Pdgfrb

Summary

Gene Symbol: Pdgfrb
Description: platelet derived growth factor receptor, beta polypeptide
Alias: AI528809, CD140b, PDGFR-1, Pdgfr, platelet-derived growth factor receptor beta, CD140 antigen-like family member B, PDGF beta chain, PDGF-R-beta, PDGFR-beta, beta platelet-derived growth factor receptor, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor beta variant 1
Species: mouse

Top Publications

  1. ncbi Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
    P Lindahl
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 125:3313-22. 1998
  2. ncbi Platelet-derived growth factor receptor signals
    L Claesson-Welsh
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    J Biol Chem 269:32023-6. 1994
  3. ncbi Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
    P Soriano
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genes Dev 8:1888-96. 1994
  4. ncbi Regulation of chemotaxis by the platelet-derived growth factor receptor-beta
    V Kundra
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Nature 367:474-6. 1994
  5. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
  6. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
  7. ncbi PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta
    R Ohlsson
    Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, Uppsala, S 752 36, Sweden
    Dev Biol 212:124-36. 1999
  8. pmc Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling
    R Heuchel
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S 75124 Uppsala, Sweden
    Proc Natl Acad Sci U S A 96:11410-5. 1999
  9. pmc Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways
    M D Tallquist
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 14:3179-90. 2000
  10. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001

Research Grants

Scientific Experts

Detail Information

Publications132 found, 100 shown here

  1. ncbi Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
    P Lindahl
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 125:3313-22. 1998
    ....
  2. ncbi Platelet-derived growth factor receptor signals
    L Claesson-Welsh
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    J Biol Chem 269:32023-6. 1994
  3. ncbi Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
    P Soriano
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genes Dev 8:1888-96. 1994
    ..These results indicate that whereas the beta receptor is essential in certain cell types during embryonic development, its broader role may be masked because of compensation by the alpha-subunit...
  4. ncbi Regulation of chemotaxis by the platelet-derived growth factor receptor-beta
    V Kundra
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Nature 367:474-6. 1994
    ..Upon stimulation, the tyrosine kinase PDGF receptor-beta (PDGFR-beta) autophosphorylates and forms a complex that includes SII2(Src homology 2)-domain-containing proteins such as ..
  5. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
    ..Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts...
  6. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
    ..we used desmin and alpha-smooth muscle actin (ASMA) as markers to analyze vSMC/PC development in PDGF-B-/- and PDGFR-beta-/- embryos. Both mutants showed a site-specific reduction of desmin-positive pericytes and ASMA-positive vSMC...
  7. ncbi PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta
    R Ohlsson
    Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, Uppsala, S 752 36, Sweden
    Dev Biol 212:124-36. 1999
    ..We point out that the roles of PDGFB/Rbeta signaling in the placenta may be analogous to those in the developing kidney, by controlling pericytes in the labyrinthine layer and mesangial cells in the kidney...
  8. pmc Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling
    R Heuchel
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S 75124 Uppsala, Sweden
    Proc Natl Acad Sci U S A 96:11410-5. 1999
    ..Taken together, these observations suggest a function for PDGF signaling through PI3K in interstitial fluid homeostasis by modulating the tension between cells and extracellular matrix structures...
  9. pmc Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways
    M D Tallquist
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 14:3179-90. 2000
    Signal transduction by the platelet-derived growth-factor receptor beta (PDGFR-beta) tyrosine kinase is required for proper formation of vascular smooth muscle cells (VSMC)...
  10. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
    ..Here, we addressed these issues using PDGF-B-- and PDGF receptor-beta (PDGFR-beta)--deficient mice as in vivo models of brain angiogenesis in the absence of PCs...
  11. ncbi An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development
    Richard A Klinghoffer
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 2:103-13. 2002
    ..Our results indicate that PI3K has a predominant role in PDGFalphaR signaling in vivo and that RTK-activated signaling pathways execute both specific and overlapping functions during mammalian development...
  12. pmc Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development
    Michelle D Tallquist
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 1:E52. 2003
    ..The combined in vivo and biochemical data suggest that the summation of pathways associated with the PDGFRbeta signal transduction determines the expansion of developing v/p cells...
  13. pmc Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor
    Rina Plattner
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:2573-83. 2004
    ..signals such as the platelet-derived growth factor (PDGF) and functions downstream of the PDGF-beta receptor (PDGFR) to mediate biological processes such as membrane ruffling, mitogenesis, and chemotaxis...
  14. ncbi A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity
    Federica Chiara
    Ludwig Institute for Cancer Research, Box 595, Uppsala S 751 24, Sweden
    J Biol Chem 279:42516-27. 2004
    ..Our findings support a model whereby an activating point mutation results in a deregulated PDGFRbeta with oncogenic predisposition...
  15. ncbi Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing
    Zhiyang Gao
    Department of Pathology, Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Biol Chem 280:9375-89. 2005
    This study provides new perspectives of the unique aspects of platelet-derived growth factor beta-receptor (PDGFR-beta) signaling and biological responses through the establishment of a mutant mouse strain in which two loxP sequences ..
  16. ncbi Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly
    Shane S Foo
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Cell 124:161-73. 2006
    ..Our results indicate that the role of ephrin-B2 and EphB receptors in these processes involves Crk-p130(CAS) signaling and suggest that ephrin-B2 has some cell-cell-contact-independent functions...
  17. ncbi Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury
    Yoko Ishii
    Department of Pathology, Faculty of Medicine, University of Toyama, Toyama, Japan
    J Neurochem 98:588-600. 2006
    ..Here, we developed novel mutant mice in which the gene encoding the beta subunit of PDGFR (PDGFR-beta) was genetically deleted in CNS neurons to elucidate the role of PDGFR-beta, particularly in the post-..
  18. ncbi Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes
    Cecilia Bondjers
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    FASEB J 20:1703-5. 2006
    ..The three new brain pericyte markers are signaling molecules implicated in ion transport and intercellular signaling, potentially opening new windows on pericyte function in brain microvessels...
  19. ncbi Klf2 is an essential regulator of vascular hemodynamic forces in vivo
    John S Lee
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Dev Cell 11:845-57. 2006
    ..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function...
  20. doi Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice
    Yoko Ishii
    Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
    Mol Cell Neurosci 37:507-18. 2008
    ..the ventricular and the subventricular zones (SVZ) of newborn mice to stain positive for the PDGF beta-receptor (PDGFRB)...
  21. doi Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression
    Shinya Yamamoto
    Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 283:23139-49. 2008
    ..Thus, PDGF signaling is a possible mechanism involved in the interaction between epithelial and neural crest-derived mesenchyme...
  22. pmc The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine B6, Suita, Japan
    J Am Soc Nephrol 20:1714-23. 2009
    ..We conclude that CXCL12 secreted from stromal cells or podocytes acts on endothelial cells to regulate vascular development in the kidney. These findings suggest new potential therapeutic targets for remodeling the injured kidney...
  23. doi Foxn1 is essential for vascularization of the murine thymus anlage
    Kazuya Mori
    Department of Immunology and Microbiology, Meiji University of Integrative Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Cell Immunol 260:66-9. 2010
    ..The present results indicate that Foxn1 dependent epithelial development is essential for vascularization of the thymus anlagen...
  24. doi Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved
    Lianshun Zheng
    Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
    J Neurosci Res 88:1273-84. 2010
    ..The specific function of the PDGF beta-receptor (PDGFR-beta) was examined by the selective deletion of the corresponding gene using the Cre-loxP system in vitro...
  25. pmc Pericytes are required for blood-brain barrier integrity during embryogenesis
    Richard Daneman
    UCSF Department of Anatomy, 513 Parnassus Avenue, HSW1301, San Francisco, California 94143 0452, USA
    Nature 468:562-6. 2010
    ..Analysing mice with null and hypomorphic alleles of Pdgfrb, which have defects in pericyte generation, we demonstrate that pericytes are necessary for the formation of the ..
  26. pmc Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging
    Robert D Bell
    Department of Neurosurgery and Neurology, University of Rochester Medical Center, Center for Neurodegenerative and Vascular Brain Disorders, Rochester, NY 14642, USA
    Neuron 68:409-27. 2010
    ..Thus, pericytes control key neurovascular functions that are necessary for proper neuronal structure and function, and pericyte loss results in a progressive age-dependent vascular-mediated neurodegeneration...
  27. pmc Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice
    Phuong Thi Hong Nguyen
    System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    PLoS ONE 6:e18004. 2011
    Platelet-derived growth factor (PDGF) is a potent mitogen. Extensive in vivo studies of PDGF and its receptor (PDGFR) genes have reported that PDGF plays an important role in embryogenesis and development of the central nervous system (..
  28. pmc Perlecan maintains microvessel integrity in vivo and modulates their formation in vitro
    Erika Gustafsson
    Department of Experimental Pathology, Lund University, Lund, Sweden
    PLoS ONE 8:e53715. 2013
    ..Altogether these findings suggest that perlecan supports the maintenance of brain and skin subendothelial BMs and promotes vasculo- and angiogenesis by modulating FGF-2 function...
  29. pmc FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney
    Jennifer L Fetting
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Development 141:17-27. 2014
    ....
  30. pmc Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development
    Scott C Boyle
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 141:346-54. 2014
    ..Interestingly, Pdgfrb-positive VSMCs do not enter the vascular cleft and cannot rescue the mesangial deficiency...
  31. ncbi The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions
    R A Klinghoffer
    Program in Developmental Biology and Division, Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 7:343-54. 2001
    ..we have created two complementary lines of knockin mice in which the intracellular signaling domains of one PDGFR have been removed and replaced by those of the other PDGFR...
  32. ncbi Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation
    Charlotte Rolny
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv 20, 751 85 Uppsala, Sweden
    Blood 108:1877-86. 2006
    ..Here we present data indicating that early hematopoietic/endothelial (hemangio) precursors express PDGFR-beta based on coexpression with CD31, vascular endothelial growth factor receptor-2, and CD41 in 2 models: mouse ..
  33. pmc Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing
    Vineeth S Rajkumar
    Centre for Rheumatology and Connective Tissue Disease, Department of Medicine, University College London NW3 2PF, UK, and the Clinical Research Center, University Hospital, Orebro, Sweden
    Am J Pathol 169:2254-65. 2006
    ..platelet-derived growth factor receptor-beta blockade in vivo using the platelet-derived growth factor receptor (PDGFR)-beta inhibitor imatinib mesylate on tissue repair...
  34. ncbi Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidney
    R A Seifert
    Department of Pathology, University of Washington, Seattle 98195, USA
    Kidney Int 54:731-46. 1998
    ..To understand potential PDGF signaling pathways in the kidney, we determined the expression pattern of PDGF ligand and receptor genes in mouse kidney during development and in the mature adult kidney...
  35. ncbi Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors
    G Alonso
    Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    J Biol Chem 270:9840-8. 1995
    ..These observations support a model in which the enzymatic activity of Src family tyrosine kinases is controlled by intra- and intermolecular interactions of tyrosine-phosphorylated peptides with the SH2 domain of the kinases...
  36. pmc Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice
    M Kozlowski
    Department of Medicine, University of Toronto, Ontario, Canada
    J Exp Med 178:2157-63. 1993
    ..These observations provide strong evidence that the motheaten phenotypic results from loss-of-function mutations in the PTP1C gene and imply a critical role for PTP1C in the regulation of hemopoietic differentiation and immune function...
  37. ncbi Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation
    B McCright
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Development 128:491-502. 2001
    ..These data identify novel developmental roles for Notch2 in kidney, heart and eye development...
  38. pmc Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells
    Cecilia Bondjers
    Department of Medical Biochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Am J Pathol 162:721-9. 2003
    ..Absence of RGS5 expression in PDGF-B and PDGFR beta-null embryos correlated with pericyte loss in these mice...
  39. pmc Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice
    Jolanta E Pitera
    Institute of Child Health, University College London, London, UK
    Am J Pathol 165:1895-906. 2004
    ..In wild-type neonates, alpha smooth muscle actin (alpha SMA), platelet-derived growth factor receptor beta (PDGFR beta), and desmin-expressing cells were not prominent in this compartment...
  40. ncbi PI3K is involved in PDGF-beta receptor upregulation post-PDGF-BB treatment in mouse HSC
    Carmen G Lechuga
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Physiol Gastrointest Liver Physiol 291:G1051-61. 2006
    ..We also showed that receptor reappearance is time and dose dependent, being more delayed in cells treated with 50 ng/ml (48 h) compared with 10 ng/ml (24 h)...
  41. pmc Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis
    Frank Kuhnert
    Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:10185-90. 2008
    ..These studies using highly specific soluble receptors suggest that additivity between VEGFR and PDGFRbeta inhibition depends on the strength of VEGF blockade and appears minimal under conditions of maximal VEGF antagonism...
  42. pmc Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations
    Amy M Mellgren
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Circ Res 103:1393-401. 2008
    ..To investigate the role of platelet-derived growth factor receptor (PDGFR)beta in development of epicardial-derived vascular smooth muscle cells (VSMCs), we examined PDGFRbeta(-/-) and ..
  43. pmc Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells
    Erxi Wu
    Informatics Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e3794. 2008
    ..we used wild-type mouse embryonic fibroblasts (MEF), MEF null for either PDGFRalpha, beta, or both to dissect PDGF-PDGFR signaling pathways...
  44. pmc The PDGF signaling pathway controls multiple steroid-producing lineages
    Jennifer Schmahl
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 22:3255-67. 2008
    ..Therefore, PDGF signaling may constitute a common mechanism in the control of multiple steroidogenic lineages...
  45. pmc Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization
    C Guignabert
    Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford Univ School of Medicine, CA 94305 5162, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1082-90. 2009
    ..Thus the disruption of PPARgamma signaling in EC is sufficient to cause mild PAH and to impair recovery from CH-induced PAH. Inhibition of heightened PDGF-Rbeta signaling is sufficient to reverse PAH in this genetic model...
  46. doi Dimerization drives PDGF receptor endocytosis through a C-terminal hydrophobic motif shared by EGF receptor
    Justin Pahara
    Department of Cell Biology and Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    Exp Cell Res 316:2237-50. 2010
    Like many other receptor tyrosine kinases (RTKs), platelet-derived growth factor (PDGF) receptor beta (PDGFR-beta) is internalized and degraded in lysosomes in response to PDGF stimulation, which regulates many aspects of cell signalling...
  47. doi Platelet-derived growth factor (PDGF)-BB produces NO-mediated relaxation and PDGF receptor β-dependent tonic contraction in murine iliac lymph vessels
    Daisuke Maejima
    Department of Physiology, Shinshu University School of Medicine, Matsumoto, Japan
    Microcirculation 18:474-86. 2011
    ..PDGF receptor β-mediated tonic contraction of the muscles through increased Ca(2+) influx through the membrane and the release of membrane-bound and intracellular Ca(2+) ...
  48. pmc A novel function for platelet-derived growth factor D: induction of osteoclastic differentiation for intraosseous tumor growth
    W Huang
    Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Oncogene 31:4527-35. 2012
    Although increasing evidence suggests a critical role for platelet-derived growth factor (PDGF) receptor β (β-PDGFR) signaling in prostate cancer (PCa) progression, the precise roles of β-PDGFR and PDGF isoform-specific cell signaling ..
  49. pmc Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling
    Akanksha Chhabra
    Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 22:651-9. 2012
    ..Loss of PDGF-B or its receptor, PDGFRβ, induced definitive erythropoiesis in placental labyrinth vasculature...
  50. doi Predominant role of PDGF receptor transactivation in Wnt3a-induced osteoblastic cell proliferation
    Joseph Caverzasio
    Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 28:260-70. 2013
    ....
  51. doi Combined inhibition of c-Abl and PDGF receptors for prevention and treatment of murine sclerodermatous chronic graft-versus-host disease
    Pawel Zerr
    Department of Internal Medicine III, University of Erlangen Nuremberg, Germany
    Am J Pathol 181:1672-80. 2012
    ..the effects of the combined inhibition of the Abelson kinase (c-Abl) and platelet-derived growth factor receptors (PDGFR) in experimental sclerodermatous cGvHD...
  52. pmc Thymosin β4 is not required for embryonic viability or vascular development
    Indroneal Banerjee
    Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Circ Res 112:e25-8. 2013
    ..These data are in direct contrast to our published global and cardiac-specific Tβ4-knockout lines. Thus, the role of Tβ4 needs to be clarified to understand its importance in cardiovascular development...
  53. pmc Lymphatic function is required prenatally for lung inflation at birth
    Zoltan Jakus
    Department of Medicine, 2 Cardiovascular Institute, and 3 Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104
    J Exp Med 211:815-26. 2014
    ..They explain respiratory failure in infants with congenital pulmonary lymphangiectasia, and suggest that inadequate late gestation lymphatic function may also contribute to respiratory failure in premature infants. ..
  54. doi Cited2 is required in trophoblasts for correct placental capillary patterning
    Julie L M Moreau
    Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia Electronic address
    Dev Biol 392:62-79. 2014
    ....
  55. pmc Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation
    Christopher J Turner
    Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Biol 392:381-92. 2014
    ..Here, we report that deletion of the gene encoding the integrin-α5 subunit (Itga5) using the Pdgfrb-Cre transgenic mouse line, leads to oedema, haemorrhage and increased levels of embryonic lethality...
  56. doi Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke
    Noriko Makihara
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan
    Exp Neurol 264:127-34. 2015
    ..Here, we examined whether platelet-derived growth factor receptor β (PDGFRβ), a well-known indispensable molecule for migration, proliferation, and survival of pericytes, was involved in ..
  57. pmc Pericytes are progenitors for coronary artery smooth muscle
    Katharina S Volz
    Stem Cell and Regenerative Medicine PhD Program, Stanford School of Medicine, Stanford, United States
    elife 4:. 2015
    ..Our data are the first demonstration that pericytes are progenitors for smooth muscle, and their presence in adult hearts reveals a new potential cell type for targeting during cardiovascular disease. ..
  58. pmc Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins
    Maria H Ulvmar
    Department of Immunology Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 751 85, Uppsala, Sweden
    Genesis 54:350-8. 2016
    The Pdgfrb-Cre line has been used as a tool to specifically target pericytes and vascular smooth muscle cells...
  59. pmc PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia
    Jie Shen
    Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    J Cereb Blood Flow Metab 32:353-67. 2012
    ..We investigated the role of PDGFR-β in tissue responses and functional recovery after photothrombolic middle cerebral artery occlusion (MCAO)...
  60. pmc Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein
    Yuri Fukumoto
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    J Biol Chem 286:43537-48. 2011
    ..These results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac...
  61. doi PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
    Yuan Xue
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Nat Med 18:100-10. 2011
    ..EPO) mRNA and protein expression by targeting stromal and perivascular cells that express PDGF receptor-β (PDGFR-β)...
  62. doi The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
    Jorge Ivan Alvarez
    Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Science 334:1727-31. 2011
    ..Overall, the Hh pathway provides a barrier-promoting effect and an endogenous anti-inflammatory balance to CNS-directed immune attacks, as occurs in multiple sclerosis...
  63. doi Death receptors DR6 and TROY regulate brain vascular development
    Stephen J Tam
    Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Dev Cell 22:403-17. 2012
    ..These findings define a role for death receptors DR6 and TROY in CNS-specific vascular development...
  64. pmc Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure
    Xueping Fan
    Renal Section, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Cell Rep 2:52-61. 2012
    ..These results suggest that Robo2 signaling acts as a negative regulator on nephrin to influence podocyte foot process architecture...
  65. doi Platelet-derived growth factor receptor kinase inhibitor AG-1295 promotes osteoblast differentiation in MC3T3-E1 cells via the Erk pathway
    Y Y Zhang
    Shandong Academy of Medical Sciences, Shandong Medical Biotechnological Center, Key Laboratory for Rare Disease Research of Shandong Province, Ji Nan, Shandong, China
    Biosci Trends 6:130-5. 2012
    Previous studies have conflicting views on the effect of platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling on osteogenesis...
  66. pmc p19Arf represses platelet-derived growth factor receptor β by transcriptional and posttranscriptional mechanisms
    Ryan C Widau
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, Illinois, USA
    Mol Cell Biol 32:4270-82. 2012
    ..p19(Arf) plays an essential role in blocking signals stemming from platelet-derived growth factor receptor β (Pdgfrβ) during eye development, but the underlying mechanisms have not been clear...
  67. pmc A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy
    Shalini Jadeja
    MRC Human Genetics Unit, MRC Institute of Genetics and and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Invest Ophthalmol Vis Sci 54:3569-78. 2013
    ..We aimed to identify the causal mutation in redeye, and evaluate it as a model for diabetic retinopathy (DR)...
  68. pmc Foxc1 is required by pericytes during fetal brain angiogenesis
    Julie A Siegenthaler
    Department of Neurology, Programs in Neuroscience and Developmental Biology, Institute for Regenerative Medicine, UC San Francisco, San Francisco, CA 94158, USA Present address Department of Pediatrics, Denver Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
    Biol Open 2:647-59. 2013
    ..Collectively these data point towards an important role for Foxc1 in certain brain pericyte functions (e.g. vessel morphogenesis) but not others (e.g. barriergenesis). ..
  69. ncbi Developmental distribution of platelet-derived growth factor in the mouse central nervous system
    J B Hutchins
    Department of Anatomy, University of Mississippi Medical Center, Jackson 39216 4505
    Brain Res Dev Brain Res 67:121-35. 1992
    ..By E15, both PDGF isoform and PDGF receptor beta subunit immunoreactivity have declined to near-background levels in the sensory ganglia, while in the spinal cord and developing forebrain, levels of all PDGF-related proteins remain high...
  70. ncbi A multipoint genetic linkage map of mouse chromosome 18
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 13:1143-9. 1992
    ..3-Tpi-10-11.8-(Egr-1, Hmg17-rs9)-2.1-Fgfa-2.2-Grl-1-10.1-(Cdx-1, Csfmr, Pdgfrb, Pdea, Rps14)-2.1-Adrb-2-22.9-Mbp...
  71. pmc A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human
    A M Buchberg
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genetics 122:153-61. 1989
    ..and the known linkage homologies that exist between murine chromosome 11 and human chromosomes (Mpo, Ngfr, Pdgfr and Fms). Two of the latter genes, Mpo and Ngfr, mapped to mouse chromosome 11...
  72. ncbi Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation
    M C Bidwell
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 136:5189-201. 1995
    ....
  73. ncbi Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes
    S Shafqat
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Pharmacol 48:219-29. 1995
    ..These findings warrant the consideration of a synaptic regulatory role for this transporter and its presumed natural substrate, L-proline, in the mammalian central nervous system...
  74. ncbi SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
    G S Feng
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Science 259:1607-11. 1993
    ..The Syp gene is widely expressed throughout embryonic mouse development and in adult tissues. Thus, Syp may function in mammalian embryonic development and as a common target of both receptor and nonreceptor tyrosine kinases...
  75. ncbi The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding
    M A Broome
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Oncogene 14:17-34. 1997
    ..However, Tyr 138 phosphorylation was found to diminish SH3 domain peptide ligand binding ability in vitro...
  76. ncbi Isolation and characterization of the platelet-derived growth factor beta receptor promoter
    E Shinbrot
    Daiichi Research Center, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Dev Dyn 208:211-9. 1997
    ..The further analysis of this promoter will help elucidate the transcriptional regulation of expression of the PDGFbeta r, and provide a useful tool for directing expression of heterologous genes...
  77. ncbi Nuclear factor Y controls the basal transcription activity of the mouse platelet-derived-growth-factor beta-receptor gene
    A Ishisaki
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Eur J Biochem 246:142-6. 1997
    ..The binding proteins were affinity purified and identified as the NF-Y transcription factor by western blotting. Our results indicate that NF-Y controls the basal transcription activity of the mouse PDGF beta-receptor gene...
  78. ncbi Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain
    S Miyake
    Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:16619-28. 1999
    ..compromised the PDGF-inducible tyrosine phosphorylation of Cbl although this mutant could still associate with the PDGFR. More importantly, the G306E mutation abrogated the ability of Cbl to enhance the ligand-induced ubiquitination ..
  79. ncbi The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic mice
    K A Ritchie
    Medical Research Service, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Leukemia 13:1790-803. 1999
    ..This murine model of CMML parallels a myeloproliferative syndrome in humans and implicates the Tel-PDGFRbeta fusion protein in its pathogenesis...
  80. ncbi PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis
    H Riedel
    Department of Biological Sciences, Wayne State University, Detroit, Michigan, MI 48202, USA
    Oncogene 19:39-50. 2000
    ..We have mapped Y740 as a site of PDGFR beta that is involved in the association with PSM...
  81. ncbi PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor
    E Bergsten
    Ludwig Institute for Cancer Research, Stockholm Branch, PO Box 240, S 171 77 Stockholm, Sweden
    Nat Cell Biol 3:512-6. 2001
    ..The PDGF alpha-receptor (PDGFR-alpha) binds to all three PDGF chains, whereas the beta-receptor (PDGFR-beta) binds only to PDGF-B...
  82. ncbi Sp1 is a key regulator of the PDGF beta-receptor transcription
    C Molander
    Institute of Anatomy and Cell Biology, Goteborg University, Gothenburg, Sweden
    Mol Biol Rep 28:223-33. 2001
    ..However, we could not find any effect of Sp1 in the c-Myc-mediated repression on the PFDGF beta-receptor promoter, since the deletion of SpI binding sites could not attenuate the repression by c-Myc on the promoter activity...
  83. ncbi p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y
    Anders Hackzell
    Department of Cell Biology, Institute of Anatomy and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
    J Biol Chem 277:39769-76. 2002
    ..Our results indicate that serum stimulation induces c-Myc and p73alpha, leading to the down-regulation of PDGF beta-receptor expression by repressing its transcription...
  84. pmc Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins
    Joseph H McCarty
    Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 22:7667-77. 2002
    ..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
  85. ncbi S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)
    Linnea M Baudhuin
    Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 18:341-3. 2004
    ..In addition, S1P-stimulated activation of Akt, but not ERK, was blocked by a PDGF receptor (PDGFR)-specific inhibitor, AG1296, suggesting a S1P3-mediated specific crosstalk between the Akt signaling pathways of ..
  86. pmc Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase
    Camilla Persson
    Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, S 751 24 Uppsala, Sweden
    Mol Cell Biol 24:2190-201. 2004
    ..In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors...
  87. ncbi Forced expression of platelet-derived growth factor B in the mouse cerebellar primordium changes cell migration during midline fusion and causes cerebellar ectopia
    Johanna Andrae
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Mol Cell Neurosci 26:308-21. 2004
    ..b>PDGFR-alpha- and laminin alpha1-positive meningeal cells migrated inwards, attracted by the ectopic transgene expression ..
  88. ncbi Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
    Tatiana V Petrova
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Nat Med 10:974-81. 2004
    ..Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD...
  89. ncbi The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
    Xiaowei Lu
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nature 432:179-86. 2004
    ..Netrin-1 causes endothelial filopodial retraction, but only when UNC5B is present. Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system...
  90. ncbi Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells
    Christine Rampon
    Laboratoire Développement et Vieillissement de l Endothélium CEA Inserm EMI 0219, Grenoble, France
    Exp Cell Res 302:48-60. 2005
    ..We conclude that PCDH12 has a unique expression pattern and that its deficiency does not lead to conspicuous abnormalities. Moreover, PCDH12 is the first specific marker for both glycogen-rich trophoblasts and mesangial cells...
  91. ncbi Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages
    Bent Brachvogel
    Department of Cell and Matrix Biology, MCRI, 3052 Parkville Victoria, Australia
    Development 132:2657-68. 2005
    ..Hence, Anxa5 expression in perivascular cells from mouse defines a novel population of cells with a distinct developmental potential...
  92. ncbi Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
    Min Hee Choi
    Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
    Nature 435:347-53. 2005
    ..Prx II deficiency results in increased production of H2O2, enhanced activation of PDGF receptor (PDGFR) and phospholipase Cgamma1, and subsequently increased cell proliferation and migration in response to PDGF...
  93. ncbi Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation
    Alagarsamy Lakku Reddi
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:29336-47. 2007
    ..Cbl as an E3 ubiquitin ligase for ubiquitinylation and degradation of platelet-derived growth factor receptor (PDGFR) alpha and PDGFRbeta...
  94. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
  95. ncbi Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells
    Brent Wagner
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Am Soc Nephrol 18:2903-11. 2007
    Mice deficient in either platelet-derived growth factor (PDGF) B chain or PDGF receptor (PDGFR) beta lack mesangial cells...
  96. pmc Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma
    Shioto Suzuki
    Ludwig Institute for Cancer Research, Uppsala Branch, Uppsala, Sweden
    BMC Cancer 7:224. 2007
    Platelet-derived growth factor (PDGF)-BB and PDGF receptor (PDGFR)-beta are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-beta is expressed by mural cells, including pericytes...
  97. doi Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein
    Vivian Y H Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:7745-53. 2008
    ....
  98. doi Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut
    M Kurahashi
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya, Japan
    Neurogastroenterol Motil 20:521-31. 2008
    ..The selective PDGF receptor inhibitor AG1295 suppressed the differentiation of LMC in gut explants. We conclude that PDGF signals play critical roles in the differentiation of LMC in mouse embryonic gut...
  99. doi A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  100. doi Platelet-derived growth factor receptor beta-subtype regulates proliferation and migration of gonocytes
    Sabrina Basciani
    Department of Medical Physiopathology, Sapienza University, Policlinico Umberto I, 00161 Rome, Italy
    Endocrinology 149:6226-35. 2008
    ..0 (E18) and up to P5, the gonocytes express platelet-derived growth factor (PDGF) receptor beta-subtype (PDGFR-beta) and that during the same time period, the Sertoli cells express PDGF-B and PDGF-D, both ligands for PDGFR-..
  101. pmc Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli
    Rui Benedito
    Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisboa, Portugal
    BMC Dev Biol 8:117. 2008
    ..Dll4 null embryos die very early in development with severely reduced arterial calibre and lumen and loss of arterial cell identity...

Research Grants7

  1. MEDIATORS OF BLOOD-RETINAL BARRIER BREAKDOWN
    STANLEY VINORES; Fiscal Year: 2002
    ....
  2. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  3. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  4. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  5. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2008
    ..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..
  6. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  7. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..