Genomes and Genes
Gene Symbol: Pde11a
Description: phosphodiesterase 11A
Alias: 6330414F14Rik, A630086N24Rik, Gm350, PDE11A1, dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A
- PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brainShweta Hegde
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29209, United States
Neuroscience 335:151-69. 2016..Here, we determine if Phosphodiesterase 11A (PDE11A), an enzyme that is enriched in the ventral hippocampal formation (VHIPP) and that breaks down cAMP and cGMP, ..
- Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiologyC Wayman
Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent, UK
Int J Impot Res 17:216-23. 2005..These data are consistent with human data and suggest a role for PDE11 in spermatogenesis and fertilization potential. This is the first phenotype described for the PDE11-/- mouse and the first report of a physiological role for PDE11...
- Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypesMichele P Kelly
Pfizer Research, Princeton, NJ 08852, USA
Proc Natl Acad Sci U S A 107:8457-62. 2010Phosphodiesterase 11A (PDE11A) is the most recently identified family of phosphodiesterases (PDEs), the only known enzymes to break down cyclic nucleotides...
- Overview of PDEs and their regulationKenji Omori
Discovery Research Laboratories, Tanabe Seiyaku Co Ltd, 2 50 Kawagishi 2 chome, Toda, Saitama 335 8505, Japan
Circ Res 100:309-27. 2007..Each unique variant is closely related to the regulation of a specific cellular signaling. Thus, multiple PDEs function as a particular modulator of each cardiovascular function and regulate physiological homeostasis...