Pdgfb

Summary

Gene Symbol: Pdgfb
Description: platelet derived growth factor, B polypeptide
Alias: PDGF-B, Sis, platelet-derived growth factor subunit B, PDGF subunit B, PDGF-2, c-sis, platelet-derived growth factor B chain, platelet-derived growth factor beta polypeptide, proto-oncogene c-Sis
Species: mouse

Top Publications

  1. pmc Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1
    Kakali Dhar
    Cancer Research Unit, VA Medical Center, 4801 Linwood Blvd, Kansas City, Missouri 64128, USA
    Mol Cancer 9:209. 2010
  2. pmc Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Biol Chem 285:21615-24. 2010
  3. pmc Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
    Marie Jeansson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    J Clin Invest 121:2278-89. 2011
  4. ncbi Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
    P Leveen
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Genes Dev 8:1875-87. 1994
  5. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
  6. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
  7. ncbi PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta
    R Ohlsson
    Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, Uppsala, S 752 36, Sweden
    Dev Biol 212:124-36. 1999
  8. ncbi Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells
    L Uhrbom
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Int J Cancer 85:398-406. 2000
  9. pmc Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment
    M S Seo
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Am J Pathol 157:995-1005. 2000
  10. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001

Research Grants

  1. GLOMERULAR LAMININS: STRUCTURE AND FUNCTION
    Christine Abrass; Fiscal Year: 2003
  2. Molecular Mechanisms of Mesangial Sclerosis
    Christine Abrass; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications119 found, 100 shown here

  1. pmc Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1
    Kakali Dhar
    Cancer Research Unit, VA Medical Center, 4801 Linwood Blvd, Kansas City, Missouri 64128, USA
    Mol Cancer 9:209. 2010
    ..This study focuses on the role of human tumor cells in governing the differentiation of mouse mesenchymal stem cells (MSCs) to pericytes and their recruitment in the tumor angiogenesis process...
  2. pmc Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1
    Fuwang Peng
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    J Biol Chem 285:21615-24. 2010
    ..Chromatin immunoprecipitation assays demonstrated the binding of Egr-1, but not Egr-3, to the Arc promoter. These findings for the first time, thus, suggest an additional role of PDGF, that of induction of Arc...
  3. pmc Angiopoietin-1 is essential in mouse vasculature during development and in response to injury
    Marie Jeansson
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    J Clin Invest 121:2278-89. 2011
    ..These findings redefine our understanding of the biological roles of angiopoietin-1: it is dispensable in quiescent vessels but has a powerful ability to modulate the vascular response after injury...
  4. ncbi Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities
    P Leveen
    Department of Medical Biochemistry, University of Goteborg, Sweden
    Genes Dev 8:1875-87. 1994
    ..We show here that mice deficient for PDGF B die perinatally and display several anatomical and histological abnormalities...
  5. ncbi Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
    P Lindahl
    Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S 413 90 Göteborg, Sweden
    Science 277:242-5. 1997
    ..Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts...
  6. ncbi Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 126:3047-55. 1999
    ..Subsequent angiogenic sprouting and vessel enlargement involves PDGF-B-dependent vSMC/PC progenitor co-migration and proliferation, and/or PDGF-B-independent new induction of vSMC/PC, depending on tissue context...
  7. ncbi PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta
    R Ohlsson
    Department of Animal Development and Genetics, Uppsala University, Norbyvagen 18A, Uppsala, S 752 36, Sweden
    Dev Biol 212:124-36. 1999
    b>PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene...
  8. ncbi Dependence of autocrine growth factor stimulation in platelet-derived growth factor-B-induced mouse brain tumor cells
    L Uhrbom
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Int J Cancer 85:398-406. 2000
    ..brain tumors of neuroepithelial origin were induced by injecting a murine retrovirus containing the human PDGF B-chain gene into the brains of neonatal mice...
  9. pmc Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment
    M S Seo
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Am J Pathol 157:995-1005. 2000
    ..They also provide a new model of traction retinal detachment that can be used to investigate new treatments for patients with proliferative retinopathies...
  10. pmc Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    M Hellstrom
    Department of Medical Biochemistry, Goteborg University, SE 405 30 Goteborg, Sweden
    J Cell Biol 153:543-53. 2001
    ....
  11. ncbi Retina-specific expression of PDGF-B versus PDGF-A: vascular versus nonvascular proliferative retinopathy
    Keisuke Mori
    Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 9277, USA
    Invest Ophthalmol Vis Sci 43:2001-6. 2002
    ..This study was undertaken to determine whether higher levels of endogenously produced PDGF-A in the retinas of mice result in retinal detachment...
  12. pmc Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy
    Maria Enge
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    EMBO J 21:4307-16. 2002
    ..Our data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice, implying that pericyte loss may also be a causal pathogenic event in human diabetic retinopathy...
  13. pmc Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
    Per Lindblom
    Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
    Genes Dev 17:1835-40. 2003
    ..We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice...
  14. ncbi Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities
    Mattias Bjarnegard
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 131:1847-57. 2004
    Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development, but the relative importance of different cellular sources of PDGFB has not been established...
  15. pmc Pericytes limit tumor cell metastasis
    Xiaojie Xian
    Stem Cell Center, Lund University, Lund, Sweden
    J Clin Invest 116:642-51. 2006
    ..the metastatic potential of solid tumors, we studied beta cell tumorigenesis in primary pericyte-deficient Pdgfb(ret/ret) mice...
  16. pmc Tumor progression and oncogene addiction in a PDGF-B-induced model of gliomagenesis
    Filippo Calzolari
    National Institute for Cancer Research IST, IRCCS, Genoa, Italy
    Neoplasia 10:1373-82, following 1382. 2008
    ....
  17. doi PDGF-B induces a homogeneous class of oligodendrogliomas from embryonic neural progenitors
    Irene Appolloni
    Department of Genic Transfer, National Institute for Cancer Research IST, IRCCS, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Int J Cancer 124:2251-9. 2009
    ..However only PDGF-B-overexpressing cells are tumorigenic, indicating that paracrine signaling from the tumor is unable to transform bystander cells...
  18. doi Enlarged lateral ventricles and aberrant behavior in mice overexpressing PDGF-B in embryonic neural stem cells
    Mia Niklasson
    Department of Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden
    Exp Cell Res 316:2779-89. 2010
    ..Adult transgenic males, however, showed behavioral aberrations and locomotor dysfunction. Thus, a tightly regulated expression of PDGF during embryogenesis is required for normal brain development and function in mice...
  19. doi Pericytes regulate the blood-brain barrier
    Annika Armulik
    Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Karolinska Institute, Scheeles vag 2, SE 171 77 Stockholm, Sweden
    Nature 468:557-61. 2010
    ..Our results indicate a novel and critical role for pericytes in the integration of endothelial and astrocyte functions at the neurovascular unit, and in the regulation of the BBB...
  20. pmc Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity
    Summer M Raines
    Department of Biochemistry, Univ of Wisconsin Madison, USA
    Am J Physiol Endocrinol Metab 301:E517-26. 2011
    ..To the best of our knowledge, this is the first study to connect PDGF-B-induced changes in hepatic sinusoidal transport to changes in insulin action, demonstrating a link between PDGF-B signaling and insulin sensitivity...
  21. doi Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice
    Annika Keller
    Institute for Neuropathology, University Hospital Zurich, Zurich, Switzerland
    Nat Genet 45:1077-82. 2013
    ..We also show that mice carrying hypomorphic Pdgfb alleles develop brain calcifications that show age-related expansion...
  22. ncbi Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
    P Lindahl
    Department of Medical Biochemistry, Goteborg University, PO Box 440, SE 405 30 Goteborg, Sweden
    Development 125:3313-22. 1998
    ....
  23. ncbi Oligodendrocyte precursor hypercellularity and abnormal retina development in mice overexpressing PDGF-B in myelinating tracts
    Karin Forsberg-Nilsson
    Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala, Sweden
    Glia 41:276-89. 2003
    ..Our observations strengthen the notion that PDGF is an important effector molecule in postnatal CNS development...
  24. ncbi Expression and role of PDGF-BB and PDGFR-beta during testis morphogenesis in the mouse embryo
    Antonella Puglianiello
    Department of Public Health and Cell Biology, Section Histology and Embryology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Cell Sci 117:1151-60. 2004
    ..The present findings support the hypothesis that the PDGF/PDGFR system plays a key role in testis morphogenesis in the mouse embryo...
  25. ncbi Liver fibrosis induced by hepatic overexpression of PDGF-B in transgenic mice
    Piotr Czochra
    Department of Medicine, Johannes Gutenberg University, Mainz, Germany
    J Hepatol 45:419-28. 2006
    ..In hepatic fibrogenesis, stellate cells are activated leading to production and deposition of extracellular matrix. To clarify the role of PDGF-B in liver fibrogenesis, we overexpressed PDGF-B in the liver of transgenic mice...
  26. pmc Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development
    Alexandra Abramsson
    Department of Medical Biochemistry and Biophysics, Division of Matrix Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Genes Dev 21:316-31. 2007
    ....
  27. pmc Slug is a direct Notch target required for initiation of cardiac cushion cellularization
    Kyle Niessen
    Department of Medical Biophysics, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada
    J Cell Biol 182:315-25. 2008
    ..Collectively, our data suggest that combined expression of Slug and Snail is required for EMT in cardiac cushion morphogenesis...
  28. pmc Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation
    Jonas Fuxe
    Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Am J Pathol 178:2897-909. 2011
    ..The findings also show that the antileakage action of Ang1 requires PDGF-dependent actions of pericytes in maintaining endothelial stability...
  29. pmc PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
    Hui Xie
    1 Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA 2 Institute of Endocrinology and Metabolism, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Nat Med 20:1270-8. 2014
    ..Thus, pharmacotherapies that increase PDGF-BB secretion from preosteoclasts offer a new therapeutic target for treating osteoporosis by promoting angiogenesis and thus bone formation. ..
  30. ncbi Characterization of the mouse PDGF A-chain gene. Evolutionary conservation of gene structure, nucleotide sequence and alternative splicing
    F Rorsman
    Department of Pathology, University Hospital, Uppsala, Sweden
    Growth Factors 6:303-13. 1992
    ..The untranslated sequences show a high degree of nucleotide sequence identity and several conserved consensus binding sites for transcription factors are identified within the 5' untranslated as well as in the 5' flanking region...
  31. ncbi Selective expression of PDGF A and its receptor during early mouse embryogenesis
    M Mercola
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts
    Dev Biol 138:114-22. 1990
    Murine homologs of the PDGF A, PDGF B, and PDGF receptor alpha subunit genes were cloned...
  32. pmc Deletion of Alu sequences in the fifth c-sis intron in individuals with meningiomas
    M Smidt
    Department of Medicine, Washington University, St Louis, Missouri 63110
    J Clin Invest 86:1151-7. 1990
    An abnormality in the c-sis protooncogene was identified in leukocyte DNA from members of a family predisposed to the development of meningioma, and was found to be associated with the development of the tumor in those individuals...
  33. pmc Murine Ly-6 multigene family is located on chromosome 15
    K P LeClair
    Proc Natl Acad Sci U S A 84:1638-42. 1987
    ..polymorphism probe), 3 map units from ins-1, (insulin-related gene), and 4 map units from the protooncogene c-sis. The possible involvement of the Ly-6 lymphocyte activation and differentiation antigen genes in chromosome 15-..
  34. ncbi Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor
    B H Cochran
    Science 226:1080-2. 1984
    ..Expression of the authentic c-fos gene is induced by PDGF and superinduced by the combination of PDGF and cycloheximide...
  35. ncbi Effect of platelet-derived growth factor on phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like cells
    O Kozawa
    Department of Biochemistry, Institute for Developmental Research, Aichi, Japan
    Endocrinology 136:4473-8. 1995
    ....
  36. ncbi Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development
    I MacNeil
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 151:6913-23. 1993
    ..Our results suggest that TSA-1 may play a role during positive selection and the transition from CD4+CD8+ thymocytes to the mature CD4+CD8- and CD4-CD8+ subsets...
  37. ncbi Human homology and candidate genes for the Dominant megacolon locus, a mouse model of Hirschsprung disease
    V Pingault
    INSERM U91, Hopital Henri Mondor, Creteil, France
    Genomics 39:86-9. 1997
    ..Three genes (Smstr3, Lgals1, and Pdgfb) are possible Dom candidates, as they do not recombine with the Dom mutation in a 252 Dom/+ animal backcross.
  38. ncbi PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
    X Li
    Ludwig Institute for Cancer Research, Stockholm, Sweden
    Nat Cell Biol 2:302-9. 2000
    ....
  39. pmc Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad
    Jennifer Brennan
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Genes Dev 17:800-10. 2003
    ..This work identifies PDGF signaling through the alpha receptor as an important event downstream of Sry in testis organogenesis and Leydig cell differentiation...
  40. pmc Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans
    Lijun Xia
    Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 N E 13th St, Oklahoma City, OK 73104, USA
    J Cell Biol 164:451-9. 2004
    ..These data reveal an unexpected requirement for core 1-derived O-glycans during angiogenesis...
  41. ncbi PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development
    Aaron D Gitler
    Cardiovascular Division, Department of Medicine, University of Pennsylvania Health System, 954 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Dev Cell 7:107-16. 2004
    ..Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis...
  42. pmc The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
    Koichi Hamada
    Department of Molecular Biology, Department of Microbiology, Department of Gastroenterology, Akita University School of Medicine, Akita 010 8543, Japan
    Genes Dev 19:2054-65. 2005
    ..Pten is thus indispensable for normal cardiovascular morphogenesis and post-natal angiogenesis, including tumor angiogenesis...
  43. ncbi Neurofibromin is a novel regulator of RAS-induced signals in primary vascular smooth muscle cells
    Fang Li
    Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, 1044 W Walnut Street, Indianapolis, IN 46202, USA
    Hum Mol Genet 15:1921-30. 2006
    ....
  44. pmc Inhibition of platelet-derived growth factor B signaling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
    Nobuo Jo
    Eyetech Research Center, 35 Hartwell Ave, Lexington, MA 02421, USA
    Am J Pathol 168:2036-53. 2006
    ..These findings provide insight into blood vessel growth factor dependency and validate a combination therapy strategy for enhancing the current treatments for ocular angiogenic disease...
  45. pmc Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor
    Kristina Talbert-Slagle
    Department of Genetics, P O Box 208034, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 83:9773-85. 2009
    ..We speculate that similar cellular proteins may exist but have been overlooked due to their small size and hydrophobicity...
  46. doi Platelet derived growth factor B and epithelial mesenchymal transition of peritoneal mesothelial cells
    Pranali Patel
    Department of Medicine, McMaster University, Division of Nephrology, St Joseph s Hospital, 50 Charlton Ave E, Hamilton, Ontario, Canada L8P4A6
    Matrix Biol 29:97-106. 2010
    ..The observed effects were similar in Smad3(-/-) and Smad3+/+ animals, suggesting that the PDGF-B effects were independent of TGFbeta or Smad signaling...
  47. doi Msx genes define a population of mural cell precursors required for head blood vessel maturation
    Miguel Lopes
    Institut Pasteur, Génétique Moléculaire de la Morphogenèse, CNRS URA 2578, Paris, France
    Development 138:3055-66. 2011
    ..Improper coverage by VSMCs secondarily leads to incomplete maturation of the endothelial layer. Our results demonstrate that both Msx1 and Msx2 are required for the recruitment of a population of neural crest-derived VSMCs...
  48. pmc Lysophosphatidic acid increases proximal tubule cell secretion of profibrotic cytokines PDGF-B and CTGF through LPA2- and Gαq-mediated Rho and αvβ6 integrin-dependent activation of TGF-β
    Hui Geng
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Am J Pathol 181:1236-49. 2012
    ..We suggest that LPA-initiated autocrine signaling is a potentially important mechanism that gives rise to paracrine profibrotic signaling in injured kidney tubule cells...
  49. doi LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling
    Aleksandar Kuzmanov
    Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland
    Mol Oncol 8:401-16. 2014
    ....
  50. pmc TGFβ and PDGF-B signaling blockade inhibits myofibroblast development from both bone marrow-derived and keratocyte-derived precursor cells in vivo
    Vivek Singh
    The Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA LV Prasad Eye Institute, HERF, Hyderabad, AP, India
    Exp Eye Res 121:35-40. 2014
    ..TGFβ and PDGF regulate corneal myofibroblast development from bone marrow-derived precursor cells and keratocyte/corneal fibroblast-derived precursor cells. ..
  51. pmc Tat 101-mediated enhancement of brain pericyte migration involves platelet-derived growth factor subunit B homodimer: implications for human immunodeficiency virus-associated neurocognitive disorders
    Fang Niu
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198
    J Neurosci 34:11812-25. 2014
    ..These findings thus implicate a novel role of PDGF-BB in the migration of pericytes, resulting in loss of pericyte coverage from the endothelium with a subsequent breach of the BBB. ..
  52. pmc Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice
    F S Lee
    Department of Genetics, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 92:2268-72. 1995
    ..This newly discovered Wnt family member was expressed in the embryo and mammary gland of virgin but not pregnant mice and represents a candidate collaborating oncogene of int-2/Fgf-3 in the mammary epithelium...
  53. doi Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    Tuomas Tammela
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and the Haartman Institute University of Helsinki, PO Box 63 Haartmaninkatu 8, 00014 Helsinki, Finland
    Nature 454:656-60. 2008
    ..Our results implicate VEGFR-3 as a regulator of vascular network formation. Targeting VEGFR-3 may provide additional efficacy for anti-angiogenic therapies, especially towards vessels that are resistant to VEGF or VEGFR-2 inhibitors...
  54. doi PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells
    Yuan Xue
    Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden
    Nat Med 18:100-10. 2011
    ....
  55. pmc PDGF mediates TGFβ-induced migration during development of the spinous process
    Ying Wang
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA
    Dev Biol 365:110-7. 2012
    ....
  56. doi Phenotypical differences in connective tissue cells emerging from microvascular pericytes in response to overexpression of PDGF-B and TGF-β1 in normal skin in vivo
    Alejandro Rodriguez
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    Am J Pathol 182:2132-46. 2013
    ..This study offers new insight into the effects of PDGF-B and TGF-β1 on the vasculature and connective tissue in vivo...
  57. ncbi Developmental distribution of platelet-derived growth factor in the mouse central nervous system
    J B Hutchins
    Department of Anatomy, University of Mississippi Medical Center, Jackson 39216 4505
    Brain Res Dev Brain Res 67:121-35. 1992
    ..By E15, both PDGF isoform and PDGF receptor beta subunit immunoreactivity have declined to near-background levels in the sensory ganglia, while in the spinal cord and developing forebrain, levels of all PDGF-related proteins remain high...
  58. ncbi An interspecific linkage map of mouse chromosome 15 positioned with respect to the centromere
    C I Brannan
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Maryland 21702
    Genomics 13:1075-81. 1992
    ....
  59. ncbi Gene order and genetic distance of 13 loci spanning murine chromosome 15
    H Hameister
    Abteilung Klinische Genetik, Universitat Ulm, Germany
    Genomics 14:417-22. 1992
    ..Despite the unequal distribution along chromosome 15 of G-versus R-bands, a comparison of distances determined by physical and genetic mapping does not indicate an overt difference in distance between both mapping techniques...
  60. ncbi Structure of the murine c-sis proto-oncogene (Sis, PDGFB) encoding the B chain of platelet-derived growth factor
    D T Bonthron
    Human Genetics Unit, Edinburgh University, Department of Medicine, Western General Hospital, Scotland
    Genomics 10:287-92. 1991
    The murine proto-oncogene c-sis (Sis, PDGFB), encoding the B chain of platelet-derived growth factor, has been cloned. Its structure, with seven exons spanning approximately 20 kb, closely resembles that of the human and feline homologs...
  61. ncbi Assignment of the Ly-6--Ril-1--Sis--H-30--Pol-5/Xmmv-72--Ins-3--Krt-1--Int-1 --Gdc-1 region to mouse chromosome 15
    D Meruelo
    Immunogenetics 25:361-72. 1987
    ..restriction fragment length polymorphisms were defined associated with several loci, including Pol-5, Ly-6, Sis, Ins-3, Krt-1, Int-1, and Gdc-1...
  62. ncbi Myc-1 is centromeric to the linkage group Ly-6--Sis--Gdc-1 on mouse chromosome 15
    K Huppi
    Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892
    Immunogenetics 27:215-9. 1988
    ..Mus musculus domesticus and BALB/cJ permitted the positioning of Myc-1 on chromosome 15 with respect to Ly-6, Sis, and Gdc-1...
  63. ncbi Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
    M D Waterfield
    Nature 304:35-9. 1983
    ..This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors...
  64. ncbi Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation
    M C Bidwell
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Endocrinology 136:5189-201. 1995
    ....
  65. ncbi Chromosomal localisation, inducibility, tissue-specific expression and strain differences in three murine peroxisome-proliferator-activated-receptor genes
    P S Jones
    Department of Life Science, University of Nottingham, England
    Eur J Biochem 233:219-26. 1995
    ..Polymorphism in the size of PPAR alpha RNA from Swiss-Webster mice was detected, and shown to be due to a 2-bp mutation in the 3' non-coding region of PPAR alpha in Swiss Webster mice...
  66. ncbi Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog
    V Marigo
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genomics 28:44-51. 1995
    ..Shh mapped to a position 0.6 cM distal to En2 and 1.9 cM proximal to Il6 on mouse chromosome 5. This location is closely linked but distinct from the murine limb mutation Hx and syntenic to human chromosome 7q36...
  67. ncbi A novel, conserved gene of the rat that is developmentally regulated in the testis
    L Walter
    Division of Immunogenetics, University of Gottingen, Germany
    Mamm Genome 5:216-21. 1994
    ..Analysis of rat RNA from different stages of spermatogenesis indicated that accumulation of the short transcript occurred mainly postmeiotically. The rat Tegt gene maps to Chromosome (Chr) 7, and its mouse homolog to Chr 15...
  68. ncbi Genetic mapping of Pp11r, a thymocyte gene expressed during apoptosis, to mouse chromosome 15
    S F Kingsmore
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Mamm Genome 4:459-60. 1993
  69. ncbi Overexpression of PDGF-B in murine hematopoietic cells induces a lethal myeloproliferative syndrome in vivo
    X Q Yan
    Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, Canada
    Oncogene 9:163-73. 1994
    ..The observations have important implications for projected gene therapy protocols, and identify a novel potential pathway to myeloproliferative disease...
  70. ncbi A murine homolog of the yeast RNA1 gene is required for postimplantation development
    J DeGregori
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2363
    Genes Dev 8:265-76. 1994
    ..These similarities suggest that Fug1 may be required for developmental changes in RNA processing or chromatin structure prior to gastrulation...
  71. ncbi Localization of the murine activating transcription factor 4 gene to mouse chromosome 15
    L M Mielnicki
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263
    Genomics 15:197-9. 1993
    ..the gene encoding murine activating transcription factor 4 (ATF-4) to mouse chromosome 15 in close proximity to Sis (the cellular homolog of the simian sarcoma virus oncoprotein)...
  72. ncbi A high-resolution genetic map of mouse chromosome 15 encompassing the Dominant megacolon (Dom) locus
    A Puliti
    Unité INSERM U91 Hôpital Henri Mondor, Creil, France
    Mamm Genome 6:763-8. 1995
    ..In this publication we report mapping the Dom locus with high definition, using several intra-and interspecific crosses and a set of 16 Chr 15-specific microsatellites flanking this locus...
  73. ncbi Platelet-derived growth factor B-chain homodimer suppressing a convulsion of epilepsy model mouse El
    Y Masuda
    Department of Neuropsychiatry, Akita University School of Medicine, Japan
    Biochem Biophys Res Commun 223:60-3. 1996
    ..These findings suggest that an abnormality in PDGF-BB release may make El mice susceptible to tonic-clonic convulsions...
  74. ncbi Viability of transgenic mice expressing a platelet derived growth factor (PDGF) antagonist in plasma
    X Liao
    Daiichi Research Center, Cardiovascular Research Institute, San Francisco, CA, USA
    J Investig Med 44:139-43. 1996
    ..Previously, we showed in tissue culture that the soluble extracellular domain of the PDGF beta-receptor is capable of binding BB-PDGF with high affinity; therefore antagonizing the ability of BB-PDGF to stimulate cell growth...
  75. ncbi Lens-specific expression of PDGF-A alters lens growth and development
    L W Reneker
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Dev Biol 180:554-65. 1996
    ..Elevated levels of PDGF-A enhance proliferation, but also appear to induce some aspects of the fiber cell differentiation pathway...
  76. ncbi Genetic and physical maps of the stargazer locus on mouse chromosome 15
    V A Letts
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genomics 43:62-8. 1997
    ..A physical contig of YACs, BACs, and P1s stretching 1.1 Mb from D15Mit30 to the somatostatin receptor 3 gene is reported, and the DNA interval including the stargazer locus has been narrowed to 150 kb...
  77. ncbi Activation of NF-kappaB is required for PDGF-B chain to transform NIH3T3 cells
    Takeshi Shimamura
    Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan 49008, USA
    Exp Cell Res 274:157-67. 2002
    ..Therefore, the transcription factor NF-kappaB plays a vital role in PDGF-B chain transformation of mouse fibroblast cells, and the NF-kappaB activity is sensitive to treatment with ASA...
  78. ncbi Desensitization of the PDGFbeta receptor by modulation of the cytoskeleton: the role of p21(Ras) and Rho family GTPases
    Ligaya L Stice
    Cancer Research Center and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Exp Cell Res 275:17-30. 2002
    ....
  79. ncbi Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor
    Yuji Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    J Biol Chem 277:23216-22. 2002
    ..Because PDGF-mediated ERK activation is enhanced in Chinese hamster ovary cells that overexpress Gab1, Gab1 serves as an important link between PKC and ERK activation by PDGFbeta receptors in VSMC...
  80. ncbi Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury
    Sekiko Taneda
    Department of Pathology, University of Washington, Seattle, Washington, USA
    J Am Soc Nephrol 14:2544-55. 2003
    ..These observations suggest that PDGF-D plays an important role in the pathogenesis of tubulointerstitial injury through binding of PDGF-Rbeta in both human obstructive nephropathy and the corresponding murine model of UUO...
  81. ncbi Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes
    Munira Xaymardan
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Circ Res 94:E39-45. 2004
    ..Strategies based on the synergistic interactions of PDGF-AB and endogenous stem cells will need to maintain cellular patterning in order to promote the restoration of cardiac function after acute coronary occlusion...
  82. pmc Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase
    Camilla Persson
    Ludwig Institute for Cancer Research, Uppsala Branch, Biomedical Center, S 751 24 Uppsala, Sweden
    Mol Cell Biol 24:2190-201. 2004
    ..In summary, our findings identify TC-PTP as a previously unrecognized negative regulator of PDGF beta receptor signaling and support the general notion that PTPs display site selectivity in their action on tyrosine kinase receptors...
  83. ncbi The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated chemotaxis of embryonic fibroblasts on collagens
    Svetlana N Popova
    Department of Medical Biochemistry and Microbiology, Biomedical Center, Uppsala, Sweden
    Dev Biol 270:427-42. 2004
    ....
  84. ncbi Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis
    Tatiana V Petrova
    Molecular Cancer Biology Laboratory and Ludwig Institute for Cancer Research, Biomedicum Helsinki and Helsinki University Central Hospital, University of Helsinki, Haartmaninkatu 8, P O B 63, 00014 Helsinki, Finland
    Nat Med 10:974-81. 2004
    ..Our results indicate that an abnormal interaction between the lymphatic endothelial cells and pericytes, as well as valve defects, underlie the pathogenesis of LD...
  85. ncbi alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB
    En Shu
    Department of Pharmacology, Gifu University Graduate School of Medicine, Japan
    Arch Biochem Biophys 438:111-8. 2005
    ..Our results indicate that PDGF-BB induces phosphorylation of alphaB-crystallin via p38 MAP kinase during myocardial infarction...
  86. ncbi Quantitative trait loci for proteinuria in the focal glomerulosclerosis mouse model
    Eun Hee Kim
    Laboratory of Animal Genetics, Division of Applied Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi 464 8601, Japan
    Mamm Genome 16:242-50. 2005
    ..These results indicated that the genetic control of proteinuria is complex and the identified QTLs may provide new insights into the pathogenesis of FGS in mice as well as in humans...
  87. ncbi Limited mutations in full-length tetrameric human alpha2-macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-beta1
    Sanja Arandjelovic
    Department of Pathology, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 281:17061-8. 2006
    ..The exact sequences required for binding different growth factors may be non-identical, mimicking the model of the bait region in which different proteases target adjacent and sometimes overlapping sequences...
  88. ncbi Sorafenib inhibits imatinib-resistant KIT and platelet-derived growth factor receptor beta gatekeeper mutants
    Teresa Guida
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, Naples, Italy
    Clin Cancer Res 13:3363-9. 2007
    ..The aim of this study was to evaluate whether sorafenib (BAY 43-9006), a multitargeted ATP-competitive inhibitor of KIT and PDGFR, was active against imatinib-resistant KIT and PDGFRbeta kinases...
  89. pmc Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS
    Toshiharu Yamashita
    Department of Regenerative Medicine, Institute of Basic Medical Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba 305 8575, Japan
    Mol Cell Biol 28:1285-97. 2008
    ....
  90. doi Platelet-derived growth factor signals play critical roles in differentiation of longitudinal smooth muscle cells in mouse embryonic gut
    M Kurahashi
    Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Tsurumai, Showa Ku, Nagoya, Japan
    Neurogastroenterol Motil 20:521-31. 2008
    ..The selective PDGF receptor inhibitor AG1295 suppressed the differentiation of LMC in gut explants. We conclude that PDGF signals play critical roles in the differentiation of LMC in mouse embryonic gut...
  91. doi Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Am J Physiol Heart Circ Physiol 294:H2785-91. 2008
    ..In conclusion, these findings indicate that statin therapy might be useful for preventing intractable diabetic foot disease in patients with diabetic angiopathy...
  92. pmc IRS1-independent defects define major nodes of insulin resistance
    Kyle L Hoehn
    Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Cell Metab 7:421-33. 2008
    ..These findings indicate that while insulin resistance is associated with multiple deficiencies, the most deleterious defects and the origin of insulin resistance occur independently of IRS...
  93. doi Coronary development is regulated by ATP-dependent SWI/SNF chromatin remodeling component BAF180
    Xuling Huang
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Richard Simches Research Center, 185 Cambridge Street, Boston, MA 02114, USA
    Dev Biol 319:258-66. 2008
    ..Together, these data reveal for the first time that BAF180 is critical for coronary vessel formation...
  94. doi Spinal glioma: platelet-derived growth factor B-mediated oncogenesis in the spinal cord
    Yasuyuki Hitoshi
    Departments of Pediatrics and Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, USA
    Cancer Res 68:8507-15. 2008
    ..Expression of PDGFB is thought to be important in the pathogenesis of glioma and several animal models of cerebral glioma based on ..
  95. doi The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF)
    Alex Daviau
    Departement de Biologie, Faculte des Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1K 2R1
    Cell Signal 21:577-87. 2009
    ..Thus, our findings suggest that Src-dependent tyrosine phosphorylation of DLK may be important for regulation of its activity, and they support a role for DLK in PDGF signaling...
  96. doi VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B
    Mitsuho Onimaru
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Am J Physiol Heart Circ Physiol 297:H1685-96. 2009
    ....
  97. pmc Laminin alpha4-null mutant mice develop chronic kidney disease with persistent overexpression of platelet-derived growth factor
    Christine K Abrass
    Primary and Specialty Care Medicine, Department of Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA
    Am J Pathol 176:839-49. 2010
    ..Given the recent demonstration that individuals with laminin alpha4 mutations develop cardiomyopathy, these findings may be relevant to kidney disease in humans...
  98. doi Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasia
    Franck Lebrin
    Institut National de la Santé et de la Recherche Médicale U833, College de France, Paris, France
    Nat Med 16:420-8. 2010
    ..Our findings demonstrate the ability of thalidomide to induce vessel maturation, which may be useful as a therapeutic strategy for the treatment of vascular malformations...
  99. doi Liver specific overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis
    Thorsten Maass
    Department of Medicine I, Johannes Gutenberg University, Mainz, Germany
    Int J Cancer 128:1259-68. 2011
    ..We were able to extend the understanding of key genetic regulators in HCC development by PDGF-B and decode essential downstream signals...

Research Grants2

  1. GLOMERULAR LAMININS: STRUCTURE AND FUNCTION
    Christine Abrass; Fiscal Year: 2003
    ....
  2. Molecular Mechanisms of Mesangial Sclerosis
    Christine Abrass; Fiscal Year: 2009
    ..Understanding transcriptional control of LN isoform expression will add new insights into the role that LN plays in normal glomerulogenesis and that becomes disordered in glomerular disease. ..