Genomes and Genes
Gene Symbol: Pdgfrb
Description: platelet derived growth factor receptor, beta polypeptide
Alias: AI528809, CD140b, PDGFR-1, Pdgfr, platelet-derived growth factor receptor beta, CD140 antigen-like family member B, PDGF beta chain, PDGF-R-beta, PDGFR-beta, beta platelet-derived growth factor receptor, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor beta variant 1
Publications132 found, 100 shown here
- Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruliP Lindahl
Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
Development 125:3313-22. 1998....
- Platelet-derived growth factor receptor signalsL Claesson-Welsh
Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
J Biol Chem 269:32023-6. 1994
- Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant miceP Soriano
Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
Genes Dev 8:1888-96. 1994..These results indicate that whereas the beta receptor is essential in certain cell types during embryonic development, its broader role may be masked because of compensation by the alpha-subunit...
- Regulation of chemotaxis by the platelet-derived growth factor receptor-betaV Kundra
Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
Nature 367:474-6. 1994..Upon stimulation, the tyrosine kinase PDGF receptor-beta (PDGFR-beta) autophosphorylates and forms a complex that includes SII2(Src homology 2)-domain-containing proteins such as ..
- Pericyte loss and microaneurysm formation in PDGF-B-deficient miceP Lindahl
Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
Science 277:242-5. 1997..Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts...
- Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouseM Hellstrom
Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
Development 126:3047-55. 1999..we used desmin and alpha-smooth muscle actin (ASMA) as markers to analyze vSMC/PC development in PDGF-B-/- and PDGFR-beta-/- embryos. Both mutants showed a site-specific reduction of desmin-positive pericytes and ASMA-positive vSMC...
- PDGFB regulates the development of the labyrinthine layer of the mouse fetal placentaR Ohlsson
Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, Uppsala, S 752 36, Sweden
Dev Biol 212:124-36. 1999..We point out that the roles of PDGFB/Rbeta signaling in the placenta may be analogous to those in the developing kidney, by controlling pericytes in the labyrinthine layer and mesangial cells in the kidney...
- Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signalingR Heuchel
Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S 75124 Uppsala, Sweden
Proc Natl Acad Sci U S A 96:11410-5. 1999..Taken together, these observations suggest a function for PDGF signaling through PI3K in interstitial fluid homeostasis by modulating the tension between cells and extracellular matrix structures...
- Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathwaysM D Tallquist
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genes Dev 14:3179-90. 2000Signal transduction by the platelet-derived growth-factor receptor beta (PDGFR-beta) tyrosine kinase is required for proper formation of vascular smooth muscle cells (VSMC)...
- Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesisM Hellstrom
Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
J Cell Biol 153:543-53. 2001..Here, we addressed these issues using PDGF-B-- and PDGF receptor-beta (PDGFR-beta)--deficient mice as in vivo models of brain angiogenesis in the absence of PCs...
- An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during developmentRichard A Klinghoffer
Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Dev Cell 2:103-13. 2002..Our results indicate that PI3K has a predominant role in PDGFalphaR signaling in vivo and that RTK-activated signaling pathways execute both specific and overlapping functions during mammalian development...
- Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell developmentMichelle D Tallquist
Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
PLoS Biol 1:E52. 2003..The combined in vivo and biochemical data suggest that the summation of pathways associated with the PDGFRbeta signal transduction determines the expansion of developing v/p cells...
- Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptorRina Plattner
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell Biol 24:2573-83. 2004..signals such as the platelet-derived growth factor (PDGF) and functions downstream of the PDGF-beta receptor (PDGFR) to mediate biological processes such as membrane ruffling, mitogenesis, and chemotaxis...
- A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activityFederica Chiara
Ludwig Institute for Cancer Research, Box 595, Uppsala S 751 24, Sweden
J Biol Chem 279:42516-27. 2004..Our findings support a model whereby an activating point mutation results in a deregulated PDGFRbeta with oncogenic predisposition...
- Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healingZhiyang Gao
Department of Pathology, Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
J Biol Chem 280:9375-89. 2005This study provides new perspectives of the unique aspects of platelet-derived growth factor beta-receptor (PDGFR-beta) signaling and biological responses through the establishment of a mutant mouse strain in which two loxP sequences ..
- Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assemblyShane S Foo
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
Cell 124:161-73. 2006..Our results indicate that the role of ephrin-B2 and EphB receptors in these processes involves Crk-p130(CAS) signaling and suggest that ephrin-B2 has some cell-cell-contact-independent functions...
- Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injuryYoko Ishii
Department of Pathology, Faculty of Medicine, University of Toyama, Toyama, Japan
J Neurochem 98:588-600. 2006..Here, we developed novel mutant mice in which the gene encoding the beta subunit of PDGFR (PDGFR-beta) was genetically deleted in CNS neurons to elucidate the role of PDGFR-beta, particularly in the post-..
- Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytesCecilia Bondjers
Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
FASEB J 20:1703-5. 2006..The three new brain pericyte markers are signaling molecules implicated in ion transport and intercellular signaling, potentially opening new windows on pericyte function in brain microvessels...
- Klf2 is an essential regulator of vascular hemodynamic forces in vivoJohn S Lee
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Dev Cell 11:845-57. 2006..These findings identify Klf2 as an essential hemodynamic regulator in vivo and suggest that hemodynamic regulation in response to fluid shear stress is required for cardiovascular development and function...
- Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal miceYoko Ishii
Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
Mol Cell Neurosci 37:507-18. 2008..the ventricular and the subventricular zones (SVZ) of newborn mice to stain positive for the PDGF beta-receptor (PDGFRB)...
- Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expressionShinya Yamamoto
Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
J Biol Chem 283:23139-49. 2008..Thus, PDGF signaling is a possible mechanism involved in the interaction between epithelial and neural crest-derived mesenchyme...
- The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculatureYoshitsugu Takabatake
Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine B6, Suita, Japan
J Am Soc Nephrol 20:1714-23. 2009..We conclude that CXCL12 secreted from stromal cells or podocytes acts on endothelial cells to regulate vascular development in the kidney. These findings suggest new potential therapeutic targets for remodeling the injured kidney...
- Foxn1 is essential for vascularization of the murine thymus anlageKazuya Mori
Department of Immunology and Microbiology, Meiji University of Integrative Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
Cell Immunol 260:66-9. 2010..The present results indicate that Foxn1 dependent epithelial development is essential for vascularization of the thymus anlagen...
- Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involvedLianshun Zheng
Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
J Neurosci Res 88:1273-84. 2010..The specific function of the PDGF beta-receptor (PDGFR-beta) was examined by the selective deletion of the corresponding gene using the Cre-loxP system in vitro...
- Pericytes are required for blood-brain barrier integrity during embryogenesisRichard Daneman
UCSF Department of Anatomy, 513 Parnassus Avenue, HSW1301, San Francisco, California 94143 0452, USA
Nature 468:562-6. 2010..Analysing mice with null and hypomorphic alleles of Pdgfrb, which have defects in pericyte generation, we demonstrate that pericytes are necessary for the formation of the ..
- Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain agingRobert D Bell
Department of Neurosurgery and Neurology, University of Rochester Medical Center, Center for Neurodegenerative and Vascular Brain Disorders, Rochester, NY 14642, USA
Neuron 68:409-27. 2010..Thus, pericytes control key neurovascular functions that are necessary for proper neuronal structure and function, and pericyte loss results in a progressive age-dependent vascular-mediated neurodegeneration...
- Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout micePhuong Thi Hong Nguyen
System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
PLoS ONE 6:e18004. 2011Platelet-derived growth factor (PDGF) is a potent mitogen. Extensive in vivo studies of PDGF and its receptor (PDGFR) genes have reported that PDGF plays an important role in embryogenesis and development of the central nervous system (..
- Perlecan maintains microvessel integrity in vivo and modulates their formation in vitroErika Gustafsson
Department of Experimental Pathology, Lund University, Lund, Sweden
PLoS ONE 8:e53715. 2013..Altogether these findings suggest that perlecan supports the maintenance of brain and skin subendothelial BMs and promotes vasculo- and angiogenesis by modulating FGF-2 function...
- FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidneyJennifer L Fetting
Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
Development 141:17-27. 2014....
- Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney developmentScott C Boyle
Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
Development 141:346-54. 2014..Interestingly, Pdgfrb-positive VSMCs do not enter the vascular cleft and cannot rescue the mesangial deficiency...
- The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functionsR A Klinghoffer
Program in Developmental Biology and Division, Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Mol Cell 7:343-54. 2001..we have created two complementary lines of knockin mice in which the intracellular signaling domains of one PDGFR have been removed and replaced by those of the other PDGFR...
- Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiationCharlotte Rolny
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv 20, 751 85 Uppsala, Sweden
Blood 108:1877-86. 2006..Here we present data indicating that early hematopoietic/endothelial (hemangio) precursors express PDGFR-beta based on coexpression with CD31, vascular endothelial growth factor receptor-2, and CD41 in 2 models: mouse ..
- Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healingVineeth S Rajkumar
Centre for Rheumatology and Connective Tissue Disease, Department of Medicine, University College London NW3 2PF, UK, and the Clinical Research Center, University Hospital, Orebro, Sweden
Am J Pathol 169:2254-65. 2006..platelet-derived growth factor receptor-beta blockade in vivo using the platelet-derived growth factor receptor (PDGFR)-beta inhibitor imatinib mesylate on tissue repair...
- Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidneyR A Seifert
Department of Pathology, University of Washington, Seattle 98195, USA
Kidney Int 54:731-46. 1998..To understand potential PDGF signaling pathways in the kidney, we determined the expression pattern of PDGF ligand and receptor genes in mouse kidney during development and in the mature adult kidney...
- Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptorsG Alonso
Differentiation Programme, European Molecular Biology Laboratory, Heidelberg, Germany
J Biol Chem 270:9840-8. 1995..These observations support a model in which the enzymatic activity of Src family tyrosine kinases is controlled by intra- and intermolecular interactions of tyrosine-phosphorylated peptides with the SH2 domain of the kinases...
- Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten miceM Kozlowski
Department of Medicine, University of Toronto, Ontario, Canada
J Exp Med 178:2157-63. 1993..These observations provide strong evidence that the motheaten phenotypic results from loss-of-function mutations in the PTP1C gene and imply a critical role for PTP1C in the regulation of hemopoietic differentiation and immune function...
- Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutationB McCright
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Development 128:491-502. 2001..These data identify novel developmental roles for Notch2 in kidney, heart and eye development...
- Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cellsCecilia Bondjers
Department of Medical Biochemistry, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Am J Pathol 162:721-9. 2003..Absence of RGS5 expression in PDGF-B and PDGFR beta-null embryos correlated with pericyte loss in these mice...
- Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient miceJolanta E Pitera
Institute of Child Health, University College London, London, UK
Am J Pathol 165:1895-906. 2004..In wild-type neonates, alpha smooth muscle actin (alpha SMA), platelet-derived growth factor receptor beta (PDGFR beta), and desmin-expressing cells were not prominent in this compartment...
- PI3K is involved in PDGF-beta receptor upregulation post-PDGF-BB treatment in mouse HSCCarmen G Lechuga
Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
Am J Physiol Gastrointest Liver Physiol 291:G1051-61. 2006..We also showed that receptor reappearance is time and dose dependent, being more delayed in cells treated with 50 ng/ml (48 h) compared with 10 ng/ml (24 h)...
- Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesisFrank Kuhnert
Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:10185-90. 2008..These studies using highly specific soluble receptors suggest that additivity between VEGFR and PDGFRbeta inhibition depends on the strength of VEGF blockade and appears minimal under conditions of maximal VEGF antagonism...
- Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populationsAmy M Mellgren
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Circ Res 103:1393-401. 2008..To investigate the role of platelet-derived growth factor receptor (PDGFR)beta in development of epicardial-derived vascular smooth muscle cells (VSMCs), we examined PDGFRbeta(-/-) and ..
- Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cellsErxi Wu
Informatics Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 3:e3794. 2008..we used wild-type mouse embryonic fibroblasts (MEF), MEF null for either PDGFRalpha, beta, or both to dissect PDGF-PDGFR signaling pathways...
- The PDGF signaling pathway controls multiple steroid-producing lineagesJennifer Schmahl
Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Genes Dev 22:3255-67. 2008..Therefore, PDGF signaling may constitute a common mechanism in the control of multiple steroidogenic lineages...
- Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularizationC Guignabert
Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford Univ School of Medicine, CA 94305 5162, USA
Am J Physiol Lung Cell Mol Physiol 297:L1082-90. 2009..Thus the disruption of PPARgamma signaling in EC is sufficient to cause mild PAH and to impair recovery from CH-induced PAH. Inhibition of heightened PDGF-Rbeta signaling is sufficient to reverse PAH in this genetic model...
- Dimerization drives PDGF receptor endocytosis through a C-terminal hydrophobic motif shared by EGF receptorJustin Pahara
Department of Cell Biology and Signal Transduction Research Group, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
Exp Cell Res 316:2237-50. 2010Like many other receptor tyrosine kinases (RTKs), platelet-derived growth factor (PDGF) receptor beta (PDGFR-beta) is internalized and degraded in lysosomes in response to PDGF stimulation, which regulates many aspects of cell signalling...
- Platelet-derived growth factor (PDGF)-BB produces NO-mediated relaxation and PDGF receptor β-dependent tonic contraction in murine iliac lymph vesselsDaisuke Maejima
Department of Physiology, Shinshu University School of Medicine, Matsumoto, Japan
Microcirculation 18:474-86. 2011..PDGF receptor β-mediated tonic contraction of the muscles through increased Ca(2+) influx through the membrane and the release of membrane-bound and intracellular Ca(2+) ...
- A novel function for platelet-derived growth factor D: induction of osteoclastic differentiation for intraosseous tumor growthW Huang
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA
Oncogene 31:4527-35. 2012Although increasing evidence suggests a critical role for platelet-derived growth factor (PDGF) receptor β (β-PDGFR) signaling in prostate cancer (PCa) progression, the precise roles of β-PDGFR and PDGF isoform-specific cell signaling ..
- Trophoblasts regulate the placental hematopoietic niche through PDGF-B signalingAkanksha Chhabra
Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA
Dev Cell 22:651-9. 2012..Loss of PDGF-B or its receptor, PDGFRβ, induced definitive erythropoiesis in placental labyrinth vasculature...
- Predominant role of PDGF receptor transactivation in Wnt3a-induced osteoblastic cell proliferationJoseph Caverzasio
Service of Bone Diseases, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland
J Bone Miner Res 28:260-70. 2013....
- Combined inhibition of c-Abl and PDGF receptors for prevention and treatment of murine sclerodermatous chronic graft-versus-host diseasePawel Zerr
Department of Internal Medicine III, University of Erlangen Nuremberg, Germany
Am J Pathol 181:1672-80. 2012..the effects of the combined inhibition of the Abelson kinase (c-Abl) and platelet-derived growth factor receptors (PDGFR) in experimental sclerodermatous cGvHD...
- Thymosin β4 is not required for embryonic viability or vascular developmentIndroneal Banerjee
Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Circ Res 112:e25-8. 2013..These data are in direct contrast to our published global and cardiac-specific Tβ4-knockout lines. Thus, the role of Tβ4 needs to be clarified to understand its importance in cardiovascular development...
- Lymphatic function is required prenatally for lung inflation at birthZoltan Jakus
Department of Medicine, 2 Cardiovascular Institute, and 3 Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104
J Exp Med 211:815-26. 2014..They explain respiratory failure in infants with congenital pulmonary lymphangiectasia, and suggest that inadequate late gestation lymphatic function may also contribute to respiratory failure in premature infants. ..
- Cited2 is required in trophoblasts for correct placental capillary patterningJulie L M Moreau
Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Sydney, Australia Electronic address
Dev Biol 392:62-79. 2014....
- Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formationChristopher J Turner
Howard Hughes Medical Institute, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Dev Biol 392:381-92. 2014..Here, we report that deletion of the gene encoding the integrin-α5 subunit (Itga5) using the Pdgfrb-Cre transgenic mouse line, leads to oedema, haemorrhage and increased levels of embryonic lethality...
- Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic strokeNoriko Makihara
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Japan
Exp Neurol 264:127-34. 2015..Here, we examined whether platelet-derived growth factor receptor β (PDGFRβ), a well-known indispensable molecule for migration, proliferation, and survival of pericytes, was involved in ..
- Pericytes are progenitors for coronary artery smooth muscleKatharina S Volz
Stem Cell and Regenerative Medicine PhD Program, Stanford School of Medicine, Stanford, United States
elife 4:. 2015..Our data are the first demonstration that pericytes are progenitors for smooth muscle, and their presence in adult hearts reveals a new potential cell type for targeting during cardiovascular disease. ..
- Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous originsMaria H Ulvmar
Department of Immunology Genetics and Pathology, Uppsala University, Dag Hammarskjöldsväg 20, 751 85, Uppsala, Sweden
Genesis 54:350-8. 2016The Pdgfrb-Cre line has been used as a tool to specifically target pericytes and vascular smooth muscle cells...
- PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemiaJie Shen
Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
J Cereb Blood Flow Metab 32:353-67. 2012..We investigated the role of PDGFR-β in tissue responses and functional recovery after photothrombolic middle cerebral artery occlusion (MCAO)...
- Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 proteinYuri Fukumoto
Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
J Biol Chem 286:43537-48. 2011..These results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac...
- PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cellsYuan Xue
Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
Nat Med 18:100-10. 2011..EPO) mRNA and protein expression by targeting stromal and perivascular cells that express PDGF receptor-β (PDGFR-β)...
- The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescenceJorge Ivan Alvarez
Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
Science 334:1727-31. 2011..Overall, the Hh pathway provides a barrier-promoting effect and an endogenous anti-inflammatory balance to CNS-directed immune attacks, as occurs in multiple sclerosis...
- Death receptors DR6 and TROY regulate brain vascular developmentStephen J Tam
Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
Dev Cell 22:403-17. 2012..These findings define a role for death receptors DR6 and TROY in CNS-specific vascular development...
- Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structureXueping Fan
Renal Section, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
Cell Rep 2:52-61. 2012..These results suggest that Robo2 signaling acts as a negative regulator on nephrin to influence podocyte foot process architecture...
- Platelet-derived growth factor receptor kinase inhibitor AG-1295 promotes osteoblast differentiation in MC3T3-E1 cells via the Erk pathwayY Y Zhang
Shandong Academy of Medical Sciences, Shandong Medical Biotechnological Center, Key Laboratory for Rare Disease Research of Shandong Province, Ji Nan, Shandong, China
Biosci Trends 6:130-5. 2012Previous studies have conflicting views on the effect of platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling on osteogenesis...
- p19Arf represses platelet-derived growth factor receptor β by transcriptional and posttranscriptional mechanismsRyan C Widau
Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, Illinois, USA
Mol Cell Biol 32:4270-82. 2012..p19(Arf) plays an essential role in blocking signals stemming from platelet-derived growth factor receptor β (Pdgfrβ) during eye development, but the underlying mechanisms have not been clear...
- A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathyShalini Jadeja
MRC Human Genetics Unit, MRC Institute of Genetics and and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, United Kingdom
Invest Ophthalmol Vis Sci 54:3569-78. 2013..We aimed to identify the causal mutation in redeye, and evaluate it as a model for diabetic retinopathy (DR)...
- Foxc1 is required by pericytes during fetal brain angiogenesisJulie A Siegenthaler
Department of Neurology, Programs in Neuroscience and Developmental Biology, Institute for Regenerative Medicine, UC San Francisco, San Francisco, CA 94158, USA Present address Department of Pediatrics, Denver Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
Biol Open 2:647-59. 2013..Collectively these data point towards an important role for Foxc1 in certain brain pericyte functions (e.g. vessel morphogenesis) but not others (e.g. barriergenesis). ..
- Developmental distribution of platelet-derived growth factor in the mouse central nervous systemJ B Hutchins
Department of Anatomy, University of Mississippi Medical Center, Jackson 39216 4505
Brain Res Dev Brain Res 67:121-35. 1992..By E15, both PDGF isoform and PDGF receptor beta subunit immunoreactivity have declined to near-background levels in the sensory ganglia, while in the spinal cord and developing forebrain, levels of all PDGF-related proteins remain high...
- A multipoint genetic linkage map of mouse chromosome 18K R Johnson
Jackson Laboratory, Bar Harbor, Maine 04609
Genomics 13:1143-9. 1992..3-Tpi-10-11.8-(Egr-1, Hmg17-rs9)-2.1-Fgfa-2.2-Grl-1-10.1-(Cdx-1, Csfmr, Pdgfrb, Pdea, Rps14)-2.1-Adrb-2-22.9-Mbp...
- A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and humanA M Buchberg
Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
Genetics 122:153-61. 1989..and the known linkage homologies that exist between murine chromosome 11 and human chromosomes (Mpo, Ngfr, Pdgfr and Fms). Two of the latter genes, Mpo and Ngfr, mapped to mouse chromosome 11...
- Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestationM C Bidwell
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Endocrinology 136:5189-201. 1995....
- Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomesS Shafqat
Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Pharmacol 48:219-29. 1995..These findings warrant the consideration of a synaptic regulatory role for this transporter and its presumed natural substrate, L-proline, in the mammalian central nervous system...
- SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinasesG S Feng
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Science 259:1607-11. 1993..The Syp gene is widely expressed throughout embryonic mouse development and in adult tissues. Thus, Syp may function in mammalian embryonic development and as a common target of both receptor and nonreceptor tyrosine kinases...
- The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand bindingM A Broome
Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
Oncogene 14:17-34. 1997..However, Tyr 138 phosphorylation was found to diminish SH3 domain peptide ligand binding ability in vitro...
- Isolation and characterization of the platelet-derived growth factor beta receptor promoterE Shinbrot
Daiichi Research Center, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
Dev Dyn 208:211-9. 1997..The further analysis of this promoter will help elucidate the transcriptional regulation of expression of the PDGFbeta r, and provide a useful tool for directing expression of heterologous genes...
- Nuclear factor Y controls the basal transcription activity of the mouse platelet-derived-growth-factor beta-receptor geneA Ishisaki
Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
Eur J Biochem 246:142-6. 1997..The binding proteins were affinity purified and identified as the NF-Y transcription factor by western blotting. Our results indicate that NF-Y controls the basal transcription activity of the mouse PDGF beta-receptor gene...
- Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domainS Miyake
Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 274:16619-28. 1999..compromised the PDGF-inducible tyrosine phosphorylation of Cbl although this mutant could still associate with the PDGFR. More importantly, the G306E mutation abrogated the ability of Cbl to enhance the ligand-induced ubiquitination ..
- The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic miceK A Ritchie
Medical Research Service, VA Puget Sound Health Care System, Seattle, WA 98108, USA
Leukemia 13:1790-803. 1999..This murine model of CMML parallels a myeloproliferative syndrome in humans and implicates the Tel-PDGFRbeta fusion protein in its pathogenesis...
- PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesisH Riedel
Department of Biological Sciences, Wayne State University, Detroit, Michigan, MI 48202, USA
Oncogene 19:39-50. 2000..We have mapped Y740 as a site of PDGFR beta that is involved in the association with PSM...
- PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptorE Bergsten
Ludwig Institute for Cancer Research, Stockholm Branch, PO Box 240, S 171 77 Stockholm, Sweden
Nat Cell Biol 3:512-6. 2001..The PDGF alpha-receptor (PDGFR-alpha) binds to all three PDGF chains, whereas the beta-receptor (PDGFR-beta) binds only to PDGF-B...
- Sp1 is a key regulator of the PDGF beta-receptor transcriptionC Molander
Institute of Anatomy and Cell Biology, Goteborg University, Gothenburg, Sweden
Mol Biol Rep 28:223-33. 2001..However, we could not find any effect of Sp1 in the c-Myc-mediated repression on the PFDGF beta-receptor promoter, since the deletion of SpI binding sites could not attenuate the repression by c-Myc on the promoter activity...
- p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-YAnders Hackzell
Department of Cell Biology, Institute of Anatomy and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
J Biol Chem 277:39769-76. 2002..Our results indicate that serum stimulation induces c-Myc and p73alpha, leading to the down-regulation of PDGF beta-receptor expression by repressing its transcription...
- Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrinsJoseph H McCarty
Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Mol Cell Biol 22:7667-77. 2002..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
- S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)Linnea M Baudhuin
Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
FASEB J 18:341-3. 2004..In addition, S1P-stimulated activation of Akt, but not ERK, was blocked by a PDGF receptor (PDGFR)-specific inhibitor, AG1296, suggesting a S1P3-mediated specific crosstalk between the Akt signaling pathways of ..
- Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphataseCamilla Persson
Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, S 751 24 Uppsala, Sweden
Mol Cell Biol 24:2190-201. 2004..In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors...
- Forced expression of platelet-derived growth factor B in the mouse cerebellar primordium changes cell migration during midline fusion and causes cerebellar ectopiaJohanna Andrae
Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
Mol Cell Neurosci 26:308-21. 2004..b>PDGFR-alpha- and laminin alpha1-positive meningeal cells migrated inwards, attracted by the ectopic transgene expression ..
- Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasisTatiana V Petrova
Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
Nat Med 10:974-81. 2004..Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD...
- The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular systemXiaowei Lu
Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
Nature 432:179-86. 2004..Netrin-1 causes endothelial filopodial retraction, but only when UNC5B is present. Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system...
- Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cellsChristine Rampon
Laboratoire Développement et Vieillissement de l Endothélium CEA Inserm EMI 0219, Grenoble, France
Exp Cell Res 302:48-60. 2005..We conclude that PCDH12 has a unique expression pattern and that its deficiency does not lead to conspicuous abnormalities. Moreover, PCDH12 is the first specific marker for both glycogen-rich trophoblasts and mesangial cells...
- Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineagesBent Brachvogel
Department of Cell and Matrix Biology, MCRI, 3052 Parkville Victoria, Australia
Development 132:2657-68. 2005..Hence, Anxa5 expression in perivascular cells from mouse defines a novel population of cells with a distinct developmental potential...
- Regulation of PDGF signalling and vascular remodelling by peroxiredoxin IIMin Hee Choi
Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
Nature 435:347-53. 2005..Prx II deficiency results in increased production of H2O2, enhanced activation of PDGF receptor (PDGFR) and phospholipase Cgamma1, and subsequently increased cell proliferation and migration in response to PDGF...
- Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulationAlagarsamy Lakku Reddi
Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
J Biol Chem 282:29336-47. 2007..Cbl as an E3 ubiquitin ligase for ubiquitinylation and degradation of platelet-derived growth factor receptor (PDGFR) alpha and PDGFRbeta...
- Mesenchymal cells are required for functional development of thymic epithelial cellsManami Itoi
Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
Int Immunol 19:953-64. 2007..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
- Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cellsBrent Wagner
Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
J Am Soc Nephrol 18:2903-11. 2007Mice deficient in either platelet-derived growth factor (PDGF) B chain or PDGF receptor (PDGFR) beta lack mesangial cells...
- Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanomaShioto Suzuki
Ludwig Institute for Cancer Research, Uppsala Branch, Uppsala, Sweden
BMC Cancer 7:224. 2007Platelet-derived growth factor (PDGF)-BB and PDGF receptor (PDGFR)-beta are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-beta is expressed by mural cells, including pericytes...
- Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor proteinVivian Y H Hook
Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
J Biol Chem 283:7745-53. 2008....
- Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gutM Kurahashi
Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya, Japan
Neurogastroenterol Motil 20:521-31. 2008..The selective PDGF receptor inhibitor AG1295 suppressed the differentiation of LMC in gut explants. We conclude that PDGF signals play critical roles in the differentiation of LMC in mouse embryonic gut...
- A myocardial lineage derives from Tbx18 epicardial cellsChen Leng Cai
Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
Nature 454:104-8. 2008..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
- Platelet-derived growth factor receptor beta-subtype regulates proliferation and migration of gonocytesSabrina Basciani
Department of Medical Physiopathology, Sapienza University, Policlinico Umberto I, 00161 Rome, Italy
Endocrinology 149:6226-35. 2008..0 (E18) and up to P5, the gonocytes express platelet-derived growth factor (PDGF) receptor beta-subtype (PDGFR-beta) and that during the same time period, the Sertoli cells express PDGF-B and PDGF-D, both ligands for PDGFR-..
- Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuliRui Benedito
Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisboa, Portugal
BMC Dev Biol 8:117. 2008..Dll4 null embryos die very early in development with severely reduced arterial calibre and lumen and loss of arterial cell identity...
- MEDIATORS OF BLOOD-RETINAL BARRIER BREAKDOWNSTANLEY VINORES; Fiscal Year: 2002....
- Proteomics/Genomics of Opiate Analgesia and AddictionVivian Hook; Fiscal Year: 2004..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
- INTEGRATED DNA SEQUENCING SYSTEMVivian Hook; Fiscal Year: 2002..abstract_text> ..
- Serpin Protease Inhibitors & Opioid NeuropeptidesVivian Hook; Fiscal Year: 2006..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
- Is non-canonical Wnt signaling required in cardiac neural crest cells?Ethan David Cohen; Fiscal Year: 2008..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..
- POMC Processing and Beta-Endorphine-Related Opioid PeptidesVivian Y H Hook; Fiscal Year: 2010..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
- BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDESVivian Hook; Fiscal Year: 2009..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..