    ..In the present study, we show that, whereas PECAM-1 is known to control positively the trans-endothelial migration of leukocytes via homophilic interactions between ..
  57. doi Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos
    Elizabeth A V Jones
    Inserm U833, F 75005, Paris, France
    Development 135:2479-88. 2008
    ..This method allows genetic defects caused by loss-of-function of a gene important for cardiovascular development to be isolated even in the presence of hemodynamic defects...
  58. pmc Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development
    Xiaofeng Zhao
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 189:955-65. 2010
    ..Together, our data suggest that kinase-independent functions of FAK can support EC survival in vascular development through E13.5 but are insufficient for maintaining EC function to allow for completion of embryogenesis...
  59. ncbi TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression
    Mario DeFelice
    Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    J Biol Chem 278:35574-83. 2003
    ..Direct and indirect transcriptional targets of TTF-1 were identified that are likely to play important roles in lung formation and function...
  60. ncbi Primitive erythropoiesis from mesodermal precursors expressing VE-cadherin, PECAM-1, Tie2, endoglin, and CD34 in the mouse embryo
    Masatsugu Ema
    Department of Anatomy and Embryology, Institute of Basic Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Blood 108:4018-24. 2006
    Vascular endothelial (VE) cadherin, PECAM-1 (platelet endothelial cell adhesion molecule-1, CD31), Tie2, CD34, and endoglin are established markers for adult and embryonic endothelial cells (ECs)...
  61. pmc Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression
    Carrie J Shawber
    Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York 10032, USA
    J Clin Invest 117:3369-82. 2007
    ..These results demonstrate that Notch1 and VEGFR-3 interact genetically, that Notch directly induces VEGFR-3 in blood endothelial cells to regulate vascular development, and that Notch may function in tumor lymphangiogenesis...
  62. pmc Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants
    Luke T Krebs
    The Jackson Laboratory, Bar Harbor, Maine
    Genesis 48:146-50. 2010
    ..genesis 48:146-150, 2010. (c) 2010 Wiley-Liss, Inc...
  63. ncbi TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth
    S Patan
    Department of Radiation Oncology, Beth Israel Hospital, Boston, Massachusetts, 02114, USA
    Microvasc Res 56:1-21. 1998
    ..Angiopoietin-1, a ligand that activates the TIE2 receptor, is expressed in mesenchymal cells surrounding the endothelium. This local relationship is indicative of a paracrine regulation...
  64. pmc Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis
    Humphrey Hung Chang Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 16:1433-40. 2002
    ....
  65. pmc Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis
    Humphrey H C Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Dev Dyn 230:210-5. 2004
    ..Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary...
  66. ncbi Sry induces cell proliferation in the mouse gonad
    J Schmahl
    The Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 127:65-73. 2000
    ..Therefore, an increase in cell proliferation in the male coelomic epithelium is the earliest identified effect of Sry expression...
  67. pmc Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice
    Timothy R Carlson
    Pacific Vascular Research Laboratory, Division of Vascular Surgery, Department of Surgery and Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Development 135:2193-202. 2008
    ..Our findings demonstrate that beta1 integrin is essential for EC adhesion, migration and survival during angiogenesis, and further validate that therapies targeting beta1 integrins may effectively impair neovascularization...
  68. pmc The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice
    Lee Smith
    Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK
    PLoS ONE 3:e4091. 2008
    ....
  69. pmc The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization
    Kyu Sang Joeng
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 136:4177-85. 2009
    ..These results therefore provide direct genetic evidence that Gli2 and Gli3 collectively mediate all major aspects of Ihh function during endochondral skeletal development...
  70. ncbi Vascular endothelial cell lineage-specific promoter in transgenic mice
    T M Schlaeger
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110 1199, USA
    Development 121:1089-98. 1995
    ..able to differentiate in vitro to form cystic embryoid bodies (CEB) that contain endothelial cells determined by PECAM immunohistochemistry...
  71. pmc Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality
    Mary L Holtz
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    BMC Dev Biol 8:65. 2008
    ..Resulting embryos were harvested at specific ages for observation of physical condition and analysis of genotype...
  72. pmc Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations
    Deepak A Venkatesh
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Circ Res 103:423-31. 2008
    ..Cardiovascular lineages are sensitive to an imbalance in Notch signaling, with aberrant activation reflecting a vascular phenotype comparable to a loss-of-function Notch1 mutation...
  73. pmc Dosage-sensitive requirement for mouse Dll4 in artery development
    Antonio Duarte
    CIISA, Faculdade de Medicina Veterinaria, 1300 0 477 Lisboa, Portugal
    Genes Dev 18:2474-8. 2004
    ..This implicates Dll4 as the specific mammalian endothelial ligand for autocrine endothelial Notch signaling, and suggests that Dll4 may be a suitable target for intervention in arterial angiogenesis...
  74. pmc Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
    Masaki Inada
    Center for Immunology and Inflammatory Diseases, Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Building 149, 13th Street, Room 8301, Boston, MA 02129, USA
    Proc Natl Acad Sci U S A 101:17192-7. 2004
    ..Cartilaginous growth plate abnormalities persisted in adult mice and phenocopied defects observed in human hereditary chondrodysplasias. Our findings demonstrate a unique role of Mmp13 in skeletal development...
  75. ncbi Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation
    C M Alexander
    Laboratory of Radiobiology, Department of Biopharmaceutical Sciences, University of California, San Francisco, 94143, USA
    Development 122:1723-36. 1996
    ..We conclude that administration of MMP inhibitors retards decidual remodeling and growth, and we suggest that the MMPs expressed in precursor stromal cells promote their differentiation and expansion...
  76. pmc Platelet-endothelial cell adhesion molecule-1 (PECAM-1/CD31) tyrosine phosphorylation state changes during vasculogenesis in the murine conceptus
    E Pinter
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Am J Pathol 150:1523-30. 1997
    ..this report we demonstrate differential tyrosine phosphorylation of platelet-endothelial cell adhesion molecule-1 (PECAM-1) during the formation of blood islands and vessels from clusters of extraembryonic and embryonic angioblasts in ..
  77. ncbi Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions
    G S Duncan
    Amgen Institute, Toronto, Ontario, Canada
    J Immunol 162:3022-30. 1999
    Platelet/endothelial cell adhesion molecule-1 (PECAM-1; CD31), a member of the Ig superfamily, is expressed strongly at endothelial cell-cell junctions, on platelets, and on most leukocytes...
  78. ncbi Vasculogenesis in the day 6.5 to 9.5 mouse embryo
    C J Drake
    Medical University of South Carolina, Department of Cell Biology and the Cardiovascular Developmental Biology Center, Charleston, SC 29425, USA
    Blood 95:1671-9. 2000
    ..endothelial or hematopoietic lineage-associated proteins, TAL1, Flk1, platelet/endothelial cell adhesion molecule (PECAM), CD34, VE-cadherin, and Tie2...
  79. pmc Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis
    J S Mudgett
    Merck Research Laboratories, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 97:10454-9. 2000
    ..Thus, our results indicate a requirement for p38alpha MAPK in diploid trophoblast development and placental vascularization and suggest a more general role for p38 MAPK signaling in embryonic angiogenesis...
  80. ncbi Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2
    E Zelzer
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mech Dev 106:97-106. 2001
    ..The results demonstrate that Cbfa1 is a necessary component of a tissue specific genetic program that regulates VEGF during endochondral bone formation...
  81. ncbi Hedgehog is required for murine yolk sac angiogenesis
    Noah Byrd
    Department of Biology, Wesleyan University, CT 06459, USA
    Development 129:361-72. 2002
    ..Embryoid bodies derived from these cell lines are unable to form blood islands, and express reduced levels of both PECAM1, an endothelial cell marker, and alpha-SMA, a vascular smooth muscle marker...
  82. pmc Altered vascular permeability and early onset of experimental autoimmune encephalomyelitis in PECAM-1-deficient mice
    Donnasue Graesser
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 109:383-92. 2002
    Platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31), a 130-kDa glycoprotein member of the Ig superfamily of transmembrane proteins, is expressed on endothelial cells, platelets, and subsets of leukocytes...
  83. ncbi Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis
    Elazar Zelzer
    Harvard Medical School, Department of Cell Biology, 240 Longwood Avenue, Boston, MA, USA
    Development 129:1893-904. 2002
    ..We also describe new in vivo evidence for a possible role of VEGF in chondrocyte maturation, and document that VEGF has a direct role in regulating osteoblastic activity based on in vivo evidence and organ culture experiments...
  84. pmc Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
    Christopher P Regan
    Vertex Pharmaceuticals, Department of Biology, 130 Waverly Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:9248-53. 2002
    ..Together, these data define an essential role for Erk5 in cardiovascular development. Moreover, the inability of Erk5-deficient mice to form a complex vasculature suggests that Erk5 may play an important role in controlling angiogenesis...
  85. pmc Lack of platelet endothelial cell adhesion molecule-1 attenuates foreign body inflammation because of decreased angiogenesis
    Anna Solowiej
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Pathol 162:953-62. 2003
    b>Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a 130-kd member of the immunoglobulin superfamily of proteins, expressed on endothelial cells, leukocytes, and platelets...
  86. pmc PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature
    Taija Makinen
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
    Genes Dev 19:397-410. 2005
    ..Our studies define ephrinB2 as an essential regulator of lymphatic development and indicate that interactions with PDZ domain effectors are required to mediate its functions...
  87. ncbi The inhibitory co-receptor, PECAM-1 provides a protective effect in suppression of collagen-induced arthritis
    Mae Xhum Wong
    Austin Research Institute, Austin Hospital, Heidelberg, Victoria, Australia
    J Clin Immunol 25:19-28. 2005
    Studies of PECAM-1(-/-) mice have identified that PECAM-1 functions as an inhibitory co-receptor to modulate immunological responsiveness...
  88. pmc Functionally specialized junctions between endothelial cells of lymphatic vessels
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 204:2349-62. 2007
    ..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics...
  89. pmc FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network
    Andrew C White
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 134:3743-52. 2007
    ..These data suggest a molecular mechanism through which FGF9 and SHH signaling coordinately control the growth and patterning of the lung capillary plexus, and regulate the temporal and spatial expression of Vegfa...
  90. doi Comparative analysis of anti-mouse SRY antibodies
    S T Bradford
    Division of Molecular Genetics and Development, The University of Queensland, Brisbane, QLD, Australia
    Sex Dev 1:305-10. 2007
    ..Our findings underline the need to distinguish between useful and spurious reagents for biochemical and immunolocalization studies involving mouse SRY protein...
  91. doi Pofut1 is required for the proper localization of the Notch receptor during mouse development
    Yoshiaki Okamura
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Mech Dev 125:663-73. 2008
    ..We propose that altered trafficking pathways may account for the abnormal accumulation of the Notch1 receptor in the endoplasmic reticulum in Pofut1-null mouse embryos...
  92. ncbi Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development
    H S Baldwin
    Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104
    Development 120:2539-53. 1994
    ..b>Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) may well serve such a function...
  93. ncbi Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system
    G Breier
    Max Planck Institut fur Physiologische und Klinische Forschung, Bad Nauheim, Germany
    Blood 87:630-41. 1996
    ..This distinguishes this molecule from other cadherins and suggests that its expression is associated with the early assembly of vascular structures...
  94. ncbi Regulation of mouse PECAM-1 tyrosine phosphorylation by the Src and Csk families of protein-tyrosine kinases
    M Y Cao
    McGill Cancer Centre, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 273:15765-72. 1998
    b>PECAM-1 is an adhesion molecule expressed on hemopoietic and endothelial cells. Recently, it was observed that PECAM-1 becomes tyrosine-phosphorylated in response to a variety of physiological stimuli...
  95. ncbi Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
    D J Dumont
    Ontario Cancer Institute and Amgen Institute, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2C1
    Science 282:946-9. 1998
    ..5. Thus, VEGFR-3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels...
  96. ncbi Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1
    Y Xue
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609 1500, USA
    Hum Mol Genet 8:723-30. 1999
    ..These results establish the phenotype of Cm /+ mice as a contiguous gene deletion syndrome and demonstrate that Jag1 is essential for remodeling of the embryonic vasculature...
  97. ncbi Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
    P Carmeliet
    Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Leuven, Belgium
    Cell 98:147-57. 1999
    ..Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival...
  98. pmc Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells
    K Morita
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 147:185-94. 1999
    ..e., the extracellular face-associated TJs. These findings indicated that claudin-5/TMVCF is an endothelial cell-specific component of TJ strands...
  99. ncbi A requirement for neuropilin-1 in embryonic vessel formation
    T Kawasaki
    Group of Developmental Neurobiology, Division of Biological Science, Nagoya University Graduate School of Science, Chikusa ku, Nagoya 464 8602, Japan
    Development 126:4895-902. 1999
    ..The vascular defects induced by neuropilin-1 deficiency in mouse embryos suggest that neuropilin-1 plays roles in embryonic vessel formation, as well as nerve fiber guidance...
  100. ncbi The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome
    K M Loomes
    Division of Human Genetics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 8:2443-9. 1999
    ..These data are consistent with an important role for JAG1 and Notch signaling in early mammalian cardiac development...
  101. ncbi Essential role of p38alpha MAP kinase in placental but not embryonic cardiovascular development
    R H Adams
    European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Cell 6:109-16. 2000
    ..Our results indicate that p38alpha is required for placental organogenesis but is not essential for other aspects of mammalian embryonic development...

Research Grants25

  1. Gap Junction Mediated Signaling and Vascular Responses
    Alexander M Simon; Fiscal Year: 2010
    ..Finally, these studies could also lead to new approaches to control vasculogenesis and angiogenesis in other clinically important settings, such as anti-angiogenesis treatments designed to fight cancer. ..
  2. Zeiss Dynamic Laser TIRF
    Richard Minshall; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  4. Role of KLF2 in erythropoiesis and globin expression
    Joyce A Lloyd; Fiscal Year: 2010
    ..Our long-term goal is to use KLF2 in strategies to increase embryonic/fetal beta-globin, to treat patients with beta-hemoglobinopathies. ..
  5. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard D Minshall; Fiscal Year: 2011
    ....
  6. ID2 IN CELL CYCLE REGULATION AND CANCER
    Antonio Iavarone; Fiscal Year: 2010
    ..The proposed work will define the mechanisms underlying regulation of Id2 and enhance our understanding of the involvement of uncontrolled Id2 activity in human cancer. ..
  7. Negative regulation of platelet activity
    DEBRA KAY NEWMAN; Fiscal Year: 2010
    ..We and others have previously demonstrated that Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1, also called CD31) and the SFK, Lyn, are negative regulators of platelet activation...
  8. Human Se Nutritional Requirement and Biomarkers in Health and Disease
    Raymond F Burk; Fiscal Year: 2010
    ..All these studies are aimed at facilitating efforts to determine the health effects of selenium deficiency and to guide supplementation of the element when that is needed. ..
  9. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  10. Phenotypic screen in mouse embryonic for TGF-beta signaling mutations
    JAY VIVIAN; Fiscal Year: 2007
    ..Cell-based mutation screening strategies as developed in this proposal can be applied to any active biochemical pathway in mouse ES cells, to generate mouse lines for analysis in vivo. [unreadable] [unreadable] [unreadable]..
  11. Mechanisms By Which Endothelium Cells Sense Changes in Hemodynamics
    Bauer Sumpio; Fiscal Year: 2007
    ..4. Assess egr-1 and sp1 binding in MT1-MMP and PDGF-B promoters under mechanical stress 5.Assess the functional relevance of egr-1 in a low flow carotid model using an egr-1 knock-out mouse. ..
  12. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  13. Somatic support cell function in gonad development
    GERRIT BOUMA; Fiscal Year: 2006
    ..The proposed experiments will identify genes expressed in gonadal SSCs that play a role in gonadal XY sex reversal. ..
  14. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  15. HAND GENES IN CARDIAC DEVELOPMENT
    William Pu; Fiscal Year: 2004
    ..This experience, and the information generated in this plan, will launch the applicant's career as an independent investigator. ..
  16. REGULATION OF HUMAN GAMMA AND BETA GLOBIN GENES
    Joyce Lloyd; Fiscal Year: 2003
    ..These results will predict the proteins involved in early beta-globin gene suppression. ..
  17. NUTRITIONAL AND METABOLIC SIGNIFICANCE OF SELENIUM
    Raymond Burk; Fiscal Year: 2003
    ..These and other studies are proposed to evaluate the role of Se-P in protecting endothelial cells (and other cells) against oxidant substances in the extracellular space. ..
  18. PECAM AND CALCIUM SIGNALING AND TRANSMIGRATION
    Steven Albelda; Fiscal Year: 2002
    DESCRIPTION (Adapted from Investigator's Abstract): Platelet-endothelial cell adhesion molecule-1 (PECAM-1) is a member of the immunoglobulin superfamily that is expressed at high levels on endothelial intercellular junctions and ..
  19. CYTOKINE REGULATION OF EARLY EVENTS IN BLOOD VESSEL FORM
    Christopher Drake; Fiscal Year: 2006
    ..abstract_text> ..
  20. Transcriptional Control of Early Coronary Vascular Development
    RAVINDRA P MISRA; Fiscal Year: 2010
    ....
  21. The Role of PECAM in Models of Lung Injury
    Steven Albelda; Fiscal Year: 2005
    Platelet-Endothelial Cell Adhesion Molecule-1 (PECAM-1, CD31) is an adhesion and signaling molecule that is expressed on endothelial cells (EC), leukocytes, and platelets...
  22. THE ROLE OF SRF IN CARDIAC FUNCTION AND DEVELOPMENT
    RAVINDRA MISRA; Fiscal Year: 2005
    ..These studies will both elucidate the mechanisms by which SRF functions in heart and will establish powerful new methodologies for studying heart formation and function. ..
  23. FN FAK SIGNALING AXIS AND TUMORIGENESIS
    Dusko Ilic; Fiscal Year: 2004
    ..abstract_text> ..
  24. Epithelial Cell Structure in Vertebrate Development
    Jeffrey D Hildebrand; Fiscal Year: 2010
    ..We will continue to use in vivo studies in mice and in vitro studies in cell culture to understand the molecular mechanisms underlying human birth defects. ..
  25. Modifiers of a Mouse Model of Alagille Syndrome
    Thomas Gridley; Fiscal Year: 2008
    ..These studies will enable us to create more representative mouse models of Alagille syndrome, and should provide insight into the variable phenotypic expression observed in Alagille syndrome patients. [unreadable] [unreadable]..