Pdx1

Summary

Gene Symbol: Pdx1
Description: pancreatic and duodenal homeobox 1
Alias: IDX-1, IPF-1, Ipf1, Mody4, STF-1, pdx-1, pancreas/duodenum homeobox protein 1, insulin promoter factor 1, homeodomain transcription factor, islet/duodenum homeobox 1, pancreatic and duodenal homeobox gene 1, somatostatin-transactivating factor 1
Species: mouse

Top Publications

  1. ncbi A mouse carrying the green fluorescent protein gene targeted to the Pdx1 locus facilitates the study of pancreas development and function
    Andrew M Holland
    Genesis 44:304-7. 2006
  2. pmc Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1
    Joshua Francis
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 20:3133-45. 2006
  3. pmc Sox9 coordinates a transcriptional network in pancreatic progenitor cells
    F C Lynn
    Diabetes Center, Hormone Research Institute, and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:10500-5. 2007
  4. ncbi The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    Yoshiya Kawaguchi
    Vanderbilt Developmental Biology Program, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232 2175, USA
    Nat Genet 32:128-34. 2002
  5. pmc PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 114:828-36. 2004
  6. ncbi Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    Guoqiang Gu
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 129:2447-57. 2002
  7. pmc SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
  8. pmc Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
  9. ncbi Stabilization of beta-catenin impacts pancreas growth
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 133:2023-32. 2006
  10. pmc Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation
    Sui Wang
    Program in Developmental Biology, Department of Cell and Developmental Biology, 465 21st Avenue South, Rm 4128, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 317:531-40. 2008

Research Grants

Scientific Experts

Detail Information

Publications174 found, 100 shown here

  1. ncbi A mouse carrying the green fluorescent protein gene targeted to the Pdx1 locus facilitates the study of pancreas development and function
    Andrew M Holland
    Genesis 44:304-7. 2006
    The pancreatic and duodenal homeobox gene 1 (Pdx1) has multiple roles in the specification and development of foregut endoderm-derived tissues...
  2. pmc Role of chromatin accessibility in the occupancy and transcription of the insulin gene by the pancreatic and duodenal homeobox factor 1
    Joshua Francis
    Department of Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Endocrinol 20:3133-45. 2006
    ....
  3. pmc Sox9 coordinates a transcriptional network in pancreatic progenitor cells
    F C Lynn
    Diabetes Center, Hormone Research Institute, and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:10500-5. 2007
    ..These studies indicate that Sox9 plays a dual role in pancreatic progenitor cells: both maintaining a stable transcriptional network and supporting the programs by which these cells differentiate into distinct lineages...
  4. ncbi The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors
    Yoshiya Kawaguchi
    Vanderbilt Developmental Biology Program, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, Tennessee 37232 2175, USA
    Nat Genet 32:128-34. 2002
    ..Ptf1a supports the specification of precursors of all three pancreatic cell types, transgene-based expression of Pdx1, a gene essential to pancreas formation, from Ptf1a cis-regulatory sequences restores pancreas tissue to Pdx1-null ..
  5. pmc PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
    Rohit N Kulkarni
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 114:828-36. 2004
    ..This study shows that, in postdevelopmental states of beta cell growth, PDX-1 is a critical regulator of beta cell replication and is required for the compensatory response to insulin resistance...
  6. ncbi Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    Guoqiang Gu
    Department of Molecular and Cellular Biology, and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 129:2447-57. 2002
    ..have employed an inducible Cre-ER(TM)-LoxP system to indelibly mark the progeny of cells expressing either Ngn3 or Pdx1 at different stages of development...
  7. pmc SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
    ..In the developing pancreas, SOX9 expression is restricted to a mitotically active, Notch-responsive subset of PDX1(+) pluripotent progenitors and is absent from committed endocrine precursors or differentiated cells...
  8. pmc Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
    ..Thus, cross-antagonism between Nkx6 and Ptf1a in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development...
  9. ncbi Stabilization of beta-catenin impacts pancreas growth
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 133:2023-32. 2006
    ..of beta-catenin during early organogenesis drives changes in hedgehog and Fgf10 signaling and induces a loss of Pdx1 expression in early pancreatic progenitor cells...
  10. pmc Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation
    Sui Wang
    Program in Developmental Biology, Department of Cell and Developmental Biology, 465 21st Avenue South, Rm 4128, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 317:531-40. 2008
    ....
  11. pmc Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression
    Teresa L Mastracci
    Department of Genetics and Development, Russ Berrie Medical Pavilion, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
    Dev Biol 359:1-11. 2011
    ..Together, these experiments identify novel genetic interactions between Nkx2.2 and Arx within the endocrine progenitor cells that ensure the correct specification and regulation of endocrine hormone-producing cells...
  12. ncbi Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
    Ben Z Stanger
    Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, and Howard Hughes Medical Institute, Cambridge, Massachusetts 02138, USA
    Nature 445:886-91. 2007
    ..By contrast, the size of the liver is not constrained by reductions in the progenitor cell pool. These findings show that progenitor cell number, independently of regulation by growth factors, can be a key determinant of organ size...
  13. ncbi The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
    Junfeng Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 266:178-89. 2004
    ..essential for appropriate initiation of beta-cell differentiation because loss of Pax4 prevents the expression of Pdx1, HB9 and insulin in beta-cell precursors...
  14. ncbi Beta-catenin is essential for pancreatic acinar but not islet development
    L Charles Murtaugh
    Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 132:4663-74. 2005
    ..Thus, our data are consistent with a crucial role for canonical Wnt signals in acinar lineage specification and differentiation...
  15. pmc Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation
    Patricia M Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10476, USA
    Endocrinology 147:3995-4006. 2006
    ..These findings suggest that GLU participates in a feedback loop that regulates the proportion of the different endocrine cell types in islets, the number of islets per pancreas, and development of the mature alpha-cell phenotype...
  16. pmc A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 323:19-30. 2008
    ..Our findings therefore suggest that defective endocrine specification might underlie the pancreatic phenotype of individuals with CD...
  17. pmc Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas
    Sui Wang
    Program in Developmental Biology and Department of Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University Medical Center, 465 21st Avenue South, Rm 4128, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Dev Biol 339:26-37. 2010
    ..The control of Neurog3+ cell number and the Neurog3 threshold-dependent endocrine differentiation mechanism combine to select a specific proportion of pancreatic progenitor cells to adopt the islet cell fate...
  18. ncbi Expression of neurogenin3 reveals an islet cell precursor population in the pancreas
    V M Schwitzgebel
    Hormone Research Institute, Department of Pediatrics, and Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Development 127:3533-42. 2000
    ..5. Although not detected in cells expressing islet hormones or the islet transcription factors Isl1, Brn4, Pax6 or PDX1, neurogenin3 is detected along with early islet differentiation factors Nkx6.1 and Nkx2...
  19. ncbi Foxa2 is required for the differentiation of pancreatic alpha-cells
    Catherine S Lee
    Department of Genetics and Penn Diabetes Center, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB 560 Philadelphia, PA 19104, USA
    Dev Biol 278:484-95. 2005
    ..By marker gene analysis, we show that the expression of the alpha-cell transcription factors Arx, Pax6, and Brn4 does not require Foxa2 in the transcriptional hierarchy governing alpha-cell differentiation...
  20. ncbi Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter
    Miwako Kajihara
    Department of Internal Medicine, University of Tsukuba, 1 1 1, Tennodai, Tsukuba 305 8575, Japan
    Biochem Biophys Res Commun 312:831-42. 2003
    ..These results indicate that MafA is the homologue of zebrafish SMaf1 and acts as a transcriptional activator of the insulin gene promoter through the RIPE3b element...
  21. pmc Lack of TCF2/vHNF1 in mice leads to pancreas agenesis
    C Haumaitre
    Biologie du Développement, Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:1490-5. 2005
    ..5. At earlier stages, only a dorsal bud rudiment forms transiently and expresses the transcription factors Ipf1 and Hlxb9 but lacks the key transcription factor involved in the acquisition of a pancreatic fate, Ptf1a, as well ..
  22. doi Biphasic induction of Pdx1 in mouse and human embryonic stem cells can mimic development of pancreatic beta-cells
    Andreia S Bernardo
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Stem Cells 27:341-51. 2009
    ..a detailed understanding of how the transcription factor cascade initiated by the homeodomain transcription factor Pdx1 culminates in pancreatic beta-cell development...
  23. pmc Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas
    Aiping Du
    Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2059-69. 2009
    ....
  24. pmc Pdx1 (MODY4) regulates pancreatic beta cell susceptibility to ER stress
    Mira M Sachdeva
    Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:19090-5. 2009
    ..pancreatic duodenal homeobox 1 (Pdx1) are associated with both T2DM and maturity onset diabetes of the young (MODY4), and low levels of Pdx1 accompany beta cell dysfunction in experimental models of glucotoxicity and diabetes...
  25. pmc Rfx6 directs islet formation and insulin production in mice and humans
    Stuart B Smith
    Diabetes Center, University of California San Francisco, San Francisco, California 94143, USA
    Nature 463:775-80. 2010
    ..These studies demonstrate a unique position for Rfx6 in the hierarchy of factors that coordinate pancreatic islet development in both mice and humans. Rfx6 could prove useful in efforts to generate beta-cells for patients with diabetes...
  26. pmc ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells
    Gabriela Da Silva Xavier
    Section of Cell Biology, Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Imperial College London, UK
    Biochem Biophys Res Commun 402:252-7. 2010
    ..These data suggest that strategies to reduce ChREBP activity might protect against β-cell dysfunction in type 2 diabetes...
  27. pmc Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
    ..2-deficient pancreata. Hence in order to precise the functional link between both factors we performed a comparative analysis of Nkx2.2/Arx single- and double-mutants but also of Pax6-deficient animals...
  28. pmc Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1
    M K Thomas
    Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 108:319-29. 2001
    ..Therapeutic strategies to attain normal glucose homeostasis by restoring normal IDX-1 levels may be of particular importance for older individuals with diabetes mellitus...
  29. ncbi Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen
    Byeong Moo Kim
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 134:3603-13. 2007
    ..These observations place Barx1 proximally within a Wt1 pathway of spleen development and reveal how a homeotic regulator employs different molecular mechanisms to mold neighboring organs...
  30. ncbi PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    M F Offield
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 122:983-95. 1996
    ..These results offer additional insight into the role of pdx-1 in the determination and differentiation of the posterior foregut, particularly regarding the proliferation and differentiation of the pancreatic progenitors...
  31. ncbi Induction of pancreatic differentiation by signals from blood vessels
    E Lammert
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Science 294:564-7. 2001
    ..These results indicate that vessels not only provide metabolic sustenance, but also provide inductive signals for organ development...
  32. ncbi Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood
    Hongxiang Hui
    Division of Diabetes, Endocrinology and Metabolism, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Eur J Endocrinol 146:129-41. 2002
    ..The dual action of PDX-1, as a differentiation factor during embryogenesis and as a regulator of islet cell physiology in mature islet cells, underscores the unique role of PDX-1 in health and disease of the human endocrine pancreas...
  33. ncbi MicroRNA expression is required for pancreatic islet cell genesis in the mouse
    Francis C Lynn
    Diabetes Center, Hormone Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0534, USA
    Diabetes 56:2938-45. 2007
    ..We tested the hypothesis that microRNAs (miRNAs), which limit gene expression through posttranscriptional silencing, modulate the gene expression cascades involved in pancreas development...
  34. doi Conditional ablation of Notch signaling in pancreatic development
    Hassan Nakhai
    Department of Internal Medicine, Technical University of Munich, Ismaniger Strasse 22, 81675 Munich, Germany
    Development 135:2757-65. 2008
    ..Furthermore, our findings suggest that in late stages of pancreatic development exocrine cell differentiation and maintenance are independent of Rbpj...
  35. pmc The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice
    Jennifer M Oliver-Krasinski
    Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:1888-98. 2009
    ..factor pancreatic duodenal homeobox 1 (PDX1) are associated with maturity onset diabetes of the young, type 4 (MODY4) and type 2 diabetes...
  36. ncbi The Pax4 gene is essential for differentiation of insulin-producing beta cells in the mammalian pancreas
    B Sosa-Pineda
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Nature 386:399-402. 1997
    ..A default pathway would explain the elevated number of alpha cells in the absence of Pax4...
  37. pmc A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 02215, USA
    Dev Biol 293:526-39. 2006
    ..Thus, this redundancy in the function and expression of the large-Maf factors may explain the normal islet morphology observed in the MafA knockout mice at birth...
  38. ncbi Ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum
    Qian Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Dev Dyn 237:51-61. 2008
    ..endocrine cell type that expresses ghrelin, glucagon, islet amyloid polypeptide (IAPP), and low levels of Pdx1. Lineage-tracing analysis revealed that most of these unique endocrine cells directly arose from Pax4-deficient ..
  39. pmc Glucose regulates steady-state levels of PDX1 via the reciprocal actions of GSK3 and AKT kinases
    Rohan K Humphrey
    Department of Pediatrics, University of California San Diego, La Jolla, California 92037, USA
    J Biol Chem 285:3406-16. 2010
    The pancreatic beta cell is sensitive to even small changes in PDX1 protein levels; consequently, Pdx1 haploinsufficiency can inhibit beta cell growth and decrease insulin biosynthesis and gene expression, leading to compromised glucose-..
  40. pmc Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells
    Per Svensson
    Umeå Center for Molecular Medicine, Umea University, SE 901 87 Umea, Sweden
    BMC Dev Biol 7:129. 2007
    The homeodomain transcription factor IPF1/PDX1 exerts a dual role in the pancreas; Ipf1/Pdx1 global null mutants fail to develop a pancreas whereas conditional inactivation of Ipf1/Pdx1 in beta-cells leads to impaired beta-cell function ..
  41. pmc Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, USA
    Dev Biol 314:443-56. 2008
    ..Thus, Pax6 acts upstream of MafB, which in turn may trigger the expression of insulin and regulate the PDX-1 and MafA expression required for beta-cell maturation...
  42. pmc Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development
    Josselin Soyer
    Institute of Genetics and Molecular and Cell Biology IGBMC, INSERM U 964, CNRS UMR7104, University of Strasbourg, Illkirch, France
    Development 137:203-12. 2010
    ..Rfx6 is initially expressed broadly in the gut endoderm, notably in Pdx1-positive cells in the developing pancreatic buds, and then becomes progressively restricted to the endocrine ..
  43. pmc Functional conservation of regulatory elements in the pdx-1 gene: PDX-1 and hepatocyte nuclear factor 3beta transcription factors mediate beta-cell-specific expression
    S Marshak
    Department of Endocrinology and Metabolism, Hadassah University Hospital, 91120 Jerusalem, Israel
    Mol Cell Biol 20:7583-90. 2000
    ..This finding suggests a possible autoregulatory loop as a mechanism for PDX-1 to control its own expression...
  44. pmc Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development
    Jean Sebastien Annicotte
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP 67404, Illkirch, France
    Mol Cell Biol 23:6713-24. 2003
    ..Taken together, our data indicate that PDX-1 controls LRH-1 expression and identify LRH-1 as a novel downstream target in the PDX-1 regulatory cascade governing pancreatic development, differentiation, and function...
  45. ncbi Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells
    Grace Flock
    Department of Medicine, Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 146:441-9. 2005
    ..Taken together, these findings demonstrate that pdx-1 alone is not sufficient for specification of the hormonal phenotype or extinction of proglucagon gene expression in islet or enteroendocrine cells...
  46. ncbi Pdx-1 modulates histone H4 acetylation and insulin gene expression in terminally differentiated alpha-TC-1 cells
    Hong Wei Wang
    The Research Institute for Children, Children s Hospital, 200 Henry Clay Avenue, Research and Education Building, Rm 2211, New Orleans, LA 70118, USA
    Pancreas 34:248-53. 2007
    ..In this study, we demonstrated that Pdx-1 is a potent transcriptional regulator of endogenous insulin gene expression in alpha-TC-1 cells...
  47. pmc The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer
    Lynley D Pound
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem J 433:95-105. 2011
    ....
  48. pmc Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells
    Cynthia Khoo
    Institute for Diabetes, Obesity, and Metabolism and Department of Medicine, University of Pennsylvania School of Medicine, Clinical Research Building 726, 415 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 152:2599-608. 2011
    ..Pancreatic and duodenal homeobox 1 (PDX1), a key pancreatic transcription factor, regulates insulin along with targets involved in insulin processing and ..
  49. doi ATF3 represses PDX-1 expression in pancreatic β-cells
    Min Kyung Jang
    Pusan National University, School of Korean Medicine, 30 Beom eo ri, Mulguem eup, Yangsan si, Gyeongnam 609 735, South Korea
    Biochem Biophys Res Commun 412:385-90. 2011
    ..Collectively, these results demonstrate that ATF3 represses PDX-1 expression via binding to an ATF3-responsive element in its promoter, which plays an important role in suppression of pancreatic β-cells function...
  50. doi Comparison of murine embryonic pancreatic development in vitro and in vivo
    Fengxia Ma
    State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin, China
    Pancreas 40:1012-7. 2011
    ..The purpose of the present study was to compare the development of murine embryonic pancreas in vitro and in vivo...
  51. doi ATF3 inhibits PDX-1-stimulated transactivation
    Won Ho Kim
    Division of Metabolic Disease, Department of Biomedical Science, National Institutes of Health, 194 Tongillo, Eunpyung Gu, Seoul 122 701, South Korea
    Biochem Biophys Res Commun 414:681-7. 2011
    ..Taken together, these results suggest that ATF3 inhibits PDX-1-mediated transactivation through the inhibition of p300-stimulated coactivation, which may lead to β-cell dysfunction by ER stress...
  52. ncbi Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells
    G Teitelman
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Brooklyn 11203, USA
    J Neurobiol 34:304-18. 1998
    ..These observations suggest that NGF could play an important role in pancreas during embryogenesis and in processes leading to repair following islet injury in adults...
  53. ncbi Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas
    Maria E Wilson
    UCSF Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0534, USA
    Mech Dev 115:171-6. 2002
    ..The early production of atypical peptide hormones by these cells suggests that they could play an important role locally or systemically in the development of the embryo...
  54. ncbi Reduced PDX-1 expression impairs islet response to insulin resistance and worsens glucose homeostasis
    Marcela Brissova
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism, 715 PRB, Dept of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Am J Physiol Endocrinol Metab 288:E707-14. 2005
    ....
  55. ncbi Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1
    Masayuki Koizumi
    Department of Surgery and Surgical Basic Science, Kyoto University, Sakyo, Japan
    Surgery 138:125-33. 2005
    ..The effect of GLP-1 on the conditionally immortalized pancreatic epithelial cells (IMPE cells) is not clear when they are treated in conjunction with the adenovirus-mediated gene transfer of pdx-1...
  56. ncbi Negative regulation of c-Myc transcription by pancreas duodenum homeobox-1
    Lei Chen
    International Co operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute, Second Military Medical University, 200438 Shanghai, People s Republic of China
    Endocrinology 148:2168-80. 2007
    The pancreatic and duodenal homeobox factor-1 (Pdx1) is essential for pancreatic development and insulin gene transcription, whereas c-Myc has a deleterious effect on islet function...
  57. pmc Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development
    Nan Gao
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Genes Dev 22:3435-48. 2008
    The onset of pancreas development in the foregut endoderm is marked by activation of the homeobox gene Pdx1 (IPF1). Pdx1 is essential for the expansion of the pancreatic primordium and the development of endocrine islets...
  58. doi Forkhead box O1/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic beta-cell dysfunction
    Zhuoxian Meng
    Key Laboratory of Human Functional Genomics of Jiangsu Province, Jiangsu Diabetes Centre, Nanjing Medical University, Nanjing 210029, China
    Endocrinology 150:5284-93. 2009
    ..nuclear exclusion but had no obvious effect on the whole-cell protein level of pancreatic and duodenal homeobox 1 (PDX1). However, these effects were all attenuated by JNK inhibition...
  59. ncbi Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas
    Miguel A Maestro
    Endocrinology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Hum Mol Genet 12:3307-14. 2003
    ..These findings define a precursor cellular stage of the embryonic pancreas and place Hnf1beta in a genetic hierarchy that regulates the generation of pancreatic endocrine cells...
  60. ncbi The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas
    Michael A Hale
    Department of Molecular Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9148, USA
    Dev Biol 286:225-37. 2005
    The homeoprotein PDX1 is expressed throughout pancreatic development and is thought to play important roles at multiple stages. We describe the properties of a tet-off regulatory scheme to manage the expression of Pdx1 in utero...
  61. ncbi Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    Y Guz
    Department of Anatomy and Cell Biology, SUNY Health Science Center at Brooklyn 11203
    Development 121:11-8. 1995
    ....
  62. ncbi Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
    G Waeber
    Department of Internal Medicine B, University Hospital, Lausanne, Switzerland
    Mol Endocrinol 10:1327-34. 1996
    ..These data demonstrate that the murine GLUT2 promoter is controlled by the PDX-1 homeobox factor through the identified GLUT2TAAT motif...
  63. ncbi Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
    L Sussel
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Development 125:2213-21. 1998
    ..These cells express some beta cell markers, such as islet amyloid polypeptide and Pdx1, but lack other definitive beta cell markers including glucose transporter 2 and Nkx6.1. We propose that Nkx2...
  64. ncbi Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas
    R S Heller
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820, Gentofte, Denmark
    Diabetes 50:1553-61. 2001
    ..The mechanisms underlying these observations remain to be elucidated...
  65. pmc Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells
    Taka Aki Matsuoka
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 23:6049-62. 2003
    ..Because MafA, MafB, and c-Maf were each capable of specifically binding to and activating insulin C1 element-mediated expression, our results suggest that all of these factors play a role in islet beta-cell function...
  66. ncbi Mapping of the insulin promoter factor 1 gene (Ipf1) to distal mouse chromosome 5
    F T Fiedorek
    Department of Medicine and Nutrition, University of North Carolina School of Medicine, Chapel Hill 27599, USA
    Genomics 28:581-4. 1995
    We have identified sequence variants in the 3' untranslated region of the insulin promoter factor 1 (Ipf1) cDNA sequence in mice and used a PCR-based oligonucleotide hybridization assay to map the Ipf1 gene to distal mouse chromosome (Chr)..
  67. ncbi Expansion of Pdx1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha
    S Y Song
    Department of Surgery, Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center and Nashville VAMC, Nashville, TN 37232 2736, USA
    Gastroenterology 117:1416-26. 1999
    ..During pancreatic development, differentiated cell types arise from ductal progenitor cells expressing the Pdx1 homeodomain transcription factor...
  68. ncbi Attenuation of FGF signalling in mouse beta-cells leads to diabetes
    A W Hart
    Department of Microbiology and ULMM, Umea University, Sweden
    Nature 408:864-8. 2000
    ..These defects are all characteristic of patients with type-2 diabetes. Mutations in the homeobox gene Ipf1/Pdx1 are linked to diabetes in both mouse and human...
  69. ncbi Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    A Bhushan
    INSERM 457, Hospital Robert Debre, 75019 Paris, France
    Development 128:5109-17. 2001
    ..reduction in the proliferation of the epithelial progenitor cells marked by the production of the homeobox protein PDX1. Furthermore, FGF10 restores the population of PDX1-positive cells in organ cultures derived from Fgf10(-/-) ..
  70. ncbi Regulatory regions driving developmental and tissue-specific expression of the essential pancreatic gene pdx1
    M Gannon
    Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Dev Biol 238:185-201. 2001
    b>pdx1 (pancreatic and duodenal homeobox gene-1), which is expressed broadly in the embryonic pancreas and, later, in a more restricted manner in the mature beta cells in the islets of Langerhans, is essential both for organ formation and ..
  71. ncbi Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus
    Seung K Kim
    Department of Developmental Biology, Beckman Center B300, Stanford University School of Medicine, Stanford, California 94305 5329, USA
    Nat Genet 30:430-5. 2002
    ..In vitro studies have shown that Pbx1 regulates the activity of Ipf1 (also known as Pdx1), a ParaHox homeodomain transcription factor required for the development and function of the ..
  72. ncbi The islet beta cell-enriched RIPE3b1/Maf transcription factor regulates pdx-1 expression
    Susan E Samaras
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 278:12263-70. 2003
    ..These results strongly suggest that RIPE3b1/Maf has an important role in generating and maintaining physiologically functional beta cells...
  73. ncbi Single-cell transcript analysis of pancreas development
    Ming Ko Chiang
    Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Dev Cell 4:383-93. 2003
    ..This form of single-cell transcriptional analysis can be applied to any developmental process or tissue to characterize distinct cell types...
  74. ncbi Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis
    T Miyatsuka
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Biochem Biophys Res Commun 310:1017-25. 2003
    To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in inducing differentiation into insulin-producing cells has been demonstrated in some cells and tissues...
  75. ncbi Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a
    Hideyuki Yoshitomi
    Cell and Developmental Biology Program, Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Development 131:807-17. 2004
    ..that the initial induction of dorsal endoderm cells positive for the pancreatic and duodenal transcription factor Pdx1 does not require aorta or endothelial cell interactions, but dorsal pancreatic bud emergence and the maintenance of ..
  76. ncbi Differential regulation of islet-specific glucose-6-phosphatase catalytic subunit-related protein gene transcription by Pax-6 and Pdx-1
    Cyrus C Martin
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232, USA
    J Biol Chem 279:34277-89. 2004
    ....
  77. ncbi Hepatic regeneration and enforced PDX-1 expression accelerate transdifferentiation in liver
    Masayuki Koizumi
    Department of Surgery and Surgical Basic Science, Kyoto University, Kyoto, Japan
    Surgery 136:449-57. 2004
    ..In this study, we analyzed the plasticity of the liver by enforced expression of PDX-1 in streptozotocin (STZ)-treated mice under the condition of hepatic regeneration...
  78. ncbi Cloning and analysis of Nkx6.3 during CNS and gastrointestinal development
    Tomas Alanentalo
    Umeå Centre for Molecular Medicine, UCMM, Umea University, S 901 87 Umea, Sweden
    Gene Expr Patterns 6:162-70. 2006
    ..2 both in the CNS and in the gut. Transient Nkx6.2 expression was also detected in the developing pancreas. However, analysis of Nkx6.2(-/-) mice did not display any obvious aberrations of pancreatic or stomach development...
  79. ncbi The PDX1 homeodomain transcription factor negatively regulates the pancreatic ductal cell-specific keratin 19 promoter
    Therese B Deramaudt
    Division of Gastroenterology, Departments of Medicine and Genetics, Abramson Cancer Center, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    J Biol Chem 281:38385-95. 2006
    ..Embryologically, the pancreatic and duodenal homeobox 1 (PDX1) homeodomain protein is critical for the initiation of all pancreatic lineages; however, the later differentiation ..
  80. ncbi Insulin-promoter-factor 1 is required for pancreas development in mice
    J Jonsson
    Department of Microbiology, University of Umea, Sweden
    Nature 371:606-9. 1994
    ..Insulin-promoter-factor 1 (IPF1) is a homeodomain protein which, in the adult mouse pancreas, is selectively expressed in the beta-cells and binds ..
  81. ncbi The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice
    U Ahlgren
    Department of Microbiology, University of Umea, Sweden
    Development 122:1409-16. 1996
    We have previously shown that mice carrying a null mutation in the homeobox gene ipf1, now renamed to pdx1, selectively lack a pancreas...
  82. ncbi IPF1, a homeodomain protein with a dual function in pancreas development
    J Jonsson
    Department of Microbiology, University of Umea, Sweden
    Int J Dev Biol 39:789-98. 1995
    Insulin promoter factor 1 (IPF1), is a homeodomain protein which, in the adult mouse pancreas, is selectively expressed in beta-cells, and which binds to, and transactivates, the insulin promoter via the P1 element...
  83. ncbi Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
    U Ahlgren
    Department of Microbiology, University of Umea, Sweden
    Nature 385:257-60. 1997
    ....
  84. pmc Hepatocyte nuclear factor 3beta is involved in pancreatic beta-cell-specific transcription of the pdx-1 gene
    K L Wu
    Department of Molecular Physiology and Biophysics, Vanderbilt Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 17:6002-13. 1997
    ..Together, these results suggest that HNF3beta, a key regulator of endodermal cell lineage development, plays an essential role in the cell-type-specific transcription of the pdx-1 gene in the pancreas...
  85. ncbi Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas
    A Apelqvist
    Department of Microbiology, University of Umea, Sweden
    Curr Biol 7:801-4. 1997
    ..the exception of the pancreatic bud endoderm, which instead expresses high levels of the homeodomain protein Ipf1/Pdx1 (insulin promoter factor 1/pancreatic and duodenal homeobox 1), an essential regulator of early pancreatic ..
  86. pmc beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
    U Ahlgren
    Department of Microbiology, University of Umea, S 901 87 Umea, Sweden
    Genes Dev 12:1763-8. 1998
    To study the late beta-cell-specific function of the homeodomain protein IPF1/PDX1 we have generated mice in which the Ipf1/Pdx1 gene has been disrupted specifically in beta cells...
  87. ncbi Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
    H Li
    Department of Microbiology, University of Umea, S 901 87 Umea, Sweden
    Nat Genet 23:67-70. 1999
    ..The homeodomain protein Pdx1 is expressed in the developing pancreatic anlagen from the approximately 10-somite stage, and mutations in the gene ..
  88. ncbi Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice
    K A Harrison
    Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Genet 23:71-5. 1999
    ..Gene targeting experiments have revealed critical roles for Pdx1, Isl1, Pax4, Pax6 and Nkx2-2 (refs 3,4,5,6,7, 8,9,10)...
  89. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    ..Recent genetic studies have identified a network of transcription factors, including Pdx1, Isl1, Pax4, Pax6, NeuroD, Nkx2...
  90. ncbi Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
    M Sander
    Hormone Research Institute, University of California San Francisco, San Francisco, CA 94143 0534, USA
    Development 127:5533-40. 2000
    ..Together, these experiments reveal two independently controlled pathways for beta-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of beta-cell differentiation...
  91. pmc PDX:PBX complexes are required for normal proliferation of pancreatic cells during development
    S Dutta
    Clayton Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:1065-70. 2001
    ....
  92. ncbi Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function
    C M McKinnon
    Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Diabetologia 44:1203-14. 2001
    ..Heterozygous mutations in the gene result in impaired glucose tolerance and symptoms of diabetes as seen in MODY4 and late-onset Type II (non-insulin-dependent) diabetes mellitus...
  93. ncbi Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding
    Swarup K Chakrabarti
    Department of Medicine, Division of Endocrinology and Metabolism, University of Virginia Health Sciences Center, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    J Biol Chem 277:13286-93. 2002
    The transcription factor Pdx1 is expressed in the pancreatic beta-cell, where it is believed to regulate several beta-cell-specific genes...
  94. pmc Experimental control of pancreatic development and maintenance
    Andrew M Holland
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 99:12236-41. 2002
    To investigate the role of the HOX-like homeoprotein PDX1 in the formation and maintenance of the pancreas, we have genetically engineered mice so that the only source of PDX1 is a transgene that can be controlled by the application of ..
  95. ncbi MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene
    Kohsuke Kataoka
    Frontier Collaborative Research Center, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8503, Japan
    J Biol Chem 277:49903-10. 2002
    ..Therefore, MafA is a beta-cell-specific and glucose-regulated transcriptional activator for insulin gene expression and thus may be involved in the function and development of beta-cells as well as in the pathogenesis of diabetes...
  96. ncbi Regulation of the pdx1 gene promoter in pancreatic beta-cells
    Susan C Campbell
    School of Cell and Molecular Biosciences, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK
    Biochem Biophys Res Commun 299:277-84. 2002
    In the adult pancreas the expression of the transcription factor PDX1 is mainly restricted to the beta-cells of the islets of Langerhans...
  97. ncbi The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells
    Mari Anne Pulkkinen
    Biomedicum Helsinki, Program for Developmental and Reproductive Biology and Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mech Dev 120:167-75. 2003
    ..Our results thus suggest that Fgfr2b-mediated signaling plays a major role in pancreatic ductal proliferation and branching morphogenesis, but has little effect on endocrine and exocrine differentiation...
  98. pmc Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells
    Atsushi Suzuki
    Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Proc Natl Acad Sci U S A 100:5034-9. 2003
    ..Our findings suggest that efficient induction of insulin production in intestinal epithelial cells by GLP-1-(1-37) could represent a new therapeutic approach to diabetes mellitus...
  99. ncbi The Onecut transcription factor HNF-6 (OC-1) is required for timely specification of the pancreas and acts upstream of Pdx-1 in the specification cascade
    Patrick Jacquemin
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75, B 1200 Brussels, Belgium
    Dev Biol 258:105-16. 2003
    ..Moreover, HNF-6 could directly stimulate the Pdx1 promoter...
  100. ncbi Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis
    M Vincent
    Department of Anatomy and Cell Biology, State University of New York, Brooklyn, New York 11203, USA
    Endocrinology 144:4061-9. 2003
    ..These results indicate that hormones processed by PC2 affected processes that regulate islet cell differentiation and maturation in embryos and adults...
  101. ncbi Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase
    Dan Kawamori
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita City, Osaka, Japan
    Diabetes 52:2896-904. 2003
    ....

Research Grants8

  1. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
    ..abstract_text> ..
  2. Molecular Regulation of Pancreas Cell Fate Determination
    BEN STANGER; Fiscal Year: 2007
    ..Practically, an understanding of the mechanisms by which the organism specifies such cell types may confer the ability to experimentally manipulate tissues for therapy. ..
  3. Notch Signaling and Cell Fate in Embryonic and Adult Liver
    BEN STANGER; Fiscal Year: 2008
    ..As a first step, Notch signaling will be studied to understand how this essential signaling pathway functions during liver development and in the normal function of the liver. [unreadable] [unreadable]..
  4. Foxm 1b endocrine pancreas growth and regeneration
    Maureen Gannon; Fiscal Year: 2009
    ..A thorough understanding of Foxml regulation of 3 cell mass may lead to strategies for maintaining 3 cell mass and enhancing 3 cell proliferation in diabetics. ..
  5. GENETIC MECHANISMS OF HINDBRAIN SEGMENTATION
    Cecilia Moens; Fiscal Year: 2009
    ..Aim 2 addresses the mechanism of plasticity. Finally, in Aim 3, we consider the mechanism by which long-range signals interact to specify the positions of specific hindbrain boundaries. ..
  6. Mechanisms of endoderm specification along the A-P axis.
    James M Wells; Fiscal Year: 2010
    ..Additionally, this information should allow us to coax embryonic stem cells into becoming important transplantable derivatives of endoderm, such as insulin-producing beta cells to treat patients with Type 1 diabetes. ..
  7. Tilling the Zebrafish Genome: A Reverse Genetic Approach
    Lilianna Solnica Krezel; Fiscal Year: 2010
    ..We now propose to use TILLING to identify mutations in 120 genes that are of importance to biomedical research, and to make these mutants available to the zebrafish community as rapidly as possible. ..
  8. HNF6 Function in the Pancreatic Endocrine Lineage
    Maureen A Gannon; Fiscal Year: 2010
    ..e. is HNF6 needed only at early stages of endocrine specification, or is it required continuously during embryogenesis for terminal differentiation and acquisition of mature function. ..