Pde11a

Summary

Gene Symbol: Pde11a
Description: phosphodiesterase 11A
Alias: 6330414F14Rik, A630086N24Rik, Gm350, PDE11A1, dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A, cAMP and cGMP phosphodiesterase 11A
Species: mouse

Top Publications

  1. pmc PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain
    Shweta Hegde
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29209, United States
    Neuroscience 335:151-69. 2016
  2. ncbi Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology
    C Wayman
    Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent, UK
    Int J Impot Res 17:216-23. 2005
  3. pmc Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes
    Michele P Kelly
    Pfizer Research, Princeton, NJ 08852, USA
    Proc Natl Acad Sci U S A 107:8457-62. 2010
  4. ncbi Overview of PDEs and their regulation
    Kenji Omori
    Discovery Research Laboratories, Tanabe Seiyaku Co Ltd, 2 50 Kawagishi 2 chome, Toda, Saitama 335 8505, Japan
    Circ Res 100:309-27. 2007

Scientific Experts

Detail Information

Publications4

  1. pmc PDE11A regulates social behaviors and is a key mechanism by which social experience sculpts the brain
    Shweta Hegde
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, SC 29209, United States
    Neuroscience 335:151-69. 2016
    ..Here, we determine if Phosphodiesterase 11A (PDE11A), an enzyme that is enriched in the ventral hippocampal formation (VHIPP) and that breaks down cAMP and cGMP, ..
  2. ncbi Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology
    C Wayman
    Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent, UK
    Int J Impot Res 17:216-23. 2005
    ..These data are consistent with human data and suggest a role for PDE11 in spermatogenesis and fertilization potential. This is the first phenotype described for the PDE11-/- mouse and the first report of a physiological role for PDE11...
  3. pmc Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes
    Michele P Kelly
    Pfizer Research, Princeton, NJ 08852, USA
    Proc Natl Acad Sci U S A 107:8457-62. 2010
    Phosphodiesterase 11A (PDE11A) is the most recently identified family of phosphodiesterases (PDEs), the only known enzymes to break down cyclic nucleotides...
  4. ncbi Overview of PDEs and their regulation
    Kenji Omori
    Discovery Research Laboratories, Tanabe Seiyaku Co Ltd, 2 50 Kawagishi 2 chome, Toda, Saitama 335 8505, Japan
    Circ Res 100:309-27. 2007
    ..Each unique variant is closely related to the regulation of a specific cellular signaling. Thus, multiple PDEs function as a particular modulator of each cardiovascular function and regulate physiological homeostasis...