Pcna

Summary

Gene Symbol: Pcna
Description: proliferating cell nuclear antigen
Alias: proliferating cell nuclear antigen, cyclin
Species: mouse

Top Publications

  1. ncbi Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell
    S Sakakibara
    Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Dev Biol 176:230-42. 1996
  2. doi NKX2.1 specifies cortical interneuron fate by activating Lhx6
    Tonggong Du
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Development 135:1559-67. 2008
  3. doi Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development
    Jessica L MacDonald
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Dev Dyn 237:2256-67. 2008
  4. pmc An obligatory role of mind bomb-1 in notch signaling of mammalian development
    Bon Kyoung Koo
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
    PLoS ONE 2:e1221. 2007
  5. ncbi Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia
    Jasmine C Y Wong
    Program in Genetics and Genomics Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Hum Mol Genet 12:2063-76. 2003
  6. pmc Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity
    Hiroki Shiwaku
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    EMBO J 29:2446-60. 2010
  7. pmc Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis
    Zahra Kadri
    CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay aux Roses, France
    PLoS Biol 7:e1000123. 2009
  8. ncbi Expression profiles of Insulin-like growth factor binding protein-like 1 in the developing mouse forebrain
    Yuko Gonda
    Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Gene Expr Patterns 7:431-40. 2007
  9. doi Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon
    Daichi Kawaguchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:3849-58. 2008
  10. doi Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling
    Ilkka Pietilä
    Oulu Center for Cell Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Oulu, Finland
    Dev Biol 353:50-60. 2011

Research Grants

  1. IR-INDUCED APOPTOSIS IN THE DEVELOPING NERVOUS SYSTEM
    PETER MCKINNON; Fiscal Year: 2004
  2. Molecular Development of the Endolymphatic Duct and Sac
    Daniel Choo; Fiscal Year: 2005
  3. The cell cycle in ototoxin induced hair cell death.
    Neil Segil; Fiscal Year: 2007
  4. ATM and DNA Damage in the Nervous System
    PETER MCKINNON; Fiscal Year: 2007
  5. Ocular defects caused by TCF8/Zfhx1a mutations
    Douglas Darling; Fiscal Year: 2008
  6. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
  7. Pathogenic Mechanism of Polycystic Kidney Disease
    Yumay Chen; Fiscal Year: 2010
  8. TRANSCRIPTION FACTORS REGULATING PALATOGENESIS
    Douglas Darling; Fiscal Year: 2002
  9. Marking hair cell progenitors with BAC transgenics
    Neil Segil; Fiscal Year: 2004
  10. Identifying Periodontal Antigens By Protein Microarray
    Douglas Darling; Fiscal Year: 2006

Detail Information

Publications141 found, 100 shown here

  1. ncbi Mouse-Musashi-1, a neural RNA-binding protein highly enriched in the mammalian CNS stem cell
    S Sakakibara
    Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Dev Biol 176:230-42. 1996
    ....
  2. doi NKX2.1 specifies cortical interneuron fate by activating Lhx6
    Tonggong Du
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Development 135:1559-67. 2008
    ..1. The slice transfection and transplantation methods employed here are beginning to uncover embryonic mechanisms for specifying neuronal fates that only become definable postnatally...
  3. doi Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development
    Jessica L MacDonald
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Dev Dyn 237:2256-67. 2008
    ..These results identify key developmental stages of HDAC expression and suggest transitions of neural development that may utilize HDAC1 and/or HDAC2...
  4. pmc An obligatory role of mind bomb-1 in notch signaling of mammalian development
    Bon Kyoung Koo
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk, South Korea
    PLoS ONE 2:e1221. 2007
    ..However, the respective roles of the mammalian E3 ubiquitin ligases, Neur1, Neur2, Mib1, and Mib2, in mammalian development are poorly understood...
  5. ncbi Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia
    Jasmine C Y Wong
    Program in Genetics and Genomics Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
    Hum Mol Genet 12:2063-76. 2003
    ..Taken together, our results suggest that the FA pathway plays a role in the maintenance of reproductive germ cells and in meiotic recombination...
  6. pmc Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity
    Hiroki Shiwaku
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    EMBO J 29:2446-60. 2010
    ..Maxer anchors CDK5RAP3 to the ER and inhibits its function of Cyclin D1 transcription repression in the nucleus. The loss of Maxer eventually induces cell accumulation at G1 phase...
  7. pmc Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis
    Zahra Kadri
    CEA, Institute of Emerging Diseases and Innovative Therapies, Fontenay aux Roses, France
    PLoS Biol 7:e1000123. 2009
    ..These findings clarify the previously suspected cell-autonomous role of pRb during erythropoiesis and may provide a unifying molecular mechanism for several mouse phenotypes and human diseases associated with GATA-1 mutations...
  8. ncbi Expression profiles of Insulin-like growth factor binding protein-like 1 in the developing mouse forebrain
    Yuko Gonda
    Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Gene Expr Patterns 7:431-40. 2007
    ..In postnatal stages, mRNA was found only in the granule cell layer of the dentate gyrus (DG). Notably, at P20, expression was restricted to the deep fraction of the granule cell layer, the location of late-born DG neurons...
  9. doi Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon
    Daichi Kawaguchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:3849-58. 2008
    ....
  10. doi Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling
    Ilkka Pietilä
    Oulu Center for Cell Matrix Research, Biocenter Oulu, Laboratory of Developmental Biology and Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Oulu, Finland
    Dev Biol 353:50-60. 2011
    ..Based on the results, we propose that Dkk1 controls the degree of Wnt-7b signalling in the papilla to coordinate kidney organogenesis...
  11. pmc Onecut 1 and Onecut 2 are potential regulators of mouse retinal development
    Fuguo Wu
    Department of Ophthalmology Ross Eye Institute, University at Buffalo, Buffalo, New York 14203, USA
    J Comp Neurol 520:952-69. 2012
    ..Furthermore, we showed that Oc1 and Oc2 were expressed in both developing and mature horizontal cells (HCs). Therefore the two factors may also function in the genesis and maintenance of HCs...
  12. pmc Repressor element 1 silencing transcription factor (REST) controls radial migration and temporal neuronal specification during neocortical development
    Gail Mandel
    Department of Neurobiology and Behavior, and Howard Hughes Medical Institute, State University of New York, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 108:16789-94. 2011
    ....
  13. ncbi Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone
    Marie Catherine Tiveron
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
    J Neurosci 26:13273-8. 2006
    ..These results represent the first evidence for a molecular interaction between precursors of projection neurons and invading interneurons during corticogenesis...
  14. pmc The nuclear receptor Nor-1 is essential for proliferation of the semicircular canals of the mouse inner ear
    Tiia Ponnio
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:935-45. 2002
    ....
  15. pmc Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice
    Li Zheng
    City of Hope National Medical Center, Department of Molecular Biology, 1500 East Duarte Rd, Duarte, CA 91010, USA
    Mol Cell Biol 27:3176-86. 2007
    The interaction between flap endonuclease 1 (FEN-1) and proliferation cell nuclear antigen (PCNA) is critical for faithful and efficient Okazaki fragment maturation...
  16. doi Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex
    Lilla M Farkas
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Neuron 60:40-55. 2008
    ..Our data imply that Insm1 is involved in the generation and expansion of basal progenitors, a hallmark of neocortex evolution...
  17. pmc Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development
    Branden R Nelson
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Dev Dyn 238:2163-78. 2009
    ..Thus, these results suggest a molecular mechanism whereby attenuated Notch levels coupled with reduced proneurogenic activity in progenitors leads to increased gliogenesis and decreased neurogenesis in the Ascl1-deficient retina...
  18. pmc Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene
    M Mikula
    Department of Cell and Microbiology, Institute of Microbiology and Genetics and Research Institute of Molecular Pathology, Vienna Biocenter, 1030 Vienna, Austria
    EMBO J 20:1952-62. 2001
    ..These results indicate that the essential function of Raf-1 is to counteract apoptosis rather than to promote proliferation, and that effectors distinct from the MEK/ERK cascade must mediate the anti-apoptotic function of Raf-1...
  19. pmc Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia
    Aric W Ledford
    Department of Biology, East Carolina University, Greenville, NC 27858, USA
    Dev Biol 245:157-71. 2002
    ..in more highly differentiated tubules and glomeruli, and this was associated with reduced expression of the cyclin kinase inhibitor, p27...
  20. ncbi Aberrant trajectory of ascending dopaminergic pathway in mice lacking Nkx2.1
    Hitoshi Kawano
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, 183 8526, Japan
    Exp Neurol 182:103-12. 2003
    ..1-deficient mice, the abnormal crossing of ascending DA axons observed may be attributed to the elimination of these chemorepulsive signals in the medial part of the mutant hypothalamus...
  21. ncbi Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium
    Christine Carson
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Dev Dyn 235:1678-88. 2006
    ..Notch 2 and Notch 1/3 may, therefore, have different roles in the commitment and differentiation of neuronal and glial lineages of the OE during development, and the maintenance of non-neuronal phenotypes postnatally...
  22. ncbi YB-1 is important for an early stage embryonic development: neural tube formation and cell proliferation
    Takeshi Uchiumi
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 281:40440-9. 2006
    ..These results demonstrate that YB-1 is involved in early mouse development, including neural tube closure and cell proliferation...
  23. ncbi PCNA: structure, functions and interactions
    Z Kelman
    Johns Hopkins School of Medicine, Department of Molecular Biology and Genetics, Baltimore, Maryland 21205, USA
    Oncogene 14:629-40. 1997
    b>Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the replication and repair machinery. This toroidal-shaped protein encircles DNA and can slide bidirectionally along the duplex...
  24. ncbi Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Cancer Res 59:1206-11. 1999
    ..The mouse strain described here should provide a valuable experimental model to analyze the function of tuberin and its association with tumorigenesis...
  25. pmc A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    C Fode
    Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
    Genes Dev 14:67-80. 2000
    ....
  26. ncbi p27(Kip1) regulates cell cycle withdrawal of late multipotent progenitor cells in the mammalian retina
    E M Levine
    Department of Biological Structure, University of Washington, Seattle, Washington, 98195, USA
    Dev Biol 219:299-314. 2000
    The cyclin-dependent kinase inhibitor protein, p27(Kip1), is necessary for the timing of cell cycle withdrawal that precedes terminal differentiation in oligodendrocytes of the optic nerve...
  27. ncbi DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
    M R Rountree
    The Johns Hopkins Oncology Center, Tumor Biology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Genet 25:269-77. 2000
    ..Thus, DNMT1 not only maintains DNA methylation, but also may directly target, in a heritable manner, transcriptionally repressive chromatin to the genome during DNA replication...
  28. ncbi Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
    M Sander
    Hormone Research Institute, University of California San Francisco, San Francisco, CA 94143 0534, USA
    Development 127:5533-40. 2000
    ..Together, these experiments reveal two independently controlled pathways for beta-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of beta-cell differentiation...
  29. ncbi The transcription factors L-Sox5 and Sox6 are essential for cartilage formation
    P Smits
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Cell 1:277-90. 2001
    ..L-Sox5 and Sox6 are thus redundant, potent enhancers of chondroblast functions, thereby essential for endochondral skeleton formation...
  30. ncbi Direct interaction between mammalian DNA polymerase beta and proliferating cell nuclear antigen
    Padmini S Kedar
    Laboratory of Structural Biology, NIEHS National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    J Biol Chem 277:31115-23. 2002
    b>Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the DNA replication and DNA repair machinery...
  31. ncbi BMP signaling is required for septation of the outflow tract of the mammalian heart
    Emmanuèle C Délot
    Department of Orthopaedic Surgery, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Development 130:209-20. 2003
    ..The more restricted spectrum of cardiac anomalies in Bmpr2(deltaE2) mutants makes this strain a key murine model to understand the embryonic defects of persistent truncus arteriosus and impaired semilunar valve formation in humans...
  32. pmc A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells
    Robert Y L Tsai
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genes Dev 16:2991-3003. 2002
    ..This work describes a novel nucleolar mechanism that controls the cell-cycle progression in CNS stem cells and cancer cells...
  33. pmc Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    Sanja Ivkovic
    Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095, USA
    Development 130:2779-91. 2003
    ..These results demonstrate that CTGF is important for cell proliferation and matrix remodeling during chondrogenesis, and is a key regulator coupling extracellular matrix remodeling to angiogenesis at the growth plate...
  34. ncbi Beta-catenin is temporally regulated during normal liver development
    Amanda Micsenyi
    Department of Pathology, University of Pittsburgh, School of Medicine, PA 15261, USA
    Gastroenterology 126:1134-46. 2004
    ..beta-Catenin, a key component of the Wnt pathway, plays an important role in unregulated liver growth in liver tumors, in regulated growth during liver regeneration, and in ex vivo embryonic liver cultures...
  35. ncbi Dynamics of Cux2 expression suggests that an early pool of SVZ precursors is fated to become upper cortical layer neurons
    Celine Zimmer
    Developmental Biology Institute of Marseille, NMDA, Campus de Luminy Case 907, 13288 Marseille Cedex 9, France
    Cereb Cortex 14:1408-20. 2004
    ..This suggests that laminar determination of upper cortical layer neurons occurs during the earliest stages of corticogenesis...
  36. ncbi Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse
    Yasushi Ohkubo
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 24:6057-69. 2004
    ..We conclude that Fgfr1 is necessary for hippocampal growth, because it promotes the proliferation of hippocampal progenitors and stem cells during development...
  37. ncbi Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis
    Ben Martynoga
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Dev Biol 283:113-27. 2005
    ....
  38. ncbi Essential role for survivin in early brain development
    Yuying Jiang
    Center for Childhood Cancer, Columbus Children s Research Institute, Columbus, Ohio 43205, USA
    J Neurosci 25:6962-70. 2005
    ..Our study is the first to solidify a role for survivin as an antiapoptotic protein during normal neuronal development in vivo...
  39. ncbi The activity of the spinal muscular atrophy protein is regulated during development and cellular differentiation
    Francesca Gabanella
    Dulbecco Telethon Institute, Institute of Cell Biology CNR, Rome, Italy
    Hum Mol Genet 14:3629-42. 2005
    ..These results demonstrate that the SMN complex activity in snRNP assembly is regulated and point to a differential requirement for SMN function during development and cellular differentiation...
  40. pmc Rapid and quantitative detection of homologous and non-homologous recombination events using three oligonucleotide MLPA
    Petra Langerak
    Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nucleic Acids Res 33:e188. 2005
    ..in ES cell clones targeted with two different constructs: one introduces a single nucleotide change in the PCNA gene and the other allows for a conditional inactivation of the wild-type PCNA allele...
  41. ncbi Patched1 functions as a gatekeeper by promoting cell cycle progression
    Christelle Adolphe
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Cancer Res 66:2081-8. 2006
    ..of Ptch1, however, a large proportion of basal cells exhibit nuclear accumulation of the cell cycle regulators cyclin D1 and B1...
  42. pmc Rad18 regulates DNA polymerase kappa and is required for recovery from S-phase checkpoint-mediated arrest
    Xiaohui Bi
    Department of Genetics and Genomics, Boston University School of Medicine, 80 E Concord St, Boston, MA 02118, USA
    Mol Cell Biol 26:3527-40. 2006
    ..The DNA polymerase processivity factor PCNA is monoubiquitinated and interacts with Polkappa in cells treated with the bulky adduct-forming genotoxin benzo[a]..
  43. pmc SOX2 is a dose-dependent regulator of retinal neural progenitor competence
    Olena V Taranova
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA
    Genes Dev 20:1187-202. 2006
    ....
  44. ncbi REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 23:265-71. 2006
    ..Here, we report that mouse REV1 can bind directly to PCNA and that monoubiquitylation of PCNA enhances this interaction...
  45. pmc Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development
    Guetchyn Millien
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, USA
    BMC Dev Biol 6:35. 2006
    ..Since little is known about the molecular pathways driving alveolar sacculation, we used expression microarrays to identify genes altered in the abnormal lungs and, by inference, may play roles in normal lung morphogenesis...
  46. ncbi BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways
    Byeong S Yoon
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 133:4667-78. 2006
    ..These results provide a genetic in vivo demonstration that the progression of chondrocytes through the growth plate is controlled by antagonistic BMP and FGF signaling pathways...
  47. pmc A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification
    Petra Langerak
    The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Exp Med 204:1989-98. 2007
    ..Monoubiquitination at lysine(164) of proliferating cell nuclear antigen (PCNA(K164)) stimulates TLS...
  48. pmc Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina
    Anna M Clark
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT, USA
    Brain Res 1192:99-113. 2008
    ....
  49. ncbi Requirements for the interaction of mouse Polkappa with ubiquitin and its biological significance
    Caixia Guo
    Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    J Biol Chem 283:4658-64. 2008
    ..In addition, Polkappa binds with monoubiquitinated proliferating cell nuclear antigen (PCNA) more robustly than with non-ubiquitinated PCNA...
  50. pmc Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation
    Haotian Zhao
    Graduate Program in Molecular, Cellular and Developmental Biology, College of Biological Sciences, The Ohio State University, Columbus, OH 43210, USA
    Dev Biol 318:276-88. 2008
    ..Therefore, while signaling by FGF receptors is essential for lens fiber differentiation, different FGF receptors function redundantly...
  51. pmc Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
    Sergio Roa
    Departments of Cell Biology and Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:16248-53. 2008
    ..The scaffolding properties of proliferating cell nuclear antigen (PCNA) and ubiquitylation of its residue K164 have been suggested to play an important role ..
  52. doi Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors
    Jeremy N Pulvers
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 136:1859-68. 2009
    ..Our results show that Brca1 is required for the cerebral cortex to develop to normal size by preventing the apoptosis of early cortical progenitors and their immediate progeny...
  53. pmc Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
    Gaurav Das
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Neural Dev 4:15. 2009
    ..The cell cycle regulator cyclin D1 is expressed in RPCs, and mice with a targeted null allele at the cyclin D1 locus (Ccnd1-/-) have ..
  54. pmc A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Genet 41:891-8. 2009
    ....
  55. pmc Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub during somatic hypermutation
    Peter H L Krijger
    Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Exp Med 206:2603-11. 2009
    ..by the Ung2-dependent pathway and the generation of A/T mutations by the Msh2/ubiquitinated proliferating cell nuclear antigen (PCNA-Ub)-dependent pathway...
  56. pmc Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality
    Yaoqian Pan
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, United States
    Biochem Biophys Res Commun 408:369-74. 2011
    ..5. Expression of most miRNAs examined was compromised in VSMCs of Dicer KO. Our results indicate that Dicer is required for vascular development and regulates vascular remodeling by modulating VSMC proliferation and differentiation...
  57. pmc Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis
    Ozlem Karalay
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology Zurich, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 108:5807-12. 2011
    ....
  58. pmc DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice
    Zixuan Chen
    Department of Physiology, Campbell Clinic, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 287:19018-28. 2012
    ..Our results indicate that the DGCR8 gene is required for vascular development through the regulation of VSMC proliferation, apoptosis, and differentiation...
  59. pmc Fibroblast growth factor receptor-mediated activation of AKT-β-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells
    Nirmala Mavila
    Saban Research Institute, Children s Hospital Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e50401. 2012
    ....
  60. ncbi Developmental regulation of various annexins in the embryonic palate of the mouse: dexamethasone affects expression of annexin-1
    K P Chepenik
    Department of Anatomy, Jefferson Medial College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Craniofac Genet Dev Biol 15:171-81. 1995
    ..These data permit the suggestion that lipocortin I plays some critical, but as yet undefined, role in modulating ontogeny of the murine palate...
  61. ncbi Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin
    B Duvillie
    Medical Research Council Group in Fetal and Neonatal Health and Development, Lawson Health Research Institute, London, Ontario, Canada N6A4V2
    Endocrinology 143:1530-7. 2002
    ..Immunohistochemistry for proliferating cell nuclear antigen within the pancreatic ductal epithelium showed no differences in labeling index between insulin-..
  62. pmc Cartilage link protein 1 (Crtl1), an extracellular matrix component playing an important role in heart development
    Elaine E Wirrig
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Dev Biol 310:291-303. 2007
    ..Combined, these findings establish an important role for Crtl1 in heart development...
  63. doi Targeted disruption of Sonic Hedgehog in the mouse adrenal leads to adrenocortical hypoplasia
    Saunders Ching
    Department of Human Genetics, University of California, Los Angeles, California, USA
    Genesis 47:628-37. 2009
    ..Taken together, these results establish a direct role for Shh signaling in normal adrenal development...
  64. ncbi Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice
    L J Muglia
    Departments of Pediatrics and Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Respir Cell Mol Biol 20:181-8. 1999
    ....
  65. ncbi Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
    J Chen
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:317-28. 1998
    ..Like BRCA1 and RAD51, BRCA2 relocates to PCNA+ replication sites following exposure of S phase cells to hydroxyurea or UV irradiation...
  66. ncbi The mahogany protein is a receptor involved in suppression of obesity
    D L Nagle
    Millennium Pharmaceuticals, Inc, Cambridge, Massachusetts 02139, USA
    Nature 398:148-52. 1999
    ....
  67. ncbi Submandibular gland morphogenesis: stage-specific expression of TGF-alpha/EGF, IGF, TGF-beta, TNF, and IL-6 signal transduction in normal embryonic mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-r null mutations
    T Jaskoll
    Laboratory for Developmental Genetics, University of Southern California, Los Angeles, California, 90089, USA
    Anat Rec 256:252-68. 1999
    ..These and other findings provide insight into the design of future functional studies...
  68. ncbi A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos
    T Iwata
    Medical Genetics Branch, National Human Genome Research Institute, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Hum Mol Genet 9:1603-13. 2000
    ..This model was successfully crossed with a cartilage-specific CRE: transgenic strain, excluding the lung as the primary cause of lethality...
  69. pmc Abnormal adherence junctions in the heart and reduced angiogenesis in transgenic mice overexpressing mutant type XIII collagen
    M Sund
    Collagen Research Unit, Biocenter Oulu, Department of Medical Biochemistry, University of Oulu, PL 5000, 90014 Oulu, Finland
    EMBO J 20:5153-64. 2001
    ..These results indicate that type XIII collagen has an important role in certain adhesive interactions that are necessary for normal development...
  70. pmc Transcription factor gene AP-2 gamma essential for early murine development
    Uwe Werling
    Forschungszentrum Karlsruhe, ITG, Institute for Toxicology and Genetics, 76344 Eggenstein Leopoldshafen, Germany
    Mol Cell Biol 22:3149-56. 2002
    ..Therefore, AP-2 gamma seems to be required in early embryonic development because it regulates the genetic programs controlling proliferation and differentiation of extraembryonic trophectodermal cells...
  71. ncbi Tubedown-1 in remodeling of the developing vitreal vasculature in vivo and regulation of capillary outgrowth in vitro
    H Paradis
    Division of Basic Medical Sciences, Department of Medicine, Memorial University of Newfoundland, St John s NF, A1B 3V6, Canada
    Dev Biol 249:140-55. 2002
    ..The nuclei of vitreal vessel endothelial cells in TGF-beta2(-/-) eyes express proliferating cell nuclear antigen (PCNA) and exhibit increased levels of active (P42/44)mitogen-activated protein kinase (phospho-(P42/..
  72. ncbi Downregulation of NF-kappaB activity associated with alteration in proliferative response in the spleen after burn injury
    Ho H Phan
    Department of Surgery, University of California, Davis, California, USA
    Shock 23:73-9. 2005
    ..in proliferative activity in the red pulp of the spleen after injury as indicated by an increase in proliferating cell nuclear antigen (PCNA)...
  73. pmc Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo
    Yoh suke Mukouyama
    Howard Hughes Medical Institute and Division of Biology 216 76, California Institute of Technology, 1201 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:1551-6. 2006
    ..These results do not support the commonly held view that most neuroepithelial cells in the embryonic CNS VZ are stem cells in vivo...
  74. ncbi Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18
    Vincent M Christoffels
    Department of Experimental and Molecular Cardiology Group, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 98:1555-63. 2006
    ....
  75. ncbi Neogenin is expressed on neurogenic and gliogenic progenitors in the embryonic and adult central nervous system
    Daniel P Fitzgerald
    Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia
    Gene Expr Patterns 7:784-92. 2007
    ..In summary, this study demonstrates that Neogenin expression is a hallmark of many neural precursor populations (neurogenic and gliogenic) in both the embryonic and adult mammalian central nervous system...
  76. pmc Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication
    Michael S Y Huen
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 283:11073-7. 2008
    ..evidence to support that SET8 monomethylates Lys(20) of histone H4 during S phase by tethering to proliferating cell nuclear antigen via a putative proliferating cell nuclear antigen-interacting protein box...
  77. pmc Regulation of bone formation and remodeling by G-protein-coupled receptor 48
    Jian Luo
    The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
    Development 136:2747-56. 2009
    ..Together, our data demonstrate that Gpr48 regulates bone formation and remodeling through the cAMP-PKA-Atf4 signaling pathway...
  78. doi MBD2 and MeCP2 regulate distinct transitions in the stage-specific differentiation of olfactory receptor neurons
    Jessica L MacDonald
    Department of Zoology, Life Sciences Institute and Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Mol Cell Neurosci 44:55-67. 2010
    ..Thus, MBD2 and MeCP2 may mediate distinct, sequential transitions of ORN differentiation-an epigenetic mechanism that may be relevant to developmental regulation throughout the nervous system...
  79. doi Expression of cyclin E in postmitotic neurons during development and in the adult mouse brain
    Yayoi Ikeda
    Department of Histology and Cell Biology, Yokohama City University School of Medicine, Yokohama 236 0004, Japan
    Gene Expr Patterns 11:64-71. 2011
    ..Immunohistochemistry for the proliferating cell marker, proliferating cell nuclear antigen (PCNA) revealed that cyclin E was expressed by both proliferating and non-proliferating cells in the ..
  80. doi Epiplakin1 is expressed in the cholangiocyte lineage cells in normal liver and adult progenitor cells in injured liver
    Akira Matsuo
    Department of Stem Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Gene Expr Patterns 11:255-62. 2011
    ..Some of the Eppk1-positive cells express PCNA, a proliferation marker, thereby suggesting their identities as transient amplifying cells...
  81. pmc Cell polarity and spindle orientation in the distal epithelium of embryonic lung
    Ahmed H El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Children s Hospital Los Angeles, California, USA
    Dev Dyn 240:441-5. 2011
    ..These findings provide evidence for polarity in distal epithelial progenitors of embryonic lungs and provide a framework for future translationally oriented studies in this area...
  82. pmc Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium
    Richard C Krolewski
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA
    PLoS ONE 7:e51737. 2012
    ..Thus, persistent neurogenic failure distorts the differentiation of multiple other cell types in the olfactory epithelium...
  83. pmc c-Myc regulates cell proliferation during lens development
    Gabriel R Cavalheiro
    Programa de Biologia Celular e do Desenvolvimento, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 9:e87182. 2014
    ..Our findings support the conclusion that c-myc regulates the proliferation of lens epithelial cells in vivo and may, directly or indirectly, modulate the expression of classical cell cycle regulators in developing mouse lens. ..
  84. ncbi [Effect of seaweed pigment glycoprotein on the expression of PCNA and Bcl-2 protein in hepatocarcinoma cells in mice]
    Shuai Li
    Medical College of Qingdao University, Qingdao 266021, China
    Wei Sheng Yan Jiu 40:220-2. 2011
    To investigate the effect of seaweed pigment glycoprotein (SPG) on the expression of PCNA and Bcl-2 protein in hepatocarcinoma cells in mice.
  85. pmc Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes
    D Huang
    Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia 19104
    Mol Cell Biol 14:4233-43. 1994
    The proliferating-cell nuclear antigen (PCNA) gene encodes an auxiliary factor of DNA polymerase delta and functions in DNA replication during S phase. It is expressed at much higher levels in proliferating cells than in quiescent cells...
  86. pmc Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene
    D V Serreze
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Exp Med 180:1553-8. 1994
    ..Our analysis shows the utility of RCS and congenic stocks for the identification and isolation of non-MHC genes with strong antidiabetogenic functions...
  87. ncbi Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3
    W M ElShamy
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Neuron 21:1003-15. 1998
    ..Our results provide evidence for novel activity of neurotrophins in cell cycle control and point toward an N-myc sensitization to cell death in the nervous system that is under the control of NT-3...
  88. ncbi Myosin VIIa participates in opsin transport through the photoreceptor cilium
    X Liu
    Departments of Pharmacology and Neurosciences, University of California at San Diego School of Medicine, La Jolla, California 92093 0983, USA
    J Neurosci 19:6267-74. 1999
    ..They demonstrate that a myosin may function in a cilium and suggest that abnormal opsin transport might contribute to blindness in Usher syndrome...
  89. ncbi Developmental distribution of coxsackie virus and adenovirus receptor localized in the nervous system
    Yuko Hotta
    Department of Molecular Genetics, Genome Science Branch, Center for Bioresource based Researches, Brain Research Institute, Niigata University, Niigata, Japan
    Brain Res Dev Brain Res 143:1-13. 2003
    ..Based on our findings, we propose that mCAR is involved in migration and fasciculation during a restricted period as an adhesion molecule...
  90. pmc The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms
    Raffi Gugasyan
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Mol Cell Biol 24:5733-45. 2004
    ....
  91. ncbi An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis
    Christelle Adolphe
    Institute for Molecular Bioscience, and Special Research Centre for Functional and Applied Genomics, University of Queensland, Victoria, Australia
    Development 131:5009-19. 2004
    ....
  92. ncbi Effects of ultraviolet B exposure on the expression of proliferating cell nuclear antigen in murine skin
    Julian O Moore
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Photochem Photobiol 80:587-95. 2004
    b>Proliferating cell nuclear antigen (PCNA) is an active nuclear protein involved in DNA replication, recombination and repair. PCNA is found throughout the basal layer in normal skin and in all layers of the epidermis in malignancy...
  93. ncbi Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy)
    Luca Lambertini
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:292-9. 2005
    ..In the present study, we evaluated the protein expression of p53 and PCNA and DNA mutations of p53 and H-ras genes in both hyperplastic and neoplastic squamous cell lesions from the NTP ..
  94. ncbi The role of neurotrophins in the maintenance of the spinal cord motor neurons and the dorsal root ganglia proprioceptive sensory neurons
    Heather E Stephens
    Dalhousie University, Department of Anatomy and Neurobiology, 5850 College Street, Halifax, NS, Canada B3H 5X1
    Int J Dev Neurosci 23:613-20. 2005
    ....
  95. ncbi Time-dependent airway epithelial and inflammatory cell responses induced by influenza virus A/PR/8/34 in C57BL/6 mice
    John P Buchweitz
    Department of Pharmacology and Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Toxicol Pathol 35:424-35. 2007
    ..PR8 treatment resulted in airway epithelial cell regeneration as suggested by proliferating cell nuclear antigen (PCNA) positive staining at 7 and 10 dpi and mucous cell metaplasia (MCM) evident at 10, 15, and 21 ..
  96. ncbi Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center and Hospital, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90033, USA
    Dev Biol 308:421-37. 2007
    ..myocardium of Msx1-/-; Msx2-/- mutants is associated with premature down-regulation of p27(KIP1), an inhibitor of cyclin-dependent kinases...
  97. ncbi Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number
    Takashi Nakamura
    Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4370, USA
    J Biol Chem 283:4825-33. 2008
    ..Thus, Epfn has multiple functions for cell fate determination of the dental epithelium by regulating both proliferation and differentiation, preventing continuous tooth budding and generation...
  98. pmc SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
    Nesrine El-Bizri
    Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
    Development 135:2981-91. 2008
    ..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain...
  99. pmc Defective pulmonary vascular remodeling in Smad8 mutant mice
    Zheng Huang
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Hum Mol Genet 18:2791-801. 2009
    ..These findings implicate Smad8 in both pulmonary hypertension and lung tumorigenesis and support Smad8 as a candidate gene for PAH in humans...
  100. pmc Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy
    Dirk Bäumer
    MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 5:e1000773. 2009
    ....
  101. doi Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages
    Yayoi Shikata
    Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Dev Biol 349:147-59. 2011
    ..These data indicated that endogenous Ptch1 mediates the broad effects of Shh on the transition from VZ progenitors to IPCs and activation of proliferation of the IPCs in the cortex during late gestational stages...

Research Grants12

  1. IR-INDUCED APOPTOSIS IN THE DEVELOPING NERVOUS SYSTEM
    PETER MCKINNON; Fiscal Year: 2004
    ..Moreover, as neurodegenerative disease may engage similar apoptotic pathways, the findings from this proposal will be relevant for understanding neuronal death in neurodegenerative disease. ..
  2. Molecular Development of the Endolymphatic Duct and Sac
    Daniel Choo; Fiscal Year: 2005
    ..Significantly, this proposal includes challenging but achievable goals that will provide important knowledge to the field of inner ear development. ..
  3. The cell cycle in ototoxin induced hair cell death.
    Neil Segil; Fiscal Year: 2007
    ..Our earlier work suggested a role for the cell cycle machinery, in particular the cyclin-dependent kinase (CDK) inhibitor p19lnk4d, in maintaining the non-dividing state of hair cells and thus in ..
  4. ATM and DNA Damage in the Nervous System
    PETER MCKINNON; Fiscal Year: 2007
    ..abstract_text> ..
  5. Ocular defects caused by TCF8/Zfhx1a mutations
    Douglas Darling; Fiscal Year: 2008
    ..This directly relates to the National Eye Institute program's goal to investigate the development of the visual system. [unreadable] [unreadable] [unreadable]..
  6. C/EBP alpha in Aging Liver
    Nikolai Timchenko; Fiscal Year: 2009
    ..C/EBPalpha inhibits proliferation of young livers through direct interactions with cyclin dependent kinases 2 and 4. In adipose tissues, C/EBPalpha causes growth arrest via repression of E2F transcription...
  7. Pathogenic Mechanism of Polycystic Kidney Disease
    Yumay Chen; Fiscal Year: 2010
    ..Our studies will provide novel insight into the molecular pathogenesis of PKD. They will help explain why cysts progress at different rates and how therapies to slow the progression of PKD can be designed rationally. ..
  8. TRANSCRIPTION FACTORS REGULATING PALATOGENESIS
    Douglas Darling; Fiscal Year: 2002
    ..Subsequent work will investigate the molecular mechanism(s) of Zfhep action during craniofacial development. ..
  9. Marking hair cell progenitors with BAC transgenics
    Neil Segil; Fiscal Year: 2004
    ..In the Specific Aim 3, the same purified otic epithelial sub-populations will be profiled using micro-arrays to provide initial information about gene expression networks in the developing inner ear. ..
  10. Identifying Periodontal Antigens By Protein Microarray
    Douglas Darling; Fiscal Year: 2006
    ..The R21 Exploratory Grant is an appropriate mechanism since proteomics have not been used for periodontal disease, and bacterial genomic expression libraries and antigen microarrays need to be developed. [unreadable] [unreadable]..
  11. SELECTIVE AGGREGATION AND SORTING OF SALIVARY PROTEINS
    Douglas Darling; Fiscal Year: 2007
    ..This will lead to a better understanding of the formation of saliva and provide the basis for efficient delivery of therapeutic proteins from salivary glands. ..