Pax6

Summary

Gene Symbol: Pax6
Description: paired box 6
Alias: 1500038E17Rik, AEY11, Dey, Gsfaey11, Pax-6, Sey, paired box protein Pax-6, Dickie's small eye, oculorhombin, paired box gene 6
Species: mouse

Top Publications

  1. ncbi Transcription factors in glutamatergic neurogenesis: conserved programs in neocortex, cerebellum, and adult hippocampus
    Robert F Hevner
    Department of Pathology, University of Washington, Harborview Medical Center, Harborview Pathology, Box 359791, 325 Ninth Ave, Seattle, WA 98104, USA
    Neurosci Res 55:223-33. 2006
  2. pmc THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
  3. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
  4. ncbi The graded response to Sonic Hedgehog depends on cilia architecture
    Tamara Caspary
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 12:767-78. 2007
  5. pmc Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development
    Catherine L Prado
    Department of Pediatrics, Barbara Davis Center, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:2924-9. 2004
  6. ncbi Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
  7. pmc Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog
    Eric Dessaud
    Developmental Neurobiology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Biol 8:e1000382. 2010
  8. ncbi Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B
    J M Sivak
    Vision Research Laboratories of the New England Eye Center, Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Dev Biol 222:41-54. 2000
  9. ncbi Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 412:194-8. 2001
  10. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004

Detail Information

Publications201 found, 100 shown here

  1. ncbi Transcription factors in glutamatergic neurogenesis: conserved programs in neocortex, cerebellum, and adult hippocampus
    Robert F Hevner
    Department of Pathology, University of Washington, Harborview Medical Center, Harborview Pathology, Box 359791, 325 Ninth Ave, Seattle, WA 98104, USA
    Neurosci Res 55:223-33. 2006
    ..Our work has focused on Pax6, Tbr2/Eomes, NeuroD, and Tbr1, which are expressed sequentially during the neurogenesis of pyramidal-projection ..
  2. pmc THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
    Pamela V Tran
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, New Research Building, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 40:403-10. 2008
    ..Specifically, the aln mutation uncouples the roles of anterograde and retrograde transport in SHH signaling, suggesting that anterograde IFT is required for GLI activation and that retrograde IFT modulates this event...
  3. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
    ..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
  4. ncbi The graded response to Sonic Hedgehog depends on cilia architecture
    Tamara Caspary
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Dev Cell 12:767-78. 2007
    ..Thus, normal structure of the ciliary axoneme is required for the cell to translate different levels of Shh ligand into differential regulation of the Gli transcription factors that implement Hedgehog signals...
  5. pmc Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development
    Catherine L Prado
    Department of Pediatrics, Barbara Davis Center, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:2924-9. 2004
    ..2 and Pax4 are required to specify or maintain differentiation of the beta cell fate. This finding also suggests that there is a genetic component underlying the balance between insulin and ghrelin in regulating glucose metabolism...
  6. ncbi Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
    ..By contrast, we continue to postulate that prosomeres p1-p3 (i.e. the pretectum, thalamus and prethalamus) are the caudal forebrain...
  7. pmc Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog
    Eric Dessaud
    Developmental Neurobiology, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Biol 8:e1000382. 2010
    ..This suggests an alternative to conventional models of morphogen action that rely solely on the level of signalling...
  8. ncbi Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B
    J M Sivak
    Vision Research Laboratories of the New England Eye Center, Department of Ophthalmology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Dev Biol 222:41-54. 2000
    ..These data suggest a mechanism by which Pax-6 may direct gelB expression in an eye-specific manner...
  9. ncbi Rab23 is an essential negative regulator of the mouse Sonic hedgehog signalling pathway
    J T Eggenschwiler
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Nature 412:194-8. 2001
    ..The data indicate that dorsalizing signals activate transcription of Rab23 in order to silence the Shh pathway in dorsal neural cells...
  10. ncbi All mouse ventral spinal cord patterning by hedgehog is Gli dependent and involves an activator function of Gli3
    C Brian Bai
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Dev Cell 6:103-15. 2004
    ..Therefore, in the spinal cord all Hh signaling is Gli dependent. Furthermore, a combination of Gli2 and Gli3 is required to regulate motor neuron development and spatial patterning of ventral spinal cord progenitors...
  11. pmc Identification of pax6-dependent gene regulatory networks in the mouse lens
    Louise V Wolf
    Department of Ophthalmology, Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS ONE 4:e4159. 2009
    ..b>Pax6 is a paired domain and homeodomain-containing transcription factor essential for development of central nervous, ..
  12. pmc The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA
    Jovica Ninkovic
    Helmholtz Zentrum Munchen, Institute of Stem Cell Research, Ingolstädter Landstraße 1, D 85764 Neuherberg, Germany
    Neuron 68:682-94. 2010
    ..We show that the transcription factor Pax6 expressed in dopaminergic neurons of the olfactory bulb regulates the survival of these neurons by directly ..
  13. ncbi Pax6 is required for the multipotent state of retinal progenitor cells
    T Marquardt
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg 11, D 37077, Gottingen, Germany
    Cell 105:43-55. 2001
    ..We elucidated the function of one of these factors, Pax6, in the RPCs of the intact developing eye by conditional gene targeting...
  14. ncbi Hedgehog signalling in the mouse requires intraflagellar transport proteins
    Danwei Huangfu
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, New York 10021, USA
    Nature 426:83-7. 2003
    ..Our data show that IFT machinery has an essential and vertebrate-specific role in Hedgehog signal transduction...
  15. ncbi Altered neural cell fates and medulloblastoma in mouse patched mutants
    L V Goodrich
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5427, USA
    Science 277:1109-13. 1997
    ..Mice heterozygous for the ptc mutation were larger than normal, and a subset of them developed hindlimb defects or cerebellar medulloblastomas, abnormalities also seen in BCNS patients...
  16. ncbi The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
    ..Finally, our data provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation...
  17. pmc Relative roles of the different Pax6 domains for pancreatic alpha cell development
    Petra Dames
    Ludwig Maximilians Universitat, Klinikum Grosshadern, Medizinische Klinik, Munchen, Germany
    BMC Dev Biol 10:39. 2010
    The transcription factor Pax6 functions in the specification and maintenance of the differentiated cell lineages in the endocrine pancreas...
  18. ncbi Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6
    M Schwarz
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Development 127:4325-34. 2000
    We have studied the molecular basis of the Pax2 and Pax6 function in the establishment of visual system territories...
  19. pmc The Tlx gene regulates the timing of neurogenesis in the cortex
    Kristine Roy
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 24:8333-45. 2004
    ..These studies indicate that tlx is an essential intrinsic regulator in the decision to proliferate or differentiate in the developing forebrain...
  20. ncbi Chx10 repression of Mitf is required for the maintenance of mammalian neuroretinal identity
    D Jonathan Horsford
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 132:177-87. 2005
    ..We demonstrate that the repression of Mitf by FGF is Chx10 dependent, indicating that FGF, Chx10 and Mitf are components of a pathway that determines and maintains the identity of the NR...
  21. ncbi Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis
    Ben Martynoga
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Dev Biol 283:113-27. 2005
    ....
  22. ncbi Ftm is a novel basal body protein of cilia involved in Shh signalling
    Jeanette Vierkotten
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Development 134:2569-77. 2007
    ..Furthermore, the absence of Ftm in arthropods underlines the divergence between vertebrate and Drosophila Hh pathways...
  23. pmc A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb
    Monika S Brill
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    J Neurosci 28:6439-52. 2008
    ..Strikingly, Dlx2 requires interaction with Pax6, because Pax6 deletion blocks Dlx2-mediated PGN specification...
  24. pmc Regulation of gene expression by Pax6 in ocular cells: a case of tissue-preferred expression of crystallins in lens
    Ales Cvekl
    The Department of Ophthalmology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Dev Biol 48:829-44. 2004
    ..of crystallin genes by employing synergism between developmentally regulated DNA-binding transcription factors: Pax6, c-Maf, MafA/L-Maf, MafB, NRL, Sox2, Sox1, RARbeta/RXRbeta, RORalpha, Prox1, Six3, gammaFBP-B and HSF2...
  25. ncbi Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    M P Matise
    Developmental Genetics Program and Howard Hughes Medical Institute, and Department of Cell Biology and Physiology and Neuroscience, NYU Medical Center, New York, NY 10016, USA
    Development 125:2759-70. 1998
    ....
  26. ncbi A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    A T Dudley
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 9:2795-807. 1995
    ..Consequently, homozygous mutant animals exhibit renal dysplasia and anophthalmia at birth. Overall, these findings identify BMP-7 as an essential signaling molecule during mammalian kidney and eye development...
  27. ncbi Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    Q Ding
    Program in Developmental Biology and Division of Endocrinology, Research Institute, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Development 125:2533-43. 1998
    ..Our results imply that Gli2 is required to mediate high level but not low level Shh activity and show that the development of motor neurons can occur in the absence of floor plate induction...
  28. ncbi Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other
    Robert F Hevner
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
    J Comp Neurol 447:8-17. 2002
    ..of transcription factor genes expressed specifically in the cortex (Tbr1), the dorsal thalamus (Gbx2), or both (Pax6)...
  29. doi The tumor suppressor Pml regulates cell fate in the developing neocortex
    Tarik Regad
    Medicial Research Council Toxicology Unit, University of Leicester, Box 138 Lancaster Road, Leicester LE1 7JL, UK
    Nat Neurosci 12:132-40. 2009
    ..Together, these findings reveal an unexpected role of Pml in controlling the function of NPCs in the CNS...
  30. pmc Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation
    Shuying He
    Department of Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Epigenetics Chromatin 3:21. 2010
    ..including specific DNA-binding factors (for example, heat shock transcription factor 4 (Hsf4) and paired box gene 6 (Pax6)), chromatin structural proteins (for example, high-mobility group A1 (HMGA1)) and/or acetylated core ..
  31. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
    In humans, haploinsufficiency of either SOX2 or PAX6 is associated with microphthalmia, anophthalmia or aniridia...
  32. pmc Pax6 expression is sufficient to induce a neurogenic fate in glial progenitors of the neonatal subventricular zone
    Eun Sook Jang
    Integrated CMBS and Pathology Graduate Programs, Columbia University, New York, New York, United States of America
    PLoS ONE 6:e20894. 2011
    ..or stabilized in this mixed population is not clear, although previous studies indicate the importance of two transcription factors, Pax6 in neurons and Olig2 in glia, and suggest there may be reciprocal repression between these genes.
  33. pmc 3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes
    Yury Kiselev
    Research Group of Pharmacology, Department of Pharmacy, University of Tromsø, Tromsø, Norway
    PLoS ONE 7:e31915. 2012
    b>Pax6 and Pax6(5a) are two isoforms of the evolutionary conserved Pax6 gene often co-expressed in specific stochiometric relationship in the brain and the eye during development...
  34. ncbi DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site
    T Czerny
    Research Institute of Molecular Pathology, Vienna, Austria
    Genes Dev 7:2048-61. 1993
    ....
  35. ncbi The human PAX6 gene is mutated in two patients with aniridia
    T Jordan
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Nat Genet 1:328-32. 1992
    ..Mutations in Pax-6 have been described previously in Small eye, the proposed mouse model for aniridia. We present new phenotypic evidence for the validity of this mouse model...
  36. ncbi Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
    ..establishing different progenitor cell populations in the ventral neural tube that are defined by the expression of Pax6 and Nkx2.2...
  37. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
    ..Neither Olig gene is required for astrocytes. These findings, together with fate mapping analysis of Olig-expressing cells, indicate that oligodendrocytes are derived from Olig-specified progenitors that give rise also to neurons...
  38. ncbi The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo
    J Martin Collinson
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK
    Dev Biol 255:303-12. 2003
    The roles of Pax6 were investigated in the murine eye and the olfactory epithelium by analysing gene expression and distribution of Pax6(-/-) cells in Pax6(+/+) <--> Pax6(-/-) chimeras. It was found that between embryonic days E10...
  39. ncbi The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation
    Junfeng Wang
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Dev Biol 266:178-89. 2004
    ..This role of Pax4 appears to be accomplished via its genetic interaction with another homeobox gene, Nkx2.2...
  40. ncbi Proper patterning of the optic fissure requires the sequential activity of BMP7 and SHH
    Julian Morcillo
    Departamento de Neurobiologia del Desarrollo, Instituto Cajal, CSIC, Dr Arce 37, Madrid 28002, Spain
    Development 133:3179-90. 2006
    ..Collectively, these data indicate that BMP7 is required for retinal fissure formation and that its activity is needed, before SHH signalling, for the generation of PAX2-positive cells at the optic disc...
  41. ncbi Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes and Nutrition, University Hospital, University of Geneva Medical School, 1211 Geneva 14, Switzerland
    J Biol Chem 282:35024-34. 2007
    ..We conclude that Pax-6 and c-Maf interact with G1 to activate basal expression of the glucagon gene...
  42. doi Chronic wound state exacerbated by oxidative stress in Pax6+/- aniridia-related keratopathy
    J Ou
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    J Pathol 215:421-30. 2008
    Heterozygosity for the transcription factor PAX6 causes eye disease in humans, characterized by corneal opacity. The molecular aetiology of such disease was investigated using a Pax6+/- mouse model...
  43. pmc Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4
    Salvatore Cortellino
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Dev Biol 325:225-37. 2009
    ..We conclude that complex A and complex B factors play similar but distinct roles in ciliogenesis and Shh/Gli3 signaling...
  44. doi Cytoskeletal and cell adhesion defects in wounded and Pax6+/- corneal epithelia
    Jingxing Ou
    School of Medical Sciences, University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom
    Invest Ophthalmol Vis Sci 51:1415-23. 2010
    b>PAX6 heterozygosity (PAX6(+/-)) causes aniridia and aniridia-related keratopathy (ARK) in humans, but the pathway from gene dosage deficiency to clinical disease has not been fully characterized...
  45. pmc Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function
    Yvan Gosmain
    Diabetes Unit, Division of Endocrinology, Diabetes and Nutrition, University Hospital, University Medical Center, University of Geneva, 1211 Geneva 4, Switzerland
    J Biol Chem 285:33381-93. 2010
    The paired box homeodomain Pax6 is crucial for endocrine cell development and function and plays an essential role in glucose homeostasis. Indeed, mutations of Pax6 are associated with diabetic phenotype...
  46. doi Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex
    Lilla M Farkas
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, D 01307 Dresden, Germany
    Neuron 60:40-55. 2008
    ..Our data imply that Insm1 is involved in the generation and expansion of basal progenitors, a hallmark of neocortex evolution...
  47. pmc Intermediate neuronal progenitors (basal progenitors) produce pyramidal-projection neurons for all layers of cerebral cortex
    Tom Kowalczyk
    Departments of Neurological Surgery and Pathology, University of Washington and Center for Neuroscience, Seattle Children s Hospital Research Institute, Seattle, WA 98101, USA
    Cereb Cortex 19:2439-50. 2009
    ..Our findings support the hypothesis that regulated amplification of INPs may be an important factor controlling the balance of neurogenesis among different cortical layers...
  48. ncbi Cortical upper layer neurons derive from the subventricular zone as indicated by Svet1 gene expression
    V Tarabykin
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    Development 128:1983-93. 2001
    ..Interestingly, in the Pax6/small eye mutant, Svet1 activity was abolished in the SVZ and in the upper part of the cortical plate while the ..
  49. ncbi Requirement for Pax6 in corneal morphogenesis: a role in adhesion
    Janine Davis
    Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 2730, USA
    J Cell Sci 116:2157-67. 2003
    The Pax6 transcription factor functions early during embryogenesis to control key steps in brain, pancreas, olfactory and ocular system development. A requirement for Pax6 in proper formation of lens, iris and retina is well documented...
  50. ncbi Foxa2 is required for the differentiation of pancreatic alpha-cells
    Catherine S Lee
    Department of Genetics and Penn Diabetes Center, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB 560 Philadelphia, PA 19104, USA
    Dev Biol 278:484-95. 2005
    ..By marker gene analysis, we show that the expression of the alpha-cell transcription factors Arx, Pax6, and Brn4 does not require Foxa2 in the transcriptional hierarchy governing alpha-cell differentiation.
  51. pmc Vax genes ventralize the embryonic eye
    Stina H Mui
    Molecular Neurobiology Laboratory, The Salk Institute La Jolla, California 92037, USA
    Genes Dev 19:1249-59. 2005
    ..that this transformation results from the loss of ventralizing activity in the developing eye field, and that ventralization is mediated, at least in part, via Vax repression of the Pax6 gene, a potent inducer of retinal development.
  52. ncbi Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip
    Andrew J Fink
    Department of Pathology Neuropathology, University of Washington, Seattle, Washington 98104, USA
    J Neurosci 26:3066-76. 2006
    ..The rhombic lip-derived cells express transcription factors Pax6, Tbr2, and Tbr1 sequentially as they enter the NTZ...
  53. doi Neurotrophin receptor-mediated death of misspecified neurons generated from embryonic stem cells lacking Pax6
    Vassiliki Nikoletopoulou
    Biozentrum, University of Basel, 4056 Basel, Switzerland
    Cell Stem Cell 1:529-40. 2007
    b>Pax6-positive radial glial (RG) cells are the progenitors of most glutamatergic neurons in the cortex, a lineage that can be recapitulated in vitro using embryonic stem (ES) cells...
  54. ncbi Wnt signalling required for expansion of neural crest and CNS progenitors
    M Ikeya
    Centre for Molecular and Developmental Biology, Faculty of Science, Kyoto University, Japan
    Nature 389:966-70. 1997
    ..Given the widespread expression of different Wnt genes in discrete areas of the mammalian neural tube, this may represent a general model for the action of Wnt signalling in the developing CNS...
  55. pmc Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 8:59. 2008
    The transcription factor Pax6 is expressed by many cell types in the developing eye. Eyes do not form in homozygous loss-of-function mouse mutants (Pax6Sey/Sey) and are abnormally small in Pax6Sey/+ mutants...
  56. ncbi Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region
    C C Ton
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Cell 67:1059-74. 1991
    ..The concordance between expression and pathology, map location, structure, and predicted function argues that the cDNA corresponds to the AN gene...
  57. doi Distinct requirements for Ascl1 in subpopulations of midbrain GABAergic neurons
    Paula Peltopuro
    Institute of Biotechnology, P O Box 56, Viikinkaari 9, FIN00014 University of Helsinki, Helsinki, Finland
    Dev Biol 343:63-70. 2010
    ..Also, our results have implications on understanding the origins of the various midbrain GABAergic neuron groups in the embryonic neuroepithelium...
  58. pmc BMP4 is essential for lens induction in the mouse embryo
    Y Furuta
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175 USA
    Genes Dev 12:3764-75. 1998
    ..BMP4 appears to regulate expression of a putative downstream gene, Msx2, in the optic vesicle. No change in Pax6 expression is seen in Bmp4(tm1) mutant eyes, and Bmp4 expression appears unaffected in the eyes of homozygous Pax6(..
  59. pmc A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    C Fode
    Institut de G en etique et de Biologie Mol eculaire et Cellulaire, Centre National de la Recherche Scient ifique Institut National de la Sant e et de la Recherche M edicale, Communaut e Urbaine de Strasbourg, France
    Genes Dev 14:67-80. 2000
    ....
  60. pmc Pax6 is essential for lens fiber cell differentiation
    Ohad Shaham
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Development 136:2567-78. 2009
    ..Although the transcription factors Pax6 and Sox2 have been shown to be essential for lens induction, their later roles during lens fiber differentiation ..
  61. doi A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning
    Madelen Lek
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    Development 137:4051-60. 2010
    ..Conversely, Pax6 has an opposing function to antagonize Shh signaling, which provides intrinsic resistance to Shh responses and is ..
  62. pmc The orchestration of mammalian tissue morphogenesis through a series of coherent feed-forward loops
    Qing Xie
    Department of Genetics, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 286:43259-71. 2011
    ..The ocular lens is a classical model system to study tissue morphogenesis. Pax6 is essential for both lens placode formation and subsequent stages of lens morphogenesis, whereas c-Maf controls ..
  63. pmc BARHL2 differentially regulates the development of retinal amacrine and ganglion neurons
    Qian Ding
    University of Rochester Eye Institute, University of Rochester, Rochester, New York 14642, USA
    J Neurosci 29:3992-4003. 2009
    ..Thus, BARHL2 appears to have numerous roles in retinal development, including regulating neuronal subtype specification, differentiation, and survival...
  64. ncbi Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development
    F D Porter
    Heritable Disorders Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Development 124:2935-44. 1997
    ..Thus Lhx2 is necessary for normal development of the eye, cerebral cortex, and efficient definitive erythropoiesis...
  65. ncbi A role for Pax6 in the normal development of dorsal thalamus and its cortical connections
    T Pratt
    Department of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 127:5167-78. 2000
    The transcription factor Pax6 is widely expressed throughout the developing nervous system, including most alar regions of the newly formed murine diencephalon. Later in embryogenesis its diencephalic expression becomes more restricted...
  66. ncbi Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas
    L St-Onge
    Max Planck Institut fur biophysikalische Chemie, Gottingen, Germany
    Nature 387:406-9. 1997
    ..Here we show that the paired-box gene Pax6 is expressed during the early stages of pancreatic development and in mature endocrine cells...
  67. ncbi Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system
    Q R Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Neuron 25:317-29. 2000
    ..Gain- and loss-of-function analyses in transgenic mice demonstrate that Shh is both necessary and sufficient for Olg gene expression in vivo...
  68. ncbi Pax6 regulates the identity of embryonic diencephalic neurons
    G S Mastick
    Department of Biology, University of Nevada, Reno, Nevada 89557, USA
    Mol Cell Neurosci 17:190-207. 2001
    The transcription factor Pax6 is expressed in discrete domains in the developing brain, generally limited to progenitor populations...
  69. ncbi Generation of GABAergic and dopaminergic interneurons from endogenous embryonic olfactory bulb precursor cells
    Eva Vergaño-Vera
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas CSIC, Spain
    Development 133:4367-79. 2006
    ..5-13.5 mouse OB, whereas the telencephalic pallial domain marker Pax6 is abundant. We found GABAergic and dopaminergic neurons originating from dividing precursor cells in E13...
  70. pmc Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, USA
    Dev Biol 314:443-56. 2008
    During pancreatic development insulin(+) cells co-express the transcription factors MafB and Pax6, and transition from a MafA(-) to MafA(+) state...
  71. doi Hedgehog signaling is involved in development of the neocortex
    Munekazu Komada
    Departmant of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Development 135:2717-27. 2008
    ..Reduced Shh immunoreactivity in mutant dorsal telencephalons supports the above phenotypes. Our data indicate that Shh signaling plays an important role in development of the neocortex...
  72. ncbi Mouse small eye results from mutations in a paired-like homeobox-containing gene
    R E Hill
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Nature 354:522-5. 1991
    Small eye (Sey) in mouse is a semidominant mutation which in the homozygous condition results in the complete lack of eyes and nasal primordia...
  73. ncbi Olfactory bulb development is altered in small-eye (Sey) mice
    T L Dellovade
    Laboratory of Neurobiology and Behavior, Rockefeller University, New York, New York 10021, USA
    J Comp Neurol 402:402-18. 1998
    Small-eye (Sey) is a spontaneous, semidominant murine mutation that results from a point mutation in the Pax-6 gene. Both the eyes and the olfactory system fail to develop in homozygotes and these animals die neonatally...
  74. ncbi Development of the mammillothalamic tract in normal and Pax-6 mutant mice
    F Valverde
    Laboratorio de Neuroanatomia Comparada, Instituto Santiago Ramón y Cajal CSIC, 28002 Madrid, Spain
    J Comp Neurol 419:485-504. 2000
    ..The results of this study suggest that there is a correlation of these cells with a particular type of Golgi impregnated neuron...
  75. ncbi Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas
    M Sander
    Hormone Research Institute, University of California San Francisco, San Francisco, CA 94143 0534, USA
    Development 127:5533-40. 2000
    ..Together, these experiments reveal two independently controlled pathways for beta-cell differentiation, and place Nkx6.1 downstream of Nkx2.2 in the major pathway of beta-cell differentiation...
  76. pmc Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain
    Hikmet F Nural
    Biochemistry Graduate Program, and Biology Department, University of Nevada, Reno, Nevada 89557, USA
    J Comp Neurol 479:399-409. 2004
    ..To start a genetic analysis of pioneer axon guidance, we have identified the transcription factor Pax6 as critical for tract formation...
  77. ncbi Developmental and cellular factors underlying corneal epithelial dysgenesis in the Pax6+/- mouse model of aniridia
    Thaya Ramaesh
    Division of Reproductive and Developmental Sciences, Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Exp Eye Res 81:224-35. 2005
    Heterozygosity for a PAX6 deficiency (PAX6+/-) results in low levels of the PAX6 transcription factor and causes aniridia...
  78. ncbi Neural stem/progenitor cells express 20 tenascin C isoforms that are differentially regulated by Pax6
    Alexander von Holst
    Department of Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, D 44780 Bochum, Germany
    J Biol Chem 282:9172-81. 2007
    ..b>Pax6-deficient small eye (sey) mouse mutants show an altered Tnc expression pattern...
  79. pmc miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex
    Davide De Pietri Tonelli
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Development 135:3911-21. 2008
    ..5. Our results support the emerging concept that progenitors are less dependent on miRNAs than their differentiated progeny, and raise interesting perspectives as to the expansion of somatic stem cells...
  80. doi A novel transient glutamatergic population migrating from the pallial-subpallial boundary contributes to neocortical development
    Anne Teissier
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 7592, Institut Jacques Monod, Universite Paris Diderot, 75205 Paris Cedex 13, France
    J Neurosci 30:10563-74. 2010
    ....
  81. ncbi Roles of Pax-genes in developing and adult brain as suggested by expression patterns
    A Stoykova
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    J Neurosci 14:1395-412. 1994
    ....
  82. ncbi Forebrain patterning defects in Small eye mutant mice
    A Stoykova
    Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 122:3453-65. 1996
    b>Pax6 is a member of the Pax gene family of transcriptional regulators that exhibits a restricted spatiotemporal expression in the developing central nervous system, eye and nose...
  83. pmc Loss of the Sall3 gene leads to palate deficiency, abnormalities in cranial nerves, and perinatal lethality
    M Parrish
    Department of Neurobiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Mol Cell Biol 24:7102-12. 2004
    ..These studies indicate that Sall3 is required for the development of nerves that are derived from the hindbrain and for the formation of adjacent branchial arch derivatives...
  84. ncbi Molecular genetics of the Pax gene family
    R E Hill
    MRC Human Genetics Unit, Western General Hospital, Scotland, UK
    Curr Opin Cell Biol 4:967-72. 1992
    ..The mouse mutants will act as model systems for these human disorders and, in addition, will provide insights into the processes of vertebrate development...
  85. ncbi Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes
    A S Fernandez
    CNRS URA 1414, Equipe Régionalisation nerveuse, Ecole Normale Superieure, 46, rue d Ulm 75230 PARIS Cedex 05 France
    Development 125:2099-111. 1998
    ..Homologies between forebrain subdivisions are proposed based on the conservation and divergence of these gene expression patterns...
  86. ncbi Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain
    M Davenne
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, College de France, Strasbourg
    Neuron 22:677-91. 1999
    ....
  87. ncbi Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors
    Guillermo Estivill-Torrus
    Department of Biomedical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 129:455-66. 2002
    ..The molecular mechanisms regulating these processes are poorly understood. The transcription factor Pax6 is highly expressed in the cortical proliferative zone and there are morphological defects in the Pax6(Sey/Sey) (..
  88. ncbi The transcription factor Bhlhb4 is required for rod bipolar cell maturation
    Debra E Bramblett
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 43:779-93. 2004
    ..Other retinal cell populations including photoreceptors were unaltered. The timing of RB cell depletion in the Bhlhb4(-/-) mouse suggests that Bhlhb4 is essential for RB cell maturation...
  89. ncbi Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1
    Juhee Jeong
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 132:143-54. 2005
    ..Furthermore, this feedback mechanism is crucial in generating a neural tube that contains appropriate numbers of all ventral and intermediate neuronal cell types...
  90. ncbi Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors
    Aimin Liu
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Mailstop 8322, Box 6511, Aurora, CO 80045, USA
    Development 132:3103-11. 2005
    ..In summary, our results indicate that IFT function is crucial in the control of both the positive and negative transcriptional activities of Gli proteins, and essential for Hh ligand-induced signaling cascade...
  91. ncbi The SDF-1/CXCR4 pathway and the development of the cerebellar system
    Tim O Vilz
    Anatomisches Institut, Anatomie und Zellbiologie, Rheinische Friedrich Wilhelms Universitat, Bonn, Germany
    Eur J Neurosci 22:1831-9. 2005
    ..Moreover, they fail to express plexin D1, suggesting that SDF-1/CXCR4 signalling may also impinge on axon guidance critical to the orderly formation of granule cell mossy fibre afferents...
  92. pmc COUP-TFI coordinates cortical patterning, neurogenesis, and laminar fate and modulates MAPK/ERK, AKT, and beta-catenin signaling
    Andrea Faedo
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94158, USA
    Cereb Cortex 18:2117-31. 2008
    ..We suggest that COUP-TFI controls these processes by repressing Mapk/Erk, Akt, and beta-catenin signaling...
  93. ncbi Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse
    B L Hogan
    J Embryol Exp Morphol 97:95-110. 1986
    Small eyes (Sey) is a semidominant, homozygous lethal mutation in the mouse (Roberts, 1967). It is allelic with SeyH, a radiation-induced homozygous prenatal lethal which has been mapped on chromosome 2...
  94. ncbi Multiple functions for Pax6 in mouse eye and nasal development
    J C Quinn
    Department of Obstetrics and Gynecology, University of Edinburgh, UK
    Genes Dev 10:435-46. 1996
    ..Mutations in the Pax6 gene are responsible for the Sey phenotype...
  95. ncbi Pax 6: mastering eye morphogenesis and eye evolution
    W J Gehring
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Trends Genet 15:371-7. 1999
    b>Pax 6 genes from various animal phyla are capable of inducing ectopic eye development, indicating that Pax 6 is a master control gene for eye morphogenesis...
  96. pmc neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, F 67404 Illkirch, France
    Proc Natl Acad Sci U S A 97:1607-11. 2000
    ..Recent genetic studies have identified a network of transcription factors, including Pdx1, Isl1, Pax4, Pax6, NeuroD, Nkx2...
  97. ncbi Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1
    A Pierani
    Howard Hughes Medical Institute, Department of Biochemistry and, Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Neuron 29:367-84. 2001
    ..Thus, a single progenitor homeodomain transcription factor coordinates many of the differentiated properties of one class of interneurons generated in the ventral spinal cord...
  98. ncbi Glial cells generate neurons: the role of the transcription factor Pax6
    Nico Heins
    Max Planck Institute of Neurobiology, Am Klopferspitz 18a, 82152, Planegg Martinsreid, Munich, Germany
    Nat Neurosci 5:308-15. 2002
    ..Here we investigated the role of the transcription factor Pax6 expressed in cortical radial glia...
  99. pmc Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype
    Guy Goudreau
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 99:8719-24. 2002
    b>Pax6 is a key regulator of eye development in vertebrates and invertebrates, and heterozygous loss-of-function mutations of the mouse Pax6 gene result in the Small eye phenotype, in which a small lens is a constant feature...
  100. ncbi Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1
    Thomas Pratt
    Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 22:8523-31. 2002
    ..b>Pax6 is expressed in the dorsal thalamus, but not in the medial part of the ventral telencephalon, and the ..
  101. pmc A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
    Mark Wijgerde
    Department of Molecular and Cellular Biology, The Biolabs, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 16:2849-64. 2002
    ..Thus, Hh signaling is essential for organizing ventral cell pattern, possibly through the control of differential cell affinities...

Research Grants11

  1. Analysis of transcription in lens using tiled microarrays (ChIP on chip)
    Ales Cvekl; Fiscal Year: 2007
    ..will (1) Determine the profiles of binding sites of 5 key transcription factors regulating lens lineage formation, Pax6 and Sox2, and differentiation (c-Maf, Proxl and pRb) with nearly 100 genes/loci encoding proteins essential for ..
  2. Development of Sensory maps in the Mammalian neocortex
    Yasushi Nakagawa; Fiscal Year: 2010
    ..abstract_text> ..
  3. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  4. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010
    ..In addition, the proposed studies will, in the long-term, allow the development of novel therapeutic approaches for treatment of patients with dry eye syndromes. ..
  5. Longitudinal axon guidance by long range cues in the embryonic brain
    GRANT STEPHEN MASTICK; Fiscal Year: 2011
    ....
  6. PIONEER AXON GUIDANCE IN THE EMBRYONIC FOREBRAIN
    GRANT MASTICK; Fiscal Year: 2004
    ..we discovered that the tpoc axons make severe guidance errors in embryos mutant for the transcription factor Pax6. This mutant provides an opportunity to discover how early patterning genes, such as Pax6, might provide positional ..
  7. BHLH FACTOR IN DIABETES & PANCREAS DEVELOPMENT
    DEBRA BRAMBLETT; Fiscal Year: 2003
    ..The BETA4 knockout will be a mouse model system for the study of aspects of pancreas development and possibly pancreatic disease. ..
  8. INVESTIGATING THE ROLE OF CDO IN BRAIN DEVELOPMENT
    Ami Okada; Fiscal Year: 2004
    ..These experiments should also contribute to the overall understanding of the signals that are important in the assembly of the nervous system. ..
  9. Regulation of Laminar Fate in Cerebral Cortex
    Robert Hevner; Fiscal Year: 2006
    ..If molecular fates are aEered in heterochronic or Rein mutant cortex, this would suggest that certain aspects of laminar fate can be regulated post-mitotically. ..
  10. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  11. Regulation of parietal bone differentiation
    Venkatesh Govindarajan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..