Pdpk1

Summary

Gene Symbol: Pdpk1
Description: 3-phosphoinositide dependent protein kinase 1
Alias: Pdk1, 3-phosphoinositide-dependent protein kinase 1, Pkb kinase
Species: mouse

Top Publications

  1. ncbi Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta
    L Q Dong
    Department of Pharmacology, The University of Health Science Center, San Antonio, Texas 78284, USA
    J Biol Chem 274:8117-22. 1999
  2. pmc Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4
    Ajay Nirula
    Department of Medicine, The Rosalind Russell Medical Research Center for Arthritis and the Howard Hughes Medical Institute, University of California at San Francisco, CA 94143, USA
    J Exp Med 203:1733-44. 2006
  3. pmc The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells
    Sung Gyoo Park
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 10:158-66. 2009
  4. pmc Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
    Wenjing Zheng
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    EMBO Rep 11:890-5. 2010
  5. doi Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3)
    Véronique Mouton
    Université catholique de Louvain and de Duve Institute, 75 Avenue Hippocrate, Brussels, Belgium
    Biochem J 431:267-75. 2010
  6. ncbi Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1
    Neil E Torbett
    Protein Phosphorylation Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 278:32344-51. 2003
  7. doi The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation
    Sanae Haga
    Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Hepatology 49:204-14. 2009
  8. ncbi Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3
    Saori Sato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    J Biol Chem 277:39360-7. 2002
  9. pmc Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function
    Mei A Lim
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 100:14006-11. 2003
  10. pmc 3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium
    Grant R Budas
    Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    FASEB J 20:2556-8. 2006

Research Grants

  1. Adiponectin signaling and regulation
    Lily Dong; Fiscal Year: 2009

Scientific Experts

  • Jose R Bayascas
  • Hyunjung Ha
  • David K Finlay
  • Barry J Collins
  • Margaret A Lawlor
  • Luca Primo
  • Zhihui Xie
  • Edward J McManus
  • Lily Dong
  • Wataru Ogawa
  • Tetsuo Noda
  • Masato Kasuga
  • Dario R Alessi
  • Florian Lang
  • Rexhep Rexhepaj
  • Doreen A Cantrell
  • Hiroshi Sakaue
  • Heather J Hinton
  • Alfonso Mora
  • Hyun A Seong
  • Kristy Iskandar
  • April P Kelly
  • Akihiko Nishizawa
  • Wenjing Zheng
  • Feng Liu
  • Yasuo Okamoto
  • Naoko Hashimoto
  • Hiroshi Inoue
  • Ferruh Artunc
  • Yoshitake Hayashi
  • Michael J Wick
  • Hiroshi Itoh
  • Kenji Watatani
  • Jun Nakae
  • Yongheng Cao
  • Kui Liu
  • Deepak Adhikari
  • Anand Rotte
  • Changhua Wang
  • Teresa F Ackermann
  • Véronique Mouton
  • Kyoko Nakamura
  • Joaquim Grego-Bessa
  • Akihiko Takeda
  • Eijiro Watanabe
  • Yasushi Matsuki
  • Ramon A Riojas
  • Tianyuan Hu
  • Junghyun Noh
  • Florian Grahammer
  • Tinatin Zurashvili
  • Xue Chen
  • Stefan Eser
  • Kiyoshi Teshigawara
  • Mathea Pietri
  • Edina Schweighoffer
  • Grant R Budas
  • Kazuhito Tawaramoto
  • Jae Hyuck Shim
  • Yoshinaga Kawano
  • Anders Poulsen
  • Zhongzhou Yang
  • Katharine Ellwood-Yen
  • Andrew N Macintyre
  • Nagalingam R Sundaresan
  • Stephan Wullschleger
  • Meredith J Goertz
  • Haiyoung Jung
  • Jian Ping Guo
  • Charbel Darido
  • Albert Braeuning
  • Doreen Cantrell
  • Masanori Nakata
  • Yasuhiro Itoh
  • Toshihiko Yada
  • Yukiko Gotoh
  • Eisuke Takano
  • Zai Chang
  • Kazunori Nakajima
  • Ruo Min DI
  • Bhagirath Chaurasia
  • Nagaraju Gorre
  • Qiuting Feng
  • Jiangying Liu
  • Thomas A Masters
  • Yan Shen
  • Katherine J Fishwick
  • Ilpo Huhtaniemi
  • Tuula Hamalainen
  • Koji Oishi

Detail Information

Publications111 found, 100 shown here

  1. ncbi Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta
    L Q Dong
    Department of Pharmacology, The University of Health Science Center, San Antonio, Texas 78284, USA
    J Biol Chem 274:8117-22. 1999
    Phosphoinositide-dependent protein kinase-1 (PDK1) is a recently identified serine/threonine kinase that phosphorylates and activates Akt and p70(S6K), two downstream kinases of phosphatidylinositol 3-kinase...
  2. pmc Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4
    Ajay Nirula
    Department of Medicine, The Rosalind Russell Medical Research Center for Arthritis and the Howard Hughes Medical Institute, University of California at San Francisco, CA 94143, USA
    J Exp Med 203:1733-44. 2006
    ..We recently reported that phosphoinositide-dependent kinase 1 (PDK1) partially corrects the defect in IL-4 production present in CD28-deficient T cells, suggesting that PDK1 regulates ..
  3. pmc The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells
    Sung Gyoo Park
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 10:158-66. 2009
    ..We show here that phosphoinositide-dependent kinase 1 (PDK1) is essential for integrating the TCR and CD28 signals...
  4. pmc Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis
    Wenjing Zheng
    Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    EMBO Rep 11:890-5. 2010
    ..Our study identifies maternal phosphatidylinositol 3-kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice...
  5. doi Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3)
    Véronique Mouton
    Université catholique de Louvain and de Duve Institute, 75 Avenue Hippocrate, Brussels, Belgium
    Biochem J 431:267-75. 2010
    ..re-evaluated using different models: (i) hearts from transgenic mice with a muscle/heart-specific mutation in the PDK1 (phosphoinositide-dependent protein kinase 1)-substrate-docking site injected with insulin; (ii) hearts from PKBβ-..
  6. ncbi Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1
    Neil E Torbett
    Protein Phosphorylation Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    J Biol Chem 278:32344-51. 2003
    ..protein kinase C, has been shown to be under the control of Rho GTPases and 3-phosphoinositide-dependent kinase 1 (PDK1)...
  7. doi The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation
    Sanae Haga
    Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan
    Hepatology 49:204-14. 2009
    ..The current study was designed to investigate the roles of phosphoinositide-dependent protein kinase 1 (PDK1)-associated pathways in liver regeneration after partial hepatectomy (PH) using liver-specific Pdk1-knockout (L-..
  8. ncbi Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3
    Saori Sato
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113 0032, Japan
    J Biol Chem 277:39360-7. 2002
    3-Phosphoinositide-dependent protein kinase-1 (PDK1) plays a central role in activating the protein kinase A, G, and C subfamily...
  9. pmc Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function
    Mei A Lim
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 100:14006-11. 2003
    ....
  10. pmc 3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium
    Grant R Budas
    Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    FASEB J 20:2556-8. 2006
    ..3'-Phosphoinositide-dependent kinase-1 (PDK1) has been implicated in numerous cellular processes...
  11. pmc Essential role of PDK1 in regulating cell size and development in mice
    Margaret A Lawlor
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO J 21:3728-38. 2002
    b>PDK1 functions as a master kinase, phosphorylating and activating PKB/Akt, S6K and RSK...
  12. pmc Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia
    Alfonso Mora
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO J 22:4666-76. 2003
    We employed Cre/loxP technology to generate mPDK1(-/-) mice, which lack PDK1 in cardiac muscle...
  13. ncbi Transformation of mammary epithelial cells by 3-phosphoinositide- dependent protein kinase-1 activates beta-catenin and c-Myc, and down-regulates caveolin-1
    Zhihui Xie
    Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Res 63:5370-5. 2003
    3-phosphoinositide-dependent protein kinase-1 (PDK1) plays a pivotal role in coupling growth factor receptor signaling to tumor cell proliferation, survival, and invasion...
  14. ncbi The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development
    Heather J Hinton
    Lymphocyte Activation Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields, London WC2A 3PX, United Kingdom
    Nat Immunol 5:539-45. 2004
    ..these problems, we explored the consequences of genetic manipulation of phosphoinositide-dependent kinase 1 (PDK1), a rate-limiting 'upstream' activator of AGC kinases...
  15. pmc The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
    Edward J McManus
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee, UK
    EMBO J 23:2071-82. 2004
    We generated homozygous knockin ES cells expressing a form of 3-phosphoinositide-dependent protein kinase-1 (PDK1) with a mutation in its pleckstrin homology (PH) domain that abolishes phosphatidylinositol 3,4,5-tris-phosphate (PtdIns(3,4,..
  16. ncbi In vivo role of the phosphate groove of PDK1 defined by knockin mutation
    Barry J Collins
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dundee, DD1 5EH, UK
    J Cell Sci 118:5023-34. 2005
    ..activated following phosphorylation at their T-loop residue by the 3-phosphoinositide-dependent protein kinase-1 (PDK1)...
  17. ncbi Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice
    Jose R Bayascas
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Curr Biol 15:1839-46. 2005
    ..We explored the importance of PDK1, the protein kinase that activates PKB and S6K, in mediating tumorigenesis caused by the deletion of PTEN...
  18. pmc 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases
    Zhihui Xie
    Department of Oncology, Georgetown University School of Medicine, and Lombardi Comprehensive Cancer Center, Washington, DC, USA
    BMC Cancer 6:77. 2006
    ..b>PDK1 is a key molecule that couples PI3K to cell proliferation and survival signals in response to growth factor ..
  19. ncbi Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass
    Naoko Hashimoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Genet 38:589-93. 2006
    ..3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that mediates signaling downstream of PI 3-kinase...
  20. ncbi Fine tuning PDK1 activity by phosphorylation at Ser163
    Ramon A Riojas
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78229, USA
    J Biol Chem 281:21588-93. 2006
    3-Phosphoinositide-dependent protein kinase-1 (PDK1) mediates phosphorylation and activation of members of the AGC protein kinase family and plays an essential role in insulin signaling and action...
  21. ncbi Evaluation of approaches to generation of tissue-specific knock-in mice
    Jose R Bayascas
    MRC Protein Phosphorylation Unit and School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 281:28772-81. 2006
    ..to create tissue-specific knock-in mice by generating knock-in mice in which a substrate-docking site of the PDK1 protein kinase was ablated in Cre-expressing tissues in a way that prevented activation of one of its substrates, ..
  22. ncbi Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1
    Yasuo Okamoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan 657 0011
    Diabetes 56:1000-9. 2007
    Phosphoinositide-dependent kinase-1 (PDK1) is implicated in the metabolic effects of insulin as a key mediator of phosphoinositide 3-kinase-dependent signaling...
  23. pmc Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
    Jose R Bayascas
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    Mol Cell Biol 28:3258-72. 2008
    b>PDK1 activates a group of kinases, including protein kinase B (PKB)/Akt, p70 ribosomal S6 kinase (S6K), and serum and glucocorticoid-induced protein kinase (SGK), that mediate many of the effects of insulin as well as other agonists...
  24. doi PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response
    Bengt F Belgardt
    Institute for Genetics, Department of Mouse Genetics and Metabolism, Center for Molecular Medicine Cologne CMMC, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 7:291-301. 2008
    ..regulation, we have generated mice with selective inactivation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in POMC-expressing cells (PDK1(DeltaPOMC) mice)...
  25. doi PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles
    Pradeep Reddy
    Department of Medical Biochemistry and Biophysics, Umeå University SE 901 87, Umea, Sweden
    Hum Mol Genet 18:2813-24. 2009
    ..Here, we provide genetic evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) signaling in oocytes preserves reproductive lifespan by maintaining the survival of ovarian primordial follicles...
  26. pmc PDK1 coordinates survival pathways and beta-adrenergic response in the heart
    Kaoru Ito
    Department of Cardiovascular Science and, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Proc Natl Acad Sci U S A 106:8689-94. 2009
    The 3-phosphoinositide-dependent kinase-1 (PDK1) plays an important role in the regulation of cellular responses in multiple organs by mediating the phosphoinositide 3-kinase (PI3-K) signaling pathway through activating AGC kinases...
  27. pmc Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation
    Caryll Waugh
    Department of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 29:5952-62. 2009
    ..to the pleckstrin homology (PH) domain of the serine/threonine kinase 3-phosphoinositide-dependent kinase 1 (PDK1)...
  28. pmc Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes
    David K Finlay
    Division of Immunology and Cell Biology, University of Dundee, Dundee DD15EH, Scotland, UK
    J Exp Med 206:2441-54. 2009
    In normal T cell progenitors, phosphoinositide-dependent kinase l (PDK1)-mediated phosphorylation and activation of protein kinase B (PKB) is essential for the phosphorylation and inactivation of Foxo family transcription factors, and ..
  29. doi PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..PDK-1 and FoxO1 signaling in POMC neurons was responsible for energy homeostasis, we generated POMC neuron-specific Pdk1 knockout mice (POMCPdk1(-/-)) and mice selectively expressing a constitutively nuclear (CN)FoxO1 or transactivation-..
  30. ncbi PDK1 plays a critical role in regulating cardiac function in mice and human
    Ruo Min DI
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Chin Med J (Engl) 123:2358-63. 2010
    b>PDK1 is an essential protein kinase that plays a critical role in mammalian development. Mouse lacking PDK1 leads to multiple abnormalities and embryonic lethality at E9.5...
  31. pmc Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism
    Andrew N Macintyre
    College of Life Sciences, Division of Cell Biology and Immunology, University of Dundee, Scotland, UK
    Immunity 34:224-36. 2011
    ..Akt is thus dispensable for metabolism, but the strength and duration of Akt activity dictates the CTL transcriptional program and determines CTL fate...
  32. doi PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models
    Katharine Ellwood-Yen
    Merck Research Laboratories, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 71:3052-65. 2011
    b>PDK1 activates AKT suggesting that PDK1 inhibition might suppress tumor development. However, while PDK1 has been investigated intensively as an oncology target, selective inhibitors suitable for in vivo studies have remained elusive...
  33. pmc IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 286:37389-98. 2011
    ..IKBKE activation of Akt was not affected by inhibition of PI3K, knockdown of PDK1 or mTORC2 complex...
  34. pmc Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice
    Jae Hyuck Shim
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
    J Clin Invest 122:91-106. 2012
    ..Here, we report the identification of 3-phosphoinositide-dependent kinase 1 (PDK1) as a key regulator of CBP activity and demonstrate that its functions map to both osteoprogenitor cells and mature ..
  35. doi Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer
    Stefan Eser
    Department of Internal Medicine 2, Technische Universitat Munchen, Ismaningerstr 22, 81675 Munchen, Germany
    Cancer Cell 23:406-20. 2013
    ..We show that cell-autonomous phosphoinositide 3-kinase (PI3K) and 3-phosphoinositide-dependent protein kinase 1 (PDK1), but not Craf, are key effectors of oncogenic Kras in the pancreas, mediating cell plasticity, acinar-to-ductal ..
  36. pmc Regulation of novel protein kinase C epsilon by phosphorylation
    Vittoria Cenni
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    Biochem J 363:537-45. 2002
    ..However, the regulation of this phosphorylation is different for novel and conventional PKCs. Specifically, the phosphorylation of novel PKCs is regulated rather than constitutive...
  37. ncbi Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1
    Michael J Moore
    Howard Hughes Medical Institute and Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093 0654, USA
    J Biol Chem 277:47878-84. 2002
    ....
  38. pmc In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation
    Barry J Collins
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    EMBO J 22:4202-11. 2003
    ..and growth factors and are activated following phosphorylation by 3-phosphoinositide-dependent protein kinase-1 (PDK1)...
  39. ncbi 3-phosphoinositide-dependent protein kinase-1 activates the peroxisome proliferator-activated receptor-gamma and promotes adipocyte differentiation
    Yuzhi Yin
    Georgetown University School of Medicine, Washington, D C 20007, USA
    Mol Endocrinol 20:268-78. 2006
    ..3-phosphoinositide-dependent protein kinase-1 (PDK1) serves as a critical regulatory point in insulin signaling through its ability to phosphorylate the activation ..
  40. ncbi Phosphoinositide-dependent kinase l (PDK1) haplo-insufficiency inhibits production of alpha/beta (alpha/beta) but not gamma delta (gamma/delta) T lymphocytes
    April P Kelly
    Division of Cell Biology and Immunology, School of Life Sciences, WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 580:2135-40. 2006
    In the present study, we have explored the impact of deleting a single allele of PDK1 in T cell progenitors on alpha/beta and gamma/delta T cell development...
  41. ncbi Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
    ..These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production...
  42. ncbi Antigen receptor regulation of phosphoinositide-dependent kinase 1 pathways during thymocyte development
    Heather J Hinton
    Division of Cell Biology and Immunology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK
    FEBS Lett 580:5845-50. 2006
    Phosphoinositide-dependent kinase 1 (PDK1) is essential for T cell development but little is know about the stimuli that regulate PDK1 signaling in vivo...
  43. pmc Notch-induced T cell development requires phosphoinositide-dependent kinase 1
    April P Kelly
    College of Life Science, Division of Cell Biology and Immunology, MSI WTB complex, University of Dundee, Dundee, UK
    EMBO J 26:3441-50. 2007
    Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK)...
  44. pmc miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells
    Abdelfattah El Ouaamari
    Institut National de la Sante et de la Recherche Medicale, U907, Nice, France
    Diabetes 57:2708-17. 2008
    ..pancreas-specific miR-375 as a potential regulator of its predicted target 3'-phosphoinositide-dependent protein kinase-1 (PDK1), and we analyzed its implication in the response of insulin-producing cells to elevation of glucose levels.
  45. ncbi Mouse 3-phosphoinositide-dependent protein kinase-1 undergoes dimerization and trans-phosphorylation in the activation loop
    Michael J Wick
    Departments of Pharmacology, Biochemistry, and Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 278:42913-9. 2003
    ..together, our results show that mPDK1 autophosphorylation occurs at multiple sites through both cis and trans mechanisms and suggest that dimerization and trans-phosphorylation may serve as mechanisms to regulate PDK1 activity in cells.
  46. ncbi Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells
    Mei Ann Lim
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Oncogene 23:9348-58. 2004
    ..Our findings suggest that PDK-1/Akt signaling pathway plays a major role in regulating cell migration induced by PTEN deficiency...
  47. pmc Essential role of PDK1 in regulating endothelial cell migration
    Luca Primo
    Department of Oncological Sciences, University of Torino, 10060 Candiolo, Italy
    J Cell Biol 176:1035-47. 2007
    The serine/threonine protein kinase phosphoinositide-dependent kinase 1 (PDK1) plays a central role in cellular signaling by phosphorylating members of the AGC family of kinases, including PKB/Akt...
  48. pmc Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells
    Tanja Tamguney
    UCSF Cancer Research Institute, USA
    Exp Cell Res 314:2299-312. 2008
    3-phosphoinositide-dependent kinase-1 (PDK1) phosphorylates and activates several kinases in the cAMP-dependent, cGMP-dependent and protein kinase C (AGC) family...
  49. doi Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling
    Ying Zhang
    Institute of Physiology, University of Tubingen, Gmelinstrasse 5, D 72076 Tubingen, Germany
    FEBS Lett 583:3101-6. 2009
    ..hyperpolarization is modified by phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositide-dependent kinase PDK1. Perforated patch-clamp was performed in islet cells isolated from PDK1 hypomorphic mice (pdk1(fl/fl)), expressing ..
  50. doi PI3 kinase and PDK1 in the regulation of the electrogenic intestinal dipeptide transport
    Rexhep Rexhepaj
    Department of Physiology, University of Tubingen, 72076 Tubingen, Germany
    Cell Physiol Biochem 25:715-22. 2010
    The phosphoinositol 3 kinase (PI3K) and the phosphoinositide dependent kinase (PDK1) stimulate the serum and glucocorticoid inducible kinase (SGK) and protein kinase B (PKB/Akt) isoforms, kinases stimulating a variety of transporters...
  51. pmc Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages
    Bhagirath Chaurasia
    Institute for Genetics, Department of Mouse Genetics and Metabolism, University of Cologne, Cologne, Germany
    Mol Cell Biol 30:4354-66. 2010
    ..These experiments reveal a novel PDK-1-dependent negative feedback inhibition of TLR-induced NF-kappaB activation in macrophages in vivo...
  52. doi Regulation of 3-phosphoinositide-dependent protein kinase 1 activity by homodimerization in live cells
    Thomas A Masters
    Cell Biophysics Laboratory, Cancer Research UK, London WC2A 3LY, UK
    Sci Signal 3:ra78. 2010
    3-Phosphoinositide-dependent kinase 1 (PDK1) plays a central role in regulating the activity of protein kinases that are essential for signaling; however, how PDK1 itself is regulated is largely unknown...
  53. pmc Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1
    Jiangying Liu
    Institute for Diabetes, Obesity, and Metabolism and the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:20494-9. 2010
    ..We further identify the 3-phosphoinositide-dependent protein kinase 1 (PDK1), a well-known kinase involved in the PI3K-Akt signaling pathway, as a direct Meis3 target, which mediates its role ..
  54. doi Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis
    Charbel Darido
    Department of Medicine, Monash University Central Clinical School, Prahran, Victoria 3181, Australia
    Cancer Cell 20:635-48. 2011
    ..Our data define the GRHL3-PTEN axis as a critical tumor suppressor pathway in SCC...
  55. doi PDK1 regulates the generation of oligodendrocyte precursor cells at an early stage of mouse telencephalic development
    Kenji Watatani
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 0032, Japan
    Genes Cells 17:326-35. 2012
    ..Here, we show that the serine-threonine kinase 3-phosphoinositide-dependent kinase 1 (PDK1) contributes to an early wave of OPC production in the developing mouse telencephalon...
  56. pmc Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival
    Tinatin Zurashvili
    Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    Mol Cell Biol 33:1027-40. 2013
    3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, ..
  57. doi PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases
    Mathea Pietri
    1 Institut National de la Santé et de la Recherche Médicale INSERM, UMR S 747, Paris, France 2 Université Paris Descartes, Sorbonne Paris Cité, UMR S 747, Paris, France
    Nat Med 19:1124-31. 2013
    ..3-phosphoinositide-dependent kinase-1 (PDK1) activity is increased in neurons infected with prions or affected by Aβ deposition and in the brains of ..
  58. doi Phosphoinositide-dependent kinase 1 regulates leukemia stem cell maintenance in MLL-AF9-induced murine acute myeloid leukemia
    Tianyuan Hu
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China
    Biochem Biophys Res Commun 459:692-8. 2015
    ..Phosphoinositide-dependent kinase 1 (PDK1) is a critical regulator of the PI3K/Akt pathway and has been shown to be frequently activated in leukemia...
  59. pmc Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations
    Junghyun Noh
    Program in Molecular Medicine and Division of Endocrinology, Metabolism and Diabetes, University of Utah School of Medicine, Salt Lake City, UT 84112, USA Division of Endocrinology and Metabolism, College of Medicine, Inje University, Goyang, South Korea
    J Mol Cell Cardiol 89:297-305. 2015
    Phosphoinositide-dependent protein kinase-1 (PDPK1) is an important mediator of phosphatidylinositol 3-kinase (PI3K) signaling...
  60. pmc The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium
    Joaquim Grego-Bessa
    Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, United States
    elife 5:e12034. 2016
    ..The Pten phenotype is mimicked by constitutive activation of PI3 kinase and is rescued by the removal of PDK1 (PDPK1), but does not depend on the downstream kinases AKT and mTORC1...
  61. pmc Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis
    Heather K Bone
    Department of Pharmacy and Pharmacology, Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    J Cell Sci 120:1752-62. 2007
    ..signalling demonstrate that PI3K-mediated signals, most likely via 3-phosphoinositide-dependent protein kinase 1 (PDK1), are required for proliferation of cells within developing embryoid bodies (EBs)...
  62. pmc PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    Yongheng Cao
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    PLoS ONE 6:e18324. 2011
    ..synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1)...
  63. doi Gender-specific interplay of signaling through β-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation
    Albert Braeuning
    Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tubingen, 72074 Tubingen, Germany
    Toxicol Sci 123:113-22. 2011
    ..dependent on estrogen signaling and was associated with enhanced expression of FoxM1 and elevated activity of the PDK1/p90RSK pathway...
  64. doi The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
    Nagalingam R Sundaresan
    Department of Surgery, Committee on Cellular and Molecular Physiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Sci Signal 4:ra46. 2011
    ..PIP(3)), which promotes membrane localization and phosphorylation of Akt by the upstream kinase PDK1 (phosphoinositide-dependent protein kinase 1)...
  65. doi Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis
    Kazuhito Tawaramoto
    Division of Diabetes, Endocrinology, and Metabolism, Kawasaki Medical School, Okayama 701 0192, Japan
    Mol Endocrinol 26:95-109. 2012
    ..In this study, we addressed the precise role of the 3-phosphoinositide-dependent protein kinase 1 (PDK1)-regulated signaling network in endothelial cells in vivo, using vascular endothelial PDK1 knockout (VEPDK1KO) mice...
  66. doi Structure-based design of PDK1 inhibitors
    Anders Poulsen
    S BIO Pte Ltd, 1 Science Park Road, 05 09 The Capricorn, Singapore Science Park II, Singapore 117528, Singapore
    Bioorg Med Chem Lett 22:305-7. 2012
    A macrocyclic 2-anilino-4-phenyl-pyrimidine CDK/Flt3/JAK2 inhibitor was found to have moderate PDK1 activity...
  67. pmc PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity
    Hyun A Seong
    Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 287:20811-22. 2012
    ..In this study, MPK38-induced PDK1 phosphorylation was examined to elucidate the biochemical mechanisms underlying phosphorylation-dependent ..
  68. pmc Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance
    Yoshinaga Kawano
    Frontier Medicine on Metabolic Syndrome, Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Diabetes 61:1935-48. 2012
    ..The 3-phosphoinositide-dependent protein kinase 1 (Pdk1)/forkhead transcription factor (Foxo1) pathway is important in regulating glucose and energy homeostasis, but ..
  69. pmc The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway
    Edina Schweighoffer
    Division of Immune Cell Biology, MRC National Institute for Medical Research, London NW7 1AA, UK
    Immunity 38:475-88. 2013
    ....
  70. pmc Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt
    Ingrid Remy
    Departement de Biochimie, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    Mol Cell Biol 24:1493-504. 2004
    ..enhancing the phosphorylation of both of its regulatory sites by promoting its interaction with the upstream kinase PDK1. Further, the modulation of PKB activity by Ft1 has a strong effect on the apoptosis susceptibility of T ..
  71. pmc Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells
    Ellen Weisberg
    Department of Medical Oncology Hematologic Neoplasia, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 111:3723-34. 2008
    ..Finally, BAG956 and rapamycin/RAD001 were shown to combine in a nonantagonistic fashion against BCR-ABL- and mutant FLT3-expressing cells both in vitro and in vivo...
  72. doi PDK1 regulates platelet activation and arterial thrombosis
    Xue Chen
    Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai, China
    Blood 121:3718-26. 2013
    The effects of phosphoinositide-dependent protein kinase 1 (PDK1), a master kinase in the phosphoinositide 3-kinase/Akt pathway, on platelet activation are unknown...
  73. ncbi Substitution of the autophosphorylation site Thr516 with a negatively charged residue confers constitutive activity to mouse 3-phosphoinositide-dependent protein kinase-1 in cells
    Michael J Wick
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 277:16632-8. 2002
    ..Taken together, our results suggest that mPDK-1 undergoes autophosphorylation at multiple sites and that this phosphorylation may be essential for PDK-1 to interact with and phosphorylate its downstream substrates in vivo...
  74. ncbi Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes
    Tetsuya Yamada
    Division of Molecular Metabolism and Diabetes, Department of Internal Medicine, Tohoku University Graduate School of Medicine, Sendai, 980 8574, Japan
    Am J Physiol Endocrinol Metab 282:E1385-94. 2002
    To investigate the role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in the insulin-signaling pathway for glucose metabolism, wild-type (wt), the kinase-dead (kd), or the plecstrin homology (PH) domain deletion (DeltaPH) mutant ..
  75. ncbi Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta
    Lily Q Dong
    Department of Pharmacology, The University of Texas Health Science Center, San Antonio, TX 78229, USA
    Biochem Biophys Res Commun 294:136-44. 2002
    ..The specific expression of mPDK-1 beta in mouse testis and brains of aged mice also suggests potential involvement of this kinase in regulating animal spermatogenesis and aging...
  76. ncbi The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism
    Constantin Makris
    Institut de Recherches Cliniques de Montréal and Department of Pharmacology, University of Montreal, 110 Pine Avenue West, Montreal, Quebec H2W 1R7, Canada
    Oncogene 21:7891-6. 2002
    ..kinases Akt1 and p70 S6 kinase (S6K1), two downstream targets of phosphoinositide-dependent kinase 1 (PDK1)...
  77. ncbi Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17
    Syuichi Koarada
    Division of Rheumatology and Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Immunogenetics 56:333-7. 2004
    ..However, using NOD MHC congenic mice, we demonstrate that the MHC region is excluded, and that NOD peripheral lymphocytosis is controlled by genetic intervals adjacent to the MHC region on Chr 17...
  78. ncbi Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene
    U K Misra
    Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Biochem 93:1020-32. 2004
    ..We conclude that in murine peritoneal macrophages, alpha2M*-induced increase of cAMP is involved in cellular proliferation and this process is mediated by the PI 3-kinase signaling cascade...
  79. pmc Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure
    Alfonso Mora
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 385:639-48. 2005
    The liver plays an important role in insulin-regulated glucose homoeostasis. To study the function of the PDK1 (3-phosphoinositide-dependent protein kinase-1) signalling pathway in mediating insulin's actions in the liver, we employed CRE ..
  80. pmc RGS4 and RGS5 are in vivo substrates of the N-end rule pathway
    Min Jae Lee
    Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 102:15030-5. 2005
    ....
  81. pmc Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta
    Karim Nadra
    Center for Integrative Genomics, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:3266-81. 2006
    ..Altogether, this important role of PPARbeta/delta in placenta development and giant cell differentiation should be considered when contemplating the potency of PPARbeta/delta agonist as therapeutic agents of broad application...
  82. ncbi Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice
    Rexhep Rexhepaj
    Department of Physiology I, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    FASEB J 20:2214-22. 2006
    The phosphoinositide-dependent kinase PDK1 activates the serum- and glucocorticoid-inducible kinase isoforms SGK1, SGK2, and SGK3 and protein kinase B, which in turn are known to up-regulate a variety of sodium-coupled transporters...
  83. ncbi Parvovirus interference with intracellular signalling: mechanism of PKCeta activation in MVM-infected A9 fibroblasts
    Sylvie Lachmann
    Program Infection and Cancer, Abteilung F010 and Institut National de la Santé et de la Recherche Médicale U701, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cell Microbiol 10:755-69. 2008
    ..The activity, subcellular localization and phosphorylation status of the protein kinases PDK1, PKCeta and PKClambda were measured in A9 cells in the presence or absence of MVM infection...
  84. doi Role of PDK1 in regulation of gastric acid secretion
    Anand Rotte
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 22:725-34. 2008
    ..Signaling of PI-3-kinase includes activation of the phosphoinositide dependent kinase PDK1. We thus hypothesized that PDK1 may influence gastric acid secretion...
  85. ncbi Pancreatic beta cell mass preserved in heterozygous PDK1 knockout mice
    Akihiko Takeda
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 17, Japan
    Kobe J Med Sci 54:E183-90. 2008
    We have demonstrated that 3-phosphoinositide-dependent protein kinase 1 (PDK1) contributes to signaling by insulin or insulin-like growth factor-1 (IGF-1) that is responsible for the regulation of both the number and size of pancreatic ..
  86. doi HMGB1 is phosphorylated by classical protein kinase C and is secreted by a calcium-dependent mechanism
    Young Joo Oh
    Department of Microbiology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
    J Immunol 182:5800-9. 2009
    ....
  87. pmc A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1
    Olga C Rodriguez
    Departments of Oncology and Pathology, Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington, DC 20057, USA
    Am J Pathol 174:2051-60. 2009
    ..Activation of mTOR was not seen. Our data demonstrates that Pten functions downstream of ErbB-2 to restrict prostate epithelial transformation by blocking full activation of the PDK1 signaling cascade.
  88. pmc Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles
    Deepak Adhikari
    1Department of Medical Biochemistry and Biophysics, Umea University, Umea, Sweden
    Hum Mol Genet 19:397-410. 2010
    ..Deregulation of these signaling pathways in oocytes results in pathological conditions of the ovary, including POF and infertility...
  89. pmc Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation
    Hyun A Seong
    Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361 763, Republic of Korea
    J Biol Chem 285:2397-414. 2010
    ..In this study, we reveal a functional association between PDK1 (3-phosphoinositide-dependent protein kinase 1), a critical mediator of cell survival, and ASK1 (apoptosis signal-..
  90. doi Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tube
    Katherine J Fishwick
    Neural Development Group, Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK
    Dev Biol 338:215-25. 2010
    ..Here we show that mutant mice lacking PKB activity downstream of PDK1, the master kinase of the PI3-kinase pathway, exhibit deficient neuron production...
  91. pmc PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development
    Qiuting Feng
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Mol Cell Biol 30:3711-21. 2010
    ..VEGFR) and the Tie2 receptor, is the phosphoinositide-3 kinase (PI3K)-phosphoinositide-dependent protein kinase 1 (PDK1)-Akt/protein kinase B (PKB) cascade that plays a critical role in development and tumorigenesis...
  92. pmc Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells
    David K Finlay
    Division of Cell Biology and Immunology, University of Dundee, Dundee, United Kingdom
    J Immunol 185:5973-82. 2010
    ..study uses two independent genetic strategies to explore the requirement for phosphoinositide-dependent kinase-1 (PDK1) in the development of mature T cell populations from CD4/CD8 double-positive thymocytes...
  93. pmc How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance
    Stephan Wullschleger
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Dis Model Mech 4:95-103. 2011
    ..Using insulin-resistant PDK1(K465E/K465E) PH domain knock-in mice, we found that introducing the PTEN(+/-) mutation to slightly stimulate Akt ..
  94. pmc Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis
    Meredith J Goertz
    Department of Pathology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9072, USA
    J Clin Invest 121:3456-66. 2011
    ..By conditional inactivation of 3-phosphoinositide-dependent protein kinase 1 (Pdk1) and phosphatase and tensin homolog (Pten) in the male germ line, we found that PI3K signaling regulates Foxo1 ..
  95. ncbi Expression cloning of protein targets for 3-phosphorylated phosphoinositides
    V R Rao
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:37893-900. 1999
    ..This report demonstrates the utility of this technique for isolating and characterizing 3'-PPI-binding proteins and has broad applicability for the isolation of binding domains for other lipid products...
  96. ncbi Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes
    Hiroshi Sakaue
    Division of Diabetes and Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 278:38870-4. 2003
    ..These results indicate that PDK-1 is essential for insulin-induced glucose uptake in adipocytes...
  97. ncbi Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart
    Alfonso Mora
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    FEBS Lett 579:3632-8. 2005
    In order to investigate the importance of the PDK1-PKB-GSK3 signalling network in regulating glycogen synthase (GS) in the heart, we have employed tissue specific conditional knockout mice lacking PDK1 in muscle (mPDK1-/-), as well as ..
  98. pmc Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling
    Francesca Fiory
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Italy
    Mol Cell Biol 25:10803-14. 2005
    ..In L6 cells expressing IR(WT), the C-terminal peptide also impaired insulin-dependent PDK-1 membrane persistence. Thus, PDK-1 directly binds to the insulin receptor, followed by PDK-1 activation and insulin metabolic effects...
  99. ncbi Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice
    Ferruh Artunc
    Dept of Physiology, Univ of Tübingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Regul Integr Comp Physiol 291:R1533-8. 2006
    ..The experiments disclose a novel element of glucose transport regulation in kidney and small intestine...
  100. ncbi Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse
    Ciprian Sandu
    Department of Physiology I, University of Tubingen, Germany
    Am J Physiol Gastrointest Liver Physiol 291:G868-76. 2006
    ..The present study was performed to explore the role of PDK1 in the regulation of NHE3 activity...
  101. ncbi Fused protein of deltaPKC activation loop and PDK1-interacting fragment (deltaAL-PIF) functions as a pseudosubstrate and an inhibitory molecule for PDK1 when expressed in cells
    Takahiro Seki
    Department of Molecular and Pharmacological Neuroscience, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Genes Cells 11:1051-70. 2006
    To elucidate the role of 3-phosphoinositide-dependent protein kinase-1 (PDK1) in cellular signaling, we constructed and expressed a pseudosubstrate of PDK1, designated as deltaAL-PIF, and characterized its properties in cultured cells...

Research Grants1

  1. Adiponectin signaling and regulation
    Lily Dong; Fiscal Year: 2009
    ..abstract_text> ..