Pdgfrb

Summary

Gene Symbol: Pdgfrb
Description: platelet derived growth factor receptor, beta polypeptide
Alias: AI528809, CD140b, PDGFR-1, Pdgfr, CD140 antigen-like family member B, PDGF beta chain, PDGF-R-beta, PDGFR-beta, beta platelet-derived growth factor receptor, beta-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 1, platelet-derived growth factor receptor beta, platelet-derived growth factor receptor beta variant 1
Species: mouse

Top Publications

  1. ncbi Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
    P Lindahl
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 125:3313-22. 1998
  2. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
  3. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
  4. pmc The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine B6, Suita, Japan
    J Am Soc Nephrol 20:1714-23. 2009
  5. ncbi Platelet-derived growth factor receptor signals
    L Claesson-Welsh
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    J Biol Chem 269:32023-6. 1994
  6. pmc Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling
    R Heuchel
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S 75124 Uppsala, Sweden
    Proc Natl Acad Sci U S A 96:11410-5. 1999
  7. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
  8. ncbi Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
    P Soriano
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genes Dev 8:1888-96. 1994
  9. ncbi A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity
    Federica Chiara
    Ludwig Institute for Cancer Research, Box 595, Uppsala S 751 24, Sweden
    J Biol Chem 279:42516-27. 2004
  10. ncbi An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development
    Richard A Klinghoffer
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 2:103-13. 2002

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Detail Information

Publications98

  1. ncbi Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
    P Lindahl
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 125:3313-22. 1998
    ....
  2. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
    ..Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts...
  3. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
    ..Here, we addressed these issues using PDGF-B-- and PDGF receptor-beta (PDGFR-beta)--deficient mice as in vivo models of brain angiogenesis in the absence of PCs...
  4. pmc The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature
    Yoshitsugu Takabatake
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine B6, Suita, Japan
    J Am Soc Nephrol 20:1714-23. 2009
    ..We conclude that CXCL12 secreted from stromal cells or podocytes acts on endothelial cells to regulate vascular development in the kidney. These findings suggest new potential therapeutic targets for remodeling the injured kidney...
  5. ncbi Platelet-derived growth factor receptor signals
    L Claesson-Welsh
    Ludwig Institute for Cancer Research, Uppsala Branch, Sweden
    J Biol Chem 269:32023-6. 1994
  6. pmc Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling
    R Heuchel
    Ludwig Institute for Cancer Research, Box 595, Biomedical Center, S 75124 Uppsala, Sweden
    Proc Natl Acad Sci U S A 96:11410-5. 1999
    ..Taken together, these observations suggest a function for PDGF signaling through PI3K in interstitial fluid homeostasis by modulating the tension between cells and extracellular matrix structures...
  7. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
    ..we used desmin and alpha-smooth muscle actin (ASMA) as markers to analyze vSMC/PC development in PDGF-B-/- and PDGFR-beta-/- embryos. Both mutants showed a site-specific reduction of desmin-positive pericytes and ASMA-positive vSMC...
  8. ncbi Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
    P Soriano
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genes Dev 8:1888-96. 1994
    ..These results indicate that whereas the beta receptor is essential in certain cell types during embryonic development, its broader role may be masked because of compensation by the alpha-subunit...
  9. ncbi A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity
    Federica Chiara
    Ludwig Institute for Cancer Research, Box 595, Uppsala S 751 24, Sweden
    J Biol Chem 279:42516-27. 2004
    ..Our findings support a model whereby an activating point mutation results in a deregulated PDGFRbeta with oncogenic predisposition...
  10. ncbi An allelic series at the PDGFalphaR locus indicates unequal contributions of distinct signaling pathways during development
    Richard A Klinghoffer
    Program in Developmental Biology, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Dev Cell 2:103-13. 2002
    ..Our results indicate that PI3K has a predominant role in PDGFalphaR signaling in vivo and that RTK-activated signaling pathways execute both specific and overlapping functions during mammalian development...
  11. doi Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved
    Lianshun Zheng
    Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan
    J Neurosci Res 88:1273-84. 2010
    ..The specific function of the PDGF beta-receptor (PDGFR-beta) was examined by the selective deletion of the corresponding gene using the Cre-loxP system in vitro...
  12. doi Characterization of neuroprogenitor cells expressing the PDGF beta-receptor within the subventricular zone of postnatal mice
    Yoko Ishii
    Institute of Biomedicine, Department of Medical Chemistry and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
    Mol Cell Neurosci 37:507-18. 2008
    ..the ventricular and the subventricular zones (SVZ) of newborn mice to stain positive for the PDGF beta-receptor (PDGFRB)...
  13. ncbi PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta
    R Ohlsson
    Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, Uppsala, S 752 36, Sweden
    Dev Biol 212:124-36. 1999
    ..We point out that the roles of PDGFB/Rbeta signaling in the placenta may be analogous to those in the developing kidney, by controlling pericytes in the labyrinthine layer and mesangial cells in the kidney...
  14. pmc Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways
    M D Tallquist
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genes Dev 14:3179-90. 2000
    Signal transduction by the platelet-derived growth-factor receptor beta (PDGFR-beta) tyrosine kinase is required for proper formation of vascular smooth muscle cells (VSMC)...
  15. ncbi Regulation of chemotaxis by the platelet-derived growth factor receptor-beta
    V Kundra
    Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115
    Nature 367:474-6. 1994
    ..Upon stimulation, the tyrosine kinase PDGF receptor-beta (PDGFR-beta) autophosphorylates and forms a complex that includes SII2(Src homology 2)-domain-containing proteins such as ..
  16. ncbi Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation
    Charlotte Rolny
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjoldsv 20, 751 85 Uppsala, Sweden
    Blood 108:1877-86. 2006
    ..Here we present data indicating that early hematopoietic/endothelial (hemangio) precursors express PDGFR-beta based on coexpression with CD31, vascular endothelial growth factor receptor-2, and CD41 in 2 models: mouse ..
  17. ncbi The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions
    R A Klinghoffer
    Program in Developmental Biology and Division, Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Mol Cell 7:343-54. 2001
    ..we have created two complementary lines of knockin mice in which the intracellular signaling domains of one PDGFR have been removed and replaced by those of the other PDGFR...
  18. pmc Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing
    Vineeth S Rajkumar
    Centre for Rheumatology and Connective Tissue Disease, Department of Medicine, University College London NW3 2PF, UK, and the Clinical Research Center, University Hospital, Orebro, Sweden
    Am J Pathol 169:2254-65. 2006
    ..platelet-derived growth factor receptor-beta blockade in vivo using the platelet-derived growth factor receptor (PDGFR)-beta inhibitor imatinib mesylate on tissue repair...
  19. ncbi Expression of platelet-derived growth factor and its receptors in the developing and adult mouse kidney
    R A Seifert
    Department of Pathology, University of Washington, Seattle 98195, USA
    Kidney Int 54:731-46. 1998
    ..To understand potential PDGF signaling pathways in the kidney, we determined the expression pattern of PDGF ligand and receptor genes in mouse kidney during development and in the mature adult kidney...
  20. pmc Foxc1 is required by pericytes during fetal brain angiogenesis
    Julie A Siegenthaler
    Department of Neurology, Programs in Neuroscience and Developmental Biology, Institute for Regenerative Medicine, UC San Francisco, San Francisco, CA 94158, USA Present address Department of Pediatrics, Denver Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA
    Biol Open 2:647-59. 2013
    ..Collectively these data point towards an important role for Foxc1 in certain brain pericyte functions (e.g. vessel morphogenesis) but not others (e.g. barriergenesis). ..
  21. doi Platelet-derived growth factor receptor kinase inhibitor AG-1295 promotes osteoblast differentiation in MC3T3-E1 cells via the Erk pathway
    Y Y Zhang
    Shandong Academy of Medical Sciences, Shandong Medical Biotechnological Center, Key Laboratory for Rare Disease Research of Shandong Province, Ji Nan, Shandong, China
    Biosci Trends 6:130-5. 2012
    Previous studies have conflicting views on the effect of platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling on osteogenesis...
  22. pmc A CNS-specific hypomorphic Pdgfr-beta mutant model of diabetic retinopathy
    Shalini Jadeja
    MRC Human Genetics Unit, MRC Institute of Genetics and and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Invest Ophthalmol Vis Sci 54:3569-78. 2013
    ..We aimed to identify the causal mutation in redeye, and evaluate it as a model for diabetic retinopathy (DR)...
  23. pmc Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure
    Xueping Fan
    Renal Section, Department of Medicine, Boston University Medical Center, Boston, MA 02118, USA
    Cell Rep 2:52-61. 2012
    ..These results suggest that Robo2 signaling acts as a negative regulator on nephrin to influence podocyte foot process architecture...
  24. doi Death receptors DR6 and TROY regulate brain vascular development
    Stephen J Tam
    Neurodegeneration Labs, Department of Neuroscience, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Dev Cell 22:403-17. 2012
    ..These findings define a role for death receptors DR6 and TROY in CNS-specific vascular development...
  25. doi The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence
    Jorge Ivan Alvarez
    Neuroimmunology Unit, Center of Excellence in Neuromics, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Science 334:1727-31. 2011
    ..Overall, the Hh pathway provides a barrier-promoting effect and an endogenous anti-inflammatory balance to CNS-directed immune attacks, as occurs in multiple sclerosis...
  26. doi PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
    Yuan Xue
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Nat Med 18:100-10. 2012
    ..EPO) mRNA and protein expression by targeting stromal and perivascular cells that express PDGF receptor-β (PDGFR-β)...
  27. pmc Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein
    Yuri Fukumoto
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    J Biol Chem 286:43537-48. 2011
    ..These results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac...
  28. pmc PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia
    Jie Shen
    Department of Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    J Cereb Blood Flow Metab 32:353-67. 2012
    ..We investigated the role of PDGFR-β in tissue responses and functional recovery after photothrombolic middle cerebral artery occlusion (MCAO)...
  29. pmc p19Arf represses platelet-derived growth factor receptor β by transcriptional and posttranscriptional mechanisms
    Ryan C Widau
    Department of Pediatrics, Section of Hematology Oncology and Stem Cell Transplantation, University of Chicago, Chicago, Illinois, USA
    Mol Cell Biol 32:4270-82. 2012
    ..p19(Arf) plays an essential role in blocking signals stemming from platelet-derived growth factor receptor β (Pdgfrβ) during eye development, but the underlying mechanisms have not been clear...
  30. pmc Cognitive and socio-emotional deficits in platelet-derived growth factor receptor-β gene knockout mice
    Phuong Thi Hong Nguyen
    System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    PLoS ONE 6:e18004. 2011
    Platelet-derived growth factor (PDGF) is a potent mitogen. Extensive in vivo studies of PDGF and its receptor (PDGFR) genes have reported that PDGF plays an important role in embryogenesis and development of the central nervous system (..
  31. ncbi Mouse brains deficient in neuronal PDGF receptor-beta develop normally but are vulnerable to injury
    Yoko Ishii
    Department of Pathology, Faculty of Medicine, University of Toyama, Toyama, Japan
    J Neurochem 98:588-600. 2006
    ..Here, we developed novel mutant mice in which the gene encoding the beta subunit of PDGFR (PDGFR-beta) was genetically deleted in CNS neurons to elucidate the role of PDGFR-beta, particularly in the post-..
  32. ncbi Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages
    Bent Brachvogel
    Department of Cell and Matrix Biology, MCRI, 3052 Parkville Victoria, Australia
    Development 132:2657-68. 2005
    ..Hence, Anxa5 expression in perivascular cells from mouse defines a novel population of cells with a distinct developmental potential...
  33. ncbi Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation
    Alagarsamy Lakku Reddi
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:29336-47. 2007
    ..Cbl as an E3 ubiquitin ligase for ubiquitinylation and degradation of platelet-derived growth factor receptor (PDGFR) alpha and PDGFRbeta...
  34. ncbi Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly
    Shane S Foo
    Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
    Cell 124:161-73. 2006
    ..Our results indicate that the role of ephrin-B2 and EphB receptors in these processes involves Crk-p130(CAS) signaling and suggest that ephrin-B2 has some cell-cell-contact-independent functions...
  35. ncbi Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
    Min Hee Choi
    Division of Molecular Life Sciences and the Center for Cell Signaling Research, Ewha Womans University, Seoul 120 750, Korea
    Nature 435:347-53. 2005
    ..Prx II deficiency results in increased production of H2O2, enhanced activation of PDGF receptor (PDGFR) and phospholipase Cgamma1, and subsequently increased cell proliferation and migration in response to PDGF...
  36. ncbi Mesenchymal cells are required for functional development of thymic epithelial cells
    Manami Itoi
    Department of Immunology and Microbiology, Meiji University of Oriental Medicine, Hiyoshi cho, Nantan, Kyoto 629 0392, Japan
    Int Immunol 19:953-64. 2007
    ..In addition, our data suggest that mesenchymal cells are required to create the thymic microenvironment and to maintain epithelial architecture and function...
  37. ncbi Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells
    Brent Wagner
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Am Soc Nephrol 18:2903-11. 2007
    Mice deficient in either platelet-derived growth factor (PDGF) B chain or PDGF receptor (PDGFR) beta lack mesangial cells...
  38. pmc Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma
    Shioto Suzuki
    Ludwig Institute for Cancer Research, Uppsala Branch, Uppsala, Sweden
    BMC Cancer 7:224. 2007
    Platelet-derived growth factor (PDGF)-BB and PDGF receptor (PDGFR)-beta are mainly expressed in the developing vasculature, where PDGF-BB is produced by endothelial cells and PDGFR-beta is expressed by mural cells, including pericytes...
  39. doi Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein
    Vivian Y H Hook
    Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 283:7745-53. 2008
    ....
  40. pmc Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
    Marie Jeansson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    J Clin Invest 121:2278-89. 2011
    ..These findings redefine our understanding of the biological roles of angiopoietin-1: it is dispensable in quiescent vessels but has a powerful ability to modulate the vascular response after injury...
  41. doi The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress
    Tae Sun Kim
    Department of Molecular Neurobiology, Graduate School of Medical Sciences, Nagoya City University, Nagoya, 467 8601, Japan
    Dis Model Mech 3:752-62. 2010
    ..which in turn promotes survival of neurons by inducing expression of platelet-derived growth factor receptor β (PDGFRB)...
  42. pmc Stimulation of platelet-derived growth factor receptor beta (PDGFRbeta) activates ADAM17 and promotes metalloproteinase-dependent cross-talk between the PDGFRbeta and epidermal growth factor receptor (EGFR) signaling pathways
    Karen Mendelson
    Arthritis and Tissue Degeneration Program, The Hospital for Special Surgery, New York, New York 10021, USA
    J Biol Chem 285:25024-32. 2010
    ..This study identifies the principal sheddase for the PDGFRbeta and provides new insights into the mechanism of PDGFRbeta-dependent signal transduction and cross-talk with the EGFR...
  43. pmc Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress
    Vishnu Chintalgattu
    Department of Cardiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Clin Invest 120:472-84. 2010
    ..In mice in which Pdgfrb was knocked out in the heart in development or in adulthood, exposure to load-induced stress resulted in cardiac ..
  44. doi Strong oligomerization behavior of PDGFbeta receptor transmembrane domain and its regulation by the juxtamembrane regions
    Joanne Oates
    Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK
    Biochim Biophys Acta 1798:605-15. 2010
    ....
  45. pmc Apoptosis regulator through modulating IAP expression (ARIA) controls the PI3K/Akt pathway in endothelial and endothelial progenitor cells
    Masahiro Koide
    Department of Cardiovascular Medicine, Kyoto Prefectural University School of Medicine, Kyoto 602 8566, Japan
    Proc Natl Acad Sci U S A 108:9472-7. 2011
    ..These functions of ARIA might offer a unique therapeutic potential...
  46. pmc Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli
    Rui Benedito
    Centro Interdisciplinar de Investigação em Sanidade Animal, Faculdade de Medicina Veterinaria, Technical University of Lisbon, Lisboa, Portugal
    BMC Dev Biol 8:117. 2008
    ..Dll4 null embryos die very early in development with severely reduced arterial calibre and lumen and loss of arterial cell identity...
  47. doi Platelet-derived growth factor receptor beta-subtype regulates proliferation and migration of gonocytes
    Sabrina Basciani
    Department of Medical Physiopathology, Sapienza University, Policlinico Umberto I, 00161 Rome, Italy
    Endocrinology 149:6226-35. 2008
    ..0 (E18) and up to P5, the gonocytes express platelet-derived growth factor (PDGF) receptor beta-subtype (PDGFR-beta) and that during the same time period, the Sertoli cells express PDGF-B and PDGF-D, both ligands for PDGFR-..
  48. doi Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut
    M Kurahashi
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya, Japan
    Neurogastroenterol Motil 20:521-31. 2008
    ..The selective PDGF receptor inhibitor AG1295 suppressed the differentiation of LMC in gut explants. We conclude that PDGF signals play critical roles in the differentiation of LMC in mouse embryonic gut...
  49. doi A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  50. pmc A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human
    A M Buchberg
    Mammalian Genetics Laboratory, NCI Frederick Cancer Research Facility, Maryland 21701
    Genetics 122:153-61. 1989
    ..and the known linkage homologies that exist between murine chromosome 11 and human chromosomes (Mpo, Ngfr, Pdgfr and Fms). Two of the latter genes, Mpo and Ngfr, mapped to mouse chromosome 11...
  51. ncbi The PDGF receptor phosphorylates Tyr 138 in the c-Src SH3 domain in vivo reducing peptide ligand binding
    M A Broome
    Molecular Biology and Virology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Oncogene 14:17-34. 1997
    ..However, Tyr 138 phosphorylation was found to diminish SH3 domain peptide ligand binding ability in vitro...
  52. ncbi p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y
    Anders Hackzell
    Department of Cell Biology, Institute of Anatomy and Cell Biology, Goteborg University, Box 420, SE 405 30 Gothenburg, Sweden
    J Biol Chem 277:39769-76. 2002
    ..Our results indicate that serum stimulation induces c-Myc and p73alpha, leading to the down-regulation of PDGF beta-receptor expression by repressing its transcription...
  53. ncbi Sp1 is a key regulator of the PDGF beta-receptor transcription
    C Molander
    Institute of Anatomy and Cell Biology, Goteborg University, Gothenburg, Sweden
    Mol Biol Rep 28:223-33. 2001
    ..However, we could not find any effect of Sp1 in the c-Myc-mediated repression on the PFDGF beta-receptor promoter, since the deletion of SpI binding sites could not attenuate the repression by c-Myc on the promoter activity...
  54. ncbi PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor
    E Bergsten
    Ludwig Institute for Cancer Research, Stockholm Branch, PO Box 240, S 171 77 Stockholm, Sweden
    Nat Cell Biol 3:512-6. 2001
    ..The PDGF alpha-receptor (PDGFR-alpha) binds to all three PDGF chains, whereas the beta-receptor (PDGFR-beta) binds only to PDGF-B...
  55. ncbi PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis
    H Riedel
    Department of Biological Sciences, Wayne State University, Detroit, Michigan, MI 48202, USA
    Oncogene 19:39-50. 2000
    ..We have mapped Y740 as a site of PDGFR beta that is involved in the association with PSM...
  56. ncbi The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic mice
    K A Ritchie
    Medical Research Service, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Leukemia 13:1790-803. 1999
    ..This murine model of CMML parallels a myeloproliferative syndrome in humans and implicates the Tel-PDGFRbeta fusion protein in its pathogenesis...
  57. ncbi A multipoint genetic linkage map of mouse chromosome 18
    K R Johnson
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 13:1143-9. 1992
    ..3-Tpi-10-11.8-(Egr-1, Hmg17-rs9)-2.1-Fgfa-2.2-Grl-1-10.1-(Cdx-1, Csfmr, Pdgfrb, Pdea, Rps14)-2.1-Adrb-2-22.9-Mbp...
  58. ncbi Cbl-mediated negative regulation of platelet-derived growth factor receptor-dependent cell proliferation. A critical role for Cbl tyrosine kinase-binding domain
    S Miyake
    Lymphocyte Biology Section, Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 274:16619-28. 1999
    ..compromised the PDGF-inducible tyrosine phosphorylation of Cbl although this mutant could still associate with the PDGFR. More importantly, the G306E mutation abrogated the ability of Cbl to enhance the ligand-induced ubiquitination ..
  59. ncbi Nuclear factor Y controls the basal transcription activity of the mouse platelet-derived-growth-factor beta-receptor gene
    A Ishisaki
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Eur J Biochem 246:142-6. 1997
    ..The binding proteins were affinity purified and identified as the NF-Y transcription factor by western blotting. Our results indicate that NF-Y controls the basal transcription activity of the mouse PDGF beta-receptor gene...
  60. ncbi Developmental distribution of platelet-derived growth factor in the mouse central nervous system
    J B Hutchins
    Department of Anatomy, University of Mississippi Medical Center, Jackson 39216 4505
    Brain Res Dev Brain Res 67:121-35. 1992
    ..By E15, both PDGF isoform and PDGF receptor beta subunit immunoreactivity have declined to near-background levels in the sensory ganglia, while in the spinal cord and developing forebrain, levels of all PDGF-related proteins remain high...
  61. ncbi Isolation and characterization of the platelet-derived growth factor beta receptor promoter
    E Shinbrot
    Daiichi Research Center, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Dev Dyn 208:211-9. 1997
    ..The further analysis of this promoter will help elucidate the transcriptional regulation of expression of the PDGFbeta r, and provide a useful tool for directing expression of heterologous genes...
  62. ncbi SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
    G S Feng
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Science 259:1607-11. 1993
    ..The Syp gene is widely expressed throughout embryonic mouse development and in adult tissues. Thus, Syp may function in mammalian embryonic development and as a common target of both receptor and nonreceptor tyrosine kinases...
  63. ncbi Human brain-specific L-proline transporter: molecular cloning, functional expression, and chromosomal localization of the gene in human and mouse genomes
    S Shafqat
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Pharmacol 48:219-29. 1995
    ..These findings warrant the consideration of a synaptic regulatory role for this transporter and its presumed natural substrate, L-proline, in the mammalian central nervous system...
  64. ncbi Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation
    M C Bidwell
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 136:5189-201. 1995
    ....
  65. pmc Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins
    Joseph H McCarty
    Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell Biol 22:7667-77. 2002
    ..These data suggest a novel role for alphav integrins in the association between cerebral microvessels and central nervous system parenchymal cells...
  66. pmc Additive effects of PDGF receptor beta signaling pathways in vascular smooth muscle cell development
    Michelle D Tallquist
    Program in Developmental Biology and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 1:E52. 2003
    ..The combined in vivo and biochemical data suggest that the summation of pathways associated with the PDGFRbeta signal transduction determines the expansion of developing v/p cells...
  67. ncbi Forced expression of platelet-derived growth factor B in the mouse cerebellar primordium changes cell migration during midline fusion and causes cerebellar ectopia
    Johanna Andrae
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, SE 751 85 Uppsala, Sweden
    Mol Cell Neurosci 26:308-21. 2004
    ..b>PDGFR-alpha- and laminin alpha1-positive meningeal cells migrated inwards, attracted by the ectopic transgene expression ..
  68. ncbi S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR)
    Linnea M Baudhuin
    Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 18:341-3. 2004
    ..In addition, S1P-stimulated activation of Akt, but not ERK, was blocked by a PDGF receptor (PDGFR)-specific inhibitor, AG1296, suggesting a S1P3-mediated specific crosstalk between the Akt signaling pathways of ..
  69. ncbi Protocadherin 12 (VE-cadherin 2) is expressed in endothelial, trophoblast, and mesangial cells
    Christine Rampon
    Laboratoire Développement et Vieillissement de l Endothélium CEA Inserm EMI 0219, Grenoble, France
    Exp Cell Res 302:48-60. 2005
    ..We conclude that PCDH12 has a unique expression pattern and that its deficiency does not lead to conspicuous abnormalities. Moreover, PCDH12 is the first specific marker for both glycogen-rich trophoblasts and mesangial cells...
  70. ncbi The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
    Xiaowei Lu
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nature 432:179-86. 2004
    ..Netrin-1 causes endothelial filopodial retraction, but only when UNC5B is present. Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system...
  71. pmc Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase
    Camilla Persson
    Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, S 751 24 Uppsala, Sweden
    Mol Cell Biol 24:2190-201. 2004
    ..In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors...
  72. ncbi Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
    Tatiana V Petrova
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Nat Med 10:974-81. 2004
    ..Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD...
  73. pmc Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor
    Rina Plattner
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 24:2573-83. 2004
    ..signals such as the platelet-derived growth factor (PDGF) and functions downstream of the PDGF-beta receptor (PDGFR) to mediate biological processes such as membrane ruffling, mitogenesis, and chemotaxis...
  74. ncbi Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis
    Christian Rupp
    Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Cancer Immun 6:10. 2006
    ..In future studies, the search for intrinsic or extrinsic signals contributing to endosialin induction in cancer stroma will be of interest...
  75. ncbi The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor
    Jaclyn S Long
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Prostaglandins Other Lipid Mediat 80:74-80. 2006
    ..These findings resolve an important issue regarding the functional role of the S1P(1) receptor in regulating MEF migration and suggest an important role within the context of PDGFbeta receptor-S1P(1) receptor complex signaling...
  76. ncbi Roles of platelet-derived growth factor in the developing and mature nervous systems
    C F Valenzuela
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262, USA
    Brain Res Brain Res Rev 24:77-89. 1997
    ..We also discuss the modulatory effects of PDGF on synaptic transmission, its role in neoplastic and non-neoplastic conditions of the central nervous system, and the neuroprotective effects of this growth factor...
  77. ncbi Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro
    Peetra U Magnusson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
    Arterioscler Thromb Vasc Biol 27:2142-9. 2007
    ..This study describes the consequences of a constitutively activating mutation of the PDGFR-beta (Pdgfrb(D849V)) introduced into embryonic stem cells with respect to vasculogenesis/angiogenesis in vitro and in vivo.
  78. ncbi The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins
    M Dean Chamberlain
    Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Biol Chem 279:48607-14. 2004
    ..or degradation of activated receptor tyrosine kinases such as the platelet-derived growth factor receptor (PDGFR)...
  79. ncbi Contractile activity of skeletal musculature involved in breathing is essential for normal lung cell differentiation, as revealed in Myf5-/-:MyoD-/- embryos
    Mohammad Reza Inanlou
    Dalhousie University, Faculty of Medicine, Department of Anatomy and Neurobiology, Halifax, Nova Scotia, Canada
    Dev Dyn 233:772-82. 2005
    ..Together, our findings suggest that pulmonary distension due to fetal breathing-like movements plays an important role not only in lung growth but also in lung cell differentiation...
  80. ncbi Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor
    Yuji Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:23216-22. 2002
    ..Because PDGF-mediated ERK activation is enhanced in Chinese hamster ovary cells that overexpress Gab1, Gab1 serves as an important link between PKC and ERK activation by PDGFbeta receptors in VSMC...
  81. ncbi Photoreceptor-specific overexpression of platelet-derived growth factor induces proliferation of endothelial cells, pericytes, and glial cells and aberrant vascular development: an ultrastructural and immunocytochemical study
    Stanley A Vinores
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287 9289, USA
    Brain Res Dev Brain Res 140:169-83. 2003
    ..Pericytes and glial cells are usually found in clusters and are not associated with the abnormal vessels. The lack of this association may account for the failure to form a mature vasculature...
  82. ncbi Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury
    Sekiko Taneda
    Department of Pathology, University of Washington, Seattle, Washington, USA
    J Am Soc Nephrol 14:2544-55. 2003
    ..These observations suggest that PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF-Rbeta in both human obstructive nephropathy and the corresponding murine model of UUO...
  83. ncbi Dynamic recruitment of NF-Y and histone acetyltransferases on cell-cycle promoters
    Giuseppina Caretti
    Dipartimento di Biologia Animale, Università di Modena e Reggio, Via Campi 213 D, 41100 Modena, Italy
    J Biol Chem 278:30435-40. 2003
    ..These data indicate that following the release of E2Fs/HDACs, a hierarchy of PCAF-NF-Y-p300 interactions and H3-H4 acetylations are required for activation of cell-cycle promoters...
  84. ncbi Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology
    Shinsuke Nakata
    Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine Faculty of Medicine, Suita, Osaka, Japan
    J Biol Chem 282:37815-25. 2007
    ..Thus, afadin plays a critical role in the proper regulation of the PDGF-induced activation of PDGF receptor and signaling by Ras-ERK. This effect, which is mediated by SHP-2, impacts cellular morphology...
  85. pmc Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGFbeta receptor
    Jennifer B Ptacek
    Department of Genetics and Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:11945-50. 2007
    ..Our results also suggested that excluding hydrophilic residues from small TM proteins and peptides is a strategy to increase the specificity of heteromeric TM helix-helix interactions...
  86. pmc Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice
    Koichi Kozaki
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Pathol 161:1395-407. 2002
    ..Thus, elimination of PDGF-B from circulating cells or blockade of PDGF receptors does not appear sufficient to prevent smooth muscle accumulation in advanced lesions of atherosclerosis...
  87. doi Involvement of platelet-derived growth factor receptor-beta in maintenance of mesenchyme and sensory epithelium of the neonatal mouse inner ear
    Hisamitsu Hayashi
    Department of Otolaryngology, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu shi, Gifu 501 1194, Japan
    Hear Res 245:73-81. 2008
    Platelet-derived growth factor receptor (PDGFR) signaling has been demonstrated to play a pivotal role in early embryonic development...
  88. ncbi Platelet-derived growth factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-beta in murine nucleus tractus solitarius
    Yoshiaki Ohi
    Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    Brain Res 1159:77-85. 2007
    Although platelet-derived growth factor (PDGF)-BB activates PDGF receptor-beta (PDGFR-beta) and, in turn, inhibits the glutamate N-methyl-D-aspartate (NMDA) receptor function, whether PDGF-BB modulates the CNS function mediated by ..
  89. pmc A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles
    Kristen Pollizzi
    Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 18:2378-87. 2009
    ..Tsc2-del3 mice also serve as a model for hypomorphic TSC2 missense mutations reported in TSC patients...
  90. pmc Cooperation between the PDGF receptors in cardiac neural crest cell migration
    Alicia M Richarte
    Department of Molecular Biology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Dev Biol 306:785-96. 2007
    ..Previously, we had shown that disruption of the platelet-derived growth factor receptor (PDGFR) alpha in NCCs resulted in defects in craniofacial and aortic arch development, the latter with variable ..
  91. pmc Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells
    Bin Zheng
    Department of Biochemistry and Molecular Biology, Hebei Medical University, Zhongshan East Road, Shijiazhuang 050017, China
    J Biol Chem 284:22773-85. 2009
    ..investigated the mechanisms whereby Klf4 mediates the growth inhibitory effects in VSMCs through RAR alpha and PDGFR beta. We demonstrated that Klf4 directly binds to the 5' regulatory region of RAR alpha, down-regulates RAR alpha ..
  92. pmc Chimera analysis supports a predominant role of PDGFRbeta in promoting smooth-muscle cell chemotaxis after arterial injury
    Bernard S Buetow
    Department of Pathology, University of Washington, Seattle, WA 98195 7470, USA
    Am J Pathol 163:979-84. 2003
    ..We conclude that the most significant direct role of PDGFRbeta is to mediate responses that involve cell migration rather than proliferation...
  93. ncbi Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution
    R J Oakey
    Department of Medicine, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710
    Genomics 10:338-44. 1991
    ..We have identified a region that may have been translocated during evolution and suggest that the human genomic organization of adrenergic receptors more closely resembles that of a putative primordial ancestor...
  94. pmc The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
    Koichi Hamada
    Department of Molecular Biology, Department of Microbiology, Department of Gastroenterology, Akita University School of Medicine, Akita 010 8543, Japan
    Genes Dev 19:2054-65. 2005
    ..Pten is thus indispensable for normal cardiovascular morphogenesis and post-natal angiogenesis, including tumor angiogenesis...
  95. ncbi Platelet-derived growth factor D induces cardiac fibrosis and proliferation of vascular smooth muscle cells in heart-specific transgenic mice
    Annica Pontén
    Ludwig Institute for Cancer Research, S 17177 Stockholm, Sweden
    Circ Res 97:1036-45. 2005
    ..PDGF)-D is a member of the PDGF/vascular endothelial growth factor family that activates PDGF receptor beta (PDGFR-beta)...
  96. ncbi Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiation
    Yan Wang
    Department of Biochemistry and Molecular and Cellular Biology, Georgetown University Medical Center, Washington, D C 20057, USA
    Endocrinology 148:2233-50. 2007
    We have shown previously that neonatal testicular gonocytes express platelet-derived growth factor receptors (PDGFR) alpha and beta...
  97. ncbi Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors. Involvement of sphingosine 1-phosphate in PDGF but not EGF signaling
    C S Rani
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, D C 20007, USA
    J Biol Chem 272:10777-83. 1997
    ..Thus, regulation of sphingosine kinase activity defines divergence in signal transduction pathways of PDGF and EGF receptors leading to mitogen-activated protein kinase activation...

Research Grants7

  1. MEDIATORS OF BLOOD-RETINAL BARRIER BREAKDOWN
    STANLEY VINORES; Fiscal Year: 2002
    ....
  2. Proteomics/Genomics of Opiate Analgesia and Addiction
    Vivian Hook; Fiscal Year: 2004
    ..Elucidation of distinct pathways will be significant, since it could allow future design of opiate drug regimens that provide effective analgesia, without the tolerance and dependence of addiction. ..
  3. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  4. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  5. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2008
    ..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..
  6. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  7. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings will enhance our knowledge of the complexity of the endogenous opioid system. ..