Genomes and Genes
Gene Symbol: Pdgfrb
Description: platelet derived growth factor receptor, beta polypeptide
Alias: AI528809, CD140b, PDGFR-1, Pdgfr, CD140 antigen-like family member B, PDGF beta chain, PDGF-R-beta, PDGFR-beta, beta platelet-derived growth factor receptor, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor beta, platelet-derived growth factor receptor beta variant 1
- Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruliP Lindahl
Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
Development 125:3313-22. 1998....
- Pericyte loss and microaneurysm formation in PDGF-B-deficient miceP Lindahl
Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
Science 277:242-5. 1997..Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts...
- Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesisM Hellstrom
Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
J Cell Biol 153:543-53. 2001..Here, we addressed these issues using PDGF-B-- and PDGF receptor-beta (PDGFR-beta)--deficient mice as in vivo models of brain angiogenesis in the absence of PCs...
- The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculatureYoshitsugu Takabatake
Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine B6, Suita, Japan
J Am Soc Nephrol 20:1714-23. 2009..We conclude that CXCL12 secreted from stromal cells or podocytes acts on endothelial cells to regulate vascular development in the kidney. These findings suggest new potential therapeutic targets for remodeling the injured kidney...
- Platelet-derived growth factor receptor signalsL Claesson-Welsh
Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
J Biol Chem 269:32023-6. 1994
- Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signalingR Heuchel
Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S 75124 Uppsala, Sweden
Proc Natl Acad Sci U S A 96:11410-5. 1999..Taken together, these observations suggest a function for PDGF signaling through PI3K in interstitial fluid homeostasis by modulating the tension between cells and extracellular matrix structures...
- Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouseM Hellstrom
Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
Development 126:3047-55. 1999..we used desmin and alpha-smooth muscle actin (ASMA) as markers to analyze vSMC/PC development in PDGF-B-/- and PDGFR-beta-/- embryos. Both mutants showed a site-specific reduction of desmin-positive pericytes and ASMA-positive vSMC...
- Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant miceP Soriano
Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Genes Dev 8:1888-96. 1994..These results indicate that whereas the beta receptor is essential in certain cell types during embryonic development, its broader role may be masked because of compensation by the alpha-subunit...
- A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activityFederica Chiara
Ludwig Institute for Cancer Research, Box 595, Uppsala S 751 24, Sweden
J Biol Chem 279:42516-27. 2004..Our findings support a model whereby an activating point mutation results in a deregulated PDGFRbeta with oncogenic predisposition...
- An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during developmentRichard A Klinghoffer
Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Dev Cell 2:103-13. 2002..Our results indicate that PI3K has a predominant role in PDGFalphaR signaling in vivo and that RTK-activated signaling pathways execute both specific and overlapping functions during mammalian development...
- Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involvedLianshun Zheng
Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
J Neurosci Res 88:1273-84. 2010..The specific function of the PDGF beta-receptor (PDGFR-beta) was examined by the selective deletion of the corresponding gene using the Cre-loxP system in vitro...
- Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal miceYoko Ishii
Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
Mol Cell Neurosci 37:507-18. 2008..the ventricular and the subventricular zones (SVZ) of newborn mice to stain positive for the PDGF beta-receptor (PDGFRB)...
- PDGFB regulates the development of the labyrinthine layer of the mouse fetal placentaR Ohlsson
Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, Uppsala, S 752 36, Sweden
Dev Biol 212:124-36. 1999..We point out that the roles of PDGFB/Rbeta signaling in the placenta may be analogous to those in the developing kidney, by controlling pericytes in the labyrinthine layer and mesangial cells in the kidney...
- Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathwaysM D Tallquist
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genes Dev 14:3179-90. 2000Signal transduction by the platelet-derived growth-factor receptor beta (PDGFR-beta) tyrosine kinase is required for proper formation of vascular smooth muscle cells (VSMC)...
- Regulation of chemotaxis by the platelet-derived growth factor receptor-betaV Kundra
Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
Nature 367:474-6. 1994..Upon stimulation, the tyrosine kinase PDGF receptor-beta (PDGFR-beta) autophosphorylates and forms a complex that includes SII2(Src homology 2)-domain-containing proteins such as ..
- Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiationCharlotte Rolny
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv 20, 751 85 Uppsala, Sweden
Blood 108:1877-86. 2006..Here we present data indicating that early hematopoietic/endothelial (hemangio) precursors express PDGFR-beta based on coexpression with CD31, vascular endothelial growth factor receptor-2, and CD41 in 2 models: mouse ..
- The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functionsR A Klinghoffer
Program in Developmental Biology and Division, Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Mol Cell 7:343-54. 2001..we have created two complementary lines of knockin mice in which the intracellular signaling domains of one PDGFR have been removed and replaced by those of the other PDGFR...
- Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healingVineeth S Rajkumar
Centre for Rheumatology and Connective Tissue Disease, Department of Medicine, University College London NW3 2PF, UK, and the Clinical Research Center, University Hospital, Orebro, Sweden
Am J Pathol 169:2254-65. 2006..platelet-derived growth factor receptor-beta blockade in vivo using the platelet-derived growth factor receptor (PDGFR)-beta inhibitor imatinib mesylate on tissue repair...
- Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidneyR A Seifert
Department of Pathology, University of Washington, Seattle 98195, USA
Kidney Int 54:731-46. 1998..To understand potential PDGF signaling pathways in the kidney, we determined the expression pattern of PDGF ligand and receptor genes in mouse kidney during development and in the mature adult kidney...
- Foxc1 is required by pericytes during fetal brain angiogenesisJulie A Siegenthaler
Department of Neurology, Programs in Neuroscience and Developmental Biology, Institute for Regenerative Medicine, UC San Francisco, San Francisco, CA 94158, USA Present address Department of Pediatrics, Denver Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
Biol Open 2:647-59. 2013..Collectively these data point towards an important role for Foxc1 in certain brain pericyte functions (e.g. vessel morphogenesis) but not others (e.g. barriergenesis). ..
- Platelet-derived growth factor receptor kinase inhibitor AG-1295 promotes osteoblast differentiation in MC3T3-E1 cells via the Erk pathwayY Y Zhang
Shandong Academy of Medical Sciences, Shandong Medical Biotechnological Center, Key Laboratory for Rare Disease Research of Shandong Province, Ji Nan, Shandong, China
Biosci Trends 6:130-5. 2012Previous studies have conflicting views on the effect of platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling on osteogenesis...
- A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathyShalini Jadeja
MRC Human Genetics Unit, MRC Institute of Genetics and and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, United Kingdom
Invest Ophthalmol Vis Sci 54:3569-78. 2013..We aimed to identify the causal mutation in redeye, and evaluate it as a model for diabetic retinopathy (DR)...
- Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structureXueping Fan
Renal Section, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Cell Rep 2:52-61. 2012..These results suggest that Robo2 signaling acts as a negative regulator on nephrin to influence podocyte foot process architecture...
- Death receptors DR6 and TROY regulate brain vascular developmentStephen J Tam
Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
Dev Cell 22:403-17. 2012..These findings define a role for death receptors DR6 and TROY in CNS-specific vascular development...
- The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescenceJorge Ivan Alvarez
Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
Science 334:1727-31. 2011..Overall, the Hh pathway provides a barrier-promoting effect and an endogenous anti-inflammatory balance to CNS-directed immune attacks, as occurs in multiple sclerosis...
- PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cellsYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Nat Med 18:100-10. 2012..EPO) mRNA and protein expression by targeting stromal and perivascular cells that express PDGF receptor-β (PDGFR-β)...
- Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 proteinYuri Fukumoto
Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
J Biol Chem 286:43537-48. 2011..These results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac...
- PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemiaJie Shen
Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
J Cereb Blood Flow Metab 32:353-67. 2012..We investigated the role of PDGFR-β in tissue responses and functional recovery after photothrombolic middle cerebral artery occlusion (MCAO)...
- p19Arf represses platelet-derived growth factor receptor β by transcriptional and posttranscriptional mechanismsRyan C Widau
Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, Illinois, USA
Mol Cell Biol 32:4270-82. 2012..p19(Arf) plays an essential role in blocking signals stemming from platelet-derived growth factor receptor β (Pdgfrβ) during eye development, but the underlying mechanisms have not been clear...
- Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout micePhuong Thi Hong Nguyen
System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
PLoS ONE 6:e18004. 2011Platelet-derived growth factor (PDGF) is a potent mitogen. Extensive in vivo studies of PDGF and its receptor (PDGFR) genes have reported that PDGF plays an important role in embryogenesis and development of the central nervous system (..
- Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injuryYoko Ishii
Department of Pathology, Faculty of Medicine, University of Toyama, Toyama, Japan
J Neurochem 98:588-600. 2006..Here, we developed novel mutant mice in which the gene encoding the beta subunit of PDGFR (PDGFR-beta) was genetically deleted in CNS neurons to elucidate the role of PDGFR-beta, particularly in the post-..
- Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineagesBent Brachvogel
Department of Cell and Matrix Biology, MCRI, 3052 Parkville Victoria, Australia
Development 132:2657-68. 2005..Hence, Anxa5 expression in perivascular cells from mouse defines a novel population of cells with a distinct developmental potential...
- Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulationAlagarsamy Lakku Reddi
Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
J Biol Chem 282:29336-47. 2007..Cbl as an E3 ubiquitin ligase for ubiquitinylation and degradation of platelet-derived growth factor receptor (PDGFR) alpha and PDGFRbeta...
- Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assemblyShane S Foo
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
Cell 124:161-73. 2006..Our results indicate that the role of ephrin-B2 and EphB receptors in these processes involves Crk-p130(CAS) signaling and suggest that ephrin-B2 has some cell-cell-contact-independent functions...
- Regulation of PDGF signalling and vascular remodelling by peroxiredoxin IIMin Hee Choi
Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
Nature 435:347-53. 2005..Prx II deficiency results in increased production of H2O2, enhanced activation of PDGF receptor (PDGFR) and phospholipase Cgamma1, and subsequently increased cell proliferation and migration in response to PDGF...
- Mesenchymal cells are required for functional development of thymic epithelial cellsManami Itoi
Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
Int Immunol 19:953-64. 2007..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
- Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cellsBrent Wagner
Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
J Am Soc Nephrol 18:2903-11. 2007Mice deficient in either platelet-derived growth factor (PDGF) B chain or PDGF receptor (PDGFR) beta lack mesangial cells...
- Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanomaShioto Suzuki
Ludwig Institute for Cancer Research, Uppsala Branch, Uppsala, Sweden
BMC Cancer 7:224. 2007Platelet-derived growth factor (PDGF)-BB and PDGF receptor (PDGFR)-beta are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-beta is expressed by mural cells, including pericytes...
- Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor proteinVivian Y H Hook
Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 283:7745-53. 2008....
- Angiopoietin-1 is essential in mouse vasculature during development and in response to injuryMarie Jeansson
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
J Clin Invest 121:2278-89. 2011..These findings redefine our understanding of the biological roles of angiopoietin-1: it is dispensable in quiescent vessels but has a powerful ability to modulate the vascular response after injury...
- The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stressTae Sun Kim
Department of Molecular Neurobiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, 467 8601, Japan
Dis Model Mech 3:752-62. 2010..which in turn promotes survival of neurons by inducing expression of platelet-derived growth factor receptor β (PDGFRB)...
- Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathwaysKaren Mendelson
Arthritis and Tissue Degeneration Program, The Hospital for Special Surgery, New York, New York 10021, USA
J Biol Chem 285:25024-32. 2010..This study identifies the principal sheddase for the PDGFRbeta and provides new insights into the mechanism of PDGFRbeta-dependent signal transduction and cross-talk with the EGFR...
- Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stressVishnu Chintalgattu
Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
J Clin Invest 120:472-84. 2010..In mice in which Pdgfrb was knocked out in the heart in development or in adulthood, exposure to load-induced stress resulted in cardiac ..
- Strong oligomerization behavior of PDGFbeta receptor transmembrane domain and its regulation by the juxtamembrane regionsJoanne Oates
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
Biochim Biophys Acta 1798:605-15. 2010....
- Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cellsMasahiro Koide
Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto 602 8566, Japan
Proc Natl Acad Sci U S A 108:9472-7. 2011..These functions of ARIA might offer a unique therapeutic potential...
- Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuliRui Benedito
Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisboa, Portugal
BMC Dev Biol 8:117. 2008..Dll4 null embryos die very early in development with severely reduced arterial calibre and lumen and loss of arterial cell identity...
- Platelet-derived growth factor receptor beta-subtype regulates proliferation and migration of gonocytesSabrina Basciani
Department of Medical Physiopathology, Sapienza University, Policlinico Umberto I, 00161 Rome, Italy
Endocrinology 149:6226-35. 2008..0 (E18) and up to P5, the gonocytes express platelet-derived growth factor (PDGF) receptor beta-subtype (PDGFR-beta) and that during the same time period, the Sertoli cells express PDGF-B and PDGF-D, both ligands for PDGFR-..
- Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gutM Kurahashi
Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya, Japan
Neurogastroenterol Motil 20:521-31. 2008..The selective PDGF receptor inhibitor AG1295 suppressed the differentiation of LMC in gut explants. We conclude that PDGF signals play critical roles in the differentiation of LMC in mouse embryonic gut...
- A myocardial lineage derives from Tbx18 epicardial cellsChen Leng Cai
Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
Nature 454:104-8. 2008..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
- A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and humanA M Buchberg
Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
Genetics 122:153-61. 1989..and the known linkage homologies that exist between murine chromosome 11 and human chromosomes (Mpo, Ngfr, Pdgfr and Fms). Two of the latter genes, Mpo and Ngfr, mapped to mouse chromosome 11...
- The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand bindingM A Broome
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
Oncogene 14:17-34. 1997..However, Tyr 138 phosphorylation was found to diminish SH3 domain peptide ligand binding ability in vitro...
- p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-YAnders Hackzell
Department of Cell Biology, Institute of Anatomy and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
J Biol Chem 277:39769-76. 2002..Our results indicate that serum stimulation induces c-Myc and p73alpha, leading to the down-regulation of PDGF beta-receptor expression by repressing its transcription...
- Sp1 is a key regulator of the PDGF beta-receptor transcriptionC Molander
Institute of Anatomy and Cell Biology, Goteborg University, Gothenburg, Sweden
Mol Biol Rep 28:223-33. 2001..However, we could not find any effect of Sp1 in the c-Myc-mediated repression on the PFDGF beta-receptor promoter, since the deletion of SpI binding sites could not attenuate the repression by c-Myc on the promoter activity...
- PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptorE Bergsten
Ludwig Institute for Cancer Research, Stockholm Branch, PO Box 240, S 171 77 Stockholm, Sweden
Nat Cell Biol 3:512-6. 2001..The PDGF alpha-receptor (PDGFR-alpha) binds to all three PDGF chains, whereas the beta-receptor (PDGFR-beta) binds only to PDGF-B...
- PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesisH Riedel
Department of Biological Sciences, Wayne State University, Detroit, Michigan, MI 48202, USA
Oncogene 19:39-50. 2000..We have mapped Y740 as a site of PDGFR beta that is involved in the association with PSM...
- The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic miceK A Ritchie
Medical Research Service, VA Puget Sound Health Care System, Seattle, WA 98108, USA
Leukemia 13:1790-803. 1999..This murine model of CMML parallels a myeloproliferative syndrome in humans and implicates the Tel-PDGFRbeta fusion protein in its pathogenesis...
- A multipoint genetic linkage map of mouse chromosome 18K R Johnson
Jackson Laboratory, Bar Harbor, Maine 04609
Genomics 13:1143-9. 1992..3-Tpi-10-11.8-(Egr-1, Hmg17-rs9)-2.1-Fgfa-2.2-Grl-1-10.1-(Cdx-1, Csfmr, Pdgfrb, Pdea, Rps14)-2.1-Adrb-2-22.9-Mbp...
- Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domainS Miyake
Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 274:16619-28. 1999..compromised the PDGF-inducible tyrosine phosphorylation of Cbl although this mutant could still associate with the PDGFR. More importantly, the G306E mutation abrogated the ability of Cbl to enhance the ligand-induced ubiquitination ..
- Nuclear factor Y controls the basal transcription activity of the mouse platelet-derived-growth-factor beta-receptor geneA Ishisaki
Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
Eur J Biochem 246:142-6. 1997..The binding proteins were affinity purified and identified as the NF-Y transcription factor by western blotting. Our results indicate that NF-Y controls the basal transcription activity of the mouse PDGF beta-receptor gene...
- Developmental distribution of platelet-derived growth factor in the mouse central nervous systemJ B Hutchins
Department of Anatomy, University of Mississippi Medical Center, Jackson 39216 4505
Brain Res Dev Brain Res 67:121-35. 1992..By E15, both PDGF isoform and PDGF receptor beta subunit immunoreactivity have declined to near-background levels in the sensory ganglia, while in the spinal cord and developing forebrain, levels of all PDGF-related proteins remain high...
- Isolation and characterization of the platelet-derived growth factor beta receptor promoterE Shinbrot
Daiichi Research Center, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
Dev Dyn 208:211-9. 1997..The further analysis of this promoter will help elucidate the transcriptional regulation of expression of the PDGFbeta r, and provide a useful tool for directing expression of heterologous genes...
- SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinasesG S Feng
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Science 259:1607-11. 1993..The Syp gene is widely expressed throughout embryonic mouse development and in adult tissues. Thus, Syp may function in mammalian embryonic development and as a common target of both receptor and nonreceptor tyrosine kinases...
- Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomesS Shafqat
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Pharmacol 48:219-29. 1995..These findings warrant the consideration of a synaptic regulatory role for this transporter and its presumed natural substrate, L-proline, in the mammalian central nervous system...
- Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestationM C Bidwell
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Endocrinology 136:5189-201. 1995....
- Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrinsJoseph H McCarty
Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Mol Cell Biol 22:7667-77. 2002..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
- Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell developmentMichelle D Tallquist
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
PLoS Biol 1:E52. 2003..The combined in vivo and biochemical data suggest that the summation of pathways associated with the PDGFRbeta signal transduction determines the expansion of developing v/p cells...
- Forced expression of platelet-derived growth factor B in the mouse cerebellar primordium changes cell migration during midline fusion and causes cerebellar ectopiaJohanna Andrae
Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
Mol Cell Neurosci 26:308-21. 2004..b>PDGFR-alpha- and laminin alpha1-positive meningeal cells migrated inwards, attracted by the ectopic transgene expression ..
- S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)Linnea M Baudhuin
Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
FASEB J 18:341-3. 2004..In addition, S1P-stimulated activation of Akt, but not ERK, was blocked by a PDGF receptor (PDGFR)-specific inhibitor, AG1296, suggesting a S1P3-mediated specific crosstalk between the Akt signaling pathways of ..
- Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cellsChristine Rampon
Laboratoire Développement et Vieillissement de l Endothélium CEA Inserm EMI 0219, Grenoble, France
Exp Cell Res 302:48-60. 2005..We conclude that PCDH12 has a unique expression pattern and that its deficiency does not lead to conspicuous abnormalities. Moreover, PCDH12 is the first specific marker for both glycogen-rich trophoblasts and mesangial cells...
- The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular systemXiaowei Lu
Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Nature 432:179-86. 2004..Netrin-1 causes endothelial filopodial retraction, but only when UNC5B is present. Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system...
- Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphataseCamilla Persson
Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, S 751 24 Uppsala, Sweden
Mol Cell Biol 24:2190-201. 2004..In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors...
- Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasisTatiana V Petrova
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
Nat Med 10:974-81. 2004..Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD...
- Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptorRina Plattner
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell Biol 24:2573-83. 2004..signals such as the platelet-derived growth factor (PDGF) and functions downstream of the PDGF-beta receptor (PDGFR) to mediate biological processes such as membrane ruffling, mitogenesis, and chemotaxis...
- Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesisChristian Rupp
Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
Cancer Immun 6:10. 2006..In future studies, the search for intrinsic or extrinsic signals contributing to endosialin induction in cancer stroma will be of interest...
- The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factorJaclyn S Long
Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
Prostaglandins Other Lipid Mediat 80:74-80. 2006..These findings resolve an important issue regarding the functional role of the S1P(1) receptor in regulating MEF migration and suggest an important role within the context of PDGFbeta receptor-S1P(1) receptor complex signaling...
- Roles of platelet-derived growth factor in the developing and mature nervous systemsC F Valenzuela
Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
Brain Res Brain Res Rev 24:77-89. 1997..We also discuss the modulatory effects of PDGF on synaptic transmission, its role in neoplastic and non-neoplastic conditions of the central nervous system, and the neuroprotective effects of this growth factor...
- Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitroPeetra U Magnusson
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Arterioscler Thromb Vasc Biol 27:2142-9. 2007..This study describes the consequences of a constitutively activating mutation of the PDGFR-beta (Pdgfrb(D849V)) introduced into embryonic stem cells with respect to vasculogenesis/angiogenesis in vitro and in vivo.
- The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteinsM Dean Chamberlain
Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan S7N 4H4, Canada
J Biol Chem 279:48607-14. 2004..or degradation of activated receptor tyrosine kinases such as the platelet-derived growth factor receptor (PDGFR)...
- Contractile activity of skeletal musculature involved in breathing is essential for normal lung cell differentiation, as revealed in Myf5-/-:MyoD-/- embryosMohammad Reza Inanlou
Dalhousie University, Faculty of Medicine, Department of Anatomy and Neurobiology, Halifax, Nova Scotia, Canada
Dev Dyn 233:772-82. 2005..Together, our findings suggest that pulmonary distension due to fetal breathing-like movements plays an important role not only in lung growth but also in lung cell differentiation...
- Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factorYuji Saito
Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
J Biol Chem 277:23216-22. 2002..Because PDGF-mediated ERK activation is enhanced in Chinese hamster ovary cells that overexpress Gab1, Gab1 serves as an important link between PKC and ERK activation by PDGFbeta receptors in VSMC...
- Photoreceptor-specific overexpression of platelet-derived growth factor induces proliferation of endothelial cells, pericytes, and glial cells and aberrant vascular development: an ultrastructural and immunocytochemical studyStanley A Vinores
Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9289, USA
Brain Res Dev Brain Res 140:169-83. 2003..Pericytes and glial cells are usually found in clusters and are not associated with the abnormal vessels. The lack of this association may account for the failure to form a mature vasculature...
- Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injurySekiko Taneda
Department of Pathology, University of Washington, Seattle, Washington, USA
J Am Soc Nephrol 14:2544-55. 2003..These observations suggest that PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF-Rbeta in both human obstructive nephropathy and the corresponding murine model of UUO...
- Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promotersGiuseppina Caretti
Dipartimento di Biologia Animale, Università di Modena e Reggio, Via Campi 213 D, 41100 Modena, Italy
J Biol Chem 278:30435-40. 2003..These data indicate that following the release of E2Fs/HDACs, a hierarchy of PCAF-NF-Y-p300 interactions and H3-H4 acetylations are required for activation of cell-cycle promoters...
- Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphologyShinsuke Nakata
Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka, Japan
J Biol Chem 282:37815-25. 2007..Thus, afadin plays a critical role in the proper regulation of the PDGF-induced activation of PDGF receptor and signaling by Ras-ERK. This effect, which is mediated by SHP-2, impacts cellular morphology...
- Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGFbeta receptorJennifer B Ptacek
Department of Genetics and Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 104:11945-50. 2007..Our results also suggested that excluding hydrophilic residues from small TM proteins and peptides is a strategy to increase the specificity of heteromeric TM helix-helix interactions...
- Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null miceKoichi Kozaki
Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
Am J Pathol 161:1395-407. 2002..Thus, elimination of PDGF-B from circulating cells or blockade of PDGF receptors does not appear sufficient to prevent smooth muscle accumulation in advanced lesions of atherosclerosis...
- Involvement of platelet-derived growth factor receptor-beta in maintenance of mesenchyme and sensory epithelium of the neonatal mouse inner earHisamitsu Hayashi
Department of Otolaryngology, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu shi, Gifu 501 1194, Japan
Hear Res 245:73-81. 2008Platelet-derived growth factor receptor (PDGFR) signaling has been demonstrated to play a pivotal role in early embryonic development...
- Platelet-derived growth factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta in murine nucleus tractus solitariusYoshiaki Ohi
Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
Brain Res 1159:77-85. 2007Although platelet-derived growth factor (PDGF)-BB activates PDGF receptor-beta (PDGFR-beta) and, in turn, inhibits the glutamate N-methyl-D-aspartate (NMDA) receptor function, whether PDGF-BB modulates the CNS function mediated by ..
- A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 allelesKristen Pollizzi
Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Mol Genet 18:2378-87. 2009..Tsc2-del3 mice also serve as a model for hypomorphic TSC2 missense mutations reported in TSC patients...
- Cooperation between the PDGF receptors in cardiac neural crest cell migrationAlicia M Richarte
Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Dev Biol 306:785-96. 2007..Previously, we had shown that disruption of the platelet-derived growth factor receptor (PDGFR) alpha in NCCs resulted in defects in craniofacial and aortic arch development, the latter with variable ..
- Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cellsBin Zheng
Department of Biochemistry and Molecular Biology, Hebei Medical University, Zhongshan East Road, Shijiazhuang 050017, China
J Biol Chem 284:22773-85. 2009..investigated the mechanisms whereby Klf4 mediates the growth inhibitory effects in VSMCs through RAR alpha and PDGFR beta. We demonstrated that Klf4 directly binds to the 5' regulatory region of RAR alpha, down-regulates RAR alpha ..
- Chimera analysis supports a predominant role of PDGFRbeta in promoting smooth-muscle cell chemotaxis after arterial injuryBernard S Buetow
Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
Am J Pathol 163:979-84. 2003..We conclude that the most significant direct role of PDGFRbeta is to mediate responses that involve cell migration rather than proliferation...
- Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolutionR J Oakey
Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
Genomics 10:338-44. 1991..We have identified a region that may have been translocated during evolution and suggest that the human genomic organization of adrenergic receptors more closely resembles that of a putative primordial ancestor...
- The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesisKoichi Hamada
Department of Molecular Biology, Department of Microbiology, Department of Gastroenterology, Akita University School of Medicine, Akita 010 8543, Japan
Genes Dev 19:2054-65. 2005..Pten is thus indispensable for normal cardiovascular morphogenesis and post-natal angiogenesis, including tumor angiogenesis...
- Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic miceAnnica Pontén
Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
Circ Res 97:1036-45. 2005..PDGF)-D is a member of the PDGF/vascular endothelial growth factor family that activates PDGF receptor beta (PDGFR-beta)...
- Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiationYan Wang
Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D C 20057, USA
Endocrinology 148:2233-50. 2007We have shown previously that neonatal testicular gonocytes express platelet-derived growth factor receptors (PDGFR) alpha and beta...
- Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signalingC S Rani
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, D C 20007, USA
J Biol Chem 272:10777-83. 1997..Thus, regulation of sphingosine kinase activity defines divergence in signal transduction pathways of PDGF and EGF receptors leading to mitogen-activated protein kinase activation...
- MEDIATORS OF BLOOD-RETINAL BARRIER BREAKDOWNSTANLEY VINORES; Fiscal Year: 2002....
- Proteomics/Genomics of Opiate Analgesia and AddictionVivian Hook; Fiscal Year: 2004..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
- INTEGRATED DNA SEQUENCING SYSTEMVivian Hook; Fiscal Year: 2002..abstract_text> ..
- Serpin Protease Inhibitors & Opioid NeuropeptidesVivian Hook; Fiscal Year: 2006..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
- Is non-canonical Wnt signaling required in cardiac neural crest cells?Ethan David Cohen; Fiscal Year: 2008..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..
- POMC Processing and Beta-Endorphine-Related Opioid PeptidesVivian Y H Hook; Fiscal Year: 2010..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
- BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDESVivian Hook; Fiscal Year: 2009..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..