Pdk1

Summary

Gene Symbol: Pdk1
Description: pyruvate dehydrogenase kinase, isoenzyme 1
Alias: B830012B01, D530020C15Rik, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial, pyruvate dehydrogenase kinase, isozyme 1, PDH kinase 1, [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial
Species: mouse

Top Publications

  1. ncbi Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice
    Jose R Bayascas
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Curr Biol 15:1839-46. 2005
  2. doi PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles
    Pradeep Reddy
    Department of Medical Biochemistry and Biophysics, Umeå University SE 901 87, Umea, Sweden
    Hum Mol Genet 18:2813-24. 2009
  3. doi Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation
    Cossette Sanchez Canedo
    Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Endocrinol Metab 298:E761-9. 2010
  4. ncbi PDK1 plays a critical role in regulating cardiac function in mice and human
    Ruo Min DI
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Chin Med J (Engl) 123:2358-63. 2010
  5. pmc IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 286:37389-98. 2011
  6. doi PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response
    Bengt F Belgardt
    Institute for Genetics, Department of Mouse Genetics and Metabolism, Center for Molecular Medicine Cologne CMMC, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 7:291-301. 2008
  7. ncbi Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass
    Naoko Hashimoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Genet 38:589-93. 2006
  8. doi PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
  9. pmc Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation
    Caryll Waugh
    Department of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 29:5952-62. 2009
  10. ncbi Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1
    Yasuo Okamoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan 657 0011
    Diabetes 56:1000-9. 2007

Scientific Experts

  • Luca Primo
  • Jose R Bayascas
  • Wataru Ogawa
  • Tetsuo Noda
  • Masato Kasuga
  • Sung Gyoo Park
  • Zhongzhou Yang
  • Dario R Alessi
  • Yasuhiro Itoh
  • Akihiko Nishizawa
  • Kazunori Nakajima
  • Koji Oishi
  • Ruomin Di
  • Zai Chang
  • Yongheng Cao
  • Matthew S Hayden
  • Qiuting Feng
  • Sankar Ghosh
  • Kristy Iskandar
  • Florian Lang
  • Y Zheng
  • Stephanie Bonney
  • Irina I Nagy
  • Naoko Hashimoto
  • Yasushi Matsuki
  • Eijiro Watanabe
  • Zhonglin Han
  • Yasuo Okamoto
  • Zheng Tan
  • Paul Childress
  • Xiaojing Hou
  • Hiroshi Inoue
  • A Tsuchiya
  • M Scortegagna
  • Tinatin Zurashvili
  • Yonghan He
  • Xue Chen
  • Hui Xin Liu
  • Mathea Pietri
  • Yukiko Gotoh
  • Meixiao Long
  • Taro Hitosugi
  • Stephan Wullschleger
  • Qing Luan
  • Xinli Li
  • Shuangshuang Lu
  • Albert Braeuning
  • Marion Hölscher
  • Andrew N Macintyre
  • Emily C Dunford
  • Nagalingam R Sundaresan
  • Jian Ping Guo
  • Toshihiko Yada
  • Yoshitake Hayashi
  • Eisuke Takano
  • Masanori Nakata
  • Jun Nakae
  • Hiroshi Itoh
  • Cossette Sanchez Canedo
  • Bixi Jian
  • Ruo Min DI
  • David Finlay
  • Jiangying Liu
  • Caryll Waugh
  • Kalani L Raphael
  • Shuhua Xia
  • Olga C Rodriguez
  • Nader Chalhoub
  • Ying Zhang
  • Pradeep Reddy
  • Brian A Hemmings
  • Ellen Weisberg
  • Zoe Moon
  • Kyoko Nakamura
  • Lorenzo Battini
  • Michael Foller
  • Bengt F Belgardt
  • Hiroshi Sakaue
  • Heather K Bone
  • Kiyoshi Teshigawara
  • Ryuji Hiramatsu
  • Hitoshi Okamura
  • Ramon A Riojas
  • Rexhep Rexhepaj
  • Jung whan Kim
  • Yuichi Tominaga
  • Nicolas Di-Poï
  • Alfonso Mora
  • Ingrid Remy
  • W Yuan

Detail Information

Publications64

  1. ncbi Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice
    Jose R Bayascas
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Curr Biol 15:1839-46. 2005
    ..We explored the importance of PDK1, the protein kinase that activates PKB and S6K, in mediating tumorigenesis caused by the deletion of PTEN...
  2. doi PDK1 signaling in oocytes controls reproductive aging and lifespan by manipulating the survival of primordial follicles
    Pradeep Reddy
    Department of Medical Biochemistry and Biophysics, Umeå University SE 901 87, Umea, Sweden
    Hum Mol Genet 18:2813-24. 2009
    ..Here, we provide genetic evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) signaling in oocytes preserves reproductive lifespan by maintaining the survival of ovarian primordial follicles...
  3. doi Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation
    Cossette Sanchez Canedo
    Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Endocrinol Metab 298:E761-9. 2010
    ..via the canonical association of phosphatidylinositol 3-kinase (PI3K), phosphoinositide-dependent protein kinase-1 (PDK1), and protein kinase B (PKB/Akt)...
  4. ncbi PDK1 plays a critical role in regulating cardiac function in mice and human
    Ruo Min DI
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Chin Med J (Engl) 123:2358-63. 2010
    b>PDK1 is an essential protein kinase that plays a critical role in mammalian development. Mouse lacking PDK1 leads to multiple abnormalities and embryonic lethality at E9.5...
  5. pmc IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 286:37389-98. 2011
    ..IKBKE activation of Akt was not affected by inhibition of PI3K, knockdown of PDK1 or mTORC2 complex...
  6. doi PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response
    Bengt F Belgardt
    Institute for Genetics, Department of Mouse Genetics and Metabolism, Center for Molecular Medicine Cologne CMMC, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 7:291-301. 2008
    ..regulation, we have generated mice with selective inactivation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in POMC-expressing cells (PDK1(DeltaPOMC) mice)...
  7. ncbi Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass
    Naoko Hashimoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Genet 38:589-93. 2006
    ..3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that mediates signaling downstream of PI 3-kinase...
  8. doi PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake
    Kristy Iskandar
    International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    Am J Physiol Endocrinol Metab 298:E787-98. 2010
    ..PDK-1 and FoxO1 signaling in POMC neurons was responsible for energy homeostasis, we generated POMC neuron-specific Pdk1 knockout mice (POMCPdk1(-/-)) and mice selectively expressing a constitutively nuclear (CN)FoxO1 or transactivation-..
  9. pmc Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation
    Caryll Waugh
    Department of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 29:5952-62. 2009
    ..to the pleckstrin homology (PH) domain of the serine/threonine kinase 3-phosphoinositide-dependent kinase 1 (PDK1)...
  10. ncbi Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1
    Yasuo Okamoto
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe, Japan 657 0011
    Diabetes 56:1000-9. 2007
    Phosphoinositide-dependent kinase-1 (PDK1) is implicated in the metabolic effects of insulin as a key mediator of phosphoinositide 3-kinase-dependent signaling...
  11. pmc Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
    Jose R Bayascas
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    Mol Cell Biol 28:3258-72. 2008
    b>PDK1 activates a group of kinases, including protein kinase B (PKB)/Akt, p70 ribosomal S6 kinase (S6K), and serum and glucocorticoid-induced protein kinase (SGK), that mediate many of the effects of insulin as well as other agonists...
  12. pmc The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells
    Sung Gyoo Park
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 10:158-66. 2009
    ..We show here that phosphoinositide-dependent kinase 1 (PDK1) is essential for integrating the TCR and CD28 signals...
  13. ncbi Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
    ..These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production...
  14. pmc Loss of polycystin-1 causes centrosome amplification and genomic instability
    Lorenzo Battini
    Division of Renal Medicine, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1243 New York, NY 10029, USA
    Hum Mol Genet 17:2819-33. 2008
    ..These findings establish a novel function of PC1 in ADPKD pathogenesis and a genetic mechanism that may underlie the intrafamilial variability of ADPKD progression...
  15. pmc PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway
    A Tsuchiya
    Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya 663 8501, Japan
    J Endocrinol 220:49-59. 2014
    ..by the phosphoinositide 3 kinase (PI3K) inhibitor wortmannin, the 3-phosphoinositide-dependent protein kinase 1 (PDK1) inhibitor BX912 or the Akt1/2 inhibitor MK2206, and by knocking-down PI3K, PDK1 or Akt1/2...
  16. pmc Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma
    M Scortegagna
    Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Oncogene 33:4330-9. 2014
    Phosphoinositide-dependent kinase-1 (PDK1) is a serine/threonine protein kinase that phosphorylates members of the conserved AGC kinase superfamily, including AKT and protein kinase C (PKC), and is implicated in important cellular ..
  17. pmc PPARβ Regulates Liver Regeneration by Modulating Akt and E2f Signaling
    Hui Xin Liu
    Department of Medical Pathology and Laboratory Medicine, University of California, Sacramento, California, United States of America
    PLoS ONE 8:e65644. 2013
    ..delayed liver regeneration in KO mice was accompanied by lack of activation of phosphoinositide-dependent kinase 1 (PDK1)/Akt...
  18. pmc Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
    Taro Hitosugi
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 44:864-77. 2011
    ..Together, tyrosine phosphorylation activates PDHK1 to promote the Warburg effect and tumor growth...
  19. doi PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation
    Emily C Dunford
    Centre for Muscle Metabolism and Biophysics, Brock University, St Catharines, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 300:R1487-93. 2011
    ..PDH is deactivated by a set of PDH kinases (PDK1, PDK2, PDK3, PDK4), with PDK2 and PDK4 being the most predominant isoforms in skeletal muscle...
  20. pmc Impairment of Wnt11 function leads to kidney tubular abnormalities and secondary glomerular cystogenesis
    Irina I Nagy
    Biocenter Oulu, Laboratory of Developmental Biology, Faculty of Biochemistry and Molecular Medicine, Oulu Center for Cell Matrix Research, University of Oulu, Aapistie 5A, Oulu, 90014, Finland
    BMC Dev Biol 16:30. 2016
    ..The presence of Wnt11 in the emerging tubular system suggests that it may have certain roles later in the development of the epithelial ductal system...
  21. pmc Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells
    Ellen Weisberg
    Department of Medical Oncology Hematologic Neoplasia, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Blood 111:3723-34. 2008
    ..Finally, BAG956 and rapamycin/RAD001 were shown to combine in a nonantagonistic fashion against BCR-ABL- and mutant FLT3-expressing cells both in vitro and in vivo...
  22. pmc Deletion of PDK1 causes cardiac sodium current reduction in mice
    Zhonglin Han
    Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    PLoS ONE 10:e0122436. 2015
    The AGC protein kinase family regulates multiple cellular functions. 3-phosphoinositide-dependent protein kinase-1 (PDK1) is involved in the pathogenesis of arrhythmia, and its downstream factor, Forkhead box O1 (Foxo1), negatively ..
  23. pmc Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism
    Zheng Tan
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China
    J Immunol 194:6082-9. 2015
    ..In this study, we found that pyruvate dehydrogenase kinase 1 (PDK1), a key regulatory enzyme in glucose metabolism, plays an important role in the differential activation of ..
  24. pmc Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation
    Xiaojing Hou
    State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China
    J Cell Sci 128:2319-29. 2015
    ..Here, by undertaking knockdown and overexpression analysis of PDK paralogs (PDK1-PDK4) in mouse oocytes, we established the site-specificity of PDKs towards the phosphorylation of three serine ..
  25. pmc Diverse Functions of Retinoic Acid in Brain Vascular Development
    Stephanie Bonney
    Department of Pediatrics, Section of Developmental Biology, University of Colorado, School of Medicine Anschutz Medical Campus Aurora, Colorado 80045
    J Neurosci 36:7786-801. 2016
    ..From this, a model emerges in which RA acts upstream of the WNT pathway via non-cell-autonomous and cell-autonomous mechanisms to ensure the formation of an adequate and stable brain vascular plexus...
  26. pmc Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis
    Paul Childress
    Department of Anatomy and Cell Biology P C, S H B, D H, A G R, M R A, J P B, Indiana University School of Medicine, Indianapolis, Indiana 46202 Lilly Research Laboratories K R S, J K M, Z R G, V K, Eli Lilly and Company, Indianapolis, Indiana 46202 Orthopaedic Surgery M B A, Indiana University School of Medicine Department of Medical and Molecular Genetics Z W, Y S, Y L, J P B, Indiana University School of Medicine Center for Computational Biology and Bioinformatics Z W, Y L, Indiana University School of Medicine Department of Pediatrics Y H, F C Y, Indiana University School of Medicine Herman B Wells Center for Pediatric Research Y H, F C Y Cellular and Integrative Physiology F M P Center for Translational Musculoskeletal Research S J W, School of Health and Rehabilitation Sciences, Indiana University and Department of Physical Therapy S J W, School of Health and Rehabilitation Sciences, Indiana University, Indianapolis, Indiana 46202
    Mol Endocrinol 29:1269-85. 2015
    ..These data suggest that Nmp4 suppresses bone anabolism, in part, by regulating IGF-binding protein expression. Changes in Nmp4 status may lead to improvements in osteoprogenitor response to therapeutic cues. ..
  27. pmc PDK1-Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex
    Yasuhiro Itoh
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 113:E2955-64. 2016
    ..We now show that the serine/threonine kinase Akt and its activator phosphoinositide-dependent protein kinase 1 (PDK1) regulate the speed of locomotion of mouse neocortical neurons through the cortical plate...
  28. doi Loss of Dnmt3b accelerates MLL-AF9 leukemia progression
    Y Zheng
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
    Leukemia 30:2373-2384. 2016
    ..Taken together, these results demonstrate that Dnmt3b plays a tumor suppressive role in MLL-AF9 AML progression, thereby providing new insights into the roles of DNA methylation in leukemia development...
  29. ncbi HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    Jung whan Kim
    Graduate Program of Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Metab 3:177-85. 2006
    ..the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA...
  30. doi PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases
    Mathea Pietri
    1 Institut National de la Santé et de la Recherche Médicale INSERM, UMR S 747, Paris, France 2 Université Paris Descartes, Sorbonne Paris Cité, UMR S 747, Paris, France
    Nat Med 19:1124-31. 2013
    ..3-phosphoinositide-dependent kinase-1 (PDK1) activity is increased in neurons infected with prions or affected by Aβ deposition and in the brains of ..
  31. pmc The kinase PDK1 is essential for B-cell receptor mediated survival signaling
    Sung Gyoo Park
    Department of Microbiology and Immunology, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America
    PLoS ONE 8:e55378. 2013
    Phosphoinositide-dependent kinase 1 (PDK1) plays an important role in integrating the T cell antigen receptor (TCR) and CD28 signals to achieve efficient NF-κB activation...
  32. doi S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt
    Ruomin Di
    MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China
    Biochem J 441:199-207. 2012
    ..Cardiomyocyte-specific deletion of PDK1 (phosphoinositide-dependent kinase 1) and Akt1/3 abolished cardioprotection after MI in the presence of rapamycin ..
  33. pmc Interaction of PDK1 with phosphoinositides is essential for neuronal differentiation but dispensable for neuronal survival
    Tinatin Zurashvili
    Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona, Spain
    Mol Cell Biol 33:1027-40. 2013
    3-Phosphoinositide-dependent protein kinase 1 (PDK1) operates in cells in response to phosphoinositide 3-kinase activation and phosphatidylinositol-3,4,5-trisphosphate [PtdIns(3,4,5)P(3)] production by activating a number of AGC kinases, ..
  34. doi PDK1 regulates platelet activation and arterial thrombosis
    Xue Chen
    Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai, China
    Blood 121:3718-26. 2013
    The effects of phosphoinositide-dependent protein kinase 1 (PDK1), a master kinase in the phosphoinositide 3-kinase/Akt pathway, on platelet activation are unknown...
  35. doi Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes
    Yonghan He
    Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, 157 Baojian Road, Harbin 150081, PR China
    Biochem Biophys Res Commun 436:169-74. 2013
    ..Radicicol decreased the phosphorylation of phosphoinositide-dependent kinase 1 (PDK1)...
  36. doi The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy
    Nagalingam R Sundaresan
    Department of Surgery, Committee on Cellular and Molecular Physiology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Sci Signal 4:ra46. 2011
    ..PIP(3)), which promotes membrane localization and phosphorylation of Akt by the upstream kinase PDK1 (phosphoinositide-dependent protein kinase 1)...
  37. doi Gender-specific interplay of signaling through β-catenin and CAR in the regulation of xenobiotic-induced hepatocyte proliferation
    Albert Braeuning
    Department of Toxicology, Institute of Experimental and Clinical Pharmacology and Toxicology, University of Tubingen, 72074 Tubingen, Germany
    Toxicol Sci 123:113-22. 2011
    ..dependent on estrogen signaling and was associated with enhanced expression of FoxM1 and elevated activity of the PDK1/p90RSK pathway...
  38. pmc PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure
    Yongheng Cao
    Division of Molecular Medicine and Medical Genetics, International Center for Medical Research and Treatment, Kobe University Graduate School of Medicine, Japan
    PLoS ONE 6:e18324. 2011
    ..synergistically on the hypothalamic phosphatidylinositol-3-OH kinase/3-phosphoinositide-dependent protein kinase 1 (PDK1)...
  39. pmc PDK1 regulates vascular remodeling and promotes epithelial-mesenchymal transition in cardiac development
    Qiuting Feng
    Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Mol Cell Biol 30:3711-21. 2010
    ..VEGFR) and the Tie2 receptor, is the phosphoinositide-3 kinase (PI3K)-phosphoinositide-dependent protein kinase 1 (PDK1)-Akt/protein kinase B (PKB) cascade that plays a critical role in development and tumorigenesis...
  40. pmc Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure
    Alfonso Mora
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 385:639-48. 2005
    The liver plays an important role in insulin-regulated glucose homoeostasis. To study the function of the PDK1 (3-phosphoinositide-dependent protein kinase-1) signalling pathway in mediating insulin's actions in the liver, we employed CRE ..
  41. pmc Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development
    Nicolas Di-Poï
    Center for Integrative Genomics, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 25:1696-712. 2005
    ....
  42. pmc Translational deregulation in PDK-1-/- embryonic stem cells
    Yuichi Tominaga
    Cancer Research Institute, University of California, 2340 Sutter St N319, San Francisco, CA 94115, USA
    Mol Cell Biol 25:8465-75. 2005
    ..We show that PKB activity is a critical downstream component of PDK-1 in mediating translation of cystatin C, RANKL, and Rab11a, whereas mTOR activity is less important for effective translation of these targets...
  43. ncbi Fine tuning PDK1 activity by phosphorylation at Ser163
    Ramon A Riojas
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78229, USA
    J Biol Chem 281:21588-93. 2006
    3-Phosphoinositide-dependent protein kinase-1 (PDK1) mediates phosphorylation and activation of members of the AGC protein kinase family and plays an essential role in insulin signaling and action...
  44. ncbi Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice
    Rexhep Rexhepaj
    Department of Physiology I, University of Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    FASEB J 20:2214-22. 2006
    The phosphoinositide-dependent kinase PDK1 activates the serum- and glucocorticoid-inducible kinase isoforms SGK1, SGK2, and SGK3 and protein kinase B, which in turn are known to up-regulate a variety of sodium-coupled transporters...
  45. pmc Essential role of PDK1 in regulating endothelial cell migration
    Luca Primo
    Department of Oncological Sciences, University of Torino, 10060 Candiolo, Italy
    J Cell Biol 176:1035-47. 2007
    The serine/threonine protein kinase phosphoinositide-dependent kinase 1 (PDK1) plays a central role in cellular signaling by phosphorylating members of the AGC family of kinases, including PKB/Akt...
  46. pmc Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis
    Heather K Bone
    Department of Pharmacy and Pharmacology, Centre for Regenerative Medicine, University of Bath, Claverton Down, Bath, BA2 7AY, UK
    J Cell Sci 120:1752-62. 2007
    ..signalling demonstrate that PI3K-mediated signals, most likely via 3-phosphoinositide-dependent protein kinase 1 (PDK1), are required for proliferation of cells within developing embryoid bodies (EBs)...
  47. ncbi Reduced Ca2+ entry and suicidal death of erythrocytes in PDK1 hypomorphic mice
    Michael Foller
    Department of Physiology, University of Tuebingen, Gmelinstr 5, 72076 Tubingen, Germany
    Pflugers Arch 455:939-49. 2008
    The phosphoinositide-dependent kinase PDK1 is a key element in the phosphoinositol-3-kinase signalling pathway, which is involved in the regulation of ion channels, transporters, cell volume and cell survival...
  48. doi PDK1 regulates cell proliferation and cell cycle progression through control of cyclin D1 and p27Kip1 expression
    Kyoko Nakamura
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 283:17702-11. 2008
    b>PDK1 (3-phosphoinositide-dependent protein kinase 1) is a key mediator of signaling by phosphoinositide 3-kinase...
  49. doi Serine 396 of PDK1 is required for maximal PKB activation
    Zoe Moon
    Department of Biology, York University, Toronto, Ontario, Canada
    Cell Signal 20:2038-49. 2008
    ..PKB is phosphorylated at T308 by its activator PDK1. PDK1 is normally excluded from the nucleus via a nuclear exclusion sequence (NES), and our previous work suggested ..
  50. pmc Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells
    Kalani L Raphael
    Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Kidney Int 75:626-33. 2009
    ..These mice lived to at least 1.5 years of age without evidence of early mortality. Our findings suggest that PCs are more important than ICs for cyst formation in polycystic kidney disease...
  51. pmc PKCdelta survival signaling in cells containing an activated p21Ras protein requires PDK1
    Shuhua Xia
    Cancer Research Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cell Signal 21:502-8. 2009
    ..anti-apoptotic signals, is activated by phosphotidylinositol 3' kinase/phosphoinositide-dependent kinase 1 (PI(3)K-PDK1) to deliver the survival signal to Akt in the environment of activated p21(Ras)...
  52. pmc Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism
    Andrew N Macintyre
    College of Life Sciences, Division of Cell Biology and Immunology, University of Dundee, Scotland, UK
    Immunity 34:224-36. 2011
    ..Akt is thus dispensable for metabolism, but the strength and duration of Akt activity dictates the CTL transcriptional program and determines CTL fate...
  53. pmc A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1
    Olga C Rodriguez
    Departments of Oncology and Pathology, Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington, DC 20057, USA
    Am J Pathol 174:2051-60. 2009
    ..Activation of mTOR was not seen. Our data demonstrates that Pten functions downstream of ErbB-2 to restrict prostate epithelial transformation by blocking full activation of the PDK1 signaling cascade.
  54. pmc Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1
    Koji Oishi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 106:13064-9. 2009
    ..We now show that the PDK1-Akt pathway regulates differentiation of telencephalic neural precursor cells (NPCs)...
  55. pmc Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains
    Nader Chalhoub
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Genes Dev 23:1619-24. 2009
    ..causes unregulated activation of downstream components of phosphatidylinositol 3-kinase (PI3K) signaling, including PDK1, and disrupts normal nervous system development and homeostasis...
  56. doi Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling
    Ying Zhang
    Institute of Physiology, University of Tubingen, Gmelinstrasse 5, D 72076 Tubingen, Germany
    FEBS Lett 583:3101-6. 2009
    ..hyperpolarization is modified by phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositide-dependent kinase PDK1. Perforated patch-clamp was performed in islet cells isolated from PDK1 hypomorphic mice (pdk1(fl/fl)), expressing ..
  57. pmc Hypoxia-induced alteration of mitochondrial genes in cardiomyocytes: role of Bnip3 and Pdk1
    Bixi Jian
    Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Shock 34:169-75. 2010
    ..upregulated genes after 24 h of hypoxia included hypoxia-inducible factor 1, alpha subunit, inducible genes Bnip3, Pdk1, and Aldoc...
  58. pmc Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt
    Ingrid Remy
    Departement de Biochimie, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    Mol Cell Biol 24:1493-504. 2004
    ..enhancing the phosphorylation of both of its regulatory sites by promoting its interaction with the upstream kinase PDK1. Further, the modulation of PKB activity by Ft1 has a strong effect on the apoptosis susceptibility of T ..
  59. pmc How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance
    Stephan Wullschleger
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Dis Model Mech 4:95-103. 2011
    ..Using insulin-resistant PDK1(K465E/K465E) PH domain knock-in mice, we found that introducing the PTEN(+/-) mutation to slightly stimulate Akt ..
  60. pmc Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1
    Jiangying Liu
    Institute for Diabetes, Obesity, and Metabolism and the Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:20494-9. 2010
    ..We further identify the 3-phosphoinositide-dependent protein kinase 1 (PDK1), a well-known kinase involved in the PI3K-Akt signaling pathway, as a direct Meis3 target, which mediates its role ..
  61. pmc T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells
    Sung Gyoo Park
    Department of Microbiology and Immunology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Immunity 33:791-803. 2010
    ..Deletion of phosphoinositide-dependent protein kinase 1 (Pdk1) in T cells via Cd4-Cre induced chronic inflammation of the intestine despite the importance of PDK1 in T cell ..
  62. pmc Cardiomyocyte-specific prolyl-4-hydroxylase domain 2 knock out protects from acute myocardial ischemic injury
    Marion Hölscher
    Department of Cardiovascular Physiology, Universitatsmedizin Gottingen, Georg August University Gottingen, Gottingen, Germany
    J Biol Chem 286:11185-94. 2011
    ..This correlated with a decreased number of apoptotic cells in the infarcted myocardium in the cPhd2(-/-) mice and significantly improved cardiac function 3 weeks after myocardial infarction...